DT-Web

DB00215 - Citalopram


Identification
Name Citalopram
Accession Number DB00215 (APRD00147)
Type small molecule
Description Citalopram hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Citalopram and its N-demethylated metabolites exist as a racemic mixture but its effects are largely due to the S-enantiomer, S-citalopram and S-demthylcitalopram. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Citalopram is approved for treatment of depression. Unlabeled indications include mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy. Citalopram has the fewest drug-drug interactions of the SSRIs.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 324.3919
Groups approved
Monoisotopic Weight 324.163791509
Pharmacology
Indication For the treatment of depression. Unlabeled indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy.
Mechanism of action The antidepressant, antiobsessive-compulsive, and antibulimic actions of citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Absorption Rapidly and well absorbed from the GI tract. Peak plasma concentrations occur within 4 hours of a single orally administered dose. Bioavailability is 80% following oral administration. Food does not affect absorption.
Protein binding Citalopram, dimethylcitalopram, and didemethylcitalopram is 80% bound to plasma proteins.
Biotransformation Citalopram is metabolized mainly in the liver via N-demethylation to its principle metabolite, demethylcitalopram. Other metabolites include didemethylcitalopram, citalopram N-oxide, and a deaminated propionic acid derivative. However, the predominant entity in plasma is unchanged citalopram. Cytochrome P450 (CYP) 3A4 and 2C19 isozymes appear to be principally involved in producing demethylcitalopram. Demethylcitalopram appears to be further N-demethylated by CYP2D6 to didemethylcitalopram. Citalopram metabolites possess little pharmacologic activity in comparison to their parent compound and do not likely contribute to the clinical effect of the drug.
Route of elimination 12-23% of an oral dose of citalopram is recovered unchanged in the urine, while 10% of the dose is recovered in the feces.
Toxicity Symptoms most often accompanying citalopram overdose, alone or in combination with other drugs and/or alcohol, included dizziness, sweating, nausea, vomiting, tremor, somnolence, and sinus tachycardia. In more rare cases, observed symptoms included amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, and ECG changes (including QTc prolongation, nodal rhythm, ventricular arrhythmia, and very rare cases of torsade de pointes). Acute renal failure has been very rarely reported accompanying overdose. Withdrawal symptoms include flu-like symptoms, insomnia, nausea, imbalance, sensory changes and hyperactivity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The SSRI, citalopram, increases the effect of anticoagulant, acenocoumarol.
Almotriptan Increased risk of CNS adverse effects
Anisindione The SSRI, citalopram, increases the effect of anticoagulant, anisindione.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Carvedilol The SSRI, citalopram, may increase the bradycardic effect of the beta-blocker, carvedilol.
Clarithromycin Possible serotoninergic syndrome with this combination
Clozapine The antidepressant increases the effect of clozapine
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dicumarol The SSRI, citalopram, increases the effect of anticoagulant, dicumarol.
Eletriptan Increased risk of CNS adverse effects
Erythromycin Possible serotoninergic syndrome with this combination
Etravirine Citalopram, when used concomitantly with etravirine (a CYP2C19 inhibitor), may experience an increase in serum concentration. It is recommended to maintain the dose of citalopram below 20mg/day, and to monitor for toxicity. The symptoms which often accompany citalopram overdose are dizziness, sweating, nausea, vomiting, tremor, somnolence,sinus tachycardia,amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, acute renal failure, and ECG changes (including QTc prolongation, nodal rhythm, ventricular arrhythmia, and torsade de pointes).
Frovatriptan Increased risk of CNS adverse effects
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Isocarboxazid Possible severe adverse reaction with this combination
Josamycin Possible serotoninergic sydrome with this combination
Ketoprofen Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Linezolid Combination associated with possible serotoninergic syndrome
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Metoprolol The SSRI, citalopram, may increase the bradycardic effect of the beta-blocker, metoprolol.
Moclobemide Possible serotoninergic syndrome
Naratriptan Increased risk of CNS adverse effects
Oxycodone Increased risk of serotonin syndrome
Phenelzine Possible severe adverse reaction with this combination
Pimozide The SSRI, citalopram, may increase the effect and toxicity of pimozide.
