DT-Web: DB01032

Identification

Name

Probenecid

Accession Number

DB01032 (APRD00167)

Type

small molecule

Description

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

285.359

Groups

approved

Monoisotopic Weight

285.103478791

Pharmacology

Indication

For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.

Mechanism of action

Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. The mechanism by which probenecid inhibits renal tubular transport is not known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interfere with substrate access to protein receptor sites on the kidney tubules.

Absorption

Not Available

Protein binding

75-95%

Biotransformation

Not Available

Route of elimination

Excreted principally in the urine as monoacyl glucuronide and unchanged drug. Alkalinization of urine increases renal probenecid excretion.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetylsalicylic acid	Acetylsalicylic acid decreases the uricosuric effect of probenecid.
Bismuth Subsalicylate	The salicylate, bismuth subsalicylate, decreases the uricosuric effect of probenecid.
Cefaclor	Probenecid may increase the serum level of cefaclor.
Cefadroxil	Probenecid may increase the serum level of cefadroxil.
Cefamandole	Probenecid may increase the serum level of cefamandole.
Cefazolin	Probenecid may increase the serum level of cefazolin.
Cefepime	Probenecid may increase the serum level of cefepime.
Cefixime	Probenecid may increase the serum level of cefixime.
Cefmetazole	Probenecid may increase the serum level of cefmatzole.
Cefonicid	Probenecid may increase the serum level of cefonicib.
Cefotaxime	Probenecid may increase the serum level of cefotaxime.
Cefotetan	Probenecid may increase the serum level of cefotetan.
Cefoxitin	Probenecid may increase the serum level of cefoxitin.
Cefprozil	Probenecid may increase the serum level of cefprozil.
Cefradine	Probenecid may increase the serum level of cefradine.
Ceftizoxime	Probenecid may increase the serum level of ceftizoxime.
Cefuroxime	Probenecid may increase the serum level of cefuroxime.
Cephalexin	Probenecid may increase the serum level of cephalexin.
Cephaloglycin	Probenecid may increase the serum level of cephaloglycin.
Cephalothin Group	Probenecid may increase the serum level of cephalothin.
Diflunisal	Probenecid increases toxicity of diflunisal
Ganciclovir	Probenecid increases the effect and toxicity of ganciclovir/valganciclovir
Glycerol Phenylbutyrate	Probenecid may inhibit the renal excretion of metabolites of glycerol phenylbutyrate including PAGN and PAA.
Indomethacin	Probenecid increases the effect/toxicity of indomethacin
Ketorolac	Probenecid increases toxicity of ketorolac
Loracarbef	Probenecid may increase the serum level of loracarbef.
Magnesium salicylate	The salicylate, magnesium salicylate, decreases the uricosuric effect of probenecid.
Methotrexate	Probenecid increases the effect and toxicity of methotrexate
Moxalactam Derivative	Probenecid may increase the serum level of the moxalactam derivative.
Pralatrexate	Decreases renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects.
Salicylate-sodium	The salicylate, salicylate-sodium, decreases the uricosuric effect of probenecid.
Salsalate	The salicylate, salsalate, decreases the uricosuric effect of probenecid.
Silodosin	Strong UGT2B7 inhibitors may increase levels of silodosin. Monitor concomitant therapy closely.
Tapentadol	Increases the AUC of tapentadol by 57%. These changes are not considered clinically relevant and no change in dose is required.
Trisalicylate-choline	The salicylate, trisalicylate-choline, decreases the uricosuric effect of probenecid.
Valganciclovir	Probenecid may decrease excretion of Valganciclovir. Monitor for increased serum concentration and toxicity of Valganciclovir.
Zidovudine	Rash, malaise, myalgia

Food Interactions

Take with food to reduce irritation.
Increase liquid intake, avoid alcohol.

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Pharmacological action	yes
Actions	inhibitor
References	Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol. 2001 May 11;419(2-3):113-20. - Pubmed Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Hashimoto T, Narikawa S, Huang XL, Minematsu T, Usui T, Kamimura H, Endou H: Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. Drug Metab Dispos. 2004 Oct;32(10):1096-102. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.7879
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Pharmacological action	yes
Actions	inhibitor
References	Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, Kobayashi Y, Yamamoto T, Sekine T, Cha SH, Niwa T, Endou H: Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802. - Pubmed Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A, Cha SH, Sekine T, Sakthisekaran D, Endou H: Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Hashimoto T, Narikawa S, Huang XL, Minematsu T, Usui T, Kamimura H, Endou H: Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. Drug Metab Dispos. 2004 Oct;32(10):1096-102. - Pubmed
DTHybrid score	0.5042
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Pharmacological action	yes
Actions	inhibitor
References	Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol. 2001 May 11;419(2-3):113-20. - Pubmed Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Sweet DH, Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB: Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am J Physiol Renal Physiol. 2003 Apr;284(4):F763-9. Epub 2002 Dec 17. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.715
Pannexin-1
Name	Pannexin-1
Gene Name	PANX1
Pharmacological action	unknown
Actions	antagonist
References	Silverman W, Locovei S, Dahl G: Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7. Epub 2008 Jul 2. - Pubmed Ransford GA, Fregien N, Qiu F, Dahl G, Conner GE, Salathe M: Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol. 2009 Nov;41(5):525-34. Epub 2009 Feb 12. - Pubmed Ma W, Hui H, Pelegrin P, Surprenant A: Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther. 2009 Feb;328(2):409-18. Epub 2008 Nov 20. - Pubmed Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G: The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5. - Pubmed Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, Dermietzel R: The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J. 2009 Nov;276(21):6258-70. Epub 2009 Sep 24. - Pubmed
DTHybrid score	0.159

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7469
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5814
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.57
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8987

