DT-Web: DB00213

Identification

Name

Pantoprazole

Accession Number

DB00213 (APRD00073)

Type

small molecule

Description

Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

383.37

Groups

approved

Monoisotopic Weight

383.075133083

Pharmacology

Indication

Short-term (up to 16 weeks) treatment of erosive esophagitis.

Mechanism of action

Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H⁺,K⁺ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

Absorption

Pantoprazole is well absorbed. It undergoes little first-pass metabolism resulting in an absolute bioavailability of approximately 77%.

Protein binding

98%

Biotransformation

Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity.

Route of elimination

After administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, normal metabolizer subjects, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion.

Toxicity

Single intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of toxicity included hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. There is limited experience regarding cases of human overdosage, and treatment should be symptomatic and supportive.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	This gastric pH modifier decreases the levels/effects of atazanavir
Cefditoren	Proton pump inhibitors such as pantoprazole may decrease the serum concentration of cefditoren. If possible, avoid use of cefditoren with proton pump inhibitors (PPIs). Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of PPIs can not be avoided.
Clopidogrel	Pantoprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent pantoprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with pantoprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Dabigatran etexilate	Proton pump inhibitors may decrease the bioavailability of dabigatran by 28% and increase inter-patient pharmacokinetic variability, especially in females. However, dose adjustment is not required.
Dabrafenib	Proton pump inhibitors may alter the solubility of dabrafenib and reduce its bioavailability.
Dasatinib	Pantoprazole may decrease the serum level of dasatinib.
Enoxacin	Pantoprazole may decrease the absorption of enoxacin.
Indinavir	Omeprazole decreases the absorption of indinavir
Itraconazole	The proton pump inhibitor, pantoprazole, may decrease the absorption of itraconazole.
Ketoconazole	The proton pump inhibitor, pantoprazole, may decrease the absorption of ketoconazole.
Rilpivirine	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Topotecan	The BCRP/ABCG2 inhibitor, Pantaprazole, may increase the bioavailability and serum concentration of oral Topotecan. Monitor for change in the therapeutic and adverse effects of Topotecan if Pantaprazole is initiated, discontinued or dose changed.

Food Interactions

Take without regard to meals.

Potassium-transporting ATPase alpha chain 1
Name	Potassium-transporting ATPase alpha chain 1
Gene Name	ATP4A
Pharmacological action	yes
Actions	inhibitor
References	Moreira Dias L: Pantoprazole: a proton pump inhibitor. Clin Drug Investig. 2009;29 Suppl 2:3-12. - Pubmed Cheer SM, Prakash A, Faulds D, Lamb HM: Pantoprazole: an update of its pharmacological properties and therapeutic use in the management of acid-related disorders. Drugs. 2003;63(1):101-33. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3059

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4708
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6516
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.448
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4786

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Pauli-Magnus C, Rekersbrink S, Klotz U, Fromm MF: Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):551-7. - Pubmed
DTHybrid score	0.4646
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Breedveld P, Zelcer N, Pluim D, Sonmezer O, Tibben MM, Beijnen JH, Schinkel AH, van Tellingen O, Borst P, Schellens JH: Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 2004 Aug 15;64(16):5804-11. - Pubmed Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y: Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009 Jan;67(1):44-9. Epub 2008 Nov 17. - Pubmed Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. - Pubmed
DTHybrid score	0.3125
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH, Schellens JH: Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors. Drug Metab Dispos. 2009 Apr;37(4):917-23. Epub 2009 Jan 12. - Pubmed
DTHybrid score	0.2499

