DT-Web: DB00863

Identification

Name

Ranitidine

Accession Number

DB00863 (APRD00254)

Type

small molecule

Description

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

314.404

Groups

approved

Monoisotopic Weight

314.14126128

Pharmacology

Indication

Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).

Mechanism of action

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Absorption

Approximately 50% bioavailability orally.

Protein binding

15%

Biotransformation

Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively.

Route of elimination

The principal route of excretion is the urine (active tubular excretion, renal clearance 410mL/min), with approximately 30% of the orally administered dose collected in the urine as unchanged drug in 24 hours.

Toxicity

LD₅₀=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Ranitidine may increase the anticoagulant effect of acenocoumarol. (Conflicting evidence)
Anisindione	Ranitidine may increase the anticoagulant effect of anisindione. (Conflicting evidence)
Atazanavir	Ranitidine may decrease the levels/effects of atazanavir.
Cefditoren	H2-Antagonists such as ranitidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.
Dabrafenib	H2-receptor antagonists may alter the solubility of dabrafenib and reduce its bioavailability.
Dasatinib	Ranitidine may decrease the serum level of dasatinib.
Dicumarol	Ranitidine may increase the anticoagulant effect of dicumarol. (Conflicting evidence)
Itraconazole	The H2-receptor antagonist, ranitidine, may decrease the absorption of itraconazole.
Ketoconazole	The H2-receptor antagonist, ranitidine, may decrease the absorption of ketoconazole.
Procainamide	The histamine H2-receptor antagonist, ranitidine, may increase the effect of procainamide.
Rilpivirine	Histamine-2 receptor antagonists increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Tolazoline	Anticipated loss of efficacy of tolazoline
Vismodegib	Vismodegib serum concentrations may be decreased by histamine 2 receptor antagonists such as ranitidine.
Warfarin	Ranitidine may increase the anticoagulant effect of warfarin. (Conflicting evidence)

Food Interactions

Take without regard to meals.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.
Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.

Histamine H2 receptor
Name	Histamine H2 receptor
Gene Name	HRH2
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Pattichis K, Louca LL: Histamine, histamine H2-receptor antagonists, gastric acid secretion and ulcers: an overview. Drug Metabol Drug Interact. 1995;12(1):1-36. - Pubmed
DTHybrid score	0.5824

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4304
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4031
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5036
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6819
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3485

Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
DTHybrid score	0.2615
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE: Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res. 2000 Dec;17(12):1456-60. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.47
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate
References	Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. - Pubmed
DTHybrid score	0.2287

