DT-Web

DB00915 - Amantadine


Identification
Name Amantadine
Accession Number DB00915 (APRD00787)
Type small molecule
Description An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 151.2487
Groups approved
Monoisotopic Weight 151.136099549
Pharmacology
Indication For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Mechanism of action The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with stimulation of norepinephrine response. It also has NMDA receptor antagonistic effects. The antiviral mechanism seems to be unrelated. The drug interferes with a viral protein, M2 (an ion channel), which is needed for the viral particle to become "uncoated" once it is taken inside the cell by endocytosis.
Absorption Amantadine is well absorbed orally from the gastrointestinal tract.
Protein binding Approximately 67% bound to plasma proteins over a concentration range of 0.1 to 2.0 µg/mL.
Biotransformation No appreciable metabolism, although negligible amounts of an acetyl metabolite have been identified.
Route of elimination It is primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Toxicity Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.
Affected organisms
  • Humans and other mammals
  • Various viruses
Interactions
Drug Interactions
Drug Mechanism of interaction
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Memantine Increased risk of CNS adverse effects with this association
Paliperidone The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, amantadine. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Rivastigmine Possible antagonism of action
Thiothixene Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Amantadine. Consider alternate therapy or monitor for decreased effects of both agents.
Ziprasidone The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, amantadine. Consider alternate therapy or monitor for worsening of movement disorder.
Zuclopenthixol Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and amantadine, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


Matrix protein 2
Name Matrix protein 2
Gene Name M
Pharmacological action yes
Actions inhibitor
References
  • Wang C, Takeuchi K, Pinto LH, Lamb RA: Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol. 1993 Sep;67(9):5585-94. - Pubmed
  • Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA: Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10967-72. Epub 2008 Jul 31. - Pubmed
  • Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M: Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc. 2009 Jun 17;131(23):8066-76. - Pubmed
  • Beigel J, Bray M: Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. Epub 2008 Feb 4. - Pubmed
  • Lear JD: Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data. FEBS Lett. 2003 Sep 18;552(1):17-22. - Pubmed
  • Salom D, Hill BR, Lear JD, DeGrado WF: pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry. 2000 Nov 21;39(46):14160-70. - Pubmed
DTHybrid score 1.13
Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action yes
Actions antagonist
References
  • Blanpied TA, Clarke RJ, Johnson JW: Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci. 2005 Mar 30;25(13):3312-22. - Pubmed
  • Hesselink MB, De Boer AG, Breimer DD, Danysz W: Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists. J Neural Transm. 1999;106(5-6):409-21. - Pubmed
DTHybrid score 0.3037
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions agonist
References
  • Tomitaka S, Hashimoto K, Narita N, Minabe Y, Tamura A: Amantadine induces c-fos in rat striatum: reversal with dopamine D1 and NMDA receptor antagonists. Eur J Pharmacol. 1995 Oct 16;285(2):207-11. - Pubmed
  • Ameri A: Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. Br J Pharmacol. 1998 Oct;125(3):461-8. - Pubmed
  • Hirose G: Drug induced parkinsonism: A review. J Neurol. 2006 Aug;253 Suppl 3:iii22-iii24. - doi:10.1007/s00415-006-3004-8
  • Hesselink MB, De Boer AG, Breimer DD, Danysz W: Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists. J Neural Transm. 1999;106(5-6):409-21. - Pubmed
  • Cousins MS, Carriero DL, Salamone JD: Tremulous jaw movements induced by the acetylcholinesterase inhibitor tacrine: effects of antiparkinsonian drugs. Eur J Pharmacol. 1997 Mar 19;322(2-3):137-45. - Pubmed
DTHybrid score 0.347

Enzymes


Aromatic-L-amino-acid decarboxylase
Name Aromatic-L-amino-acid decarboxylase
Gene Name DDC
Actions inducer
References
  • -
  • Li XM, Juorio AV, Qi J, Boulton AA: Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells. J Neurosci Res. 1998 Aug 15;53(4):490-3. - Pubmed
  • Fisher A, Biggs CS, Starr MS: Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase. Amino Acids. 1998;14(1-3):43-9. - Pubmed
DTHybrid score 0.4387
Amine oxidase [flavin-containing] B
Name Amine oxidase [flavin-containing] B
Gene Name MAOB
