DT-Web: DB00703

Identification

Name

Methazolamide

Accession Number

DB00703 (APRD00740)

Type

small molecule

Description

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

236.272

Groups

approved

Monoisotopic Weight

236.003781522

Pharmacology

Indication

For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma

Mechanism of action

Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

Absorption

Methazolamide is well absorbed from the gastrointestinal tract.

Protein binding

55%

Biotransformation

Not Available

Route of elimination

Not Available

Toxicity

Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetylsalicylic acid	Acetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Bismuth Subsalicylate	The salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Brinzolamide	As both brinzolamide and methazolamide are carbonic anhydrase inhibitors, there is an increased risk of adverse effects.The development of acid-base disorders with concurrent use of ophthalmic and oral carbonic anhydrase inhibitors has been reported. Avoid concurrent use of different carbonic anhydrase inhibitors when possible.
Magnesium salicylate	The salicylate, magnesium salicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Memantine	Possible increased levels of memantine
Salicylate-sodium	The salicylate, salicylate-sodium, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Salsalate	The salicylate, salsalate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Trisalicylate-choline	The salicylate, trisalicylate-choline, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.

Food Interactions

Take with food, more than 6 hours before bedtime increase liquid intake.

Carbonic anhydrase 1
Name	Carbonic anhydrase 1
Gene Name	CA1
Pharmacological action	yes
Actions	inhibitor
References	Ilies MA, Masereel B, Rolin S, Scozzafava A, Campeanu G, Cimpeanu V, Supuran CT: Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity. Bioorg Med Chem. 2004 May 15;12(10):2717-26. - Pubmed Winum JY, Casini A, Mincione F, Starnotti M, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. Bioorg Med Chem Lett. 2004 Jan 5;14(1):225-9. - Pubmed Iyer GR, Bellantone RA, Taft DR: In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics. J Pharmacokinet Biopharm. 1999 Feb;27(1):45-66. - Pubmed Scozzafava A, Briganti F, Ilies MA, Supuran CT: Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes. J Med Chem. 2000 Jan 27;43(2):292-300. - Pubmed Lindskog S: Structure and mechanism of carbonic anhydrase. Pharmacol Ther. 1997;74(1):1-20. - Pubmed
DTHybrid score	0.7449
Carbonic anhydrase 2
Name	Carbonic anhydrase 2
Gene Name	CA2
Pharmacological action	yes
Actions	inhibitor
References	Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	1.7897
Carbonic anhydrase 4
Name	Carbonic anhydrase 4
Gene Name	CA4
Pharmacological action	yes
Actions	inhibitor
References	Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	0.5517
Carbonic anhydrase 7
Name	Carbonic anhydrase 7
Gene Name	CA7
Pharmacological action	yes
Actions	inhibitor
References	Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	0.3112

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4029
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4863
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4391
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2994
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6092

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. - Pubmed
DTHybrid score	0.4002

