DT-Web: DB00683

Identification

Name

Midazolam

Accession Number

DB00683 (APRD00680)

Type

small molecule

Description

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. [PubChem] Midazolam is a schedule IV drug in the United States.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

325.767

Groups

illicit

Monoisotopic Weight

325.078203343

Pharmacology

Indication

The midazolam injection is indicated for preoperative sedation/anziolysis/amnesia. It is also an agent for sedation/anziolysis/amnesia prior to or during diagnostic, therapeutic, or endoscopic procedures. Midazolam can also be given intravenously for induction of general anaesthesia.

Mechanism of action

It is thought that the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the brain. Benzodiazepines increase the activity of GABA, thereby producing a calming effect, relaxing skeletal muscles, and inducing sleep. Benzodiazepines bind to the benzodiazepine site on GABA-A receptors, which potentiates the effects of GABA by increasing the frequency of chloride channel opening.

Absorption

Rapidly absorbed after oral administration. The absolute bioavailability of the midazolam syrup in pediatric patients is about 36%. The absolute bioavailability, if given intramuscularly (IM), is greater than 90%. Cmax, IM = 90 ng/mL; Tmax, IM = 0.5 hours. Following IM administered, Cmax for midazolam and its 1-hydroxy metabolite were approxiately one-half of those achieved after intravenous injection.

Protein binding

97% protein bound.

Biotransformation

Midazolam is primarily metabolized in the liver and gut by human cytochrome P450 IIIA4 (CYP3A4) to its pharmacologic active metabolite, (alpha)-hydroxymidazolam (also known as 1-hydroxy-midazolam), and 4-hydroxymidazolam (makes up 5% or less of the biotransformation products). 1-hydroxy-midazolam is at least as potent as the parent compound and may contributed to the overall activity of midazolam. In vitro studies have demonstrated that the affinities of 1- and 4-hydroxy-midazolam for the benzodiazepine receptor are approximately 20% and 7%, respectively, relative to midazolam. It also undergoes N-glucuronidation via UGT1A4.

Route of elimination

Midazolam is primarily metabolized in the liver and gut by human cytochrome P450 IIIA4 (CYP3A4) to its pharmacologic active metabolite, ?-hydroxymidazolam, followed by glucuronidation of the ?-hydroxyl metabolite which is present in unconjugated and conjugated forms in human plasma. The ?- hydroxymidazolam glucuronide is then excreted in urine. No significant amount of parent drug or metabolites is extractable from urine before beta-glucuronidase and sulfatase deconjugation, indicating that the urinary metabolites are excreted mainly as conjugates. The amount of midazolam excreted unchanged in the urine when given intravenously is less than 0.5%. 45% to 57% of the dose was excreted in the urine as 1-hydroxymethyl midazolam conjugate.