Actions inhibitor
References
  • -
  • Wesemann W, Ekenna O: Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney of the rat. Arzneimittelforschung. 1982;32(10):1241-3. - Pubmed
DTHybrid score 0.8506

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
  • Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. - Pubmed
  • Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. - Pubmed
  • Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.2745
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
  • Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
  • Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. - Pubmed
  • Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.3289
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.3355

Predictions


Id Partner name Gene Name Score
3941 Amine oxidase [flavin-containing] A MAOA 0.1693
4512 Cytochrome P450 3A4 CYP3A4 0.1684
4119 Cytochrome P450 2D6 CYP2D6 0.1631
23 D(1A) dopamine receptor DRD1 0.1219
502 5-hydroxytryptamine 2A receptor HTR2A 0.1133
4200 Cytochrome P450 1A2 CYP1A2 0.1075
6016 Cytochrome P450 2C19 CYP2C19 0.0979
556 Alpha-1A adrenergic receptor ADRA1A 0.0896
4757 Cytochrome P450 2C9 CYP2C9 0.0848
6030 Cytochrome P450 2B6 CYP2B6 0.0823
4118 Cytochrome P450 3A5 CYP3A5 0.0777
6147 Solute carrier family 22 member 3 SLC22A3 0.0706
807 D-alanine--D-alanine ligase A ddlA 0.0692
894 Alanine racemase alr 0.0691
2453 Alanine racemase alr 0.0691
638 D(3) dopamine receptor DRD3 0.0655
118 Organic cation/carnitine transporter 2 SLC22A5 0.0634
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0609
6107 Cytochrome P450 3A7 CYP3A7 0.0591
3923 Cholinesterase BCHE 0.0587
4924 Cytochrome P450 2C8 CYP2C8 0.0587
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0582
713 Sodium-dependent dopamine transporter SLC6A3 0.0569
824 Sodium-dependent serotonin transporter SLC6A4 0.0565
6013 Cytochrome P450 2E1 CYP2E1 0.0554
318 Alpha-2A adrenergic receptor ADRA2A 0.0547
432 D(4) dopamine receptor DRD4 0.0533
378 Alpha-2C adrenergic receptor ADRA2C 0.0525
320 5-hydroxytryptamine 1A receptor HTR1A 0.0522
629 Alpha-2B adrenergic receptor ADRA2B 0.051
632 Alpha-1B adrenergic receptor ADRA1B 0.0493
833 Organic cation/carnitine transporter 1 SLC22A4 0.0472
163 D(1B) dopamine receptor DRD5 0.047
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0468
341 5-hydroxytryptamine 3 receptor HTR3A 0.0468
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0461
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0446
587 Serum albumin ALB 0.042
766 Beta-2 adrenergic receptor ADRB2 0.0416
193 Beta-1 adrenergic receptor ADRB1 0.0407
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0406
492 Histamine H1 receptor HRH1 0.0401
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0395
590 5-hydroxytryptamine 2C receptor HTR2C 0.0392
174 Sigma 1-type opioid receptor SIGMAR1 0.0384
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0384
6142 Solute carrier family 22 member 8 SLC22A8 0.037
6024 Cytochrome P450 1A1 CYP1A1 0.0367
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0351
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0349
789 Alpha-1D adrenergic receptor ADRA1D 0.0344
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0324
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0319
6151 Monocarboxylate transporter 10 SLC16A10 0.0319
131 Synaptic vesicular amine transporter SLC18A2 0.0313
5718 Cytochrome P450 2A6 CYP2A6 0.0313
862 Multidrug resistance-associated protein 1 ABCC1 0.0311
51 Muscarinic acetylcholine receptor M3 CHRM3 0.03
1729 Solute carrier family 22 member 6 SLC22A6 0.0293
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0276
776 Bile salt export pump ABCB11 0.0259
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0243
436 5-hydroxytryptamine 2B receptor HTR2B 0.0243
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0238
90 Tryptophan 5-hydroxylase 2 TPH2 0.0238
2864 Penton protein PIII 0.0236
725 5-hydroxytryptamine 1D receptor HTR1D 0.0235
885 5-hydroxytryptamine 1B receptor HTR1B 0.0233
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0219
124 Histamine H2 receptor HRH2 0.0215
1517 Beta-3 adrenergic receptor ADRB3 0.0212
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0207
5841 Insulin-like growth factor IB IGF1 0.0206
6143 Solute carrier family 22 member 7 SLC22A7 0.0202
765 Indoleamine 2,3-dioxygenase IDO1 0.0198
716 5-hydroxytryptamine 7 receptor HTR7 0.0196
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0193
474 Acetylcholinesterase ACHE 0.0193
465 Calmodulin CALM1 0.0193
3810 Catechol O-methyltransferase COMT 0.0186
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0186
3811 Cytochrome P450 19A1 CYP19A1 0.0186
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0181
828 Phenylalanine-4-hydroxylase PAH 0.0177
