DT-Web: DB00945

Identification

Name

Acetylsalicylic acid

Accession Number

DB00945 (APRD00264, EXPT00475)

Type

small molecule

Description

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

180.1574

Groups

approved

Monoisotopic Weight

180.042258744

Pharmacology

Indication

For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.

Mechanism of action

The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Acetylsalicylic acid directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes acetylsalicylic acid different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Acetylsalicylic acid's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation-inhibiting effect of acetylsalicylic acid specifically involves the compound's ability to act as an acetyl donor to cyclooxygenase; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Irreversible acetylation renders cyclooxygenase inactive, thereby preventing the formation of the aggregating agent thromboxane A2 in platelets. Since platelets lack the ability to synthesize new proteins, the effects persist for the life of the exposed platelets (7-10 days). Acetylsalicylic acid may also inhibit production of the platelet aggregation inhibitor, prostacyclin (prostaglandin I2), by blood vessel endothelial cells; however, inhibition prostacyclin production is not permanent as endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.

Absorption

Absorption is generally rapid and complete following oral administration but may vary according to specific salicylate used, dosage form, and other factors such as tablet dissolution rate and gastric or intraluminal pH.

Protein binding

High (99.5%) to albumin. Decreases as plasma salicylate concentration increases, with reduced plasma albumin concentration or renal dysfunction, and during pregnancy.

Biotransformation

Acetylsalicylic acid is rapidly hydrolyzed primarily in the liver to salicylic acid, which is conjugated with glycine (forming salicyluric acid) and glucuronic acid and excreted largely in the urine.

Route of elimination

Not Available

Toxicity

Oral, mouse: LD₅₀ = 250 mg/kg; Oral, rabbit: LD₅₀ = 1010 mg/kg; Oral, rat: LD₅₀ = 200 mg/kg. Effects of overdose include: tinnitus, abdominal pain, hypokalemia, hypoglycemia, pyrexia, hyperventilation, dysrhythmia, hypotension, hallucination, renal failure, confusion, seizure, coma, and death.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Acetylsalicylic acid increases the effect of the anticoagulant, acenocoumarol.
Acetazolamide	Acetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, acetazolamide.
Acetohexamide	Acetylsalicylic acid increases the effect of sulfonylurea, acetohexamide.
Anisindione	Acetylsalicylic acid increases effect of the anticoagulant, anisindione.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Betamethasone	The corticosteroid, betamethasone, may decrease the effect of the salicylate, acetylsalicylic acid.
Chlorpropamide	Acetylsalicylic acid may increase the effect of the sulfonylurea, chlorpropamide.
Cortisone acetate	The corticosteroid, cortisone acetate, may decrease the effect of the salicylate, acetylsalicylic acid.
Dexamethasone	The corticosteroid, dexamethasone, may decrease the effect of the salicylate, acetylsalicylic acid.
Dichlorphenamide	Acetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, dichlorphenamide.
Dicumarol	Acetylsalicylic acid increases effect of the anticoagulant, dicumarol.
Eltrombopag	Decreases metabolism, will increase effect/level of eltrombopag.
Fludrocortisone	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, acetylsalicylic acid.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Gliclazide	Acetylsalicylic acid increases the effect of the sulfonylurea, gliclazide.
Glipizide	Acetylsalicylic acid increases the effect of the sulfonylurea, glipizide.
Glisoxepide	Acetylsalicylic acid increases the effect of the sulfonylurea, glisoxepide.
Glyburide	Acetylsalicylic acid increases the effect of the sulfonylurea, glibenclamide.
Glycodiazine	Acetylsalicylic acid increases the effect of sulfonylurea, glycodiazine.
Griseofulvin	Griseofulvin may decrease the efficacy of acetylsalicylic acid.
Heparin	Increased risk of bleeding.
Homoharringtonine	Avoid combination with acetylsalicylic acid due to the potential enhancement of homoharringtonine associated bleeding-related adverse effects. Specifically it is suggested to avoid this combination in patients with a platelet count of less than 50,000/uL.
Hydrocortisone	The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, acetylsalicylic acid.
Ibuprofen	Concomitant therapy of the NSAID, ketoprofen, and acetylsalicylic acid may result in additive adverse/toxic effects (e.g. GI bleeding). The NSAID may also limit the cardioprotective effect of acetylsalicylic acid. Occasional concomitant use may not cause clinically significant problems, but regular, frequent concomitant therapy is not recommended.
Ketoprofen	Concomitant therapy of the NSAID, ketoprofen, and acetylsalicylic acid may result in additive adverse/toxic effects (e.g. GI bleeding). The NSAID may also limit the cardioprotective effect of acetylsalicylic acid. Occasional concomitant use may not cause clinically significant problems, but regular, frequent concomitant therapy is not recommended.
Ketorolac	Acetylsalicylic acid may increase the adverse GI effects ketorolac.
Methazolamide	Acetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Methotrexate	Acetylsalicylic acid increases the effect and toxicity of methotrexate.
Methylprednisolone	The corticosteroid, methylprednisolone, may decrease the effect of the salicylate, acetylsalicylic acid.
Paramethasone	The corticosteroid, paramethasone, may decrease the effect of the salicylate, acetylsalicylic acid.
Prednisolone	The corticosteroid, prednisolone, may decrease the effect of the salicylate, acetylsalicylic acid.
Prednisone	The corticosteroid, prednisone, may decrease the effect of the salicylate, acetylsalicylic acid.
Probenecid	Acetylsalicylic acid decreases the uricosuric effect of probenecid.
Sulindac	Risk of additive toxicity (e.g. bleed risk). Acetylsalicylic acid may decrease the serum concentration of sulindac. Sulindac may counteract the cardioprotective effects of acetylsalicylic acid. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if the interacting agent is initiated, discontinued or dose changed.
Telmisartan	Concomitant use of Telmisartan and Acetylsalicylic acid may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Tiaprofenic acid	Increased risk of gastrointestinal bleeding.
Ticlopidine	Increased effect of ticlopidine
Tolazamide	Acetylsalicylic acid increases the effect of the sulfonylurea, tolazamide.
Tolbutamide	Acetylsalicylic acid increases the effect of the sulfonylurea, tolbutamide.
Tolmetin	Additive adverse effects increase the risk of gastrointestinal bleeding. Possible decrease in the cardioprotective effect of acetylsalicylic acid. Monitor for increased bleeding risk during concomitant therapy.
Trandolapril	Acetylsalicylic acid may reduce the efficacy of Trandolapril. Monitor for changes in Trandolapril efficacy if Acetylsalicylic acid is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Acetylsalicylic acid. Monitor for increased bleeding during concomitant thearpy.
Triamcinolone	The corticosteroid, triamcinolone, may decrease the effect of the salicylate, acetylsalicylic acid.
Valproic Acid	Acetylsalicylic acid increases the effect of valproic acid.
Warfarin	The antiplatelet effects of acetylsalicylic acid may increase the bleed risk associated with warfarin.

