DT-Web

DB00665 - Nilutamide


Identification
Name Nilutamide
Accession Number DB00665 (APRD00150)
Type small molecule
Description Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 317.2207
Groups approved
Monoisotopic Weight 317.062340438
Pharmacology
Indication For use in combination with surgical castration for the treatment of metastatic prostate cancer involving distant lymph nodes, bone, or visceral organs (Stage D2).
Mechanism of action Nilutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. This blockade of androgen receptors may result in growth arrest or transient tumor regression through inhibition of androgen-dependent DNA and protein synthesis.
Absorption Rapidly and completely absorbed, yielding high and persistent plasma concentrations.
Protein binding Not Available
Biotransformation The results of a human metabolism study using 14C-radiolabelled tablets show that nilutamide is extensively metabolized and less than 2% of the drug is excreted unchanged in urine after 5 days.
Route of elimination Nilutamide is extensively metabolized andless than 2% of the drug is excreted unchanged in urine after 5 days. Fecal elimination is negligible, ranging from 1.4% to 7% of the dose after 4 to 5 days.
Toxicity Symptoms of overdose include dizziness, general discomfort, headache, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Nilutamide. Consider alternate therapy or monitor for adverse/toxic effects of Nilutamide if Ticlopidine is initiated, discontinued or dose changed.
Food Interactions
  • Take before breakfast.
  • Avoid alcohol.

Targets


Androgen receptor
Name Androgen receptor
Gene Name AR
Pharmacological action yes
Actions antagonist
References
  • Raynaud JP: Antiandrogens in combination with LH-RH agonists in prostate cancer. Am J Clin Oncol. 1988;11 Suppl 2:S132-47. - Pubmed
  • Moguilewsky M, Bertagna C, Hucher M: Pharmacological and clinical studies of the antiandrogen Anandron. J Steroid Biochem. 1987;27(4-6):871-5. - Pubmed
  • Raynaud JP, Bonne C, Moguilewsky M, Lefebvre FA, Belanger A, Labrie F: The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer: a review. Prostate. 1984;5(3):299-311. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Labrie F: Hormonal therapy of prostate cancer. Prog Brain Res. 2010;182:321-41. - Pubmed
  • Schasfoort EM, Van De Beek C, Newling DW: Safety and efficacy of a non-steroidal anti-androgen, based on results of a post marketing surveillance of nilutamide. Prostate Cancer Prostatic Dis. 2001;4(2):112-117. - Pubmed
  • Kaisary AV, Iversen P, Tyrrell CJ, Carroll K, Morris T: Is there a role for antiandrogen monotherapy in patients with metastatic prostate cancer? Prostate Cancer Prostatic Dis. 2001;4(4):196-203. - Pubmed
  • Kolvenbag GJ, Furr BJ, Blackledge GR: Receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity. Prostate Cancer Prostatic Dis. 1998 Dec;1(6):307-314. - Pubmed
  • Brawer MK, Crawford ED, Labrie F, Mendoza-Valdes A, Miller PD, Petrylak DP: Androgen deprivation and other treatments for advanced prostate cancer. Rev Urol. 2001;3 Suppl 2:S59-68. - Pubmed
DTHybrid score 1.0599

Enzymes


NADPH--cytochrome P450 reductase
Name NADPH--cytochrome P450 reductase
Gene Name POR
Actions substrate
References
  • -
  • Berger V, Berson A, Wolf C, Chachaty C, Fau D, Fromenty B, Pessayre D: Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen. Biochem Pharmacol. 1992 Feb 4;43(3):654-7. - Pubmed
DTHybrid score 0.2249
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3068
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2648
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3697

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2416
4119 Cytochrome P450 2D6 CYP2D6 0.1622
1588 Multidrug resistance protein 1 ABCB1 0.1397
4200 Cytochrome P450 1A2 CYP1A2 0.1284
6030 Cytochrome P450 2B6 CYP2B6 0.1191
4118 Cytochrome P450 3A5 CYP3A5 0.0998
3811 Cytochrome P450 19A1 CYP19A1 0.0817
6013 Cytochrome P450 2E1 CYP2E1 0.0784
6107 Cytochrome P450 3A7 CYP3A7 0.0762
20 Prostaglandin G/H synthase 1 PTGS1 0.0732
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0637
587 Serum albumin ALB 0.0602
5718 Cytochrome P450 2A6 CYP2A6 0.0541
6024 Cytochrome P450 1A1 CYP1A1 0.0535
290 Prostaglandin G/H synthase 2 PTGS2 0.0448
756 Sex hormone-binding globulin SHBG 0.0442
6106 Cytochrome P450 2C18 CYP2C18 0.0423
4079 Lipoic acid synthetase, mitochondrial LIAS 0.0397
45 Lipoyltransferase 1, mitochondrial LIPT1 0.0397
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0386
105 Sodium-dependent multivitamin transporter SLC5A6 0.038
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0349
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0348
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0348
