DT-Web: DB01035

Identification

Name

Procainamide

Accession Number

DB01035 (APRD00509)

Type

small molecule

Description

A derivative of procaine with less CNS action. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

235.3253

Groups

approved

Monoisotopic Weight

235.168462309

Pharmacology

Indication

For the treatment of life-threatening ventricular arrhythmias.

Mechanism of action

Procainamide is sodium channel blocker. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Absorption

75 to 95%

Protein binding

15 to 20%

Biotransformation

Hepatic

Route of elimination

Trace amounts may be excreted in the urine as free and conjugated p-aminobenzoic acid, 30 to 60 percent as unchanged PA, and 6 to 52 percent as the NAPA derivative.

Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amiodarone	Amiodarone may increase serum levels and toxicity of procainamide.
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Cimetidine	The histamine H2-receptor antagonist, cimetidine, may increase the effect of procainamide.
Ciprofloxacin	Ciprofloxacin may increase the effect of procainamide.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Dihydroquinidine barbiturate	Quinidine increases the effect of procainamide
Donepezil	Possible antagonism of action
Fingolimod	Pharmacodynamic synergist. Contraindicated. Increased risk of bradycardia, AV block, and torsade de pointes.
Galantamine	Possible antagonism of action
Levofloxacin	Levofloxacin may increase the effect of procainamide.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Ofloxacin	Ofloxacin may increase the effect of procainamide.
Quinidine	Quinidine increases the effect of procainamide
Quinidine barbiturate	Quinidine increases the effect of procainamide
Ranitidine	The histamine H2-receptor antagonist, ranitidine, may increase the effect of procainamide.
Ranolazine	Possible additive effect on QT prolongation
Rivastigmine	Possible antagonism of action
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telavancin	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Procainamide. Consider alternate therapy or monitor for therapeutic/adverse effects of Procainamide if Terbinafine is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimethoprim	Trimethoprim may reduce the clearance of Procainamide. Alternative treatments should be considered. If Trimethoprim is initiated or the dose is increased, monitor for increased toxicity of Procainamide (e.g. QTc intervals, EKG, serum drug concentrations). If Trimethoprim is discontinued or the dose decreased, monitor for reduced effects of Procainamide.
Trimipramine	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Vardenafil	Increased risk of cardiotoxicity and arrhythmias
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take with food to reduce irritation.
Avoid alcohol.

Sodium channel protein type 5 subunit alpha
Name	Sodium channel protein type 5 subunit alpha
Gene Name	SCN5A
Pharmacological action	unknown
Actions	inhibitor
References	Weiss R, Barmada MM, Nguyen T, Seibel JS, Cavlovich D, Kornblit CA, Angelilli A, Villanueva F, McNamara DM, London B: Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3. Circulation. 2002 Feb 12;105(6):707-13. - Pubmed Brugada R, Brugada J, Antzelevitch C, Kirsch GE, Potenza D, Towbin JA, Brugada P: Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation. 2000 Feb 8;101(5):510-5. - Pubmed Chen SM, Kuo CT, Lin KH, Chiang FT: Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient. J Formos Med Assoc. 2000 Nov;99(11):860-2. - Pubmed Brugada J, Brugada R, Brugada P: [Brugada syndrome] Arch Mal Coeur Vaiss. 1999 Jul;92(7):847-50. - Pubmed Brugada J, Brugada P, Brugada R: The syndrome of right bundle branch block ST segment elevation in V1 to V3 and sudden death--the Brugada syndrome. Europace. 1999 Jul;1(3):156-66. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5155
DNA (cytosine-5)-methyltransferase 1
Name	DNA (cytosine-5)-methyltransferase 1
Gene Name	DNMT1
Pharmacological action	unknown
Actions	other
References	Oelke K, Lu Q, Richardson D, Wu A, Deng C, Hanash S, Richardson B: Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum. 2004 Jun;50(6):1850-60. - Pubmed Januchowski R, Jagodzinski PP: Effect of 5-azacytidine and procainamide on CD3-zeta chain expression in Jurkat T cells. Biomed Pharmacother. 2005 Apr;59(3):122-6. - Pubmed Lee BH, Yegnasubramanian S, Lin X, Nelson WG: Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005 Dec 9;280(49):40749-56. Epub 2005 Oct 17. - Pubmed Scheinbart LS, Johnson MA, Gross LA, Edelstein SR, Richardson BC: Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol. 1991 Apr;18(4):530-4. - Pubmed
DTHybrid score	0.682