Food Interactions

Avoid alcohol, alcohol appears to cause a 50 to 100% increases in ASA serum levels.
Take with a full glass of water.
Take with food to reduce gastric irritation.

Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	yes
Actions	inhibitor
References	Stevenson DD, Szczeklik A: Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immunol. 2006 Oct;118(4):773-86; quiz 787-8. Epub 2006 Sep 1. - Pubmed Flipo RM: [Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?] Presse Med. 2006 Sep;35(9 Spec No 1):1S53-60. - Pubmed Schwartz KA: Aspirin resistance: a review of diagnostic methodology, mechanisms, and clinical utility. Adv Clin Chem. 2006;42:81-110. - Pubmed Birnbaum Y, Ye Y, Lin Y, Freeberg SY, Huang MH, Perez-Polo JR, Uretsky BF: Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart. Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):89-98. Epub 2006 Nov 7. - Pubmed Guthikonda S, Lev EI, Patel R, DeLao T, Bergeron AL, Dong JF, Kleiman NS: Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. J Thromb Haemost. 2007 Mar;5(3):490-6. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6922
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Brzozowski T, Konturek PC, Sliwowski Z, Kwiecien S, Drozdowicz D, Pawlik M, Mach K, Konturek SJ, Pawlik WW: Interaction of nonsteroidal anti - inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. J Physiol Pharmacol. 2006 Sep;57 Suppl 3:67-79. - Pubmed Wang HJ, Liu XJ, Yang KX, Luo FM, Lou JY, Peng ZL: [Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma cell] Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Sep;37(5):757-60. - Pubmed Shen J, Gammon MD, Terry MB, Teitelbaum SL, Neugut AI, Santella RM: Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. Breast Cancer Res. 2006;8(6):R71. - Pubmed Nakano M, Denda N, Matsumoto M, Kawamura M, Kawakubo Y, Hatanaka K, Hiramoto Y, Sato Y, Noshiro M, Harada Y: Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation. Eur J Pharmacol. 2007 Mar 22;559(2-3):210-8. Epub 2006 Dec 16. - Pubmed Hall MN, Campos H, Li H, Sesso HD, Stampfer MJ, Willett WC, Ma J: Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):314-21. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6102
Aldo-keto reductase family 1 member C1
Name	Aldo-keto reductase family 1 member C1
Gene Name	AKR1C1
Pharmacological action	unknown
Actions	inhibitor
References	Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O: A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase. Med Chem. 2007 Nov;3(6):546-50. - Pubmed
DTHybrid score	0.5114

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4017
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3733
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5556

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score	0.4188
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.3958
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate
References	Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score	0.2089

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.4188
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.3958
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.2089