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score	0.4039
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score	0.463
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. - Pubmed Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, Brouwer KL: Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver. J Pharmacol Exp Ther. 2003 Feb;304(2):801-9. - Pubmed
DTHybrid score	0.371
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG: The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002 Mar;13(3):595-603. - Pubmed Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. - Pubmed Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. - Pubmed
DTHybrid score	0.5115
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	inhibitor
References	Jedlitschky G, Burchell B, Keppler D: The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74. - Pubmed
DTHybrid score	0.2979
Monocarboxylate transporter 2
Name	Monocarboxylate transporter 2
Gene Name	SLC16A7
Actions	inhibitor
References	Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score	0.4675
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score	0.4191
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions	inhibitor
References	Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10;277(19):16860-7. Epub 2002 Mar 5. - Pubmed
DTHybrid score	0.2669
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol. 2004 Dec;143(7):856-64. Epub 2004 Oct 25. - Pubmed Minderman H, Brooks TA, O'Loughlin KL, Ojima I, Bernacki RJ, Baer MR: Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023. Cancer Chemother Pharmacol. 2004 May;53(5):363-9. Epub 2004 Jan 27. - Pubmed
DTHybrid score	0.8343
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003 Oct 10;310(1):222-7. - Pubmed Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10;277(19):16860-7. Epub 2002 Mar 5. - Pubmed Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Biochem Biophys Res Commun. 1999 May 19;258(3):513-8. - Pubmed Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. - Pubmed Hooijberg JH, Broxterman HJ, Kool M, Assaraf YG, Peters GJ, Noordhuis P, Scheper RJ, Borst P, Pinedo HM, Jansen G: Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 1999 Jun 1;59(11):2532-5. - Pubmed Legrand O, Simonin G, Beauchamp-Nicoud A, Zittoun R, Marie JP: Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia. Blood. 1999 Aug 1;94(3):1046-56. - Pubmed Legrand O, Simonin G, Perrot JY, Zittoun R, Marie JP: Both Pgp and MRP1 activities using calcein-AM contribute to drug resistance in AML. Adv Exp Med Biol. 1999;457:161-75. - Pubmed Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed Issandou M, Grand-Perret T: Multidrug resistance P-glycoprotein is not involved in cholesterol esterification. Biochem Biophys Res Commun. 2000 Dec 20;279(2):369-77. - Pubmed
DTHybrid score	0.4973
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology. 1994 Aug;20(2):411-6. - Pubmed
DTHybrid score	0.5395
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	inhibitor
References	Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score	0.5579
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	inhibitor
References	Hagenbuch B, Stieger B, Foguet M, Lubbert H, Meier PJ: Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33. - Pubmed
DTHybrid score	0.3371
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. - Pubmed Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol. 2001 May 11;419(2-3):113-20. - Pubmed Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H: Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int. 2003 Jan;63(1):143-55. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. - Pubmed Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. - Pubmed Tsuda M, Sekine T, Takeda M, Cha SH, Kanai Y, Kimura M, Endou H: Transport of ochratoxin A by renal multispecific organic anion transporter 1. J Pharmacol Exp Ther. 1999 Jun;289(3):1301-5. - Pubmed Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, Endou H: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int. 1999 Dec;56(6):2128-36. - Pubmed Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed Uwai Y, Iwamoto K: Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9. - Pubmed
DTHybrid score	0.7879
Solute carrier family 22 member 10
Name	Solute carrier family 22 member 10
Gene Name	SLC22A10
Actions	inhibitor
References	Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol. 2004 Aug;287(2):F236-44. Epub 2004 Apr 6. - Pubmed
DTHybrid score	0.2254
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol. 2001 May 11;419(2-3):113-20. - Pubmed Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. - Pubmed Uwai Y, Iwamoto K: Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9. - Pubmed Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC: Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. Epub 2010 Jun 2. - Pubmed
DTHybrid score	0.715
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003 Oct 10;310(1):222-7. - Pubmed Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10;277(19):16860-7. Epub 2002 Mar 5. - Pubmed Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. - Pubmed Horikawa M, Kato Y, Tyson CA, Sugiyama Y: The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet. 2002;17(1):23-33. - Pubmed Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, Brouwer KL: Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver. J Pharmacol Exp Ther. 2003 Feb;304(2):801-9. - Pubmed Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed Chen C, Scott D, Hanson E, Franco J, Berryman E, Volberg M, Liu X: Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats. Pharm Res. 2003 Jan;20(1):31-7. - Pubmed
DTHybrid score	0.5629
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions	inhibitor
References	Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. - Pubmed
DTHybrid score	0.2739
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, Kobayashi Y, Yamamoto T, Sekine T, Cha SH, Niwa T, Endou H: Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802. - Pubmed Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A, Cha SH, Sekine T, Sakthisekaran D, Endou H: Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
DTHybrid score	0.5042
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	inhibitor
References	Tohyama K, Kusuhara H, Sugiyama Y: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91. Epub 2004 May 27. - Pubmed
DTHybrid score	0.2833
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, Kobayashi Y, Yamamoto T, Sekine T, Cha SH, Niwa T, Endou H: Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802. - Pubmed Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
DTHybrid score	0.4763
Solute carrier family 22 member 12
Name	Solute carrier family 22 member 12
Gene Name	Not Available
Actions	inhibitor
References	Shin HJ, Takeda M, Enomoto A, Fujimura M, Miyazaki H, Anzai N, Endou H: Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Nephrology (Carlton). 2011 Feb;16(2):156-62. doi: 10.1111/j.1440-1797.2010.01368.x. - Pubmed
DTHybrid score	Not Available
Solute carrier family 2, facilitated glucose transporter member 9
Name	Solute carrier family 2, facilitated glucose transporter member 9
Gene Name	Not Available
Actions	inhibitor
References	http://www.pharmgkb.org/pathway/PA165980774 -
DTHybrid score	Not Available

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions
References	Not Available
DTHybrid score	0.4039
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.463
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions
References	Not Available
DTHybrid score	0.371
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.5115
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions
References	Not Available
DTHybrid score	0.2979
Monocarboxylate transporter 2
Name	Monocarboxylate transporter 2
Gene Name	SLC16A7
Actions
References	Not Available
DTHybrid score	0.4675
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions
References	Not Available
DTHybrid score	0.4191
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions
References	Not Available
DTHybrid score	0.2669
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.8343
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.4973
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.5395
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions
References	Not Available
DTHybrid score	0.5579
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions
References	Not Available
DTHybrid score	0.3371
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.7879
Solute carrier family 22 member 10
Name	Solute carrier family 22 member 10
Gene Name	SLC22A10
Actions
References	Not Available
DTHybrid score	0.2254
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.715
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.5629
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions
References	Not Available
DTHybrid score	0.2739
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.5042
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions
References	Not Available
DTHybrid score	0.2833
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.4763
Solute carrier family 22 member 12
Name	Solute carrier family 22 member 12
Gene Name	Not Available
Actions
References	Not Available
DTHybrid score	Not Available
Solute carrier family 2, facilitated glucose transporter member 9
Name	Solute carrier family 2, facilitated glucose transporter member 9
Gene Name	Not Available
Actions
References	Not Available
DTHybrid score	Not Available