Toxicity

LD₅₀=825 mg/kg (Orally in rats). Signs of overdose include sedation, somnolence, confusion, impaired coordination, diminished reflexes, coma, and deleterious effects on vital signs.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amprenavir	Amprenavir may increase the effect and toxicity of the benzodiazepine, midazolam.
Aprepitant	Aprepitant may increase the effect and toxicity of the benzodiazepine, midazolam.
Atazanavir	Atazanavir may increase the effect and toxicity of the benzodiazepine, midazolam.
Boceprevir	Boceprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Carbamazepine	Carbamazepine may decrease the effect of the benzodiazepine, midazolam.
Cimetidine	Cimetidine may increase the effect of the benzodiazepine, midazolam.
Clarithromycin	The macrolide, clarithromycin, may increase the effect of the benzodiazepine, midazolam.
Clobazam	Clobazam decrease the Cmax and AUC of midazolam by approximately 25% of both and increases the Cmax and AUC of its metabolite. Dose adjustment is not necessary.
Clozapine	Increased risk of toxicity
Crizotinib	Strong CYP3A4 inhibitors may increase levels of crizotinib. Monitor concomitant therapy closely.
Crizotinib	Strong CYP3A4 inhibitors may increase levels of crizotinib. Monitor concomitant therapy closely.
Dabrafenib	Dabrafenib decreased the maximum concentration (Cmax) and area under the curve (AUC) of midazolam (a substrate of CYP3A4) by 61% and 74%, respectively.
Delavirdine	The antiviral agent, delavirdine, may increase the effect and toxicity of the benzodiazepine, midazolam.
Diltiazem	The calcium channel blocker, diltiazem, may increase the effect and toxicity of the benzodiazepine, midazolam.
Docetaxel	Midazolam may increase the serum levels and toxicity of docetaxel.
Efavirenz	The antiviral agent, efavirenz, may increase the effect and toxicity of the benzodiazepine, midazolam.
Erythromycin	The macrolide, erythromycin, may increase the effect of the benzodiazepine, midazolam.
Ethotoin	Ethotoin may increase the metabolism of midazolam via CYP3A4.
Fluconazole	Fluconazole may increase the effect of the benzodiazepine, midazolam.
Fosamprenavir	Fosamprenavir may increase the effect and toxicity of the benzodiazepine, midazolam.
Fosphenytoin	Fosphenytoin may increase the metabolism of midazolam via CYP3A4.
Indinavir	The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, midazolam.
Itraconazole	Itraconazole may increase the effect of the benzodiazepine, midazolam.
Josamycin	The macrolide, josamycin, may increase the effect of the benzodiazepine, midazolam.
Kava	Kava may increase the effect of the benzodiazepine, midazolam.
Ketoconazole	Ketoconazole may increase the effect of the benzodiazepine, midazolam.
Mephenytoin	Mephenytoin may increase the metabolism of midazolam via CYP3A4.
Nelfinavir	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, midazolam.
Omeprazole	Omeprazole may increase the effect of the benzodiazepine, midazolam.
Phenytoin	Phenytoin may increase the metabolism of midazolam via CYP3A4.
Quinupristin	This combination presents an increased risk of toxicity
Rifampin	Rifampin may increase the metabolism of midazolam. Monitor for changes in the therapeutic and adverse effects of midazolam if rifampin is initiated, discontinued or dose changed.
Ritonavir	The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, midazolam.
Saquinavir	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, midazolam.
St. John's Wort	St. John's Wort may decrease the effect of the benzodiazepine, midazolam.
Telaprevir	Telaprevir increases AUC and Cmax of oral midazolam by approximately 9-fold and 3-fold respectively.
Telithromycin	Telithromycin may increase the effect and toxicity of the benzodiazepine, midazolam.
Tipranavir	Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Midazolam. Concomitant therapy is contraindicated.
Triprolidine	The CNS depressants, Triprolidine and Midazolam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Vemurafenib	Vemurafenib decreases the AUC (CYP3A4 substrate) by 39%.
Verapamil	Verapamil may increase the serum concentration of Midazolam by decreasing its metabolism. Avoid concomitant therapy if possible or consider a dose reduction in the initial dose of Midazolam.
Voriconazole	Voriconazole may increase the serum concentration of midazolam by decreasing its metabolism. Monitor for midazolam toxicity if voriconazole is initiated or dose increased.

Food Interactions

Grapefruit juice slows the product's absorption and significantly increases its bioavailability.

