DT-Web: DB08912

Identification

Name

Dabrafenib

Accession Number

DB08912

Type

small molecule

Description

Dabrafenib mesylate is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. FDA approved on May 29, 2013.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

519.562

Groups

approved

Monoisotopic Weight

519.101050904

Pharmacology

Indication

Dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test.

Mechanism of action

Dabrafenib is an inhibitor of some mutated forms of BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM, respectively, and other kinases such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth.

Absorption

After oral administration, median time to achieve peak plasma concentration (Tmax) is 2 hours. Mean absolute bioavailability of oral dabrafenib is 95%.

Protein binding

99.7% bound to human plasma protein.

Biotransformation

Dabrafenib is hepatically metabolized. The biotransformation process is primarily mediated by CYP2C8 and CYP3A4 to form hydroxy-debrafenib. This metabolite is further oxidized via CYP3A4 to form carboxy-dabrafenib and subsequently excreted in bile and urine. Carboxy-dabrafenib can also undergo decarboxylation to form desmethyl-dabrafenib, which may be reabsorbed from the gut. Desmethyl-dabrafenib is further metabolized by CYP3A4 to oxidative metabolites.

Route of elimination

71% of the dose is excreted in feces. 23% of the dose is excreted in the urine as metabolites only.

Toxicity

Most common adverse reactions (>=20%) for dabrafenib are hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Carbamazepine	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Clarithromycin	Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Gemfibrozil	Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Ketoconazole	Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Midazolam	Dabrafenib decreased the maximum concentration (Cmax) and area under the curve (AUC) of midazolam (a substrate of CYP3A4) by 61% and 74%, respectively.
Nefazodone	Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Pantoprazole	Proton pump inhibitors may alter the solubility of dabrafenib and reduce its bioavailability.
Phenobarbital	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Phenytoin	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Ranitidine	H2-receptor antagonists may alter the solubility of dabrafenib and reduce its bioavailability.
Rifampin	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.

Food Interactions

When taken with a fatty meal, Cmax and AUC decreased. Tmax is also prolonged compared to the fasted condition.

B-Raf proto-oncogene serine/threonine-protein kinase
Name	B-Raf proto-oncogene serine/threonine-protein kinase
Gene Name	BRAF
Pharmacological action	yes
Actions	inhibitor
References	FDA label - Gibney GT, Zager JS: Clinical development of dabrafenib in BRAF mutant melanoma and other malignancies. Expert Opin Drug Metab Toxicol. 2013 Jul;9(7):893-9. doi: 10.1517/17425255.2013.794220. Epub 2013 Apr 29. - Pubmed
DTHybrid score	0.9902
RAF proto-oncogene serine/threonine-protein kinase
Name	RAF proto-oncogene serine/threonine-protein kinase
Gene Name	RAF1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.1847
Serine/threonine-protein kinase SIK1
Name	Serine/threonine-protein kinase SIK1
Gene Name	Not Available
Pharmacological action	unknown
Actions	inhibitor
References	FDA label -
DTHybrid score	Not Available
Serine/threonine-protein kinase Nek11
Name	Serine/threonine-protein kinase Nek11
Gene Name	Not Available
Pharmacological action	unknown
Actions	inhibitor
References	FDA label -
DTHybrid score	Not Available
LIM domain kinase 1
Name	LIM domain kinase 1
Gene Name	Not Available
Pharmacological action	unknown
Actions	inhibitor
References	FDA label -
DTHybrid score	Not Available

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	FDA label -
DTHybrid score	0.558
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	FDA label -
DTHybrid score	0.3453

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	FDA label - Mittapalli RK, Vaidhyanathan S, Dudek AZ, Elmquist WF: Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. doi: 10.1124/jpet.112.201475. Epub 2012 Dec 17. - Pubmed
DTHybrid score	0.4889
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate,inhibitor
References	FDA label - Mittapalli RK, Vaidhyanathan S, Dudek AZ, Elmquist WF: Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. doi: 10.1124/jpet.112.201475. Epub 2012 Dec 17. - Pubmed
DTHybrid score	0.3459
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	FDA label -
DTHybrid score	0.381
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	inhibitor
References	FDA label -
DTHybrid score	0.2871
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	FDA label -
DTHybrid score	0.393
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	FDA label -
DTHybrid score	0.3115

