DT-Web: DB01009

Identification

Name

Ketoprofen

Accession Number

DB01009 (APRD01059, DB05823)

Type

small molecule

Description

Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

254.2806

Groups

approved

Monoisotopic Weight

254.094294314

Pharmacology

Indication

For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.

Mechanism of action

The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Absorption

Ketoprofen is rapidly and well-absorbed orally, with peak plasma levels occurring within 0.5 to 2 hours.

Protein binding

99% bound, primarily to albumin

Biotransformation

Rapidly and extensively metabolized in the liver, primarily via conjugation to glucuronic acid. No active metabolites have been identified.

Route of elimination

In a 24 hour period, approximately 80% of an administered dose of ketoprofen is excreted in the urine, primarily as the glucuronide metabolite.

Toxicity

LD₅₀=62.4 mg/kg (rat, oral).

Symptoms of overdose include drowsiness, vomiting and abdominal pain.

Side effects are usually mild and mainly involved the GI tract. Most common adverse GI effect is dyspepsia (11% of patients). May cause nausea, diarrhea, abdominal pain, constipation and flatulence in greater than 3% of patients.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The NSAID, ketoprofen, may increase the anticoagulant effect of acenocoumarol.
Acetylsalicylic acid	Concomitant therapy of the NSAID, ketoprofen, and acetylsalicylic acid may result in additive adverse/toxic effects (e.g. GI bleeding). The NSAID may also limit the cardioprotective effect of acetylsalicylic acid. Occasional concomitant use may not cause clinically significant problems, but regular, frequent concomitant therapy is not recommended.
Anisindione	The NSAID, ketoprofen, may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Citalopram	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Colesevelam	Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine	The NSAID, ketoprofen, may increase the serum concentration of cyclosporine. Ketoprofen may also increase the nephrotoxicity of cyclosporine.
Dicumarol	The NSAID, ketoprofen, may increase the anticoagulant effect of dicumarol.
Drotrecogin alfa	The antiplatelet effect of ketoprofen may increase the bleed risk associated with drotrecogin alfa. Consider spacing use of the two agents by at least 7 days. Increase monitoring for signs and symptoms of bleeding during concomitant therapy.
Eltrombopag	Increases levels of Ketoprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Escitalopram	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Fluoxetine	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Fluvoxamine	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Ginkgo biloba	Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Ginseng	Increased risk of bleeding due to additive anticoagulant properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Ketorolac	Concomitant use of ketoprofen and ketorolac, two NSAIDs, is contraindicated due to the risk of additive or synergistic NSAID toxicities (e.g. GI bleeding, ulceration, renal dysfunction, etc).
Lithium	The NSAID, ketoprofen, may increase the serum concentration of lithium by decreasing its renal clearance. Consider a dose reduction in lithium upon initiation of ketoprofen therapy. Monitor for changes in the therapeutic and adverse effects of lithium if ketoprofen is initiated, discontinued or does changed.
Methotrexate	The NSAID, ketoprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Paroxetine	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Pemetrexed	The NSAID, ketoprofen, may increase increase the serum concentration of pemetrexed by decreasing its renal clearance. Patients with mild to moderate renal insufficiency (CrCl 45-79 ml/min) should avoid use of ketoprofen within 2 days of a pemetrexed dose. Patients with better renal function do not appear to be at risk. Monitor for toxicity in all patients during concomitant therapy.
S-Adenosylmethionine	Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Sertraline	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Telmisartan	Concomitant use of Telmisartan and Ketoprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	The NSAID, Ketoprofen, may antagonize the antihypertensive effect of Timolol.
Trandolapril	The NSAID, Ketoprofen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Ketoprofen is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Ketoprofen. Monitor for increased bleeding during concomitant thearpy.
Warfarin	The antiplatelet effects of ketoprofen may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.

Food Interactions

Food prolongs rate of absorption and decreases peak plasma concentration. Extent of absorption is not affected.
Avoid alcohol.
Take with food to reduce gastric irritation.

Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	unknown
Actions	inhibitor
References	Parsadaniantz SM, Lebeau A, Duval P, Grimaldi B, Terlain B, Kerdelhue B: Effects of the inhibition of cyclo-oxygenase 1 or 2 or 5-lipoxygenase on the activation of the hypothalamic-pituitary-adrenal axis induced by interleukin-1beta in the male Rat. J Neuroendocrinol. 2000 Aug;12(8):766-73. - Pubmed Kurahashi K, Shirahase H, Nakamura S, Tarumi T, Koshino Y, Wang AM, Nishihashi T, Shimizu Y: Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites. J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S21-5. - Pubmed Zuniga J, Fuenzalida M, Guerrero A, Illanes J, Dabancens A, Diaz E, Lemus D: Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo. Biol Res. 2003;36(2):233-40. - Pubmed Martic M, Tatic I, Markovic S, Kujundzic N, Kostrun S: Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors. Eur J Med Chem. 2004 Feb;39(2):141-51. - Pubmed Levoin N, Blondeau C, Guillaume C, Grandcolas L, Chretien F, Jouzeau JY, Benoit E, Chapleur Y, Netter P, Lapicque F: Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronic conjugates of ketoprofen. Biochem Pharmacol. 2004 Nov 15;68(10):1957-69. - Pubmed
DTHybrid score	0.7354
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Kay-Mugford P, Benn SJ, LaMarre J, Conlon P: In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Am J Vet Res. 2000 Jul;61(7):802-10. - Pubmed Sommerauer M, Ates M, Guhring H, Brune K, Amann R, Peskar BA: Ketoprofen-induced cyclooxygenase inhibition in renal medulla and platelets of rats treated with caffeine. Pharmacology. 2001;63(4):234-9. - Pubmed Levoin N, Chretien F, Lapicque F, Chapleur Y: Synthesis and biological testing of Acyl-CoA-ketoprofen conjugates as selective irreversible inhibitors of COX-2. Bioorg Med Chem. 2002 Mar;10(3):753-7. - Pubmed Zuniga J, Fuenzalida M, Guerrero A, Illanes J, Dabancens A, Diaz E, Lemus D: Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo. Biol Res. 2003;36(2):233-40. - Pubmed Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6755
High affinity interleukin-8 receptor A
Name	High affinity interleukin-8 receptor A
Gene Name	CXCR1
Pharmacological action	unknown
Actions	other
References	Allegretti M, Bertini R, Cesta MC, Bizzarri C, Di Bitondo R, Di Cioccio V, Galliera E, Berdini V, Topai A, Zampella G, Russo V, Di Bello N, Nano G, Nicolini L, Locati M, Fantucci P, Florio S, Colotta F: 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. - Pubmed Bizzarri C, Pagliei S, Brandolini L, Mascagni P, Caselli G, Transidico P, Sozzani S, Bertini R: Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers. Biochem Pharmacol. 2001 Jun 1;61(11):1429-37. - Pubmed Wang LM, Toyoshima A, Mineshita S, Wang XX, Yamamoto T, Nomura Y, Yang L, Koikei Y, Shiba K, Honda Y: The anti-inflammatory effects of ketoprofen in animal experiments. Drugs Exp Clin Res. 1997;23(1):1-6. - Pubmed
DTHybrid score	0.2004