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.4215
4200	Cytochrome P450 1A2	CYP1A2	0.3866
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.3698
4118	Cytochrome P450 3A5	CYP3A5	0.3607
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.3329
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.2789
20	Prostaglandin G/H synthase 1	PTGS1	0.257
6107	Cytochrome P450 3A7	CYP3A7	0.2569
500	Monocarboxylate transporter 4	SLC16A3	0.2554
6030	Cytochrome P450 2B6	CYP2B6	0.2532
776	Bile salt export pump	ABCB11	0.246
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.2356
290	Prostaglandin G/H synthase 2	PTGS2	0.2299
6013	Cytochrome P450 2E1	CYP2E1	0.2159
6024	Cytochrome P450 1A1	CYP1A1	0.1678
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.1596
6147	Solute carrier family 22 member 3	SLC22A3	0.1532
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.1498
5718	Cytochrome P450 2A6	CYP2A6	0.1457
833	Organic cation/carnitine transporter 1	SLC22A4	0.1453
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1451
6148	Multidrug resistance-associated protein 7	ABCC10	0.1355
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.1344
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.127
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1269
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1236
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.1212
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.1116
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1073
817	DNA topoisomerase 2-alpha	TOP2A	0.1027
6106	Cytochrome P450 2C18	CYP2C18	0.1015
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.1
6167	Organic solute transporter subunit beta	OSTB	0.0993
6166	Organic solute transporter subunit alpha	OSTA	0.0992
136	Estrogen receptor	ESR1	0.0986
1898	Cytochrome P450 1B1	CYP1B1	0.0927
2929	(S)-2-haloacid dehalogenase	dhlB	0.0787
2995	(S)-2-haloacid dehalogenase	Not Available	0.0787
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0736
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0734
492	Histamine H1 receptor	HRH1	0.0729
3811	Cytochrome P450 19A1	CYP19A1	0.07
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0685
3947	Xanthine dehydrogenase/oxidase	XDH	0.0642
24	Thymidylate synthase	TMP1	0.0633
359	Thymidylate synthase	TYMS	0.0633
2626	Thymidylate synthase	thyA	0.0633
2729	Thymidylate synthase	thyA	0.0633
5352	Thymidylate synthase	THYA	0.0633
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.06
4604	Liver carboxylesterase 1	CES1	0.0592
404	DNA gyrase subunit A	gyrA	0.0591
6224	DNA gyrase subunit A	gyrA	0.0591
6085	Fatty acid-binding protein, intestinal	FABP2	0.059
293	Gamma-glutamyl hydrolase	GGH	0.0588
3685	Catabolite gene activator	crp	0.0582
4655	Adenylate cyclase	cyaC	0.0581
4759	Adenylate cyclase	cyaB2	0.0581
731	HIV-1 protease	HIV-1 protease	0.0581
3917	Methylenetetrahydrofolate reductase	MTHFR	0.058
758	Thyroid hormone receptor alpha	THRA	0.0571
824	Sodium-dependent serotonin transporter	SLC6A4	0.0569
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0568
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0568
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0568
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0568
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0565
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0565
556	Alpha-1A adrenergic receptor	ADRA1A	0.0547
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0547
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0546
1650	Heme carrier protein 1	SLC46A1	0.054
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0538
5626	Nucleoside diphosphate kinase B	NME2	0.0534
3587	Gastrotropin	FABP6	0.0532
477	DNA topoisomerase 4 subunit A	parC	0.0523
886	DNA topoisomerase 4 subunit A	parC	0.0523
6226	DNA topoisomerase 4 subunit A	parC	0.0523
831	D(2) dopamine receptor	DRD2	0.052
338	DNA polymerase	UL30	0.0519
379	DNA polymerase	UL54	0.0519
697	DNA polymerase	ORF28	0.0519
2482	DNA polymerase	43	0.0519
4104	DNA polymerase	BALF5	0.0519
6151	Monocarboxylate transporter 10	SLC16A10	0.0519
6020	Aldehyde oxidase	AOX1	0.0515
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0512
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0512
3179	2-isopropylmalate synthase	leuA	0.0512
373	Transthyretin	TTR	0.0507
33	Cystine/glutamate transporter	SLC7A11	0.0507
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0506
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0506
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0499
4760	Mll3241 protein	mll3241	0.0498
766	Beta-2 adrenergic receptor	ADRB2	0.0498
346	Thyroid hormone receptor beta-1	THRB	0.0495
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0494
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0493
594	Thyroxine-binding globulin	SERPINA7	0.0485
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0476
22	30S ribosomal protein S4	rpsD	0.047
6714	30S ribosomal protein S4	rpsD	0.047
3923	Cholinesterase	BCHE	0.0469
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0466
140	30S ribosomal protein S9	rpsI	0.0466
6719	30S ribosomal protein S9	rpsI	0.0466
6725	30S ribosomal protein S9	rpsI	0.0466
633	Penicillin-binding proteins 1A/1B	pbpA	0.0464
871	Glucocorticoid receptor	NR3C1	0.0461
904	Glutathione S-transferase P	GSTP1	0.0457
468	Cytochrome P450 4A11	CYP4A11	0.0454
5650	NimA-related protein	DR_0842	0.045
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0446
645	Penicillin-binding protein 1A	mrcA	0.0446
5805	Penicillin-binding protein 1A	ponA	0.0446
6185	Penicillin-binding protein 1A	mrcA	0.0446
6799	Penicillin-binding protein 1A	pbpA	0.0446
723	Cytosolic phospholipase A2	PLA2G4A	0.0445
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0443
4132	Chloride channel protein ClC-Ka	CLCNKA	0.044
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0432
5294	Nucleoside diphosphate kinase A	NME1	0.0429
124	Histamine H2 receptor	HRH2	0.0426
193	Beta-1 adrenergic receptor	ADRB1	0.0425
275	Arachidonate 5-lipoxygenase	ALOX5	0.0425
3810	Catechol O-methyltransferase	COMT	0.0421
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.042
756	Sex hormone-binding globulin	SHBG	0.0419
558	Solute carrier family 12 member 1	SLC12A1	0.0419
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0415
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0412
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0412
3334	Deacetoxycephalosporin C synthetase	cefE	0.0408
632	Alpha-1B adrenergic receptor	ADRA1B	0.0405
6031	Cytochrome P450 3A43	CYP3A43	0.0405
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0405
23	D(1A) dopamine receptor	DRD1	0.0399
908	Glutathione S-transferase theta-1	GSTT1	0.0395
146	Androgen receptor	AR	0.0384
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0383
6043	Putative G-protein coupled receptor 44	GPR44	0.0383
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0382
318	Alpha-2A adrenergic receptor	ADRA2A	0.0381
70	Type-1 angiotensin II receptor	AGTR1	0.0381
543	Penicillin-binding protein 1B	mrcB	0.0374
6186	Penicillin-binding protein 1B	ponB	0.0374
6822	Penicillin-binding protein 1b	pbp1b	0.0374
6844	Penicillin-binding protein 1b	pbp1b	0.0374
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0373
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0371
891	Dihydropteroate synthase	folP	0.037
5359	Dihydropteroate synthase	folP	0.037
7175	Dihydropteroate synthase	sulI	0.037
