DT-Web

DB01043 - Memantine


Identification
Name Memantine
Accession Number DB01043 (APRD00221)
Type small molecule
Description Memantine is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer's disease, but there has been no clinical support for the prevention or slowing of disease progression.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 179.3018
Groups approved
Monoisotopic Weight 179.167399677
Pharmacology
Indication For the treatment of moderate to severe dementia of the Alzheimer's type.
Mechanism of action Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Prolonged increased levels of glutamate in the brain of demented patients are sufficient to counter the voltage-dependent block of NMDA receptors by Mg2+ ions and allow continuous influx of Ca2+ ions into cells, ultimately resulting in neuronal degeneration. Studies suggest that memantine binds more effectively than Mg2+ ions at the NMDA receptor, and thereby effectively blocks this prolonged influx of Ca2+ ions through the NMDA channel whilst preserving the transient physiological activation of the channels by higher concentrations of synaptically released glutamate. Thus memantine protects against chronically elevated concentrations of glutamate. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for ?-aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.
Absorption Well absorbed orally with a bioavailability of approximately 100%. Peak plasma concentrations are reached in 3-7 hours. Food has no effect on absorption.
Protein binding 45%
Biotransformation Excreted largely unchanged. About 20% is metabolized to 1-amino-3-hydroxymethyl-5-methyl-adamantane and 3-amino-1-hydroxy-5,7-dimethyl-adamantane.
Route of elimination Memantine undergoes partial hepatic metabolism. About 48% of administered drug is excreted unchanged in urine; the remainder is converted primarily to three polar metabolites which possess minimal NMDA receptor antagonistic activity: the N-glucuronide conjugate, 6-hydroxy memantine, and 1-nitroso-deaminated memantine. It is excreted predominantly in the urine, unchanged.
Toxicity Side effects include pain, abnormal crying, leg pain, fever, increased apetite. Adverse drug reactions include: dizziness, confusion, headache, hallucinations, tiredness. Less common side effects include: vomiting, anxiety, hypertonia, cystitis, and increased libido. Doses of up to 400 mg have been tolerated.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetazolamide Possible increased levels of memantine
Amantadine Increased risk of CNS adverse effects with this association
Dichlorphenamide Possible increased levels of memantine
Ketamine Increased risk of CNS adverse effects with this association
Methazolamide Possible increased levels of memantine
Sodium bicarbonate Possible increased levels of memantine
Food Interactions
  • Take without regard to meals.

Targets


Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action yes
Actions antagonist
References
  • Smothers CT, Woodward JJ: Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. - Pubmed
  • Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D: Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature. 2002 Feb 14;415(6873):793-8. Epub 2002 Jan 30. - Pubmed
  • Schrattenholz A, Soskic V: NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling. Curr Top Med Chem. 2006;6(7):663-86. - Pubmed
  • Foster AC, Kemp JA: Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. Epub 2005 Dec 22. - Pubmed
  • Rogawski MA, Wenk GL: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev. 2003 Fall;9(3):275-308. - Pubmed
DTHybrid score 0.4647
Glutamate [NMDA] receptor subunit epsilon-1
Name Glutamate [NMDA] receptor subunit epsilon-1
Gene Name GRIN2A
Pharmacological action yes
Actions antagonist
References
  • Chen HS, Lipton SA: Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels. J Pharmacol Exp Ther. 2005 Sep;314(3):961-71. Epub 2005 May 18. - Pubmed
  • Maler JM, Esselmann H, Wiltfang J, Kunz N, Lewczuk P, Reulbach U, Bleich S, Ruther E, Kornhuber J: Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons. Brain Res. 2005 Aug 9;1052(2):156-62. - Pubmed
  • Bresink I, Benke TA, Collett VJ, Seal AJ, Parsons CG, Henley JM, Collingridge GL: Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Br J Pharmacol. 1996 Sep;119(2):195-204. - Pubmed
  • Blanpied TA, Boeckman FA, Aizenman E, Johnson JW: Trapping channel block of NMDA-activated responses by amantadine and memantine. J Neurophysiol. 1997 Jan;77(1):309-23. - Pubmed
  • Rogawski MA, Wenk GL: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev. 2003 Fall;9(3):275-308. - Pubmed
DTHybrid score 0.343
Glutamate [NMDA] receptor subunit epsilon-2
Name Glutamate [NMDA] receptor subunit epsilon-2
Gene Name GRIN2B
Pharmacological action yes
Actions antagonist
References
  • Kashiwagi K, Masuko T, Nguyen CD, Kuno T, Tanaka I, Igarashi K, Williams K: Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore. Mol Pharmacol. 2002 Mar;61(3):533-45. - Pubmed
