DT-Web

DB00086 - Streptokinase


Identification
Name Streptokinase
Accession Number DB00086 (BIOD00028, BTD00028)
Type biotech
Description Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 47286.7000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of acute evolving transmural myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis or emolism and occlusion of arteriovenous cannulae
Mechanism of action Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting cascade. Streptokinase forms a highly specific 1:1 enzymatic complex with plasminogen which converts inactive plasminogen molecules into active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. This in turn leads to the degradation of blood clots.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ticlopidine Increased bleeding risk. Monitor for signs of bleeding.
Food Interactions Not Available

Targets


Plasminogen
Name Plasminogen
Gene Name PLG
Pharmacological action yes
Actions activator
References
  • Caballero AR, Lottenberg R, Johnston KH: Cloning, expression, sequence analysis, and characterization of streptokinases secreted by porcine and equine isolates of Streptococcus equisimilis. Infect Immun. 1999 Dec;67(12):6478-86. - Pubmed
  • Alessi MC, Juhan-Vague I: [Thrombolytics and their use] Rev Prat. 1999 Oct 1;49(15):1654-8. - Pubmed
  • Chaudhary A, Vasudha S, Rajagopal K, Komath SS, Garg N, Yadav M, Mande SC, Sahni G: Function of the central domain of streptokinase in substrate plasminogen docking and processing revealed by site-directed mutagenesis. Protein Sci. 1999 Dec;8(12):2791-805. - Pubmed
  • Parry MA, Zhang XC, Bode I: Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues. Trends Biochem Sci. 2000 Feb;25(2):53-9. - Pubmed
  • Korol'chuk VI, Makohonenko IeM, Sederkhol'm-Vil'iams SA: [Plasminogen binding with decapeptide and polypeptide fragments of streptokinase] Ukr Biokhim Zh. 1999 Sep-Oct;71(5):51-8. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9165
Proteinase-activated receptor 1
Name Proteinase-activated receptor 1
Gene Name F2R
Pharmacological action unknown
Actions cleavage
References
  • McRedmond JP, Harriott P, Walker B, Fitzgerald DJ: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Blood. 2000 Feb 15;95(4):1301-8. - Pubmed
DTHybrid score 0.8343

Enzymes


Cytosolic phospholipase A2
Name Cytosolic phospholipase A2
Gene Name PLA2G4A
Actions inducer
References
  • Kawaguchi H, Iizuka K, Sano H, Yasuda H: Effect of streptokinase on prostacyclin synthesis and phospholipase activity in cultured pulmonary artery endothelial cells. Biochim Biophys Acta. 1990 Dec 10;1055(3):223-9. - Pubmed
DTHybrid score 0.7681

Predictions


Id Partner name Gene Name Score
791 Urokinase plasminogen activator surface receptor PLAUR 0.1841
267 Plasminogen activator inhibitor 1 SERPINE1 0.169
595 Fibrinogen alpha chain FGA 0.1553
2876 Membrane-bound lytic murein transglycosylase B mltB 0.0726
3133 UDP-galactopyranose mutase glf 0.0725
5099 UDP-galactopyranose mutase glf 0.0725
6020 Aldehyde oxidase AOX1 0.0677
1812 Kallikrein-1 KLK1 0.0676
2353 Apolipoprotein(a) LPA 0.0654
1792 Tissue-type plasminogen activator PLAT 0.062
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0573
1349 Plasminogen activator inhibitor 2 SERPINB2 0.0448
232 Corticosteroid-binding globulin SERPINA6 0.0432
871 Glucocorticoid receptor NR3C1 0.0368
6011 Chymotrypsinogen B CTRB1 0.0359
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.033
1729 Solute carrier family 22 member 6 SLC22A6 0.0315
6116 Gastric triacylglycerol lipase LIPF 0.0301
1757 Myeloperoxidase MPO 0.0301
1295 Fatty acid synthase FASN 0.028
3834 Nidogen-1 NID1 0.027
754 Pancreatic triacylglycerol lipase PNLIP 0.0268
4512 Cytochrome P450 3A4 CYP3A4 0.0268
3823 Cytokine receptor common gamma chain IL2RG 0.0254
3176 Trypsin-1 PRSS1 0.0248
3825 Tetranectin CLEC3B 0.0245
2111 Annexin A2 ANXA2 0.0245
3826 Keratin, type II cytoskeletal 8 KRT8 0.0245
3833 Plasma serine protease inhibitor SERPINA5 0.0235
3011 Suppressor of tumorigenicity protein 14 ST14 0.0225
4132 Chloride channel protein ClC-Ka CLCNKA 0.0225
724 Interleukin-2 receptor alpha chain IL2RA 0.0221
717 Interleukin-2 receptor subunit beta IL2RB 0.0221
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0219
1516 Calnexin CANX 0.0213
1770 Phospholipase C PLCL1 0.0206
2841 Phospholipase C plc 0.0206
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0206
4165 P2Y purinoceptor 2 P2RY2 0.0198
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0198
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.0197
3830 Calreticulin CALR 0.0189
430 Follicle-stimulating hormone receptor FSHR 0.0179
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0179
290 Prostaglandin G/H synthase 2 PTGS2 0.0177
817 DNA topoisomerase 2-alpha TOP2A 0.0173
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0171
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0165
2654 Complement control protein C3L 0.0161
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0154
862 Multidrug resistance-associated protein 1 ABCC1 0.0147
4118 Cytochrome P450 3A5 CYP3A5 0.0146
5455 Arylsulfatase A ARSA 0.0146
814 Ryanodine receptor 1 RYR1 0.0146
4203 Histamine N-methyltransferase HNMT 0.0143
6500 Phospholipase A2 PLA2G1B 0.0141
489 Monocarboxylate transporter 2 SLC16A7 0.0137
737 Mineralocorticoid receptor NR3C2 0.013
1074 Urokinase-type plasminogen activator PLAU 0.0124
2981 Phospholipase A2, membrane associated PLA2G2A 0.0119
614 Progesterone receptor PGR 0.0117
738 Monocarboxylate transporter 1 SLC16A1 0.0112
3947 Xanthine dehydrogenase/oxidase XDH 0.011
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0106
6144 Solute carrier family 22 member 2 SLC22A2 0.009
20 Prostaglandin G/H synthase 1 PTGS1 0.0083
54 Prothrombin F2 0.0081
6013 Cytochrome P450 2E1 CYP2E1 0.0077
6107 Cytochrome P450 3A7 CYP3A7 0.0077
1588 Multidrug resistance protein 1 ABCB1 0.0066
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