Propranolol The SSRI, citalopram, may increase the bradycardic effect of the beta-blocker, propranolol.
Rasagiline Possible severe adverse reaction with this combination
Rizatriptan Increased risk of CNS adverse effects
Selegiline Possible severe adverse reaction with this combination
Sibutramine Risk of serotoninergic syndrome
St. John's Wort St. John's Wort increases the effect and toxicity of the SSRI, citalopram.
Sumatriptan Increased risk of CNS adverse effects
Telithromycin Telithromycin may reduce clearance of Citalopram. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Citalopram if Telithromycin is initiated, discontinued or dose changed.
Tiaprofenic acid Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Citalopram. Consider alternate therapy or monitor for adverse/toxic effects of Citalopram if Ticlopidine is initiated, discontinued or dose changed.
Tolmetin Increased antiplatelet effects may enhance the risk of bleeding. Alternate therapy may be considered or monitor for inreased bleeding during concomitant therapy.
Tramadol The use of two serotonin modulators, such as citalopram and tramadol, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Tranylcypromine Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Citalopram. Monitor for increased bleeding during concomitant thearpy.
Trimipramine The SSRI, Citalopram, may decrease the metabolism and clearance of Trimipramine. Increased risk of serotonin syndrome. Monitor for changes in Trimipramine efficacy and toxicity if Citalopram is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Citalopram, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Troleandomycin Possible serotoninergic syndrome with this combination
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of citalopram by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of citalopram if voriconazole is initiated, discontinued or dose changed.
Warfarin The SSRI, citalopram, increases the effect of anticoagulant, warfarin.
Ziprasidone Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Zolmitriptan The use of two serotonin modulators, such as zolmitriptan and citalopram, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.
  • Avoid St.John's Wort.
  • Avoid alcohol.

Targets


Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • Eriksson E, Engberg G, Bing O, Nissbrandt H: Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain. Neuropsychopharmacology. 1999 Mar;20(3):287-96. - Pubmed
  • Maines LW, Keck BJ, Smith JE, Lakoski JM: Corticosterone regulation of serotonin transporter and 5-HT1A receptor expression in the aging brain. Synapse. 1999 Apr;32(1):58-66. - Pubmed
  • Vicentic A, Battaglia G, Carroll FI, Kuhar MJ: Serotonin transporter production and degradation rates: studies with RTI-76. Brain Res. 1999 Sep 11;841(1-2):1-10. - Pubmed
  • Dugar A, Keck BJ, Maines LW, Miller S, Njai R, Lakoski JM: Compensatory responses in the aging hippocampal serotonergic system following neurodegenerative injury with 5,7-dihydroxytryptamine. Synapse. 2001 Feb;39(2):109-21. - Pubmed
  • Dutta AK, Fei XS, Beardsley PM, Newman JL, Reith ME: Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. J Med Chem. 2001 Mar 15;44(6):937-48. - Pubmed
  • Plenge P, Wiborg O: High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions. Neurosci Lett. 2005 Aug 5;383(3):203-8. Epub 2005 Apr 25. - Pubmed
  • Schloss P, Betz H: Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1. Biochemistry. 1995 Oct 3;34(39):12590-5. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
  • Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sanchez C: An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. Neurosci Lett. 2009 Oct 25;462(3):207-12. Epub 2009 Jul 16. - Pubmed
  • Rasmussen TN, Plenge P, Bay T, Egebjerg J, Gether U: A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation. Neuropharmacology. 2009 Sep;57(3):287-94. Epub 2009 Jun 3. - Pubmed
DTHybrid score 0.5297
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action unknown
Actions binder
References
  • Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score 0.681
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions binder
References
  • Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score 0.4542
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions binder
References
  • Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score 0.5154

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Brosen K, Naranjo CA: Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. Eur Neuropsychopharmacol. 2001 Aug;11(4):275-83. - Pubmed
  • Rasmussen BB, Brosen K: Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monit. 2000 Apr;22(2):143-54. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Pelkonen O, Maenpaa J, Taavitsainen P, Rautio A, Raunio H: Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica. 1998 Dec;28(12):1203-53. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8476
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Brosen K, Naranjo CA: Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. Eur Neuropsychopharmacol. 2001 Aug;11(4):275-83. - Pubmed