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.4045
4200	Cytochrome P450 1A2	CYP1A2	0.2351
4119	Cytochrome P450 2D6	CYP2D6	0.2276
6142	Solute carrier family 22 member 8	SLC22A8	0.1846
4118	Cytochrome P450 3A5	CYP3A5	0.1704
1024	Solute carrier family 22 member 11	SLC22A11	0.1439
6030	Cytochrome P450 2B6	CYP2B6	0.1364
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.1313
6013	Cytochrome P450 2E1	CYP2E1	0.1257
6107	Cytochrome P450 3A7	CYP3A7	0.1181
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1054
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0983
6024	Cytochrome P450 1A1	CYP1A1	0.089
5718	Cytochrome P450 2A6	CYP2A6	0.0868
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0847
578	Endothelin-1 receptor	EDNRA	0.0827
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0814
2164	Multidrug resistance-associated protein 4	ABCC4	0.078
373	Transthyretin	TTR	0.0779
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0775
862	Multidrug resistance-associated protein 1	ABCC1	0.0712
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0691
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.069
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0678
6106	Cytochrome P450 2C18	CYP2C18	0.0664
275	Arachidonate 5-lipoxygenase	ALOX5	0.0569
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.055
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0534
6145	Solute carrier family 22 member 1	SLC22A1	0.0531
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0494
738	Monocarboxylate transporter 1	SLC16A1	0.0487
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0458
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0453
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0452
6144	Solute carrier family 22 member 2	SLC22A2	0.0441
118	Organic cation/carnitine transporter 2	SLC22A5	0.0429
1757	Myeloperoxidase	MPO	0.0392
776	Bile salt export pump	ABCB11	0.0388
492	Histamine H1 receptor	HRH1	0.0383
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0377
891	Dihydropteroate synthase	folP	0.0376
5359	Dihydropteroate synthase	folP	0.0376
7175	Dihydropteroate synthase	sulI	0.0376
1898	Cytochrome P450 1B1	CYP1B1	0.0368
824	Sodium-dependent serotonin transporter	SLC6A4	0.0342
6149	Solute carrier family 22 member 10	SLC22A10	0.0339
3811	Cytochrome P450 19A1	CYP19A1	0.0337
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0331
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0319
6141	Sodium/bile acid cotransporter	SLC10A1	0.0311
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0304
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0303
6136	Multidrug resistance-associated protein 5	ABCC5	0.0302
146	Androgen receptor	AR	0.0294
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0286
3923	Cholinesterase	BCHE	0.0284
831	D(2) dopamine receptor	DRD2	0.0274
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0273
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0267
136	Estrogen receptor	ESR1	0.0264
556	Alpha-1A adrenergic receptor	ADRA1A	0.0259
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0258
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0251
70	Type-1 angiotensin II receptor	AGTR1	0.0248
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0245
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0238
558	Solute carrier family 12 member 1	SLC12A1	0.0236
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.023
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.023
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0225
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0224
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0221
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0221
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0217
3312	Fatty acid-binding protein, brain	FABP7	0.0217
6031	Cytochrome P450 3A43	CYP3A43	0.0216
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0216
260	Cytochrome P450 51	ERG11	0.0213
761	Cytochrome P450 51	ERG11	0.0213
3163	Cytochrome P450 51	cyp51	0.0213
633	Penicillin-binding proteins 1A/1B	pbpA	0.0212
871	Glucocorticoid receptor	NR3C1	0.0211
6137	Multidrug resistance-associated protein 6	ABCC6	0.0204
672	Prostaglandin F2-alpha receptor	PTGFR	0.0204
777	Tumor necrosis factor	TNF	0.0203
731	HIV-1 protease	HIV-1 protease	0.0203
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0202
3941	Amine oxidase [flavin-containing] A	MAOA	0.0201
592	Carbonic anhydrase 4	CA4	0.0199
122	P2Y purinoceptor 12	P2RY12	0.0199
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0198
645	Penicillin-binding protein 1A	mrcA	0.0197
5805	Penicillin-binding protein 1A	ponA	0.0197
6185	Penicillin-binding protein 1A	mrcA	0.0197
6799	Penicillin-binding protein 1A	pbpA	0.0197
6102	Arylamine N-acetyltransferase 2	NAT2	0.0195
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0192
23	D(1A) dopamine receptor	DRD1	0.0192
833	Organic cation/carnitine transporter 1	SLC22A4	0.0191
4604	Liver carboxylesterase 1	CES1	0.0191
3947	Xanthine dehydrogenase/oxidase	XDH	0.019
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.019
6148	Multidrug resistance-associated protein 7	ABCC10	0.0189
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0189
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0188
295	Carbonic anhydrase 1	CA1	0.0188
1159	Interleukin-6	IL6	0.0185
766	Beta-2 adrenergic receptor	ADRB2	0.0185
338	DNA polymerase	UL30	0.0185
379	DNA polymerase	UL54	0.0185
697	DNA polymerase	ORF28	0.0185
2482	DNA polymerase	43	0.0185
4104	DNA polymerase	BALF5	0.0185
632	Alpha-1B adrenergic receptor	ADRA1B	0.0185
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0185
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0185
817	DNA topoisomerase 2-alpha	TOP2A	0.0185
6085	Fatty acid-binding protein, intestinal	FABP2	0.0184
696	Kappa-type opioid receptor	OPRK1	0.0183
6147	Solute carrier family 22 member 3	SLC22A3	0.0183
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0181
847	Mu-type opioid receptor	OPRM1	0.0181
51	Muscarinic acetylcholine receptor M3	CHRM3	0.018
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.018
468	Cytochrome P450 4A11	CYP4A11	0.0178
22	30S ribosomal protein S4	rpsD	0.0177
6714	30S ribosomal protein S4	rpsD	0.0177
723	Cytosolic phospholipase A2	PLA2G4A	0.0176
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0175
543	Penicillin-binding protein 1B	mrcB	0.0175
6186	Penicillin-binding protein 1B	ponB	0.0175
6822	Penicillin-binding protein 1b	pbp1b	0.0175
6844	Penicillin-binding protein 1b	pbp1b	0.0175
404	DNA gyrase subunit A	gyrA	0.0174
6224	DNA gyrase subunit A	gyrA	0.0174
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0173
467	Delta-type opioid receptor	OPRD1	0.0173
6033	High affinity interleukin-8 receptor A	CXCR1	0.0172
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0171
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0169
357	Carbonic anhydrase 2	CA2	0.0168
183	Vascular endothelial growth factor A	VEGFA	0.0168
1507	Cytochrome c	CYCS	0.0167
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0167
140	30S ribosomal protein S9	rpsI	0.0167
6719	30S ribosomal protein S9	rpsI	0.0167
6725	30S ribosomal protein S9	rpsI	0.0167
3639	Thymidine phosphorylase	deoA	0.016
3936	Thymidine phosphorylase	TYMP	0.016
193	Beta-1 adrenergic receptor	ADRB1	0.016
844	Epidermal growth factor receptor	EGFR	0.0159
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0159
6043	Putative G-protein coupled receptor 44	GPR44	0.0158
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0158
244	Angiotensin-converting enzyme	ACE	0.0157
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0157
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0156
6182	Cytochrome P450 2J2	CYP2J2	0.0154
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0153
811	Translocator protein	TSPO	0.0153
756	Sex hormone-binding globulin	SHBG	0.0152
24	Thymidylate synthase	TMP1	0.0151
359	Thymidylate synthase	TYMS	0.0151
2626	Thymidylate synthase	thyA	0.0151
2729	Thymidylate synthase	thyA	0.0151