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.2343
4924	Cytochrome P450 2C8	CYP2C8	0.2116
1588	Multidrug resistance protein 1	ABCB1	0.184
4118	Cytochrome P450 3A5	CYP3A5	0.1602
6030	Cytochrome P450 2B6	CYP2B6	0.1472
466	Solute carrier family 12 member 3	SLC12A3	0.146
6107	Cytochrome P450 3A7	CYP3A7	0.1183
3007	Carbonic anhydrase 12	CA12	0.1133
4205	Carbonic anhydrase 9	CA9	0.1131
558	Solute carrier family 12 member 1	SLC12A1	0.1066
6024	Cytochrome P450 1A1	CYP1A1	0.1061
20	Prostaglandin G/H synthase 1	PTGS1	0.1019
5718	Cytochrome P450 2A6	CYP2A6	0.101
587	Serum albumin	ALB	0.0967
6131	Carbonic anhydrase 14	CA14	0.0914
6122	Carbonic anhydrase 3	CA3	0.0878
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0863
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0856
6142	Solute carrier family 22 member 8	SLC22A8	0.0756
492	Histamine H1 receptor	HRH1	0.0685
1024	Solute carrier family 22 member 11	SLC22A11	0.0662
290	Prostaglandin G/H synthase 2	PTGS2	0.0646
1025	Aquaporin-1	AQP1	0.0628
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0623
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0571
824	Sodium-dependent serotonin transporter	SLC6A4	0.0563
1405	Thiopurine S-methyltransferase	TPMT	0.0561
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0541
6106	Cytochrome P450 2C18	CYP2C18	0.05
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0491
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0468
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0456
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0455
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0444
6143	Solute carrier family 22 member 7	SLC22A7	0.0438
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0438
862	Multidrug resistance-associated protein 1	ABCC1	0.0428
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0426
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0417
6145	Solute carrier family 22 member 1	SLC22A1	0.0406
556	Alpha-1A adrenergic receptor	ADRA1A	0.0403
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0402
831	D(2) dopamine receptor	DRD2	0.0401
118	Organic cation/carnitine transporter 2	SLC22A5	0.0396
3811	Cytochrome P450 19A1	CYP19A1	0.0387
103	Muscarinic acetylcholine receptor M1	CHRM1	0.038
6144	Solute carrier family 22 member 2	SLC22A2	0.0358
2164	Multidrug resistance-associated protein 4	ABCC4	0.0333
3941	Amine oxidase [flavin-containing] A	MAOA	0.0333
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0333
766	Beta-2 adrenergic receptor	ADRB2	0.0328
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0325
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0318
713	Sodium-dependent dopamine transporter	SLC6A3	0.0311
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.031
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0305
776	Bile salt export pump	ABCB11	0.0297
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0297
260	Cytochrome P450 51	ERG11	0.0296
761	Cytochrome P450 51	ERG11	0.0296
3163	Cytochrome P450 51	cyp51	0.0296
1898	Cytochrome P450 1B1	CYP1B1	0.0289
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0289
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0285
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0274
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0272
23	D(1A) dopamine receptor	DRD1	0.0272
318	Alpha-2A adrenergic receptor	ADRA2A	0.0271
731	HIV-1 protease	HIV-1 protease	0.027
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0264
3939	Amine oxidase [flavin-containing] B	MAOB	0.0263
193	Beta-1 adrenergic receptor	ADRB1	0.0261
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.026
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0257
847	Mu-type opioid receptor	OPRM1	0.0255
632	Alpha-1B adrenergic receptor	ADRA1B	0.0253
634	Squalene monooxygenase	SQLE	0.0242
7196	Squalene monooxygenase	ERG1	0.0242
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0241
136	Estrogen receptor	ESR1	0.024
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.024
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0227
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0226
997	Protein kinase C beta type	PRKCB	0.0222
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0221
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0221
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0219
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0214
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0214
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0212
467	Delta-type opioid receptor	OPRD1	0.021
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0209