  • Nakazato E, Kato A, Watanabe S: Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model. Pharmacology. 2005 Jan;73(1):8-14. Epub 2004 Sep 27. - Pubmed
  • Maler JM, Esselmann H, Wiltfang J, Kunz N, Lewczuk P, Reulbach U, Bleich S, Ruther E, Kornhuber J: Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons. Brain Res. 2005 Aug 9;1052(2):156-62. - Pubmed
  • Blanpied TA, Boeckman FA, Aizenman E, Johnson JW: Trapping channel block of NMDA-activated responses by amantadine and memantine. J Neurophysiol. 1997 Jan;77(1):309-23. - Pubmed
  • Rogawski MA, Wenk GL: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev. 2003 Fall;9(3):275-308. - Pubmed
DTHybrid score 0.3617
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action unknown
Actions antagonist
References
  • Rammes G, Rupprecht R, Ferrari U, Zieglgansberger W, Parsons CG: The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner. Neurosci Lett. 2001 Jun 22;306(1-2):81-4. - Pubmed
DTHybrid score 0.275
Alpha-7 nicotinic cholinergic receptor subunit
Name Alpha-7 nicotinic cholinergic receptor subunit
Gene Name CHRFAM7A
Pharmacological action unknown
Actions antagonist
References
  • Aracava Y, Pereira EF, Maelicke A, Albuquerque EX: Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons. J Pharmacol Exp Ther. 2005 Mar;312(3):1195-205. Epub 2004 Nov 2. - Pubmed
DTHybrid score 0.3418

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3558
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3274
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3709

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate
References
  • Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. - Pubmed
DTHybrid score 0.2232

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3208
4119 Cytochrome P450 2D6 CYP2D6 0.2391
4757 Cytochrome P450 2C9 CYP2C9 0.2365
4200 Cytochrome P450 1A2 CYP1A2 0.1793
6013 Cytochrome P450 2E1 CYP2E1 0.1645
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.1643
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.159
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.133
1588 Multidrug resistance protein 1 ABCB1 0.1306
4924 Cytochrome P450 2C8 CYP2C8 0.1299
4118 Cytochrome P450 3A5 CYP3A5 0.1145
6145 Solute carrier family 22 member 1 SLC22A1 0.1053
6024 Cytochrome P450 1A1 CYP1A1 0.0847
6107 Cytochrome P450 3A7 CYP3A7 0.0847
3923 Cholinesterase BCHE 0.0826
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0755
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0745
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0714
831 D(2) dopamine receptor DRD2 0.0637
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0627
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0592
713 Sodium-dependent dopamine transporter SLC6A3 0.0589
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0583
696 Kappa-type opioid receptor OPRK1 0.0577
587 Serum albumin ALB 0.0576
824 Sodium-dependent serotonin transporter SLC6A4 0.0549
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0513
6106 Cytochrome P450 2C18 CYP2C18 0.0489
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0479
492 Histamine H1 receptor HRH1 0.0466
590 5-hydroxytryptamine 2C receptor HTR2C 0.0453
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0433
20 Prostaglandin G/H synthase 1 PTGS1 0.0421
6147 Solute carrier family 22 member 3 SLC22A3 0.042
174 Sigma 1-type opioid receptor SIGMAR1 0.0409
847 Mu-type opioid receptor OPRM1 0.0389
118 Organic cation/carnitine transporter 2 SLC22A5 0.0387
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0385
502 5-hydroxytryptamine 2A receptor HTR2A 0.0371
467 Delta-type opioid receptor OPRD1 0.0348
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0338
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.033
3811 Cytochrome P450 19A1 CYP19A1 0.0315
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0295
766 Beta-2 adrenergic receptor ADRB2 0.0293
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.029
482 Glycine receptor subunit alpha-1 GLRA1 0.0275
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0261
1729 Solute carrier family 22 member 6 SLC22A6 0.0258
833 Organic cation/carnitine transporter 1 SLC22A4 0.0254
556 Alpha-1A adrenergic receptor ADRA1A 0.0253
6142 Solute carrier family 22 member 8 SLC22A8 0.0252
318 Alpha-2A adrenergic receptor ADRA2A 0.0249
638 D(3) dopamine receptor DRD3 0.0236
23 D(1A) dopamine receptor DRD1 0.0233
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0233
468 Cytochrome P450 4A11 CYP4A11 0.0232
3939 Amine oxidase [flavin-containing] B MAOB 0.0226
862 Multidrug resistance-associated protein 1 ABCC1 0.022
916 Metabotropic glutamate receptor 1 GRM1 0.0213
885 5-hydroxytryptamine 1B receptor HTR1B 0.0208
776 Bile salt export pump ABCB11 0.0203
320 5-hydroxytryptamine 1A receptor HTR1A 0.0203
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0201
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.02
