DT-Web

DB00669 - Sumatriptan


Identification
Name Sumatriptan
Accession Number DB00669 (APRD00379)
Type small molecule
Description A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraine disorders. A transdermal patch version of sumatriptan is currently in phase I trials in the U.S. under the code name NP101 (NuPathe).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 295.4
Groups approved
Monoisotopic Weight 295.135447621
Pharmacology
Indication For the treatment of migraine attacks with or without aura.
Mechanism of action The 5-HT1B and 5-HT1D receptors function as autoreceptors, which inhibit the firing of serotonin neurons and a reduction in the synthesis and release of serotonin upon activation. After sumatriptan binds to these receptors, adenylate cyclase activity is inhibited via regulatory G proteins, incrases intracellular calcium, and affects other intracellular events. This results in vasoconstriction and inhibtion of sensory nociceptive (trigeminal) nerve firing and vasoactive neuropeptide release.
Absorption Approximately 15%
Protein binding 14%-21%
Biotransformation Hepatic. In vitro studies with human microsomes suggest that sumatriptan is metabolized by monoamine oxidase (MAO), predominantly the A isoenzyme.
Route of elimination Only 3% of the dose is excreted in the urine as unchanged sumatriptan; 42% of the dose is excreted as the major metabolite, the indole acetic acid analogue of sumatriptan.
Toxicity Symptoms of overdose include convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Citalopram Increased risk of CNS adverse effects
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroergotamine Possible severe and prolonged vasoconstriction
Ergotamine Possible severe and prolonged vasoconstriction
Escitalopram Increased risk of CNS adverse effects
Fluoxetine Increased risk of CNS adverse effects
Fluvoxamine Increased risk of CNS adverse effects
Isocarboxazid The MAO inhibitor, isocarboxazid, may decrease the metabolism and clearance of the serotonin 5-HT receptor agonist, sumatriptan. Concomitant therapy is contraindicated.
Lithium Possible serotoninergic syndrome with this combination
Methysergide Possible severe and prolonged vasoconstriction
Nefazodone Increased risk of CNS adverse effects
Paroxetine Increased risk of CNS adverse effects
Phenelzine The MAO inhibitor, phenelzine, may decrease the metabolism and clearance of the serotonin 5-HT receptor agonist, sumatriptan. Concomitant therapy is contraindicated.
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine The MAO inhibitor, Tranylcypromine, may reduce the metabolism and clearance of the serotonin 5-HT1D receptor agonist, Sumatriptan. Risk of serotonin syndrome and Sumatriptan toxicity. Concomitant therapy should be avoided.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Vilazodone Increased risk of serotonin syndrome
Zolmitriptan Concomitant use of two serotonin 5-HT1D receptor agonists, such as zolmitriptan and sumatriptan, may result in additive vasoconstrictive effects. Concomitant use within 24 hours is contraindicated.
