DT-Web: DB01175

Identification

Name

Escitalopram

Accession Number

DB01175 (APRD00683)

Type

small molecule

Description

Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D₂ or histamine H₁ receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT_1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT_1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

324.3919

Groups

approved

Monoisotopic Weight

324.163791509

Pharmacology

Indication

Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients.

Mechanism of action

The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Escitalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Absorption

The absolute bioavailability of citalopram is about 80% relative to an intravenous dose.

Protein binding

~56%

Biotransformation

Mainly hepatic. Escitalopram undergoes N-demethylation to S-demethylcitalopram (S-DCT) and S-didemethylcitalopram (S-DDCT). CYP3A4 and CYP2C19 are the enzymes responsible for this N-demethylation reaction.

Route of elimination

Following oral administrations of escitalopram, the fraction of drug recovered in the urine as escitalopram and S-demethylcitalopram (S-DCT) is about 8% and 10%, respectively. The oral clearance of escitalopram is 600 mL/min, with approximately 7% of that due to renal clearance. Escitalopram is metabolized to S-DCT and S-didemethylcitalopram (S-DDCT).

Toxicity

Signs of overdose include convulsions, coma, dizziness, hypotension, insomnia, nausea, vomiting, sinus tachycardia, somnolence, and ECG changes (including QT prolongation).

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Almotriptan	Increased risk of CNS adverse effects
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Carvedilol	The SSRI, escitalopram, may increase the bradycardic effect of the beta-blocker, carvedilol.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Eletriptan	Increased risk of CNS adverse effects
Frovatriptan	Increased risk of CNS adverse effects
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Isocarboxazid	Possible severe adverse reaction with this combination
Ketoprofen	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Linezolid	Combination associated with possible serotoninergic syndrome
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Metoprolol	The SSRI, escitalopram, may increase the bradycardic effect of the beta-blocker, metoprolol.
Naratriptan	Increased risk of CNS adverse effects
Oxycodone	Increased risk of serotonin syndrome
Phenelzine	Possible severe adverse reaction with this combination
Pimozide	The SSRI, escitalopram, increases the effect and toxicity of pimozide.
Propranolol	The SSRI, escitalopram, may increase the bradycardic effect of the beta-blocker, propranolol.
Rasagiline	Possible severe adverse reaction with this combination
Rizatriptan	Increased risk of CNS adverse effects
Selegiline	Possible severe adverse reaction with this combination
Sibutramine	Risk of serotoninergic syndrome
St. John's Wort	St. John's Wort increases the effect and toxicity of the SSRI, escitalopram.
Sumatriptan	Increased risk of CNS adverse effects
Telaprevir	Telaprevir decreases Cmax, Cmin, and AUC of escitalopram however the mechanism of this interaction is unknown. Concomitant therapy may call for dose adjustment.
Telithromycin	Telithromycin may reduce clearance of Escitalopram. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Escitalopram if Telithromycin is initiated, discontinued or dose changed.
Tiaprofenic acid	Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
Ticlopidine	Ticlopidine may decrease the metabolism and clearance of Escitalopram. Consider alternate therapy or monitor for adverse/toxic effects of Ambrisentan if Escitalopram is initiated, discontinued or dose changed.
Tolmetin	Increased antiplatelet effects may enhance the risk of bleeding. Alternate therapy may be considered or monitor for inreased bleeding during concomitant therapy.
Tramadol	Tramadol may increase the risk of serotonin syndrome and seizures.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Treprostinil	The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Escitalopram. Monitor for increased bleeding during concomitant thearpy.
Trimipramine	The SSRI, Escitalopram, may decrease the metabolism and clearance of Trimipramine. Increased risk of serotonin syndrome. Monitor for changes in Trimipramine efficacy and toxicity if Escitalopram is initiated, discontinued or dose changed.
Triprolidine	The CNS depressants, Triprolidine and Escitalopram, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of escitalopram by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of escitalopram if voriconazole is initiated, discontinued or dose changed.
Ziprasidone	Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and escitalopram, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take without regard to meals.