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.02
1898 Cytochrome P450 1B1 CYP1B1 0.0199
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0196
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0195
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0193
632 Alpha-1B adrenergic receptor ADRA1B 0.0189
537 ATP synthase delta chain, mitochondrial ATP5D 0.0184
193 Beta-1 adrenergic receptor ADRB1 0.0184
378 Alpha-2C adrenergic receptor ADRA2C 0.0177
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0175
4096 Metabotropic glutamate receptor 3 GRM3 0.0174
1362 Metabotropic glutamate receptor 2 GRM2 0.0174
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0172
629 Alpha-2B adrenergic receptor ADRA2B 0.0168
694 Matrix protein 2 M 0.0168
260 Cytochrome P450 51 ERG11 0.0167
761 Cytochrome P450 51 ERG11 0.0167
3163 Cytochrome P450 51 cyp51 0.0167
94 5-hydroxytryptamine 4 receptor HTR4 0.0164
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0163
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0163
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0163
1268 Neuropeptide S receptor NPSR1 0.0163
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0163
528 5-hydroxytryptamine 1E receptor HTR1E 0.0162
6143 Solute carrier family 22 member 7 SLC22A7 0.0158
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0157
2178 Metabotropic glutamate receptor 5 GRM5 0.0157
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0156
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0156
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0154
6014 Cytochrome P450 2A13 CYP2A13 0.0153
124 Histamine H2 receptor HRH2 0.0153
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0153
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.015
716 5-hydroxytryptamine 7 receptor HTR7 0.015
474 Acetylcholinesterase ACHE 0.0149
3941 Amine oxidase [flavin-containing] A MAOA 0.0148
7 Nitric oxide synthase, inducible NOS2 0.0144
725 5-hydroxytryptamine 1D receptor HTR1D 0.0143
6073 Potassium channel subfamily K member 9 KCNK9 0.0143
6072 Potassium channel subfamily K member 3 KCNK3 0.0143
465 Calmodulin CALM1 0.014
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0138
432 D(4) dopamine receptor DRD4 0.0138
705 Glutamate receptor 1 GRIA1 0.0137
427 Substance-P receptor TACR1 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0136
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0135
136 Estrogen receptor ESR1 0.0133
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0133
1256 5-hydroxytryptamine 6 receptor HTR6 0.0126
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0126
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0123
6136 Multidrug resistance-associated protein 5 ABCC5 0.0122
731 HIV-1 protease HIV-1 protease 0.0121
251 Alcohol dehydrogenase 1A ADH1A 0.0118
163 D(1B) dopamine receptor DRD5 0.0118
789 Alpha-1D adrenergic receptor ADRA1D 0.0117
2164 Multidrug resistance-associated protein 4 ABCC4 0.0117
820 Glycine receptor subunit alpha-2 GLRA2 0.0117
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0116
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0115
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0115
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0111
290 Prostaglandin G/H synthase 2 PTGS2 0.0107
921 Glutamate receptor 2 GRIA2 0.0105
444 Alcohol dehydrogenase 1B ADH1B 0.0105
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0104
2207 Rhodopsin RHO 0.0103
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0101
6137 Multidrug resistance-associated protein 6 ABCC6 0.0101
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0101
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.01
122 P2Y purinoceptor 12 P2RY12 0.0098
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0097
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0094
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0094
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0094
6031 Cytochrome P450 3A43 CYP3A43 0.0092
517 Alcohol dehydrogenase 1C ADH1C 0.009
817 DNA topoisomerase 2-alpha TOP2A 0.009
131 Synaptic vesicular amine transporter SLC18A2 0.009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.009
319 Opioid receptor, sigma 1 OPRS1 0.0089
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0087
922 Glutamate receptor 4 GRIA4 0.0087
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0087
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0087
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0087
4018 Glutamate receptor delta-2 subunit GRID2 0.0087
4027 Glutamate receptor delta-1 subunit GRID1 0.0087
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0087
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0087
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0087
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0087
4019 Excitatory amino acid transporter 4 SLC1A6 0.0087
4026 Aspartyl aminopeptidase DNPEP 0.0087