  • Rasmussen BB, Brosen K: Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monit. 2000 Apr;22(2):143-54. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Pelkonen O, Maenpaa J, Taavitsainen P, Rautio A, Raunio H: Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica. 1998 Dec;28(12):1203-53. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5057
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.8064
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3578
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5524
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.401

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed
  • Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Muller-Myhsok B, Holsboer F: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008 Jan 24;57(2):203-9. doi: 10.1016/j.neuron.2007.11.017. - Pubmed
DTHybrid score 0.5187
Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Actions substrate,inhibitor
References
  • Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score 0.6124
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Actions substrate,inhibitor
References
  • Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score 0.701
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Actions substrate,inhibitor
References
  • Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score 0.5297

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.4215
4924 Cytochrome P450 2C8 CYP2C8 0.2623
4118 Cytochrome P450 3A5 CYP3A5 0.2591
617 Muscarinic acetylcholine receptor M2 CHRM2 0.2163
51 Muscarinic acetylcholine receptor M3 CHRM3 0.205
318 Alpha-2A adrenergic receptor ADRA2A 0.2007
502 5-hydroxytryptamine 2A receptor HTR2A 0.1916
6107 Cytochrome P450 3A7 CYP3A7 0.1886
632 Alpha-1B adrenergic receptor ADRA1B 0.1812
6024 Cytochrome P450 1A1 CYP1A1 0.1603
5718 Cytochrome P450 2A6 CYP2A6 0.1465
831 D(2) dopamine receptor DRD2 0.1447
450 Muscarinic acetylcholine receptor M4 CHRM4 0.144
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1345
590 5-hydroxytryptamine 2C receptor HTR2C 0.129
3941 Amine oxidase [flavin-containing] A MAOA 0.1267
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1199
131 Synaptic vesicular amine transporter SLC18A2 0.1195
23 D(1A) dopamine receptor DRD1 0.1079
587 Serum albumin ALB 0.1067
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1005
320 5-hydroxytryptamine 1A receptor HTR1A 0.0998
789 Alpha-1D adrenergic receptor ADRA1D 0.0991
3939 Amine oxidase [flavin-containing] B MAOB 0.0956
766 Beta-2 adrenergic receptor ADRB2 0.0855
193 Beta-1 adrenergic receptor ADRB1 0.0832
6145 Solute carrier family 22 member 1 SLC22A1 0.0815
629 Alpha-2B adrenergic receptor ADRA2B 0.0791
20 Prostaglandin G/H synthase 1 PTGS1 0.076
6144 Solute carrier family 22 member 2 SLC22A2 0.0756
6106 Cytochrome P450 2C18 CYP2C18 0.0747
3923 Cholinesterase BCHE 0.0707
378 Alpha-2C adrenergic receptor ADRA2C 0.0673
436 5-hydroxytryptamine 2B receptor HTR2B 0.0635
118 Organic cation/carnitine transporter 2 SLC22A5 0.0633
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0608
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0586
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0583
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0581
341 5-hydroxytryptamine 3 receptor HTR3A 0.0564
3811 Cytochrome P450 19A1 CYP19A1 0.0554
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.055
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.055
862 Multidrug resistance-associated protein 1 ABCC1 0.0529
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0525
638 D(3) dopamine receptor DRD3 0.0507
1656 CYP2B protein CYP2B 0.0504
6147 Solute carrier family 22 member 3 SLC22A3 0.0497
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0488
432 D(4) dopamine receptor DRD4 0.047
1729 Solute carrier family 22 member 6 SLC22A6 0.0462
1898 Cytochrome P450 1B1 CYP1B1 0.0438
465 Calmodulin CALM1 0.0427
885 5-hydroxytryptamine 1B receptor HTR1B 0.0426
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0422
847 Mu-type opioid receptor OPRM1 0.0414
725 5-hydroxytryptamine 1D receptor HTR1D 0.0407
833 Organic cation/carnitine transporter 1 SLC22A4 0.0403
124 Histamine H2 receptor HRH2 0.0396
467 Delta-type opioid receptor OPRD1 0.0385
696 Kappa-type opioid receptor OPRK1 0.0384
1636 Trace amine-associated receptor 1 TAAR1 0.0384
260 Cytochrome P450 51 ERG11 0.0368
761 Cytochrome P450 51 ERG11 0.0368
3163 Cytochrome P450 51 cyp51 0.0368
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0365
776 Bile salt export pump ABCB11 0.036
290 Prostaglandin G/H synthase 2 PTGS2 0.0357
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0352
731 HIV-1 protease HIV-1 protease 0.0339
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0332
136 Estrogen receptor ESR1 0.0331
716 5-hydroxytryptamine 7 receptor HTR7 0.0326
871 Glucocorticoid receptor NR3C1 0.0322
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0314
6182 Cytochrome P450 2J2 CYP2J2 0.0311