5352	Thymidylate synthase	THYA	0.0151
2183	Fatty acid-binding protein, adipocyte	FABP4	0.015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0148
380	Cytochrome P450 17A1	CYP17A1	0.0144
614	Progesterone receptor	PGR	0.0144
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0143
6220	Aryl hydrocarbon receptor	AHR	0.0143
465	Calmodulin	CALM1	0.0143
713	Sodium-dependent dopamine transporter	SLC6A3	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
365	Dihydrofolate reductase	DHFR	0.0142
2381	Dihydrofolate reductase	DFR1	0.0142
2833	Dihydrofolate reductase	Not Available	0.0142
2931	Dihydrofolate reductase	folA	0.0142
3544	Dihydrofolate reductase	folA	0.0142
3682	Dihydrofolate reductase	folA	0.0142
6642	Dihydrofolate reductase	folA	0.0142
6756	Dihydrofolate reductase	dfrA	0.0142
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.014
6020	Aldehyde oxidase	AOX1	0.0139
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0137
3939	Amine oxidase [flavin-containing] B	MAOB	0.0137
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0136
1	Peptidoglycan synthetase ftsI	ftsI	0.0135
4155	Peptidoglycan synthetase ftsI	ftsI	0.0135
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0133
703	NADPH azoreductase	azr	0.0132
185	Vasopressin V1a receptor	AVPR1A	0.0132
322	Vasopressin V2 receptor	AVPR2	0.0129
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0129
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0129
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0128
130	Prostacyclin synthase	PTGIS	0.0127
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0127
789	Alpha-1D adrenergic receptor	ADRA1D	0.0126
4120	NADPH--cytochrome P450 reductase	POR	0.0125
318	Alpha-2A adrenergic receptor	ADRA2A	0.0125
5353	Glutamate decarboxylase alpha	gadA	0.0125
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0124
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0124
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0123
850	Vasopressin V1b receptor	AVPR1B	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
6126	Carbonic anhydrase 7	CA7	0.0121
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0121
124	Histamine H2 receptor	HRH2	0.0121
1867	Major prion protein	PRNP	0.0121
4122	Histone deacetylase 2	HDAC2	0.0121
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0119
1192	Sulfotransferase 1A1	SULT1A1	0.0119
1648	Elastin	ELN	0.0119
2320	Thymidine kinase, cytosolic	TK1	0.0118
459	Retinoic acid receptor RXR-alpha	RXRA	0.0118
527	Prostacyclin receptor	PTGIR	0.0117
1178	Adenosine A2a receptor	ADORA2A	0.0116
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0116
504	Mast/stem cell growth factor receptor	KIT	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0113
115	Penicillin-binding protein 2	mrdA	0.0113
6069	Penicillin-binding protein 2	mrdA	0.0113
6118	Penicillin-binding protein 2	penA	0.0113
6187	Penicillin-binding protein 2	pbpA	0.0113
6686	Penicillin-binding protein 2	pbp2	0.0113
6939	Penicillin-binding protein 2	mrdA	0.0113
7163	Penicillin-binding protein 2	pbpA	0.0113
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0113
1656	CYP2B protein	CYP2B	0.0112
869	Estrogen receptor beta	ESR2	0.0112
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0109
6014	Cytochrome P450 2A13	CYP2A13	0.0109
16	Adenosine A1 receptor	ADORA1	0.0108
737	Mineralocorticoid receptor	NR3C2	0.0108
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0107
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0105
65	Matrix metalloproteinase-9	Not Available	0.0105
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0105
6207	30S ribosomal protein S14	rpsN	0.0104
6209	30S ribosomal protein S19	rpsS	0.0104
6712	30S ribosomal protein S19	rpsS	0.0104
6726	30S ribosomal protein S19	rpsS	0.0104
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0102
489	Monocarboxylate transporter 2	SLC16A7	0.0102
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0102
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0101
436	5-hydroxytryptamine 2B receptor	HTR2B	0.01
273	Apoptosis regulator Bcl-2	BCL2	0.01
2981	Phospholipase A2, membrane associated	PLA2G2A	0.01
477	DNA topoisomerase 4 subunit A	parC	0.0099
886	DNA topoisomerase 4 subunit A	parC	0.0099
6226	DNA topoisomerase 4 subunit A	parC	0.0099
4221	Vascular endothelial growth factor	VEGF	0.0099
5816	Cadherin-5	CDH5	0.0099
822	Aldose reductase	AKR1B1	0.0099
1439	Lactotransferrin	LTF	0.0098
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0098
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0098
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0096
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0096
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0096
823	Fibroblast growth factor receptor 2	FGFR2	0.0095
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0095
427	Substance-P receptor	TACR1	0.0095
566	Serotransferrin	TF	0.0094
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0094
1714	Mitogen-activated protein kinase 3	MAPK3	0.0094
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0094
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0093
818	50S ribosomal protein L10	rplJ	0.0093
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0092
1650	Heme carrier protein 1	SLC46A1	0.0092
29	Tubulin beta-1 chain	TUBB1	0.0092
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0092
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0091
482	Glycine receptor subunit alpha-1	GLRA1	0.0091
4217	Telomerase reverse transcriptase	TERT	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.009
3685	Catabolite gene activator	crp	0.0089
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0089
4655	Adenylate cyclase	cyaC	0.0089
4759	Adenylate cyclase	cyaB2	0.0089
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0089
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0088
4116	Dihydropteroate synthetase	Not Available	0.0087
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0087
1050	Bile salt sulfotransferase	SULT2A1	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
663	Solute carrier family 12 member 4	SLC12A4	0.0086
53	Solute carrier family 12 member 5	SLC12A5	0.0086
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0086
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0085
407	Vascular endothelial growth factor receptor 2	KDR	0.0085
3932	Glutathione S-transferase A2	GSTA2	0.0084
4773	Deoxycytidine kinase	DCK	0.0084
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0084
1275	Estrogen sulfotransferase	SULT1E1	0.0083
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0083
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0081
4238	50S ribosomal protein L4	rplD	0.0081
5578	50S ribosomal protein L4	rplD	0.0081
6173	50S ribosomal protein L4	rplD	0.0081
6219	50S ribosomal protein L4	rplD	0.0081
6103	Arylamine N-acetyltransferase 1	NAT1	0.008
310	Solute carrier family 12 member 2	SLC12A2	0.008
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
26	Vascular endothelial growth factor receptor 3	FLT4	0.0079
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0079
638	D(3) dopamine receptor	DRD3	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0078
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0077
161	Tubulin beta chain	TUBB	0.0077
312	Tubulin beta chain	TUB2	0.0077
819	Penicillin-binding protein 4	dacB	0.0077
2249	Aspartate aminotransferase	aspC	0.0077
2671	Aspartate aminotransferase	aspC	0.0077
5490	Aspartate aminotransferase	Not Available	0.0077
3760	Penicillin-binding protein 5 precursor	dacA	0.0077
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0077
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0077
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0077
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0077
4760	Mll3241 protein	mll3241	0.0076
654	Flavin reductase	BLVRB	0.0076
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0076
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0076
32	Vascular endothelial growth factor receptor 1	FLT1	0.0076