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2616
Gamma-aminobutyric-acid receptor subunit alpha-2
Name	Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name	GABRA2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1927
Gamma-aminobutyric-acid receptor subunit alpha-3
Name	Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name	GABRA3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1898
Gamma-aminobutyric-acid receptor subunit alpha-4
Name	Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name	GABRA4
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.8551
Gamma-aminobutyric-acid receptor subunit alpha-5
Name	Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name	GABRA5
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2139
Gamma-aminobutyric-acid receptor subunit beta-1
Name	Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name	GABRB1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0673
Gamma-aminobutyric-acid receptor subunit beta-3
Name	Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name	GABRB3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0721
Gamma-aminobutyric-acid receptor subunit beta-2
Name	Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name	GABRB2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0562
Gamma-aminobutyric-acid receptor subunit alpha-6
Name	Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name	GABRA6
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.8238
Gamma-aminobutyric acid receptor subunit gamma-1
Name	Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name	GABRG1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0553
Gamma-aminobutyric acid receptor subunit gamma-2
Name	Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name	GABRG2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0878
Gamma-aminobutyric acid receptor subunit gamma-3
Name	Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name	GABRG3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.037
Gamma-aminobutyric acid receptor subunit delta
Name	Gamma-aminobutyric acid receptor subunit delta
Gene Name	GABRD
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0439
Gamma-aminobutyric acid receptor subunit epsilon
Name	Gamma-aminobutyric acid receptor subunit epsilon
Gene Name	GABRE
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0421
Gamma-aminobutyric acid receptor subunit pi
Name	Gamma-aminobutyric acid receptor subunit pi
Gene Name	GABRP
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0277
Gamma-aminobutyric-acid receptor subunit rho-1
Name	Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name	GABRR1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0331
Gamma-aminobutyric acid receptor subunit rho-2
Name	Gamma-aminobutyric acid receptor subunit rho-2
Gene Name	GABRR2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0386
Gamma-aminobutyric acid receptor subunit rho-3
Name	Gamma-aminobutyric acid receptor subunit rho-3
Gene Name	GABRR3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0356
Gamma-aminobutyric acid receptor subunit theta
Name	Gamma-aminobutyric acid receptor subunit theta
Gene Name	GABRQ
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.6865

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Foti RS, Rock DA, Wienkers LC, Wahlstrom JL: Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation. Drug Metab Dispos. 2010 Jun;38(6):981-7. Epub 2010 Mar 4. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Pelkonen O, Maenpaa J, Taavitsainen P, Rautio A, Raunio H: Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica. 1998 Dec;28(12):1203-53. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Zhou S, Chan E, Lim LY, Boelsterli UA, Li SC, Wang J, Zhang Q, Huang M, Xu A: Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab. 2004 Oct;5(5):415-42. - Pubmed Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. - Pubmed Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. - Pubmed Obach RS, Reed-Hagen AE: Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. Drug Metab Dispos. 2002 Jul;30(7):831-7. - Pubmed
DTHybrid score	1.0678
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Patki KC, Von Moltke LL, Greenblatt DJ: In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. - Pubmed Wandel C, Bocker R, Bohrer H, Browne A, Rugheimer E, Martin E: Midazolam is metabolized by at least three different cytochrome P450 enzymes. Br J Anaesth. 1994 Nov;73(5):658-61. - Pubmed Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed
DTHybrid score	0.5137
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Gorski JC, Hall SD, Jones DR, VandenBranden M, Wrighton SA: Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol. 1994 Apr 29;47(9):1643-53. - Pubmed Ghosal A, Satoh H, Thomas PE, Bush E, Moore D: Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450. Drug Metab Dispos. 1996 Sep;24(9):940-7. - Pubmed Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed
DTHybrid score	0.4374
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Ekins S, Vandenbranden M, Ring BJ, Gillespie JS, Yang TJ, Gelboin HV, Wrighton SA: Further characterization of the expression in liver and catalytic activity of CYP2B6. J Pharmacol Exp Ther. 1998 Sep;286(3):1253-9. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed
DTHybrid score	0.4456
Cytochrome P450 4B1
Name	Cytochrome P450 4B1
Gene Name	CYP4B1
Actions	substrate
References	Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-4
Name	UDP-glucuronosyltransferase 1-4
Gene Name	UGT1A4
Actions	substrate
References	Klieber S, Hugla S, Ngo R, Arabeyre-Fabre C, Meunier V, Sadoun F, Fedeli O, Rival M, Bourrie M, Guillou F, Maurel P, Fabre G: Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans. Drug Metab Dispos. 2008 May;36(5):851-62. doi: 10.1124/dmd.107.019539. Epub 2008 Feb 6. - Pubmed
DTHybrid score	0.1832
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Tassaneeyakul W, Birkett DJ, Miners JO: Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and non-steroidal anti-inflammatory agents. Xenobiotica. 1998 Mar;28(3):293-301. - Pubmed
DTHybrid score	0.4647

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. Eur J Pharm Sci. 2001 Feb;12(4):505-13. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Takano M, Hasegawa R, Fukuda T, Yumoto R, Nagai J, Murakami T: Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur J Pharmacol. 1998 Oct 9;358(3):289-94. - Pubmed Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score	0.5683
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
DTHybrid score	0.2494

