DT-Web

DB01140 - Cefadroxil


Identification
Name Cefadroxil
Accession Number DB01140 (APRD00196)
Type small molecule
Description Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 363.388
Groups approved
Monoisotopic Weight 363.088891359
Pharmacology
Indication For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes
Mechanism of action Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.
Absorption Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption.
Protein binding Binding rates of cefadroxil were 28.1% by U.F. method
Biotransformation Not Available
Route of elimination Over 90% of the drug is excreted unchanged in the urine within 24 hours. It crosses the placenta and appears in breast milk.
Toxicity Nausea, vomiting, diarrhoea, allergic rashes may occur
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Probenecid Probenecid may increase the serum level of cefadroxil.
Food Interactions
  • Take without regard to meals.
  • Food may reduce the digestive problems that sometimes occur.

Targets


Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0416
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.097
Penicillin-binding protein 1b
Name Penicillin-binding protein 1b
Gene Name pbp1b
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0803
Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
  • Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE: Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther. 2004 Feb;308(2):462-7. Epub 2003 Nov 4. - Pubmed
  • Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE: Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther. 2004 Feb;308(2):462-7. Epub 2003 Nov 4. - Pubmed
DTHybrid score 0.0151

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate,inhibitor
References
  • Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH: Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7. - Pubmed
  • Wenzel U, Gebert I, Weintraut H, Weber WM, Clauss W, Daniel H: Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J Pharmacol Exp Ther. 1996 May;277(2):831-9. - Pubmed
  • Balimane PV, Tamai I, Guo A, Nakanishi T, Kitada H, Leibach FH, Tsuji A, Sinko PJ: Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. Biochem Biophys Res Commun. 1998 Sep 18;250(2):246-51. - Pubmed
  • Guo A, Hu P, Balimane PV, Leibach FH, Sinko PJ: Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J Pharmacol Exp Ther. 1999 Apr;289(1):448-54. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. - Pubmed
  • Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeda E, Higashida H, Tsuji A: The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J Pharm Pharmacol. 1997 Aug;49(8):796-801. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Wenzel U, Gebert I, Weintraut H, Weber WM, Clauss W, Daniel H: Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J Pharmacol Exp Ther. 1996 May;277(2):831-9. - Pubmed
DTHybrid score 0.7523
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.4021
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.5122
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH: Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
  • Ocheltree, S.M. et al. Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther 308, 462-467 (2004). - Pubmed
DTHybrid score 0.7461
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
DTHybrid score 0.3419