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.2702
6016	Cytochrome P450 2C19	CYP2C19	0.2165
4119	Cytochrome P450 2D6	CYP2D6	0.2072
4118	Cytochrome P450 3A5	CYP3A5	0.1969
4200	Cytochrome P450 1A2	CYP1A2	0.1891
587	Serum albumin	ALB	0.1599
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1558
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1522
6030	Cytochrome P450 2B6	CYP2B6	0.1335
6107	Cytochrome P450 3A7	CYP3A7	0.1294
1024	Solute carrier family 22 member 11	SLC22A11	0.1287
862	Multidrug resistance-associated protein 1	ABCC1	0.1178
6143	Solute carrier family 22 member 7	SLC22A7	0.1017
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0996
2164	Multidrug resistance-associated protein 4	ABCC4	0.097
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0902
20	Prostaglandin G/H synthase 1	PTGS1	0.0894
6024	Cytochrome P450 1A1	CYP1A1	0.0887
6013	Cytochrome P450 2E1	CYP2E1	0.0796
26	Vascular endothelial growth factor receptor 3	FLT4	0.0714
776	Bile salt export pump	ABCB11	0.0693
32	Vascular endothelial growth factor receptor 1	FLT1	0.0691
6145	Solute carrier family 22 member 1	SLC22A1	0.0681
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0675
504	Mast/stem cell growth factor receptor	KIT	0.0657
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0654
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0633
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.063
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.062
290	Prostaglandin G/H synthase 2	PTGS2	0.0616
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0614
407	Vascular endothelial growth factor receptor 2	KDR	0.0595
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0581
118	Organic cation/carnitine transporter 2	SLC22A5	0.0552
5718	Cytochrome P450 2A6	CYP2A6	0.0548
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0544
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0536
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0535
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0526
6144	Solute carrier family 22 member 2	SLC22A2	0.0491
6141	Sodium/bile acid cotransporter	SLC10A1	0.0488
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0474
5798	Mitogen-activated protein kinase 11	MAPK11	0.0454
70	Type-1 angiotensin II receptor	AGTR1	0.0454
1898	Cytochrome P450 1B1	CYP1B1	0.0441
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0423
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0423
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0401
6148	Multidrug resistance-associated protein 7	ABCC10	0.0397
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0393
5787	Angiopoietin-1 receptor	TEK	0.0381
3587	Gastrotropin	FABP6	0.0379
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0374
3811	Cytochrome P450 19A1	CYP19A1	0.0374
6106	Cytochrome P450 2C18	CYP2C18	0.0373
136	Estrogen receptor	ESR1	0.0359
492	Histamine H1 receptor	HRH1	0.0357
165	FL cytokine receptor	FLT3	0.0346
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0341
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.034
738	Monocarboxylate transporter 1	SLC16A1	0.0339
936	Ephrin type-A receptor 2	EPHA2	0.0335
871	Glucocorticoid receptor	NR3C1	0.033
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0328
823	Fibroblast growth factor receptor 2	FGFR2	0.0313
833	Organic cation/carnitine transporter 1	SLC22A4	0.031
6136	Multidrug resistance-associated protein 5	ABCC5	0.0309
1618	High affinity nerve growth factor receptor	NTRK1	0.0308
6147	Solute carrier family 22 member 3	SLC22A3	0.0296
29	Tubulin beta-1 chain	TUBB1	0.0295
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0289
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0282
373	Transthyretin	TTR	0.0273
4604	Liver carboxylesterase 1	CES1	0.0271
758	Thyroid hormone receptor alpha	THRA	0.0267
731	HIV-1 protease	HIV-1 protease	0.0264
6167	Organic solute transporter subunit beta	OSTB	0.0254
6166	Organic solute transporter subunit alpha	OSTA	0.0254
594	Thyroxine-binding globulin	SERPINA7	0.0245
824	Sodium-dependent serotonin transporter	SLC6A4	0.0244
844	Epidermal growth factor receptor	EGFR	0.0239
346	Thyroid hormone receptor beta-1	THRB	0.0238
817	DNA topoisomerase 2-alpha	TOP2A	0.0238
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0237
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0236
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0232
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0229
338	DNA polymerase	UL30	0.0228
379	DNA polymerase	UL54	0.0228
697	DNA polymerase	ORF28	0.0228
2482	DNA polymerase	43	0.0228
