DT-Web: DB00313

Identification

Name

Valproic Acid

Accession Number

DB00313 (APRD00066, APRD00256, DB00510)

Type

small molecule

Description

A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (CAS number: 76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

144.2114

Groups

approved

Monoisotopic Weight

144.115029756

Pharmacology

Indication

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.

Mechanism of action

Valproic Acid dissociates to the valproate ion in the gastrointestinal tract and then binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Valproic Acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is also a histone deacetylase inhibitor. Valproic acid has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. A study published in August 2005 revealed that patients treated with valproic acid in addition to highly active antiretroviral therapy (HAART) showed a 75% reduction in latent HIV infection.

Absorption

Rapid absorption from gastrointestinal tract. Although the rate of valproate ion absorption may vary with the formulation administered (liquid, solid, or sprinkle), conditions of use (e.g., fasting or postprandial) and the method of administration (e.g., whether the contents of the capsule are sprinkled on food or the capsule is taken intact), these differences should be of minor clinical importance under the steady state conditions achieved in chronic use in the treatment of epilepsy. Food has a greater influence on the rate of absorption of the Depakote tablet (increases Tmax from 4 to 8 hours) than on the absorption of Depakote sprinkle capsules (increase Tmax from 3.3 to 4.8 hours). Furthermore, studies suggest that total daily systemic bioavailability (extent of absorption) is the primary determinant of seizure control.

Protein binding

Concentration-dependent, from 90% at 40 ug/mL to 81.5% at 130 ug/mL. Higher than expected free fractions occur in the elderly, in hyperlipidemic patients, and in patients with hepatic and renal diseases. It may also affect the extent of protein binding of other drugs such as phenytoin or carbamazepine.

Biotransformation

Valproic Acid is metabolized almost entirely by the liver. In adult patients on monotherapy, 30-50% of an administered dose appears in urine as a glucuronide conjugate. Mitochondrial ß-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose. Usually, less than 15-20% of the dose is eliminated by other oxidative mechanisms. Less than 3% of an administered dose is excreted unchanged in urine.

Route of elimination

Valproate is metabolized almost entirely by the liver. Less than 3% of an administered dose is excreted unchanged in urine. Mitochondrial ss-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose.

Toxicity

Oral, mouse: LD₅₀ = 1098 mg/kg; Oral, rat: LD₅₀ = 670 mg/kg. Symptoms of overdose may include coma, extreme drowsiness, and heart problems. The safety and tolerability of valproate in pediatric patients were shown to be comparable to those in adults.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetylsalicylic acid	Acetylsalicylic acid increases the effect of valproic acid.
Asenapine	Valproate completely inhibits the glucuronidation of asenapine but does not effect its exposure. Dose adjustment is not necessary with concomitant therapy.
Carbamazepine	Decreases the effect of valproic acid
Clarithromycin	The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Clarithromycin is initiated, discontinued or dose changed.
Eltrombopag	Affects hepatic CYP2C9/10 metabolism, will increase effect/level of eltrombopag.
Erythromycin	The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Erythromycin is initiated, discontinued or dose changed.
Felbamate	Felbamate, a CYP2C19 inhibitor, may decrease the metabolism of Valproic acid, a CYP2C19 substrate. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Felbamate is initiated, discontinued or dose changed.
Glycerol Phenylbutyrate	Valproic acid may induce hyperammonemia. Monitor ammonia levels closely when use of valproic acid is necessary in UCD patients.
Lacosamide	Valproic acid toxicity may occur at any time during the treatment course and should be considered in patients with acute changes in mentation, especially if there has been a recent change in antiepileptic therapy.
Lamotrigine	Valproic acid may increase the adverse effects of Lamotrigine by increasing Lamotrigine serum concentration. The Lamotrigine dose should be reduced by 50% during concomitant therapy. Monitor for changes in Lamotrigine therapeutic and adverse effects if Valproic acid is initiated, discontinued or dose changed.
Lorazepam	Valproic acid may increase the serum concentration of Lorazepam by reducing Lorazepam metabolism. The Lorazepam dose should be reduced by 50% during concomitant therapy. Monitor for increased Lorazepam effects and toxicity.
Nimodipine	Valproic acid increases the effect of nimodipine
Rifampin	Rifampin may reduce the serum concentration of Valproic acid by increasing Valproic acid metabolism. Valproic acid dose adjustments may be required during concomitant therapy. Monitor Valproic acid serum concentrations, efficacy and toxicity if Rifampin is initiated, discontinued or dose changed.
Rufinamide	Valproic acid may increase the therapeutic/toxic effects of Rufinamide. Consider alternate therapy or monitor for changes in Rufinamide serum concentrations, therapeutic and adverse effects if Valproic acid is initiated, discontinued or dose changed. Decreases clearance of rufinamide and is a selective inhibitor of human carboxylesterase thus increasing serum concentrations.
Silodosin	Strong UGT2B7 inhibitors may increase levels of silodosin. Monitor concomitant therapy closely.
Telithromycin	The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Telithromycin is initiated, discontinued or dose changed.
Tipranavir	Tipranavir decreases the concentration of Valproic acid. Monitor Valproid acid efficacy.
Vigabatrin	Vigabatrin reduces serum concentrations of valproic acid by 8%.

Food Interactions

Take with food.
Avoid alcohol.
Do not take with milk.

Histone deacetylase 9
Name	Histone deacetylase 9
Gene Name	HDAC9
Pharmacological action	yes
Actions	inhibitor
References	Ylisastigui L, Archin NM, Lehrman G, Bosch RJ, Margolis DM: Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression. AIDS. 2004 May 21;18(8):1101-8. - Pubmed Michaelis M, Kohler N, Reinisch A, Eikel D, Gravemann U, Doerr HW, Nau H, Cinatl J Jr: Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acid. Biochem Pharmacol. 2004 Aug 1;68(3):531-8. - Pubmed Kanai H, Sawa A, Chen RW, Leeds P, Chuang DM: Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons. Pharmacogenomics J. 2004;4(5):336-44. - Pubmed Stockhausen MT, Sjolund J, Manetopoulos C, Axelson H: Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells. Br J Cancer. 2005 Feb 28;92(4):751-9. - Pubmed Beutler AS, Li S, Nicol R, Walsh MJ: Carbamazepine is an inhibitor of histone deacetylases. Life Sci. 2005 May 13;76(26):3107-15. - Pubmed Rosenberg G: The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. - Pubmed Kawano T, Akiyama M, Agawa-Ohta M, Mikami-Terao Y, Iwase S, Yanagisawa T, Ida H, Agata N, Yamada H: Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation. Int J Oncol. 2010 Oct;37(4):787-95. - Pubmed
DTHybrid score	0.2202
4-aminobutyrate aminotransferase, mitochondrial
Name	4-aminobutyrate aminotransferase, mitochondrial
Gene Name	ABAT
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Loscher W: Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice. Biochem Pharmacol. 1982 Mar 1;31(5):837-42. - Pubmed Ha JH, Lee DU, Lee JT, Kim JS, Yong CS, Kim JA, Ha JS, Huh K: 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol. 2000 Nov;73(1-2):329-33. - Pubmed Semba J, Kuroda Y, Takahashi R: Potential antidepressant properties of subchronic GABA transaminase inhibitors in the forced swimming test in mice. Neuropsychobiology. 1989;21(3):152-6. - Pubmed Rosenberg G: The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. - Pubmed
DTHybrid score	0.5551
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Name	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Name	ACADSB
Pharmacological action	unknown
Actions	inhibitor
References	Ito M, Ikeda Y, Arnez JG, Finocchiaro G, Tanaka K: The enzymatic basis for the metabolism and inhibitory effects of valproic acid: dehydrogenation of valproyl-CoA by 2-methyl-branched-chain acyl-CoA dehydrogenase. Biochim Biophys Acta. 1990 May 16;1034(2):213-8. - Pubmed Bazinet RP, Weis MT, Rapoport SI, Rosenberger TA: Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. Psychopharmacology (Berl). 2006 Jan;184(1):122-9. Epub 2005 Dec 13. - Pubmed
DTHybrid score	0.3105
2-oxoglutarate dehydrogenase E1 component, mitochondrial
Name	2-oxoglutarate dehydrogenase E1 component, mitochondrial
Gene Name	OGDH
Pharmacological action	unknown
Actions	inhibitor
References	Johannessen CU, Johannessen SI: Valproate: past, present, and future. CNS Drug Rev. 2003 Summer;9(2):199-216. - Pubmed
DTHybrid score	0.176
Succinate semialdehyde dehydrogenase, mitochondrial
Name	Succinate semialdehyde dehydrogenase, mitochondrial
Gene Name	ALDH5A1
Pharmacological action	unknown
Actions	inhibitor
References	Johannessen CU, Johannessen SI: Valproate: past, present, and future. CNS Drug Rev. 2003 Summer;9(2):199-216. - Pubmed
DTHybrid score	0.3485

Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.491
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5261
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9187
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5446
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.7354
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6917
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3455
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7329
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6897
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.0411
UDP-glucuronosyltransferase 1-4
Name	UDP-glucuronosyltransferase 1-4
Gene Name	UGT1A4
Actions	substrate
References	Argikar UA, Remmel RP: Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36. doi: 10.1124/dmd.108.022426. Epub 2008 Oct 6. - Pubmed
DTHybrid score	0.3035
UDP-glucuronosyltransferase 1-8
Name	UDP-glucuronosyltransferase 1-8
Gene Name	UGT1A8
Actions	substrate
References	Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, Court MH: UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. Epub 2005 Mar 10. - Pubmed
DTHybrid score	0.2993
UDP-glucuronosyltransferase 1-10
Name	UDP-glucuronosyltransferase 1-10
Gene Name	UGT1A10
Actions	substrate
References	Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, Court MH: UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. Epub 2005 Mar 10. - Pubmed
DTHybrid score	0.2983
UDP-glucuronosyltransferase 1-6
Name	UDP-glucuronosyltransferase 1-6
Gene Name	Not Available
Actions	substrate
References	Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, Court MH: UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. Epub 2005 Mar 10. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-3
Name	UDP-glucuronosyltransferase 1-3
Gene Name	UGT1A3
Actions	substrate
References	Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, Court MH: UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. Epub 2005 Mar 10. - Pubmed Argikar UA, Remmel RP: Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36. doi: 10.1124/dmd.108.022426. Epub 2008 Oct 6. - Pubmed Chung JY, Cho JY, Yu KS, Kim JR, Lim KS, Sohn DR, Shin SG, Jang IJ: Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600. Epub 2007 Aug 8. - Pubmed
DTHybrid score	0.4433
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Chung JY, Cho JY, Yu KS, Kim JR, Lim KS, Sohn DR, Shin SG, Jang IJ: Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600. Epub 2007 Aug 8. - Pubmed
DTHybrid score	0.4404
UDP-glucuronosyltransferase 2B15
Name	UDP-glucuronosyltransferase 2B15
Gene Name	Not Available
Actions	substrate
References	Chung JY, Cho JY, Yu KS, Kim JR, Lim KS, Sohn DR, Shin SG, Jang IJ: Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600. Epub 2007 Aug 8. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5085

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Jul 25;272(30):18526-9. - Pubmed
DTHybrid score	0.6256
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score	0.3444
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate,inhibitor
References	Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score	0.4392
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	substrate
References	Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. - Pubmed
DTHybrid score	0.3503
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate
References	Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed
DTHybrid score	0.3201

