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DB01150 - Cefprozil


Identification
Name Cefprozil
Accession Number DB01150 (APRD00461)
Type small molecule
Description Cefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 389.426
Groups approved
Monoisotopic Weight 389.104541423
Pharmacology
Indication For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Mechanism of action Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.
Absorption Oral bioavailability is approximately 95%.
Protein binding 36%
Biotransformation Cefprozil is eliminated primarily by the kidneys
Route of elimination Not Available
Toxicity Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Probenecid Probenecid may increase the serum level of cefprozil.
Food Interactions
  • Take without regard to meals.

Targets


Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name ponA
Pharmacological action yes
Actions inhibitor
References
  • Nagai K, Davies TA, Jacobs MR, Appelbaum PC: Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80. - Pubmed
DTHybrid score 1.5059
Penicillin-binding protein 2x
Name Penicillin-binding protein 2x
Gene Name pbpX
Pharmacological action yes
Actions inhibitor
References
  • Nagai K, Davies TA, Jacobs MR, Appelbaum PC: Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80. - Pubmed
DTHybrid score 1.5058
Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Nagai K, Davies TA, Jacobs MR, Appelbaum PC: Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80. - Pubmed
DTHybrid score 1.2176

Predictions


Id Partner name Gene Name Score
645 Penicillin-binding protein 1A mrcA 1.5059
6185 Penicillin-binding protein 1A mrcA 1.5059
6799 Penicillin-binding protein 1A pbpA 1.5059
3403 Penicillin-binding protein 2X pbpX 1.5058
6121 Penicillin-binding protein 2B penA 1.2176
4252 Penicillin-binding protein 5 dacA 0.0777
633 Penicillin-binding proteins 1A/1B pbpA 0.0502
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0408
332 Beta-lactamase blaZ 0.0389
2478 Beta-lactamase ampC 0.0389
2613 Beta-lactamase ampC 0.0389
2635 Beta-lactamase ampC 0.0389
2700 Beta-lactamase penP 0.0389
5445 Beta-lactamase blaB 0.0389
6019 Beta-lactamase SHV-7 0.0389
6701 Beta-lactamase cphA 0.0389
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0388
1729 Solute carrier family 22 member 6 SLC22A6 0.0311
587 Serum albumin ALB 0.0299
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