2021	Thrombomodulin	THBD	0.0075
3808	Dihydropteroate synthase 2	folP2	0.0074
3601	Dihydropteroate synthase 1	folP1	0.0074
3807	Dihydropteroate synthase 1	folP1	0.0074
4237	50S ribosomal protein L22	rplV	0.0074
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0072
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0072
3810	Catechol O-methyltransferase	COMT	0.0072
33	Cystine/glutamate transporter	SLC7A11	0.0072
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
6500	Phospholipase A2	PLA2G1B	0.0071
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0071
49	Endothelin B receptor	EDNRB	0.007
6042	Prostaglandin reductase 2	PTGR2	0.007
952	Dipeptidyl peptidase 4	DPP4	0.0069
88	Retinoic acid receptor RXR-beta	RXRB	0.0069
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0069
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0069
1618	High affinity nerve growth factor receptor	NTRK1	0.0068
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0068
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0068
629	Alpha-2B adrenergic receptor	ADRA2B	0.0067
2159	Quinone oxidoreductase	CRYZ	0.0067
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0067
1852	Microtubule-associated protein 2	MAP2	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
661	ADP/ATP translocase 1	SLC25A4	0.0067
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0066
36	Insulin receptor	INSR	0.0066
594	Thyroxine-binding globulin	SERPINA7	0.0066
904	Glutathione S-transferase P	GSTP1	0.0066
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0066
634	Squalene monooxygenase	SQLE	0.0066
7196	Squalene monooxygenase	ERG1	0.0066
5626	Nucleoside diphosphate kinase B	NME2	0.0065
1010	Cytochrome P450 51A1	CYP51A1	0.0065
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0065
867	Penicillin-binding protein 3	pbpC	0.0065
6119	Penicillin-binding protein 3	pbp3	0.0065
7154	Penicillin-binding protein 3	pbp3	0.0065
7157	Penicillin-binding protein 3	LMHCC_2184	0.0065
7162	Penicillin-binding protein 3	pbpB	0.0065
7172	Penicillin-binding protein 3	pbp3	0.0065
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0065
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0065
4103	Proteasome subunit beta type 2	PSMB2	0.0064
4102	Proteasome subunit beta type 5	PSMB5	0.0064
4101	Proteasome subunit beta type 1	PSMB1	0.0064
1654	Interleukin-1 beta	IL1B	0.0064
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0064
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0064
716	5-hydroxytryptamine 7 receptor	HTR7	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
1629	Transcription factor AP-1	JUN	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
7	Nitric oxide synthase, inducible	NOS2	0.0063
133	Dihydropterate synthase	sulI	0.0063
921	Glutamate receptor 2	GRIA2	0.0063
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0062
4226	Uridine phosphorylase 2	UPP2	0.0061
6218	Pannexin-1	PANX1	0.0061
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0061
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0061
758	Thyroid hormone receptor alpha	THRA	0.0061
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0061
5300	Antigen peptide transporter 1	TAP1	0.0061
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
1541	Metalloproteinase	mmp20	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
1196	Complement decay-accelerating factor	CD55	0.0059
1353	DNA topoisomerase 1	TOP1	0.0059
3552	DNA topoisomerase 1	topA	0.0059
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0059
444	Alcohol dehydrogenase 1B	ADH1B	0.0059
1039	Histone deacetylase 9	HDAC9	0.0059
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0058
666	NADP-dependent malic enzyme	ME1	0.0058
3382	Glycolipid transfer protein	GLTP	0.0058
362	Melatonin receptor type 1B	MTNR1B	0.0058
571	Melatonin receptor type 1A	MTNR1A	0.0058
106	Cannabinoid receptor 2	CNR2	0.0058
6131	Carbonic anhydrase 14	CA14	0.0058
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0058
707	72 kDa type IV collagenase	MMP2	0.0057
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0057
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
6146	High affinity copper uptake protein 1	SLC31A1	0.0056
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0056
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0056
4225	Uridine phosphorylase 1	UPP1	0.0056
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0056
5924	Microtubule-associated protein 4	MAP4	0.0056
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0056
5923	Microtubule-associated protein tau	MAPT	0.0056
68	Cannabinoid receptor 1	CNR1	0.0055
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0055
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0055
346	Thyroid hormone receptor beta-1	THRB	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
828	Phenylalanine-4-hydroxylase	PAH	0.0054
3109	Phenylalanine-4-hydroxylase	phhA	0.0054
6167	Organic solute transporter subunit beta	OSTB	0.0054
6166	Organic solute transporter subunit alpha	OSTA	0.0054
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0054
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0054
4403	Protein iolS	iolS	0.0054
5330	General stress protein 69	yhdN	0.0054
5322	Oxidoreductase ydhF	ydhF	0.0054
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0054
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0054
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0054
5332	MtdA bifunctional protein	mtdA	0.0054
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0054
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0054
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0054
1313	Lactoylglutathione lyase	GLO1	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0053
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0053
293	Gamma-glutamyl hydrolase	GGH	0.0053
413	Amidophosphoribosyltransferase	PPAT	0.0053
2515	Amidophosphoribosyltransferase	purF	0.0053
3714	Amidophosphoribosyltransferase	purF	0.0053
162	Retinoic acid receptor gamma-1	RARG	0.0053
5294	Nucleoside diphosphate kinase A	NME1	0.0053
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0053
94	5-hydroxytryptamine 4 receptor	HTR4	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0053
3426	Glutamine synthetase	glnA	0.0053
3987	Glutamine synthetase	GLUL	0.0053
2539	Tubulin alpha-1 chain	TUBA4A	0.0052
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0052
1792	Tissue-type plasminogen activator	PLAT	0.0052
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
908	Glutathione S-transferase theta-1	GSTT1	0.0052
291	Nitric-oxide synthase, endothelial	NOS3	0.0052
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0052
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0052
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0052
780	Retinoic acid receptor RXR-gamma	RXRG	0.0052
2808	Chloramphenicol acetyltransferase 3	cat3	0.0052
6138	Multidrug resistance protein 3	ABCB4	0.0052
494	Caspase-1	CASP1	0.0051
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
474	Acetylcholinesterase	ACHE	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
3809	Estrogen-related receptor gamma	ESRRG	0.0051
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
319	Opioid receptor, sigma 1	OPRS1	0.005
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.005
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.005
232	Corticosteroid-binding globulin	SERPINA6	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0049
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
2236	Casein kinase II subunit alpha	CSNK2A1	0.0049
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
6174	50S ribosomal protein L32	rpmF	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
2207	Rhodopsin	RHO	0.0048
518	Peroxidase/catalase T	katG	0.0048
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0048
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0048
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0048
5787	Angiopoietin-1 receptor	TEK	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