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.4623
4757	Cytochrome P450 2C9	CYP2C9	0.414
811	Translocator protein	TSPO	0.4015
4119	Cytochrome P450 2D6	CYP2D6	0.3501
4200	Cytochrome P450 1A2	CYP1A2	0.3235
4924	Cytochrome P450 2C8	CYP2C8	0.3003
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.2943
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.2941
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.2857
921	Glutamate receptor 2	GRIA2	0.2523
5718	Cytochrome P450 2A6	CYP2A6	0.1691
587	Serum albumin	ALB	0.1647
6106	Cytochrome P450 2C18	CYP2C18	0.1527
6024	Cytochrome P450 1A1	CYP1A1	0.133
6144	Solute carrier family 22 member 2	SLC22A2	0.1219
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0991
20	Prostaglandin G/H synthase 1	PTGS1	0.0973
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0889
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0796
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.078
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0774
6031	Cytochrome P450 3A43	CYP3A43	0.0742
862	Multidrug resistance-associated protein 1	ABCC1	0.0725
6102	Arylamine N-acetyltransferase 2	NAT2	0.0677
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0671
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0666
556	Alpha-1A adrenergic receptor	ADRA1A	0.0665
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0645
831	D(2) dopamine receptor	DRD2	0.0644
492	Histamine H1 receptor	HRH1	0.0631
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0617
3811	Cytochrome P450 19A1	CYP19A1	0.0578
776	Bile salt export pump	ABCB11	0.0573
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0571
482	Glycine receptor subunit alpha-1	GLRA1	0.0551
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0549
1898	Cytochrome P450 1B1	CYP1B1	0.0546
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0546
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0536
118	Organic cation/carnitine transporter 2	SLC22A5	0.0513
824	Sodium-dependent serotonin transporter	SLC6A4	0.0513
6147	Solute carrier family 22 member 3	SLC22A3	0.05
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0467
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0441
1729	Solute carrier family 22 member 6	SLC22A6	0.044
23	D(1A) dopamine receptor	DRD1	0.0437
318	Alpha-2A adrenergic receptor	ADRA2A	0.0426
847	Mu-type opioid receptor	OPRM1	0.042
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0413
833	Organic cation/carnitine transporter 1	SLC22A4	0.0399
6142	Solute carrier family 22 member 8	SLC22A8	0.0375
871	Glucocorticoid receptor	NR3C1	0.0373
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0372
465	Calmodulin	CALM1	0.0365
461	Glycine receptor subunit alpha-3	GLRA3	0.0364
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0362
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0357
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0357
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0351
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.035
136	Estrogen receptor	ESR1	0.0347
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0345
632	Alpha-1B adrenergic receptor	ADRA1B	0.0339
6143	Solute carrier family 22 member 7	SLC22A7	0.0332
260	Cytochrome P450 51	ERG11	0.0327
761	Cytochrome P450 51	ERG11	0.0327
3163	Cytochrome P450 51	cyp51	0.0327
731	HIV-1 protease	HIV-1 protease	0.0324
468	Cytochrome P450 4A11	CYP4A11	0.0318
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0315
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0311
856	Vitamin D3 receptor	VDR	0.031
820	Glycine receptor subunit alpha-2	GLRA2	0.0309
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0309
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0306
766	Beta-2 adrenergic receptor	ADRB2	0.0303
638	D(3) dopamine receptor	DRD3	0.0299
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0296
467	Delta-type opioid receptor	OPRD1	0.0296
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0292
705	Glutamate receptor 1	GRIA1	0.0289
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0289
629	Alpha-2B adrenergic receptor	ADRA2B	0.0288
378	Alpha-2C adrenergic receptor	ADRA2C	0.0279
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0274
3923	Cholinesterase	BCHE	0.0273
193	Beta-1 adrenergic receptor	ADRB1	0.0271
696	Kappa-type opioid receptor	OPRK1	0.0266
3937	Fatty-acid amide hydrolase	FAAH	0.0263
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.026
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0257
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0254
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0254
713	Sodium-dependent dopamine transporter	SLC6A3	0.0251
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0248
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0248
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0244
2164	Multidrug resistance-associated protein 4	ABCC4	0.0243
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0243
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0242
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0238
6148	Multidrug resistance-associated protein 7	ABCC10	0.0237
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0236
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0234