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.3039
4924	Cytochrome P450 2C8	CYP2C8	0.2633
4118	Cytochrome P450 3A5	CYP3A5	0.2126
6030	Cytochrome P450 2B6	CYP2B6	0.159
6024	Cytochrome P450 1A1	CYP1A1	0.1566
6107	Cytochrome P450 3A7	CYP3A7	0.1423
6013	Cytochrome P450 2E1	CYP2E1	0.1347
587	Serum albumin	ALB	0.1137
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1071
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1007
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0926
20	Prostaglandin G/H synthase 1	PTGS1	0.0895
5718	Cytochrome P450 2A6	CYP2A6	0.0869
862	Multidrug resistance-associated protein 1	ABCC1	0.0832
6106	Cytochrome P450 2C18	CYP2C18	0.075
1898	Cytochrome P450 1B1	CYP1B1	0.0714
1729	Solute carrier family 22 member 6	SLC22A6	0.07
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0628
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0607
6145	Solute carrier family 22 member 1	SLC22A1	0.0555
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0544
492	Histamine H1 receptor	HRH1	0.0524
6142	Solute carrier family 22 member 8	SLC22A8	0.0492
776	Bile salt export pump	ABCB11	0.0478
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0478
290	Prostaglandin G/H synthase 2	PTGS2	0.047
824	Sodium-dependent serotonin transporter	SLC6A4	0.0465
3811	Cytochrome P450 19A1	CYP19A1	0.0455
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0436
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0433
6144	Solute carrier family 22 member 2	SLC22A2	0.0427
2164	Multidrug resistance-associated protein 4	ABCC4	0.0402
136	Estrogen receptor	ESR1	0.0398
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0397
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0395
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.039
731	HIV-1 protease	HIV-1 protease	0.0385
556	Alpha-1A adrenergic receptor	ADRA1A	0.0382
468	Cytochrome P450 4A11	CYP4A11	0.0381
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0362
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0361
831	D(2) dopamine receptor	DRD2	0.035
817	DNA topoisomerase 2-alpha	TOP2A	0.034
6143	Solute carrier family 22 member 7	SLC22A7	0.0328
118	Organic cation/carnitine transporter 2	SLC22A5	0.0318
871	Glucocorticoid receptor	NR3C1	0.0315
3941	Amine oxidase [flavin-containing] A	MAOA	0.0305
70	Type-1 angiotensin II receptor	AGTR1	0.0303
318	Alpha-2A adrenergic receptor	ADRA2A	0.0299
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0296
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0296
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0288
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0286
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0285
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0284
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0276
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0269
1024	Solute carrier family 22 member 11	SLC22A11	0.0264
632	Alpha-1B adrenergic receptor	ADRA1B	0.0262
23	D(1A) dopamine receptor	DRD1	0.0262
260	Cytochrome P450 51	ERG11	0.0262
761	Cytochrome P450 51	ERG11	0.0262
3163	Cytochrome P450 51	cyp51	0.0262
36	Insulin receptor	INSR	0.0258
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0258
6148	Multidrug resistance-associated protein 7	ABCC10	0.0256
766	Beta-2 adrenergic receptor	ADRB2	0.0256
844	Epidermal growth factor receptor	EGFR	0.0256
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0251
713	Sodium-dependent dopamine transporter	SLC6A3	0.0243
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.024
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0239
193	Beta-1 adrenergic receptor	ADRB1	0.0239
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0233
6147	Solute carrier family 22 member 3	SLC22A3	0.0233
6141	Sodium/bile acid cotransporter	SLC10A1	0.0229
3923	Cholinesterase	BCHE	0.0228
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0226
6137	Multidrug resistance-associated protein 6	ABCC6	0.0225
504	Mast/stem cell growth factor receptor	KIT	0.0222
617	Muscarinic acetylcholine receptor M2	CHRM2	0.022
1353	DNA topoisomerase 1	TOP1	0.0216
3552	DNA topoisomerase 1	topA	0.0216
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0215
450	Muscarinic acetylcholine receptor M4	CHRM4	0.021
833	Organic cation/carnitine transporter 1	SLC22A4	0.0209
789	Alpha-1D adrenergic receptor	ADRA1D	0.0209
26	Vascular endothelial growth factor receptor 3	FLT4	0.0208
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0206
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0206
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0206
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0206
4604	Liver carboxylesterase 1	CES1	0.0204
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0203
847	Mu-type opioid receptor	OPRM1	0.0203
3939	Amine oxidase [flavin-containing] B	MAOB	0.0203
122	P2Y purinoceptor 12	P2RY12	0.0203
407	Vascular endothelial growth factor receptor 2	KDR	0.02
32	Vascular endothelial growth factor receptor 1	FLT1	0.0199
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0192
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0186
467	Delta-type opioid receptor	OPRD1	0.0184
477	DNA topoisomerase 4 subunit A	parC	0.0181
886	DNA topoisomerase 4 subunit A	parC	0.0181