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Lessard E, Hamelin BA, Labbe L, O'Hara G, Belanger PM, Turgeon J: Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics. 1999 Dec;9(6):683-96. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4107
Cholinesterase
Name	Cholinesterase
Gene Name	BCHE
Actions	inhibitor
References	- Bailey DN: Amitriptyline and procainamide inhibition of cocaine and cocaethylene degradation in human serum in vitro. J Anal Toxicol. 1999 Mar-Apr;23(2):99-102. - Pubmed Page JD, Wilson IB, Silman I: Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding. Mol Pharmacol. 1985 Apr;27(4):437-43. - Pubmed
DTHybrid score	0.6208

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. - Pubmed Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. - Pubmed Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. - Pubmed Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score	0.3466
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. - Pubmed Green RM, Lo K, Sterritt C, Beier DR: Cloning and functional expression of a mouse liver organic cation transporter. Hepatology. 1999 May;29(5):1556-62. - Pubmed Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM: Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 1997 Jun 27;272(26):16548-54. - Pubmed Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. - Pubmed Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994 Dec 8;372(6506):549-52. - Pubmed Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. - Pubmed
DTHybrid score	0.4144
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. - Pubmed
DTHybrid score	0.2682
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. - Pubmed Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score	0.3678
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	inhibitor
References	Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. - Pubmed
DTHybrid score	0.2817