1912 Excitatory amino acid transporter 1 SLC1A3 0.0087
4016 Excitatory amino acid transporter 5 SLC1A7 0.0087
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0087
1047 Excitatory amino acid transporter 2 SLC1A2 0.0087
664 Glutamate decarboxylase 2 GAD2 0.0087
3890 Glutamate decarboxylase 2 GAD2 0.0087
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0087
4020 Glutamyl aminopeptidase ENPEP 0.0087
927 Metabotropic glutamate receptor 8 GRM8 0.0087
925 Metabotropic glutamate receptor 4 GRM4 0.0087
926 Metabotropic glutamate receptor 7 GRM7 0.0087
4017 5-oxoprolinase OPLAH 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
738 Monocarboxylate transporter 1 SLC16A1 0.0086
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0086
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0085
4120 NADPH--cytochrome P450 reductase POR 0.0085
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0084
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0083
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0081
891 Dihydropteroate synthase folP 0.008
5359 Dihydropteroate synthase folP 0.008
7175 Dihydropteroate synthase sulI 0.008
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0079
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0079
6102 Arylamine N-acetyltransferase 2 NAT2 0.0079
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0078
146 Androgen receptor AR 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0076
477 DNA topoisomerase 4 subunit A parC 0.0076
886 DNA topoisomerase 4 subunit A parC 0.0076
6226 DNA topoisomerase 4 subunit A parC 0.0076
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0075
404 DNA gyrase subunit A gyrA 0.0075
6224 DNA gyrase subunit A gyrA 0.0075
6148 Multidrug resistance-associated protein 7 ABCC10 0.0074
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
6151 Monocarboxylate transporter 10 SLC16A10 0.0074
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0074
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0074
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0074
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0074
5 Glutaminase liver isoform, mitochondrial GLS2 0.0074
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0074
5261 Phosphoribosylformylglycinamidine synthase purL 0.0074
917 Glutaminase kidney isoform, mitochondrial GLS 0.0074
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0074
625 Glutamate carboxypeptidase 2 FOLH1 0.0074
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0073
665 Phosphoserine aminotransferase PSAT1 0.0073
4652 Phosphoserine aminotransferase serC 0.0073
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0073
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0073
420 Glutamate decarboxylase 1 GAD1 0.0073
3900 Glutamate decarboxylase 1 GAD1 0.0073
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0073
3904 Alanine aminotransferase 2 GPT2 0.0072
735 Alanine aminotransferase 1 GPT 0.0072
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.007
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0069
3426 Glutamine synthetase glnA 0.0069
3987 Glutamine synthetase GLUL 0.0069
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0069
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0069
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0069
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0069
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0069
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0069
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0068
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0068
4061 Peroxisomal sarcosine oxidase PIPOX 0.0068
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0068
4057 Glycine N-acyltransferase GLYAT 0.0068
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0068
4056 N-arachidonyl glycine receptor GPR18 0.0068
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0068
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0068
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0068
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0068
1466 Glycyl-tRNA synthetase GARS 0.0068
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0068
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0068
2230 Catalase CAT 0.0067
3249 Catalase katA 0.0067
3625 Catalase katA 0.0067
4539 Catalase katA 0.0067
4941 Catalase katB 0.0067
4773 Deoxycytidine kinase DCK 0.0067
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0067
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
3877 Growth-inhibiting protein 18 GIG18 0.0067
1671 Excitatory amino acid transporter 3 SLC1A1 0.0067
164 Histamine H4 receptor HRH4 0.0067
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0066
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0066
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0066
923 Glutamate receptor 3 GRIA3 0.0066
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0066
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0066