199	Monocarboxylate transporter 8	SLC16A2	0.037
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0367
6500	Phospholipase A2	PLA2G1B	0.0366
380	Cytochrome P450 17A1	CYP17A1	0.0364
161	Tubulin beta chain	TUBB	0.0364
312	Tubulin beta chain	TUB2	0.0364
3941	Amine oxidase [flavin-containing] A	MAOA	0.0362
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0362
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0359
718	Folate receptor gamma	FOLR3	0.0357
299	Folate receptor beta	FOLR2	0.0357
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0357
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0357
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0356
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0355
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0354
1757	Myeloperoxidase	MPO	0.0345
6042	Prostaglandin reductase 2	PTGR2	0.0344
1	Peptidoglycan synthetase ftsI	ftsI	0.0337
4155	Peptidoglycan synthetase ftsI	ftsI	0.0337
614	Progesterone receptor	PGR	0.0325
713	Sodium-dependent dopamine transporter	SLC6A3	0.0325
5818	Folate receptor alpha	FOLR1	0.0318
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0316
1313	Lactoylglutathione lyase	GLO1	0.0314
260	Cytochrome P450 51	ERG11	0.0313
761	Cytochrome P450 51	ERG11	0.0313
3163	Cytochrome P450 51	cyp51	0.0313
629	Alpha-2B adrenergic receptor	ADRA2B	0.0312
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0309
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0308
869	Estrogen receptor beta	ESR2	0.0306
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0305
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0303
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0303
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0303
789	Alpha-1D adrenergic receptor	ADRA1D	0.0301
737	Mineralocorticoid receptor	NR3C2	0.0301
4773	Deoxycytidine kinase	DCK	0.03
4120	NADPH--cytochrome P450 reductase	POR	0.0299
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0297
378	Alpha-2C adrenergic receptor	ADRA2C	0.0296
244	Angiotensin-converting enzyme	ACE	0.0295
847	Mu-type opioid receptor	OPRM1	0.0284
474	Acetylcholinesterase	ACHE	0.0283
1405	Thiopurine S-methyltransferase	TPMT	0.0281
6033	High affinity interleukin-8 receptor A	CXCR1	0.0281
357	Carbonic anhydrase 2	CA2	0.028
4217	Telomerase reverse transcriptase	TERT	0.0275
4192	DNA topoisomerase 2-beta	TOP2B	0.0275
3939	Amine oxidase [flavin-containing] B	MAOB	0.0275
672	Prostaglandin F2-alpha receptor	PTGFR	0.0273
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0271
5353	Glutamate decarboxylase alpha	gadA	0.027
365	Dihydrofolate reductase	DHFR	0.0266
2381	Dihydrofolate reductase	DFR1	0.0266
2833	Dihydrofolate reductase	Not Available	0.0266
2931	Dihydrofolate reductase	folA	0.0266
3544	Dihydrofolate reductase	folA	0.0266
3682	Dihydrofolate reductase	folA	0.0266
6642	Dihydrofolate reductase	folA	0.0266
6756	Dihydrofolate reductase	dfrA	0.0266
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0263
467	Delta-type opioid receptor	OPRD1	0.0262
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0262
3639	Thymidine phosphorylase	deoA	0.0262
3936	Thymidine phosphorylase	TYMP	0.0262
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0261
696	Kappa-type opioid receptor	OPRK1	0.0259
2320	Thymidine kinase, cytosolic	TK1	0.0259
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0258
183	Vascular endothelial growth factor A	VEGFA	0.0258
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0256
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0254
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0254
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.025
592	Carbonic anhydrase 4	CA4	0.0249
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0248
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0248
438	Taste receptor type 1 member 2	TAS1R2	0.0248
6010	Thiamine transporter 1	SLC19A2	0.0248
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0245
6171	Solute carrier family 28 member 3	SLC28A3	0.0245
465	Calmodulin	CALM1	0.0245
6837	Serine/threonine-protein kinase 17B	STK17B	0.0244
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0244
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0243
6146	High affinity copper uptake protein 1	SLC31A1	0.0243
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0242
1629	Transcription factor AP-1	JUN	0.024
1867	Major prion protein	PRNP	0.024
53	Solute carrier family 12 member 5	SLC12A5	0.0239
663	Solute carrier family 12 member 4	SLC12A4	0.0239
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0237
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0237
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0237
952	Dipeptidyl peptidase 4	DPP4	0.0237
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0236
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0235
844	Epidermal growth factor receptor	EGFR	0.0234
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0234
896	Glutathione S-transferase Mu 1	GSTM1	0.0234
122	P2Y purinoceptor 12	P2RY12	0.0234
527	Prostacyclin receptor	PTGIR	0.0234
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0233
7	Nitric oxide synthase, inducible	NOS2	0.0231
295	Carbonic anhydrase 1	CA1	0.0231
273	Apoptosis regulator Bcl-2	BCL2	0.0227
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0227
6165	Copper-transporting ATPase 1	ATP7A	0.0227
6163	Copper-transporting ATPase 2	ATP7B	0.0227
6210	Tubulin delta chain	TUBD1	0.0226
6212	Tubulin gamma-1 chain	TUBG1	0.0226
6211	Tubulin epsilon chain	TUBE1	0.0226
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0226
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0224
310	Solute carrier family 12 member 2	SLC12A2	0.0223
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
29	Tubulin beta-1 chain	TUBB1	0.0222
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0221
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.022
504	Mast/stem cell growth factor receptor	KIT	0.0219
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0219
332	Beta-lactamase	blaZ	0.0219
2478	Beta-lactamase	ampC	0.0219
2613	Beta-lactamase	ampC	0.0219
2635	Beta-lactamase	ampC	0.0219
2700	Beta-lactamase	penP	0.0219
5445	Beta-lactamase	blaB	0.0219
6019	Beta-lactamase	SHV-7	0.0219
6701	Beta-lactamase	cphA	0.0219
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0217
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0215
6014	Cytochrome P450 2A13	CYP2A13	0.0214
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0213
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0213
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0208
4226	Uridine phosphorylase 2	UPP2	0.0207
6207	30S ribosomal protein S14	rpsN	0.0207
6209	30S ribosomal protein S19	rpsS	0.0207
6712	30S ribosomal protein S19	rpsS	0.0207
6726	30S ribosomal protein S19	rpsS	0.0207
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0207
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0205
2449	Tubulin alpha-3 chain	TUBA1A	0.0204
2599	Tyrosine-protein kinase HCK	HCK	0.0203
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0203
887	DNA gyrase subunit B	gyrB	0.0201
4150	DNA gyrase subunit B	gyrB	0.0201
6225	DNA gyrase subunit B	gyrB	0.0201
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.02
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0199
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0198
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0197
2016	Dipeptidase 1	DPEP1	0.0197