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.2191
24	Thymidylate synthase	TMP1	0.2102
359	Thymidylate synthase	TYMS	0.2102
2626	Thymidylate synthase	thyA	0.2102
2729	Thymidylate synthase	thyA	0.2102
5352	Thymidylate synthase	THYA	0.2102
4200	Cytochrome P450 1A2	CYP1A2	0.1609
1588	Multidrug resistance protein 1	ABCB1	0.1607
3611	Cytidine deaminase	cdd	0.1593
3707	Cytidine deaminase	cdd	0.1593
4211	Cytidine deaminase	CDA	0.1593
4773	Deoxycytidine kinase	DCK	0.145
6016	Cytochrome P450 2C19	CYP2C19	0.1286
4757	Cytochrome P450 2C9	CYP2C9	0.1222
474	Acetylcholinesterase	ACHE	0.1221
4118	Cytochrome P450 3A5	CYP3A5	0.0928
6142	Solute carrier family 22 member 8	SLC22A8	0.0881
6030	Cytochrome P450 2B6	CYP2B6	0.0862
4924	Cytochrome P450 2C8	CYP2C8	0.0821
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0808
6107	Cytochrome P450 3A7	CYP3A7	0.0767
766	Beta-2 adrenergic receptor	ADRB2	0.0764
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0724
1729	Solute carrier family 22 member 6	SLC22A6	0.0693
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0687
1181	Alpha-1-acid glycoprotein 1	ORM1	0.068
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0671
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0659
6024	Cytochrome P450 1A1	CYP1A1	0.0651
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0644
492	Histamine H1 receptor	HRH1	0.064
6013	Cytochrome P450 2E1	CYP2E1	0.0608
587	Serum albumin	ALB	0.0605
556	Alpha-1A adrenergic receptor	ADRA1A	0.0584
862	Multidrug resistance-associated protein 1	ABCC1	0.0525
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0524
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0506
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0499
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0496
831	D(2) dopamine receptor	DRD2	0.0481
713	Sodium-dependent dopamine transporter	SLC6A3	0.0464
824	Sodium-dependent serotonin transporter	SLC6A4	0.0464
378	Alpha-2C adrenergic receptor	ADRA2C	0.0459
318	Alpha-2A adrenergic receptor	ADRA2A	0.0456
193	Beta-1 adrenergic receptor	ADRB1	0.0454
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0447
5718	Cytochrome P450 2A6	CYP2A6	0.0429
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0419
629	Alpha-2B adrenergic receptor	ADRA2B	0.0406
465	Calmodulin	CALM1	0.0405
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0392
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0374
124	Histamine H2 receptor	HRH2	0.037
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0356
1024	Solute carrier family 22 member 11	SLC22A11	0.0355
6106	Cytochrome P450 2C18	CYP2C18	0.0351
776	Bile salt export pump	ABCB11	0.0348
477	DNA topoisomerase 4 subunit A	parC	0.034
886	DNA topoisomerase 4 subunit A	parC	0.034
6226	DNA topoisomerase 4 subunit A	parC	0.034
404	DNA gyrase subunit A	gyrA	0.0334
6224	DNA gyrase subunit A	gyrA	0.0334
131	Synaptic vesicular amine transporter	SLC18A2	0.0333
632	Alpha-1B adrenergic receptor	ADRA1B	0.0317
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0313
23	D(1A) dopamine receptor	DRD1	0.0307
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0307
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0303
817	DNA topoisomerase 2-alpha	TOP2A	0.0297
6143	Solute carrier family 22 member 7	SLC22A7	0.0294
2472	Voltage-gated potassium channel	kcsA	0.0285
6366	Voltage-gated potassium channel	kcsA	0.0285
3941	Amine oxidase [flavin-containing] A	MAOA	0.0265
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
789	Alpha-1D adrenergic receptor	ADRA1D	0.0262
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0261
3939	Amine oxidase [flavin-containing] B	MAOB	0.0258
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0249
6010	Thiamine transporter 1	SLC19A2	0.0248
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0242
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0239
449	Ornithine decarboxylase	ODC1	0.0233
638	D(3) dopamine receptor	DRD3	0.0227
1636	Trace amine-associated receptor 1	TAAR1	0.0227
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0226
624	Guanidinoacetate N-methyltransferase	GAMT	0.0225
5126	Arginase	rocF	0.0223
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
172	Potassium channel subfamily K member 1	KCNK1	0.022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.022
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0217
2433	Capsid protein P40	UL80	0.0213
3569	Capsid protein P40	BVRF2	0.0213
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0211
3560	Gentamicin 3'-acetyltransferase	aacC1	0.021
3947	Xanthine dehydrogenase/oxidase	XDH	0.0209
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0208
20	Prostaglandin G/H synthase 1	PTGS1	0.0208
1898	Cytochrome P450 1B1	CYP1B1	0.0207
2429	Putrescine-binding periplasmic protein	potF	0.0206
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0199
2164	Multidrug resistance-associated protein 4	ABCC4	0.0195
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0191
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0191
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0191
2049	Gastrin/cholecystokinin type B receptor	CCKBR	0.0191
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0189
738	Monocarboxylate transporter 1	SLC16A1	0.0187
3076	Antigen 85-C	fbpC	0.0187
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0186
6148	Multidrug resistance-associated protein 7	ABCC10	0.0183