Predictions


Id Partner name Gene Name Score
633 Penicillin-binding proteins 1A/1B pbpA 0.2305
244 Angiotensin-converting enzyme ACE 0.1808
1024 Solute carrier family 22 member 11 SLC22A11 0.1693
587 Serum albumin ALB 0.1281
6143 Solute carrier family 22 member 7 SLC22A7 0.1171
4512 Cytochrome P450 3A4 CYP3A4 0.1116
645 Penicillin-binding protein 1A mrcA 0.097
5805 Penicillin-binding protein 1A ponA 0.097
6185 Penicillin-binding protein 1A mrcA 0.097
1 Peptidoglycan synthetase ftsI ftsI 0.09
4155 Peptidoglycan synthetase ftsI ftsI 0.09
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0878
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0841
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0841
543 Penicillin-binding protein 1B mrcB 0.0803
6186 Penicillin-binding protein 1B ponB 0.0803
6822 Penicillin-binding protein 1b pbp1b 0.0803
1588 Multidrug resistance protein 1 ABCB1 0.0716
833 Organic cation/carnitine transporter 1 SLC22A4 0.0634
4119 Cytochrome P450 2D6 CYP2D6 0.0604
738 Monocarboxylate transporter 1 SLC16A1 0.0602
4200 Cytochrome P450 1A2 CYP1A2 0.0573
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0529
6145 Solute carrier family 22 member 1 SLC22A1 0.0528
4757 Cytochrome P450 2C9 CYP2C9 0.0524
6144 Solute carrier family 22 member 2 SLC22A2 0.0476
20 Prostaglandin G/H synthase 1 PTGS1 0.0474
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0456
6067 Penicillin binding protein 2a mecA 0.0453
6016 Cytochrome P450 2C19 CYP2C19 0.0451
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0418
3760 Penicillin-binding protein 5 precursor dacA 0.0416
867 Penicillin-binding protein 3 pbpC 0.0416
6119 Penicillin-binding protein 3 pbp3 0.0416
7157 Penicillin-binding protein 3 LMHCC_2184 0.0416
7162 Penicillin-binding protein 3 pbpB 0.0416
7172 Penicillin-binding protein 3 pbp3 0.0416
2164 Multidrug resistance-associated protein 4 ABCC4 0.0412
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0397
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0395
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0394
290 Prostaglandin G/H synthase 2 PTGS2 0.0382
3195 Beta-lactamase Toho-1 bla 0.0357
1757 Myeloperoxidase MPO 0.0357
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0356
1385 Angiotensin-converting enzyme 2 ACE2 0.035
115 Penicillin-binding protein 2 mrdA 0.0335
6069 Penicillin-binding protein 2 mrdA 0.0335
6118 Penicillin-binding protein 2 penA 0.0335
6187 Penicillin-binding protein 2 pbpA 0.0335
6686 Penicillin-binding protein 2 pbp2 0.0335
6939 Penicillin-binding protein 2 mrdA 0.0335
7163 Penicillin-binding protein 2 pbpA 0.0335
6147 Solute carrier family 22 member 3 SLC22A3 0.0328
404 DNA gyrase subunit A gyrA 0.0314
6224 DNA gyrase subunit A gyrA 0.0314
862 Multidrug resistance-associated protein 1 ABCC1 0.0312
4924 Cytochrome P450 2C8 CYP2C8 0.0312
338 DNA polymerase UL30 0.0303
379 DNA polymerase UL54 0.0303
697 DNA polymerase ORF28 0.0303
2482 DNA polymerase 43 0.0303
4104 DNA polymerase BALF5 0.0303
819 Penicillin-binding protein 4 dacB 0.0288
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0252
4604 Liver carboxylesterase 1 CES1 0.0251
234 Plasminogen PLG 0.0246
477 DNA topoisomerase 4 subunit A parC 0.0242
886 DNA topoisomerase 4 subunit A parC 0.0242
6226 DNA topoisomerase 4 subunit A parC 0.0242
3426 Glutamine synthetase glnA 0.0237
3987 Glutamine synthetase GLUL 0.0237
3923 Cholinesterase BCHE 0.0234
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
3917 Methylenetetrahydrofolate reductase MTHFR 0.0218
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0216
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0215
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0215
4118 Cytochrome P450 3A5 CYP3A5 0.021
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
776 Bile salt export pump ABCB11 0.0191
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0185
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.018
6024 Cytochrome P450 1A1 CYP1A1 0.0177
817 DNA topoisomerase 2-alpha TOP2A 0.0174
22 30S ribosomal protein S4 rpsD 0.0173
6714 30S ribosomal protein S4 rpsD 0.0173
6106 Cytochrome P450 2C18 CYP2C18 0.0166
140 30S ribosomal protein S9 rpsI 0.0163
6719 30S ribosomal protein S9 rpsI 0.0163
6725 30S ribosomal protein S9 rpsI 0.0163
509 Thymidine kinase TK 0.0161
570 Thymidine kinase TK 0.0161
2559 Thymidine kinase TK 0.0161
3430 Thymidine kinase tdk 0.0161
3518 Thymidine kinase TK 0.0161
5301 Thymidine kinase tdk 0.0161
5771 Thymidine kinase ORF36 0.0161
7009 Thymidine kinase ORF36 0.0161
6136 Multidrug resistance-associated protein 5 ABCC5 0.0155
159 Penicillin-binding protein 2B penA 0.0151
357 Carbonic anhydrase 2 CA2 0.015
6107 Cytochrome P450 3A7 CYP3A7 0.0149
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
4252 Penicillin-binding protein 5 dacA 0.0146
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
592 Carbonic anhydrase 4 CA4 0.0141