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5317
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3866

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score	0.2916
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score	0.314
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. - Pubmed Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. - Pubmed Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score	0.6174
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed
DTHybrid score	0.5078
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
DTHybrid score	0.3915
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y: Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84. - Pubmed Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
DTHybrid score	0.343

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.2916
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.314
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.6174
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.5078
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.3915
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.343

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.3317
6016	Cytochrome P450 2C19	CYP2C19	0.2429
1588	Multidrug resistance protein 1	ABCB1	0.2316
4200	Cytochrome P450 1A2	CYP1A2	0.191
4119	Cytochrome P450 2D6	CYP2D6	0.1621
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1348
4118	Cytochrome P450 3A5	CYP3A5	0.1345
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1246
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1096
6030	Cytochrome P450 2B6	CYP2B6	0.1053
6013	Cytochrome P450 2E1	CYP2E1	0.1023
862	Multidrug resistance-associated protein 1	ABCC1	0.0982
6107	Cytochrome P450 3A7	CYP3A7	0.098
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0907
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0889
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0875
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0806
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0804
6136	Multidrug resistance-associated protein 5	ABCC5	0.0776
118	Organic cation/carnitine transporter 2	SLC22A5	0.0773
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0772
6141	Sodium/bile acid cotransporter	SLC10A1	0.077
6024	Cytochrome P450 1A1	CYP1A1	0.0761
6145	Solute carrier family 22 member 1	SLC22A1	0.0749
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0746
776	Bile salt export pump	ABCB11	0.0719
5718	Cytochrome P450 2A6	CYP2A6	0.0702
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0669
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0665
275	Arachidonate 5-lipoxygenase	ALOX5	0.0643
738	Monocarboxylate transporter 1	SLC16A1	0.0622
6144	Solute carrier family 22 member 2	SLC22A2	0.062
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0591
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0589
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0527
6106	Cytochrome P450 2C18	CYP2C18	0.0526
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0524
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.05
22	30S ribosomal protein S4	rpsD	0.0462
6714	30S ribosomal protein S4	rpsD	0.0462
140	30S ribosomal protein S9	rpsI	0.0435
6719	30S ribosomal protein S9	rpsI	0.0435
6725	30S ribosomal protein S9	rpsI	0.0435
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0426
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0421
1757	Myeloperoxidase	MPO	0.0396
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0388
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0369
645	Penicillin-binding protein 1A	mrcA	0.0366
5805	Penicillin-binding protein 1A	ponA	0.0366
6185	Penicillin-binding protein 1A	mrcA	0.0366
6799	Penicillin-binding protein 1A	pbpA	0.0366
373	Transthyretin	TTR	0.0362
891	Dihydropteroate synthase	folP	0.0359
5359	Dihydropteroate synthase	folP	0.0359
7175	Dihydropteroate synthase	sulI	0.0359
833	Organic cation/carnitine transporter 1	SLC22A4	0.0357
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0357
6149	Solute carrier family 22 member 10	SLC22A10	0.035
543	Penicillin-binding protein 1B	mrcB	0.0347
6186	Penicillin-binding protein 1B	ponB	0.0347
6822	Penicillin-binding protein 1b	pbp1b	0.0347
6844	Penicillin-binding protein 1b	pbp1b	0.0347
558	Solute carrier family 12 member 1	SLC12A1	0.0346
6148	Multidrug resistance-associated protein 7	ABCC10	0.0342
1898	Cytochrome P450 1B1	CYP1B1	0.0328
3811	Cytochrome P450 19A1	CYP19A1	0.0327
633	Penicillin-binding proteins 1A/1B	pbpA	0.0324
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0324
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0319
146	Androgen receptor	AR	0.0314
136	Estrogen receptor	ESR1	0.031
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0295
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0292
6147	Solute carrier family 22 member 3	SLC22A3	0.029
338	DNA polymerase	UL30	0.0285
379	DNA polymerase	UL54	0.0285
697	DNA polymerase	ORF28	0.0285
2482	DNA polymerase	43	0.0285
4104	DNA polymerase	BALF5	0.0285
33	Cystine/glutamate transporter	SLC7A11	0.0283
672	Prostaglandin F2-alpha receptor	PTGFR	0.0283
6085	Fatty acid-binding protein, intestinal	FABP2	0.0282
3947	Xanthine dehydrogenase/oxidase	XDH	0.0279
6020	Aldehyde oxidase	AOX1	0.0276
4604	Liver carboxylesterase 1	CES1	0.027
5353	Glutamate decarboxylase alpha	gadA	0.027
24	Thymidylate synthase	TMP1	0.0268
359	Thymidylate synthase	TYMS	0.0268
2626	Thymidylate synthase	thyA	0.0268
2729	Thymidylate synthase	thyA	0.0268
5352	Thymidylate synthase	THYA	0.0268
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0266
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0266
5626	Nucleoside diphosphate kinase B	NME2	0.0266
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0262
6137	Multidrug resistance-associated protein 6	ABCC6	0.0258
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0258
1	Peptidoglycan synthetase ftsI	ftsI	0.0254