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0231
738	Monocarboxylate transporter 1	SLC16A1	0.0226
290	Prostaglandin G/H synthase 2	PTGS2	0.0218
614	Progesterone receptor	PGR	0.0211
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0207
3947	Xanthine dehydrogenase/oxidase	XDH	0.0207
4604	Liver carboxylesterase 1	CES1	0.0206
817	DNA topoisomerase 2-alpha	TOP2A	0.0205
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0205
789	Alpha-1D adrenergic receptor	ADRA1D	0.0205
124	Histamine H2 receptor	HRH2	0.0203
6182	Cytochrome P450 2J2	CYP2J2	0.0201
2981	Phospholipase A2, membrane associated	PLA2G2A	0.02
432	D(4) dopamine receptor	DRD4	0.02
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0198
756	Sex hormone-binding globulin	SHBG	0.0198
6859	Protein S100-A4	S100A4	0.0192
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0191
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0191
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0191
716	5-hydroxytryptamine 7 receptor	HTR7	0.0189
3426	Glutamine synthetase	glnA	0.0188
3987	Glutamine synthetase	GLUL	0.0188
869	Estrogen receptor beta	ESR2	0.0187
172	Potassium channel subfamily K member 1	KCNK1	0.0186
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0184
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.018
737	Mineralocorticoid receptor	NR3C2	0.0179
3941	Amine oxidase [flavin-containing] A	MAOA	0.0176
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0175
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0171
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0168
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0167
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0165
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0165
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0162
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0161
3939	Amine oxidase [flavin-containing] B	MAOB	0.016
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.016
122	P2Y purinoceptor 12	P2RY12	0.0159
474	Acetylcholinesterase	ACHE	0.0159
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0157
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0157
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0157
232	Corticosteroid-binding globulin	SERPINA6	0.0154
818	50S ribosomal protein L10	rplJ	0.0154
1192	Sulfotransferase 1A1	SULT1A1	0.0154
504	Mast/stem cell growth factor receptor	KIT	0.0152
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0152
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
6141	Sodium/bile acid cotransporter	SLC10A1	0.0144
4120	NADPH--cytochrome P450 reductase	POR	0.0143
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0141
6020	Aldehyde oxidase	AOX1	0.014
29	Tubulin beta-1 chain	TUBB1	0.014
844	Epidermal growth factor receptor	EGFR	0.0139
489	Monocarboxylate transporter 2	SLC16A7	0.0139
6136	Multidrug resistance-associated protein 5	ABCC5	0.0137
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0136
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0135
1010	Cytochrome P450 51A1	CYP51A1	0.0134
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0134
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0134
6137	Multidrug resistance-associated protein 6	ABCC6	0.0134
1024	Solute carrier family 22 member 11	SLC22A11	0.0132
62	Glycine receptor subunit beta	GLRB	0.0132
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.013
6220	Aryl hydrocarbon receptor	AHR	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0125
161	Tubulin beta chain	TUBB	0.0123
312	Tubulin beta chain	TUB2	0.0123
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0122
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0121
146	Androgen receptor	AR	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
777	Tumor necrosis factor	TNF	0.0118
500	Monocarboxylate transporter 4	SLC16A3	0.0118
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
26	Vascular endothelial growth factor receptor 3	FLT4	0.0114
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0114
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0113
174	Sigma 1-type opioid receptor	SIGMAR1	0.0112
477	DNA topoisomerase 4 subunit A	parC	0.0109
886	DNA topoisomerase 4 subunit A	parC	0.0109
6226	DNA topoisomerase 4 subunit A	parC	0.0109
32	Vascular endothelial growth factor receptor 1	FLT1	0.0109
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
407	Vascular endothelial growth factor receptor 2	KDR	0.0107
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0107
1656	CYP2B protein	CYP2B	0.0107
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0107
380	Cytochrome P450 17A1	CYP17A1	0.0106
723	Cytosolic phospholipase A2	PLA2G4A	0.0106
16	Adenosine A1 receptor	ADORA1	0.0106
952	Dipeptidyl peptidase 4	DPP4	0.0105
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0105
4773	Deoxycytidine kinase	DCK	0.0105
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0103
267	Plasminogen activator inhibitor 1	SERPINE1	0.0103
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.01
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.01
3809	Estrogen-related receptor gamma	ESRRG	0.01
94	5-hydroxytryptamine 4 receptor	HTR4	0.01
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0099