614 Progesterone receptor PGR 0.0345
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0327
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0327
176 30S ribosomal protein S10 rpsJ 0.0325
6175 30S ribosomal protein S10 rpsJ 0.0325
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.0324
1898 Cytochrome P450 1B1 CYP1B1 0.0314
1729 Solute carrier family 22 member 6 SLC22A6 0.0312
737 Mineralocorticoid receptor NR3C2 0.0303
136 Estrogen receptor ESR1 0.03
862 Multidrug resistance-associated protein 1 ABCC1 0.0281
1181 Alpha-1-acid glycoprotein 1 ORM1 0.024
492 Histamine H1 receptor HRH1 0.0235
713 Sodium-dependent dopamine transporter SLC6A3 0.0235
3941 Amine oxidase [flavin-containing] A MAOA 0.0225
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0224
776 Bile salt export pump ABCB11 0.0224
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0223
871 Glucocorticoid receptor NR3C1 0.0223
847 Mu-type opioid receptor OPRM1 0.0222
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0221
824 Sodium-dependent serotonin transporter SLC6A4 0.022
6142 Solute carrier family 22 member 8 SLC22A8 0.0205
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0203
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0201
6144 Solute carrier family 22 member 2 SLC22A2 0.0193
556 Alpha-1A adrenergic receptor ADRA1A 0.0193
3939 Amine oxidase [flavin-containing] B MAOB 0.0193
3810 Catechol O-methyltransferase COMT 0.0177
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0175
2164 Multidrug resistance-associated protein 4 ABCC4 0.0175
318 Alpha-2A adrenergic receptor ADRA2A 0.0172
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.017
6137 Multidrug resistance-associated protein 6 ABCC6 0.0161
6145 Solute carrier family 22 member 1 SLC22A1 0.0156
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0156
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0155
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0154
260 Cytochrome P450 51 ERG11 0.0152
761 Cytochrome P450 51 ERG11 0.0152
3163 Cytochrome P450 51 cyp51 0.0152
891 Dihydropteroate synthase folP 0.015
5359 Dihydropteroate synthase folP 0.015
7175 Dihydropteroate synthase sulI 0.015
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0149
6143 Solute carrier family 22 member 7 SLC22A7 0.0149
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0148
131 Synaptic vesicular amine transporter SLC18A2 0.0148
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0147
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0146
731 HIV-1 protease HIV-1 protease 0.0145
502 5-hydroxytryptamine 2A receptor HTR2A 0.0144
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0144
817 DNA topoisomerase 2-alpha TOP2A 0.0143
6148 Multidrug resistance-associated protein 7 ABCC10 0.0141
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0138
122 P2Y purinoceptor 12 P2RY12 0.0136
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0135
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0134
381 Prolactin receptor PRLR 0.013
380 Cytochrome P450 17A1 CYP17A1 0.013
103 Muscarinic acetylcholine receptor M1 CHRM1 0.013
6241 Nuclear receptor coactivator 2 NCOA2 0.013
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.013
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.013
6031 Cytochrome P450 3A43 CYP3A43 0.0128
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0126
70 Type-1 angiotensin II receptor AGTR1 0.0125
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0123
831 D(2) dopamine receptor DRD2 0.0118
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0116
468 Cytochrome P450 4A11 CYP4A11 0.0115
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0115
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0109
766 Beta-2 adrenergic receptor ADRB2 0.0107
1024 Solute carrier family 22 member 11 SLC22A11 0.0107
341 5-hydroxytryptamine 3 receptor HTR3A 0.0107
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0104
696 Kappa-type opioid receptor OPRK1 0.0104
373 Transthyretin TTR 0.0102
3947 Xanthine dehydrogenase/oxidase XDH 0.0102
6182 Cytochrome P450 2J2 CYP2J2 0.0102
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0102
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0101
6220 Aryl hydrocarbon receptor AHR 0.0098
467 Delta-type opioid receptor OPRD1 0.0098
590 5-hydroxytryptamine 2C receptor HTR2C 0.0096
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0096
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0093
6141 Sodium/bile acid cotransporter SLC10A1 0.0093
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0093
365 Dihydrofolate reductase DHFR 0.0091
2381 Dihydrofolate reductase DFR1 0.0091
2833 Dihydrofolate reductase Not Available 0.0091
2931 Dihydrofolate reductase folA 0.0091