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Owens MJ, Knight DL, Nemeroff CB: Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry. 2001 Sep 1;50(5):345-50. - Pubmed Owens JM, Knight DL, Nemeroff CB: [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine] Encephale. 2002 Jul-Aug;28(4):350-5. - Pubmed Burke WJ: Escitalopram. Expert Opin Investig Drugs. 2002 Oct;11(10):1477-86. - Pubmed Waugh J, Goa KL: Escitalopram : a review of its use in the management of major depressive and anxiety disorders. CNS Drugs. 2003;17(5):343-62. - Pubmed Sanchez C, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O: Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl). 2003 Jun;167(4):353-62. Epub 2003 Apr 26. - Pubmed Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed Fabre V, Hamon M: [Mechanisms of action of antidepressants: new data from Escitalopram] Encephale. 2003 May-Jun;29(3 Pt 1):259-65. - Pubmed Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sanchez C: An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. Neurosci Lett. 2009 Oct 25;462(3):207-12. Epub 2009 Jul 16. - Pubmed
DTHybrid score	0.4958
Sodium-dependent dopamine transporter
Name	Sodium-dependent dopamine transporter
Gene Name	SLC6A3
Pharmacological action	unknown
Actions	inhibitor
References	Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score	0.5958
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	unknown
Actions	inhibitor
References	Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score	0.6727
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	unknown
Actions	antagonist
References	Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed Fabre V, Hamon M: [Mechanisms of action of antidepressants: new data from Escitalopram] Encephale. 2003 May-Jun;29(3 Pt 1):259-65. - Pubmed
DTHybrid score	0.4233
Muscarinic acetylcholine receptor M1
Name	Muscarinic acetylcholine receptor M1
Gene Name	CHRM1
Pharmacological action	unknown
Actions	antagonist
References	Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed
DTHybrid score	0.4941
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	unknown
Actions	antagonist
References	Bareggi SR, Mundo E, Dell'Osso B, Altamura AC: The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):741-53. - Pubmed Fabre V, Hamon M: [Mechanisms of action of antidepressants: new data from Escitalopram] Encephale. 2003 May-Jun;29(3 Pt 1):259-65. - Pubmed
DTHybrid score	0.6436

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5832
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3484
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.636