6677	Myelin P2 protein	PMP2	0.0047
2417	Chloramphenicol acetyltransferase	cat	0.0047
3278	Chloramphenicol acetyltransferase	cat	0.0047
378	Alpha-2C adrenergic receptor	ADRA2C	0.0047
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0047
2810	Dr hemagglutinin structural subunit	draA	0.0047
5073	Ferredoxin--NADP reductase	petH	0.0047
5076	Ferredoxin--NADP reductase	fpr	0.0047
5119	Ferredoxin--NADP reductase	petH	0.0047
5121	Ferredoxin--NADP reductase	fpr	0.0047
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0047
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0046
1992	Vitamin D-binding protein	GC	0.0046
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0046
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0046
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0046
5328	Prostaglandin F synthase	Tb11.02.2310	0.0046
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0046
4582	Putative pteridine reductase 2	ptr2	0.0046
2286	Isocitrate dehydrogenase [NADP]	icd	0.0046
2302	Isocitrate dehydrogenase [NADP]	icd	0.0046
2771	Isocitrate dehydrogenase [NADP]	icd	0.0046
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0046
989	L-xylulose reductase	DCXR	0.0046
3446	NADP-dependent alcohol dehydrogenase	adh	0.0046
2636	Shikimate dehydrogenase	aroE	0.0046
3515	Shikimate dehydrogenase	aroE	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0045
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
432	D(4) dopamine receptor	DRD4	0.0044
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0043
268	Adenosine A2b receptor	ADORA2B	0.0043
2077	Caspase-3	CASP3	0.0043
4210	Toll-like receptor 4	TLR4	0.0043
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.0043
199	Monocarboxylate transporter 8	SLC16A2	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
4531	Putative ketoacyl reductase	actIII	0.0042
6297	Prostaglandin reductase 1	PTGR1	0.0042
3062	Aspartate-semialdehyde dehydrogenase	asd	0.0042
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0042
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0042
239	Coagulation factor X	F10	0.0042
6432	Transporter	snf	0.0042
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0042
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0041
408	Riboflavin kinase	RFK	0.0041
4192	DNA topoisomerase 2-beta	TOP2B	0.0041
1517	Beta-3 adrenergic receptor	ADRB3	0.0041
2675	Pteridine reductase 1	PTR1	0.0041
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
1124	Sepiapterin reductase	SPR	0.004
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.004
1291	cAMP response element-binding protein	CREB1	0.004
5818	Folate receptor alpha	FOLR1	0.004
5934	Cytochrome P450 26A1	CYP26A1	0.0039
1198	Serum paraoxonase/arylesterase 1	PON1	0.0039
6223	Penicillin-binding protein 1C	pbpC	0.0039
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0038
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0038
76	Nitric-oxide synthase, brain	NOS1	0.0038
3957	Adenosine deaminase	ADA	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
768	FK506-binding protein 1A	FKBP1A	0.0037
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
6122	Carbonic anhydrase 3	CA3	0.0037
6501	Fatty acid-binding protein, liver	FABP1	0.0037
1864	RET proto-oncogene	RET	0.0037
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0036
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0036
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0036
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0036
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0036
3007	Carbonic anhydrase 12	CA12	0.0036
4205	Carbonic anhydrase 9	CA9	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
165	FL cytokine receptor	FLT3	0.0036
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
469	Annexin A1	ANXA1	0.0035
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0035
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0035
54	Prothrombin	F2	0.0035
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0034
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0034
517	Alcohol dehydrogenase 1C	ADH1C	0.0034
284	DNA-directed RNA polymerase beta chain	rpoB	0.0034
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0034
4311	tRNA	TRDMT1	0.0033
4325	tRNA	trmD	0.0033
4328	tRNA	trmD	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
976	Platelet glycoprotein IX	GP9	0.0032
1630	Integrin beta-2	ITGB2	0.0032
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
1525	Heparin-binding growth factor 2	FGF2	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0031
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.003
3856	Fibroblast growth factor receptor 3	FGFR3	0.003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.003
84	Nuclear receptor 0B1	NR0B1	0.003
283	SEC14-like protein 2	SEC14L2	0.003
3587	Gastrotropin	FABP6	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
683	Potassium transporter	GK0582	0.0029
1374	Natriuretic peptides B	NPPB	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
1827	Gap junction alpha-1 protein	GJA1	0.0029
1908	Vascular cell adhesion protein 1	VCAM1	0.0029
581	Cytochrome P450 2R1	CYP2R1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0028
174	Sigma 1-type opioid receptor	SIGMAR1	0.0028
2112	Toll-like receptor 9	TLR9	0.0028
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0027
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0027
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1025	Aquaporin-1	AQP1	0.0027
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0027
1405	Thiopurine S-methyltransferase	TPMT	0.0027
702	UMP-CMP kinase	CMPK1	0.0027
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0027
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0027
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0027
251	Alcohol dehydrogenase 1A	ADH1A	0.0027
163	D(1B) dopamine receptor	DRD5	0.0026
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0026
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0026
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0026
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0026
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0026
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0026
6044	Serum paraoxonase/lactonase 3	PON3	0.0026
153	Dopamine beta-hydroxylase	DBH	0.0026
569	Retinal dehydrogenase 2	ALDH1A2	0.0026
992	Protein tyrosine kinase 2 beta	PTK2B	0.0026
85	Growth hormone receptor	GHR	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6151	Monocarboxylate transporter 10	SLC16A10	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0025
611	Retinal dehydrogenase 1	ALDH1A1	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0024
3814	Complement C1r subcomponent	C1R	0.0024
572	Integrin alpha-L	ITGAL	0.0024
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
936	Ephrin type-A receptor 2	EPHA2	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
5798	Mitogen-activated protein kinase 11	MAPK11	0.0024
3611	Cytidine deaminase	cdd	0.0024
3707	Cytidine deaminase	cdd	0.0024
4211	Cytidine deaminase	CDA	0.0024
6231	Pepsin A	PGA3	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
2599	Tyrosine-protein kinase HCK	HCK	0.0023
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0023
6824	Tyrosine-protein kinase Lyn	LYN	0.0023
3937	Fatty-acid amide hydrolase	FAAH	0.0023
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0023
563	Thyroid peroxidase	TPO	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
814	Ryanodine receptor 1	RYR1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
2391	Ferrochelatase	hemH	0.0022
6502	Ferrochelatase	DKFZp686P18130	0.0022
1591	Ferrochelatase, mitochondrial	FECH	0.0022
3086	Plasmepsin-2	Not Available	0.0022
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0021
1262	Corticotropin-lipotropin	POMC	0.0021
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0021
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
164	Histamine H4 receptor	HRH4	0.0021