3544 Dihydrofolate reductase folA 0.0091
3682 Dihydrofolate reductase folA 0.0091
6642 Dihydrofolate reductase folA 0.0091
6756 Dihydrofolate reductase dfrA 0.0091
118 Organic cation/carnitine transporter 2 SLC22A5 0.0089
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0087
4116 Dihydropteroate synthetase Not Available 0.0087
6147 Solute carrier family 22 member 3 SLC22A3 0.0086
632 Alpha-1B adrenergic receptor ADRA1B 0.0086
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0086
23 D(1A) dopamine receptor DRD1 0.0085
76 Nitric-oxide synthase, brain NOS1 0.0084
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0084
465 Calmodulin CALM1 0.0083
6102 Arylamine N-acetyltransferase 2 NAT2 0.0083
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0082
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0082
6136 Multidrug resistance-associated protein 5 ABCC5 0.0081
4192 DNA topoisomerase 2-beta TOP2B 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
811 Translocator protein TSPO 0.0078
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0076
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0075
3923 Cholinesterase BCHE 0.0074
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0072
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
49 Endothelin B receptor EDNRB 0.007
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.007
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0068
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0068
844 Epidermal growth factor receptor EGFR 0.0068
833 Organic cation/carnitine transporter 1 SLC22A4 0.0067
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0066
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0066
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0066
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
504 Mast/stem cell growth factor receptor KIT 0.0065
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0064
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0064
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0063
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0063
133 Dihydropterate synthase sulI 0.0063
6014 Cytochrome P450 2A13 CYP2A13 0.0063
1649 Small inducible cytokine A2 CCL2 0.0063
1757 Myeloperoxidase MPO 0.0062
320 5-hydroxytryptamine 1A receptor HTR1A 0.0062
6085 Fatty acid-binding protein, intestinal FABP2 0.0061
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0061
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0061
1541 Metalloproteinase mmp20 0.006
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0059
777 Tumor necrosis factor TNF 0.0059
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0059
427 Substance-P receptor TACR1 0.0059
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0058
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0058
362 Melatonin receptor type 1B MTNR1B 0.0058
571 Melatonin receptor type 1A MTNR1A 0.0058
407 Vascular endothelial growth factor receptor 2 KDR 0.0058
592 Carbonic anhydrase 4 CA4 0.0058
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0058
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0057
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0057
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0057
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0057
124 Histamine H2 receptor HRH2 0.0056
4604 Liver carboxylesterase 1 CES1 0.0056
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0056
789 Alpha-1D adrenergic receptor ADRA1D 0.0055
193 Beta-1 adrenergic receptor ADRB1 0.0055
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
226 Gonadotropin-releasing hormone receptor GNRHR 0.0054
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0054
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0054
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0054
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0054
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0054
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0053
94 5-hydroxytryptamine 4 receptor HTR4 0.0053
1010 Cytochrome P450 51A1 CYP51A1 0.0053
6168 Solute carrier family 22 member 16 SLC22A16 0.0052
921 Glutamate receptor 2 GRIA2 0.0052
2159 Quinone oxidoreductase CRYZ 0.0052
295 Carbonic anhydrase 1 CA1 0.0051
869 Estrogen receptor beta ESR2 0.0051
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
885 5-hydroxytryptamine 1B receptor HTR1B 0.005
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.005
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.005
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.005
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.005
26 Vascular endothelial growth factor receptor 3 FLT4 0.005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.005