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0289
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0288
817 DNA topoisomerase 2-alpha TOP2A 0.0287
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0287
163 D(1B) dopamine receptor DRD5 0.0287
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0279
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0277
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0272
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0272
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.027
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0268
468 Cytochrome P450 4A11 CYP4A11 0.0267
1256 5-hydroxytryptamine 6 receptor HTR6 0.0262
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0261
36 Insulin receptor INSR 0.0258
474 Acetylcholinesterase ACHE 0.0258
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0256
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0255
6432 Transporter snf 0.0252
6142 Solute carrier family 22 member 8 SLC22A8 0.0243
1517 Beta-3 adrenergic receptor ADRB3 0.024
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0238
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0238
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0238
4120 NADPH--cytochrome P450 reductase POR 0.0236
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0229
2164 Multidrug resistance-associated protein 4 ABCC4 0.0228
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0224
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0222
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0219
6143 Solute carrier family 22 member 7 SLC22A7 0.0216
1757 Myeloperoxidase MPO 0.0216
122 P2Y purinoceptor 12 P2RY12 0.021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0209
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0207
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0203
6031 Cytochrome P450 3A43 CYP3A43 0.0201
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0195
482 Glycine receptor subunit alpha-1 GLRA1 0.0194
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0193
94 5-hydroxytryptamine 4 receptor HTR4 0.0192
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0191
1341 Histamine H3 receptor HRH3 0.0189
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0188
528 5-hydroxytryptamine 1E receptor HTR1E 0.0182
477 DNA topoisomerase 4 subunit A parC 0.0181
886 DNA topoisomerase 4 subunit A parC 0.0181
6226 DNA topoisomerase 4 subunit A parC 0.0181
404 DNA gyrase subunit A gyrA 0.0178
6224 DNA gyrase subunit A gyrA 0.0178
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0177
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0177
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0172
777 Tumor necrosis factor TNF 0.017
4604 Liver carboxylesterase 1 CES1 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
6220 Aryl hydrocarbon receptor AHR 0.0165
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0164
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0163
16 Adenosine A1 receptor ADORA1 0.0162
818 50S ribosomal protein L10 rplJ 0.016
3947 Xanthine dehydrogenase/oxidase XDH 0.016
146 Androgen receptor AR 0.0159
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0158
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0155
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0153
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0153
380 Cytochrome P450 17A1 CYP17A1 0.0153
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0152
6148 Multidrug resistance-associated protein 7 ABCC10 0.0149
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0149
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0147
161 Tubulin beta chain TUBB 0.0146
312 Tubulin beta chain TUB2 0.0146
1178 Adenosine A2a receptor ADORA2A 0.0145
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0145
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0145
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0145
174 Sigma 1-type opioid receptor SIGMAR1 0.0145
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.014
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.014
504 Mast/stem cell growth factor receptor KIT 0.014
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0138
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0138
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0138
844 Epidermal growth factor receptor EGFR 0.0137
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0137
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0135
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0135
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0135
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0135
1010 Cytochrome P450 51A1 CYP51A1 0.0134
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0134
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0134
6137 Multidrug resistance-associated protein 6 ABCC6 0.0134
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0134
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0133
705 Glutamate receptor 1 GRIA1 0.0132