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.5253
1588	Multidrug resistance protein 1	ABCB1	0.5111
290	Prostaglandin G/H synthase 2	PTGS2	0.3478
6107	Cytochrome P450 3A7	CYP3A7	0.3324
587	Serum albumin	ALB	0.3298
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.2937
6013	Cytochrome P450 2E1	CYP2E1	0.2757
6024	Cytochrome P450 1A1	CYP1A1	0.2395
1024	Solute carrier family 22 member 11	SLC22A11	0.2095
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1989
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1852
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1842
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1546
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1358
489	Monocarboxylate transporter 2	SLC16A7	0.1343
862	Multidrug resistance-associated protein 1	ABCC1	0.1299
558	Solute carrier family 12 member 1	SLC12A1	0.1285
701	Isoleucine-tRNA synthetase	IARS	0.1263
4080	Isoleucyl-tRNA synthetase, mitochondrial	IARS2	0.1263
546	Isoleucyl-tRNA synthetase, cytoplasmic	IARS	0.1262
2164	Multidrug resistance-associated protein 4	ABCC4	0.1258
6145	Solute carrier family 22 member 1	SLC22A1	0.1245
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1139
6144	Solute carrier family 22 member 2	SLC22A2	0.1118
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0993
492	Histamine H1 receptor	HRH1	0.0979
3811	Cytochrome P450 19A1	CYP19A1	0.0977
500	Monocarboxylate transporter 4	SLC16A3	0.0972
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.097
776	Bile salt export pump	ABCB11	0.0906
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0905
833	Organic cation/carnitine transporter 1	SLC22A4	0.0881
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0833
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0826
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0816
6151	Monocarboxylate transporter 10	SLC16A10	0.0813
1898	Cytochrome P450 1B1	CYP1B1	0.0809
824	Sodium-dependent serotonin transporter	SLC6A4	0.0775
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0769
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0763
847	Mu-type opioid receptor	OPRM1	0.0729
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.072
467	Delta-type opioid receptor	OPRD1	0.0698
6102	Arylamine N-acetyltransferase 2	NAT2	0.0698
4604	Liver carboxylesterase 1	CES1	0.0693
696	Kappa-type opioid receptor	OPRK1	0.0662
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.065
6147	Solute carrier family 22 member 3	SLC22A3	0.0647
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0633
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0627
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0625
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0625
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0624
556	Alpha-1A adrenergic receptor	ADRA1A	0.0613
831	D(2) dopamine receptor	DRD2	0.0605
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0588
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0588
70	Type-1 angiotensin II receptor	AGTR1	0.0581
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.058
275	Arachidonate 5-lipoxygenase	ALOX5	0.0578
6031	Cytochrome P450 3A43	CYP3A43	0.0578
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0564
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0553
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0548
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0545
468	Cytochrome P450 4A11	CYP4A11	0.053
6136	Multidrug resistance-associated protein 5	ABCC5	0.0528
51	Muscarinic acetylcholine receptor M3	CHRM3	0.052
817	DNA topoisomerase 2-alpha	TOP2A	0.052
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0516
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0508
404	DNA gyrase subunit A	gyrA	0.0501
6224	DNA gyrase subunit A	gyrA	0.0501
6141	Sodium/bile acid cotransporter	SLC10A1	0.049
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0485
373	Transthyretin	TTR	0.0477
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0477
3941	Amine oxidase [flavin-containing] A	MAOA	0.0477
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0472
136	Estrogen receptor	ESR1	0.0471
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0469
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0467
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0462
318	Alpha-2A adrenergic receptor	ADRA2A	0.0458
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0454
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0447
338	DNA polymerase	UL30	0.0446
379	DNA polymerase	UL54	0.0446
697	DNA polymerase	ORF28	0.0446
2482	DNA polymerase	43	0.0446
4104	DNA polymerase	BALF5	0.0446
1757	Myeloperoxidase	MPO	0.0444
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0438
267	Plasminogen activator inhibitor 1	SERPINE1	0.0431
477	DNA topoisomerase 4 subunit A	parC	0.0431
886	DNA topoisomerase 4 subunit A	parC	0.0431
6226	DNA topoisomerase 4 subunit A	parC	0.0431
341	5-hydroxytryptamine 3 receptor	HTR3A	0.043
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0427
713	Sodium-dependent dopamine transporter	SLC6A3	0.042
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0417
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0417
3947	Xanthine dehydrogenase/oxidase	XDH	0.0408
465	Calmodulin	CALM1	0.0407
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0398
723	Cytosolic phospholipase A2	PLA2G4A	0.0396
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0396
766	Beta-2 adrenergic receptor	ADRB2	0.0393
6221	Steroid hormone receptor ERR1	ESRRA	0.0392
23	D(1A) dopamine receptor	DRD1	0.0392
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0391
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.039
459	Retinoic acid receptor RXR-alpha	RXRA	0.039
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.039
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0388
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0387
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0386
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0385
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0372
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.037
260	Cytochrome P450 51	ERG11	0.0368
761	Cytochrome P450 51	ERG11	0.0368
3163	Cytochrome P450 51	cyp51	0.0368
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0366
632	Alpha-1B adrenergic receptor	ADRA1B	0.0366
3809	Estrogen-related receptor gamma	ESRRG	0.0364
3939	Amine oxidase [flavin-containing] B	MAOB	0.0363
6020	Aldehyde oxidase	AOX1	0.0362
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0358
871	Glucocorticoid receptor	NR3C1	0.0347
731	HIV-1 protease	HIV-1 protease	0.0347
3810	Catechol O-methyltransferase	COMT	0.0338
6137	Multidrug resistance-associated protein 6	ABCC6	0.0337
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0337
6148	Multidrug resistance-associated protein 7	ABCC10	0.0334
856	Vitamin D3 receptor	VDR	0.033
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0328
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0327
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.032
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0319
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0314
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0312
124	Histamine H2 receptor	HRH2	0.031
3923	Cholinesterase	BCHE	0.0309
735	Alanine aminotransferase 1	GPT	0.0306
3904	Alanine aminotransferase 2	GPT2	0.0306
6014	Cytochrome P450 2A13	CYP2A13	0.0304
638	D(3) dopamine receptor	DRD3	0.0302
811	Translocator protein	TSPO	0.0301
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0296
1192	Sulfotransferase 1A1	SULT1A1	0.0296
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0296
146	Androgen receptor	AR	0.0296
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0295
629	Alpha-2B adrenergic receptor	ADRA2B	0.0295
891	Dihydropteroate synthase	folP	0.0294
5359	Dihydropteroate synthase	folP	0.0294
7175	Dihydropteroate synthase	sulI	0.0294
140	30S ribosomal protein S9	rpsI	0.0293
6719	30S ribosomal protein S9	rpsI	0.0293
6725	30S ribosomal protein S9	rpsI	0.0293
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0292
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0289
645	Penicillin-binding protein 1A	mrcA	0.0289
5805	Penicillin-binding protein 1A	ponA	0.0289
6185	Penicillin-binding protein 1A	mrcA	0.0289
6799	Penicillin-binding protein 1A	pbpA	0.0289
789	Alpha-1D adrenergic receptor	ADRA1D	0.0287
22	30S ribosomal protein S4	rpsD	0.0286
6714	30S ribosomal protein S4	rpsD	0.0286
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0282
380	Cytochrome P450 17A1	CYP17A1	0.0281
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.028
6149	Solute carrier family 22 member 10	SLC22A10	0.0276
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0273
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0272
193	Beta-1 adrenergic receptor	ADRB1	0.0267
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0263
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0263
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0263
122	P2Y purinoceptor 12	P2RY12	0.0263
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0262
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0261
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0261
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0261
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0261
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0261
36	Insulin receptor	INSR	0.0258
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0258
378	Alpha-2C adrenergic receptor	ADRA2C	0.0258
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0255
2929	(S)-2-haloacid dehalogenase	dhlB	0.0248
2995	(S)-2-haloacid dehalogenase	Not Available	0.0248
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0243