3109 Phenylalanine-4-hydroxylase phhA 0.0177
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0176
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0176
6106 Cytochrome P450 2C18 CYP2C18 0.0175
134 Tryptophan 5-hydroxylase 1 TPH1 0.0175
4096 Metabotropic glutamate receptor 3 GRM3 0.0174
1362 Metabotropic glutamate receptor 2 GRM2 0.0174
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0174
6012 Tryptophan 2,3-dioxygenase TDO2 0.0173
2452 Tryptophanyl-tRNA synthetase trpS 0.0173
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0168
273 Apoptosis regulator Bcl-2 BCL2 0.0162
199 Monocarboxylate transporter 8 SLC16A2 0.0162
20 Prostaglandin G/H synthase 1 PTGS1 0.0162
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.016
6010 Thiamine transporter 1 SLC19A2 0.0159
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0159
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0157
916 Metabotropic glutamate receptor 1 GRM1 0.0157
2178 Metabotropic glutamate receptor 5 GRM5 0.0157
1024 Solute carrier family 22 member 11 SLC22A11 0.0152
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0151
1898 Cytochrome P450 1B1 CYP1B1 0.0146
467 Delta-type opioid receptor OPRD1 0.0144
847 Mu-type opioid receptor OPRM1 0.0143
427 Substance-P receptor TACR1 0.0143
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0138
6148 Multidrug resistance-associated protein 7 ABCC10 0.0137
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
4773 Deoxycytidine kinase DCK 0.0137
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0132
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0128
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0123
2164 Multidrug resistance-associated protein 4 ABCC4 0.0122
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0122
136 Estrogen receptor ESR1 0.0122
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0118
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
7 Nitric oxide synthase, inducible NOS2 0.0116
6137 Multidrug resistance-associated protein 6 ABCC6 0.011
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.011
146 Androgen receptor AR 0.0109
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0108
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0106
817 DNA topoisomerase 2-alpha TOP2A 0.0105
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0105
696 Kappa-type opioid receptor OPRK1 0.0105
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0102
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0102
871 Glucocorticoid receptor NR3C1 0.0099
6141 Sodium/bile acid cotransporter SLC10A1 0.0098
1256 5-hydroxytryptamine 6 receptor HTR6 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
731 HIV-1 protease HIV-1 protease 0.0097
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0096
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0096
1757 Myeloperoxidase MPO 0.0094
4203 Histamine N-methyltransferase HNMT 0.0093
3947 Xanthine dehydrogenase/oxidase XDH 0.0092
477 DNA topoisomerase 4 subunit A parC 0.0092
886 DNA topoisomerase 4 subunit A parC 0.0092
6226 DNA topoisomerase 4 subunit A parC 0.0092
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0091
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0091
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0091
404 DNA gyrase subunit A gyrA 0.009
6224 DNA gyrase subunit A gyrA 0.009
319 Opioid receptor, sigma 1 OPRS1 0.009
6136 Multidrug resistance-associated protein 5 ABCC5 0.009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0089
6070 Nischarin NISCH 0.0089
380 Cytochrome P450 17A1 CYP17A1 0.0089
923 Glutamate receptor 3 GRIA3 0.0086
756 Sex hormone-binding globulin SHBG 0.0083
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0083
738 Monocarboxylate transporter 1 SLC16A1 0.0083
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0081
869 Estrogen receptor beta ESR2 0.0081
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.008
6171 Solute carrier family 28 member 3 SLC28A3 0.0079
468 Cytochrome P450 4A11 CYP4A11 0.0078
1830 5'-nucleotidase NT5E 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0075
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0075
3611 Cytidine deaminase cdd 0.0074
3707 Cytidine deaminase cdd 0.0074
4211 Cytidine deaminase CDA 0.0074
125 DNA polymerase beta POLB 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0073
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0073
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.007
1770 Phospholipase C PLCL1 0.007
2841 Phospholipase C plc 0.007
164 Histamine H4 receptor HRH4 0.0069
153 Dopamine beta-hydroxylase DBH 0.0068
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0068
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0068
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
3913 Glutamic acid decarboxylase GAD65 0.0066