869 Estrogen receptor beta ESR2 0.0131
614 Progesterone receptor PGR 0.0131
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0129
537 ATP synthase delta chain, mitochondrial ATP5D 0.0127
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0127
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0126
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0126
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0125
6014 Cytochrome P450 2A13 CYP2A13 0.0124
6138 Multidrug resistance protein 3 ABCB4 0.0124
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0123
6136 Multidrug resistance-associated protein 5 ABCC5 0.0122
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0121
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.012
904 Glutathione S-transferase P GSTP1 0.0118
811 Translocator protein TSPO 0.0117
26 Vascular endothelial growth factor receptor 3 FLT4 0.0116
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0115
1618 High affinity nerve growth factor receptor NTRK1 0.0115
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0114
723 Cytosolic phospholipase A2 PLA2G4A 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0112
756 Sex hormone-binding globulin SHBG 0.0112
1275 Estrogen sulfotransferase SULT1E1 0.0112
1024 Solute carrier family 22 member 11 SLC22A11 0.0112
32 Vascular endothelial growth factor receptor 1 FLT1 0.0111
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.011
373 Transthyretin TTR 0.011
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0109
1360 Sphingomyelin phosphodiesterase SMPD1 0.0109
6141 Sodium/bile acid cotransporter SLC10A1 0.0108
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0108
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0108
1192 Sulfotransferase 1A1 SULT1A1 0.0107
6102 Arylamine N-acetyltransferase 2 NAT2 0.0107
407 Vascular endothelial growth factor receptor 2 KDR 0.0107
613 Atrial natriuretic peptide receptor A NPR1 0.0106
952 Dipeptidyl peptidase 4 DPP4 0.0106
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0105
891 Dihydropteroate synthase folP 0.0104
5359 Dihydropteroate synthase folP 0.0104
7175 Dihydropteroate synthase sulI 0.0104
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0104
828 Phenylalanine-4-hydroxylase PAH 0.0104
3109 Phenylalanine-4-hydroxylase phhA 0.0104
232 Corticosteroid-binding globulin SERPINA6 0.0103
319 Opioid receptor, sigma 1 OPRS1 0.0102
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
228 Beta platelet-derived growth factor receptor PDGFRB 0.0101
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.01
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0099
4122 Histone deacetylase 2 HDAC2 0.0098
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0097
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0096
571 Melatonin receptor type 1A MTNR1A 0.0096
362 Melatonin receptor type 1B MTNR1B 0.0096
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0096
70 Type-1 angiotensin II receptor AGTR1 0.0095
29 Tubulin beta-1 chain TUBB1 0.0094
921 Glutamate receptor 2 GRIA2 0.0092
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0092
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0087
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0087
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0085
6020 Aldehyde oxidase AOX1 0.0085
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0083
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0083
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0083
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0082
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0082
592 Carbonic anhydrase 4 CA4 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
427 Substance-P receptor TACR1 0.008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0079
173 Toll-like receptor 7 TLR7 0.0079
153 Dopamine beta-hydroxylase DBH 0.0078
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0078
295 Carbonic anhydrase 1 CA1 0.0078
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0078
365 Dihydrofolate reductase DHFR 0.0078
2381 Dihydrofolate reductase DFR1 0.0078
2833 Dihydrofolate reductase Not Available 0.0078
2931 Dihydrofolate reductase folA 0.0078
3544 Dihydrofolate reductase folA 0.0078
3682 Dihydrofolate reductase folA 0.0078
6642 Dihydrofolate reductase folA 0.0078
6756 Dihydrofolate reductase dfrA 0.0078
164 Histamine H4 receptor HRH4 0.0078
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0077
563 Thyroid peroxidase TPO 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
3810 Catechol O-methyltransferase COMT 0.0076
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
3932 Glutathione S-transferase A2 GSTA2 0.0075
444 Alcohol dehydrogenase 1B ADH1B 0.0073
4237 50S ribosomal protein L22 rplV 0.0073
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
183 Vascular endothelial growth factor A VEGFA 0.0072
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0072
2981 Phospholipase A2, membrane associated PLA2G2A 0.0071
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0071