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0209
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0207
3623	Divalent-cation tolerance protein cutA	cutA	0.0206
310	Solute carrier family 12 member 2	SLC12A2	0.0206
1970	Protein kinase C alpha type	PRKCA	0.0204
833	Organic cation/carnitine transporter 1	SLC22A4	0.0204
6031	Cytochrome P450 3A43	CYP3A43	0.0203
2408	Tyrosine-protein kinase SYK	SYK	0.0202
871	Glucocorticoid receptor	NR3C1	0.0201
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0195
696	Kappa-type opioid receptor	OPRK1	0.0195
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0195
817	DNA topoisomerase 2-alpha	TOP2A	0.0191
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.019
465	Calmodulin	CALM1	0.0189
633	Penicillin-binding proteins 1A/1B	pbpA	0.0185
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0184
6147	Solute carrier family 22 member 3	SLC22A3	0.0183
891	Dihydropteroate synthase	folP	0.0182
5359	Dihydropteroate synthase	folP	0.0182
7175	Dihydropteroate synthase	sulI	0.0182
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0179
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0179
468	Cytochrome P450 4A11	CYP4A11	0.0178
638	D(3) dopamine receptor	DRD3	0.0178
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0177
122	P2Y purinoceptor 12	P2RY12	0.017
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0169
6127	Carbonic anhydrase-related protein	CA8	0.0168
6129	Carbonic anhydrase-related protein 11	CA11	0.0168
6128	Carbonic anhydrase-related protein 10	CA10	0.0167
6135	Sodium channel subunit beta-4	SCN4B	0.0167
6133	Sodium channel subunit beta-2	SCN2B	0.0167
6132	Sodium channel subunit beta-1	SCN1B	0.0167
6134	Sodium channel subunit beta-3	SCN3B	0.0167
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0166
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0165
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0164
789	Alpha-1D adrenergic receptor	ADRA1D	0.0164
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0163
2236	Casein kinase II subunit alpha	CSNK2A1	0.016
404	DNA gyrase subunit A	gyrA	0.0158
6224	DNA gyrase subunit A	gyrA	0.0158
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0157
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0157
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0157
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0156
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0153
3426	Glutamine synthetase	glnA	0.0151
3987	Glutamine synthetase	GLUL	0.0151
6130	Carbonic anhydrase 13	CA13	0.015
146	Androgen receptor	AR	0.0148
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0147
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0141
629	Alpha-2B adrenergic receptor	ADRA2B	0.014
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0138
6136	Multidrug resistance-associated protein 5	ABCC5	0.0137
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0137
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0136
6020	Aldehyde oxidase	AOX1	0.0136
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0135
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0135
3226	UPF0234 protein HI1034	HI_1034	0.0135
738	Monocarboxylate transporter 1	SLC16A1	0.0135
432	D(4) dopamine receptor	DRD4	0.0134
3384	Macrophage migration inhibitory factor	MIF	0.0132
3923	Cholinesterase	BCHE	0.013
723	Cytosolic phospholipase A2	PLA2G4A	0.013
70	Type-1 angiotensin II receptor	AGTR1	0.0129
338	DNA polymerase	UL30	0.0128
379	DNA polymerase	UL54	0.0128
697	DNA polymerase	ORF28	0.0128
2482	DNA polymerase	43	0.0128
4104	DNA polymerase	BALF5	0.0128
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0126
378	Alpha-2C adrenergic receptor	ADRA2C	0.0126
6102	Arylamine N-acetyltransferase 2	NAT2	0.0126
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0124
6182	Cytochrome P450 2J2	CYP2J2	0.0123
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
3639	Thymidine phosphorylase	deoA	0.0122
3936	Thymidine phosphorylase	TYMP	0.0122
373	Transthyretin	TTR	0.012
6148	Multidrug resistance-associated protein 7	ABCC10	0.012
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0118
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0118
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0118
777	Tumor necrosis factor	TNF	0.0118
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0116
482	Glycine receptor subunit alpha-1	GLRA1	0.0115
1757	Myeloperoxidase	MPO	0.0115
6141	Sodium/bile acid cotransporter	SLC10A1	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0112
811	Translocator protein	TSPO	0.0112
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0112