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0196
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0196
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0194
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0193
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0192
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0192
6182	Cytochrome P450 2J2	CYP2J2	0.019
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0188
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0187
4225	Uridine phosphorylase 1	UPP1	0.0186
3957	Adenosine deaminase	ADA	0.0185
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0181
131	Synaptic vesicular amine transporter	SLC18A2	0.018
638	D(3) dopamine receptor	DRD3	0.018
397	Monocarboxylate transporter 3	SLC16A8	0.0178
26	Vascular endothelial growth factor receptor 3	FLT4	0.0178
413	Amidophosphoribosyltransferase	PPAT	0.0177
2515	Amidophosphoribosyltransferase	purF	0.0177
3714	Amidophosphoribosyltransferase	purF	0.0177
195	Monocarboxylate transporter 7	SLC16A6	0.0177
429	Monocarboxylate transporter 6	SLC16A5	0.0177
218	Monocarboxylate transporter 5	SLC16A4	0.0177
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0177
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0177
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0177
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0176
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0176
4237	50S ribosomal protein L22	rplV	0.0176
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0176
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0175
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0172
407	Vascular endothelial growth factor receptor 2	KDR	0.0171
4238	50S ribosomal protein L4	rplD	0.0171
5578	50S ribosomal protein L4	rplD	0.0171
6173	50S ribosomal protein L4	rplD	0.0171
6219	50S ribosomal protein L4	rplD	0.0171
4203	Histamine N-methyltransferase	HNMT	0.017
6220	Aryl hydrocarbon receptor	AHR	0.017
32	Vascular endothelial growth factor receptor 1	FLT1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0169
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0168
130	Prostacyclin synthase	PTGIS	0.0168
2249	Aspartate aminotransferase	aspC	0.0167
2671	Aspartate aminotransferase	aspC	0.0167
5490	Aspartate aminotransferase	Not Available	0.0167
1198	Serum paraoxonase/arylesterase 1	PON1	0.0167
6223	Penicillin-binding protein 1C	pbpC	0.0167
2472	Voltage-gated potassium channel	kcsA	0.0164
6366	Voltage-gated potassium channel	kcsA	0.0164
702	UMP-CMP kinase	CMPK1	0.0164
52	Pyruvate kinase isozymes R/L	PKLR	0.0164
4122	Histone deacetylase 2	HDAC2	0.0164
2539	Tubulin alpha-1 chain	TUBA4A	0.0163
6168	Solute carrier family 22 member 16	SLC22A16	0.0161
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0159
860	Nicotinamide N-methyltransferase	NNMT	0.0157
928	Nicotinic acid receptor 2	GPR109B	0.0157
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0157
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0157
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0157
699	Nicotinic acid receptor 1	GPR109A	0.0157
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0156
284	DNA-directed RNA polymerase beta chain	rpoB	0.0156
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0156
2021	Thrombomodulin	THBD	0.0155
2391	Ferrochelatase	hemH	0.0155
6502	Ferrochelatase	DKFZp686P18130	0.0155
1591	Ferrochelatase, mitochondrial	FECH	0.0155
6126	Carbonic anhydrase 7	CA7	0.0155
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0154
65	Matrix metalloproteinase-9	Not Available	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
1517	Beta-3 adrenergic receptor	ADRB3	0.0154
1852	Microtubule-associated protein 2	MAP2	0.0153
3932	Glutathione S-transferase A2	GSTA2	0.0153
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0153
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0153
624	Guanidinoacetate N-methyltransferase	GAMT	0.0151
818	50S ribosomal protein L10	rplJ	0.0151
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.015
3426	Glutamine synthetase	glnA	0.015
3987	Glutamine synthetase	GLUL	0.015
771	Pyruvate carboxylase, mitochondrial	PC	0.0149
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0148
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0148
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0148
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0148
811	Translocator protein	TSPO	0.0147
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0145
563	Thyroid peroxidase	TPO	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
3809	Estrogen-related receptor gamma	ESRRG	0.0144
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0144
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0144
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0144
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0144
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0142
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0141
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0141
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.014
867	Penicillin-binding protein 3	pbpC	0.014
6119	Penicillin-binding protein 3	pbp3	0.014
7154	Penicillin-binding protein 3	pbp3	0.014
7157	Penicillin-binding protein 3	LMHCC_2184	0.014
7162	Penicillin-binding protein 3	pbpB	0.014
7172	Penicillin-binding protein 3	pbp3	0.014
5923	Microtubule-associated protein tau	MAPT	0.0139
5924	Microtubule-associated protein 4	MAP4	0.0139
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0139
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0139
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0138
777	Tumor necrosis factor	TNF	0.0138
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0138
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0138
432	D(4) dopamine receptor	DRD4	0.0138
6102	Arylamine N-acetyltransferase 2	NAT2	0.0137
1654	Interleukin-1 beta	IL1B	0.0137
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0137
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0137
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0136
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0136
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0136
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0136
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0136
6501	Fatty acid-binding protein, liver	FABP1	0.0135
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0135
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0134
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0134
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0134
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0134
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0134
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0134
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0133
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0133
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0133
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0133
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0133
6559	Cytochrome c oxidase subunit 2	ctaC	0.0133
6669	Cytochrome c oxidase subunit 2	ctaC	0.0133
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0133
6558	Cytochrome c oxidase subunit 1	ctaD	0.0133
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0132
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0131
3760	Penicillin-binding protein 5 precursor	dacA	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