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.258
1588	Multidrug resistance protein 1	ABCB1	0.2381
4200	Cytochrome P450 1A2	CYP1A2	0.2337
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1985
51	Muscarinic acetylcholine receptor M3	CHRM3	0.1863
318	Alpha-2A adrenergic receptor	ADRA2A	0.1774
632	Alpha-1B adrenergic receptor	ADRA1B	0.1645
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1638
6030	Cytochrome P450 2B6	CYP2B6	0.1601
4118	Cytochrome P450 3A5	CYP3A5	0.158
4924	Cytochrome P450 2C8	CYP2C8	0.143
6013	Cytochrome P450 2E1	CYP2E1	0.1266
450	Muscarinic acetylcholine receptor M4	CHRM4	0.1266
274	Muscarinic acetylcholine receptor M5	CHRM5	0.1167
831	D(2) dopamine receptor	DRD2	0.1164
131	Synaptic vesicular amine transporter	SLC18A2	0.1163
6107	Cytochrome P450 3A7	CYP3A7	0.1154
590	5-hydroxytryptamine 2C receptor	HTR2C	0.1113
3941	Amine oxidase [flavin-containing] A	MAOA	0.1056
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0935
23	D(1A) dopamine receptor	DRD1	0.0887
789	Alpha-1D adrenergic receptor	ADRA1D	0.0853
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0848
3939	Amine oxidase [flavin-containing] B	MAOB	0.0798
766	Beta-2 adrenergic receptor	ADRB2	0.0724
629	Alpha-2B adrenergic receptor	ADRA2B	0.0692
5718	Cytochrome P450 2A6	CYP2A6	0.0683
6024	Cytochrome P450 1A1	CYP1A1	0.0664
193	Beta-1 adrenergic receptor	ADRB1	0.0662
378	Alpha-2C adrenergic receptor	ADRA2C	0.0587
587	Serum albumin	ALB	0.0583
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0555
6145	Solute carrier family 22 member 1	SLC22A1	0.0545
6144	Solute carrier family 22 member 2	SLC22A2	0.053
3923	Cholinesterase	BCHE	0.0516
118	Organic cation/carnitine transporter 2	SLC22A5	0.0452
6106	Cytochrome P450 2C18	CYP2C18	0.0445
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0435
1656	CYP2B protein	CYP2B	0.0434
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0427
432	D(4) dopamine receptor	DRD4	0.0402
20	Prostaglandin G/H synthase 1	PTGS1	0.04
638	D(3) dopamine receptor	DRD3	0.0386
1636	Trace amine-associated receptor 1	TAAR1	0.0384
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0369
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0365
6147	Solute carrier family 22 member 3	SLC22A3	0.0356
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0339
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0338
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0315
124	Histamine H2 receptor	HRH2	0.0313
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0307
847	Mu-type opioid receptor	OPRM1	0.0297
467	Delta-type opioid receptor	OPRD1	0.0295
696	Kappa-type opioid receptor	OPRK1	0.0294
833	Organic cation/carnitine transporter 1	SLC22A4	0.0279
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0277
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0273
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0273
716	5-hydroxytryptamine 7 receptor	HTR7	0.026
163	D(1B) dopamine receptor	DRD5	0.0245
1729	Solute carrier family 22 member 6	SLC22A6	0.0243
6182	Cytochrome P450 2J2	CYP2J2	0.0237
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0229
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0225
3811	Cytochrome P450 19A1	CYP19A1	0.0225
465	Calmodulin	CALM1	0.0217
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0209
731	HIV-1 protease	HIV-1 protease	0.0208
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0208
862	Multidrug resistance-associated protein 1	ABCC1	0.0206
474	Acetylcholinesterase	ACHE	0.0203
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0202
6432	Transporter	snf	0.02
1517	Beta-3 adrenergic receptor	ADRB3	0.02
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0195
871	Glucocorticoid receptor	NR3C1	0.0195
1341	Histamine H3 receptor	HRH3	0.0189
1898	Cytochrome P450 1B1	CYP1B1	0.0177
260	Cytochrome P450 51	ERG11	0.0171
761	Cytochrome P450 51	ERG11	0.0171
3163	Cytochrome P450 51	cyp51	0.0171
516	Neurotensin receptor type 2	NTSR2	0.0168
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0157
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0156
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0156
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0155
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0155
776	Bile salt export pump	ABCB11	0.0154
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0154
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0152
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0145
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0143
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0143
290	Prostaglandin G/H synthase 2	PTGS2	0.0141
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0141
4120	NADPH--cytochrome P450 reductase	POR	0.0137
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0137
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0134
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0134
1757	Myeloperoxidase	MPO	0.0133
136	Estrogen receptor	ESR1	0.0132
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.013
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0129
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0129
94	5-hydroxytryptamine 4 receptor	HTR4	0.0123
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0121
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.012
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.012
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0116
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0114
6142	Solute carrier family 22 member 8	SLC22A8	0.0113
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0111
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.011
6031	Cytochrome P450 3A43	CYP3A43	0.011
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0107
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0107
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0107
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0101
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0101
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0101
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.01
380	Cytochrome P450 17A1	CYP17A1	0.0099
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0099
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0098
817	DNA topoisomerase 2-alpha	TOP2A	0.0098
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0098
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0098
146	Androgen receptor	AR	0.0096
468	Cytochrome P450 4A11	CYP4A11	0.0095
1275	Estrogen sulfotransferase	SULT1E1	0.0093
828	Phenylalanine-4-hydroxylase	PAH	0.0093
3109	Phenylalanine-4-hydroxylase	phhA	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
2164	Multidrug resistance-associated protein 4	ABCC4	0.0092
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0091
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0088
6143	Solute carrier family 22 member 7	SLC22A7	0.0088
614	Progesterone receptor	PGR	0.0086
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0086
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0086