4155	Peptidoglycan synthetase ftsI	ftsI	0.0254
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0251
438	Taste receptor type 1 member 2	TAS1R2	0.0248
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0243
6167	Organic solute transporter subunit beta	OSTB	0.0242
6166	Organic solute transporter subunit alpha	OSTA	0.0242
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0242
115	Penicillin-binding protein 2	mrdA	0.024
6069	Penicillin-binding protein 2	mrdA	0.024
6118	Penicillin-binding protein 2	penA	0.024
6187	Penicillin-binding protein 2	pbpA	0.024
6686	Penicillin-binding protein 2	pbp2	0.024
6939	Penicillin-binding protein 2	mrdA	0.024
7163	Penicillin-binding protein 2	pbpA	0.024
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0238
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0238
492	Histamine H1 receptor	HRH1	0.0234
756	Sex hormone-binding globulin	SHBG	0.0233
1867	Major prion protein	PRNP	0.0232
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.023
244	Angiotensin-converting enzyme	ACE	0.0227
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0227
130	Prostacyclin synthase	PTGIS	0.0226
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0225
1507	Cytochrome c	CYCS	0.0224
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0223
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
3312	Fatty acid-binding protein, brain	FABP7	0.0217
5294	Nucleoside diphosphate kinase A	NME1	0.0214
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0213
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0213
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0211
6043	Putative G-protein coupled receptor 44	GPR44	0.0209
3923	Cholinesterase	BCHE	0.0206
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0205
357	Carbonic anhydrase 2	CA2	0.0205
887	DNA gyrase subunit B	gyrB	0.0201
4150	DNA gyrase subunit B	gyrB	0.0201
6225	DNA gyrase subunit B	gyrB	0.0201
6207	30S ribosomal protein S14	rpsN	0.02
6209	30S ribosomal protein S19	rpsS	0.02
6712	30S ribosomal protein S19	rpsS	0.02
6726	30S ribosomal protein S19	rpsS	0.02
6031	Cytochrome P450 3A43	CYP3A43	0.0199
70	Type-1 angiotensin II receptor	AGTR1	0.0198
183	Vascular endothelial growth factor A	VEGFA	0.0198
527	Prostacyclin receptor	PTGIR	0.0197
2016	Dipeptidase 1	DPEP1	0.0197
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0197
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0196
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0196
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0196
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0196
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0195
592	Carbonic anhydrase 4	CA4	0.0194
3587	Gastrotropin	FABP6	0.0192
295	Carbonic anhydrase 1	CA1	0.0191
1648	Elastin	ELN	0.0191
3685	Catabolite gene activator	crp	0.0189
4655	Adenylate cyclase	cyaC	0.0189
4759	Adenylate cyclase	cyaB2	0.0189
871	Glucocorticoid receptor	NR3C1	0.0188
1405	Thiopurine S-methyltransferase	TPMT	0.0187
1159	Interleukin-6	IL6	0.0185
3639	Thymidine phosphorylase	deoA	0.0183
3936	Thymidine phosphorylase	TYMP	0.0183
663	Solute carrier family 12 member 4	SLC12A4	0.0182
53	Solute carrier family 12 member 5	SLC12A5	0.0182
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0178
1650	Heme carrier protein 1	SLC46A1	0.0178
6102	Arylamine N-acetyltransferase 2	NAT2	0.0174
2320	Thymidine kinase, cytosolic	TK1	0.0173
310	Solute carrier family 12 member 2	SLC12A2	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0169
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0169
904	Glutathione S-transferase P	GSTP1	0.0168
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0168
2249	Aspartate aminotransferase	aspC	0.0167
2671	Aspartate aminotransferase	aspC	0.0167
5490	Aspartate aminotransferase	Not Available	0.0167
1198	Serum paraoxonase/arylesterase 1	PON1	0.0167
723	Cytosolic phospholipase A2	PLA2G4A	0.0167
6223	Penicillin-binding protein 1C	pbpC	0.0167
4217	Telomerase reverse transcriptase	TERT	0.0161
4760	Mll3241 protein	mll3241	0.0161
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0158
824	Sodium-dependent serotonin transporter	SLC6A4	0.0154
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0154
6220	Aryl hydrocarbon receptor	AHR	0.0152
737	Mineralocorticoid receptor	NR3C2	0.0152
2021	Thrombomodulin	THBD	0.0152
731	HIV-1 protease	HIV-1 protease	0.0151
293	Gamma-glutamyl hydrolase	GGH	0.015
777	Tumor necrosis factor	TNF	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0149
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0148
3941	Amine oxidase [flavin-containing] A	MAOA	0.0147
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0146
869	Estrogen receptor beta	ESR2	0.0146
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0145
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0144
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0144
594	Thyroxine-binding globulin	SERPINA7	0.0144
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0143
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
696	Kappa-type opioid receptor	OPRK1	0.0142
273	Apoptosis regulator Bcl-2	BCL2	0.0141
831	D(2) dopamine receptor	DRD2	0.014
867	Penicillin-binding protein 3	pbpC	0.014
6119	Penicillin-binding protein 3	pbp3	0.014
7154	Penicillin-binding protein 3	pbp3	0.014
7157	Penicillin-binding protein 3	LMHCC_2184	0.014
7162	Penicillin-binding protein 3	pbpB	0.014
7172	Penicillin-binding protein 3	pbp3	0.014
404	DNA gyrase subunit A	gyrA	0.0139
6224	DNA gyrase subunit A	gyrA	0.0139
489	Monocarboxylate transporter 2	SLC16A7	0.0139
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0138
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0138
124	Histamine H2 receptor	HRH2	0.0137
1654	Interleukin-1 beta	IL1B	0.0137
380	Cytochrome P450 17A1	CYP17A1	0.0137
468	Cytochrome P450 4A11	CYP4A11	0.0136
847	Mu-type opioid receptor	OPRM1	0.0136
758	Thyroid hormone receptor alpha	THRA	0.0133
703	NADPH azoreductase	azr	0.0132