735 Alanine aminotransferase 1 GPT 0.0065
3904 Alanine aminotransferase 2 GPT2 0.0065
5126 Arginase rocF 0.0064
4120 NADPH--cytochrome P450 reductase POR 0.0064
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0062
614 Progesterone receptor PGR 0.0061
1341 Histamine H3 receptor HRH3 0.006
161 Tubulin beta chain TUBB 0.006
312 Tubulin beta chain TUB2 0.006
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0059
504 Mast/stem cell growth factor receptor KIT 0.0059
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0059
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
2449 Tubulin alpha-3 chain TUBA1A 0.0057
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0056
1656 CYP2B protein CYP2B 0.0056
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0056
1192 Sulfotransferase 1A1 SULT1A1 0.0055
921 Glutamate receptor 2 GRIA2 0.0055
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0055
528 5-hydroxytryptamine 1E receptor HTR1E 0.0054
251 Alcohol dehydrogenase 1A ADH1A 0.0054
6432 Transporter snf 0.0054
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0053
4604 Liver carboxylesterase 1 CES1 0.0053
6859 Protein S100-A4 S100A4 0.0053
702 UMP-CMP kinase CMPK1 0.0053
6165 Copper-transporting ATPase 1 ATP7A 0.0052
6163 Copper-transporting ATPase 2 ATP7B 0.0052
6182 Cytochrome P450 2J2 CYP2J2 0.0052
976 Platelet glycoprotein IX GP9 0.0052
908 Glutathione S-transferase theta-1 GSTT1 0.0052
6014 Cytochrome P450 2A13 CYP2A13 0.0052
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0051
290 Prostaglandin G/H synthase 2 PTGS2 0.0051
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0051
820 Glycine receptor subunit alpha-2 GLRA2 0.0051
449 Ornithine decarboxylase ODC1 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0051
228 Beta platelet-derived growth factor receptor PDGFRB 0.0051
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0051
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.005
6146 High affinity copper uptake protein 1 SLC31A1 0.005
342 P protein [Includes: DNA-directed DNA polymerase P 0.005
612 P protein [Includes: DNA-directed DNA polymerase P 0.005
844 Epidermal growth factor receptor EGFR 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
737 Mineralocorticoid receptor NR3C2 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0049
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0049
904 Glutathione S-transferase P GSTP1 0.0049
6167 Organic solute transporter subunit beta OSTB 0.0049
6166 Organic solute transporter subunit alpha OSTA 0.0049
6031 Cytochrome P450 3A43 CYP3A43 0.0049
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0049
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0048
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0048
2300 Lysozyme E 0.0047
3633 Lysozyme R 0.0047
5597 Lysozyme 17 0.0047
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0046
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
5626 Nucleoside diphosphate kinase B NME2 0.0043
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0043
1268 Neuropeptide S receptor NPSR1 0.0043
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0043
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0043
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0043
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0043
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
517 Alcohol dehydrogenase 1C ADH1C 0.0043
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
2207 Rhodopsin RHO 0.0042
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0041
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
94 5-hydroxytryptamine 4 receptor HTR4 0.004
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.004
1636 Trace amine-associated receptor 1 TAAR1 0.0039
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0039
6211 Tubulin epsilon chain TUBE1 0.0039
6212 Tubulin gamma-1 chain TUBG1 0.0039
6210 Tubulin delta chain TUBD1 0.0039
6149 Solute carrier family 22 member 10 SLC22A10 0.0039
6073 Potassium channel subfamily K member 9 KCNK9 0.0039
6072 Potassium channel subfamily K member 3 KCNK3 0.0039
420 Glutamate decarboxylase 1 GAD1 0.0039
3900 Glutamate decarboxylase 1 GAD1 0.0039
665 Phosphoserine aminotransferase PSAT1 0.0039
4652 Phosphoserine aminotransferase serC 0.0039
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0039
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0039
3893 DDC protein DDC 0.0038
1864 RET proto-oncogene RET 0.0038
1629 Transcription factor AP-1 JUN 0.0038
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0038
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0038
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0038
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0038
1618 High affinity nerve growth factor receptor NTRK1 0.0038