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0099
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0097
427	Substance-P receptor	TACR1	0.0096
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0096
4237	50S ribosomal protein L22	rplV	0.0095
6221	Steroid hormone receptor ERR1	ESRRA	0.0095
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0093
6014	Cytochrome P450 2A13	CYP2A13	0.0093
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0093
1178	Adenosine A2a receptor	ADORA2A	0.0092
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0092
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0091
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0091
672	Prostaglandin F2-alpha receptor	PTGFR	0.009
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0089
131	Synaptic vesicular amine transporter	SLC18A2	0.0089
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0089
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0087
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0085
1039	Histone deacetylase 9	HDAC9	0.0084
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0083
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0083
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
592	Carbonic anhydrase 4	CA4	0.0082
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0082
1757	Myeloperoxidase	MPO	0.0082
163	D(1B) dopamine receptor	DRD5	0.0082
319	Opioid receptor, sigma 1	OPRS1	0.0081
6138	Multidrug resistance protein 3	ABCB4	0.0081
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0081
3932	Glutathione S-transferase A2	GSTA2	0.008
1852	Microtubule-associated protein 2	MAP2	0.0079
164	Histamine H4 receptor	HRH4	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
444	Alcohol dehydrogenase 1B	ADH1B	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
2539	Tubulin alpha-1 chain	TUBA4A	0.0076
251	Alcohol dehydrogenase 1A	ADH1A	0.0075
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0075
165	FL cytokine receptor	FLT3	0.0075
153	Dopamine beta-hydroxylase	DBH	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
814	Ryanodine receptor 1	RYR1	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
469	Annexin A1	ANXA1	0.0073
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0072
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0072
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0071
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0071
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.007
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.007
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.007
6432	Transporter	snf	0.007
976	Platelet glycoprotein IX	GP9	0.0068
244	Angiotensin-converting enzyme	ACE	0.0068
1618	High affinity nerve growth factor receptor	NTRK1	0.0068
904	Glutathione S-transferase P	GSTP1	0.0068
4122	Histone deacetylase 2	HDAC2	0.0067
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0066
295	Carbonic anhydrase 1	CA1	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0066
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0065
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0065
84	Nuclear receptor 0B1	NR0B1	0.0065
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0064
239	Coagulation factor X	F10	0.0064
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0064
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0064
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0064
891	Dihydropteroate synthase	folP	0.0063
5359	Dihydropteroate synthase	folP	0.0063
7175	Dihydropteroate synthase	sulI	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0062
1483	Membrane copper amine oxidase	AOC3	0.0062
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0062
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0061
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0061
357	Carbonic anhydrase 2	CA2	0.006
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.006
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0059
517	Alcohol dehydrogenase 1C	ADH1C	0.0059
373	Transthyretin	TTR	0.0059
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0059
70	Type-1 angiotensin II receptor	AGTR1	0.0059
5923	Microtubule-associated protein tau	MAPT	0.0059
5924	Microtubule-associated protein 4	MAP4	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0058
6171	Solute carrier family 28 member 3	SLC28A3	0.0058
1517	Beta-3 adrenergic receptor	ADRB3	0.0058
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0058
284	DNA-directed RNA polymerase beta chain	rpoB	0.0058
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0058
6085	Fatty acid-binding protein, intestinal	FABP2	0.0057
4203	Histamine N-methyltransferase	HNMT	0.0057
823	Fibroblast growth factor receptor 2	FGFR2	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0056
273	Apoptosis regulator Bcl-2	BCL2	0.0056
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0056
908	Glutathione S-transferase theta-1	GSTT1	0.0055
1050	Bile salt sulfotransferase	SULT2A1	0.0054
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0054
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0053
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0053
3810	Catechol O-methyltransferase	COMT	0.0052
694	Matrix protein 2	M	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