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0049
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0049
24 Thymidylate synthase TMP1 0.0048
359 Thymidylate synthase TYMS 0.0048
2626 Thymidylate synthase thyA 0.0048
2729 Thymidylate synthase thyA 0.0048
5352 Thymidylate synthase THYA 0.0048
183 Vascular endothelial growth factor A VEGFA 0.0048
7 Nitric oxide synthase, inducible NOS2 0.0048
32 Vascular endothelial growth factor receptor 1 FLT1 0.0048
275 Arachidonate 5-lipoxygenase ALOX5 0.0047
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0047
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
5073 Ferredoxin--NADP reductase petH 0.0046
5076 Ferredoxin--NADP reductase fpr 0.0046
5119 Ferredoxin--NADP reductase petH 0.0046
5121 Ferredoxin--NADP reductase fpr 0.0046
88 Retinoic acid receptor RXR-beta RXRB 0.0046
527 Prostacyclin receptor PTGIR 0.0045
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0045
5300 Antigen peptide transporter 1 TAP1 0.0045
638 D(3) dopamine receptor DRD3 0.0045
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0044
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0044
654 Flavin reductase BLVRB 0.0043
357 Carbonic anhydrase 2 CA2 0.0043
1275 Estrogen sulfotransferase SULT1E1 0.0042
228 Beta platelet-derived growth factor receptor PDGFRB 0.0042
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
29 Tubulin beta-1 chain TUBB1 0.0041
518 Peroxidase/catalase T katG 0.0041
4203 Histamine N-methyltransferase HNMT 0.0041
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0041
725 5-hydroxytryptamine 1D receptor HTR1D 0.004
738 Monocarboxylate transporter 1 SLC16A1 0.004
823 Fibroblast growth factor receptor 2 FGFR2 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
6126 Carbonic anhydrase 7 CA7 0.004
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0039
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
6174 50S ribosomal protein L32 rpmF 0.0038
4238 50S ribosomal protein L4 rplD 0.0038
5578 50S ribosomal protein L4 rplD 0.0038
6173 50S ribosomal protein L4 rplD 0.0038
6219 50S ribosomal protein L4 rplD 0.0038
161 Tubulin beta chain TUBB 0.0038
312 Tubulin beta chain TUB2 0.0038
1196 Complement decay-accelerating factor CD55 0.0038
291 Nitric-oxide synthase, endothelial NOS3 0.0038
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0038
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0037
1648 Elastin ELN 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0037
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0037
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0037
130 Prostacyclin synthase PTGIS 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0037
2539 Tubulin alpha-1 chain TUBA4A 0.0036
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0036
208 DNA-directed RNA polymerase beta' chain rpoC 0.0036
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0036
4503 NADPH-flavin oxidoreductase frp 0.0035
5189 Trimethylamine dehydrogenase tmd 0.0035
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0035
1618 High affinity nerve growth factor receptor NTRK1 0.0035
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0035
634 Squalene monooxygenase SQLE 0.0034
7196 Squalene monooxygenase ERG1 0.0034
5201 FMN-binding protein DvMF_2023 0.0034
5178 Protein nrdI nrdI 0.0034
3293 Flavodoxin Not Available 0.0034
4614 Flavodoxin DVU_2680 0.0034
5172 Flavodoxin isiB 0.0034
5173 Flavodoxin isiB 0.0034
5182 Flavodoxin fldA 0.0034
5198 Flavodoxin-1 fldA 0.0034
5170 Epidermin decarboxylase epiD 0.0034
5179 Probable aromatic acid decarboxylase pad1 0.0034
5175 Hypothetical protein SMU.260 SMU_260 0.0034
5202 Nitroreductase family protein BC_1844 0.0034
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0034
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0034
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0034
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0034
5131 PhzG phzG 0.0034
5181 Hypothetical protein yhdA azr 0.0034
5190 Rubredoxin-oxygen oxidoreductase roo 0.0034
5200 NADH dehydrogenase nox 0.0034
5191 Morphinone reductase morB 0.0034
5193 Phenazine biosynthesis protein phzG phzG 0.0034
4405 Nitric oxide reductase fprA 0.0034
1656 CYP2B protein CYP2B 0.0034
2808 Chloramphenicol acetyltransferase 3 cat3 0.0033
5880 Thrombopoietin receptor MPL 0.0033
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0032
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0032
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0032
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0032
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0032
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0032
444 Alcohol dehydrogenase 1B ADH1B 0.0032
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0031