232	Corticosteroid-binding globulin	SERPINA6	0.0131
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0131
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0131
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.013
976	Platelet glycoprotein IX	GP9	0.013
3307	Acriflavine resistance protein B	acrB	0.013
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
322	Vasopressin V2 receptor	AVPR2	0.0128
1178	Adenosine A2a receptor	ADORA2A	0.0128
5126	Arginase	rocF	0.0127
819	Penicillin-binding protein 4	dacB	0.0125
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0125
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0125
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0125
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0125
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0125
165	FL cytokine receptor	FLT3	0.0124
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0124
2540	Choloylglycine hydrolase	cbh	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0122
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0121
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0121
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0121
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0121
16	Adenosine A1 receptor	ADORA1	0.012
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.012
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.012
1050	Bile salt sulfotransferase	SULT2A1	0.012
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
1648	Elastin	ELN	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
164	Histamine H4 receptor	HRH4	0.0118
2808	Chloramphenicol acetyltransferase 3	cat3	0.0118
1039	Histone deacetylase 9	HDAC9	0.0117
828	Phenylalanine-4-hydroxylase	PAH	0.0116
3109	Phenylalanine-4-hydroxylase	phhA	0.0116
2211	Fatty acid-binding protein, heart	FABP3	0.0114
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0114
1507	Cytochrome c	CYCS	0.0113
163	D(1B) dopamine receptor	DRD5	0.0113
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0113
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0113
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0113
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0113
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0112
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0111
494	Caspase-1	CASP1	0.0111
4790	Glycosyltransferase GtfA	gtfA	0.011
890	Niemann-Pick C1-like protein 1	NPC1L1	0.011
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0109
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0109
1341	Histamine H3 receptor	HRH3	0.0109
2443	Azurin	azu	0.0108
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0108
1192	Sulfotransferase 1A1	SULT1A1	0.0108
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0108
1792	Tissue-type plasminogen activator	PLAT	0.0107
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0106
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0106
1353	DNA topoisomerase 1	TOP1	0.0105
3552	DNA topoisomerase 1	topA	0.0105
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0105
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0105
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0105
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0105
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0104
751	Potassium channel subfamily K member 6	KCNK6	0.0104
6138	Multidrug resistance protein 3	ABCB4	0.0104
482	Glycine receptor subunit alpha-1	GLRA1	0.0103
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0102
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0102
6432	Transporter	snf	0.0102
5482	Sialidase-2	NEU2	0.0101
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.01
705	Glutamate receptor 1	GRIA1	0.01
461	Glycine receptor subunit alpha-3	GLRA3	0.01
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0099
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
694	Matrix protein 2	M	0.0098
2300	Lysozyme	E	0.0098
3633	Lysozyme	R	0.0098
5597	Lysozyme	17	0.0098
921	Glutamate receptor 2	GRIA2	0.0097
517	Alcohol dehydrogenase 1C	ADH1C	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
1760	Aminopeptidase N	ANPEP	0.0097
6843	Aminopeptidase N	pepN	0.0097
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0097
6067	Penicillin binding protein 2a	mecA	0.0096
5787	Angiopoietin-1 receptor	TEK	0.0096
49	Endothelin B receptor	EDNRB	0.0096
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0095
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0095
172	Potassium channel subfamily K member 1	KCNK1	0.0095
117	Sterol O-acyltransferase 1	SOAT1	0.0095
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
3611	Cytidine deaminase	cdd	0.0095
3707	Cytidine deaminase	cdd	0.0095
4211	Cytidine deaminase	CDA	0.0095
566	Serotransferrin	TF	0.0094
469	Annexin A1	ANXA1	0.0094
1010	Cytochrome P450 51A1	CYP51A1	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
2077	Caspase-3	CASP3	0.0093
1618	High affinity nerve growth factor receptor	NTRK1	0.0093
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
291	Nitric-oxide synthase, endothelial	NOS3	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
6070	Nischarin	NISCH	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
1656	CYP2B protein	CYP2B	0.0088
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0087
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0087
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0087
571	Melatonin receptor type 1A	MTNR1A	0.0087
362	Melatonin receptor type 1B	MTNR1B	0.0087
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0086
3014	Ribonuclease UK114	HRSP12	0.0086
5428	Replication protein	repA	0.0086
3617	Non-heme chloroperoxidase	cpo	0.0086
5426	Non-heme chloroperoxidase	cpo	0.0086
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0086
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0086
3018	HTH-type transcriptional regulator malT	malT	0.0086
459	Retinoic acid receptor RXR-alpha	RXRA	0.0086
427	Substance-P receptor	TACR1	0.0084
1830	5'-nucleotidase	NT5E	0.0084
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0084
153	Dopamine beta-hydroxylase	DBH	0.0084
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0083
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0082
277	Purine nucleoside phosphorylase	PNP	0.0082
2870	Purine nucleoside phosphorylase	punA	0.0082
2945	Purine nucleoside phosphorylase	punA	0.0082
4659	Purine nucleoside phosphorylase	TM_1596	0.0082
4825	Purine nucleoside phosphorylase	TTHA1435	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
716	5-hydroxytryptamine 7 receptor	HTR7	0.0081
125	DNA polymerase beta	POLB	0.0081
88	Retinoic acid receptor RXR-beta	RXRB	0.008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.008
4210	Toll-like receptor 4	TLR4	0.008
1630	Integrin beta-2	ITGB2	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0079
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0079
1770	Phospholipase C	PLCL1	0.0079
2841	Phospholipase C	plc	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1291	cAMP response element-binding protein	CREB1	0.0078
2298	Cytochrome P450-cam	camC	0.0077
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
6131	Carbonic anhydrase 14	CA14	0.0075
1541	Metalloproteinase	mmp20	0.0074
2958	Probable tautomerase ydcE	pptA	0.0074
4034	Glutaredoxin-1	GLRX	0.0074
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0074
1928	Leukotriene C4 synthase	LTC4S	0.0074
4037	Hypothetical protein	GPX1	0.0074