6226	DNA topoisomerase 4 subunit A	parC	0.0181
404	DNA gyrase subunit A	gyrA	0.0178
6224	DNA gyrase subunit A	gyrA	0.0178
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0177
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0177
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0176
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0175
6182	Cytochrome P450 2J2	CYP2J2	0.0174
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0173
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0171
696	Kappa-type opioid receptor	OPRK1	0.017
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.017
6031	Cytochrome P450 3A43	CYP3A43	0.0168
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0168
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0165
629	Alpha-2B adrenergic receptor	ADRA2B	0.0165
117	Sterol O-acyltransferase 1	SOAT1	0.0164
465	Calmodulin	CALM1	0.0164
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0163
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0163
6220	Aryl hydrocarbon receptor	AHR	0.0163
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0161
6136	Multidrug resistance-associated protein 5	ABCC5	0.016
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
869	Estrogen receptor beta	ESR2	0.0158
29	Tubulin beta-1 chain	TUBB1	0.0158
4120	NADPH--cytochrome P450 reductase	POR	0.0158
638	D(3) dopamine receptor	DRD3	0.0157
373	Transthyretin	TTR	0.0152
33	Cystine/glutamate transporter	SLC7A11	0.0151
146	Androgen receptor	AR	0.015
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.015
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0149
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0146
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0142
756	Sex hormone-binding globulin	SHBG	0.0142
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0142
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0142
2539	Tubulin alpha-1 chain	TUBA4A	0.0139
777	Tumor necrosis factor	TNF	0.0139
1757	Myeloperoxidase	MPO	0.0138
3947	Xanthine dehydrogenase/oxidase	XDH	0.0137
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0135
3587	Gastrotropin	FABP6	0.0135
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0134
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0134
614	Progesterone receptor	PGR	0.0134
124	Histamine H2 receptor	HRH2	0.0133
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0133
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0132
891	Dihydropteroate synthase	folP	0.0132
5359	Dihydropteroate synthase	folP	0.0132
7175	Dihydropteroate synthase	sulI	0.0132
275	Arachidonate 5-lipoxygenase	ALOX5	0.0131
738	Monocarboxylate transporter 1	SLC16A1	0.0131
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0129
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0129
818	50S ribosomal protein L10	rplJ	0.0128
378	Alpha-2C adrenergic receptor	ADRA2C	0.0128
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0127
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0125
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0125
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0125
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0125
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
992	Protein tyrosine kinase 2 beta	PTK2B	0.0121
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0121
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0118
161	Tubulin beta chain	TUBB	0.0117
312	Tubulin beta chain	TUB2	0.0117
758	Thyroid hormone receptor alpha	THRA	0.0117
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0113
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0111
432	D(4) dopamine receptor	DRD4	0.0109
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0108
5880	Thrombopoietin receptor	MPL	0.0106
6167	Organic solute transporter subunit beta	OSTB	0.0106
6166	Organic solute transporter subunit alpha	OSTA	0.0106
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0104
346	Thyroid hormone receptor beta-1	THRB	0.0104
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0104
4773	Deoxycytidine kinase	DCK	0.0104
3810	Catechol O-methyltransferase	COMT	0.0102
6014	Cytochrome P450 2A13	CYP2A13	0.0102
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0101
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.01
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.01
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.01
474	Acetylcholinesterase	ACHE	0.01
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.01
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.01
380	Cytochrome P450 17A1	CYP17A1	0.0098
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0097
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
811	Translocator protein	TSPO	0.0096
49	Endothelin B receptor	EDNRB	0.0096
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0096
716	5-hydroxytryptamine 7 receptor	HTR7	0.0094
68	Cannabinoid receptor 1	CNR1	0.0094
1192	Sulfotransferase 1A1	SULT1A1	0.0094
273	Apoptosis regulator Bcl-2	BCL2	0.0093
16	Adenosine A1 receptor	ADORA1	0.0093
183	Vascular endothelial growth factor A	VEGFA	0.0092
952	Dipeptidyl peptidase 4	DPP4	0.0092
1656	CYP2B protein	CYP2B	0.0092
232	Corticosteroid-binding globulin	SERPINA6	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