Food Interactions Not Available

Targets


5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action yes
Actions agonist
References
  • Koran LM, Pallanti S, Quercioli L: Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2001 Apr;11(2):169-72. - Pubmed
  • Baxter LR Jr: Brain mediation of Anolis social dominance displays. III. Differential forebrain 3H-sumatriptan binding in dominant vs. submissive males. Brain Behav Evol. 2001 Apr;57(4):202-13. - Pubmed
  • Razzaque Z, Pickard JD, Ma QP, Shaw D, Morrison K, Wang T, Longmore J: 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan. Br J Clin Pharmacol. 2002 Mar;53(3):266-74. - Pubmed
  • Akin D, Gurdal H: Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery. Br J Pharmacol. 2002 May;136(2):177-82. - Pubmed
  • Zohar J, Kennedy JL, Hollander E, Koran LM: Serotonin-1D hypothesis of obsessive-compulsive disorder: an update. J Clin Psychiatry. 2004;65 Suppl 14:18-21. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Mitsikostas DD, Sanchez del Rio M, Moskowitz MA, Waeber C: Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis. Eur J Pharmacol. 1999 Mar 26;369(3):271-7. - Pubmed
  • Cohen ML, Schenck KW, Hemrick-Luecke SH: 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):1195-201. - Pubmed
  • Roy A, Brand NJ, Yacoub MH: Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves. J Heart Valve Dis. 2000 Mar;9(2):256-60; discussion 260-1. - Pubmed
  • Nikai T, Basbaum AI, Ahn AH: Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31;139(3):533-40. Epub 2008 Aug 23. - Pubmed
  • Mitsikostas DD, Sanchez del Rio M, Waeber C: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 2002 Jun;22(5):384-94. - Pubmed
DTHybrid score 0.4411
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action yes
Actions agonist
References
  • Dupuis DS, Perez M, Halazy S, Colpaert FC, Pauwels PJ: Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses. Brain Res Mol Brain Res. 1999 Apr 6;67(1):107-23. - Pubmed
  • Mitsikostas DD, Sanchez del Rio M, Moskowitz MA, Waeber C: Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis. Eur J Pharmacol. 1999 Mar 26;369(3):271-7. - Pubmed
  • Cohen ML, Schenck KW, Hemrick-Luecke SH: 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):1195-201. - Pubmed
  • Cohen Z, Bouchelet I, Olivier A, Villemure JG, Ball R, Stanimirovic DB, Hamel E: Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. J Cereb Blood Flow Metab. 1999 Aug;19(8):908-17. - Pubmed
  • Granas C, Larhammar D: Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor. Eur J Pharmacol. 1999 Sep 10;380(2-3):171-81. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Razzaque Z, Pickard JD, Ma QP, Shaw D, Morrison K, Wang T, Longmore J: 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan. Br J Clin Pharmacol. 2002 Mar;53(3):266-74. - Pubmed
  • Akin D, Gurdal H: Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery. Br J Pharmacol. 2002 May;136(2):177-82. - Pubmed
  • Roy A, Brand NJ, Yacoub MH: Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves. J Heart Valve Dis. 2000 Mar;9(2):256-60; discussion 260-1. - Pubmed
  • Nikai T, Basbaum AI, Ahn AH: Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31;139(3):533-40. Epub 2008 Aug 23. - Pubmed
  • Mitsikostas DD, Sanchez del Rio M, Waeber C: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 2002 Jun;22(5):384-94. - Pubmed
DTHybrid score 0.4681
5-hydroxytryptamine 1F receptor
Name 5-hydroxytryptamine 1F receptor
Gene Name HTR1F
Pharmacological action yes
Actions agonist
References
  • Razzaque Z, Heald MA, Pickard JD, Maskell L, Beer MS, Hill RG, Longmore J: Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47(1):75-82. - Pubmed
  • Pauwels PJ, John GW: Present and future of 5-HT receptor agonists as antimigraine drugs. Clin Neuropharmacol. 1999 May-Jun;22(3):123-36. - Pubmed
  • Cohen ML, Schenck K: Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha). Br J Pharmacol. 2000 Oct;131(3):562-8. - Pubmed
  • Janssen P, Tack J, Sifrim D, Meulemans AL, Lefebvre RA: Influence of 5-HT1 receptor agonists on feline stomach relaxation. Eur J Pharmacol. 2004 May 25;492(2-3):259-67. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Mitsikostas DD, Sanchez del Rio M, Moskowitz MA, Waeber C: Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis. Eur J Pharmacol. 1999 Mar 26;369(3):271-7. - Pubmed
  • Nikai T, Basbaum AI, Ahn AH: Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31;139(3):533-40. Epub 2008 Aug 23. - Pubmed
  • Mitsikostas DD, Sanchez del Rio M, Waeber C: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 2002 Jun;22(5):384-94. - Pubmed
DTHybrid score 0.4211