332 Beta-lactamase blaZ 0.0138
2478 Beta-lactamase ampC 0.0138
2613 Beta-lactamase ampC 0.0138
2635 Beta-lactamase ampC 0.0138
2700 Beta-lactamase penP 0.0138
5445 Beta-lactamase blaB 0.0138
6019 Beta-lactamase SHV-7 0.0138
6701 Beta-lactamase cphA 0.0138
6141 Sodium/bile acid cotransporter SLC10A1 0.0137
295 Carbonic anhydrase 1 CA1 0.0133
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0132
5718 Cytochrome P450 2A6 CYP2A6 0.0132
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.013
318 Alpha-2A adrenergic receptor ADRA2A 0.0129
5626 Nucleoside diphosphate kinase B NME2 0.0127
124 Histamine H2 receptor HRH2 0.0126
558 Solute carrier family 12 member 1 SLC12A1 0.0125
492 Histamine H1 receptor HRH1 0.0123
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
438 Taste receptor type 1 member 2 TAS1R2 0.0122
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.012
6030 Cytochrome P450 2B6 CYP2B6 0.012
3810 Catechol O-methyltransferase COMT 0.012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0119
1141 Sialidase-1 NEU1 0.0117
64 Neuraminidase NA 0.0117
641 Neuraminidase NA 0.0117
2676 Neuraminidase NA 0.0117
3026 Neuraminidase NA 0.0117
3519 Neuraminidase NA 0.0117
6007 Neuraminidase NA 0.0117
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0111
3686 Acyl-CoA thioesterase I precursor tesA 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
6013 Cytochrome P450 2E1 CYP2E1 0.0103
624 Guanidinoacetate N-methyltransferase GAMT 0.01
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.01
3947 Xanthine dehydrogenase/oxidase XDH 0.0099
887 DNA gyrase subunit B gyrB 0.0099
4150 DNA gyrase subunit B gyrB 0.0099
6225 DNA gyrase subunit B gyrB 0.0099
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0095
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0094
6137 Multidrug resistance-associated protein 6 ABCC6 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0092
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0091
5353 Glutamate decarboxylase alpha gadA 0.0091
5482 Sialidase-2 NEU2 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
65 Matrix metalloproteinase-9 Not Available 0.009
6149 Solute carrier family 22 member 10 SLC22A10 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
6148 Multidrug resistance-associated protein 7 ABCC10 0.0088
6020 Aldehyde oxidase AOX1 0.0087
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0086
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0084
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0084
632 Alpha-1B adrenergic receptor ADRA1B 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
2472 Voltage-gated potassium channel kcsA 0.0083
6366 Voltage-gated potassium channel kcsA 0.0083
6126 Carbonic anhydrase 7 CA7 0.0082
556 Alpha-1A adrenergic receptor ADRA1A 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0079
2320 Thymidine kinase, cytosolic TK1 0.0074
373 Transthyretin TTR 0.0073
707 72 kDa type IV collagenase MMP2 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
6167 Organic solute transporter subunit beta OSTB 0.0073
6166 Organic solute transporter subunit alpha OSTA 0.0073
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0069
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
1867 Major prion protein PRNP 0.0067
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0067
3941 Amine oxidase [flavin-containing] A MAOA 0.0066
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
275 Arachidonate 5-lipoxygenase ALOX5 0.0064
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
5126 Arginase rocF 0.0063
474 Acetylcholinesterase ACHE 0.0063
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0063
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0063
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
6151 Monocarboxylate transporter 10 SLC16A10 0.0062
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0061
1405 Thiopurine S-methyltransferase TPMT 0.0061
130 Prostacyclin synthase PTGIS 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
380 Cytochrome P450 17A1 CYP17A1 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
6207 30S ribosomal protein S14 rpsN 0.0058
6209 30S ribosomal protein S19 rpsS 0.0058
6712 30S ribosomal protein S19 rpsS 0.0058
6726 30S ribosomal protein S19 rpsS 0.0058
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0058
788 Creatine kinase M-type CKM 0.0057
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0057
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0057
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0056
2249 Aspartate aminotransferase aspC 0.0056
2671 Aspartate aminotransferase aspC 0.0056
5490 Aspartate aminotransferase Not Available 0.0056
4760 Mll3241 protein mll3241 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6033 High affinity interleukin-8 receptor A CXCR1 0.0051
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
1198 Serum paraoxonase/arylesterase 1 PON1 0.005