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0031
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0031
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0031
5332 MtdA bifunctional protein mtdA 0.0031
5322 Oxidoreductase ydhF ydhF 0.0031
4403 Protein iolS iolS 0.0031
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0031
5330 General stress protein 69 yhdN 0.0031
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0031
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0031
3778 NAD(P) transhydrogenase subunit beta pntB 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
528 5-hydroxytryptamine 1E receptor HTR1E 0.0031
482 Glycine receptor subunit alpha-1 GLRA1 0.0031
629 Alpha-2B adrenergic receptor ADRA2B 0.0031
952 Dipeptidyl peptidase 4 DPP4 0.003
3808 Dihydropteroate synthase 2 folP2 0.003
3601 Dihydropteroate synthase 1 folP1 0.003
3807 Dihydropteroate synthase 1 folP1 0.003
408 Riboflavin kinase RFK 0.003
162 Retinoic acid receptor gamma-1 RARG 0.003
2417 Chloramphenicol acetyltransferase cat 0.003
3278 Chloramphenicol acetyltransferase cat 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
2810 Dr hemagglutinin structural subunit draA 0.003
4407 FMN-dependent NADH-azoreductase azoR 0.003
5169 FMN-dependent NADH-azoreductase azoR 0.003
5176 YtnJ moxC 0.003
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.003
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.003
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.003
3680 Dihydroorotate dehydrogenase A pyrDA 0.003
3809 Estrogen-related receptor gamma ESRRG 0.0029
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0029
4122 Histone deacetylase 2 HDAC2 0.0029
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0029
3507 Chorismate synthase aroC 0.0029
5171 Chorismate synthase aroC 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0029
4311 tRNA TRDMT1 0.0029
4325 tRNA trmD 0.0029
4328 tRNA trmD 0.0029
432 D(4) dopamine receptor DRD4 0.0029
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0029
581 Cytochrome P450 2R1 CYP2R1 0.0028
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0027
646 Malate dehydrogenase, cytoplasmic MDH1 0.0027
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0027
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
4582 Putative pteridine reductase 2 ptr2 0.0027
2775 Dihydroorotate dehydrogenase pyrD 0.0027
780 Retinoic acid receptor RXR-gamma RXRG 0.0027
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0027
6146 High affinity copper uptake protein 1 SLC31A1 0.0027
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0027
2286 Isocitrate dehydrogenase [NADP] icd 0.0027
2302 Isocitrate dehydrogenase [NADP] icd 0.0027
2771 Isocitrate dehydrogenase [NADP] icd 0.0027
5328 Prostaglandin F synthase Tb11.02.2310 0.0027
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0027
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0027
1992 Vitamin D-binding protein GC 0.0027
1050 Bile salt sulfotransferase SULT2A1 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
3446 NADP-dependent alcohol dehydrogenase adh 0.0027
2636 Shikimate dehydrogenase aroE 0.0027
3515 Shikimate dehydrogenase aroE 0.0027
729 GDP-L-fucose synthetase TSTA3 0.0027
3463 GDP-L-fucose synthetase fcl 0.0027
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0027
989 L-xylulose reductase DCXR 0.0027
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0027
84 Nuclear receptor 0B1 NR0B1 0.0026
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0026
319 Opioid receptor, sigma 1 OPRS1 0.0026
1192 Sulfotransferase 1A1 SULT1A1 0.0026
54 Prothrombin F2 0.0026
716 5-hydroxytryptamine 7 receptor HTR7 0.0026
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0026
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0026
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0026
666 NADP-dependent malic enzyme ME1 0.0026
5180 L(+)-mandelate dehydrogenase mdlB 0.0026
153 Dopamine beta-hydroxylase DBH 0.0026
1629 Transcription factor AP-1 JUN 0.0025
85 Growth hormone receptor GHR 0.0025
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0025
4531 Putative ketoacyl reductase actIII 0.0025
6297 Prostaglandin reductase 1 PTGR1 0.0025
976 Platelet glycoprotein IX GP9 0.0025
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0025
1630 Integrin beta-2 ITGB2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0025
4103 Proteasome subunit beta type 2 PSMB2 0.0025
4102 Proteasome subunit beta type 5 PSMB5 0.0025
4101 Proteasome subunit beta type 1 PSMB1 0.0025
273 Apoptosis regulator Bcl-2 BCL2 0.0025
3062 Aspartate-semialdehyde dehydrogenase asd 0.0025
469 Annexin A1 ANXA1 0.0024
6268 Hydroxyacid oxidase 1 HAO1 0.0024
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0024