5880	Thrombopoietin receptor	MPL	0.0241
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0238
6220	Aryl hydrocarbon receptor	AHR	0.0236
4122	Histone deacetylase 2	HDAC2	0.0236
295	Carbonic anhydrase 1	CA1	0.0236
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0235
592	Carbonic anhydrase 4	CA4	0.0231
725	5-hydroxytryptamine 1D receptor	HTR1D	0.023
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0229
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0228
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0227
844	Epidermal growth factor receptor	EGFR	0.0226
6182	Cytochrome P450 2J2	CYP2J2	0.0224
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0224
6085	Fatty acid-binding protein, intestinal	FABP2	0.0222
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0222
357	Carbonic anhydrase 2	CA2	0.0217
543	Penicillin-binding protein 1B	mrcB	0.0215
6186	Penicillin-binding protein 1B	ponB	0.0215
6822	Penicillin-binding protein 1b	pbp1b	0.0215
6844	Penicillin-binding protein 1b	pbp1b	0.0215
1275	Estrogen sulfotransferase	SULT1E1	0.0215
504	Mast/stem cell growth factor receptor	KIT	0.0214
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0213
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0213
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0212
716	5-hydroxytryptamine 7 receptor	HTR7	0.0211
273	Apoptosis regulator Bcl-2	BCL2	0.0209
432	D(4) dopamine receptor	DRD4	0.0209
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0205
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0204
1050	Bile salt sulfotransferase	SULT2A1	0.0204
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0204
818	50S ribosomal protein L10	rplJ	0.0203
756	Sex hormone-binding globulin	SHBG	0.02
2016	Dipeptidase 1	DPEP1	0.0197
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0196
6859	Protein S100-A4	S100A4	0.0194
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0194
6500	Phospholipase A2	PLA2G1B	0.0194
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0193
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0193
1507	Cytochrome c	CYCS	0.0191
869	Estrogen receptor beta	ESR2	0.0191
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.019
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
6012	Tryptophan 2,3-dioxygenase	TDO2	0.019
16	Adenosine A1 receptor	ADORA1	0.0189
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0188
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0186
26	Vascular endothelial growth factor receptor 3	FLT4	0.0185
705	Glutamate receptor 1	GRIA1	0.0185
397	Monocarboxylate transporter 3	SLC16A8	0.0184
195	Monocarboxylate transporter 7	SLC16A6	0.0184
218	Monocarboxylate transporter 5	SLC16A4	0.0184
429	Monocarboxylate transporter 6	SLC16A5	0.0184
6043	Putative G-protein coupled receptor 44	GPR44	0.0184
3937	Fatty-acid amide hydrolase	FAAH	0.0183
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0183
54	Prothrombin	F2	0.0181
1	Peptidoglycan synthetase ftsI	ftsI	0.0179
4155	Peptidoglycan synthetase ftsI	ftsI	0.0179
407	Vascular endothelial growth factor receptor 2	KDR	0.0179
3913	Glutamic acid decarboxylase	GAD65	0.0179
5353	Glutamate decarboxylase alpha	gadA	0.0178
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0178
32	Vascular endothelial growth factor receptor 1	FLT1	0.0177
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0175
1178	Adenosine A2a receptor	ADORA2A	0.0174
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0173
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0173
777	Tumor necrosis factor	TNF	0.0172
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0172
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0172
3233	Bile acid receptor	NR1H4	0.0171
3639	Thymidine phosphorylase	deoA	0.0171
3936	Thymidine phosphorylase	TYMP	0.0171
2021	Thrombomodulin	THBD	0.0169
365	Dihydrofolate reductase	DHFR	0.0168
2381	Dihydrofolate reductase	DFR1	0.0168
2833	Dihydrofolate reductase	Not Available	0.0168
2931	Dihydrofolate reductase	folA	0.0168
3544	Dihydrofolate reductase	folA	0.0168
3682	Dihydrofolate reductase	folA	0.0168
6642	Dihydrofolate reductase	folA	0.0168
6756	Dihydrofolate reductase	dfrA	0.0168
737	Mineralocorticoid receptor	NR3C2	0.0168
2320	Thymidine kinase, cytosolic	TK1	0.0168
24	Thymidylate synthase	TMP1	0.0166
359	Thymidylate synthase	TYMS	0.0166
2626	Thymidylate synthase	thyA	0.0166
2729	Thymidylate synthase	thyA	0.0166
5352	Thymidylate synthase	THYA	0.0166
1483	Membrane copper amine oxidase	AOC3	0.0166
614	Progesterone receptor	PGR	0.0165
921	Glutamate receptor 2	GRIA2	0.0164
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0164
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0164
1410	Oxidoreductase	HSD17B6	0.0164
4725	Oxidoreductase	Not Available	0.0164
5124	Oxidoreductase	Not Available	0.0164
4007	Succinate receptor 1	SUCNR1	0.0164
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0164
673	Solute carrier family 13 member 3	SLC13A3	0.0164
25	Solute carrier family 13 member 1	SLC13A1	0.0163
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0163
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0163
498	Solute carrier family 13 member 2	SLC13A2	0.0163
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0162
4237	50S ribosomal protein L22	rplV	0.0161
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0161
952	Dipeptidyl peptidase 4	DPP4	0.0161
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.016
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.016
1629	Transcription factor AP-1	JUN	0.016
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3179	2-isopropylmalate synthase	leuA	0.0159
232	Corticosteroid-binding globulin	SERPINA6	0.0159
199	Monocarboxylate transporter 8	SLC16A2	0.0158
117	Sterol O-acyltransferase 1	SOAT1	0.0158
3426	Glutamine synthetase	glnA	0.0157
3987	Glutamine synthetase	GLUL	0.0157
427	Substance-P receptor	TACR1	0.0157
860	Nicotinamide N-methyltransferase	NNMT	0.0157
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0157
928	Nicotinic acid receptor 2	GPR109B	0.0157
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0157
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0157
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0157
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0157
699	Nicotinic acid receptor 1	GPR109A	0.0157
85	Growth hormone receptor	GHR	0.0156
532	Neutral amino acid transporter A	SLC1A4	0.0156
323	Alanyl-tRNA synthetase, cytoplasmic	AARS	0.0156
4070	Probable alanyl-tRNA synthetase, mitochondrial	AARS2	0.0156
52	Pyruvate kinase isozymes R/L	PKLR	0.0156
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0155
4238	50S ribosomal protein L4	rplD	0.0155
5578	50S ribosomal protein L4	rplD	0.0155
6173	50S ribosomal protein L4	rplD	0.0155
6219	50S ribosomal protein L4	rplD	0.0155
6174	50S ribosomal protein L32	rpmF	0.0155
4217	Telomerase reverse transcriptase	TERT	0.0154
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0154
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0153
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0152
3899	Alanine--glyoxylate aminotransferase 2-like 2	AGXT2L2	0.0151
6138	Multidrug resistance protein 3	ABCB4	0.0151
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0151
1630	Integrin beta-2	ITGB2	0.015
6033	High affinity interleukin-8 receptor A	CXCR1	0.015
771	Pyruvate carboxylase, mitochondrial	PC	0.015
3917	Methylenetetrahydrofolate reductase	MTHFR	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0149
29	Tubulin beta-1 chain	TUBB1	0.0149
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0149
482	Glycine receptor subunit alpha-1	GLRA1	0.0148
183	Vascular endothelial growth factor A	VEGFA	0.0147
527	Prostacyclin receptor	PTGIR	0.0146
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
1867	Major prion protein	PRNP	0.0144
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0143
435	Kynureninase	KYNU	0.0143
4654	Kynureninase	kynU	0.0143
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0142
169	Cysteine desulfurase, mitochondrial	NFS1	0.0142
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0142
5650	NimA-related protein	DR_0842	0.0142
6103	Arylamine N-acetyltransferase 1	NAT1	0.0141
1010	Cytochrome P450 51A1	CYP51A1	0.0141
5626	Nucleoside diphosphate kinase B	NME2	0.0139
6044	Serum paraoxonase/lactonase 3	PON3	0.0139
571	Melatonin receptor type 1A	MTNR1A	0.0138
362	Melatonin receptor type 1B	MTNR1B	0.0138
33	Cystine/glutamate transporter	SLC7A11	0.0138
94	5-hydroxytryptamine 4 receptor	HTR4	0.0138
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0138
332	Beta-lactamase	blaZ	0.0138
2478	Beta-lactamase	ampC	0.0138
2613	Beta-lactamase	ampC	0.0138
2635	Beta-lactamase	ampC	0.0138
2700	Beta-lactamase	penP	0.0138
5445	Beta-lactamase	blaB	0.0138
6019	Beta-lactamase	SHV-7	0.0138
6701	Beta-lactamase	cphA	0.0138
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0138
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0136
569	Retinal dehydrogenase 2	ALDH1A2	0.0136
4120	NADPH--cytochrome P450 reductase	POR	0.0135
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0134
6126	Carbonic anhydrase 7	CA7	0.0133
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0133
130	Prostacyclin synthase	PTGIS	0.0133
6167	Organic solute transporter subunit beta	OSTB	0.0132
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0132
6166	Organic solute transporter subunit alpha	OSTA	0.0132
131	Synaptic vesicular amine transporter	SLC18A2	0.0132
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0132
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0131
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0131
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0131
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0131
1760	Aminopeptidase N	ANPEP	0.0131