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3913	Glutamic acid decarboxylase	GAD65	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6048	Troponin C, skeletal muscle	TNNC2	0.002
564	Cellular retinoic acid-binding protein 1	CRABP1	0.002
856	Vitamin D3 receptor	VDR	0.002
6755	Poliovirus receptor	PVR	0.002
5251	Carbonyl reductase [NADPH] 1	CBR1	0.002
6163	Copper-transporting ATPase 2	ATP7B	0.002
6165	Copper-transporting ATPase 1	ATP7A	0.002
810	Heme oxygenase 1	HMOX1	0.002
3391	Heme oxygenase 1	pbsA1	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0019
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0019
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0019
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0019
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0019
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0019
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0019
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0019
1483	Membrane copper amine oxidase	AOC3	0.0019
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0019
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0019
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0019
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0019
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0019
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0019
6558	Cytochrome c oxidase subunit 1	ctaD	0.0019
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0019
6559	Cytochrome c oxidase subunit 2	ctaC	0.0019
6669	Cytochrome c oxidase subunit 2	ctaC	0.0019
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
267	Plasminogen activator inhibitor 1	SERPINE1	0.0019
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0019
1253	Interferon gamma	IFNG	0.0018
3221	Cytochrome c4	cc4	0.0018
816	Biliverdin reductase A	BLVRA	0.0018
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0018
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0018
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0018
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0018
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0018
4948	Cytochrome c-553	Not Available	0.0017
4923	Cytochrome c3	DvMF_2499	0.0017
4945	Cytochrome c3	Not Available	0.0017
4949	Cytochrome c3	DVU_3171	0.0017
4968	Cytochrome c3	cytc3	0.0017
4997	Cytochrome c3	SO_2727	0.0017
5219	Cytochrome c3	cyd	0.0017
3189	High-molecular-weight cytochrome c	hmcA	0.0017
4902	Nine-heme cytochrome c	Ddes_2038	0.0017
2540	Choloylglycine hydrolase	cbh	0.0017
735	Alanine aminotransferase 1	GPT	0.0017
3904	Alanine aminotransferase 2	GPT2	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0017
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0017
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0017
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0017
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0017
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0017
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0017
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0017
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0017
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0017
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0017
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0017
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0017
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0017
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0017
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0017
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0017
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0017
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0017
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0017
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0017
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0017
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0017
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0017
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0017
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0017
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0017
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0017
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0017
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0017
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0017
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0017
644	Heme oxygenase 2	HMOX2	0.0017
4982	Heme oxygenase 2	pbsA2	0.0017
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0017
729	GDP-L-fucose synthetase	TSTA3	0.0017
3463	GDP-L-fucose synthetase	fcl	0.0017
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0017
167	L-lactate dehydrogenase C chain	LDHC	0.0017
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0017
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0017
206	3-keto-steroid reductase	HSD17B7	0.0017
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0017
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0017
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0017
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0017
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0017
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0017
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0017
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0017
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0017
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0017
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0017
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0017
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0017
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0017
711	UDP-glucose 6-dehydrogenase	UGDH	0.0017
3672	UDP-glucose 6-dehydrogenase	hasB	0.0017
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0017
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0017
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0017
107	C-4 methylsterol oxidase	SC4MOL	0.0017
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0017
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0017
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0017
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0017
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0017
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0017
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0017
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0017
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0017
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0017
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0017
643	Peroxisomal bifunctional enzyme	EHHADH	0.0017
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0017
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0017
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0017
34	7-dehydrocholesterol reductase	DHCR7	0.0017
3830	Calreticulin	CALR	0.0017
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0017
6221	Steroid hormone receptor ERR1	ESRRA	0.0017
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0017
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0017
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0017
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0016
328	Sorbitol dehydrogenase	SORD	0.0016
597	Dihydropteridine reductase	QDPR	0.0016
396	Alcohol dehydrogenase 4	ADH4	0.0016
896	Glutathione S-transferase Mu 1	GSTM1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
857	Malate dehydrogenase, mitochondrial	MDH2	0.0016
2408	Tyrosine-protein kinase SYK	SYK	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0016
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
77	L-lactate dehydrogenase B chain	LDHB	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
4943	Cytochrome c6	petJ	0.0015
4954	Soluble cytochrome b558	Not Available	0.0015
4947	Bacterial hemoglobin	vhb	0.0015
4934	Cytochrome c-551	nirM	0.0015
5218	Cytochrome c-551	nirM	0.0015