5300	Antigen peptide transporter 1	TAP1	0.0051
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0051
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.005
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.005
54	Prothrombin	F2	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
3601	Dihydropteroate synthase 1	folP1	0.0049
3807	Dihydropteroate synthase 1	folP1	0.0049
3808	Dihydropteroate synthase 2	folP2	0.0049
1630	Integrin beta-2	ITGB2	0.0048
6766	O-GlcNAcase BT_4395	BT_4395	0.0048
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
751	Potassium channel subfamily K member 6	KCNK6	0.0046
3913	Glutamic acid decarboxylase	GAD65	0.0046
2230	Catalase	CAT	0.0045
3249	Catalase	katA	0.0045
3625	Catalase	katA	0.0045
4539	Catalase	katA	0.0045
4941	Catalase	katB	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
3611	Cytidine deaminase	cdd	0.0045
3707	Cytidine deaminase	cdd	0.0045
4211	Cytidine deaminase	CDA	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0044
563	Thyroid peroxidase	TPO	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
7	Nitric oxide synthase, inducible	NOS2	0.0043
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
780	Retinoic acid receptor RXR-gamma	RXRG	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0042
1830	5'-nucleotidase	NT5E	0.0042
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
6070	Nischarin	NISCH	0.0041
6167	Organic solute transporter subunit beta	OSTB	0.0041
125	DNA polymerase beta	POLB	0.0041
6166	Organic solute transporter subunit alpha	OSTA	0.0041
1864	RET proto-oncogene	RET	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
365	Dihydrofolate reductase	DHFR	0.0039
2381	Dihydrofolate reductase	DFR1	0.0039
2833	Dihydrofolate reductase	Not Available	0.0039
2931	Dihydrofolate reductase	folA	0.0039
3544	Dihydrofolate reductase	folA	0.0039
3682	Dihydrofolate reductase	folA	0.0039
6642	Dihydrofolate reductase	folA	0.0039
6756	Dihydrofolate reductase	dfrA	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
88	Retinoic acid receptor RXR-beta	RXRB	0.0039
275	Arachidonate 5-lipoxygenase	ALOX5	0.0039
4192	DNA topoisomerase 2-beta	TOP2B	0.0039
6146	High affinity copper uptake protein 1	SLC31A1	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3904	Alanine aminotransferase 2	GPT2	0.0038
735	Alanine aminotransferase 1	GPT	0.0038
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0038
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0038
2472	Voltage-gated potassium channel	kcsA	0.0038
6366	Voltage-gated potassium channel	kcsA	0.0038
896	Glutathione S-transferase Mu 1	GSTM1	0.0037
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0037
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6165	Copper-transporting ATPase 1	ATP7A	0.0037
6163	Copper-transporting ATPase 2	ATP7B	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
6126	Carbonic anhydrase 7	CA7	0.0036
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0036
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0036
1268	Neuropeptide S receptor	NPSR1	0.0036
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0036
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0036
3404	Exotoxin A	eta	0.0036
4311	tRNA	TRDMT1	0.0035
4325	tRNA	trmD	0.0035
4328	tRNA	trmD	0.0035
33	Cystine/glutamate transporter	SLC7A11	0.0035
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0035
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0035
828	Phenylalanine-4-hydroxylase	PAH	0.0035
3109	Phenylalanine-4-hydroxylase	phhA	0.0035
719	Retinoic acid receptor responder protein 1	RARRES1	0.0035
770	Retinoic acid-induced protein 3	GPRC5A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0034
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0034
5787	Angiopoietin-1 receptor	TEK	0.0034
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
1341	Histamine H3 receptor	HRH3	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
6073	Potassium channel subfamily K member 9	KCNK9	0.0033
6072	Potassium channel subfamily K member 3	KCNK3	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
702	UMP-CMP kinase	CMPK1	0.0032
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0032
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0032
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
5934	Cytochrome P450 26A1	CYP26A1	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
65	Matrix metalloproteinase-9	Not Available	0.0031
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
936	Ephrin type-A receptor 2	EPHA2	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0031
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0031
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0031
569	Retinal dehydrogenase 2	ALDH1A2	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1650	Heme carrier protein 1	SLC46A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6149	Solute carrier family 22 member 10	SLC22A10	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
162	Retinoic acid receptor gamma-1	RARG	0.0029
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0029
5126	Arginase	rocF	0.0029
2207	Rhodopsin	RHO	0.0029
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0029
518	Peroxidase/catalase T	katG	0.0029