6085 Fatty acid-binding protein, intestinal FABP2 0.0038
1483 Membrane copper amine oxidase AOC3 0.0037
3891 Putative L-Dopa decarboxylase DDC 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0037
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0037
527 Prostacyclin receptor PTGIR 0.0036
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
763 Tyrosine aminotransferase TAT 0.0036
5493 Tyrosine aminotransferase Not Available 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
3877 Growth-inhibiting protein 18 GIG18 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
5294 Nucleoside diphosphate kinase A NME1 0.0035
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0035
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0034
6218 Pannexin-1 PANX1 0.0034
426 Aspartate aminotransferase, mitochondrial GOT2 0.0034
751 Potassium channel subfamily K member 6 KCNK6 0.0034
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0033
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0033
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0033
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
1360 Sphingomyelin phosphodiesterase SMPD1 0.0032
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0032
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0032
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0031
172 Potassium channel subfamily K member 1 KCNK1 0.0031
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0031
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0031
3911 Uncharacterized protein C20orf38 SPTLC3 0.0031
3906 Serine dehydratase-like SDSL 0.0031
3881 Selenocysteine lyase variant Not Available 0.0031
3887 Phosphorylase PYGB 0.0031
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0031
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0031
3878 GAD1 protein GAD1 0.0031
3883 Ornithine aminotransferase variant Not Available 0.0031
306 Pyridoxal phosphate phosphatase PDXP 0.0031
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0031
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0031
3880 Serine hydroxymethyltransferase 1 Not Available 0.0031
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0031
3894 KIAA0251 protein PDXDC1 0.0031
3875 Glycogen phosphorylase, brain form PYGB 0.0031
3882 Brain glycogen phosphorylase variant Not Available 0.0031
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0031
3886 Migration-inducing protein 4 ALAS1 0.0031
3905 Molybdenum cofactor sulfurase MOCOS 0.0031
4217 Telomerase reverse transcriptase TERT 0.0031
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.003
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.003
537 ATP synthase delta chain, mitochondrial ATP5D 0.003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0029
26 Vascular endothelial growth factor receptor 3 FLT4 0.0029
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0029
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0029
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0029
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0029
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0029
683 Potassium transporter GK0582 0.0029
70 Type-1 angiotensin II receptor AGTR1 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0027
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
3 Histidine decarboxylase HDC 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0026
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
727 Serine palmitoyltransferase 2 SPTLC2 0.0026
491 Serine palmitoyltransferase 1 SPTLC1 0.0026
184 L-serine dehydratase SDS 0.0026
431 Serine racemase SRR 0.0026
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0026
89 Cysteine sulfinic acid decarboxylase CSAD 0.0026
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
534 Threonine synthase-like 1 THNSL1 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0026
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0026
499 Arginine decarboxylase ADC 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0026
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0026
489 Monocarboxylate transporter 2 SLC16A7 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0025
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
435 Kynureninase KYNU 0.0024
4654 Kynureninase kynU 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
169 Cysteine desulfurase, mitochondrial NFS1 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
358 Cystathionine beta-synthase CBS 0.0023
3884 SHMT2 protein SHMT2 0.0023
3901 SHMT2 protein SHMT2 0.0023
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0023
3879 Serine hydroxymethyltransferase 2 Not Available 0.0023
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0023
2320 Thymidine kinase, cytosolic TK1 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0023