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.3181
6107	Cytochrome P450 3A7	CYP3A7	0.2177
4924	Cytochrome P450 2C8	CYP2C8	0.2128
6030	Cytochrome P450 2B6	CYP2B6	0.1686
6013	Cytochrome P450 2E1	CYP2E1	0.1426
6144	Solute carrier family 22 member 2	SLC22A2	0.1415
6024	Cytochrome P450 1A1	CYP1A1	0.1317
1729	Solute carrier family 22 member 6	SLC22A6	0.1245
587	Serum albumin	ALB	0.1148
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1089
492	Histamine H1 receptor	HRH1	0.0961
5718	Cytochrome P450 2A6	CYP2A6	0.0877
118	Organic cation/carnitine transporter 2	SLC22A5	0.0852
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0825
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0822
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0799
556	Alpha-1A adrenergic receptor	ADRA1A	0.0772
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.076
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0758
1024	Solute carrier family 22 member 11	SLC22A11	0.0753
6143	Solute carrier family 22 member 7	SLC22A7	0.0748
831	D(2) dopamine receptor	DRD2	0.0731
20	Prostaglandin G/H synthase 1	PTGS1	0.0723
824	Sodium-dependent serotonin transporter	SLC6A4	0.0716
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0698
862	Multidrug resistance-associated protein 1	ABCC1	0.0672
6147	Solute carrier family 22 member 3	SLC22A3	0.0662
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0624
318	Alpha-2A adrenergic receptor	ADRA2A	0.0593
833	Organic cation/carnitine transporter 1	SLC22A4	0.0564
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0549
6106	Cytochrome P450 2C18	CYP2C18	0.0545
766	Beta-2 adrenergic receptor	ADRB2	0.054
3923	Cholinesterase	BCHE	0.0528
23	D(1A) dopamine receptor	DRD1	0.0511
193	Beta-1 adrenergic receptor	ADRB1	0.0504
776	Bile salt export pump	ABCB11	0.0502
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0488
632	Alpha-1B adrenergic receptor	ADRA1B	0.047
3811	Cytochrome P450 19A1	CYP19A1	0.0464
1898	Cytochrome P450 1B1	CYP1B1	0.0449
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0433
290	Prostaglandin G/H synthase 2	PTGS2	0.0431
2164	Multidrug resistance-associated protein 4	ABCC4	0.0425
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0423
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0418
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0411
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0411
590	5-hydroxytryptamine 2C receptor	HTR2C	0.041
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0406
713	Sodium-dependent dopamine transporter	SLC6A3	0.0385
871	Glucocorticoid receptor	NR3C1	0.0375
847	Mu-type opioid receptor	OPRM1	0.037
731	HIV-1 protease	HIV-1 protease	0.0368
629	Alpha-2B adrenergic receptor	ADRA2B	0.0365
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0353
378	Alpha-2C adrenergic receptor	ADRA2C	0.035
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0348
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.033
638	D(3) dopamine receptor	DRD3	0.0329
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0324
136	Estrogen receptor	ESR1	0.0323
3941	Amine oxidase [flavin-containing] A	MAOA	0.0322
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0322
789	Alpha-1D adrenergic receptor	ADRA1D	0.0313
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0305
817	DNA topoisomerase 2-alpha	TOP2A	0.0305
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0305
467	Delta-type opioid receptor	OPRD1	0.0299
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0297
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0289
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0276
696	Kappa-type opioid receptor	OPRK1	0.0274
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0268
260	Cytochrome P450 51	ERG11	0.0267
761	Cytochrome P450 51	ERG11	0.0267
3163	Cytochrome P450 51	cyp51	0.0267
6031	Cytochrome P450 3A43	CYP3A43	0.0264
716	5-hydroxytryptamine 7 receptor	HTR7	0.026
36	Insulin receptor	INSR	0.0258
6148	Multidrug resistance-associated protein 7	ABCC10	0.0257
3939	Amine oxidase [flavin-containing] B	MAOB	0.0257
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0256
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0252
465	Calmodulin	CALM1	0.0252
725	5-hydroxytryptamine 1D receptor	HTR1D	0.025
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0245
432	D(4) dopamine receptor	DRD4	0.0243
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0239
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0236
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0228
474	Acetylcholinesterase	ACHE	0.0227
6182	Cytochrome P450 2J2	CYP2J2	0.0227
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0223
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0223
6141	Sodium/bile acid cotransporter	SLC10A1	0.0221
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0218
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0217
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0211
6136	Multidrug resistance-associated protein 5	ABCC5	0.0207
756	Sex hormone-binding globulin	SHBG	0.0207
3947	Xanthine dehydrogenase/oxidase	XDH	0.0206
477	DNA topoisomerase 4 subunit A	parC	0.0205
886	DNA topoisomerase 4 subunit A	parC	0.0205
6226	DNA topoisomerase 4 subunit A	parC	0.0205
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0203
404	DNA gyrase subunit A	gyrA	0.0202
6224	DNA gyrase subunit A	gyrA	0.0202
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0201