1629	Transcription factor AP-1	JUN	0.0029
611	Retinal dehydrogenase 1	ALDH1A1	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0028
2298	Cytochrome P450-cam	camC	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0028
2300	Lysozyme	E	0.0028
3633	Lysozyme	R	0.0028
5597	Lysozyme	17	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
6111	DNA polymerase epsilon subunit 4	POLE4	0.0027
6112	DNA polymerase epsilon subunit 3	POLE3	0.0027
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0026
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0026
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0026
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0026
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0026
6110	DNA polymerase epsilon subunit 2	POLE2	0.0026
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0026
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0026
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0026
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0026
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0026
605	Fumarate reductase flavoprotein subunit	frdA	0.0026
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0026
3673	Fumarate reductase flavoprotein subunit	fccA	0.0026
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0026
6549	Fumarate reductase flavoprotein subunit	frdA	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
572	Integrin alpha-L	ITGAL	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0025
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0025
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0025
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0025
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0025
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
183	Vascular endothelial growth factor A	VEGFA	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4221	Vascular endothelial growth factor	VEGF	0.0023
1374	Natriuretic peptides B	NPPB	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0023
1827	Gap junction alpha-1 protein	GJA1	0.0023
5816	Cadherin-5	CDH5	0.0023
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
5626	Nucleoside diphosphate kinase B	NME2	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
291	Nitric-oxide synthase, endothelial	NOS3	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6218	Pannexin-1	PANX1	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
293	Gamma-glutamyl hydrolase	GGH	0.002
603	DNA polymerase alpha catalytic subunit	POLA1	0.002
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.002
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0019
6459	Glycodelin	PAEP	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
3957	Adenosine deaminase	ADA	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
3587	Gastrotropin	FABP6	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0019
5294	Nucleoside diphosphate kinase A	NME1	0.0019
1992	Vitamin D-binding protein	GC	0.0019
5798	Mitogen-activated protein kinase 11	MAPK11	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0018
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
1275	Estrogen sulfotransferase	SULT1E1	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
3924	Phospholipase D1	PLD1	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3221	Cytochrome c4	cc4	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
277	Purine nucleoside phosphorylase	PNP	0.0015
2870	Purine nucleoside phosphorylase	punA	0.0015
2945	Purine nucleoside phosphorylase	punA	0.0015
4659	Purine nucleoside phosphorylase	TM_1596	0.0015
4825	Purine nucleoside phosphorylase	TTHA1435	0.0015
6755	Poliovirus receptor	PVR	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
1541	Metalloproteinase	mmp20	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
85	Growth hormone receptor	GHR	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0012
1295	Fatty acid synthase	FASN	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
2802	Endoglucanase G	celCCG	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
76	Nitric-oxide synthase, brain	NOS1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
997	Protein kinase C beta type	PRKCB	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
798	Osteocalcin	BGLAP	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
369	Coagulation factor VII	F7	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4943	Cytochrome c6	petJ	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4909	CooA protein	cooA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
5000	HemO	hemO	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4935	Cytochrome c-554	cycA1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4972	P450cin	cinA	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4961	Hemophore HasA	hasA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
4952	Catalase/peroxidase	katA	0.0004
3093	Catalase HPII	katE	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
4920	Peroxidase/catalase	katG	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4990	PpcA	ppcA	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
1507	Cytochrome c	CYCS	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00683 - Midazolam

Targets

Enzymes

Transporters

Predictions