4104	DNA polymerase	BALF5	0.0228
556	Alpha-1A adrenergic receptor	ADRA1A	0.0222
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0219
1353	DNA topoisomerase 1	TOP1	0.0216
3552	DNA topoisomerase 1	topA	0.0216
6137	Multidrug resistance-associated protein 6	ABCC6	0.0215
633	Penicillin-binding proteins 1A/1B	pbpA	0.0215
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0207
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0198
2016	Dipeptidase 1	DPEP1	0.0197
2539	Tubulin alpha-1 chain	TUBA4A	0.0195
140	30S ribosomal protein S9	rpsI	0.0195
6719	30S ribosomal protein S9	rpsI	0.0195
6725	30S ribosomal protein S9	rpsI	0.0195
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0194
831	D(2) dopamine receptor	DRD2	0.0193
404	DNA gyrase subunit A	gyrA	0.0193
6224	DNA gyrase subunit A	gyrA	0.0193
645	Penicillin-binding protein 1A	mrcA	0.0192
5805	Penicillin-binding protein 1A	ponA	0.0192
6185	Penicillin-binding protein 1A	mrcA	0.0192
6799	Penicillin-binding protein 1A	pbpA	0.0192
33	Cystine/glutamate transporter	SLC7A11	0.0191
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0185
847	Mu-type opioid receptor	OPRM1	0.0184
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0184
22	30S ribosomal protein S4	rpsD	0.0182
6714	30S ribosomal protein S4	rpsD	0.0182
3947	Xanthine dehydrogenase/oxidase	XDH	0.0178
468	Cytochrome P450 4A11	CYP4A11	0.0177
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0175
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0174
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0173
592	Carbonic anhydrase 4	CA4	0.0173
756	Sex hormone-binding globulin	SHBG	0.0171
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0171
467	Delta-type opioid receptor	OPRD1	0.0171
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0168
275	Arachidonate 5-lipoxygenase	ALOX5	0.0168
295	Carbonic anhydrase 1	CA1	0.0168
6020	Aldehyde oxidase	AOX1	0.0166
6031	Cytochrome P450 3A43	CYP3A43	0.0165
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0164
3923	Cholinesterase	BCHE	0.0163
543	Penicillin-binding protein 1B	mrcB	0.0162
6186	Penicillin-binding protein 1B	ponB	0.0162
6822	Penicillin-binding protein 1b	pbp1b	0.0162
6844	Penicillin-binding protein 1b	pbp1b	0.0162
869	Estrogen receptor beta	ESR2	0.0161
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0159
124	Histamine H2 receptor	HRH2	0.0158
6182	Cytochrome P450 2J2	CYP2J2	0.0158
3941	Amine oxidase [flavin-containing] A	MAOA	0.0157
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0157
952	Dipeptidyl peptidase 4	DPP4	0.0156
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0156
696	Kappa-type opioid receptor	OPRK1	0.0155
357	Carbonic anhydrase 2	CA2	0.0155
146	Androgen receptor	AR	0.0151
887	DNA gyrase subunit B	gyrB	0.015
4150	DNA gyrase subunit B	gyrB	0.015
6225	DNA gyrase subunit B	gyrB	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6149	Solute carrier family 22 member 10	SLC22A10	0.0147
5626	Nucleoside diphosphate kinase B	NME2	0.0147
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
1852	Microtubule-associated protein 2	MAP2	0.0144
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0144
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0142
4120	NADPH--cytochrome P450 reductase	POR	0.0141
273	Apoptosis regulator Bcl-2	BCL2	0.014
199	Monocarboxylate transporter 8	SLC16A2	0.0139
632	Alpha-1B adrenergic receptor	ADRA1B	0.0139
318	Alpha-2A adrenergic receptor	ADRA2A	0.0137
766	Beta-2 adrenergic receptor	ADRB2	0.0135
260	Cytochrome P450 51	ERG11	0.0135
761	Cytochrome P450 51	ERG11	0.0135
3163	Cytochrome P450 51	cyp51	0.0135
24	Thymidylate synthase	TMP1	0.0135
359	Thymidylate synthase	TYMS	0.0135
2626	Thymidylate synthase	thyA	0.0135
2729	Thymidylate synthase	thyA	0.0135
5352	Thymidylate synthase	THYA	0.0135
117	Sterol O-acyltransferase 1	SOAT1	0.0134
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0134
193	Beta-1 adrenergic receptor	ADRB1	0.0133
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0133
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0132
5923	Microtubule-associated protein tau	MAPT	0.0129
5924	Microtubule-associated protein 4	MAP4	0.0129
244	Angiotensin-converting enzyme	ACE	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0126
1757	Myeloperoxidase	MPO	0.0125
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0125
614	Progesterone receptor	PGR	0.0123
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
438	Taste receptor type 1 member 2	TAS1R2	0.0122
4773	Deoxycytidine kinase	DCK	0.0122
3639	Thymidine phosphorylase	deoA	0.0122