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0086
723	Cytosolic phospholipase A2	PLA2G4A	0.0085
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0084
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0081
122	P2Y purinoceptor 12	P2RY12	0.0081
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.008
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0079
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0079
161	Tubulin beta chain	TUBB	0.0079
312	Tubulin beta chain	TUB2	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1618	High affinity nerve growth factor receptor	NTRK1	0.0077
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0074
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0074
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0074
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0071
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0071
818	50S ribosomal protein L10	rplJ	0.0071
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0071
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.007
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0069
3947	Xanthine dehydrogenase/oxidase	XDH	0.0069
164	Histamine H4 receptor	HRH4	0.0067
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0066
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0066
482	Glycine receptor subunit alpha-1	GLRA1	0.0066
904	Glutathione S-transferase P	GSTP1	0.0065
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0065
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0065
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0065
844	Epidermal growth factor receptor	EGFR	0.0064
952	Dipeptidyl peptidase 4	DPP4	0.0064
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0063
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0062
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0062
592	Carbonic anhydrase 4	CA4	0.0062
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0061
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0061
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0061
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0061
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.006
6148	Multidrug resistance-associated protein 7	ABCC10	0.006
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0059
777	Tumor necrosis factor	TNF	0.0059
6138	Multidrug resistance protein 3	ABCB4	0.0058
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0058
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0058
6220	Aryl hydrocarbon receptor	AHR	0.0057
174	Sigma 1-type opioid receptor	SIGMAR1	0.0057
504	Mast/stem cell growth factor receptor	KIT	0.0057
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0057
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0056
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0056
3426	Glutamine synthetase	glnA	0.0056
3987	Glutamine synthetase	GLUL	0.0056
6506	Stathmin-4	STMN4	0.0055
373	Transthyretin	TTR	0.0054
4604	Liver carboxylesterase 1	CES1	0.0054
891	Dihydropteroate synthase	folP	0.0054
5359	Dihydropteroate synthase	folP	0.0054
7175	Dihydropteroate synthase	sulI	0.0054
407	Vascular endothelial growth factor receptor 2	KDR	0.0052
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0052
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0052
49	Endothelin B receptor	EDNRB	0.0052
70	Type-1 angiotensin II receptor	AGTR1	0.0052
1048	Protein S100-A13	S100A13	0.0052
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0052
2226	Protein S100-A12	S100A12	0.0052
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0052
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0052
183	Vascular endothelial growth factor A	VEGFA	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
319	Opioid receptor, sigma 1	OPRS1	0.0051
6014	Cytochrome P450 2A13	CYP2A13	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
1024	Solute carrier family 22 member 11	SLC22A11	0.005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.005
26	Vascular endothelial growth factor receptor 3	FLT4	0.0049
6137	Multidrug resistance-associated protein 6	ABCC6	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
4203	Histamine N-methyltransferase	HNMT	0.0049
2132	Protein S100-B	S100B	0.0049
173	Toll-like receptor 7	TLR7	0.0049
68	Cannabinoid receptor 1	CNR1	0.0048
32	Vascular endothelial growth factor receptor 1	FLT1	0.0047
856	Vitamin D3 receptor	VDR	0.0047
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0047
811	Translocator protein	TSPO	0.0047
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0047
6102	Arylamine N-acetyltransferase 2	NAT2	0.0047
756	Sex hormone-binding globulin	SHBG	0.0046
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0046
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0046
295	Carbonic anhydrase 1	CA1	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
357	Carbonic anhydrase 2	CA2	0.0046
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0045
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0045
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
153	Dopamine beta-hydroxylase	DBH	0.0044
571	Melatonin receptor type 1A	MTNR1A	0.0044
362	Melatonin receptor type 1B	MTNR1B	0.0044
1010	Cytochrome P450 51A1	CYP51A1	0.0044
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0043
2129	Sucrase-isomaltase, intestinal	SI	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0042
6136	Multidrug resistance-associated protein 5	ABCC5	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0041
365	Dihydrofolate reductase	DHFR	0.0041
2381	Dihydrofolate reductase	DFR1	0.0041
2833	Dihydrofolate reductase	Not Available	0.0041
2931	Dihydrofolate reductase	folA	0.0041
3544	Dihydrofolate reductase	folA	0.0041
3682	Dihydrofolate reductase	folA	0.0041
6642	Dihydrofolate reductase	folA	0.0041
6756	Dihydrofolate reductase	dfrA	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.004
29	Tubulin beta-1 chain	TUBB1	0.004
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0039
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0038
85	Growth hormone receptor	GHR	0.0038
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0037
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0037
233	Potassium channel subfamily K member 2	KCNK2	0.0037
6141	Sodium/bile acid cotransporter	SLC10A1	0.0037
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0037
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0036
6020	Aldehyde oxidase	AOX1	0.0036
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6151	Monocarboxylate transporter 10	SLC16A10	0.0035
921	Glutamate receptor 2	GRIA2	0.0035
6859	Protein S100-A4	S100A4	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
6043	Putative G-protein coupled receptor 44	GPR44	0.0034
6126	Carbonic anhydrase 7	CA7	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0033
3810	Catechol O-methyltransferase	COMT	0.0033
284	DNA-directed RNA polymerase beta chain	rpoB	0.0033
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0033
737	Mineralocorticoid receptor	NR3C2	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