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action yes
Actions agonist
References
  • Johnson DE, Rollema H, Schmidt AW, McHarg AD: Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain. Eur J Pharmacol. 2001 Aug 17;425(3):203-10. - Pubmed
DTHybrid score 0.412

Enzymes


Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Actions substrate
References
  • -
  • Fox AW: Subcutaneous sumatriptan pharmacokinetics: delimiting the monoamine oxidase inhibitor effect. Headache. 2010 Feb;50(2):249-55. Epub 2009 Nov 17. - Pubmed
  • Fuseau E, Petricoul O, Moore KH, Barrow A, Ibbotson T: Clinical pharmacokinetics of intranasal sumatriptan. Clin Pharmacokinet. 2002;41(11):801-11. - Pubmed
DTHybrid score 0.5797

Transporters


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inducer
References
  • Lu R, Kanai N, Bao Y, Wolkoff AW, Schuster VL: Regulation of renal oatp mRNA expression by testosterone. Am J Physiol. 1996 Feb;270(2 Pt 2):F332-7. - Pubmed
DTHybrid score 0.2447
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.4169
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, van Veen HW: Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. Epub 2003 Mar 28. - Pubmed
DTHybrid score 0.2516
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Suzuki H, Sugiyama Y: Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver. Semin Liver Dis. 2000;20(3):251-63. - Pubmed
DTHybrid score 0.2619

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2714
4200 Cytochrome P450 1A2 CYP1A2 0.2334
4119 Cytochrome P450 2D6 CYP2D6 0.1924
3939 Amine oxidase [flavin-containing] B MAOB 0.1721
6016 Cytochrome P450 2C19 CYP2C19 0.1408
4757 Cytochrome P450 2C9 CYP2C9 0.1333
502 5-hydroxytryptamine 2A receptor HTR2A 0.1306
4118 Cytochrome P450 3A5 CYP3A5 0.1271
318 Alpha-2A adrenergic receptor ADRA2A 0.1271
4924 Cytochrome P450 2C8 CYP2C8 0.1196
831 D(2) dopamine receptor DRD2 0.1175
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1108
436 5-hydroxytryptamine 2B receptor HTR2B 0.1075
629 Alpha-2B adrenergic receptor ADRA2B 0.1038
378 Alpha-2C adrenergic receptor ADRA2C 0.0985
23 D(1A) dopamine receptor DRD1 0.0985
590 5-hydroxytryptamine 2C receptor HTR2C 0.0983
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0963
638 D(3) dopamine receptor DRD3 0.0956
6107 Cytochrome P450 3A7 CYP3A7 0.0931
432 D(4) dopamine receptor DRD4 0.0868
556 Alpha-1A adrenergic receptor ADRA1A 0.0859
587 Serum albumin ALB 0.084
716 5-hydroxytryptamine 7 receptor HTR7 0.0764
163 D(1B) dopamine receptor DRD5 0.0743
862 Multidrug resistance-associated protein 1 ABCC1 0.0719
193 Beta-1 adrenergic receptor ADRB1 0.066
632 Alpha-1B adrenergic receptor ADRA1B 0.0652
6145 Solute carrier family 22 member 1 SLC22A1 0.0612
824 Sodium-dependent serotonin transporter SLC6A4 0.0588
6030 Cytochrome P450 2B6 CYP2B6 0.0584
766 Beta-2 adrenergic receptor ADRB2 0.0575
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0569
6013 Cytochrome P450 2E1 CYP2E1 0.0563
1729 Solute carrier family 22 member 6 SLC22A6 0.0552
776 Bile salt export pump ABCB11 0.0546
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0546
6024 Cytochrome P450 1A1 CYP1A1 0.0542
528 5-hydroxytryptamine 1E receptor HTR1E 0.0535
6142 Solute carrier family 22 member 8 SLC22A8 0.0532
5718 Cytochrome P450 2A6 CYP2A6 0.0467
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0451
6141 Sodium/bile acid cotransporter SLC10A1 0.0444
492 Histamine H1 receptor HRH1 0.0442
540 Sodium-dependent noradrenaline transporter SLC6A2 0.044
713 Sodium-dependent dopamine transporter SLC6A3 0.0392
789 Alpha-1D adrenergic receptor ADRA1D 0.0382
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.038
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0378
20 Prostaglandin G/H synthase 1 PTGS1 0.0376
6144 Solute carrier family 22 member 2 SLC22A2 0.0362
2164 Multidrug resistance-associated protein 4 ABCC4 0.0359
6143 Solute carrier family 22 member 7 SLC22A7 0.0333
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0331
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0322
1517 Beta-3 adrenergic receptor ADRB3 0.0321
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0321
1898 Cytochrome P450 1B1 CYP1B1 0.0313
341 5-hydroxytryptamine 3 receptor HTR3A 0.0302
1256 5-hydroxytryptamine 6 receptor HTR6 0.0291
33 Cystine/glutamate transporter SLC7A11 0.0288
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.028
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0279
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0275
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0275
1024 Solute carrier family 22 member 11 SLC22A11 0.0272
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0263