3936	Thymidine phosphorylase	TYMP	0.0122
723	Cytosolic phospholipase A2	PLA2G4A	0.012
23	D(1A) dopamine receptor	DRD1	0.012
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.012
5294	Nucleoside diphosphate kinase A	NME1	0.012
3917	Methylenetetrahydrofolate reductase	MTHFR	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
558	Solute carrier family 12 member 1	SLC12A1	0.0119
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0118
477	DNA topoisomerase 4 subunit A	parC	0.0118
886	DNA topoisomerase 4 subunit A	parC	0.0118
6226	DNA topoisomerase 4 subunit A	parC	0.0118
789	Alpha-1D adrenergic receptor	ADRA1D	0.0116
1650	Heme carrier protein 1	SLC46A1	0.0115
6085	Fatty acid-binding protein, intestinal	FABP2	0.0114
5880	Thrombopoietin receptor	MPL	0.0114
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0112
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0112
3686	Acyl-CoA thioesterase I precursor	tesA	0.0111
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.011
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
450	Muscarinic acetylcholine receptor M4	CHRM4	0.011
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0109
6220	Aryl hydrocarbon receptor	AHR	0.0109
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0108
465	Calmodulin	CALM1	0.0107
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0107
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0106
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0105
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0105
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0105
380	Cytochrome P450 17A1	CYP17A1	0.0104
293	Gamma-glutamyl hydrolase	GGH	0.0104
6151	Monocarboxylate transporter 10	SLC16A10	0.0104
2320	Thymidine kinase, cytosolic	TK1	0.0103
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0103
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0102
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0101
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0101
161	Tubulin beta chain	TUBB	0.01
312	Tubulin beta chain	TUB2	0.01
713	Sodium-dependent dopamine transporter	SLC6A3	0.0098
3856	Fibroblast growth factor receptor 3	FGFR3	0.0096
365	Dihydrofolate reductase	DHFR	0.0096
2381	Dihydrofolate reductase	DFR1	0.0096
2833	Dihydrofolate reductase	Not Available	0.0096
2931	Dihydrofolate reductase	folA	0.0096
3544	Dihydrofolate reductase	folA	0.0096
3682	Dihydrofolate reductase	folA	0.0096
6642	Dihydrofolate reductase	folA	0.0096
6756	Dihydrofolate reductase	dfrA	0.0096
122	P2Y purinoceptor 12	P2RY12	0.0095
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0095
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0095
6126	Carbonic anhydrase 7	CA7	0.0094
1192	Sulfotransferase 1A1	SULT1A1	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
3809	Estrogen-related receptor gamma	ESRRG	0.0093
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0091
232	Corticosteroid-binding globulin	SERPINA6	0.0091
5353	Glutamate decarboxylase alpha	gadA	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
818	50S ribosomal protein L10	rplJ	0.0085
3810	Catechol O-methyltransferase	COMT	0.0085
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0084
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
638	D(3) dopamine receptor	DRD3	0.0083
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0082
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0079
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0079
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0079
332	Beta-lactamase	blaZ	0.0079
2478	Beta-lactamase	ampC	0.0079
2613	Beta-lactamase	ampC	0.0079
2635	Beta-lactamase	ampC	0.0079
2700	Beta-lactamase	penP	0.0079
5445	Beta-lactamase	blaB	0.0079
6019	Beta-lactamase	SHV-7	0.0079
6701	Beta-lactamase	cphA	0.0079
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0079
811	Translocator protein	TSPO	0.0078
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0078
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0078
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0077
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0077
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0077
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0076
629	Alpha-2B adrenergic receptor	ADRA2B	0.0076
115	Penicillin-binding protein 2	mrdA	0.0076
6069	Penicillin-binding protein 2	mrdA	0.0076
6118	Penicillin-binding protein 2	penA	0.0076
6187	Penicillin-binding protein 2	pbpA	0.0076
6686	Penicillin-binding protein 2	pbp2	0.0076
6939	Penicillin-binding protein 2	mrdA	0.0076
7163	Penicillin-binding protein 2	pbpA	0.0076