427	Substance-P receptor	TACR1	0.0033
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0032
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0032
581	Cytochrome P450 2R1	CYP2R1	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.0031
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0031
869	Estrogen receptor beta	ESR2	0.0031
1629	Transcription factor AP-1	JUN	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
4311	tRNA	TRDMT1	0.003
4325	tRNA	trmD	0.003
4328	tRNA	trmD	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.003
705	Glutamate receptor 1	GRIA1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
518	Peroxidase/catalase T	katG	0.003
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0029
1178	Adenosine A2a receptor	ADORA2A	0.0029
1374	Natriuretic peptides B	NPPB	0.0029
1827	Gap junction alpha-1 protein	GJA1	0.0029
1908	Vascular cell adhesion protein 1	VCAM1	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0029
4122	Histone deacetylase 2	HDAC2	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0028
563	Thyroid peroxidase	TPO	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
738	Monocarboxylate transporter 1	SLC16A1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0026
634	Squalene monooxygenase	SQLE	0.0026
7196	Squalene monooxygenase	ERG1	0.0026
823	Fibroblast growth factor receptor 2	FGFR2	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0025
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0025
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0024
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0023
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
165	FL cytokine receptor	FLT3	0.0022
3404	Exotoxin A	eta	0.0022
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
298	Renin	REN	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0021
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0021
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0021
16	Adenosine A1 receptor	ADORA1	0.0021
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1992	Vitamin D-binding protein	GC	0.002
5787	Angiopoietin-1 receptor	TEK	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.002
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
106	Cannabinoid receptor 2	CNR2	0.002
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.002
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
6174	50S ribosomal protein L32	rpmF	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
239	Coagulation factor X	F10	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
976	Platelet glycoprotein IX	GP9	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
1630	Integrin beta-2	ITGB2	0.0019
4103	Proteasome subunit beta type 2	PSMB2	0.0019
4102	Proteasome subunit beta type 5	PSMB5	0.0019
4101	Proteasome subunit beta type 1	PSMB1	0.0019
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
558	Solute carrier family 12 member 1	SLC12A1	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
1192	Sulfotransferase 1A1	SULT1A1	0.0018
275	Arachidonate 5-lipoxygenase	ALOX5	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
6146	High affinity copper uptake protein 1	SLC31A1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
7	Nitric oxide synthase, inducible	NOS2	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
4773	Deoxycytidine kinase	DCK	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0016
3233	Bile acid receptor	NR1H4	0.0015
3937	Fatty-acid amide hydrolase	FAAH	0.0015
6044	Serum paraoxonase/lactonase 3	PON3	0.0015
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0015
3601	Dihydropteroate synthase 1	folP1	0.0015
3807	Dihydropteroate synthase 1	folP1	0.0015
3808	Dihydropteroate synthase 2	folP2	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0015
469	Annexin A1	ANXA1	0.0015
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0015
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
1541	Metalloproteinase	mmp20	0.0014
572	Integrin alpha-L	ITGAL	0.0014
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0014
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1864	RET proto-oncogene	RET	0.0014
6085	Fatty acid-binding protein, intestinal	FABP2	0.0014
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0014
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0014
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
84	Nuclear receptor 0B1	NR0B1	0.0014
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0013
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0013
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0013
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0013
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0013
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
5934	Cytochrome P450 26A1	CYP26A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
4217	Telomerase reverse transcriptase	TERT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
251	Alcohol dehydrogenase 1A	ADH1A	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
273	Apoptosis regulator Bcl-2	BCL2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
936	Ephrin type-A receptor 2	EPHA2	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
3809	Estrogen-related receptor gamma	ESRRG	0.0011
820	Glycine receptor subunit alpha-2	GLRA2	0.0011
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.001
54	Prothrombin	F2	0.001
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
291	Nitric-oxide synthase, endothelial	NOS3	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.001
33	Cystine/glutamate transporter	SLC7A11	0.001
444	Alcohol dehydrogenase 1B	ADH1B	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5798	Mitogen-activated protein kinase 11	MAPK11	0.0009
2320	Thymidine kinase, cytosolic	TK1	0.0009
267	Plasminogen activator inhibitor 1	SERPINE1	0.0009
3830	Calreticulin	CALR	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
6149	Solute carrier family 22 member 10	SLC22A10	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
517	Alcohol dehydrogenase 1C	ADH1C	0.0009
6218	Pannexin-1	PANX1	0.0008
6221	Steroid hormone receptor ERR1	ESRRA	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2021	Thrombomodulin	THBD	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
751	Potassium channel subfamily K member 6	KCNK6	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
172	Potassium channel subfamily K member 1	KCNK1	0.0006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
3957	Adenosine deaminase	ADA	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
2207	Rhodopsin	RHO	0.0005
6042	Prostaglandin reductase 2	PTGR2	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
1792	Tissue-type plasminogen activator	PLAT	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
1313	Lactoylglutathione lyase	GLO1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
908	Glutathione S-transferase theta-1	GSTT1	0.0003
162	Retinoic acid receptor gamma-1	RARG	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01175 - Escitalopram

Targets

Enzymes

Predictions