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.02
4604	Liver carboxylesterase 1	CES1	0.0197
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0194
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0187
146	Androgen receptor	AR	0.0187
468	Cytochrome P450 4A11	CYP4A11	0.0186
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0186
338	DNA polymerase	UL30	0.0185
379	DNA polymerase	UL54	0.0185
697	DNA polymerase	ORF28	0.0185
2482	DNA polymerase	43	0.0185
4104	DNA polymerase	BALF5	0.0185
614	Progesterone receptor	PGR	0.0183
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0182
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0175
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0175
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0174
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0173
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0173
738	Monocarboxylate transporter 1	SLC16A1	0.0172
844	Epidermal growth factor receptor	EGFR	0.0172
4203	Histamine N-methyltransferase	HNMT	0.0165
1341	Histamine H3 receptor	HRH3	0.0162
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0162
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0162
164	Histamine H4 receptor	HRH4	0.0162
6020	Aldehyde oxidase	AOX1	0.0158
777	Tumor necrosis factor	TNF	0.0157
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0157
6137	Multidrug resistance-associated protein 6	ABCC6	0.0156
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0155
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0155
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0153
504	Mast/stem cell growth factor receptor	KIT	0.0152
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0151
232	Corticosteroid-binding globulin	SERPINA6	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
122	P2Y purinoceptor 12	P2RY12	0.0148
952	Dipeptidyl peptidase 4	DPP4	0.0148
163	D(1B) dopamine receptor	DRD5	0.0147
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0146
818	50S ribosomal protein L10	rplJ	0.0144
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0144
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0143
6220	Aryl hydrocarbon receptor	AHR	0.0142
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.014
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0139
869	Estrogen receptor beta	ESR2	0.0138
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0138
159	Penicillin-binding protein 2B	penA	0.0137
6121	Penicillin-binding protein 2B	penA	0.0137
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0134
26	Vascular endothelial growth factor receptor 3	FLT4	0.0131
737	Mineralocorticoid receptor	NR3C2	0.0131
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0131
380	Cytochrome P450 17A1	CYP17A1	0.013
161	Tubulin beta chain	TUBB	0.0127
312	Tubulin beta chain	TUB2	0.0127
140	30S ribosomal protein S9	rpsI	0.0127
6719	30S ribosomal protein S9	rpsI	0.0127
6725	30S ribosomal protein S9	rpsI	0.0127
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0126
32	Vascular endothelial growth factor receptor 1	FLT1	0.0125
6014	Cytochrome P450 2A13	CYP2A13	0.0124
407	Vascular endothelial growth factor receptor 2	KDR	0.0124
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0122
373	Transthyretin	TTR	0.0121
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.012
131	Synaptic vesicular amine transporter	SLC18A2	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
672	Prostaglandin F2-alpha receptor	PTGFR	0.0118
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0118
1656	CYP2B protein	CYP2B	0.0116
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0115
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0115
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
571	Melatonin receptor type 1A	MTNR1A	0.0112
362	Melatonin receptor type 1B	MTNR1B	0.0112
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0112
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0112
1757	Myeloperoxidase	MPO	0.011
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.011
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.011
22	30S ribosomal protein S4	rpsD	0.0109
6714	30S ribosomal protein S4	rpsD	0.0109
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0107
4120	NADPH--cytochrome P450 reductase	POR	0.0106
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0106
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0106
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0105
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0105
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0105
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0105
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0105
1178	Adenosine A2a receptor	ADORA2A	0.0104
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0104
70	Type-1 angiotensin II receptor	AGTR1	0.0103
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0103
5626	Nucleoside diphosphate kinase B	NME2	0.0102
244	Angiotensin-converting enzyme	ACE	0.0101
16	Adenosine A1 receptor	ADORA1	0.01
6167	Organic solute transporter subunit beta	OSTB	0.0099
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0099
6166	Organic solute transporter subunit alpha	OSTA	0.0099
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0099
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0097
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0097
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4773	Deoxycytidine kinase	DCK	0.0097