992	Protein tyrosine kinase 2 beta	PTK2B	0.0076
1867	Major prion protein	PRNP	0.0075
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0075
737	Mineralocorticoid receptor	NR3C2	0.0075
183	Vascular endothelial growth factor A	VEGFA	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
3932	Glutathione S-transferase A2	GSTA2	0.0074
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
474	Acetylcholinesterase	ACHE	0.0073
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0073
5818	Folate receptor alpha	FOLR1	0.0072
6043	Putative G-protein coupled receptor 44	GPR44	0.0072
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0072
904	Glutathione S-transferase P	GSTP1	0.0071
68	Cannabinoid receptor 1	CNR1	0.0071
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
6014	Cytochrome P450 2A13	CYP2A13	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
284	DNA-directed RNA polymerase beta chain	rpoB	0.0071
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0071
768	FK506-binding protein 1A	FKBP1A	0.007
6102	Arylamine N-acetyltransferase 2	NAT2	0.007
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.007
4217	Telomerase reverse transcriptase	TERT	0.007
1760	Aminopeptidase N	ANPEP	0.0069
6843	Aminopeptidase N	pepN	0.0069
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0069
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0069
130	Prostacyclin synthase	PTGIS	0.0068
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0068
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0067
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0066
908	Glutathione S-transferase theta-1	GSTT1	0.0066
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0065
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0065
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0065
6033	High affinity interleukin-8 receptor A	CXCR1	0.0065
6207	30S ribosomal protein S14	rpsN	0.0065
6209	30S ribosomal protein S19	rpsS	0.0065
6712	30S ribosomal protein S19	rpsS	0.0065
6726	30S ribosomal protein S19	rpsS	0.0065
378	Alpha-2C adrenergic receptor	ADRA2C	0.0065
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0065
3685	Catabolite gene activator	crp	0.0065
4655	Adenylate cyclase	cyaC	0.0064
4759	Adenylate cyclase	cyaB2	0.0064
777	Tumor necrosis factor	TNF	0.0064
469	Annexin A1	ANXA1	0.0064
3939	Amine oxidase [flavin-containing] B	MAOB	0.0064
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6168	Solute carrier family 22 member 16	SLC22A16	0.0062
4237	50S ribosomal protein L22	rplV	0.0062
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0062
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0061
1405	Thiopurine S-methyltransferase	TPMT	0.0061
65	Matrix metalloproteinase-9	Not Available	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0059
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0058
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0058
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0058
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
3426	Glutamine synthetase	glnA	0.0057
3987	Glutamine synthetase	GLUL	0.0057
6138	Multidrug resistance protein 3	ABCB4	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0056
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0056
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0056
2249	Aspartate aminotransferase	aspC	0.0056
2671	Aspartate aminotransferase	aspC	0.0056
5490	Aspartate aminotransferase	Not Available	0.0056
6146	High affinity copper uptake protein 1	SLC31A1	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0056
239	Coagulation factor X	F10	0.0056
4760	Mll3241 protein	mll3241	0.0055
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0055
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0055
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0055
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0055
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0055
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0054
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0054
716	5-hydroxytryptamine 7 receptor	HTR7	0.0054
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0053
2391	Ferrochelatase	hemH	0.0053
6502	Ferrochelatase	DKFZp686P18130	0.0053
1591	Ferrochelatase, mitochondrial	FECH	0.0053
1050	Bile salt sulfotransferase	SULT2A1	0.0053
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0053
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0052
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
1198	Serum paraoxonase/arylesterase 1	PON1	0.005
6171	Solute carrier family 28 member 3	SLC28A3	0.005