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0177
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0176
150	Cationic amino acid transporter 3	SLC7A3	0.0173
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0173
58	Cationic amino acid transporter 4	SLC7A4	0.0173
6070	Nischarin	NISCH	0.0172
4203	Histamine N-methyltransferase	HNMT	0.0171
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.017
7	Nitric oxide synthase, inducible	NOS2	0.0168
1757	Myeloperoxidase	MPO	0.0166
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0162
1341	Histamine H3 receptor	HRH3	0.0159
159	Penicillin-binding protein 2B	penA	0.0158
6121	Penicillin-binding protein 2B	penA	0.0158
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0158
164	Histamine H4 receptor	HRH4	0.0155
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0152
6137	Multidrug resistance-associated protein 6	ABCC6	0.0149
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0147
1517	Beta-3 adrenergic receptor	ADRB3	0.0147
2796	Parathion hydrolase	opd	0.0147
6539	Parathion hydrolase	opd	0.0147
432	D(4) dopamine receptor	DRD4	0.0144
6432	Transporter	snf	0.0144
5626	Nucleoside diphosphate kinase B	NME2	0.0143
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0142
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0142
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0142
769	High-affinity choline transporter 1	SLC5A7	0.0142
3927	Choline transporter-like protein 3	SLC44A3	0.0142
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0142
861	Choline kinase alpha	CHKA	0.0142
1686	Choline transporter-like protein 1	SLC44A1	0.0142
3926	Choline transporter-like protein 2	SLC44A2	0.0142
700	Choline dehydrogenase, mitochondrial	CHDH	0.0142
3925	Choline transporter-like protein 4	SLC44A4	0.0142
576	Choline O-acetyltransferase	CHAT	0.0142
3922	Phospholipase D2	PLD2	0.0142
3924	Phospholipase D1	PLD1	0.0142
303	Diamine acetyltransferase 2	SAT2	0.0141
6014	Cytochrome P450 2A13	CYP2A13	0.0141
1317	Spermine synthase	SMS	0.0141
623	Spermine oxidase	SMOX	0.0141
3454	Esterase	estA	0.0141
6136	Multidrug resistance-associated protein 5	ABCC5	0.014
2300	Lysozyme	E	0.0137
3633	Lysozyme	R	0.0137
5597	Lysozyme	17	0.0137
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0137
737	Mineralocorticoid receptor	NR3C2	0.0136
828	Phenylalanine-4-hydroxylase	PAH	0.0136
3109	Phenylalanine-4-hydroxylase	phhA	0.0136
163	D(1B) dopamine receptor	DRD5	0.0135
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0135
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0133
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0132
290	Prostaglandin G/H synthase 2	PTGS2	0.0132
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0132
3811	Cytochrome P450 19A1	CYP19A1	0.0132
847	Mu-type opioid receptor	OPRM1	0.0131
161	Tubulin beta chain	TUBB	0.0131
312	Tubulin beta chain	TUB2	0.0131
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0129
123	Diamine acetyltransferase 1	SAT1	0.0127
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0126
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
5682	Ribonuclease pancreatic	RNASE1	0.0125
2929	(S)-2-haloacid dehalogenase	dhlB	0.0124
2995	(S)-2-haloacid dehalogenase	Not Available	0.0124
6141	Sodium/bile acid cotransporter	SLC10A1	0.0124
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0123
380	Cytochrome P450 17A1	CYP17A1	0.0123
976	Platelet glycoprotein IX	GP9	0.0122
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0119
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0118
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0118
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0118
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0115
5294	Nucleoside diphosphate kinase A	NME1	0.0115
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0114
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0113
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0113
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0113
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0113
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0113
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0113
221	Lysyl-tRNA synthetase	KARS	0.0112
6151	Monocarboxylate transporter 10	SLC16A10	0.0111
244	Angiotensin-converting enzyme	ACE	0.0109
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0108
33	Cystine/glutamate transporter	SLC7A11	0.0107
751	Potassium channel subfamily K member 6	KCNK6	0.0107
467	Delta-type opioid receptor	OPRD1	0.0106
756	Sex hormone-binding globulin	SHBG	0.0104
633	Penicillin-binding proteins 1A/1B	pbpA	0.0104
4604	Liver carboxylesterase 1	CES1	0.0103
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0102
696	Kappa-type opioid receptor	OPRK1	0.0102
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0101
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.01
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0099
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0099
731	HIV-1 protease	HIV-1 protease	0.0099
6220	Aryl hydrocarbon receptor	AHR	0.0099
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0098
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0098
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0097
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0097
6146	High affinity copper uptake protein 1	SLC31A1	0.0095
577	Argininosuccinate lyase	ASL	0.0094