124	Histamine H2 receptor	HRH2	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0109
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0109
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0109
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0109
3105	M-phase inducer phosphatase 2	CDC25B	0.0108
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0108
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0108
4604	Liver carboxylesterase 1	CES1	0.0108
645	Penicillin-binding protein 1A	mrcA	0.0107
5805	Penicillin-binding protein 1A	ponA	0.0107
6185	Penicillin-binding protein 1A	mrcA	0.0107
6799	Penicillin-binding protein 1A	pbpA	0.0107
6014	Cytochrome P450 2A13	CYP2A13	0.0106
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0106
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0106
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0106
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0106
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0105
380	Cytochrome P450 17A1	CYP17A1	0.0104
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0104
94	5-hydroxytryptamine 4 receptor	HTR4	0.0104
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0103
6220	Aryl hydrocarbon receptor	AHR	0.0103
16	Adenosine A1 receptor	ADORA1	0.0101
614	Progesterone receptor	PGR	0.0101
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.01
161	Tubulin beta chain	TUBB	0.01
312	Tubulin beta chain	TUB2	0.01
140	30S ribosomal protein S9	rpsI	0.01
6719	30S ribosomal protein S9	rpsI	0.01
6725	30S ribosomal protein S9	rpsI	0.01
474	Acetylcholinesterase	ACHE	0.0098
49	Endothelin B receptor	EDNRB	0.0096
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0095
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0095
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0095
1010	Cytochrome P450 51A1	CYP51A1	0.0094
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0094
6137	Multidrug resistance-associated protein 6	ABCC6	0.0094
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0094
716	5-hydroxytryptamine 7 receptor	HTR7	0.0094
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0093
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0093
365	Dihydrofolate reductase	DHFR	0.0093
2381	Dihydrofolate reductase	DFR1	0.0093
2833	Dihydrofolate reductase	Not Available	0.0093
2931	Dihydrofolate reductase	folA	0.0093
3544	Dihydrofolate reductase	folA	0.0093
3682	Dihydrofolate reductase	folA	0.0093
6642	Dihydrofolate reductase	folA	0.0093
6756	Dihydrofolate reductase	dfrA	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0092
3810	Catechol O-methyltransferase	COMT	0.0092
705	Glutamate receptor 1	GRIA1	0.0092
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.009
163	D(1B) dopamine receptor	DRD5	0.0089
275	Arachidonate 5-lipoxygenase	ALOX5	0.0088
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0088
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0088
1178	Adenosine A2a receptor	ADORA2A	0.0087
183	Vascular endothelial growth factor A	VEGFA	0.0086
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0086
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0085
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0085
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0083
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0083
477	DNA topoisomerase 4 subunit A	parC	0.0083
886	DNA topoisomerase 4 subunit A	parC	0.0083
6226	DNA topoisomerase 4 subunit A	parC	0.0083
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0082
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0081
22	30S ribosomal protein S4	rpsD	0.0081
6714	30S ribosomal protein S4	rpsD	0.0081
3932	Glutathione S-transferase A2	GSTA2	0.0081
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.008
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0079
65	Matrix metalloproteinase-9	Not Available	0.0078
844	Epidermal growth factor receptor	EGFR	0.0077
543	Penicillin-binding protein 1B	mrcB	0.0077
6186	Penicillin-binding protein 1B	ponB	0.0077
6822	Penicillin-binding protein 1b	pbp1b	0.0077
6844	Penicillin-binding protein 1b	pbp1b	0.0077
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0076
3947	Xanthine dehydrogenase/oxidase	XDH	0.0076
504	Mast/stem cell growth factor receptor	KIT	0.0075
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0075
1656	CYP2B protein	CYP2B	0.0075
24	Thymidylate synthase	TMP1	0.0074
359	Thymidylate synthase	TYMS	0.0074
2626	Thymidylate synthase	thyA	0.0074
2729	Thymidylate synthase	thyA	0.0074
5352	Thymidylate synthase	THYA	0.0074
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0074