763 Tyrosine aminotransferase TAT 0.0066
5493 Tyrosine aminotransferase Not Available 0.0066
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0065
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0064
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0064
426 Aspartate aminotransferase, mitochondrial GOT2 0.0063
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0063
33 Cystine/glutamate transporter SLC7A11 0.0063
4203 Histamine N-methyltransferase HNMT 0.0062
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0062
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0061
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0061
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0061
563 Thyroid peroxidase TPO 0.006
586 Aspartate aminotransferase, cytoplasmic GOT1 0.006
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.006
1757 Myeloperoxidase MPO 0.006
6432 Transporter snf 0.006
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0059
4238 50S ribosomal protein L4 rplD 0.0059
5578 50S ribosomal protein L4 rplD 0.0059
6173 50S ribosomal protein L4 rplD 0.0059
6219 50S ribosomal protein L4 rplD 0.0059
869 Estrogen receptor beta ESR2 0.0059
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0057
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0057
380 Cytochrome P450 17A1 CYP17A1 0.0057
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0057
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0057
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0057
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0057
1010 Cytochrome P450 51A1 CYP51A1 0.0056
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0056
62 Glycine receptor subunit beta GLRB 0.0056
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0056
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0056
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0056
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0056
161 Tubulin beta chain TUBB 0.0056
312 Tubulin beta chain TUB2 0.0056
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
4237 50S ribosomal protein L22 rplV 0.0054
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0054
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0054
504 Mast/stem cell growth factor receptor KIT 0.0053
6220 Aryl hydrocarbon receptor AHR 0.0053
1656 CYP2B protein CYP2B 0.0053
6141 Sodium/bile acid cotransporter SLC10A1 0.0053
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0052
3884 SHMT2 protein SHMT2 0.0052
3901 SHMT2 protein SHMT2 0.0052
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0052
3879 Serine hydroxymethyltransferase 2 Not Available 0.0052
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0052
4217 Telomerase reverse transcriptase TERT 0.0052
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0052
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0051
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0051
871 Glucocorticoid receptor NR3C1 0.005
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.005
207 Glutathione synthetase GSS 0.005
5269 Glutathione synthetase gshB 0.005
756 Sex hormone-binding globulin SHBG 0.0049
411 Glycine N-methyltransferase GNMT 0.0049
844 Epidermal growth factor receptor EGFR 0.0049
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0049
3932 Glutathione S-transferase A2 GSTA2 0.0049
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0048
84 Nuclear receptor 0B1 NR0B1 0.0048
6070 Nischarin NISCH 0.0048
461 Glycine receptor subunit alpha-3 GLRA3 0.0048
4604 Liver carboxylesterase 1 CES1 0.0048
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0047
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
383 Glycine amidinotransferase, mitochondrial GATM 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0046
518 Peroxidase/catalase T katG 0.0046
818 50S ribosomal protein L10 rplJ 0.0045
436 5-hydroxytryptamine 2B receptor HTR2B 0.0045
349 Serine--pyruvate aminotransferase AGXT 0.0045
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0045
811 Translocator protein TSPO 0.0045
106 Cannabinoid receptor 2 CNR2 0.0044
6182 Cytochrome P450 2J2 CYP2J2 0.0044
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0044
6174 50S ribosomal protein L32 rpmF 0.0044
3947 Xanthine dehydrogenase/oxidase XDH 0.0044
1517 Beta-3 adrenergic receptor ADRB3 0.0043
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0043
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0043
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0042
1618 High affinity nerve growth factor receptor NTRK1 0.0042
1830 5'-nucleotidase NT5E 0.0042
68 Cannabinoid receptor 1 CNR1 0.0042
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0042
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0041
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0041
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0041
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0041
6163 Copper-transporting ATPase 2 ATP7B 0.0041