617 Muscarinic acetylcholine receptor M2 CHRM2 0.026
118 Organic cation/carnitine transporter 2 SLC22A5 0.0257
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0255
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0254
3587 Gastrotropin FABP6 0.0252
3811 Cytochrome P450 19A1 CYP19A1 0.0249
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0247
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0246
136 Estrogen receptor ESR1 0.0241
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0226
731 HIV-1 protease HIV-1 protease 0.0221
6148 Multidrug resistance-associated protein 7 ABCC10 0.0218
94 5-hydroxytryptamine 4 receptor HTR4 0.0208
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0205
871 Glucocorticoid receptor NR3C1 0.0204
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0203
6147 Solute carrier family 22 member 3 SLC22A3 0.0203
1353 DNA topoisomerase 1 TOP1 0.0202
3552 DNA topoisomerase 1 topA 0.0202
3810 Catechol O-methyltransferase COMT 0.0196
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0191
131 Synaptic vesicular amine transporter SLC18A2 0.019
146 Androgen receptor AR 0.0184
844 Epidermal growth factor receptor EGFR 0.0184
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0179
70 Type-1 angiotensin II receptor AGTR1 0.0178
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0178
833 Organic cation/carnitine transporter 1 SLC22A4 0.0177
6106 Cytochrome P450 2C18 CYP2C18 0.0172
244 Angiotensin-converting enzyme ACE 0.0171
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0171
904 Glutathione S-transferase P GSTP1 0.017
758 Thyroid hormone receptor alpha THRA 0.0169
6137 Multidrug resistance-associated protein 6 ABCC6 0.0166
756 Sex hormone-binding globulin SHBG 0.0158
869 Estrogen receptor beta ESR2 0.0155
817 DNA topoisomerase 2-alpha TOP2A 0.0153
6167 Organic solute transporter subunit beta OSTB 0.0152
6166 Organic solute transporter subunit alpha OSTA 0.0152
504 Mast/stem cell growth factor receptor KIT 0.0151
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0151
346 Thyroid hormone receptor beta-1 THRB 0.0151
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0149
3923 Cholinesterase BCHE 0.0149
738 Monocarboxylate transporter 1 SLC16A1 0.0148
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0147
4604 Liver carboxylesterase 1 CES1 0.0147
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0143
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0141
594 Thyroxine-binding globulin SERPINA7 0.014
26 Vascular endothelial growth factor receptor 3 FLT4 0.0138
32 Vascular endothelial growth factor receptor 1 FLT1 0.0132
290 Prostaglandin G/H synthase 2 PTGS2 0.0131
117 Sterol O-acyltransferase 1 SOAT1 0.0129
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0129
847 Mu-type opioid receptor OPRM1 0.0128
373 Transthyretin TTR 0.0127
468 Cytochrome P450 4A11 CYP4A11 0.0125
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0123
6136 Multidrug resistance-associated protein 5 ABCC5 0.0123
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
407 Vascular endothelial growth factor receptor 2 KDR 0.012
3917 Methylenetetrahydrofolate reductase MTHFR 0.012
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0118
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0117
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0117
228 Beta platelet-derived growth factor receptor PDGFRB 0.0115
6031 Cytochrome P450 3A43 CYP3A43 0.0111
1757 Myeloperoxidase MPO 0.0109
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
29 Tubulin beta-1 chain TUBB1 0.0107
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0106
4120 NADPH--cytochrome P450 reductase POR 0.0106
5698 Riboflavin synthase alpha chain ribE 0.0105
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0104
737 Mineralocorticoid receptor NR3C2 0.0103
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0103
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0102
408 Riboflavin kinase RFK 0.0101
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0098
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0098
6599 HTH-type transcriptional regulator ttgR ttgR 0.0097
2539 Tubulin alpha-1 chain TUBA4A 0.0097
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
124 Histamine H2 receptor HRH2 0.009
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0089
380 Cytochrome P450 17A1 CYP17A1 0.0089
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0088
4773 Deoxycytidine kinase DCK 0.0087
1656 CYP2B protein CYP2B 0.0084
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
469 Annexin A1 ANXA1 0.0082
5880 Thrombopoietin receptor MPL 0.0081
467 Delta-type opioid receptor OPRD1 0.008