2320	Thymidine kinase, cytosolic	TK1	0.0074
407	Vascular endothelial growth factor receptor 2	KDR	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0072
818	50S ribosomal protein L10	rplJ	0.0071
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0071
4122	Histone deacetylase 2	HDAC2	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.007
3917	Methylenetetrahydrofolate reductase	MTHFR	0.007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.007
130	Prostacyclin synthase	PTGIS	0.0069
921	Glutamate receptor 2	GRIA2	0.0068
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0068
153	Dopamine beta-hydroxylase	DBH	0.0067
3627	UPF0190 protein yedY	yedY	0.0067
1392	Catenin beta-1	CTNNB1	0.0067
3352	Structural polyprotein	Not Available	0.0067
3628	Structural polyprotein	Not Available	0.0067
4892	Structural polyprotein	Not Available	0.0067
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0067
952	Dipeptidyl peptidase 4	DPP4	0.0066
6043	Putative G-protein coupled receptor 44	GPR44	0.0066
4120	NADPH--cytochrome P450 reductase	POR	0.0066
29	Tubulin beta-1 chain	TUBB1	0.0066
527	Prostacyclin receptor	PTGIR	0.0066
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0065
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0064
869	Estrogen receptor beta	ESR2	0.0063
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0063
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0063
133	Dihydropterate synthase	sulI	0.0063
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0062
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0062
1275	Estrogen sulfotransferase	SULT1E1	0.0062
518	Peroxidase/catalase T	katG	0.0061
756	Sex hormone-binding globulin	SHBG	0.0061
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0061
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.006
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.006
5626	Nucleoside diphosphate kinase B	NME2	0.006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0059
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0059
444	Alcohol dehydrogenase 1B	ADH1B	0.0059
251	Alcohol dehydrogenase 1A	ADH1A	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
427	Substance-P receptor	TACR1	0.0058
814	Ryanodine receptor 1	RYR1	0.0058
26	Vascular endothelial growth factor receptor 3	FLT4	0.0057
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0057
563	Thyroid peroxidase	TPO	0.0056
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0055
32	Vascular endothelial growth factor receptor 1	FLT1	0.0055
6506	Stathmin-4	STMN4	0.0055
1192	Sulfotransferase 1A1	SULT1A1	0.0055
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0054
1050	Bile salt sulfotransferase	SULT2A1	0.0054
823	Fibroblast growth factor receptor 2	FGFR2	0.0054
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0053
856	Vitamin D3 receptor	VDR	0.0053
6149	Solute carrier family 22 member 10	SLC22A10	0.0052
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0052
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
1196	Complement decay-accelerating factor	CD55	0.0051
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.005
4773	Deoxycytidine kinase	DCK	0.0049
244	Angiotensin-converting enzyme	ACE	0.0049
3404	Exotoxin A	eta	0.0049
174	Sigma 1-type opioid receptor	SIGMAR1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
5294	Nucleoside diphosphate kinase A	NME1	0.0048
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0048
6432	Transporter	snf	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
6085	Fatty acid-binding protein, intestinal	FABP2	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
1483	Membrane copper amine oxidase	AOC3	0.0046
1253	Interferon gamma	IFNG	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0045
904	Glutathione S-transferase P	GSTP1	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
517	Alcohol dehydrogenase 1C	ADH1C	0.0045
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
2230	Catalase	CAT	0.0044
3249	Catalase	katA	0.0044
3625	Catalase	katA	0.0044
4539	Catalase	katA	0.0044
4941	Catalase	katB	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
2808	Chloramphenicol acetyltransferase 3	cat3	0.0044
1618	High affinity nerve growth factor receptor	NTRK1	0.0044
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0044
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0044
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0044
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0044
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
284	DNA-directed RNA polymerase beta chain	rpoB	0.0043
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0043