4905	Cytochrome c2	Not Available	0.0015
4939	Cytochrome c2	cycA	0.0015
4964	Cytochrome c2	cycA	0.0015
4979	Cytochrome c2	cycA	0.0015
6673	Cytochrome c2	cycA	0.0015
4916	Cyanoglobin	glbN	0.0015
4984	Neuroglobin	NGB	0.0015
4925	Cytochrome c-type protein SHP	shp	0.0015
4994	Hemoglobin-like protein HbO	glbO	0.0015
4942	Diheme cytochrome c napB	napB	0.0015
4915	Cytochrome c-550	psbV	0.0015
4959	Cytochrome c-550	psbV	0.0015
5216	Cytochrome c-550	psbV	0.0015
4975	Cytochrome c-556	RPA3973	0.0015
4998	Hemoglobin-like protein yjbI	yjbI	0.0015
4936	Cytochrome c2 iso-2	Not Available	0.0015
4961	Hemophore HasA	hasA	0.0015
5000	HemO	hemO	0.0015
4981	Iron-starvation protein PigA	pigA	0.0015
4910	Cytoglobin	CYGB	0.0015
4909	CooA protein	cooA	0.0015
12	Alcohol dehydrogenase class 3	ADH5	0.0015
4904	Cytochrome c family protein	GSU1996	0.0015
4935	Cytochrome c-554	cycA1	0.0015
4907	Cytochrome c-L	moxG	0.0015
6865	Cytochrome c-L	moxG	0.0015
4971	Nonaheme cytochrome c	hmcA	0.0015
4976	Apocytochrome f	petA	0.0015
6407	Apocytochrome f	petA	0.0015
4937	Cytochrome oxidase subunit II	rcoxA	0.0015
4989	Cytochrome c551 peroxidase	ccp	0.0015
5222	Cytochrome c551 peroxidase	ccpA	0.0015
4764	Cytochrome P450 165C4	CYP165C4	0.0015
4999	Cytochrome P450 165B3	CYP165B3	0.0015
4931	Cytochrome P450 167A1	CYP167A1	0.0015
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0015
4960	Putative cytochrome P450-family protein	SCO7417	0.0015
4972	P450cin	cinA	0.0015
4903	Methyl-accepting chemotaxis protein	Tar4	0.0015
4922	Cytochrome c, putative	SO_4144	0.0015
4993	Hydroxylamine oxidoreductase	hao1	0.0015
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0015
4952	Catalase/peroxidase	katA	0.0015
3093	Catalase HPII	katE	0.0015
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0015
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0015
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0015
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0015
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0015
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0015
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0015
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0015
751	Potassium channel subfamily K member 6	KCNK6	0.0015
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0015
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0015
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0015
473	L-lactate dehydrogenase A chain	LDHA	0.0015
4386	Hemoglobin-like protein HbN	glbN	0.0015
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0015
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6026	Alcohol dehydrogenase 6	ADH6	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
233	Potassium channel subfamily K member 2	KCNK2	0.0014
13	Aminomethyltransferase, mitochondrial	AMT	0.0014
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0014
172	Potassium channel subfamily K member 1	KCNK1	0.0014
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0014
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0014
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0014
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0014
626	Cysteine dioxygenase type 1	CDO1	0.0014
627	11-cis retinol dehydrogenase	RDH5	0.0014
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0014
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0014
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0014
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0014
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0013
1268	Neuropeptide S receptor	NPSR1	0.0013
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0013
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0013
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
820	Glycine receptor subunit alpha-2	GLRA2	0.0013
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0013
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0013
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
694	Matrix protein 2	M	0.0012
6073	Potassium channel subfamily K member 9	KCNK9	0.0012
6072	Potassium channel subfamily K member 3	KCNK3	0.0012
279	Tyrosinase	TYR	0.0012
461	Glycine receptor subunit alpha-3	GLRA3	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0012
4920	Peroxidase/catalase	katG	0.0012
714	Glutathione reductase, mitochondrial	GSR	0.0011
2119	Cytochrome b5	CYB5A	0.0011
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0011
4990	PpcA	ppcA	0.0011
4037	Hypothetical protein	GPX1	0.0011
4297	Hypothetical protein	SP_1951	0.0011
4521	Hypothetical protein	BC_2969	0.0011
4540	Hypothetical protein	TM_1070	0.0011
4555	Hypothetical protein	MT1739	0.0011
4569	Hypothetical protein	mshD	0.0011
4578	Hypothetical protein	PA3270	0.0011
4747	Hypothetical protein	PA3967	0.0011
5177	Hypothetical protein	TM_0096	0.0011
5194	Hypothetical protein	PA1204	0.0011
5240	Hypothetical protein	Rv2991	0.0011
5370	Hypothetical protein	TM_1158	0.0011
5710	Hypothetical protein	Tb927.5.1360	0.0011
4289	Cytochrome P450	TT_P0059	0.0011
6262	Cytochrome P450	staP	0.0011
3570	Cytochrome P450 152A1	cypC	0.0011
4988	Sulfite oxidase, mitochondrial	SUOX	0.0011
4992	Cytochrome c peroxidase	Not Available	0.0011
760	Fibroblast growth factor 1	FGF1	0.0011
3375	Acidic cytochrome c3	Not Available	0.0011
2915	Sensor protein fixL	fixL	0.0011
4944	Sensor protein fixL	fixL	0.0011
4385	Cytochrome c'	Not Available	0.0011
4967	Cytochrome c'	cycA	0.0011
5038	Cytochrome c'	Not Available	0.0011
5223	Cytochrome c'	cycP	0.0011
4813	Heme oxygenase	hmuO	0.0011
5769	Heme oxygenase	Not Available	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
2230	Catalase	CAT	0.0011
3249	Catalase	katA	0.0011
3625	Catalase	katA	0.0011
4539	Catalase	katA	0.0011
4941	Catalase	katB	0.0011
131	Synaptic vesicular amine transporter	SLC18A2	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
997	Protein kinase C beta type	PRKCB	0.001
3670	Soluble cytochrome b562 precursor	cybC	0.001
3411	Cytochrome P450 121	cyp121	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
2617	Nitric oxide synthase oxygenase	nos	0.001
2701	Nitric oxide synthase oxygenase	nos	0.001
3291	Cytochrome c-552	cycA	0.001
4927	Cytochrome c-552	nrfA	0.001
4938	Cytochrome c-552	cycA	0.001
4953	Cytochrome c-552	nrfA	0.001
5217	Cytochrome c-552	cycM	0.001
3102	Flavohemoprotein	hmp	0.001
4969	Flavohemoprotein	hmp	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.001
890	Niemann-Pick C1-like protein 1	NPC1L1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
6228	Nuclear receptor coactivator 1	NCOA1	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0009
1569	G1/S-specific cyclin-D1	CCND1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0009
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0009
1760	Aminopeptidase N	ANPEP	0.0009
6843	Aminopeptidase N	pepN	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0009
117	Sterol O-acyltransferase 1	SOAT1	0.0008
1184	Interferon beta	IFNB1	0.0008
4608	Putative cytochrome P450	SCO1207	0.0008
4963	Putative cytochrome P450	SCO2884	0.0008
6254	Putative cytochrome P450	SCO6998	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
358	Cystathionine beta-synthase	CBS	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
693	Hemoglobin subunit beta	HBB	0.0008
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0007
6268	Hydroxyacid oxidase 1	HAO1	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
4692	A/G-specific adenine glycosylase	mutY	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
2298	Cytochrome P450-cam	camC	0.0006
2802	Endoglucanase G	celCCG	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
1176	Mitogen-activated protein kinase 1	MAPK1	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2430	Chondroitinase B	cslB	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
6021	Adenosine kinase	ADK	0.0002
2440	Endoglucanase F	celCCF	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00945 - Acetylsalicylic acid

Targets

Enzymes

Transporters

Carriers

Predictions