94	5-hydroxytryptamine 4 receptor	HTR4	0.0096
811	Translocator protein	TSPO	0.0095
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0095
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
29	Tubulin beta-1 chain	TUBB1	0.0093
1517	Beta-3 adrenergic receptor	ADRB3	0.0093
1010	Cytochrome P450 51A1	CYP51A1	0.0093
645	Penicillin-binding protein 1A	mrcA	0.0091
5805	Penicillin-binding protein 1A	ponA	0.0091
6185	Penicillin-binding protein 1A	mrcA	0.0091
6799	Penicillin-binding protein 1A	pbpA	0.0091
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.009
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.009
1192	Sulfotransferase 1A1	SULT1A1	0.0089
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0089
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
4237	50S ribosomal protein L22	rplV	0.0087
543	Penicillin-binding protein 1B	mrcB	0.0086
6186	Penicillin-binding protein 1B	ponB	0.0086
6822	Penicillin-binding protein 1b	pbp1b	0.0086
6844	Penicillin-binding protein 1b	pbp1b	0.0086
273	Apoptosis regulator Bcl-2	BCL2	0.0085
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0084
2539	Tubulin alpha-1 chain	TUBA4A	0.0084
6171	Solute carrier family 28 member 3	SLC28A3	0.0084
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
5294	Nucleoside diphosphate kinase A	NME1	0.0083
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0083
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0083
6149	Solute carrier family 22 member 10	SLC22A10	0.0083
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0083
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0083
6432	Transporter	snf	0.0082
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0082
633	Penicillin-binding proteins 1A/1B	pbpA	0.0082
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0082
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0082
565	Extracellular calcium-sensing receptor	CASR	0.008
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.008
427	Substance-P receptor	TACR1	0.008
2112	Toll-like receptor 9	TLR9	0.008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.008
528	5-hydroxytryptamine 1E receptor	HTR1E	0.008
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0079
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0079
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0079
705	Glutamate receptor 1	GRIA1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0078
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0076
239	Coagulation factor X	F10	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0075
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0075
2472	Voltage-gated potassium channel	kcsA	0.0075
6366	Voltage-gated potassium channel	kcsA	0.0075
4238	50S ribosomal protein L4	rplD	0.0074
5578	50S ribosomal protein L4	rplD	0.0074
6173	50S ribosomal protein L4	rplD	0.0074
6219	50S ribosomal protein L4	rplD	0.0074
6102	Arylamine N-acetyltransferase 2	NAT2	0.0074
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0073
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
4122	Histone deacetylase 2	HDAC2	0.0073
5300	Antigen peptide transporter 1	TAP1	0.0072
275	Arachidonate 5-lipoxygenase	ALOX5	0.0072
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0071
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0071
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
1353	DNA topoisomerase 1	TOP1	0.007
3552	DNA topoisomerase 1	topA	0.007
511	5-hydroxytryptamine 1F receptor	HTR1F	0.007
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
33	Cystine/glutamate transporter	SLC7A11	0.0069
1618	High affinity nerve growth factor receptor	NTRK1	0.0069
183	Vascular endothelial growth factor A	VEGFA	0.0069
365	Dihydrofolate reductase	DHFR	0.0069
2381	Dihydrofolate reductase	DFR1	0.0069
2833	Dihydrofolate reductase	Not Available	0.0069
2931	Dihydrofolate reductase	folA	0.0069
3544	Dihydrofolate reductase	folA	0.0069
3682	Dihydrofolate reductase	folA	0.0069
6642	Dihydrofolate reductase	folA	0.0069
6756	Dihydrofolate reductase	dfrA	0.0069
2300	Lysozyme	E	0.0068
3633	Lysozyme	R	0.0068
5597	Lysozyme	17	0.0068
904	Glutathione S-transferase P	GSTP1	0.0067
6085	Fatty acid-binding protein, intestinal	FABP2	0.0067
723	Cytosolic phospholipase A2	PLA2G4A	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
768	FK506-binding protein 1A	FKBP1A	0.0067
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0067
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0067
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0066
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0066
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
6070	Nischarin	NISCH	0.0065
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0065
976	Platelet glycoprotein IX	GP9	0.0064
165	FL cytokine receptor	FLT3	0.0064
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4311	tRNA	TRDMT1	0.0063
4325	tRNA	trmD	0.0063
4328	tRNA	trmD	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
823	Fibroblast growth factor receptor 2	FGFR2	0.0062
814	Ryanodine receptor 1	RYR1	0.0062
592	Carbonic anhydrase 4	CA4	0.0062
153	Dopamine beta-hydroxylase	DBH	0.0061
357	Carbonic anhydrase 2	CA2	0.0061
284	DNA-directed RNA polymerase beta chain	rpoB	0.0061
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0061
5251	Carbonyl reductase [NADPH] 1	CBR1	0.006
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.006
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