199 Monocarboxylate transporter 8 SLC16A2 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
696 Kappa-type opioid receptor OPRK1 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
3947 Xanthine dehydrogenase/oxidase XDH 0.0076
654 Flavin reductase BLVRB 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
1650 Heme carrier protein 1 SLC46A1 0.0074
6182 Cytochrome P450 2J2 CYP2J2 0.0074
275 Arachidonate 5-lipoxygenase ALOX5 0.0071
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0071
3856 Fibroblast growth factor receptor 3 FGFR3 0.0071
6220 Aryl hydrocarbon receptor AHR 0.007
474 Acetylcholinesterase ACHE 0.007
1192 Sulfotransferase 1A1 SULT1A1 0.0065
4238 50S ribosomal protein L4 rplD 0.0064
5578 50S ribosomal protein L4 rplD 0.0064
6173 50S ribosomal protein L4 rplD 0.0064
6219 50S ribosomal protein L4 rplD 0.0064
1760 Aminopeptidase N ANPEP 0.0064
6843 Aminopeptidase N pepN 0.0064
6149 Solute carrier family 22 member 10 SLC22A10 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6014 Cytochrome P450 2A13 CYP2A13 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
4237 50S ribosomal protein L22 rplV 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
6085 Fatty acid-binding protein, intestinal FABP2 0.0059
293 Gamma-glutamyl hydrolase GGH 0.0058
5787 Angiopoietin-1 receptor TEK 0.0058
3809 Estrogen-related receptor gamma ESRRG 0.0057
6151 Monocarboxylate transporter 10 SLC16A10 0.0057
908 Glutathione S-transferase theta-1 GSTT1 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0056
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0056
161 Tubulin beta chain TUBB 0.0055
312 Tubulin beta chain TUB2 0.0055
1630 Integrin beta-2 ITGB2 0.0055
260 Cytochrome P450 51 ERG11 0.0055
761 Cytochrome P450 51 ERG11 0.0055
3163 Cytochrome P450 51 cyp51 0.0055
952 Dipeptidyl peptidase 4 DPP4 0.0055
165 FL cytokine receptor FLT3 0.0054
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0054
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0054
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0054
1852 Microtubule-associated protein 2 MAP2 0.0053
24 Thymidylate synthase TMP1 0.0052
359 Thymidylate synthase TYMS 0.0052
2626 Thymidylate synthase thyA 0.0052
2729 Thymidylate synthase thyA 0.0052
5352 Thymidylate synthase THYA 0.0052
273 Apoptosis regulator Bcl-2 BCL2 0.0052
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0052
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
164 Histamine H4 receptor HRH4 0.0051
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.005
232 Corticosteroid-binding globulin SERPINA6 0.005
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0048
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0048
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0048
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0047
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
465 Calmodulin CALM1 0.0046
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0046
768 FK506-binding protein 1A FKBP1A 0.0046
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0046
6163 Copper-transporting ATPase 2 ATP7B 0.0045
6165 Copper-transporting ATPase 1 ATP7A 0.0045
6044 Serum paraoxonase/lactonase 3 PON3 0.0045
1618 High affinity nerve growth factor receptor NTRK1 0.0045
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
6146 High affinity copper uptake protein 1 SLC31A1 0.0043
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0043
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0043
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0043
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
1525 Heparin-binding growth factor 2 FGF2 0.0042
3913 Glutamic acid decarboxylase GAD65 0.0042
572 Integrin alpha-L ITGAL 0.0042
5818 Folate receptor alpha FOLR1 0.0041
1291 cAMP response element-binding protein CREB1 0.0041
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0041
1636 Trace amine-associated receptor 1 TAAR1 0.0041
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
5923 Microtubule-associated protein tau MAPT 0.0041
5924 Microtubule-associated protein 4 MAP4 0.0041
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0041
614 Progesterone receptor PGR 0.0041
4210 Toll-like receptor 4 TLR4 0.0041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.004
1502 Peroxisome proliferator-activated receptor delta PPARD 0.004
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.004
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0039
6168 Solute carrier family 22 member 16 SLC22A16 0.0039
1483 Membrane copper amine oxidase AOC3 0.0039
563 Thyroid peroxidase TPO 0.0038
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0038