6165	Copper-transporting ATPase 1	ATP7A	0.0093
6163	Copper-transporting ATPase 2	ATP7B	0.0093
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0093
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0093
614	Progesterone receptor	PGR	0.0093
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
146	Androgen receptor	AR	0.0091
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.009
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.009
499	Arginine decarboxylase	ADC	0.0089
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0089
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0089
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0088
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0087
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0087
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0086
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0086
694	Matrix protein 2	M	0.0086
908	Glutathione S-transferase theta-1	GSTT1	0.0085
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0085
834	Arginase-2, mitochondrial	ARG2	0.0084
153	Dopamine beta-hydroxylase	DBH	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
136	Estrogen receptor	ESR1	0.0081
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
275	Arachidonate 5-lipoxygenase	ALOX5	0.0079
6168	Solute carrier family 22 member 16	SLC22A16	0.0079
904	Glutathione S-transferase P	GSTP1	0.0078
1830	5'-nucleotidase	NT5E	0.0077
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0077
740	Argininosuccinate synthase	ASS1	0.0076
865	Argininosuccinate synthase	ASS1	0.0076
2680	Argininosuccinate synthase	argG	0.0076
3194	Argininosuccinate synthase	argG	0.0076
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0076
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0075
896	Glutathione S-transferase Mu 1	GSTM1	0.0075
125	DNA polymerase beta	POLB	0.0074
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0074
338	DNA polymerase	UL30	0.0073
379	DNA polymerase	UL54	0.0073
697	DNA polymerase	ORF28	0.0073
2482	DNA polymerase	43	0.0073
4104	DNA polymerase	BALF5	0.0073
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0073
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0073
6031	Cytochrome P450 3A43	CYP3A43	0.0073
551	Carnitine O-acetyltransferase	CRAT	0.0073
645	Penicillin-binding protein 1A	mrcA	0.0073
5805	Penicillin-binding protein 1A	ponA	0.0073
6185	Penicillin-binding protein 1A	mrcA	0.0073
6799	Penicillin-binding protein 1A	pbpA	0.0073
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0072
702	UMP-CMP kinase	CMPK1	0.0072
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0071
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0071
1074	Urokinase-type plasminogen activator	PLAU	0.0071
844	Epidermal growth factor receptor	EGFR	0.007
6171	Solute carrier family 28 member 3	SLC28A3	0.007
921	Glutamate receptor 2	GRIA2	0.007
468	Cytochrome P450 4A11	CYP4A11	0.0068
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0068
1656	CYP2B protein	CYP2B	0.0066
3810	Catechol O-methyltransferase	COMT	0.0066
85	Growth hormone receptor	GHR	0.0065
860	Nicotinamide N-methyltransferase	NNMT	0.0064
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0064
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
699	Nicotinic acid receptor 1	GPR109A	0.0064
928	Nicotinic acid receptor 2	GPR109B	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0062
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0062
6138	Multidrug resistance protein 3	ABCB4	0.0061
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
788	Creatine kinase M-type	CKM	0.0057
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0056
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0056
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0056
291	Nitric-oxide synthase, endothelial	NOS3	0.0056
871	Glucocorticoid receptor	NR3C1	0.0055
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0055
1770	Phospholipase C	PLCL1	0.0055
2841	Phospholipase C	plc	0.0055
232	Corticosteroid-binding globulin	SERPINA6	0.0055
869	Estrogen receptor beta	ESR2	0.0054
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0054
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0051
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0051
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0049
1178	Adenosine A2a receptor	ADORA2A	0.0049
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0048
1353	DNA topoisomerase 1	TOP1	0.0047
3552	DNA topoisomerase 1	topA	0.0047
6218	Pannexin-1	PANX1	0.0047
29	Tubulin beta-1 chain	TUBB1	0.0046
4784	Beta-mannosidase	manB	0.0046
6695	Beta-mannosidase	BT_0458	0.0046
144	Hemoglobin subunit alpha	HBA1	0.0046
6131	Carbonic anhydrase 14	CA14	0.0045
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0045
504	Mast/stem cell growth factor receptor	KIT	0.0045
2112	Toll-like receptor 9	TLR9	0.0044
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0042
2539	Tubulin alpha-1 chain	TUBA4A	0.0042
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0042
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0041
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0041
1629	Transcription factor AP-1	JUN	0.004
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.004
500	Monocarboxylate transporter 4	SLC16A3	0.004
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0039
6212	Tubulin gamma-1 chain	TUBG1	0.0039