6843	Aminopeptidase N	pepN	0.0131
251	Alcohol dehydrogenase 1A	ADH1A	0.0131
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.013
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.013
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0129
3932	Glutathione S-transferase A2	GSTA2	0.0128
3685	Catabolite gene activator	crp	0.0127
4655	Adenylate cyclase	cyaC	0.0127
4759	Adenylate cyclase	cyaB2	0.0127
3334	Deacetoxycephalosporin C synthetase	cefE	0.0127
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0127
611	Retinal dehydrogenase 1	ALDH1A1	0.0127
823	Fibroblast growth factor receptor 2	FGFR2	0.0127
1656	CYP2B protein	CYP2B	0.0126
6207	30S ribosomal protein S14	rpsN	0.0124
6209	30S ribosomal protein S19	rpsS	0.0124
6712	30S ribosomal protein S19	rpsS	0.0124
6726	30S ribosomal protein S19	rpsS	0.0124
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0124
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0123
474	Acetylcholinesterase	ACHE	0.0123
349	Serine--pyruvate aminotransferase	AGXT	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
438	Taste receptor type 1 member 2	TAS1R2	0.0122
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.0122
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.0122
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.0122
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0121
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0119
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
84	Nuclear receptor 0B1	NR0B1	0.0119
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0118
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0118
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0118
1792	Tissue-type plasminogen activator	PLAT	0.0117
444	Alcohol dehydrogenase 1B	ADH1B	0.0116
3808	Dihydropteroate synthase 2	folP2	0.0116
3601	Dihydropteroate synthase 1	folP1	0.0116
3807	Dihydropteroate synthase 1	folP1	0.0116
6218	Pannexin-1	PANX1	0.0116
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0116
517	Alcohol dehydrogenase 1C	ADH1C	0.0115
7	Nitric oxide synthase, inducible	NOS2	0.0115
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0114
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0114
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0114
5294	Nucleoside diphosphate kinase A	NME1	0.0113
88	Retinoic acid receptor RXR-beta	RXRB	0.0112
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0112
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
3686	Acyl-CoA thioesterase I precursor	tesA	0.0111
68	Cannabinoid receptor 1	CNR1	0.0111
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.011
2249	Aspartate aminotransferase	aspC	0.011
2671	Aspartate aminotransferase	aspC	0.011
5490	Aspartate aminotransferase	Not Available	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.011
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.011
4760	Mll3241 protein	mll3241	0.0109
1636	Trace amine-associated receptor 1	TAAR1	0.0109
6432	Transporter	snf	0.0108
244	Angiotensin-converting enzyme	ACE	0.0108
1618	High affinity nerve growth factor receptor	NTRK1	0.0108
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0107
6042	Prostaglandin reductase 2	PTGR2	0.0107
164	Histamine H4 receptor	HRH4	0.0107
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0105
174	Sigma 1-type opioid receptor	SIGMAR1	0.0105
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0105
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0105
1650	Heme carrier protein 1	SLC46A1	0.0103
572	Integrin alpha-L	ITGAL	0.0103
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0103
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
518	Peroxidase/catalase T	katG	0.01
624	Guanidinoacetate N-methyltransferase	GAMT	0.01
780	Retinoic acid receptor RXR-gamma	RXRG	0.01
284	DNA-directed RNA polymerase beta chain	rpoB	0.01
5773	DNA-directed RNA polymerase beta chain	rpoB	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0099
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0099
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0099
887	DNA gyrase subunit B	gyrB	0.0099
4150	DNA gyrase subunit B	gyrB	0.0099
6225	DNA gyrase subunit B	gyrB	0.0099
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0098
1648	Elastin	ELN	0.0098
672	Prostaglandin F2-alpha receptor	PTGFR	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
161	Tubulin beta chain	TUBB	0.0096
312	Tubulin beta chain	TUB2	0.0096
49	Endothelin B receptor	EDNRB	0.0096
65	Matrix metalloproteinase-9	Not Available	0.0095
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
4203	Histamine N-methyltransferase	HNMT	0.0093
867	Penicillin-binding protein 3	pbpC	0.0092
6119	Penicillin-binding protein 3	pbp3	0.0092
7154	Penicillin-binding protein 3	pbp3	0.0092
7157	Penicillin-binding protein 3	LMHCC_2184	0.0092
7162	Penicillin-binding protein 3	pbpB	0.0092
7172	Penicillin-binding protein 3	pbp3	0.0092
4773	Deoxycytidine kinase	DCK	0.0092
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0091
1654	Interleukin-1 beta	IL1B	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.009
165	FL cytokine receptor	FLT3	0.009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0089
6010	Thiamine transporter 1	SLC19A2	0.0089
770	Retinoic acid-induced protein 3	GPRC5A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
163	D(1B) dopamine receptor	DRD5	0.0088
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0088
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0088
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0088
563	Thyroid peroxidase	TPO	0.0087
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0087
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0087
162	Retinoic acid receptor gamma-1	RARG	0.0086
3014	Ribonuclease UK114	HRSP12	0.0086
5428	Replication protein	repA	0.0086
3617	Non-heme chloroperoxidase	cpo	0.0086
5426	Non-heme chloroperoxidase	cpo	0.0086
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0086
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0086
3018	HTH-type transcriptional regulator malT	malT	0.0086
3312	Fatty acid-binding protein, brain	FABP7	0.0086
106	Cannabinoid receptor 2	CNR2	0.0086
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0084
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0084
53	Solute carrier family 12 member 5	SLC12A5	0.0084
663	Solute carrier family 12 member 4	SLC12A4	0.0084
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0084
714	Glutathione reductase, mitochondrial	GSR	0.0083
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
2472	Voltage-gated potassium channel	kcsA	0.0083
6366	Voltage-gated potassium channel	kcsA	0.0083
1313	Lactoylglutathione lyase	GLO1	0.0082
239	Coagulation factor X	F10	0.0082
2539	Tubulin alpha-1 chain	TUBA4A	0.0082
634	Squalene monooxygenase	SQLE	0.0082
7196	Squalene monooxygenase	ERG1	0.0082
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0082
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0082
185	Vasopressin V1a receptor	AVPR1A	0.0082
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0081
1196	Complement decay-accelerating factor	CD55	0.0081
2230	Catalase	CAT	0.008
3249	Catalase	katA	0.008
3625	Catalase	katA	0.008
4539	Catalase	katA	0.008
4941	Catalase	katB	0.008
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.008
175	Thiamin pyrophosphokinase 1	TPK1	0.008
564	Cellular retinoic acid-binding protein 1	CRABP1	0.008
5300	Antigen peptide transporter 1	TAP1	0.008
153	Dopamine beta-hydroxylase	DBH	0.008
322	Vasopressin V2 receptor	AVPR2	0.008
293	Gamma-glutamyl hydrolase	GGH	0.008
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.008
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.008
816	Biliverdin reductase A	BLVRA	0.008
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0079
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0079
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0079
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0079
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0079
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0079
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0079
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0079
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0079
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0079
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0079
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0079
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0079
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0079
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0079
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0079
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0079
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0079
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0079
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0079
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0079
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0079
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0079
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0079
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0079
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0079
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0079
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0079
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0079
644	Heme oxygenase 2	HMOX2	0.0079
4982	Heme oxygenase 2	pbsA2	0.0079
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0079
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0079
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0079
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0079
107	C-4 methylsterol oxidase	SC4MOL	0.0079