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0024
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
229 Retinoic acid receptor beta RARB 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
1124 Sepiapterin reductase SPR 0.0024
2675 Pteridine reductase 1 PTR1 0.0023
4486 Phenol 2-hydroxylase component B pheA2 0.0023
4477 Dihydrolipoyl dehydrogenase lpdV 0.0023
5077 Dihydrolipoyl dehydrogenase Not Available 0.0023
5117 Dihydrolipoyl dehydrogenase lpd 0.0023
4439 Ferredoxin reductase bphA4 0.0023
16 Adenosine A1 receptor ADORA1 0.0023
4284 Pentaerythritol tetranitrate reductase onr 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
1178 Adenosine A2a receptor ADORA2A 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
239 Coagulation factor X F10 0.0023
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0023
3102 Flavohemoprotein hmp 0.0023
4969 Flavohemoprotein hmp 0.0023
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0023
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0023
5078 Amine oxidase, flavin-containing PSPTO1126 0.0022
5122 Mersacidin decarboxylase mrsD 0.0022
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0022
68 Cannabinoid receptor 1 CNR1 0.0022
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0022
3763 5,10-methylenetetrahydrofolate reductase metF 0.0022
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0022
5094 5,10-methylenetetrahydrofolate reductase metF 0.0022
5083 Cryptochrome DASH cry 0.0022
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0022
526 Thioredoxin reductase trxB 0.0022
3767 Thioredoxin reductase trxB 0.0022
5115 FkbI fkbI 0.0022
3133 UDP-galactopyranose mutase glf 0.0022
5099 UDP-galactopyranose mutase glf 0.0022
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0022
5095 Putidaredoxin reductase camA 0.0022
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0022
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0022
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0022
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0022
1410 Oxidoreductase HSD17B6 0.0022
4725 Oxidoreductase Not Available 0.0022
5124 Oxidoreductase Not Available 0.0022
5081 L-aspartate oxidase nadB 0.0022
5111 Phenylacetone monooxygenase pamO 0.0022
5109 Outer membrane protein p64k or PM-6 m-6 0.0022
563 Thyroid peroxidase TPO 0.0022
174 Sigma 1-type opioid receptor SIGMAR1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
3086 Plasmepsin-2 Not Available 0.0022
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0022
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0022
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0021
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0021
165 FL cytokine receptor FLT3 0.0021
5787 Angiopoietin-1 receptor TEK 0.0021
3913 Glutamic acid decarboxylase GAD65 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.002
605 Fumarate reductase flavoprotein subunit frdA 0.002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.002
3673 Fumarate reductase flavoprotein subunit fccA 0.002
4912 Fumarate reductase flavoprotein subunit ifcA 0.002
6549 Fumarate reductase flavoprotein subunit frdA 0.002
4440 NADH peroxidase npr 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
2021 Thrombomodulin THBD 0.002
856 Vitamin D3 receptor VDR 0.002
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.002
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.002
327 Glutathione reductase gor 0.002
5110 Glutathione reductase GR2 0.002
5072 N,N-dimethylglycine oxidase dmg 0.002
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.002
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.002
2268 Cholesterol oxidase choB 0.002
2822 Cholesterol oxidase choA 0.002
3594 Deoxyribodipyrimidine photo-lyase phr 0.002
5079 Deoxyribodipyrimidine photo-lyase phrB 0.002
5080 Deoxyribodipyrimidine photo-lyase phr 0.002
2470 Pyruvate oxidase pox5 0.0019
2526 NADPH-ferredoxin reductase fprA fprA 0.0019
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0019
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0019
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0019
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0019
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0019
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0019
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0019
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0019
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0019
572 Integrin alpha-L ITGAL 0.0019
1483 Membrane copper amine oxidase AOC3 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
267 Plasminogen activator inhibitor 1 SERPINE1 0.0019
164 Histamine H4 receptor HRH4 0.0019
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0019