4122 Histone deacetylase 2 HDAC2 0.0038
896 Glutathione S-transferase Mu 1 GSTM1 0.0038
106 Cannabinoid receptor 2 CNR2 0.0037
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0037
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0036
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0036
6020 Aldehyde oxidase AOX1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
239 Coagulation factor X F10 0.0035
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0035
4192 DNA topoisomerase 2-beta TOP2B 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
751 Potassium channel subfamily K member 6 KCNK6 0.0035
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
760 Fibroblast growth factor 1 FGF1 0.0034
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
365 Dihydrofolate reductase DHFR 0.0034
2381 Dihydrofolate reductase DFR1 0.0034
2833 Dihydrofolate reductase Not Available 0.0034
2931 Dihydrofolate reductase folA 0.0034
3544 Dihydrofolate reductase folA 0.0034
3682 Dihydrofolate reductase folA 0.0034
6642 Dihydrofolate reductase folA 0.0034
6756 Dihydrofolate reductase dfrA 0.0034
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0033
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0032
172 Potassium channel subfamily K member 1 KCNK1 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0031
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0031
2391 Ferrochelatase hemH 0.0031
6502 Ferrochelatase DKFZp686P18130 0.0031
1591 Ferrochelatase, mitochondrial FECH 0.0031
823 Fibroblast growth factor receptor 2 FGFR2 0.003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.003
702 UMP-CMP kinase CMPK1 0.003
976 Platelet glycoprotein IX GP9 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.003
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
183 Vascular endothelial growth factor A VEGFA 0.003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
6824 Tyrosine-protein kinase Lyn LYN 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0029
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0029
683 Potassium transporter GK0582 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0028
1010 Cytochrome P450 51A1 CYP51A1 0.0028
7 Nitric oxide synthase, inducible NOS2 0.0028
489 Monocarboxylate transporter 2 SLC16A7 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
84 Nuclear receptor 0B1 NR0B1 0.0028
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0027
284 DNA-directed RNA polymerase beta chain rpoB 0.0027
5773 DNA-directed RNA polymerase beta chain rpoB 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0027
6493 Cytochrome c oxidase subunit 6C COX6C 0.0027
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0027
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0027
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0027
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0027
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0027
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0027
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0027
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0027
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0027
6559 Cytochrome c oxidase subunit 2 ctaC 0.0027
6669 Cytochrome c oxidase subunit 2 ctaC 0.0027
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0027
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0027
6558 Cytochrome c oxidase subunit 1 ctaD 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6837 Serine/threonine-protein kinase 17B STK17B 0.0025
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0025
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
153 Dopamine beta-hydroxylase DBH 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
2540 Choloylglycine hydrolase cbh 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
2021 Thrombomodulin THBD 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0024
2216 Fibroblast growth factor receptor 4 FGFR4 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
4217 Telomerase reverse transcriptase TERT 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0022
605 Fumarate reductase flavoprotein subunit frdA 0.0022
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0022
3673 Fumarate reductase flavoprotein subunit fccA 0.0022
4912 Fumarate reductase flavoprotein subunit ifcA 0.0022
6549 Fumarate reductase flavoprotein subunit frdA 0.0022
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
5626 Nucleoside diphosphate kinase B NME2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
6133 Sodium channel subunit beta-2 SCN2B 0.002
6134 Sodium channel subunit beta-3 SCN3B 0.002
6132 Sodium channel subunit beta-1 SCN1B 0.002