6043	Putative G-protein coupled receptor 44	GPR44	0.0059
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0059
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0059
1830	5'-nucleotidase	NT5E	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0058
1852	Microtubule-associated protein 2	MAP2	0.0058
295	Carbonic anhydrase 1	CA1	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0058
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0058
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0057
6044	Serum paraoxonase/lactonase 3	PON3	0.0057
558	Solute carrier family 12 member 1	SLC12A1	0.0057
5126	Arginase	rocF	0.0057
1629	Transcription factor AP-1	JUN	0.0056
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0056
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0056
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0055
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0055
921	Glutamate receptor 2	GRIA2	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
319	Opioid receptor, sigma 1	OPRS1	0.0055
6506	Stathmin-4	STMN4	0.0055
594	Thyroxine-binding globulin	SERPINA7	0.0055
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0054
891	Dihydropteroate synthase	folP	0.0054
5359	Dihydropteroate synthase	folP	0.0054
7175	Dihydropteroate synthase	sulI	0.0054
5353	Glutamate decarboxylase alpha	gadA	0.0054
5998	Toll-like receptor 8	TLR8	0.0053
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0052
49	Endothelin B receptor	EDNRB	0.0052
712	Tubulin alpha chain	TUB1	0.0052
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0052
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0052
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0052
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0052
694	Matrix protein 2	M	0.0051
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0051
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0051
65	Matrix metalloproteinase-9	Not Available	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
758	Thyroid hormone receptor alpha	THRA	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.005
3932	Glutathione S-transferase A2	GSTA2	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.005
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.005
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.005
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.005
4103	Proteasome subunit beta type 2	PSMB2	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.005
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.005
578	Endothelin-1 receptor	EDNRA	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0048
3426	Glutamine synthetase	glnA	0.0048
3987	Glutamine synthetase	GLUL	0.0048
6146	High affinity copper uptake protein 1	SLC31A1	0.0048
3810	Catechol O-methyltransferase	COMT	0.0048
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0048
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0048
3856	Fibroblast growth factor receptor 3	FGFR3	0.0048
54	Prothrombin	F2	0.0048
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0047
1867	Major prion protein	PRNP	0.0047
1864	RET proto-oncogene	RET	0.0047
856	Vitamin D3 receptor	VDR	0.0047
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0047
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0047
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0047
1405	Thiopurine S-methyltransferase	TPMT	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
828	Phenylalanine-4-hydroxylase	PAH	0.0046
3109	Phenylalanine-4-hydroxylase	phhA	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
174	Sigma 1-type opioid receptor	SIGMAR1	0.0046
3086	Plasmepsin-2	Not Available	0.0046
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0046
624	Guanidinoacetate N-methyltransferase	GAMT	0.0046
6174	50S ribosomal protein L32	rpmF	0.0045
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0045
3611	Cytidine deaminase	cdd	0.0045
3707	Cytidine deaminase	cdd	0.0045
4211	Cytidine deaminase	CDA	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
346	Thyroid hormone receptor beta-1	THRB	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0044
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0044
1483	Membrane copper amine oxidase	AOC3	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
469	Annexin A1	ANXA1	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
130	Prostacyclin synthase	PTGIS	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
751	Potassium channel subfamily K member 6	KCNK6	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0042
908	Glutathione S-transferase theta-1	GSTT1	0.0041
518	Peroxidase/catalase T	katG	0.0041
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0041
125	DNA polymerase beta	POLB	0.0041
6209	30S ribosomal protein S19	rpsS	0.0041
6712	30S ribosomal protein S19	rpsS	0.0041
6726	30S ribosomal protein S19	rpsS	0.0041
6207	30S ribosomal protein S14	rpsN	0.0041
1050	Bile salt sulfotransferase	SULT2A1	0.0041
4192	DNA topoisomerase 2-beta	TOP2B	0.0041
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.004
6218	Pannexin-1	PANX1	0.0039
3587	Gastrotropin	FABP6	0.0039
3830	Calreticulin	CALR	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
5482	Sialidase-2	NEU2	0.0039
172	Potassium channel subfamily K member 1	KCNK1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
563	Thyroid peroxidase	TPO	0.0038
24	Thymidylate synthase	TMP1	0.0038
359	Thymidylate synthase	TYMS	0.0038
2626	Thymidylate synthase	thyA	0.0038