4297	Hypothetical protein	SP_1951	0.0074
4521	Hypothetical protein	BC_2969	0.0074
4540	Hypothetical protein	TM_1070	0.0074
4555	Hypothetical protein	MT1739	0.0074
4569	Hypothetical protein	mshD	0.0074
4578	Hypothetical protein	PA3270	0.0074
4747	Hypothetical protein	PA3967	0.0074
5177	Hypothetical protein	TM_0096	0.0074
5194	Hypothetical protein	PA1204	0.0074
5240	Hypothetical protein	Rv2991	0.0074
5370	Hypothetical protein	TM_1158	0.0074
5710	Hypothetical protein	Tb927.5.1360	0.0074
4029	Microsomal glutathione S-transferase 3	MGST3	0.0074
2573	Cocaine esterase	cocE	0.0074
7263	Cocaine esterase	Not Available	0.0074
4032	Microsomal glutathione S-transferase 1	MGST1	0.0074
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0074
910	Epididymal secretory glutathione peroxidase	GPX5	0.0074
4035	Glutathione S-transferase Mu 5	GSTM5	0.0074
4040	Glutathione peroxidase 7	GPX7	0.0074
4036	Glutathione peroxidase 6	GPX6	0.0074
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0074
903	Glutathione S-transferase A5	GSTA5	0.0074
911	Glutathione peroxidase 3	GPX3	0.0074
906	Glutathione peroxidase 1	GPX1	0.0074
907	Glutathione peroxidase 2	GPX2	0.0074
900	Glutathione S-transferase A4	GSTA4	0.0074
4038	Glutathione peroxidase 4	GPX4	0.0074
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0074
4042	Glutathione transferase omega-2	GSTO2	0.0074
4033	S-formylglutathione hydrolase	ESD	0.0074
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0074
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0074
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0073
76	Nitric-oxide synthase, brain	NOS1	0.0073
1636	Trace amine-associated receptor 1	TAAR1	0.0073
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0073
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0073
634	Squalene monooxygenase	SQLE	0.0073
7196	Squalene monooxygenase	ERG1	0.0073
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0073
4041	Microsomal glutathione S-transferase 2	MGST2	0.0073
3115	Ras-related protein Rab-9	RAB9A	0.0073
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0073
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0072
5682	Ribonuclease pancreatic	RNASE1	0.0072
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
5300	Antigen peptide transporter 1	TAP1	0.0071
1714	Mitogen-activated protein kinase 3	MAPK3	0.0071
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.007
6122	Carbonic anhydrase 3	CA3	0.007
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0067
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0066
36	Insulin receptor	INSR	0.0066
897	Glutathione S-transferase kappa 1	GSTK1	0.0066
898	Glutathione S-transferase A3	GSTA3	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
1196	Complement decay-accelerating factor	CD55	0.0065
909	Maleylacetoacetate isomerase	GSTZ1	0.0065
6044	Serum paraoxonase/lactonase 3	PON3	0.0065
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0065
780	Retinoic acid receptor RXR-gamma	RXRG	0.0064
905	Glutathione transferase omega-1	GSTO1	0.0064
899	Glutathione S-transferase Mu 3	GSTM3	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0063
133	Dihydropterate synthase	sulI	0.0063
3270	Elongation factor G	fusA	0.0062
768	FK506-binding protein 1A	FKBP1A	0.0062
1864	RET proto-oncogene	RET	0.0062
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0061
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0061
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0061
94	5-hydroxytryptamine 4 receptor	HTR4	0.0061
84	Nuclear receptor 0B1	NR0B1	0.006
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.006
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.006
3007	Carbonic anhydrase 12	CA12	0.006
4205	Carbonic anhydrase 9	CA9	0.006
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
572	Integrin alpha-L	ITGAL	0.006
1275	Estrogen sulfotransferase	SULT1E1	0.006
6103	Arylamine N-acetyltransferase 1	NAT1	0.0059
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0059
992	Protein tyrosine kinase 2 beta	PTK2B	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0058
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0058
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0058
2165	Glutathione S-transferase Mu 2	GSTM2	0.0058
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0058
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0058
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0058
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0057
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
707	72 kDa type IV collagenase	MMP2	0.0057
207	Glutathione synthetase	GSS	0.0057
5269	Glutathione synthetase	gshB	0.0057
5934	Cytochrome P450 26A1	CYP26A1	0.0057
788	Creatine kinase M-type	CKM	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
4031	Glutathione S-transferase A1	GSTA1	0.0057
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0057
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0057
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0056
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0056
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0056
3926	Choline transporter-like protein 2	SLC44A2	0.0056
861	Choline kinase alpha	CHKA	0.0056
1686	Choline transporter-like protein 1	SLC44A1	0.0056
769	High-affinity choline transporter 1	SLC5A7	0.0056
3927	Choline transporter-like protein 3	SLC44A3	0.0056
3925	Choline transporter-like protein 4	SLC44A4	0.0056
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0056
2693	Heat-labile enterotoxin B chain	eltB	0.0056
700	Choline dehydrogenase, mitochondrial	CHDH	0.0056
576	Choline O-acetyltransferase	CHAT	0.0056
3922	Phospholipase D2	PLD2	0.0056
3924	Phospholipase D1	PLD1	0.0056
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0056
856	Vitamin D3 receptor	VDR	0.0055
162	Retinoic acid receptor gamma-1	RARG	0.0055
6645	D-amino-acid oxidase	DAO	0.0055
6174	50S ribosomal protein L32	rpmF	0.0055
319	Opioid receptor, sigma 1	OPRS1	0.0055
814	Ryanodine receptor 1	RYR1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
901	Glutathione S-transferase Mu 4	GSTM4	0.0054
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0054
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
823	Fibroblast growth factor receptor 2	FGFR2	0.0053
239	Coagulation factor X	F10	0.0053
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0053
4103	Proteasome subunit beta type 2	PSMB2	0.0052
4102	Proteasome subunit beta type 5	PSMB5	0.0052
4101	Proteasome subunit beta type 1	PSMB1	0.0052
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0052
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
2417	Chloramphenicol acetyltransferase	cat	0.0052
3278	Chloramphenicol acetyltransferase	cat	0.0052
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0052
2810	Dr hemagglutinin structural subunit	draA	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
1992	Vitamin D-binding protein	GC	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.005
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
518	Peroxidase/catalase T	katG	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0049
1123	Eosinophil cationic protein	RNASE3	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0048
551	Carnitine O-acetyltransferase	CRAT	0.0047
714	Glutathione reductase, mitochondrial	GSR	0.0047
6677	Myelin P2 protein	PMP2	0.0047
268	Adenosine A2b receptor	ADORA2B	0.0047
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0047