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
293	Gamma-glutamyl hydrolase	GGH	0.0042
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0042
54	Prothrombin	F2	0.0042
115	Penicillin-binding protein 2	mrdA	0.0041
6069	Penicillin-binding protein 2	mrdA	0.0041
6118	Penicillin-binding protein 2	penA	0.0041
6187	Penicillin-binding protein 2	pbpA	0.0041
6686	Penicillin-binding protein 2	pbp2	0.0041
6939	Penicillin-binding protein 2	mrdA	0.0041
7163	Penicillin-binding protein 2	pbpA	0.0041
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
1629	Transcription factor AP-1	JUN	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0041
408	Riboflavin kinase	RFK	0.0041
319	Opioid receptor, sigma 1	OPRS1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
718	Folate receptor gamma	FOLR3	0.004
299	Folate receptor beta	FOLR2	0.004
2417	Chloramphenicol acetyltransferase	cat	0.004
3278	Chloramphenicol acetyltransferase	cat	0.004
804	Mitochondrial folate transporter/carrier	SLC25A32	0.004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.004
3937	Fatty-acid amide hydrolase	FAAH	0.004
737	Mineralocorticoid receptor	NR3C2	0.004
2810	Dr hemagglutinin structural subunit	draA	0.004
315	Arginase-1	ARG1	0.004
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.004
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0039
581	Cytochrome P450 2R1	CYP2R1	0.0039
1541	Metalloproteinase	mmp20	0.0039
3808	Dihydropteroate synthase 2	folP2	0.0039
3601	Dihydropteroate synthase 1	folP1	0.0039
3807	Dihydropteroate synthase 1	folP1	0.0039
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0039
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
976	Platelet glycoprotein IX	GP9	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4311	tRNA	TRDMT1	0.0039
4325	tRNA	trmD	0.0039
4328	tRNA	trmD	0.0039
1	Peptidoglycan synthetase ftsI	ftsI	0.0038
4155	Peptidoglycan synthetase ftsI	ftsI	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0038
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0038
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0038
85	Growth hormone receptor	GHR	0.0038
1650	Heme carrier protein 1	SLC46A1	0.0037
5353	Glutamate decarboxylase alpha	gadA	0.0037
164	Histamine H4 receptor	HRH4	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
6146	High affinity copper uptake protein 1	SLC31A1	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
1867	Major prion protein	PRNP	0.0036
707	72 kDa type IV collagenase	MMP2	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0035
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0035
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0035
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
3809	Estrogen-related receptor gamma	ESRRG	0.0034
780	Retinoic acid receptor RXR-gamma	RXRG	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0033
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
4217	Telomerase reverse transcriptase	TERT	0.0033
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0032
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0032
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0032
6033	High affinity interleukin-8 receptor A	CXCR1	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
239	Coagulation factor X	F10	0.0031
7	Nitric oxide synthase, inducible	NOS2	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
6207	30S ribosomal protein S14	rpsN	0.0031
6209	30S ribosomal protein S19	rpsS	0.0031
6712	30S ribosomal protein S19	rpsS	0.0031
6726	30S ribosomal protein S19	rpsS	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
1517	Beta-3 adrenergic receptor	ADRB3	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
3868	Calcineurin subunit B isoform 2	PPP3R2	0.003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.003
88	Retinoic acid receptor RXR-beta	RXRB	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
106	Cannabinoid receptor 2	CNR2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.003
84	Nuclear receptor 0B1	NR0B1	0.003
1374	Natriuretic peptides B	NPPB	0.003
1827	Gap junction alpha-1 protein	GJA1	0.003
1908	Vascular cell adhesion protein 1	VCAM1	0.003
6174	50S ribosomal protein L32	rpmF	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.003
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0029
654	Flavin reductase	BLVRB	0.0029
3913	Glutamic acid decarboxylase	GAD65	0.0029
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
6167	Organic solute transporter subunit beta	OSTB	0.0028
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
6166	Organic solute transporter subunit alpha	OSTA	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