3760	Penicillin-binding protein 5 precursor	dacA	0.0131
65	Matrix metalloproteinase-9	Not Available	0.0131
811	Translocator protein	TSPO	0.013
467	Delta-type opioid receptor	OPRD1	0.0129
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
6126	Carbonic anhydrase 7	CA7	0.0129
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0129
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0127
4122	Histone deacetylase 2	HDAC2	0.0127
6042	Prostaglandin reductase 2	PTGR2	0.0126
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0126
819	Penicillin-binding protein 4	dacB	0.0125
122	P2Y purinoceptor 12	P2RY12	0.0124
6218	Pannexin-1	PANX1	0.0124
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0124
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0124
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0123
850	Vasopressin V1b receptor	AVPR1B	0.0122
3426	Glutamine synthetase	glnA	0.0122
3987	Glutamine synthetase	GLUL	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
365	Dihydrofolate reductase	DHFR	0.012
2381	Dihydrofolate reductase	DFR1	0.012
2833	Dihydrofolate reductase	Not Available	0.012
2931	Dihydrofolate reductase	folA	0.012
3544	Dihydrofolate reductase	folA	0.012
3682	Dihydrofolate reductase	folA	0.012
6642	Dihydrofolate reductase	folA	0.012
6756	Dihydrofolate reductase	dfrA	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
346	Thyroid hormone receptor beta-1	THRB	0.0118
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0117
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0113
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0112
494	Caspase-1	CASP1	0.0111
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0111
459	Retinoic acid receptor RXR-alpha	RXRA	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
6014	Cytochrome P450 2A13	CYP2A13	0.0109
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0109
504	Mast/stem cell growth factor receptor	KIT	0.0109
2211	Fatty acid-binding protein, heart	FABP3	0.0108
185	Vasopressin V1a receptor	AVPR1A	0.0107
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0106
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
1313	Lactoylglutathione lyase	GLO1	0.0105
3810	Catechol O-methyltransferase	COMT	0.0105
322	Vasopressin V2 receptor	AVPR2	0.0105
1792	Tissue-type plasminogen activator	PLAT	0.0105
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0103
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0103
16	Adenosine A1 receptor	ADORA1	0.0103
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0103
23	D(1A) dopamine receptor	DRD1	0.0102
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0102
1178	Adenosine A2a receptor	ADORA2A	0.0102
5818	Folate receptor alpha	FOLR1	0.0102
5482	Sialidase-2	NEU2	0.0101
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.01
556	Alpha-1A adrenergic receptor	ADRA1A	0.01
1439	Lactotransferrin	LTF	0.0098
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0097
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
6500	Phospholipase A2	PLA2G1B	0.0095
566	Serotransferrin	TF	0.0094
4773	Deoxycytidine kinase	DCK	0.0094
4226	Uridine phosphorylase 2	UPP2	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
2077	Caspase-3	CASP3	0.0093
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0093
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0093
817	DNA topoisomerase 2-alpha	TOP2A	0.0092
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0092
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0092
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0091
260	Cytochrome P450 51	ERG11	0.0091
761	Cytochrome P450 51	ERG11	0.0091
3163	Cytochrome P450 51	cyp51	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
228	Beta platelet-derived growth factor receptor	PDGFRB	0.009
614	Progesterone receptor	PGR	0.0089
4116	Dihydropteroate synthetase	Not Available	0.0087
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0087
1714	Mitogen-activated protein kinase 3	MAPK3	0.0087
844	Epidermal growth factor receptor	EGFR	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
4238	50S ribosomal protein L4	rplD	0.0086
5578	50S ribosomal protein L4	rplD	0.0086
6173	50S ribosomal protein L4	rplD	0.0086
6219	50S ribosomal protein L4	rplD	0.0086
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0086
4225	Uridine phosphorylase 1	UPP1	0.0085
465	Calmodulin	CALM1	0.0085
482	Glycine receptor subunit alpha-1	GLRA1	0.0085
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0084
632	Alpha-1B adrenergic receptor	ADRA1B	0.0084
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0084
3932	Glutathione S-transferase A2	GSTA2	0.0084
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0083
1050	Bile salt sulfotransferase	SULT2A1	0.0082
199	Monocarboxylate transporter 8	SLC16A2	0.0082
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0082
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
6131	Carbonic anhydrase 14	CA14	0.0081
413	Amidophosphoribosyltransferase	PPAT	0.0081
2515	Amidophosphoribosyltransferase	purF	0.0081
3714	Amidophosphoribosyltransferase	purF	0.0081
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0081
6103	Arylamine N-acetyltransferase 1	NAT1	0.008
407	Vascular endothelial growth factor receptor 2	KDR	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
952	Dipeptidyl peptidase 4	DPP4	0.0079
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0079
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
4237	50S ribosomal protein L22	rplV	0.0079
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0079
232	Corticosteroid-binding globulin	SERPINA6	0.0079
1275	Estrogen sulfotransferase	SULT1E1	0.0078
26	Vascular endothelial growth factor receptor 3	FLT4	0.0078
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0078
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0078
634	Squalene monooxygenase	SQLE	0.0078
7196	Squalene monooxygenase	ERG1	0.0078
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0078
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0076