6210	Tubulin delta chain	TUBD1	0.0039
6211	Tubulin epsilon chain	TUBE1	0.0039
1864	RET proto-oncogene	RET	0.0038
6149	Solute carrier family 22 member 10	SLC22A10	0.0038
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0038
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0038
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0038
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0037
6085	Fatty acid-binding protein, intestinal	FABP2	0.0036
527	Prostacyclin receptor	PTGIR	0.0036
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0036
6167	Organic solute transporter subunit beta	OSTB	0.0036
6166	Organic solute transporter subunit alpha	OSTA	0.0036
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0036
723	Cytosolic phospholipase A2	PLA2G4A	0.0036
4787	Envelope glycoprotein gp160	env	0.0036
4820	Envelope glycoprotein gp160	env	0.0036
5727	Envelope glycoprotein gp160	env	0.0036
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0035
2297	Genome polyprotein	Not Available	0.0034
2322	Genome polyprotein	Not Available	0.0034
2694	Genome polyprotein	Not Available	0.0034
2719	Genome polyprotein	Not Available	0.0034
2860	Genome polyprotein	Not Available	0.0034
2928	Genome polyprotein	Not Available	0.0034
3160	Genome polyprotein	Not Available	0.0034
3260	Genome polyprotein	Not Available	0.0034
4783	Genome polyprotein	Not Available	0.0034
5726	Genome polyprotein	Not Available	0.0034
5779	Genome polyprotein	Not Available	0.0034
5867	Genome polyprotein	Not Available	0.0034
6253	Genome polyprotein	Not Available	0.0034
6301	Genome polyprotein	Not Available	0.0034
6380	Genome polyprotein	Not Available	0.0034
6381	Genome polyprotein	Not Available	0.0034
6437	Genome polyprotein	Not Available	0.0034
6520	Genome polyprotein	Not Available	0.0034
6521	Genome polyprotein	Not Available	0.0034
6652	Genome polyprotein	Not Available	0.0034
6734	Genome polyprotein	Not Available	0.0034
6735	Genome polyprotein	Not Available	0.0034
6736	Genome polyprotein	Not Available	0.0034
6737	Genome polyprotein	Not Available	0.0034
6738	Genome polyprotein	Not Available	0.0034
6739	Genome polyprotein	Not Available	0.0034
6744	Genome polyprotein	Not Available	0.0034
6748	Genome polyprotein	Not Available	0.0034
6894	Genome polyprotein	Not Available	0.0034
6898	Genome polyprotein	Not Available	0.0034
1618	High affinity nerve growth factor receptor	NTRK1	0.0034
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0033
6506	Stathmin-4	STMN4	0.0033
94	5-hydroxytryptamine 4 receptor	HTR4	0.0033
6182	Cytochrome P450 2J2	CYP2J2	0.0033
173	Toll-like receptor 7	TLR7	0.0033
357	Carbonic anhydrase 2	CA2	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
3426	Glutamine synthetase	glnA	0.0033
3987	Glutamine synthetase	GLUL	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0031
3437	Eosinophil lysophospholipase	CLC	0.003
4120	NADPH--cytochrome P450 reductase	POR	0.003
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.003
489	Monocarboxylate transporter 2	SLC16A7	0.003
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.003
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.003
716	5-hydroxytryptamine 7 receptor	HTR7	0.0029
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0028
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0028
565	Extracellular calcium-sensing receptor	CASR	0.0028
2449	Tubulin alpha-3 chain	TUBA1A	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
558	Solute carrier family 12 member 1	SLC12A1	0.0027
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0027
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0027
2207	Rhodopsin	RHO	0.0027
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0027
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0027
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0026
891	Dihydropteroate synthase	folP	0.0025
5359	Dihydropteroate synthase	folP	0.0025
7175	Dihydropteroate synthase	sulI	0.0025
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0024
4217	Telomerase reverse transcriptase	TERT	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
952	Dipeptidyl peptidase 4	DPP4	0.0024
6134	Sodium channel subunit beta-3	SCN3B	0.0024
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0024
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0024
6132	Sodium channel subunit beta-1	SCN1B	0.0024
6135	Sodium channel subunit beta-4	SCN4B	0.0024
6127	Carbonic anhydrase-related protein	CA8	0.0024
6133	Sodium channel subunit beta-2	SCN2B	0.0024
6128	Carbonic anhydrase-related protein 10	CA10	0.0024
6129	Carbonic anhydrase-related protein 11	CA11	0.0024
6126	Carbonic anhydrase 7	CA7	0.0024
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0023
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0023
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0022
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0022
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0022
4785	Ig gamma-1 chain C region	IGHG1	0.0022
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0021
295	Carbonic anhydrase 1	CA1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.002
6130	Carbonic anhydrase 13	CA13	0.002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.002
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.002
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.002
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.002