592	Carbonic anhydrase 4	CA4	0.009
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.009
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.009
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.009
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.009
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.009
904	Glutathione S-transferase P	GSTP1	0.0089
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0089
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0089
1178	Adenosine A2a receptor	ADORA2A	0.0088
365	Dihydrofolate reductase	DHFR	0.0088
2381	Dihydrofolate reductase	DFR1	0.0088
2833	Dihydrofolate reductase	Not Available	0.0088
2931	Dihydrofolate reductase	folA	0.0088
3544	Dihydrofolate reductase	folA	0.0088
3682	Dihydrofolate reductase	folA	0.0088
6642	Dihydrofolate reductase	folA	0.0088
6756	Dihydrofolate reductase	dfrA	0.0088
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0087
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0086
3856	Fibroblast growth factor receptor 3	FGFR3	0.0086
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0085
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0085
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0085
427	Substance-P receptor	TACR1	0.0084
594	Thyroxine-binding globulin	SERPINA7	0.0083
4122	Histone deacetylase 2	HDAC2	0.0083
24	Thymidylate synthase	TMP1	0.0082
359	Thymidylate synthase	TYMS	0.0082
2626	Thymidylate synthase	thyA	0.0082
2729	Thymidylate synthase	thyA	0.0082
5352	Thymidylate synthase	THYA	0.0082
6102	Arylamine N-acetyltransferase 2	NAT2	0.0081
295	Carbonic anhydrase 1	CA1	0.008
6085	Fatty acid-binding protein, intestinal	FABP2	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
563	Thyroid peroxidase	TPO	0.0078
5787	Angiopoietin-1 receptor	TEK	0.0078
6146	High affinity copper uptake protein 1	SLC31A1	0.0077
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0077
165	FL cytokine receptor	FLT3	0.0077
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0077
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0076
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0076
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0075
1010	Cytochrome P450 51A1	CYP51A1	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
1852	Microtubule-associated protein 2	MAP2	0.0074
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0074
823	Fibroblast growth factor receptor 2	FGFR2	0.0073
908	Glutathione S-transferase theta-1	GSTT1	0.0073
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0073
6020	Aldehyde oxidase	AOX1	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0072
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0072
163	D(1B) dopamine receptor	DRD5	0.0072
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0072
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0072
1618	High affinity nerve growth factor receptor	NTRK1	0.0071
239	Coagulation factor X	F10	0.0071
284	DNA-directed RNA polymerase beta chain	rpoB	0.0071
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0071
768	FK506-binding protein 1A	FKBP1A	0.007
2449	Tubulin alpha-3 chain	TUBA1A	0.007
3809	Estrogen-related receptor gamma	ESRRG	0.0069
1760	Aminopeptidase N	ANPEP	0.0069
6843	Aminopeptidase N	pepN	0.0069
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0069
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0069
6044	Serum paraoxonase/lactonase 3	PON3	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0068
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0068
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0067
357	Carbonic anhydrase 2	CA2	0.0067
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0067
921	Glutamate receptor 2	GRIA2	0.0066
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0065
94	5-hydroxytryptamine 4 receptor	HTR4	0.0065
737	Mineralocorticoid receptor	NR3C2	0.0065
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0064
1650	Heme carrier protein 1	SLC46A1	0.0064
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0063
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
6149	Solute carrier family 22 member 10	SLC22A10	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0063
133	Dihydropterate synthase	sulI	0.0063
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
528	5-hydroxytryptamine 1E receptor	HTR1E	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0058
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0058
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0057
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0057
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0056
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0056
469	Annexin A1	ANXA1	0.0056
936	Ephrin type-A receptor 2	EPHA2	0.0056
1517	Beta-3 adrenergic receptor	ADRB3	0.0056
6163	Copper-transporting ATPase 2	ATP7B	0.0055
6165	Copper-transporting ATPase 1	ATP7A	0.0055
482	Glycine receptor subunit alpha-1	GLRA1	0.0054
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0054
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0053
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0053
5923	Microtubule-associated protein tau	MAPT	0.0053
5924	Microtubule-associated protein 4	MAP4	0.0053