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0076
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0076
4221	Vascular endothelial growth factor	VEGF	0.0075
5816	Cadherin-5	CDH5	0.0075
32	Vascular endothelial growth factor receptor 1	FLT1	0.0075
3957	Adenosine deaminase	ADA	0.0074
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0074
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0074
1656	CYP2B protein	CYP2B	0.0074
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0072
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0072
823	Fibroblast growth factor receptor 2	FGFR2	0.0072
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
718	Folate receptor gamma	FOLR3	0.0071
299	Folate receptor beta	FOLR2	0.0071
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0071
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0071
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0071
6171	Solute carrier family 28 member 3	SLC28A3	0.007
6182	Cytochrome P450 2J2	CYP2J2	0.007
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0069
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0069
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
29	Tubulin beta-1 chain	TUBB1	0.0067
1039	Histone deacetylase 9	HDAC9	0.0067
427	Substance-P receptor	TACR1	0.0067
165	FL cytokine receptor	FLT3	0.0066
36	Insulin receptor	INSR	0.0066
2236	Casein kinase II subunit alpha	CSNK2A1	0.0066
4210	Toll-like receptor 4	TLR4	0.0066
6501	Fatty acid-binding protein, liver	FABP1	0.0065
3809	Estrogen-related receptor gamma	ESRRG	0.0065
661	ADP/ATP translocase 1	SLC25A4	0.0064
3808	Dihydropteroate synthase 2	folP2	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0064
3807	Dihydropteroate synthase 1	folP1	0.0064
6151	Monocarboxylate transporter 10	SLC16A10	0.0064
477	DNA topoisomerase 4 subunit A	parC	0.0064
886	DNA topoisomerase 4 subunit A	parC	0.0064
6226	DNA topoisomerase 4 subunit A	parC	0.0064
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0063
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0063
1291	cAMP response element-binding protein	CREB1	0.0063
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0063
133	Dihydropterate synthase	sulI	0.0063
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0062
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0062
88	Retinoic acid receptor RXR-beta	RXRB	0.0062
469	Annexin A1	ANXA1	0.0062
822	Aldose reductase	AKR1B1	0.0062
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0061
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
2391	Ferrochelatase	hemH	0.006
6502	Ferrochelatase	DKFZp686P18130	0.006
1591	Ferrochelatase, mitochondrial	FECH	0.006
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
1541	Metalloproteinase	mmp20	0.006
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
1192	Sulfotransferase 1A1	SULT1A1	0.0059
7	Nitric oxide synthase, inducible	NOS2	0.0058
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0058
6122	Carbonic anhydrase 3	CA3	0.0058
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0058
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0057
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
3939	Amine oxidase [flavin-containing] B	MAOB	0.0057
713	Sodium-dependent dopamine transporter	SLC6A3	0.0057
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0056
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0055
3007	Carbonic anhydrase 12	CA12	0.0055
4205	Carbonic anhydrase 9	CA9	0.0055
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0055
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
766	Beta-2 adrenergic receptor	ADRB2	0.0055
828	Phenylalanine-4-hydroxylase	PAH	0.0054
3109	Phenylalanine-4-hydroxylase	phhA	0.0054
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0054
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
1517	Beta-3 adrenergic receptor	ADRB3	0.0053
908	Glutathione S-transferase theta-1	GSTT1	0.0053
818	50S ribosomal protein L10	rplJ	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0052
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0052
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0052
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0052
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0052
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0052
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0052
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0052
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0052
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0052
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0052
6559	Cytochrome c oxidase subunit 2	ctaC	0.0052
6669	Cytochrome c oxidase subunit 2	ctaC	0.0052
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0052
6558	Cytochrome c oxidase subunit 1	ctaD	0.0052
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
318	Alpha-2A adrenergic receptor	ADRA2A	0.0052
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0052
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0051
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0051
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0051
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.005
1010	Cytochrome P450 51A1	CYP51A1	0.005
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0049
1629	Transcription factor AP-1	JUN	0.0049
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0048
2540	Choloylglycine hydrolase	cbh	0.0048
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0048
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0047
1196	Complement decay-accelerating factor	CD55	0.0046
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0046
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0046
707	72 kDa type IV collagenase	MMP2	0.0046
789	Alpha-1D adrenergic receptor	ADRA1D	0.0046
162	Retinoic acid receptor gamma-1	RARG	0.0046
94	5-hydroxytryptamine 4 receptor	HTR4	0.0045
6146	High affinity copper uptake protein 1	SLC31A1	0.0045