6223	Penicillin-binding protein 1C	pbpC	0.005
527	Prostacyclin receptor	PTGIR	0.005
5300	Antigen peptide transporter 1	TAP1	0.005
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.005
1541	Metalloproteinase	mmp20	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0049
1141	Sialidase-1	NEU1	0.0049
672	Prostaglandin F2-alpha receptor	PTGFR	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
4122	Histone deacetylase 2	HDAC2	0.0048
814	Ryanodine receptor 1	RYR1	0.0048
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0048
4192	DNA topoisomerase 2-beta	TOP2B	0.0048
1525	Heparin-binding growth factor 2	FGF2	0.0048
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0047
1010	Cytochrome P450 51A1	CYP51A1	0.0047
718	Folate receptor gamma	FOLR3	0.0047
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0047
299	Folate receptor beta	FOLR2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
6824	Tyrosine-protein kinase Lyn	LYN	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
867	Penicillin-binding protein 3	pbpC	0.0046
6119	Penicillin-binding protein 3	pbp3	0.0046
7154	Penicillin-binding protein 3	pbp3	0.0046
7157	Penicillin-binding protein 3	LMHCC_2184	0.0046
7162	Penicillin-binding protein 3	pbpB	0.0046
7172	Penicillin-binding protein 3	pbp3	0.0046
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0046
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0046
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0046
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0046
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0046
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0046
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0046
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0046
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0046
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0046
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0046
6559	Cytochrome c oxidase subunit 2	ctaC	0.0046
6669	Cytochrome c oxidase subunit 2	ctaC	0.0046
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0046
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0046
6558	Cytochrome c oxidase subunit 1	ctaD	0.0046
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0046
88	Retinoic acid receptor RXR-beta	RXRB	0.0046
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0045
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0045
1654	Interleukin-1 beta	IL1B	0.0045
6163	Copper-transporting ATPase 2	ATP7B	0.0045
6165	Copper-transporting ATPase 1	ATP7A	0.0045
432	D(4) dopamine receptor	DRD4	0.0045
896	Glutathione S-transferase Mu 1	GSTM1	0.0045
1630	Integrin beta-2	ITGB2	0.0045
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0045
563	Thyroid peroxidase	TPO	0.0044
6131	Carbonic anhydrase 14	CA14	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
489	Monocarboxylate transporter 2	SLC16A7	0.0044
2599	Tyrosine-protein kinase HCK	HCK	0.0044
760	Fibroblast growth factor 1	FGF1	0.0044
1629	Transcription factor AP-1	JUN	0.0044
106	Cannabinoid receptor 2	CNR2	0.0044
856	Vitamin D3 receptor	VDR	0.0043
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0043
891	Dihydropteroate synthase	folP	0.0043
5359	Dihydropteroate synthase	folP	0.0043
7175	Dihydropteroate synthase	sulI	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0042
2540	Choloylglycine hydrolase	cbh	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
53	Solute carrier family 12 member 5	SLC12A5	0.0042
663	Solute carrier family 12 member 4	SLC12A4	0.0042
702	UMP-CMP kinase	CMPK1	0.0042
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0042
427	Substance-P receptor	TACR1	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0041
6122	Carbonic anhydrase 3	CA3	0.0041
751	Potassium channel subfamily K member 6	KCNK6	0.0041
408	Riboflavin kinase	RFK	0.0041
1656	CYP2B protein	CYP2B	0.0041
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0041
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
4203	Histamine N-methyltransferase	HNMT	0.004
2021	Thrombomodulin	THBD	0.004
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.004
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.004
6501	Fatty acid-binding protein, liver	FABP1	0.004
1178	Adenosine A2a receptor	ADORA2A	0.0039
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0039
310	Solute carrier family 12 member 2	SLC12A2	0.0039
5482	Sialidase-2	NEU2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
319	Opioid receptor, sigma 1	OPRS1	0.0039
172	Potassium channel subfamily K member 1	KCNK1	0.0038