6223 Penicillin-binding protein 1C pbpC 0.005
527 Prostacyclin receptor PTGIR 0.005
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
3811 Cytochrome P450 19A1 CYP19A1 0.0049
6168 Solute carrier family 22 member 16 SLC22A16 0.0049
672 Prostaglandin F2-alpha receptor PTGFR 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
146 Androgen receptor AR 0.0048
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0048
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0048
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0048
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0048
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0048
551 Carnitine O-acetyltransferase CRAT 0.0047
24 Thymidylate synthase TMP1 0.0047
359 Thymidylate synthase TYMS 0.0047
2626 Thymidylate synthase thyA 0.0047
2729 Thymidylate synthase thyA 0.0047
5352 Thymidylate synthase THYA 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0045
1654 Interleukin-1 beta IL1B 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0045
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
756 Sex hormone-binding globulin SHBG 0.0042
53 Solute carrier family 12 member 5 SLC12A5 0.0042
663 Solute carrier family 12 member 4 SLC12A4 0.0042
408 Riboflavin kinase RFK 0.0041
6014 Cytochrome P450 2A13 CYP2A13 0.004
1039 Histone deacetylase 9 HDAC9 0.004
6218 Pannexin-1 PANX1 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
310 Solute carrier family 12 member 2 SLC12A2 0.0039
6043 Putative G-protein coupled receptor 44 GPR44 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
163 D(1B) dopamine receptor DRD5 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
494 Caspase-1 CASP1 0.0037
2300 Lysozyme E 0.0037
3633 Lysozyme R 0.0037
5597 Lysozyme 17 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
5682 Ribonuclease pancreatic RNASE1 0.0036
183 Vascular endothelial growth factor A VEGFA 0.0036
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0036
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0036
193 Beta-1 adrenergic receptor ADRB1 0.0036
293 Gamma-glutamyl hydrolase GGH 0.0036
432 D(4) dopamine receptor DRD4 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
1507 Cytochrome c CYCS 0.0035
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0035
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0035
638 D(3) dopamine receptor DRD3 0.0034
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0034
1341 Histamine H3 receptor HRH3 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
4217 Telomerase reverse transcriptase TERT 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
499 Arginine decarboxylase ADC 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
164 Histamine H4 receptor HRH4 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
1650 Heme carrier protein 1 SLC46A1 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
2077 Caspase-3 CASP3 0.0031
23 D(1A) dopamine receptor DRD1 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
654 Flavin reductase BLVRB 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
831 D(2) dopamine receptor DRD2 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
3587 Gastrotropin FABP6 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
2021 Thrombomodulin THBD 0.0027
1025 Aquaporin-1 AQP1 0.0027
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
4773 Deoxycytidine kinase DCK 0.0026
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0026
976 Platelet glycoprotein IX GP9 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
136 Estrogen receptor ESR1 0.0025
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0024
6031 Cytochrome P450 3A43 CYP3A43 0.0024
1898 Cytochrome P450 1B1 CYP1B1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
5818 Folate receptor alpha FOLR1 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
6042 Prostaglandin reductase 2 PTGR2 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
7 Nitric oxide synthase, inducible NOS2 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
1792 Tissue-type plasminogen activator PLAT 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
1517 Beta-3 adrenergic receptor ADRB3 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
33 Cystine/glutamate transporter SLC7A11 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
1313 Lactoylglutathione lyase GLO1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
822 Aldose reductase AKR1B1 0.0014
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6432 Transporter snf 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
997 Protein kinase C beta type PRKCB 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
3809 Estrogen-related receptor gamma ESRRG 0.0007
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
869 Estrogen receptor beta ESR2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
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