5924	Microtubule-associated protein 4	MAP4	0.0045
5923	Microtubule-associated protein tau	MAPT	0.0045
291	Nitric-oxide synthase, endothelial	NOS3	0.0045
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0044
5934	Cytochrome P450 26A1	CYP26A1	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0044
1618	High affinity nerve growth factor receptor	NTRK1	0.0044
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0044
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0044
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0044
780	Retinoic acid receptor RXR-gamma	RXRG	0.0044
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0044
49	Endothelin B receptor	EDNRB	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
2207	Rhodopsin	RHO	0.0043
268	Adenosine A2b receptor	ADORA2B	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
571	Melatonin receptor type 1A	MTNR1A	0.0042
362	Melatonin receptor type 1B	MTNR1B	0.0042
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0041
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0041
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0041
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0041
6677	Myelin P2 protein	PMP2	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
408	Riboflavin kinase	RFK	0.0041
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0041
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0041
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0041
1630	Integrin beta-2	ITGB2	0.0041
4203	Histamine N-methyltransferase	HNMT	0.0041
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
2808	Chloramphenicol acetyltransferase 3	cat3	0.0041
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.004
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.004
976	Platelet glycoprotein IX	GP9	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
730	Retinoic acid receptor alpha	RARA	0.004
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0039
702	UMP-CMP kinase	CMPK1	0.0039
751	Potassium channel subfamily K member 6	KCNK6	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0038
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0038
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0038
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0038
517	Alcohol dehydrogenase 1C	ADH1C	0.0038
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0038
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0038
284	DNA-directed RNA polymerase beta chain	rpoB	0.0038
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0038
1992	Vitamin D-binding protein	GC	0.0037
921	Glutamate receptor 2	GRIA2	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
2417	Chloramphenicol acetyltransferase	cat	0.0037
3278	Chloramphenicol acetyltransferase	cat	0.0037
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
2810	Dr hemagglutinin structural subunit	draA	0.0037
4120	NADPH--cytochrome P450 reductase	POR	0.0037
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0037
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0035
172	Potassium channel subfamily K member 1	KCNK1	0.0035
997	Protein kinase C beta type	PRKCB	0.0035
518	Peroxidase/catalase T	katG	0.0035
106	Cannabinoid receptor 2	CNR2	0.0035
5787	Angiopoietin-1 receptor	TEK	0.0035
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0034
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0034
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
68	Cannabinoid receptor 1	CNR1	0.0033
6044	Serum paraoxonase/lactonase 3	PON3	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0033
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0033
4103	Proteasome subunit beta type 2	PSMB2	0.0033
4102	Proteasome subunit beta type 5	PSMB5	0.0033
4101	Proteasome subunit beta type 1	PSMB1	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
2408	Tyrosine-protein kinase SYK	SYK	0.0032
4192	DNA topoisomerase 2-beta	TOP2B	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
572	Integrin alpha-L	ITGAL	0.0031
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.003
193	Beta-1 adrenergic receptor	ADRB1	0.003
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.003
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.003
654	Flavin reductase	BLVRB	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3830	Calreticulin	CALR	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
716	5-hydroxytryptamine 7 receptor	HTR7	0.0028
5431	Lipid binding protein	Not Available	0.0028
3616	Fatty acid-binding protein, epidermal	FABP5	0.0028
5433	UPF0230 protein TM_1468	TM_1468	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
5126	Arginase	rocF	0.0027
1025	Aquaporin-1	AQP1	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6034	Hydroxyindole O-methyltransferase	ASMT	0.0027
6035	Nuclear receptor ROR-beta	RORB	0.0027
6036	Eosinophil peroxidase	EPX	0.0027
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0026
54	Prothrombin	F2	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
1864	RET proto-oncogene	RET	0.0026
638	D(3) dopamine receptor	DRD3	0.0026
6174	50S ribosomal protein L32	rpmF	0.0025
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0025
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0025
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0025
740	Argininosuccinate synthase	ASS1	0.0025
865	Argininosuccinate synthase	ASS1	0.0025
2680	Argininosuccinate synthase	argG	0.0025
3194	Argininosuccinate synthase	argG	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
629	Alpha-2B adrenergic receptor	ADRA2B	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
3814	Complement C1r subcomponent	C1R	0.0024
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0024
6138	Multidrug resistance protein 3	ABCB4	0.0024
5300	Antigen peptide transporter 1	TAP1	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0024
765	Indoleamine 2,3-dioxygenase	IDO1	0.0023
283	SEC14-like protein 2	SEC14L2	0.0023