2729	Thymidylate synthase	thyA	0.0038
5352	Thymidylate synthase	THYA	0.0038
3957	Adenosine deaminase	ADA	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0038
3685	Catabolite gene activator	crp	0.0038
6824	Tyrosine-protein kinase Lyn	LYN	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
85	Growth hormone receptor	GHR	0.0038
4217	Telomerase reverse transcriptase	TERT	0.0037
992	Protein tyrosine kinase 2 beta	PTK2B	0.0037
482	Glycine receptor subunit alpha-1	GLRA1	0.0037
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0037
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0037
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0037
634	Squalene monooxygenase	SQLE	0.0036
7196	Squalene monooxygenase	ERG1	0.0036
6034	Hydroxyindole O-methyltransferase	ASMT	0.0036
6035	Nuclear receptor ROR-beta	RORB	0.0036
6036	Eosinophil peroxidase	EPX	0.0036
1630	Integrin beta-2	ITGB2	0.0036
780	Retinoic acid receptor RXR-gamma	RXRG	0.0036
5923	Microtubule-associated protein tau	MAPT	0.0036
5924	Microtubule-associated protein 4	MAP4	0.0036
5787	Angiopoietin-1 receptor	TEK	0.0035
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0035
115	Penicillin-binding protein 2	mrdA	0.0035
6069	Penicillin-binding protein 2	mrdA	0.0035
6118	Penicillin-binding protein 2	penA	0.0035
6187	Penicillin-binding protein 2	pbpA	0.0035
6686	Penicillin-binding protein 2	pbp2	0.0035
6939	Penicillin-binding protein 2	mrdA	0.0035
7163	Penicillin-binding protein 2	pbpA	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
939	50S ribosomal protein L3	rplC	0.0035
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0034
1196	Complement decay-accelerating factor	CD55	0.0034
936	Ephrin type-A receptor 2	EPHA2	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
6126	Carbonic anhydrase 7	CA7	0.0034
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0034
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0034
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0033
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
6151	Monocarboxylate transporter 10	SLC16A10	0.0033
1039	Histone deacetylase 9	HDAC9	0.0033
5682	Ribonuclease pancreatic	RNASE1	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
88	Retinoic acid receptor RXR-beta	RXRB	0.0033
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
4760	Mll3241 protein	mll3241	0.0032
702	UMP-CMP kinase	CMPK1	0.0032
1	Peptidoglycan synthetase ftsI	ftsI	0.0032
4155	Peptidoglycan synthetase ftsI	ftsI	0.0032
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
3809	Estrogen-related receptor gamma	ESRRG	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
581	Cytochrome P450 2R1	CYP2R1	0.0032
765	Indoleamine 2,3-dioxygenase	IDO1	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
84	Nuclear receptor 0B1	NR0B1	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
6168	Solute carrier family 22 member 16	SLC22A16	0.0031
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.003
7	Nitric oxide synthase, inducible	NOS2	0.003
2808	Chloramphenicol acetyltransferase 3	cat3	0.003
106	Cannabinoid receptor 2	CNR2	0.003
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.003
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.003
2320	Thymidine kinase, cytosolic	TK1	0.0029
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
489	Monocarboxylate transporter 2	SLC16A7	0.0029
527	Prostacyclin receptor	PTGIR	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
5934	Cytochrome P450 26A1	CYP26A1	0.0029
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0029
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0029
1525	Heparin-binding growth factor 2	FGF2	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0028
896	Glutathione S-transferase Mu 1	GSTM1	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
2021	Thrombomodulin	THBD	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0028
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0028
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0027
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0027
3601	Dihydropteroate synthase 1	folP1	0.0027
3807	Dihydropteroate synthase 1	folP1	0.0027
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
3808	Dihydropteroate synthase 2	folP2	0.0027
2417	Chloramphenicol acetyltransferase	cat	0.0027
3278	Chloramphenicol acetyltransferase	cat	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0027
572	Integrin alpha-L	ITGAL	0.0027
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
2810	Dr hemagglutinin structural subunit	draA	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6111	DNA polymerase epsilon subunit 4	POLE4	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
6112	DNA polymerase epsilon subunit 3	POLE3	0.0027
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0026
6110	DNA polymerase epsilon subunit 2	POLE2	0.0026
1654	Interleukin-1 beta	IL1B	0.0026
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
2216	Fibroblast growth factor receptor 4	FGFR4	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1648	Elastin	ELN	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
3913	Glutamic acid decarboxylase	GAD65	0.0026
6859	Protein S100-A4	S100A4	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
6165	Copper-transporting ATPase 1	ATP7A	0.0025
6163	Copper-transporting ATPase 2	ATP7B	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
1650	Heme carrier protein 1	SLC46A1	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0024