251 Alcohol dehydrogenase 1A ADH1A 0.0071
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.007
511 5-hydroxytryptamine 1F receptor HTR1F 0.007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
284 DNA-directed RNA polymerase beta chain rpoB 0.0069
5773 DNA-directed RNA polymerase beta chain rpoB 0.0069
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0067
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0067
823 Fibroblast growth factor receptor 2 FGFR2 0.0067
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
814 Ryanodine receptor 1 RYR1 0.0065
737 Mineralocorticoid receptor NR3C2 0.0064
518 Peroxidase/catalase T katG 0.0063
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0063
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0062
2112 Toll-like receptor 9 TLR9 0.0062
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0061
357 Carbonic anhydrase 2 CA2 0.0061
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
6859 Protein S100-A4 S100A4 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
2539 Tubulin alpha-1 chain TUBA4A 0.0059
4203 Histamine N-methyltransferase HNMT 0.0059
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0058
4238 50S ribosomal protein L4 rplD 0.0058
5578 50S ribosomal protein L4 rplD 0.0058
6173 50S ribosomal protein L4 rplD 0.0058
6219 50S ribosomal protein L4 rplD 0.0058
273 Apoptosis regulator Bcl-2 BCL2 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6126 Carbonic anhydrase 7 CA7 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
856 Vitamin D3 receptor VDR 0.0058
2129 Sucrase-isomaltase, intestinal SI 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
738 Monocarboxylate transporter 1 SLC16A1 0.0057
517 Alcohol dehydrogenase 1C ADH1C 0.0056
1629 Transcription factor AP-1 JUN 0.0056
1374 Natriuretic peptides B NPPB 0.0056
1827 Gap junction alpha-1 protein GJA1 0.0056
1908 Vascular cell adhesion protein 1 VCAM1 0.0056
3426 Glutamine synthetase glnA 0.0056
3987 Glutamine synthetase GLUL 0.0056
4311 tRNA TRDMT1 0.0055
4325 tRNA trmD 0.0055
4328 tRNA trmD 0.0055
6506 Stathmin-4 STMN4 0.0055
65 Matrix metalloproteinase-9 Not Available 0.0054
239 Coagulation factor X F10 0.0054
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0052
49 Endothelin B receptor EDNRB 0.0052
712 Tubulin alpha chain TUB1 0.0052
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0052
3090 Chitosanase csn 0.0052
1048 Protein S100-A13 S100A13 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
2226 Protein S100-A12 S100A12 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
7 Nitric oxide synthase, inducible NOS2 0.005
6146 High affinity copper uptake protein 1 SLC31A1 0.005
1050 Bile salt sulfotransferase SULT2A1 0.005
6085 Fatty acid-binding protein, intestinal FABP2 0.005
4103 Proteasome subunit beta type 2 PSMB2 0.005
4102 Proteasome subunit beta type 5 PSMB5 0.005
4101 Proteasome subunit beta type 1 PSMB1 0.005
578 Endothelin-1 receptor EDNRA 0.0049
275 Arachidonate 5-lipoxygenase ALOX5 0.0049
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
3937 Fatty-acid amide hydrolase FAAH 0.0049
3404 Exotoxin A eta 0.0049
2132 Protein S100-B S100B 0.0049
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0049
6044 Serum paraoxonase/lactonase 3 PON3 0.0049
165 FL cytokine receptor FLT3 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0048
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0047
5300 Antigen peptide transporter 1 TAP1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1483 Membrane copper amine oxidase AOC3 0.0046
581 Cytochrome P450 2R1 CYP2R1 0.0046
1253 Interferon gamma IFNG 0.0046
976 Platelet glycoprotein IX GP9 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
3957 Adenosine deaminase ADA 0.0045
634 Squalene monooxygenase SQLE 0.0045
7196 Squalene monooxygenase ERG1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
908 Glutathione S-transferase theta-1 GSTT1 0.0045
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0045
4116 Dihydropteroate synthetase Not Available 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0043
117 Sterol O-acyltransferase 1 SOAT1 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0043
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
233 Potassium channel subfamily K member 2 KCNK2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.0042
84 Nuclear receptor 0B1 NR0B1 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
1852 Microtubule-associated protein 2 MAP2 0.0042
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0041
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0041
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0041
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0041
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0041
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0041
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0041
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0041
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0041
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0041