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0022
1374	Natriuretic peptides B	NPPB	0.0022
1525	Heparin-binding growth factor 2	FGF2	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
1827	Gap junction alpha-1 protein	GJA1	0.0022
1908	Vascular cell adhesion protein 1	VCAM1	0.0022
6459	Glycodelin	PAEP	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3086	Plasmepsin-2	Not Available	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0021
6168	Solute carrier family 22 member 16	SLC22A16	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0021
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0021
896	Glutathione S-transferase Mu 1	GSTM1	0.0021
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
768	FK506-binding protein 1A	FKBP1A	0.002
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.002
153	Dopamine beta-hydroxylase	DBH	0.002
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0019
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
161	Tubulin beta chain	TUBB	0.0018
312	Tubulin beta chain	TUB2	0.0018
3856	Fibroblast growth factor receptor 3	FGFR3	0.0018
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0018
3937	Fatty-acid amide hydrolase	FAAH	0.0018
319	Opioid receptor, sigma 1	OPRS1	0.0017
4948	Cytochrome c-553	Not Available	0.0017
4923	Cytochrome c3	DvMF_2499	0.0017
4945	Cytochrome c3	Not Available	0.0017
4949	Cytochrome c3	DVU_3171	0.0017
4968	Cytochrome c3	cytc3	0.0017
4997	Cytochrome c3	SO_2727	0.0017
5219	Cytochrome c3	cyd	0.0017
3189	High-molecular-weight cytochrome c	hmcA	0.0017
4902	Nine-heme cytochrome c	Ddes_2038	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0017
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
2112	Toll-like receptor 9	TLR9	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0017
378	Alpha-2C adrenergic receptor	ADRA2C	0.0017
432	D(4) dopamine receptor	DRD4	0.0017
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0016
2300	Lysozyme	E	0.0016
3633	Lysozyme	R	0.0016
5597	Lysozyme	17	0.0016
6163	Copper-transporting ATPase 2	ATP7B	0.0016
6165	Copper-transporting ATPase 1	ATP7A	0.0016
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0016
814	Ryanodine receptor 1	RYR1	0.0016
4311	tRNA	TRDMT1	0.0016
4325	tRNA	trmD	0.0016
4328	tRNA	trmD	0.0016
4943	Cytochrome c6	petJ	0.0015
4954	Soluble cytochrome b558	Not Available	0.0015
4947	Bacterial hemoglobin	vhb	0.0015
4934	Cytochrome c-551	nirM	0.0015
5218	Cytochrome c-551	nirM	0.0015
4905	Cytochrome c2	Not Available	0.0015
4939	Cytochrome c2	cycA	0.0015
4964	Cytochrome c2	cycA	0.0015
4979	Cytochrome c2	cycA	0.0015
6673	Cytochrome c2	cycA	0.0015
4916	Cyanoglobin	glbN	0.0015
4984	Neuroglobin	NGB	0.0015
4925	Cytochrome c-type protein SHP	shp	0.0015
4994	Hemoglobin-like protein HbO	glbO	0.0015
4942	Diheme cytochrome c napB	napB	0.0015
4915	Cytochrome c-550	psbV	0.0015
4959	Cytochrome c-550	psbV	0.0015
5216	Cytochrome c-550	psbV	0.0015
4975	Cytochrome c-556	RPA3973	0.0015
4998	Hemoglobin-like protein yjbI	yjbI	0.0015
4936	Cytochrome c2 iso-2	Not Available	0.0015
4961	Hemophore HasA	hasA	0.0015
5000	HemO	hemO	0.0015
4981	Iron-starvation protein PigA	pigA	0.0015
4910	Cytoglobin	CYGB	0.0015
644	Heme oxygenase 2	HMOX2	0.0015
4982	Heme oxygenase 2	pbsA2	0.0015
4909	CooA protein	cooA	0.0015
3116	Bacterioferritin	bfr	0.0015
4906	Bacterioferritin	bfr	0.0015
4965	Bacterioferritin	bfr	0.0015
4904	Cytochrome c family protein	GSU1996	0.0015
4935	Cytochrome c-554	cycA1	0.0015
4907	Cytochrome c-L	moxG	0.0015
6865	Cytochrome c-L	moxG	0.0015
4971	Nonaheme cytochrome c	hmcA	0.0015
4976	Apocytochrome f	petA	0.0015
6407	Apocytochrome f	petA	0.0015
4937	Cytochrome oxidase subunit II	rcoxA	0.0015
4989	Cytochrome c551 peroxidase	ccp	0.0015
5222	Cytochrome c551 peroxidase	ccpA	0.0015
4764	Cytochrome P450 165C4	CYP165C4	0.0015
4999	Cytochrome P450 165B3	CYP165B3	0.0015
4931	Cytochrome P450 167A1	CYP167A1	0.0015
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0015
4960	Putative cytochrome P450-family protein	SCO7417	0.0015
4972	P450cin	cinA	0.0015
4903	Methyl-accepting chemotaxis protein	Tar4	0.0015
4922	Cytochrome c, putative	SO_4144	0.0015
4993	Hydroxylamine oxidoreductase	hao1	0.0015
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0015
4952	Catalase/peroxidase	katA	0.0015
3093	Catalase HPII	katE	0.0015
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0015
239	Coagulation factor X	F10	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
164	Histamine H4 receptor	HRH4	0.0015
4386	Hemoglobin-like protein HbN	glbN	0.0015
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0015
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0015
174	Sigma 1-type opioid receptor	SIGMAR1	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
6048	Troponin C, skeletal muscle	TNNC2	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
2539	Tubulin alpha-1 chain	TUBA4A	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0014
2232	Interleukin-5	IL5	0.0014
3221	Cytochrome c4	cc4	0.0014
1593	Mucin-2	MUC2	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0013
1268	Neuropeptide S receptor	NPSR1	0.0013
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0013
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0013
856	Vitamin D3 receptor	VDR	0.0013
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0013
1262	Corticotropin-lipotropin	POMC	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
4034	Glutaredoxin-1	GLRX	0.0013
6432	Transporter	snf	0.0013
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0013
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0013
910	Epididymal secretory glutathione peroxidase	GPX5	0.0013
4036	Glutathione peroxidase 6	GPX6	0.0013
903	Glutathione S-transferase A5	GSTA5	0.0013
911	Glutathione peroxidase 3	GPX3	0.0013
4037	Hypothetical protein	GPX1	0.0013
4297	Hypothetical protein	SP_1951	0.0013
4521	Hypothetical protein	BC_2969	0.0013
4540	Hypothetical protein	TM_1070	0.0013
4555	Hypothetical protein	MT1739	0.0013