6135 Sodium channel subunit beta-4 SCN4B 0.002
6127 Carbonic anhydrase-related protein CA8 0.002
6129 Carbonic anhydrase-related protein 11 CA11 0.002
6128 Carbonic anhydrase-related protein 10 CA10 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
2240 Cell division protein kinase 2 CDK2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
5934 Cytochrome P450 26A1 CYP26A1 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0019
6218 Pannexin-1 PANX1 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
6500 Phospholipase A2 PLA2G1B 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0018
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0018
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0018
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0018
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0018
6130 Carbonic anhydrase 13 CA13 0.0018
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0018
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0018
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0018
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0018
1864 RET proto-oncogene RET 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0017
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
5294 Nucleoside diphosphate kinase A NME1 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
6131 Carbonic anhydrase 14 CA14 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6043 Putative G-protein coupled receptor 44 GPR44 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0016
6122 Carbonic anhydrase 3 CA3 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0016
2981 Phospholipase A2, membrane associated PLA2G2A 0.0015
6755 Poliovirus receptor PVR 0.0015
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0015
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1629 Transcription factor AP-1 JUN 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6126 Carbonic anhydrase 7 CA7 0.0013
295 Carbonic anhydrase 1 CA1 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
6432 Transporter snf 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
592 Carbonic anhydrase 4 CA4 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
427 Substance-P receptor TACR1 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.001
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3957 Adenosine deaminase ADA 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
4439 Ferredoxin reductase bphA4 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5095 Putidaredoxin reductase camA 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5081 L-aspartate oxidase nadB 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
1410 Oxidoreductase HSD17B6 0.0008
4725 Oxidoreductase Not Available 0.0008
5124 Oxidoreductase Not Available 0.0008
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0008
357 Carbonic anhydrase 2 CA2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
4440 NADH peroxidase npr 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
327 Glutathione reductase gor 0.0007
5110 Glutathione reductase GR2 0.0007
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
3594 Deoxyribodipyrimidine photo-lyase phr 0.0007
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0007
5080 Deoxyribodipyrimidine photo-lyase phr 0.0007
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
5072 N,N-dimethylglycine oxidase dmg 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
2470 Pyruvate oxidase pox5 0.0007
5073 Ferredoxin--NADP reductase petH 0.0007
5076 Ferredoxin--NADP reductase fpr 0.0007
5119 Ferredoxin--NADP reductase petH 0.0007
5121 Ferredoxin--NADP reductase fpr 0.0007
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0007
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0007
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0007
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0007
2268 Cholesterol oxidase choB 0.0007
2822 Cholesterol oxidase choA 0.0007
2526 NADPH-ferredoxin reductase fprA fprA 0.0007
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0007
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
2893 Glycine oxidase thiO 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2769 P-hydroxybenzoate hydroxylase pobA 0.0006
2809 P-hydroxybenzoate hydroxylase pobA 0.0006
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0006
2567 Thymidylate synthase thyX thyX 0.0006
2823 Trypanothione reductase TPR 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
6645 D-amino-acid oxidase DAO 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2207 Rhodopsin RHO 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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