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.002
174	Sigma 1-type opioid receptor	SIGMAR1	0.002
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.002
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.002
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.002
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.002
365	Dihydrofolate reductase	DHFR	0.002
2381	Dihydrofolate reductase	DFR1	0.002
2833	Dihydrofolate reductase	Not Available	0.002
2931	Dihydrofolate reductase	folA	0.002
3544	Dihydrofolate reductase	folA	0.002
3682	Dihydrofolate reductase	folA	0.002
6642	Dihydrofolate reductase	folA	0.002
6756	Dihydrofolate reductase	dfrA	0.002
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0019
592	Carbonic anhydrase 4	CA4	0.0019
4192	DNA topoisomerase 2-beta	TOP2B	0.0019
2320	Thymidine kinase, cytosolic	TK1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0018
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0017
1039	Histone deacetylase 9	HDAC9	0.0017
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0017
3007	Carbonic anhydrase 12	CA12	0.0017
4205	Carbonic anhydrase 9	CA9	0.0017
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0016
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0016
4228	Keratin, type II cytoskeletal 7	KRT7	0.0016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0015
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0015
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0015
1050	Bile salt sulfotransferase	SULT2A1	0.0014
3086	Plasmepsin-2	Not Available	0.0014
373	Transthyretin	TTR	0.0014
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0014
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0014
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0014
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0014
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0013
3404	Exotoxin A	eta	0.0013
6020	Aldehyde oxidase	AOX1	0.0013
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0013
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0013
1010	Cytochrome P450 51A1	CYP51A1	0.0012
4498	Ornithine cyclodeaminase	PP3533	0.0012
3587	Gastrotropin	FABP6	0.0012
5449	Hypothetical gliding protein	mglB	0.0012
5443	UPF0189 protein ymdB	ymdB	0.0012
5440	UPF0067 protein yebR	yebR	0.0012
4705	Manganese catalase	Not Available	0.0012
5439	33 kDa chaperonin	hslO	0.0012
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0012
2720	Copper-containing nitrite reductase	nirK	0.0012
5448	Ribonuclease Z	rnz	0.0012
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0012
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0012
5454	Internalin-A	inlA	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0012
6102	Arylamine N-acetyltransferase 2	NAT2	0.0012
473	L-lactate dehydrogenase A chain	LDHA	0.0011
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0011
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0011
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0011
5450	Prolyl endopeptidase Pep	pep	0.0011
2290	ADP-ribosyl cyclase 2	BST1	0.001
3356	Diaminopimelate decarboxylase	lysA	0.001
407	Vascular endothelial growth factor receptor 2	KDR	0.001
597	Dihydropteridine reductase	QDPR	0.001
4771	Dissimilatory copper-containing nitrite reductase	nir	0.001
3274	Hydroxylamine reductase	hcp	0.001
4804	Hydroxylamine reductase	hcp	0.001
2714	Chorismate mutase	aroH	0.001
4611	Chorismate mutase	aroG	0.001
4311	tRNA	TRDMT1	0.001
4325	tRNA	trmD	0.001
4328	tRNA	trmD	0.001
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.001
260	Cytochrome P450 51	ERG11	0.001
761	Cytochrome P450 51	ERG11	0.001
3163	Cytochrome P450 51	cyp51	0.001
518	Peroxidase/catalase T	katG	0.001
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.001
3399	Limonene-1,2-epoxide hydrolase	limA	0.001
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.001
777	Tumor necrosis factor	TNF	0.0009
4608	Putative cytochrome P450	SCO1207	0.0009
4963	Putative cytochrome P450	SCO2884	0.0009
6254	Putative cytochrome P450	SCO6998	0.0009
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0009
563	Thyroid peroxidase	TPO	0.0009
5180	L(+)-mandelate dehydrogenase	mdlB	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
26	Vascular endothelial growth factor receptor 3	FLT4	0.0009
3500	Putative family 31 glucosidase yicI	yicI	0.0009
4878	Glycoprotein hormones alpha chain	CGA	0.0009
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0009
1072	Granzyme B	GZMB	0.0009
4889	Ig epsilon chain C region	IGHE	0.0009
4877	Beta-mannanase	man	0.0009
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0009
4189	Alpha-galactosidase A	GLA	0.0009
4850	Beta-2-glycoprotein 1	APOH	0.0009
4880	Membrane cofactor protein	CD46	0.0009
4856	CD209 antigen	CD209	0.0009
1354	Beta-glucuronidase	GUSB	0.0009
757	Fusion glycoprotein F0	F	0.0009
4875	Fusion glycoprotein F0	F	0.0009
4869	Major capsid protein	A430L	0.0009
4852	Reticulon-4 receptor	RTN4R	0.0009
4845	ADAM 33	ADAM33	0.0009
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0009
442	Envelope glycoprotein	gp41	0.0009
4859	Envelope glycoprotein	env	0.0009
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0009
4721	Beta-1,4-mannanase	manA	0.0009
3352	Structural polyprotein	Not Available	0.0009
3628	Structural polyprotein	Not Available	0.0009
4892	Structural polyprotein	Not Available	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