6165 Copper-transporting ATPase 1 ATP7A 0.0041
228 Beta platelet-derived growth factor receptor PDGFRB 0.0041
125 DNA polymerase beta POLB 0.004
2320 Thymidine kinase, cytosolic TK1 0.004
373 Transthyretin TTR 0.0039
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0039
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0038
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0038
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0038
1192 Sulfotransferase 1A1 SULT1A1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0038
26 Vascular endothelial growth factor receptor 3 FLT4 0.0037
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0037
908 Glutathione S-transferase theta-1 GSTT1 0.0037
275 Arachidonate 5-lipoxygenase ALOX5 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
828 Phenylalanine-4-hydroxylase PAH 0.0037
3109 Phenylalanine-4-hydroxylase phhA 0.0037
527 Prostacyclin receptor PTGIR 0.0036
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0036
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0036
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0036
723 Cytosolic phospholipase A2 PLA2G4A 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
32 Vascular endothelial growth factor receptor 1 FLT1 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
904 Glutathione S-transferase P GSTP1 0.0035
672 Prostaglandin F2-alpha receptor PTGFR 0.0035
5126 Arginase rocF 0.0035
3611 Cytidine deaminase cdd 0.0035
3707 Cytidine deaminase cdd 0.0035
4211 Cytidine deaminase CDA 0.0035
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0034
3810 Catechol O-methyltransferase COMT 0.0034
614 Progesterone receptor PGR 0.0034
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
976 Platelet glycoprotein IX GP9 0.0033
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0033
2300 Lysozyme E 0.0033
3633 Lysozyme R 0.0033
5597 Lysozyme 17 0.0033
2298 Cytochrome P450-cam camC 0.0033
6020 Aldehyde oxidase AOX1 0.0033
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0033
896 Glutathione S-transferase Mu 1 GSTM1 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
1341 Histamine H3 receptor HRH3 0.0032
232 Corticosteroid-binding globulin SERPINA6 0.0032
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
6085 Fatty acid-binding protein, intestinal FABP2 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0031
3809 Estrogen-related receptor gamma ESRRG 0.0031
740 Argininosuccinate synthase ASS1 0.0031
865 Argininosuccinate synthase ASS1 0.0031
2680 Argininosuccinate synthase argG 0.0031
3194 Argininosuccinate synthase argG 0.0031
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0031
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.003
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.003
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
215 Sodium channel protein type 11 subunit alpha SCN11A 0.003
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0029
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0029
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0029
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0029
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0029
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0029
407 Vascular endothelial growth factor receptor 2 KDR 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
5934 Cytochrome P450 26A1 CYP26A1 0.0028
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
1039 Histone deacetylase 9 HDAC9 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
49 Endothelin B receptor EDNRB 0.0027
511 5-hydroxytryptamine 1F receptor HTR1F 0.0026
777 Tumor necrosis factor TNF 0.0026
295 Carbonic anhydrase 1 CA1 0.0026
737 Mineralocorticoid receptor NR3C2 0.0026
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0026
85 Growth hormone receptor GHR 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0025
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
581 Cytochrome P450 2R1 CYP2R1 0.0025
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
1864 RET proto-oncogene RET 0.0024
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0024
1629 Transcription factor AP-1 JUN 0.0024
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0024
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0024
3917 Methylenetetrahydrofolate reductase MTHFR 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
592 Carbonic anhydrase 4 CA4 0.0023
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
183 Vascular endothelial growth factor A VEGFA 0.0023
1992 Vitamin D-binding protein GC 0.0023
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0023
153 Dopamine beta-hydroxylase DBH 0.0023
823 Fibroblast growth factor receptor 2 FGFR2 0.0023
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0023
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0022
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
6218 Pannexin-1 PANX1 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0022