896	Glutathione S-transferase Mu 1	GSTM1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6138	Multidrug resistance protein 3	ABCB4	0.0053
814	Ryanodine receptor 1	RYR1	0.0053
6043	Putative G-protein coupled receptor 44	GPR44	0.0053
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0052
4192	DNA topoisomerase 2-beta	TOP2B	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0052
712	Tubulin alpha chain	TUB1	0.0052
6126	Carbonic anhydrase 7	CA7	0.0052
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0051
6432	Transporter	snf	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0051
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0051
1629	Transcription factor AP-1	JUN	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
780	Retinoic acid receptor RXR-gamma	RXRG	0.0051
1630	Integrin beta-2	ITGB2	0.005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.005
4103	Proteasome subunit beta type 2	PSMB2	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.005
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.005
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0049
199	Monocarboxylate transporter 8	SLC16A2	0.0048
1275	Estrogen sulfotransferase	SULT1E1	0.0048
54	Prothrombin	F2	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0048
1525	Heparin-binding growth factor 2	FGF2	0.0048
856	Vitamin D3 receptor	VDR	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
293	Gamma-glutamyl hydrolase	GGH	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
88	Retinoic acid receptor RXR-beta	RXRB	0.0046
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0046
173	Toll-like receptor 7	TLR7	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0045
319	Opioid receptor, sigma 1	OPRS1	0.0045
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0043
518	Peroxidase/catalase T	katG	0.0043
760	Fibroblast growth factor 1	FGF1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
4217	Telomerase reverse transcriptase	TERT	0.0042
4203	Histamine N-methyltransferase	HNMT	0.0041
1648	Elastin	ELN	0.0041
6168	Solute carrier family 22 member 16	SLC22A16	0.0041
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.004
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
6174	50S ribosomal protein L32	rpmF	0.004
153	Dopamine beta-hydroxylase	DBH	0.004
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.004
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0039
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0039
6824	Tyrosine-protein kinase Lyn	LYN	0.0039
1541	Metalloproteinase	mmp20	0.0039
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0039
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0039
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0039
3957	Adenosine deaminase	ADA	0.0038
572	Integrin alpha-L	ITGAL	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0038
7	Nitric oxide synthase, inducible	NOS2	0.0038
85	Growth hormone receptor	GHR	0.0038
1864	RET proto-oncogene	RET	0.0038
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0037
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0037
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0037
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0037
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
705	Glutamate receptor 1	GRIA1	0.0037
634	Squalene monooxygenase	SQLE	0.0037
7196	Squalene monooxygenase	ERG1	0.0037
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0037
2599	Tyrosine-protein kinase HCK	HCK	0.0036
4311	tRNA	TRDMT1	0.0036
4325	tRNA	trmD	0.0036
4328	tRNA	trmD	0.0036
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0036
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0036
3639	Thymidine phosphorylase	deoA	0.0036
3936	Thymidine phosphorylase	TYMP	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0035
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0035
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0035
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0034
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0034
976	Platelet glycoprotein IX	GP9	0.0034
5798	Mitogen-activated protein kinase 11	MAPK11	0.0034
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0033
558	Solute carrier family 12 member 1	SLC12A1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
2320	Thymidine kinase, cytosolic	TK1	0.0033
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0033
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0033
84	Nuclear receptor 0B1	NR0B1	0.0033
5626	Nucleoside diphosphate kinase B	NME2	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0033
6151	Monocarboxylate transporter 10	SLC16A10	0.0033
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0032
581	Cytochrome P450 2R1	CYP2R1	0.0032
267	Plasminogen activator inhibitor 1	SERPINE1	0.0032
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
751	Potassium channel subfamily K member 6	KCNK6	0.0032
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
484	Tyrosine-protein kinase ABL2	ABL2	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4226	Uridine phosphorylase 2	UPP2	0.0031
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6228	Nuclear receptor coactivator 1	NCOA1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
702	UMP-CMP kinase	CMPK1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