683	Potassium transporter	GK0582	0.0047
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0046
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0046
54	Prothrombin	F2	0.0045
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
581	Cytochrome P450 2R1	CYP2R1	0.0043
1483	Membrane copper amine oxidase	AOC3	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
408	Riboflavin kinase	RFK	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4311	tRNA	TRDMT1	0.004
4325	tRNA	trmD	0.004
4328	tRNA	trmD	0.004
4161	Furin	FURIN	0.004
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0039
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0039
2408	Tyrosine-protein kinase SYK	SYK	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3830	Calreticulin	CALR	0.0038
3856	Fibroblast growth factor receptor 3	FGFR3	0.0038
740	Argininosuccinate synthase	ASS1	0.0038
865	Argininosuccinate synthase	ASS1	0.0038
2680	Argininosuccinate synthase	argG	0.0038
3194	Argininosuccinate synthase	argG	0.0038
85	Growth hormone receptor	GHR	0.0038
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0037
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0037
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0037
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
6034	Hydroxyindole O-methyltransferase	ASMT	0.0035
6035	Nuclear receptor ROR-beta	RORB	0.0035
997	Protein kinase C beta type	PRKCB	0.0035
6036	Eosinophil peroxidase	EPX	0.0035
3808	Dihydropteroate synthase 2	folP2	0.0035
3601	Dihydropteroate synthase 1	folP1	0.0035
3807	Dihydropteroate synthase 1	folP1	0.0035
2112	Toll-like receptor 9	TLR9	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2207	Rhodopsin	RHO	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6228	Nuclear receptor coactivator 1	NCOA1	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
499	Arginine decarboxylase	ADC	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
174	Sigma 1-type opioid receptor	SIGMAR1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
735	Alanine aminotransferase 1	GPT	0.0031
3904	Alanine aminotransferase 2	GPT2	0.0031
765	Indoleamine 2,3-dioxygenase	IDO1	0.0031
577	Argininosuccinate lyase	ASL	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
936	Ephrin type-A receptor 2	EPHA2	0.003
3937	Fatty-acid amide hydrolase	FAAH	0.0029
654	Flavin reductase	BLVRB	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
2236	Casein kinase II subunit alpha	CSNK2A1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
5798	Mitogen-activated protein kinase 11	MAPK11	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0026
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0026
822	Aldose reductase	AKR1B1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
3913	Glutamic acid decarboxylase	GAD65	0.0025
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6048	Troponin C, skeletal muscle	TNNC2	0.0024
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0023
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
267	Plasminogen activator inhibitor 1	SERPINE1	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6221	Steroid hormone receptor ERR1	ESRRA	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
444	Alcohol dehydrogenase 1B	ADH1B	0.0019
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0018
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0018
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0018
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0018
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0018
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
719	Retinoic acid receptor responder protein 1	RARRES1	0.0017
770	Retinoic acid-induced protein 3	GPRC5A	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
569	Retinal dehydrogenase 2	ALDH1A2	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
611	Retinal dehydrogenase 1	ALDH1A1	0.0014
760	Fibroblast growth factor 1	FGF1	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3221	Cytochrome c4	cc4	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0013
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0013
1912	Excitatory amino acid transporter 1	SLC1A3	0.0013
4019	Excitatory amino acid transporter 4	SLC1A6	0.0013
922	Glutamate receptor 4	GRIA4	0.0013
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0013
4026	Aspartyl aminopeptidase	DNPEP	0.0013
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0013
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0013
4016	Excitatory amino acid transporter 5	SLC1A7	0.0013
1047	Excitatory amino acid transporter 2	SLC1A2	0.0013
927	Metabotropic glutamate receptor 8	GRM8	0.0013
664	Glutamate decarboxylase 2	GAD2	0.0013
3890	Glutamate decarboxylase 2	GAD2	0.0013
4020	Glutamyl aminopeptidase	ENPEP	0.0013
4018	Glutamate receptor delta-2 subunit	GRID2	0.0013
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0013
925	Metabotropic glutamate receptor 4	GRM4	0.0013
926	Metabotropic glutamate receptor 7	GRM7	0.0013
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0013
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0013
4027	Glutamate receptor delta-1 subunit	GRID1	0.0013
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0013
4017	5-oxoprolinase	OPLAH	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
625	Glutamate carboxypeptidase 2	FOLH1	0.0012
292	Activin receptor type-1	ACVR1	0.0012
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0012
1295	Fatty acid synthase	FASN	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6859	Protein S100-A4	S100A4	0.0012
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0012
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0011
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0011
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0011
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0011
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0011
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
916	Metabotropic glutamate receptor 1	GRM1	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
665	Phosphoserine aminotransferase	PSAT1	0.0011
4652	Phosphoserine aminotransferase	serC	0.0011
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0011
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0011
420	Glutamate decarboxylase 1	GAD1	0.0011
3900	Glutamate decarboxylase 1	GAD1	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
923	Glutamate receptor 3	GRIA3	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0011
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
1671	Excitatory amino acid transporter 3	SLC1A1	0.001
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
3877	Growth-inhibiting protein 18	GIG18	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
426	Aspartate aminotransferase, mitochondrial	GOT2	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
763	Tyrosine aminotransferase	TAT	0.001
5493	Tyrosine aminotransferase	Not Available	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4943	Cytochrome c6	petJ	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
5000	HemO	hemO	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4984	Neuroglobin	NGB	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4909	CooA protein	cooA	0.0008
4910	Cytoglobin	CYGB	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4972	P450cin	cinA	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01032 - Probenecid

Targets

Enzymes

Transporters

Carriers

Predictions