663	Solute carrier family 12 member 4	SLC12A4	0.0024
53	Solute carrier family 12 member 5	SLC12A5	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0024
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6048	Troponin C, skeletal muscle	TNNC2	0.0024
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
162	Retinoic acid receptor gamma-1	RARG	0.0023
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0023
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0023
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0023
310	Solute carrier family 12 member 2	SLC12A2	0.0023
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0023
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0023
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0023
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0023
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0023
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
517	Alcohol dehydrogenase 1C	ADH1C	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
494	Caspase-1	CASP1	0.0022
3404	Exotoxin A	eta	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
3904	Alanine aminotransferase 2	GPT2	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
298	Renin	REN	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1507	Cytochrome c	CYCS	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0021
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0021
6042	Prostaglandin reductase 2	PTGR2	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1992	Vitamin D-binding protein	GC	0.002
3937	Fatty-acid amide hydrolase	FAAH	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
603	DNA polymerase alpha catalytic subunit	POLA1	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
444	Alcohol dehydrogenase 1B	ADH1B	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
1792	Tissue-type plasminogen activator	PLAT	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
2077	Caspase-3	CASP3	0.0018
1253	Interferon gamma	IFNG	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
251	Alcohol dehydrogenase 1A	ADH1A	0.0018
1275	Estrogen sulfotransferase	SULT1E1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
819	Penicillin-binding protein 4	dacB	0.0017
291	Nitric-oxide synthase, endothelial	NOS3	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
820	Glycine receptor subunit alpha-2	GLRA2	0.0017
267	Plasminogen activator inhibitor 1	SERPINE1	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
3924	Phospholipase D1	PLD1	0.0016
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0016
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0016
1243	Cathepsin D	CTSD	0.0016
1313	Lactoylglutathione lyase	GLO1	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0015
3233	Bile acid receptor	NR1H4	0.0015
5818	Folate receptor alpha	FOLR1	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
277	Purine nucleoside phosphorylase	PNP	0.0015
2870	Purine nucleoside phosphorylase	punA	0.0015
2945	Purine nucleoside phosphorylase	punA	0.0015
4659	Purine nucleoside phosphorylase	TM_1596	0.0015
4825	Purine nucleoside phosphorylase	TTHA1435	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6221	Steroid hormone receptor ERR1	ESRRA	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
268	Adenosine A2b receptor	ADORA2B	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
2391	Ferrochelatase	hemH	0.0015
6502	Ferrochelatase	DKFZp686P18130	0.0015
1591	Ferrochelatase, mitochondrial	FECH	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
5798	Mitogen-activated protein kinase 11	MAPK11	0.0014
1541	Metalloproteinase	mmp20	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
293	Gamma-glutamyl hydrolase	GGH	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0013
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0013
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0013
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0013
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0013
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0013
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0013
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0013
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0013
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0013
6559	Cytochrome c oxidase subunit 2	ctaC	0.0013
6669	Cytochrome c oxidase subunit 2	ctaC	0.0013
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0013
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0013
6558	Cytochrome c oxidase subunit 1	ctaD	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0012
1295	Fatty acid synthase	FASN	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
2540	Choloylglycine hydrolase	cbh	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
6501	Fatty acid-binding protein, liver	FABP1	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
6459	Glycodelin	PAEP	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
569	Retinal dehydrogenase 2	ALDH1A2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2207	Rhodopsin	RHO	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6500	Phospholipase A2	PLA2G1B	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
76	Nitric-oxide synthase, brain	NOS1	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
798	Osteocalcin	BGLAP	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00863 - Ranitidine

Targets

Enzymes

Transporters

Predictions