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0023
472 Ornithine aminotransferase, mitochondrial OAT 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0022
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0022
868 Cystathionine gamma-lyase CTH 0.0022
605 Fumarate reductase flavoprotein subunit frdA 0.0022
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0022
3673 Fumarate reductase flavoprotein subunit fccA 0.0022
4912 Fumarate reductase flavoprotein subunit ifcA 0.0022
6549 Fumarate reductase flavoprotein subunit frdA 0.0022
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
349 Serine--pyruvate aminotransferase AGXT 0.002
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.002
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.002
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
3587 Gastrotropin FABP6 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
6133 Sodium channel subunit beta-2 SCN2B 0.0018
6134 Sodium channel subunit beta-3 SCN3B 0.0018
6132 Sodium channel subunit beta-1 SCN1B 0.0018
6135 Sodium channel subunit beta-4 SCN4B 0.0018
6127 Carbonic anhydrase-related protein CA8 0.0018
6129 Carbonic anhydrase-related protein 11 CA11 0.0018
6128 Carbonic anhydrase-related protein 10 CA10 0.0018
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0018
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0018
10 Glycogen phosphorylase, liver form PYGL 0.0018
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
6130 Carbonic anhydrase 13 CA13 0.0018
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0018
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0017
6677 Myelin P2 protein PMP2 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
6131 Carbonic anhydrase 14 CA14 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6755 Poliovirus receptor PVR 0.0015
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0015
6122 Carbonic anhydrase 3 CA3 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0015
6689 TraN protein traN 0.0015
6672 Destrin DSTN 0.0015
6680 Cofilin-1 CFL1 0.0015
6670 Ig kappa chain V-I region Bi Not Available 0.0015
6671 Ig heavy chain V-III region VH26 Not Available 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
6688 TraF protein traF 0.0015
6404 Rhomboid protease glpG glpG 0.0015
6797 Rhomboid protease glpG glpG 0.0015
3710 Acyl-CoA thioesterase 2 tesB 0.0015
922 Glutamate receptor 4 GRIA4 0.0015
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0015
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0015
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0015
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0015
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0015
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0015
4018 Glutamate receptor delta-2 subunit GRID2 0.0015
4027 Glutamate receptor delta-1 subunit GRID1 0.0015
1912 Excitatory amino acid transporter 1 SLC1A3 0.0015
4019 Excitatory amino acid transporter 4 SLC1A6 0.0015
6685 Outer membrane protein II porB 0.0015
6690 BenF-like porin PFL_1329 0.0015
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0015
4016 Excitatory amino acid transporter 5 SLC1A7 0.0015
6687 TraO protein traO 0.0015
4026 Aspartyl aminopeptidase DNPEP 0.0015
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0015
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0015
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0015
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0015
1047 Excitatory amino acid transporter 2 SLC1A2 0.0015
6679 Colicin-Ia cia 0.0015
664 Glutamate decarboxylase 2 GAD2 0.0015
3890 Glutamate decarboxylase 2 GAD2 0.0015
6676 Fe(3+)-pyochelin receptor fptA 0.0015
115 Penicillin-binding protein 2 mrdA 0.0015
6069 Penicillin-binding protein 2 mrdA 0.0015
6118 Penicillin-binding protein 2 penA 0.0015
6187 Penicillin-binding protein 2 pbpA 0.0015
6686 Penicillin-binding protein 2 pbp2 0.0015
6939 Penicillin-binding protein 2 mrdA 0.0015
7163 Penicillin-binding protein 2 pbpA 0.0015
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0015
4017 5-oxoprolinase OPLAH 0.0015
927 Metabotropic glutamate receptor 8 GRM8 0.0015
925 Metabotropic glutamate receptor 4 GRM4 0.0015
926 Metabotropic glutamate receptor 7 GRM7 0.0015
4020 Glutamyl aminopeptidase ENPEP 0.0015
165 FL cytokine receptor FLT3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
1152 Glycogen phosphorylase, muscle form PYGM 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
4205 Carbonic anhydrase 9 CA9 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
625 Glutamate carboxypeptidase 2 FOLH1 0.0013
4760 Mll3241 protein mll3241 0.0013
3395 Iron(III) dicitrate transport protein fecA fecA 0.0013
6385 H subunit of photosynthetic reaction center complex puhA 0.0013
6474 Outer membrane protein W ompW 0.0013