4569	Hypothetical protein	mshD	0.0013
4578	Hypothetical protein	PA3270	0.0013
4747	Hypothetical protein	PA3967	0.0013
5177	Hypothetical protein	TM_0096	0.0013
5194	Hypothetical protein	PA1204	0.0013
5240	Hypothetical protein	Rv2991	0.0013
5370	Hypothetical protein	TM_1158	0.0013
5710	Hypothetical protein	Tb927.5.1360	0.0013
1928	Leukotriene C4 synthase	LTC4S	0.0013
4029	Microsomal glutathione S-transferase 3	MGST3	0.0013
4032	Microsomal glutathione S-transferase 1	MGST1	0.0013
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0013
4040	Glutathione peroxidase 7	GPX7	0.0013
907	Glutathione peroxidase 2	GPX2	0.0013
906	Glutathione peroxidase 1	GPX1	0.0013
4035	Glutathione S-transferase Mu 5	GSTM5	0.0013
900	Glutathione S-transferase A4	GSTA4	0.0013
4042	Glutathione transferase omega-2	GSTO2	0.0013
4033	S-formylglutathione hydrolase	ESD	0.0013
4038	Glutathione peroxidase 4	GPX4	0.0013
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0013
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0013
5798	Mitogen-activated protein kinase 11	MAPK11	0.0013
267	Plasminogen activator inhibitor 1	SERPINE1	0.0012
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0012
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0012
6073	Potassium channel subfamily K member 9	KCNK9	0.0012
6072	Potassium channel subfamily K member 3	KCNK3	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0012
4920	Peroxidase/catalase	katG	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
474	Acetylcholinesterase	ACHE	0.0011
2119	Cytochrome b5	CYB5A	0.0011
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0011
4990	PpcA	ppcA	0.0011
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0011
4289	Cytochrome P450	TT_P0059	0.0011
6262	Cytochrome P450	staP	0.0011
3570	Cytochrome P450 152A1	cypC	0.0011
4988	Sulfite oxidase, mitochondrial	SUOX	0.0011
4992	Cytochrome c peroxidase	Not Available	0.0011
3375	Acidic cytochrome c3	Not Available	0.0011
2915	Sensor protein fixL	fixL	0.0011
4944	Sensor protein fixL	fixL	0.0011
897	Glutathione S-transferase kappa 1	GSTK1	0.0011
4385	Cytochrome c'	Not Available	0.0011
4967	Cytochrome c'	cycA	0.0011
5038	Cytochrome c'	Not Available	0.0011
5223	Cytochrome c'	cycP	0.0011
898	Glutathione S-transferase A3	GSTA3	0.0011
4813	Heme oxygenase	hmuO	0.0011
5769	Heme oxygenase	Not Available	0.0011
909	Maleylacetoacetate isomerase	GSTZ1	0.0011
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
6221	Steroid hormone receptor ERR1	ESRRA	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0011
3913	Glutamic acid decarboxylase	GAD65	0.0011
2230	Catalase	CAT	0.0011
3249	Catalase	katA	0.0011
3625	Catalase	katA	0.0011
4539	Catalase	katA	0.0011
4941	Catalase	katB	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
899	Glutathione S-transferase Mu 3	GSTM3	0.0011
905	Glutathione transferase omega-1	GSTO1	0.0011
4041	Microsomal glutathione S-transferase 2	MGST2	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0011
1483	Membrane copper amine oxidase	AOC3	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
563	Thyroid peroxidase	TPO	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
3670	Soluble cytochrome b562 precursor	cybC	0.001
3411	Cytochrome P450 121	cyp121	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
2165	Glutathione S-transferase Mu 2	GSTM2	0.001
2617	Nitric oxide synthase oxygenase	nos	0.001
2701	Nitric oxide synthase oxygenase	nos	0.001
3291	Cytochrome c-552	cycA	0.001
4927	Cytochrome c-552	nrfA	0.001
4938	Cytochrome c-552	cycA	0.001
4953	Cytochrome c-552	nrfA	0.001
5217	Cytochrome c-552	cycM	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
207	Glutathione synthetase	GSS	0.001
5269	Glutathione synthetase	gshB	0.001
3102	Flavohemoprotein	hmp	0.001
4969	Flavohemoprotein	hmp	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
936	Ephrin type-A receptor 2	EPHA2	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
1353	DNA topoisomerase 1	TOP1	0.0009
3552	DNA topoisomerase 1	topA	0.0009
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0009
2216	Fibroblast growth factor receptor 4	FGFR4	0.0009
163	D(1B) dopamine receptor	DRD5	0.0009
901	Glutathione S-transferase Mu 4	GSTM4	0.0009
735	Alanine aminotransferase 1	GPT	0.0009
3904	Alanine aminotransferase 2	GPT2	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0009
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0009
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0009
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0009
605	Fumarate reductase flavoprotein subunit	frdA	0.0009
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0009
3673	Fumarate reductase flavoprotein subunit	fccA	0.0009
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0009
6549	Fumarate reductase flavoprotein subunit	frdA	0.0009
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
1184	Interferon beta	IFNB1	0.0008
4608	Putative cytochrome P450	SCO1207	0.0008
4963	Putative cytochrome P450	SCO2884	0.0008
6254	Putative cytochrome P450	SCO6998	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
714	Glutathione reductase, mitochondrial	GSR	0.0008
358	Cystathionine beta-synthase	CBS	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0008
693	Hemoglobin subunit beta	HBB	0.0008
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6268	Hydroxyacid oxidase 1	HAO1	0.0007
6824	Tyrosine-protein kinase Lyn	LYN	0.0007
810	Heme oxygenase 1	HMOX1	0.0007
3391	Heme oxygenase 1	pbsA1	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
2298	Cytochrome P450-cam	camC	0.0006
251	Alcohol dehydrogenase 1A	ADH1A	0.0006
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0005
2430	Chondroitinase B	cslB	0.0005
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
5961	Insulin	INS	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
6755	Poliovirus receptor	PVR	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01009 - Ketoprofen

Targets

Enzymes

Transporters

Carriers

Predictions