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0079
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0079
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0079
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0079
167	L-lactate dehydrogenase C chain	LDHC	0.0079
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0079
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0079
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0079
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0079
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0079
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0079
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0079
729	GDP-L-fucose synthetase	TSTA3	0.0079
3463	GDP-L-fucose synthetase	fcl	0.0079
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0079
206	3-keto-steroid reductase	HSD17B7	0.0079
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0079
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0079
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0079
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0079
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0079
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0079
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0079
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0079
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0079
34	7-dehydrocholesterol reductase	DHCR7	0.0079
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0079
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0079
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0079
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0079
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0079
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0079
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0079
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0079
711	UDP-glucose 6-dehydrogenase	UGDH	0.0079
3672	UDP-glucose 6-dehydrogenase	hasB	0.0079
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0079
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0079
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0079
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0079
643	Peroxisomal bifunctional enzyme	EHHADH	0.0079
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0079
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0079
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0079
310	Solute carrier family 12 member 2	SLC12A2	0.0078
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0078
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0078
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0077
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0077
3587	Gastrotropin	FABP6	0.0077
4226	Uridine phosphorylase 2	UPP2	0.0076
654	Flavin reductase	BLVRB	0.0076
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0076
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0075
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0075
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0075
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0074
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0074
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0074
1541	Metalloproteinase	mmp20	0.0074
2958	Probable tautomerase ydcE	pptA	0.0074
1852	Microtubule-associated protein 2	MAP2	0.0074
2573	Cocaine esterase	cocE	0.0074
7263	Cocaine esterase	Not Available	0.0074
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0073
494	Caspase-1	CASP1	0.0073
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0073
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0073
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0073
976	Platelet glycoprotein IX	GP9	0.0073
3115	Ras-related protein Rab-9	RAB9A	0.0073
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0072
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0072
5787	Angiopoietin-1 receptor	TEK	0.0071
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0071
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0071
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0071
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0071
5818	Folate receptor alpha	FOLR1	0.007
2808	Chloramphenicol acetyltransferase 3	cat3	0.007
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.007
4225	Uridine phosphorylase 1	UPP1	0.0069
822	Aldose reductase	AKR1B1	0.0069
5924	Microtubule-associated protein 4	MAP4	0.0069
5923	Microtubule-associated protein tau	MAPT	0.0069
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0069
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0068
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0068
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0068
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0068
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0068
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0068
936	Ephrin type-A receptor 2	EPHA2	0.0068
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0068
6837	Serine/threonine-protein kinase 17B	STK17B	0.0067
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0067
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0067
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0067
6131	Carbonic anhydrase 14	CA14	0.0067
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0067
1517	Beta-3 adrenergic receptor	ADRB3	0.0067
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0067
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0067
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0067
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0067
469	Annexin A1	ANXA1	0.0066
3760	Penicillin-binding protein 5 precursor	dacA	0.0066
597	Dihydropteridine reductase	QDPR	0.0066
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0066
666	NADP-dependent malic enzyme	ME1	0.0066
413	Amidophosphoribosyltransferase	PPAT	0.0066
2515	Amidophosphoribosyltransferase	purF	0.0066
3714	Amidophosphoribosyltransferase	purF	0.0066
328	Sorbitol dehydrogenase	SORD	0.0065
5798	Mitogen-activated protein kinase 11	MAPK11	0.0065
396	Alcohol dehydrogenase 4	ADH4	0.0065
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0065
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0065
814	Ryanodine receptor 1	RYR1	0.0065
626	Cysteine dioxygenase type 1	CDO1	0.0065
6146	High affinity copper uptake protein 1	SLC31A1	0.0065
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0064
2417	Chloramphenicol acetyltransferase	cat	0.0064
3278	Chloramphenicol acetyltransferase	cat	0.0064
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0064
857	Malate dehydrogenase, mitochondrial	MDH2	0.0064
4311	tRNA	TRDMT1	0.0064
4325	tRNA	trmD	0.0064
4328	tRNA	trmD	0.0064
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0064
2810	Dr hemagglutinin structural subunit	draA	0.0064
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0063
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
473	L-lactate dehydrogenase A chain	LDHA	0.0063
6026	Alcohol dehydrogenase 6	ADH6	0.0063
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0063
5126	Arginase	rocF	0.0063
133	Dihydropterate synthase	sulI	0.0063
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0062
1353	DNA topoisomerase 1	TOP1	0.0062
3552	DNA topoisomerase 1	topA	0.0062
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
2077	Caspase-3	CASP3	0.0061
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0061
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0061
627	11-cis retinol dehydrogenase	RDH5	0.0061
1405	Thiopurine S-methyltransferase	TPMT	0.0061
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0061
665	Phosphoserine aminotransferase	PSAT1	0.0061
4652	Phosphoserine aminotransferase	serC	0.0061
420	Glutamate decarboxylase 1	GAD1	0.0061
3900	Glutamate decarboxylase 1	GAD1	0.0061
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0061
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0061
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
77	L-lactate dehydrogenase B chain	LDHB	0.006
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0059
828	Phenylalanine-4-hydroxylase	PAH	0.0059
3109	Phenylalanine-4-hydroxylase	phhA	0.0059
12	Alcohol dehydrogenase class 3	ADH5	0.0059
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0059
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0059
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0059
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0059
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0059
904	Glutathione S-transferase P	GSTP1	0.0059
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0059
819	Penicillin-binding protein 4	dacB	0.0059
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0059
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0059
6168	Solute carrier family 22 member 16	SLC22A16	0.0058
581	Cytochrome P450 2R1	CYP2R1	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
2599	Tyrosine-protein kinase HCK	HCK	0.0058
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0057
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
788	Creatine kinase M-type	CKM	0.0057
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0057
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0057
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0057
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0057
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0057
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0057
13	Aminomethyltransferase, mitochondrial	AMT	0.0056
3877	Growth-inhibiting protein 18	GIG18	0.0056
703	NADPH azoreductase	azr	0.0056
499	Arginine decarboxylase	ADC	0.0056
751	Potassium channel subfamily K member 6	KCNK6	0.0056
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0056