1196	Complement decay-accelerating factor	CD55	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0029
6221	Steroid hormone receptor ERR1	ESRRA	0.0029
172	Potassium channel subfamily K member 1	KCNK1	0.0029
4225	Uridine phosphorylase 1	UPP1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
5818	Folate receptor alpha	FOLR1	0.0028
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0028
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
517	Alcohol dehydrogenase 1C	ADH1C	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
2216	Fibroblast growth factor receptor 4	FGFR4	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
164	Histamine H4 receptor	HRH4	0.0027
5294	Nucleoside diphosphate kinase A	NME1	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
413	Amidophosphoribosyltransferase	PPAT	0.0026
2515	Amidophosphoribosyltransferase	purF	0.0026
3714	Amidophosphoribosyltransferase	purF	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
489	Monocarboxylate transporter 2	SLC16A7	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0025
6859	Protein S100-A4	S100A4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6837	Serine/threonine-protein kinase 17B	STK17B	0.0025
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0025
3830	Calreticulin	CALR	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
444	Alcohol dehydrogenase 1B	ADH1B	0.0025
1374	Natriuretic peptides B	NPPB	0.0025
1827	Gap junction alpha-1 protein	GJA1	0.0025
1908	Vascular cell adhesion protein 1	VCAM1	0.0025
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
251	Alcohol dehydrogenase 1A	ADH1A	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0023
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0023
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0023
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0023
174	Sigma 1-type opioid receptor	SIGMAR1	0.0023
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0023
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0023
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
820	Glycine receptor subunit alpha-2	GLRA2	0.0023
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0022
5934	Cytochrome P450 26A1	CYP26A1	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
291	Nitric-oxide synthase, endothelial	NOS3	0.0022
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0022
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
162	Retinoic acid receptor gamma-1	RARG	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0021
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1992	Vitamin D-binding protein	GC	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3937	Fatty-acid amide hydrolase	FAAH	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
1058	Cell division protein kinase 5	CDK5	0.002
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0019
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0019
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0018
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0018
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0018
1253	Interferon gamma	IFNG	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0018
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0018
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0018
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0018
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
1039	Histone deacetylase 9	HDAC9	0.0018
2021	Thrombomodulin	THBD	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0017
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0017
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
2391	Ferrochelatase	hemH	0.0017
6502	Ferrochelatase	DKFZp686P18130	0.0017
1591	Ferrochelatase, mitochondrial	FECH	0.0017
6218	Pannexin-1	PANX1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
1243	Cathepsin D	CTSD	0.0016
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0016
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0016
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0016
268	Adenosine A2b receptor	ADORA2B	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0015
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0015
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
6501	Fatty acid-binding protein, liver	FABP1	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
76	Nitric-oxide synthase, brain	NOS1	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
6500	Phospholipase A2	PLA2G1B	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0011
3221	Cytochrome c4	cc4	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2207	Rhodopsin	RHO	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
1025	Aquaporin-1	AQP1	0.0008
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0008
1268	Neuropeptide S receptor	NPSR1	0.0008
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0008
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
2298	Cytochrome P450-cam	camC	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0007
6072	Potassium channel subfamily K member 3	KCNK3	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1507	Cytochrome c	CYCS	0.0005
798	Osteocalcin	BGLAP	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00213 - Pantoprazole

Targets

Enzymes

Transporters

Predictions