2298	Cytochrome P450-cam	camC	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1992	Vitamin D-binding protein	GC	0.0028
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0027
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
273	Apoptosis regulator Bcl-2	BCL2	0.0027
3685	Catabolite gene activator	crp	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0026
165	FL cytokine receptor	FLT3	0.0026
1630	Integrin beta-2	ITGB2	0.0026
4103	Proteasome subunit beta type 2	PSMB2	0.0026
4102	Proteasome subunit beta type 5	PSMB5	0.0026
4101	Proteasome subunit beta type 1	PSMB1	0.0026
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0025
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0025
268	Adenosine A2b receptor	ADORA2B	0.0025
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
469	Annexin A1	ANXA1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0025
1648	Elastin	ELN	0.0024
735	Alanine aminotransferase 1	GPT	0.0024
3904	Alanine aminotransferase 2	GPT2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
1714	Mitogen-activated protein kinase 3	MAPK3	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
358	Cystathionine beta-synthase	CBS	0.0024
5787	Angiopoietin-1 receptor	TEK	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
2021	Thrombomodulin	THBD	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
908	Glutathione S-transferase theta-1	GSTT1	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0023
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0023
3086	Plasmepsin-2	Not Available	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
4760	Mll3241 protein	mll3241	0.0023
6218	Pannexin-1	PANX1	0.0022
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
1039	Histone deacetylase 9	HDAC9	0.0022
33	Cystine/glutamate transporter	SLC7A11	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
6044	Serum paraoxonase/lactonase 3	PON3	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
1198	Serum paraoxonase/arylesterase 1	PON1	0.0021
6223	Penicillin-binding protein 1C	pbpC	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
132	ATP-binding cassette sub-family A member 1	ABCA1	0.002
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
1360	Sphingomyelin phosphodiesterase	SMPD1	0.002
1507	Cytochrome c	CYCS	0.002
751	Potassium channel subfamily K member 6	KCNK6	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
572	Integrin alpha-L	ITGAL	0.002
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
867	Penicillin-binding protein 3	pbpC	0.0019
6119	Penicillin-binding protein 3	pbp3	0.0019
7154	Penicillin-binding protein 3	pbp3	0.0019
7157	Penicillin-binding protein 3	LMHCC_2184	0.0019
7162	Penicillin-binding protein 3	pbpB	0.0019
7172	Penicillin-binding protein 3	pbp3	0.0019
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0019
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
1864	RET proto-oncogene	RET	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0019
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0019
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0019
896	Glutathione S-transferase Mu 1	GSTM1	0.0019
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0018
172	Potassium channel subfamily K member 1	KCNK1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
53	Solute carrier family 12 member 5	SLC12A5	0.0018
663	Solute carrier family 12 member 4	SLC12A4	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
291	Nitric-oxide synthase, endothelial	NOS3	0.0017
6042	Prostaglandin reductase 2	PTGR2	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
5934	Cytochrome P450 26A1	CYP26A1	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
3830	Calreticulin	CALR	0.0017
3957	Adenosine deaminase	ADA	0.0017
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
1792	Tissue-type plasminogen activator	PLAT	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
494	Caspase-1	CASP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
3221	Cytochrome c4	cc4	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
5798	Mitogen-activated protein kinase 11	MAPK11	0.0015
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
2207	Rhodopsin	RHO	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
267	Plasminogen activator inhibitor 1	SERPINE1	0.0014
489	Monocarboxylate transporter 2	SLC16A7	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3760	Penicillin-binding protein 5 precursor	dacA	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6163	Copper-transporting ATPase 2	ATP7B	0.0014
6165	Copper-transporting ATPase 1	ATP7A	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
822	Aldose reductase	AKR1B1	0.0014