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0019
126 D-lactate dehydrogenase dld 0.0018
3545 D-lactate dehydrogenase Not Available 0.0018
4510 D-lactate dehydrogenase ldhA 0.0018
1253 Interferon gamma IFNG 0.0018
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0018
3856 Fibroblast growth factor receptor 3 FGFR3 0.0018
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0018
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0018
2893 Glycine oxidase thiO 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
378 Alpha-2C adrenergic receptor ADRA2C 0.0018
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0017
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0017
6020 Aldehyde oxidase AOX1 0.0017
735 Alanine aminotransferase 1 GPT 0.0017
3904 Alanine aminotransferase 2 GPT2 0.0017
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
2567 Thymidylate synthase thyX thyX 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
2823 Trypanothione reductase TPR 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6218 Pannexin-1 PANX1 0.0017
3830 Calreticulin CALR 0.0017
6221 Steroid hormone receptor ERR1 ESRRA 0.0017
5934 Cytochrome P450 26A1 CYP26A1 0.0017
2769 P-hydroxybenzoate hydroxylase pobA 0.0017
2809 P-hydroxybenzoate hydroxylase pobA 0.0017
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
6432 Transporter snf 0.0016
489 Monocarboxylate transporter 2 SLC16A7 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
1256 5-hydroxytryptamine 6 receptor HTR6 0.0016
822 Aldose reductase AKR1B1 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
2380 Monomeric sarcosine oxidase soxA 0.0016
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
163 D(1B) dopamine receptor DRD5 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
6645 D-amino-acid oxidase DAO 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
511 5-hydroxytryptamine 1F receptor HTR1F 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0014
251 Alcohol dehydrogenase 1A ADH1A 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
714 Glutathione reductase, mitochondrial GSR 0.0013
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0013
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
820 Glycine receptor subunit alpha-2 GLRA2 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
284 DNA-directed RNA polymerase beta chain rpoB 0.0013
5773 DNA-directed RNA polymerase beta chain rpoB 0.0013
3932 Glutathione S-transferase A2 GSTA2 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
33 Cystine/glutamate transporter SLC7A11 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
474 Acetylcholinesterase ACHE 0.0011
1864 RET proto-oncogene RET 0.0011
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0011
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0011
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0011
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0011
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0011
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0011
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0011
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0011
2207 Rhodopsin RHO 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
283 SEC14-like protein 2 SEC14L2 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
3957 Adenosine deaminase ADA 0.0009
1341 Histamine H3 receptor HRH3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0008
6043 Putative G-protein coupled receptor 44 GPR44 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
4773 Deoxycytidine kinase DCK 0.0008
2599 Tyrosine-protein kinase HCK HCK 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
3221 Cytochrome c4 cc4 0.0007
1374 Natriuretic peptides B NPPB 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
1827 Gap junction alpha-1 protein GJA1 0.0007
1908 Vascular cell adhesion protein 1 VCAM1 0.0007
1517 Beta-3 adrenergic receptor ADRB3 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
1507 Cytochrome c CYCS 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4916 Cyanoglobin glbN 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4943 Cytochrome c6 petJ 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4984 Neuroglobin NGB 0.0004
4909 CooA protein cooA 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4961 Hemophore HasA hasA 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4910 Cytoglobin CYGB 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4972 P450cin cinA 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4952 Catalase/peroxidase katA 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
4920 Peroxidase/catalase katG 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
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