6678 Colicin I receptor cirA 0.0013
3578 Protein crcA crcA 0.0013
6675 Colicin-E3 ceaC 0.0013
2925 Long-chain fatty acid transport protein fadL 0.0013
6480 Outer membrane usher protein papC papC 0.0013
6438 Outer membrane protein G ompG 0.0013
2447 Ammonia channel amtB 0.0013
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
295 Carbonic anhydrase 1 CA1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0013
917 Glutaminase kidney isoform, mitochondrial GLS 0.0013
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0013
5 Glutaminase liver isoform, mitochondrial GLS2 0.0013
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0013
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0013
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0013
5261 Phosphoribosylformylglycinamidine synthase purL 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0013
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0013
6020 Aldehyde oxidase AOX1 0.0013
6126 Carbonic anhydrase 7 CA7 0.0013
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0012
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0012
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0012
6524 Protein tonB tonB 0.0012
2679 Vitamin B12 transporter btuB btuB 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
1671 Excitatory amino acid transporter 3 SLC1A1 0.0012
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
6459 Glycodelin PAEP 0.0011
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
705 Glutamate receptor 1 GRIA1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
3426 Glutamine synthetase glnA 0.001
3987 Glutamine synthetase GLUL 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.001
592 Carbonic anhydrase 4 CA4 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6352 Reaction center protein H chain puhA 0.001
6456 Reaction center protein H chain puhA 0.001
6682 Reaction center protein H chain puhA 0.001
6353 Reaction center protein L chain pufL 0.001
6454 Reaction center protein L chain pufL 0.001
6683 Reaction center protein L chain pufL 0.001
6354 Reaction center protein M chain pufM 0.001
6455 Reaction center protein M chain pufM 0.001
6684 Reaction center protein M chain pufM 0.001
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3957 Adenosine deaminase ADA 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
2828 Squalene--hopene cyclase shc 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5095 Putidaredoxin reductase camA 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5081 L-aspartate oxidase nadB 0.0009
1410 Oxidoreductase HSD17B6 0.0009
4725 Oxidoreductase Not Available 0.0009
5124 Oxidoreductase Not Available 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
4439 Ferredoxin reductase bphA4 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
357 Carbonic anhydrase 2 CA2 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0008
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0008
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0008
3594 Deoxyribodipyrimidine photo-lyase phr 0.0008
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0008
5080 Deoxyribodipyrimidine photo-lyase phr 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
5072 N,N-dimethylglycine oxidase dmg 0.0008
2470 Pyruvate oxidase pox5 0.0008
5073 Ferredoxin--NADP reductase petH 0.0008
5076 Ferredoxin--NADP reductase fpr 0.0008
5119 Ferredoxin--NADP reductase petH 0.0008
5121 Ferredoxin--NADP reductase fpr 0.0008
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0008
2268 Cholesterol oxidase choB 0.0008
2822 Cholesterol oxidase choA 0.0008
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0008
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0008
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0008
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0008
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0008
2526 NADPH-ferredoxin reductase fprA fprA 0.0008
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0008
4440 NADH peroxidase npr 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
327 Glutathione reductase gor 0.0007
5110 Glutathione reductase GR2 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
2893 Glycine oxidase thiO 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2567 Thymidylate synthase thyX thyX 0.0007
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0007
2823 Trypanothione reductase TPR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
2769 P-hydroxybenzoate hydroxylase pobA 0.0007
2809 P-hydroxybenzoate hydroxylase pobA 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
6645 D-amino-acid oxidase DAO 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6220 Aryl hydrocarbon receptor AHR 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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