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.004
1262 Corticotropin-lipotropin POMC 0.004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.004
469 Annexin A1 ANXA1 0.0039
3856 Fibroblast growth factor receptor 3 FGFR3 0.0039
3809 Estrogen-related receptor gamma ESRRG 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
820 Glycine receptor subunit alpha-2 GLRA2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1630 Integrin beta-2 ITGB2 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0038
780 Retinoic acid receptor RXR-gamma RXRG 0.0038
85 Growth hormone receptor GHR 0.0038
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0036
5787 Angiopoietin-1 receptor TEK 0.0036
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
4192 DNA topoisomerase 2-beta TOP2B 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
88 Retinoic acid receptor RXR-beta RXRB 0.0034
1992 Vitamin D-binding protein GC 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
751 Potassium channel subfamily K member 6 KCNK6 0.0033
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0033
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0031
291 Nitric-oxide synthase, endothelial NOS3 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
3917 Methylenetetrahydrofolate reductase MTHFR 0.0031
33 Cystine/glutamate transporter SLC7A11 0.0031
3601 Dihydropteroate synthase 1 folP1 0.0031
3807 Dihydropteroate synthase 1 folP1 0.0031
3808 Dihydropteroate synthase 2 folP2 0.0031
6824 Tyrosine-protein kinase Lyn LYN 0.0031
5934 Cytochrome P450 26A1 CYP26A1 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
172 Potassium channel subfamily K member 1 KCNK1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
106 Cannabinoid receptor 2 CNR2 0.003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.003
6174 50S ribosomal protein L32 rpmF 0.0029
896 Glutathione S-transferase Mu 1 GSTM1 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0029
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0029
4773 Deoxycytidine kinase DCK 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
2298 Cytochrome P450-cam camC 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
6149 Solute carrier family 22 member 10 SLC22A10 0.0028
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
54 Prothrombin F2 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
6163 Copper-transporting ATPase 2 ATP7B 0.0027
6165 Copper-transporting ATPase 1 ATP7A 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0026
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
268 Adenosine A2b receptor ADORA2B 0.0026
1648 Elastin ELN 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0025
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0025
1268 Neuropeptide S receptor NPSR1 0.0025
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
162 Retinoic acid receptor gamma-1 RARG 0.0025
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0025
358 Cystathionine beta-synthase CBS 0.0025
5798 Mitogen-activated protein kinase 11 MAPK11 0.0025
1864 RET proto-oncogene RET 0.0024
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
2207 Rhodopsin RHO 0.0022
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
1039 Histone deacetylase 9 HDAC9 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
572 Integrin alpha-L ITGAL 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0019
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6459 Glycodelin PAEP 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
267 Plasminogen activator inhibitor 1 SERPINE1 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0019
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
4217 Telomerase reverse transcriptase TERT 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3830 Calreticulin CALR 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
229 Retinoic acid receptor beta RARB 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
6221 Steroid hormone receptor ERR1 ESRRA 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0016
6036 Eosinophil peroxidase EPX 0.0016
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
1243 Cathepsin D CTSD 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
3221 Cytochrome c4 cc4 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
3233 Bile acid receptor NR1H4 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
6755 Poliovirus receptor PVR 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
702 UMP-CMP kinase CMPK1 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
1541 Metalloproteinase mmp20 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
798 Osteocalcin BGLAP 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
6218 Pannexin-1 PANX1 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
2021 Thrombomodulin THBD 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
1295 Fatty acid synthase FASN 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
4920 Peroxidase/catalase katG 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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