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0037
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
494	Caspase-1	CASP1	0.0037
2808	Chloramphenicol acetyltransferase 3	cat3	0.0037
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0037
1507	Cytochrome c	CYCS	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
2216	Fibroblast growth factor receptor 4	FGFR4	0.0037
6044	Serum paraoxonase/lactonase 3	PON3	0.0036
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0036
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0036
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0036
707	72 kDa type IV collagenase	MMP2	0.0036
162	Retinoic acid receptor gamma-1	RARG	0.0036
6218	Pannexin-1	PANX1	0.0036
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0036
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
4116	Dihydropteroate synthetase	Not Available	0.0035
2112	Toll-like receptor 9	TLR9	0.0035
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0035
6837	Serine/threonine-protein kinase 17B	STK17B	0.0035
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0035
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0035
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0034
3007	Carbonic anhydrase 12	CA12	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
4205	Carbonic anhydrase 9	CA9	0.0034
572	Integrin alpha-L	ITGAL	0.0034
2417	Chloramphenicol acetyltransferase	cat	0.0034
3278	Chloramphenicol acetyltransferase	cat	0.0034
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0034
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0033
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0033
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0033
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
3760	Penicillin-binding protein 5 precursor	dacA	0.0033
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
6500	Phospholipase A2	PLA2G1B	0.0033
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0033
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0032
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0032
84	Nuclear receptor 0B1	NR0B1	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
517	Alcohol dehydrogenase 1C	ADH1C	0.0032
1039	Histone deacetylase 9	HDAC9	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
1714	Mitogen-activated protein kinase 3	MAPK3	0.0032
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0031
6174	50S ribosomal protein L32	rpmF	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
2077	Caspase-3	CASP3	0.0031
16	Adenosine A1 receptor	ADORA1	0.0031
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1648	Elastin	ELN	0.0031
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.003
94	5-hydroxytryptamine 4 receptor	HTR4	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.003
819	Penicillin-binding protein 4	dacB	0.003
208	DNA-directed RNA polymerase beta' chain	rpoC	0.003
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.003
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0029
654	Flavin reductase	BLVRB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0029
634	Squalene monooxygenase	SQLE	0.0028
7196	Squalene monooxygenase	ERG1	0.0028
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
571	Melatonin receptor type 1A	MTNR1A	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
362	Melatonin receptor type 1B	MTNR1B	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
7	Nitric oxide synthase, inducible	NOS2	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
1792	Tissue-type plasminogen activator	PLAT	0.0028
267	Plasminogen activator inhibitor 1	SERPINE1	0.0028
921	Glutamate receptor 2	GRIA2	0.0028
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0028
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0027
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0027
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0027
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0027
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2300	Lysozyme	E	0.0027
3633	Lysozyme	R	0.0027
5597	Lysozyme	17	0.0027
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0027
4311	tRNA	TRDMT1	0.0026
4325	tRNA	trmD	0.0026
4328	tRNA	trmD	0.0026
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
780	Retinoic acid receptor RXR-gamma	RXRG	0.0026
4226	Uridine phosphorylase 2	UPP2	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
581	Cytochrome P450 2R1	CYP2R1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
605	Fumarate reductase flavoprotein subunit	frdA	0.0026
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0026