1714	Mitogen-activated protein kinase 3	MAPK3	0.0056
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0056
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0056
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0056
2693	Heat-labile enterotoxin B chain	eltB	0.0056
319	Opioid receptor, sigma 1	OPRS1	0.0055
6645	D-amino-acid oxidase	DAO	0.0055
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
594	Thyroxine-binding globulin	SERPINA7	0.0054
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0054
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0054
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0054
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0054
763	Tyrosine aminotransferase	TAT	0.0054
5493	Tyrosine aminotransferase	Not Available	0.0054
3086	Plasmepsin-2	Not Available	0.0053
810	Heme oxygenase 1	HMOX1	0.0053
3391	Heme oxygenase 1	pbsA1	0.0053
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0053
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0053
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0053
5934	Cytochrome P450 26A1	CYP26A1	0.0053
3957	Adenosine deaminase	ADA	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
268	Adenosine A2b receptor	ADORA2B	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
4103	Proteasome subunit beta type 2	PSMB2	0.0053
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0053
4102	Proteasome subunit beta type 5	PSMB5	0.0053
4101	Proteasome subunit beta type 1	PSMB1	0.0053
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0052
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0052
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0052
712	Tubulin alpha chain	TUB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
291	Nitric-oxide synthase, endothelial	NOS3	0.0052
172	Potassium channel subfamily K member 1	KCNK1	0.0052
279	Tyrosinase	TYR	0.0052
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0052
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
2300	Lysozyme	E	0.0051
3633	Lysozyme	R	0.0051
5597	Lysozyme	17	0.0051
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.005
768	FK506-binding protein 1A	FKBP1A	0.005
758	Thyroid hormone receptor alpha	THRA	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
1198	Serum paraoxonase/arylesterase 1	PON1	0.005
6223	Penicillin-binding protein 1C	pbpC	0.005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.005
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0049
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0049
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
4192	DNA topoisomerase 2-beta	TOP2B	0.0049
1341	Histamine H3 receptor	HRH3	0.0048
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0048
551	Carnitine O-acetyltransferase	CRAT	0.0047
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0047
3830	Calreticulin	CALR	0.0047
2298	Cytochrome P450-cam	camC	0.0046
908	Glutathione S-transferase theta-1	GSTT1	0.0046
173	Toll-like receptor 7	TLR7	0.0046
1992	Vitamin D-binding protein	GC	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
2207	Rhodopsin	RHO	0.0045
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0045
6122	Carbonic anhydrase 3	CA3	0.0045
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0044
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0044
4026	Aspartyl aminopeptidase	DNPEP	0.0044
4019	Excitatory amino acid transporter 4	SLC1A6	0.0044
1047	Excitatory amino acid transporter 2	SLC1A2	0.0044
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0044
1912	Excitatory amino acid transporter 1	SLC1A3	0.0044
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0044
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0044
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0044
4016	Excitatory amino acid transporter 5	SLC1A7	0.0044
664	Glutamate decarboxylase 2	GAD2	0.0044
3890	Glutamate decarboxylase 2	GAD2	0.0044
922	Glutamate receptor 4	GRIA4	0.0044
927	Metabotropic glutamate receptor 8	GRM8	0.0044
4020	Glutamyl aminopeptidase	ENPEP	0.0044
4018	Glutamate receptor delta-2 subunit	GRID2	0.0044
925	Metabotropic glutamate receptor 4	GRM4	0.0044
926	Metabotropic glutamate receptor 7	GRM7	0.0044
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0044
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0044
4027	Glutamate receptor delta-1 subunit	GRID1	0.0044
4017	5-oxoprolinase	OPLAH	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0044
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0044
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0044
6034	Hydroxyindole O-methyltransferase	ASMT	0.0043
6035	Nuclear receptor ROR-beta	RORB	0.0043
6036	Eosinophil peroxidase	EPX	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0043
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0042
3856	Fibroblast growth factor receptor 3	FGFR3	0.0042
2112	Toll-like receptor 9	TLR9	0.0042
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0041
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0041
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0041
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0041
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0041
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0041
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
408	Riboflavin kinase	RFK	0.0041
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0041
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0041
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0041
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
5482	Sialidase-2	NEU2	0.0039
1864	RET proto-oncogene	RET	0.0039
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0039
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0039
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0038
2236	Casein kinase II subunit alpha	CSNK2A1	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0038
3007	Carbonic anhydrase 12	CA12	0.0038
765	Indoleamine 2,3-dioxygenase	IDO1	0.0038
625	Glutamate carboxypeptidase 2	FOLH1	0.0038
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0038
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0038
4205	Carbonic anhydrase 9	CA9	0.0038
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0038
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0038
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0038
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0038
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0038
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0038
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0037
5682	Ribonuclease pancreatic	RNASE1	0.0036
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0036
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0036
1262	Corticotropin-lipotropin	POMC	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
916	Metabotropic glutamate receptor 1	GRM1	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1671	Excitatory amino acid transporter 3	SLC1A1	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
1374	Natriuretic peptides B	NPPB	0.0034
1827	Gap junction alpha-1 protein	GJA1	0.0034
1908	Vascular cell adhesion protein 1	VCAM1	0.0034
820	Glycine receptor subunit alpha-2	GLRA2	0.0034
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0034
923	Glutamate receptor 3	GRIA3	0.0033
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0033
229	Retinoic acid receptor beta	RARB	0.0033
358	Cystathionine beta-synthase	CBS	0.0033
730	Retinoic acid receptor alpha	RARA	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0031
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0031
577	Argininosuccinate lyase	ASL	0.0031
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0031
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0031
1268	Neuropeptide S receptor	NPSR1	0.0031
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0031
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
2391	Ferrochelatase	hemH	0.0029
6502	Ferrochelatase	DKFZp686P18130	0.0029
1591	Ferrochelatase, mitochondrial	FECH	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
4252	Penicillin-binding protein 5	dacA	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
740	Argininosuccinate synthase	ASS1	0.0028
865	Argininosuccinate synthase	ASS1	0.0028
2680	Argininosuccinate synthase	argG	0.0028
3194	Argininosuccinate synthase	argG	0.0028
6073	Potassium channel subfamily K member 9	KCNK9	0.0028
6072	Potassium channel subfamily K member 3	KCNK3	0.0028
400	Coagulation factor IX	F9	0.0027
5461	Coagulation factor IX	F9	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6048	Troponin C, skeletal muscle	TNNC2	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3883	Ornithine aminotransferase variant	Not Available	0.0026
3896	CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase	GADL1	0.0026
3911	Uncharacterized protein C20orf38	SPTLC3	0.0026
3881	Selenocysteine lyase variant	Not Available	0.0026
3887	Phosphorylase	PYGB	0.0026
3915	Cysteine sulfinic acid decarboxylase-related protein 1	CSAD	0.0026
3914	Alanine-glyoxylate aminotransferase homolog	TLH6	0.0026
3878	GAD1 protein	GAD1	0.0026
6171	Solute carrier family 28 member 3	SLC28A3	0.0026
306	Pyridoxal phosphate phosphatase	PDXP	0.0026
3906	Serine dehydratase-like	SDSL	0.0026
3891	Putative L-Dopa decarboxylase	DDC	0.0026
3903	Aminolevulinate, delta-, synthase 2	ALAS2	0.0026
3880	Serine hydroxymethyltransferase 1	Not Available	0.0026
3908	P-selectin cytoplasmic tail-associated protein	pcap	0.0026
3893	DDC protein	DDC	0.0026
3910	O-phosphoseryl-tRNA(Sec) selenium transferase	SEPSECS	0.0026
855	Sphingosine-1-phosphate lyase 1	SGPL1	0.0026
3886	Migration-inducing protein 4	ALAS1	0.0026
3909	Hepatic peroxysomal alanine:glyoxylate aminotransferase	Not Available	0.0026
3894	KIAA0251 protein	PDXDC1	0.0026