469 Annexin A1 ANXA1 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0022
70 Type-1 angiotensin II receptor AGTR1 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0022
1630 Integrin beta-2 ITGB2 0.0021
284 DNA-directed RNA polymerase beta chain rpoB 0.0021
5773 DNA-directed RNA polymerase beta chain rpoB 0.0021
6171 Solute carrier family 28 member 3 SLC28A3 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
5626 Nucleoside diphosphate kinase B NME2 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
702 UMP-CMP kinase CMPK1 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.0019
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
4226 Uridine phosphorylase 2 UPP2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
1253 Interferon gamma IFNG 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
6149 Solute carrier family 22 member 10 SLC22A10 0.0018
277 Purine nucleoside phosphorylase PNP 0.0018
2870 Purine nucleoside phosphorylase punA 0.0018
2945 Purine nucleoside phosphorylase punA 0.0018
4659 Purine nucleoside phosphorylase TM_1596 0.0018
4825 Purine nucleoside phosphorylase TTHA1435 0.0018
856 Vitamin D3 receptor VDR 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
357 Carbonic anhydrase 2 CA2 0.0017
239 Coagulation factor X F10 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
5294 Nucleoside diphosphate kinase A NME1 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0016
267 Plasminogen activator inhibitor 1 SERPINE1 0.0016
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0015
29 Tubulin beta-1 chain TUBB1 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
1275 Estrogen sulfotransferase SULT1E1 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6126 Carbonic anhydrase 7 CA7 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
798 Osteocalcin BGLAP 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
1050 Bile salt sulfotransferase SULT2A1 0.0014
4311 tRNA TRDMT1 0.0013
4325 tRNA trmD 0.0013
4328 tRNA trmD 0.0013
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
936 Ephrin type-A receptor 2 EPHA2 0.0013
165 FL cytokine receptor FLT3 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0012
5787 Angiopoietin-1 receptor TEK 0.0012
369 Coagulation factor VII F7 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0012
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0012
634 Squalene monooxygenase SQLE 0.0012
7196 Squalene monooxygenase ERG1 0.0012
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
2808 Chloramphenicol acetyltransferase 3 cat3 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0011
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
3601 Dihydropteroate synthase 1 folP1 0.001
3807 Dihydropteroate synthase 1 folP1 0.001
3808 Dihydropteroate synthase 2 folP2 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
365 Dihydrofolate reductase DHFR 0.001
2381 Dihydrofolate reductase DFR1 0.001
2833 Dihydrofolate reductase Not Available 0.001
2931 Dihydrofolate reductase folA 0.001
3544 Dihydrofolate reductase folA 0.001
3682 Dihydrofolate reductase folA 0.001
6642 Dihydrofolate reductase folA 0.001
6756 Dihydrofolate reductase dfrA 0.001
1353 DNA topoisomerase 1 TOP1 0.001
3552 DNA topoisomerase 1 topA 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0009
3830 Calreticulin CALR 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0008
4102 Proteasome subunit beta type 5 PSMB5 0.0008
4101 Proteasome subunit beta type 1 PSMB1 0.0008
952 Dipeptidyl peptidase 4 DPP4 0.0008
54 Prothrombin F2 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
6044 Serum paraoxonase/lactonase 3 PON3 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
2021 Thrombomodulin THBD 0.0007
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0007
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0006
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0006
572 Integrin alpha-L ITGAL 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
4122 Histone deacetylase 2 HDAC2 0.0006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0006
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0006
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0005
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0005
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
273 Apoptosis regulator Bcl-2 BCL2 0.0005
6043 Putative G-protein coupled receptor 44 GPR44 0.0005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0005
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4984 Neuroglobin NGB 0.0003
4943 Cytochrome c6 petJ 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
5000 HemO hemO 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4972 P450cin cinA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
3093 Catalase HPII katE 0.0003
4952 Catalase/peroxidase katA 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
2119 Cytochrome b5 CYB5A 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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