4122	Histone deacetylase 2	HDAC2	0.0009
16	Adenosine A1 receptor	ADORA1	0.0009
1615	Chymase	CMA1	0.0009
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0009
32	Vascular endothelial growth factor receptor 1	FLT1	0.0009
634	Squalene monooxygenase	SQLE	0.0009
7196	Squalene monooxygenase	ERG1	0.0009
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0009
1262	Corticotropin-lipotropin	POMC	0.0008
3932	Glutathione S-transferase A2	GSTA2	0.0008
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0008
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0008
1192	Sulfotransferase 1A1	SULT1A1	0.0008
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0008
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0008
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0008
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0008
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0008
165	FL cytokine receptor	FLT3	0.0008
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0008
4861	Interleukin-6 receptor alpha chain	IL6R	0.0008
793	T-cell surface antigen CD2	CD2	0.0008
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0008
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0008
3837	Cytokine receptor common beta chain	CSF2RB	0.0008
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0008
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0008
482	Glycine receptor subunit alpha-1	GLRA1	0.0008
70	Type-1 angiotensin II receptor	AGTR1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
122	P2Y purinoceptor 12	P2RY12	0.0007
581	Cytochrome P450 2R1	CYP2R1	0.0007
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0007
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0007
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0007
4890	Hemagglutinin	HA	0.0007
6566	Hemagglutinin	Not Available	0.0007
1379	Interleukin-12 subunit beta	IL12B	0.0007
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0007
6858	Inactive carboxylesterase 4	CES1P1	0.0007
1992	Vitamin D-binding protein	GC	0.0007
319	Opioid receptor, sigma 1	OPRS1	0.0007
1184	Interferon beta	IFNB1	0.0007
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0007
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0007
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0006
554	Low-density lipoprotein receptor	LDLR	0.0006
4103	Proteasome subunit beta type 2	PSMB2	0.0006
4102	Proteasome subunit beta type 5	PSMB5	0.0006
4101	Proteasome subunit beta type 1	PSMB1	0.0006
852	Heparin cofactor 2	SERPIND1	0.0006
1630	Integrin beta-2	ITGB2	0.0006
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
1859	Prostatic acid phosphatase	ACPP	0.0006
3444	Cyanovirin-N	Not Available	0.0006
3140	Hemagglutinin-neuraminidase	HN	0.0006
3609	Hemagglutinin-neuraminidase	HN	0.0006
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0006
595	Fibrinogen alpha chain	FGA	0.0006
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
705	Glutamate receptor 1	GRIA1	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0005
4666	Fucose-binding lectin PA-IIL	lecB	0.0005
2372	Bifunctional tail protein	9	0.0005
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0005
958	Insulin-like growth factor 1 receptor	IGF1R	0.0005
268	Adenosine A2b receptor	ADORA2B	0.0005
6044	Serum paraoxonase/lactonase 3	PON3	0.0005
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0005
856	Vitamin D3 receptor	VDR	0.0005
3814	Complement C1r subcomponent	C1R	0.0005
64	Neuraminidase	NA	0.0005
641	Neuraminidase	NA	0.0005
2676	Neuraminidase	NA	0.0005
3026	Neuraminidase	NA	0.0005
3519	Neuraminidase	NA	0.0005
6007	Neuraminidase	NA	0.0005
1243	Cathepsin D	CTSD	0.0005
183	Vascular endothelial growth factor A	VEGFA	0.0005
572	Integrin alpha-L	ITGAL	0.0005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0005
1439	Lactotransferrin	LTF	0.0005
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0005
309	Antithrombin-III	SERPINC1	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
6824	Tyrosine-protein kinase Lyn	LYN	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0004
760	Fibroblast growth factor 1	FGF1	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
2430	Chondroitinase B	cslB	0.0004
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0004
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0004
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0004
1268	Neuropeptide S receptor	NPSR1	0.0004
5787	Angiopoietin-1 receptor	TEK	0.0004
6307	Ig gamma-2 chain C region	IGHG2	0.0004
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0004
823	Fibroblast growth factor receptor 2	FGFR2	0.0004
2581	Chondroitinase AC	cslA	0.0004
6847	Lactase-phlorizin hydrolase	LCT	0.0004
5934	Cytochrome P450 26A1	CYP26A1	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6500	Phospholipase A2	PLA2G1B	0.0004
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
3937	Fatty-acid amide hydrolase	FAAH	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0004
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0004
84	Nuclear receptor 0B1	NR0B1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
3957	Adenosine deaminase	ADA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0003
469	Annexin A1	ANXA1	0.0003
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0003
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01035 - Procainamide

Targets

Enzymes

Transporters

Predictions