3875	Glycogen phosphorylase, brain form	PYGB	0.0026
3882	Brain glycogen phosphorylase variant	Not Available	0.0026
3905	Molybdenum cofactor sulfurase	MOCOS	0.0026
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0026
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0026
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0026
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0025
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0025
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0025
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0025
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0025
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0025
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0025
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0025
6559	Cytochrome c oxidase subunit 2	ctaC	0.0025
6669	Cytochrome c oxidase subunit 2	ctaC	0.0025
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0025
6558	Cytochrome c oxidase subunit 1	ctaD	0.0025
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0025
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0025
604	Vitamin K-dependent protein Z	PROZ	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
727	Serine palmitoyltransferase 2	SPTLC2	0.0024
491	Serine palmitoyltransferase 1	SPTLC1	0.0024
89	Cysteine sulfinic acid decarboxylase	CSAD	0.0024
184	L-serine dehydratase	SDS	0.0024
431	Serine racemase	SRR	0.0024
3874	Proline synthetase co-transcribed bacterial homolog protein	PROSC	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
6824	Tyrosine-protein kinase Lyn	LYN	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
534	Threonine synthase-like 1	THNSL1	0.0024
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0024
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0024
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
3	Histidine decarboxylase	HDC	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
2540	Choloylglycine hydrolase	cbh	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2216	Fibroblast growth factor receptor 4	FGFR4	0.0023
1245	Vitamin K-dependent protein S	PROS1	0.0023
422	Vitamin K-dependent protein C	PROC	0.0023
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
472	Ornithine aminotransferase, mitochondrial	OAT	0.0022
6501	Fatty acid-binding protein, liver	FABP1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3884	SHMT2 protein	SHMT2	0.0022
3901	SHMT2 protein	SHMT2	0.0022
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0022
3879	Serine hydroxymethyltransferase 2	Not Available	0.0022
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0022
4948	Cytochrome c-553	Not Available	0.0022
4923	Cytochrome c3	DvMF_2499	0.0022
4945	Cytochrome c3	Not Available	0.0022
4949	Cytochrome c3	DVU_3171	0.0022
4968	Cytochrome c3	cytc3	0.0022
4997	Cytochrome c3	SO_2727	0.0022
5219	Cytochrome c3	cyd	0.0022
896	Glutathione S-transferase Mu 1	GSTM1	0.0022
4902	Nine-heme cytochrome c	Ddes_2038	0.0022
3189	High-molecular-weight cytochrome c	hmcA	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0021
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0021
6506	Stathmin-4	STMN4	0.0021
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
4954	Soluble cytochrome b558	Not Available	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
4934	Cytochrome c-551	nirM	0.0021
5218	Cytochrome c-551	nirM	0.0021
4925	Cytochrome c-type protein SHP	shp	0.0021
4905	Cytochrome c2	Not Available	0.0021
4939	Cytochrome c2	cycA	0.0021
4964	Cytochrome c2	cycA	0.0021
4979	Cytochrome c2	cycA	0.0021
6673	Cytochrome c2	cycA	0.0021
4915	Cytochrome c-550	psbV	0.0021
4959	Cytochrome c-550	psbV	0.0021
5216	Cytochrome c-550	psbV	0.0021
4947	Bacterial hemoglobin	vhb	0.0021
4943	Cytochrome c6	petJ	0.0021
4916	Cyanoglobin	glbN	0.0021
4975	Cytochrome c-556	RPA3973	0.0021
4984	Neuroglobin	NGB	0.0021
4998	Hemoglobin-like protein yjbI	yjbI	0.0021
4994	Hemoglobin-like protein HbO	glbO	0.0021
3116	Bacterioferritin	bfr	0.0021
4906	Bacterioferritin	bfr	0.0021
4965	Bacterioferritin	bfr	0.0021
4936	Cytochrome c2 iso-2	Not Available	0.0021
4907	Cytochrome c-L	moxG	0.0021
6865	Cytochrome c-L	moxG	0.0021
4909	CooA protein	cooA	0.0021
4942	Diheme cytochrome c napB	napB	0.0021
4981	Iron-starvation protein PigA	pigA	0.0021
4961	Hemophore HasA	hasA	0.0021
4910	Cytoglobin	CYGB	0.0021
5000	HemO	hemO	0.0021
4935	Cytochrome c-554	cycA1	0.0021
4971	Nonaheme cytochrome c	hmcA	0.0021
4976	Apocytochrome f	petA	0.0021
6407	Apocytochrome f	petA	0.0021
4904	Cytochrome c family protein	GSU1996	0.0021
4989	Cytochrome c551 peroxidase	ccp	0.0021
5222	Cytochrome c551 peroxidase	ccpA	0.0021
2091	Endoplasmin	HSP90B1	0.0021
4999	Cytochrome P450 165B3	CYP165B3	0.0021
4764	Cytochrome P450 165C4	CYP165C4	0.0021
4960	Putative cytochrome P450-family protein	SCO7417	0.0021
4931	Cytochrome P450 167A1	CYP167A1	0.0021
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0021
4937	Cytochrome oxidase subunit II	rcoxA	0.0021
4903	Methyl-accepting chemotaxis protein	Tar4	0.0021
4972	P450cin	cinA	0.0021
4993	Hydroxylamine oxidoreductase	hao1	0.0021
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0021
4922	Cytochrome c, putative	SO_4144	0.0021
4952	Catalase/peroxidase	katA	0.0021
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0021
3093	Catalase HPII	katE	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
868	Cystathionine gamma-lyase	CTH	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
301	Kynurenine--oxoglutarate transaminase 1	CCBL1	0.0021
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.002
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.002
769	High-affinity choline transporter 1	SLC5A7	0.002
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.002
861	Choline kinase alpha	CHKA	0.002
700	Choline dehydrogenase, mitochondrial	CHDH	0.002
3927	Choline transporter-like protein 3	SLC44A3	0.002
1686	Choline transporter-like protein 1	SLC44A1	0.002
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.002
3926	Choline transporter-like protein 2	SLC44A2	0.002
3925	Choline transporter-like protein 4	SLC44A4	0.002
576	Choline O-acetyltransferase	CHAT	0.002
3922	Phospholipase D2	PLD2	0.002
3924	Phospholipase D1	PLD1	0.002
1820	Beta-nerve growth factor	NGF	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
1243	Cathepsin D	CTSD	0.0019
1525	Heparin-binding growth factor 2	FGF2	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
10	Glycogen phosphorylase, liver form	PYGL	0.0019
449	Ornithine decarboxylase	ODC1	0.0019
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0019
798	Osteocalcin	BGLAP	0.0019
4386	Hemoglobin-like protein HbN	glbN	0.0018
1253	Interferon gamma	IFNG	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
683	Potassium transporter	GK0582	0.0018
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
6163	Copper-transporting ATPase 2	ATP7B	0.0017
6165	Copper-transporting ATPase 1	ATP7A	0.0017
369	Coagulation factor VII	F7	0.0017
3221	Cytochrome c4	cc4	0.0017
76	Nitric-oxide synthase, brain	NOS1	0.0017
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0016
4920	Peroxidase/catalase	katG	0.0016
2119	Cytochrome b5	CYB5A	0.0016
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0015
4990	PpcA	ppcA	0.0015
4988	Sulfite oxidase, mitochondrial	SUOX	0.0015
3375	Acidic cytochrome c3	Not Available	0.0015
4037	Hypothetical protein	GPX1	0.0015
4297	Hypothetical protein	SP_1951	0.0015
4521	Hypothetical protein	BC_2969	0.0015
4540	Hypothetical protein	TM_1070	0.0015
4555	Hypothetical protein	MT1739	0.0015
4569	Hypothetical protein	mshD	0.0015
4578	Hypothetical protein	PA3270	0.0015
4747	Hypothetical protein	PA3967	0.0015
5177	Hypothetical protein	TM_0096	0.0015
5194	Hypothetical protein	PA1204	0.0015
5240	Hypothetical protein	Rv2991	0.0015
5370	Hypothetical protein	TM_1158	0.0015
5710	Hypothetical protein	Tb927.5.1360	0.0015
2915	Sensor protein fixL	fixL	0.0015
4944	Sensor protein fixL	fixL	0.0015
3570	Cytochrome P450 152A1	cypC	0.0015
4385	Cytochrome c'	Not Available	0.0015
4967	Cytochrome c'	cycA	0.0015
5038	Cytochrome c'	Not Available	0.0015
5223	Cytochrome c'	cycP	0.0015
4992	Cytochrome c peroxidase	Not Available	0.0015
4289	Cytochrome P450	TT_P0059	0.0015
6262	Cytochrome P450	staP	0.0015
4813	Heme oxygenase	hmuO	0.0015
5769	Heme oxygenase	Not Available	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
760	Fibroblast growth factor 1	FGF1	0.0015
1152	Glycogen phosphorylase, muscle form	PYGM	0.0015
3670	Soluble cytochrome b562 precursor	cybC	0.0014
3411	Cytochrome P450 121	cyp121	0.0014
3291	Cytochrome c-552	cycA	0.0013
4927	Cytochrome c-552	nrfA	0.0013
4938	Cytochrome c-552	cycA	0.0013
4953	Cytochrome c-552	nrfA	0.0013
5217	Cytochrome c-552	cycM	0.0013
2617	Nitric oxide synthase oxygenase	nos	0.0013
2701	Nitric oxide synthase oxygenase	nos	0.0013
3102	Flavohemoprotein	hmp	0.0013
4969	Flavohemoprotein	hmp	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0012
1295	Fatty acid synthase	FASN	0.0012
702	UMP-CMP kinase	CMPK1	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
4608	Putative cytochrome P450	SCO1207	0.0011
4963	Putative cytochrome P450	SCO2884	0.0011
6254	Putative cytochrome P450	SCO6998	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
997	Protein kinase C beta type	PRKCB	0.001
693	Hemoglobin subunit beta	HBB	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
283	SEC14-like protein 2	SEC14L2	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6268	Hydroxyacid oxidase 1	HAO1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6677	Myelin P2 protein	PMP2	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
1184	Interferon beta	IFNB1	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00313 - Valproic Acid

Targets

Enzymes

Transporters

Predictions