3673	Fumarate reductase flavoprotein subunit	fccA	0.0026
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0026
6549	Fumarate reductase flavoprotein subunit	frdA	0.0026
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
6221	Steroid hormone receptor ERR1	ESRRA	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0025
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
6103	Arylamine N-acetyltransferase 1	NAT1	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0025
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0025
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
4225	Uridine phosphorylase 1	UPP1	0.0024
1275	Estrogen sulfotransferase	SULT1E1	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0024
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6042	Prostaglandin reductase 2	PTGR2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
6228	Nuclear receptor coactivator 1	NCOA1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
518	Peroxidase/catalase T	katG	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0023
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
413	Amidophosphoribosyltransferase	PPAT	0.0022
2515	Amidophosphoribosyltransferase	purF	0.0022
3714	Amidophosphoribosyltransferase	purF	0.0022
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1864	RET proto-oncogene	RET	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0021
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0021
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0021
6432	Transporter	snf	0.002
976	Platelet glycoprotein IX	GP9	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0019
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0019
54	Prothrombin	F2	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
1313	Lactoylglutathione lyase	GLO1	0.0018
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
174	Sigma 1-type opioid receptor	SIGMAR1	0.0018
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0018
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0018
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0017
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
3957	Adenosine deaminase	ADA	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
5682	Ribonuclease pancreatic	RNASE1	0.0016
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
2408	Tyrosine-protein kinase SYK	SYK	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0016
173	Toll-like receptor 7	TLR7	0.0016
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0016
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6755	Poliovirus receptor	PVR	0.0015
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
1992	Vitamin D-binding protein	GC	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
2207	Rhodopsin	RHO	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
291	Nitric-oxide synthase, endothelial	NOS3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
822	Aldose reductase	AKR1B1	0.0014
5934	Cytochrome P450 26A1	CYP26A1	0.0013
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
164	Histamine H4 receptor	HRH4	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3937	Fatty-acid amide hydrolase	FAAH	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
76	Nitric-oxide synthase, brain	NOS1	0.0012
1295	Fatty acid synthase	FASN	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0012
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0012
6859	Protein S100-A4	S100A4	0.0012
2236	Casein kinase II subunit alpha	CSNK2A1	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
268	Adenosine A2b receptor	ADORA2B	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
997	Protein kinase C beta type	PRKCB	0.001
569	Retinal dehydrogenase 2	ALDH1A2	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3221	Cytochrome c4	cc4	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4943	Cytochrome c6	petJ	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4961	Hemophore HasA	hasA	0.0003
4909	CooA protein	cooA	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
5000	HemO	hemO	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4910	Cytoglobin	CYGB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4972	P450cin	cinA	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
4920	Peroxidase/catalase	katG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
4948	Cytochrome c-553	Not Available	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
6021	Adenosine kinase	ADK	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08912 - Dabrafenib

Targets

Enzymes

Transporters

Predictions