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0013
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
6221	Steroid hormone receptor ERR1	ESRRA	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
2077	Caspase-3	CASP3	0.0013
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
500	Monocarboxylate transporter 4	SLC16A3	0.0012
819	Penicillin-binding protein 4	dacB	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
1295	Fatty acid synthase	FASN	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
702	UMP-CMP kinase	CMPK1	0.0012
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0011
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
76	Nitric-oxide synthase, brain	NOS1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
798	Osteocalcin	BGLAP	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
5818	Folate receptor alpha	FOLR1	0.0008
4037	Hypothetical protein	GPX1	0.0008
4297	Hypothetical protein	SP_1951	0.0008
4521	Hypothetical protein	BC_2969	0.0008
4540	Hypothetical protein	TM_1070	0.0008
4555	Hypothetical protein	MT1739	0.0008
4569	Hypothetical protein	mshD	0.0008
4578	Hypothetical protein	PA3270	0.0008
4747	Hypothetical protein	PA3967	0.0008
5177	Hypothetical protein	TM_0096	0.0008
5194	Hypothetical protein	PA1204	0.0008
5240	Hypothetical protein	Rv2991	0.0008
5370	Hypothetical protein	TM_1158	0.0008
5710	Hypothetical protein	Tb927.5.1360	0.0008
4527	Putative hydrolase ycdX	ycdX	0.0008
4536	Transcriptional regulator, IclR family	TM_0065	0.0008
2501	Protein ygbM	ygbM	0.0008
4545	Molybdopterin-converting factor subunit 2	moaE	0.0008
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0008
4106	Guanylate kinase	GUK1	0.0008
4516	Guanylate kinase	gmk	0.0008
4538	Hypothetical protein VC1899	VC_1899	0.0008
4529	Oxalate decarboxylase oxdC	oxdC	0.0008
4514	Citrate lyase beta subunit-like protein	citE	0.0008
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0008
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0008
4524	Mannose-6-phosphate isomerase	yvyI	0.0008
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0008
4547	Iron binding protein FbpA	fbpA	0.0008
4548	Gyrase B	gyrB	0.0008
4546	Aminotransferase, putative	TM_1131	0.0008
658	Para-aminobenzoate synthase component 1	pabB	0.0008
4515	Peripheral plasma membrane protein CASK	CASK	0.0008
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6459	Glycodelin	PAEP	0.0008
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
369	Coagulation factor VII	F7	0.0008
3587	Gastrotropin	FABP6	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
4496	C-terminal-binding protein 1	CTBP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
4517	Probable butyrate kinase 2	buk2	0.0007
3261	Signal recognition particle protein	ffh	0.0007
4528	Phenazine biosynthesis protein PhzD	phzD1	0.0007
4533	Glyoxalase family protein	BC_1747	0.0007
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0007
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3759	Glutathione S-transferase	gst	0.0007
4541	Glutathione S-transferase	GST	0.0007
4542	Glutaminase 1	glsA1	0.0007
4544	Glutaminase 1	glsA1	0.0007
2929	(S)-2-haloacid dehalogenase	dhlB	0.0007
2995	(S)-2-haloacid dehalogenase	Not Available	0.0007
3237	Beta-lactamase OXA-2	bla	0.0007
4532	Gephyrin	GPHN	0.0007
2802	Endoglucanase G	celCCG	0.0007
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
125	DNA polymerase beta	POLB	0.0007
4531	Putative ketoacyl reductase	actIII	0.0007
2775	Dihydroorotate dehydrogenase	pyrD	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
3467	Methylglyoxal synthase	mgsA	0.0007
3583	6-phosphogluconolactonase	pgl	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0006
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
2688	Peptide deformylase	def	0.0006
2708	Peptide deformylase	def	0.0006
3004	Peptide deformylase	def	0.0006
4337	Peptide deformylase	def	0.0006
4338	Peptide deformylase	def	0.0006
5368	Peptide deformylase	def	0.0006
5371	Peptide deformylase	def	0.0006
6375	Peptide deformylase	def	0.0006
6378	Peptide deformylase	def	0.0006
6379	Peptide deformylase	def	0.0006
6776	Peptide deformylase	def	0.0006
6900	Peptide deformylase	def	0.0006
4534	Cytohesin-2	CYTH2	0.0006
162	Retinoic acid receptor gamma-1	RARG	0.0006
2548	Subtilisin Carlsberg	apr	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0006
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
3027	Streptavidin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
5682	Ribonuclease pancreatic	RNASE1	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00703 - Methazolamide

Targets

Enzymes

Transporters

Predictions