DT-Web

DB00689 - Cephaloglycin


Identification
Name Cephaloglycin
Accession Number DB00689 (APRD00858)
Type small molecule
Description A cephalorsporin antibiotic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 405.425
Groups approved
Monoisotopic Weight 405.099456045
Pharmacology
Indication For treatment of severe infections caused by susceptible bacteria.
Mechanism of action The bactericidal activity of cephaloglycin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Absorption Well absorbed following oral administration.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Probenecid Probenecid may increase the serum level of cephaloglycin.
Food Interactions Not Available

Targets


PbpA
Name PbpA
Gene Name pbpA
Pharmacological action yes
Actions antagonist
References
  • Lepage S, Lakaye B, Galleni M, Thamm I, Crine M, Groslambert S, Frere JM: Saturation of penicillin-binding protein 1 by beta-lactam antibiotics in growing cells of Bacillus licheniformis. Mol Microbiol. 1995 Apr;16(2):365-72. - Pubmed
DTHybrid score Not Available

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.1803

Predictions


Id Partner name Gene Name Score
833 Organic cation/carnitine transporter 1 SLC22A4 0.0431
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0376
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0361
6145 Solute carrier family 22 member 1 SLC22A1 0.0307
4119 Cytochrome P450 2D6 CYP2D6 0.0274
6144 Solute carrier family 22 member 2 SLC22A2 0.0269
1729 Solute carrier family 22 member 6 SLC22A6 0.0247
6147 Solute carrier family 22 member 3 SLC22A3 0.022
6142 Solute carrier family 22 member 8 SLC22A8 0.022
477 DNA topoisomerase 4 subunit A parC 0.0178
886 DNA topoisomerase 4 subunit A parC 0.0178
6226 DNA topoisomerase 4 subunit A parC 0.0178
4200 Cytochrome P450 1A2 CYP1A2 0.0177
404 DNA gyrase subunit A gyrA 0.0175
6224 DNA gyrase subunit A gyrA 0.0175
4512 Cytochrome P450 3A4 CYP3A4 0.0172
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0154
1588 Multidrug resistance protein 1 ABCB1 0.0153
159 Penicillin-binding protein 2B penA 0.0153
6121 Penicillin-binding protein 2B penA 0.0153
817 DNA topoisomerase 2-alpha TOP2A 0.0131
1024 Solute carrier family 22 member 11 SLC22A11 0.0128
862 Multidrug resistance-associated protein 1 ABCC1 0.0109
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
4757 Cytochrome P450 2C9 CYP2C9 0.0094
738 Monocarboxylate transporter 1 SLC16A1 0.0093
6010 Thiamine transporter 1 SLC19A2 0.0089
492 Histamine H1 receptor HRH1 0.0088
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
175 Thiamin pyrophosphokinase 1 TPK1 0.008
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
5718 Cytochrome P450 2A6 CYP2A6 0.0075
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
587 Serum albumin ALB 0.0072
6137 Multidrug resistance-associated protein 6 ABCC6 0.0066
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
6016 Cytochrome P450 2C19 CYP2C19 0.0064
4118 Cytochrome P450 3A5 CYP3A5 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
474 Acetylcholinesterase ACHE 0.0063
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
1757 Myeloperoxidase MPO 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.006
6106 Cytochrome P450 2C18 CYP2C18 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
318 Alpha-2A adrenergic receptor ADRA2A 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6030 Cytochrome P450 2B6 CYP2B6 0.0057
788 Creatine kinase M-type CKM 0.0057
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0056
6143 Solute carrier family 22 member 7 SLC22A7 0.0055
6024 Cytochrome P450 1A1 CYP1A1 0.0055
6107 Cytochrome P450 3A7 CYP3A7 0.0055
4924 Cytochrome P450 2C8 CYP2C8 0.0054
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0046
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
380 Cytochrome P450 17A1 CYP17A1 0.0042
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0042
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0038
3941 Amine oxidase [flavin-containing] A MAOA 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0036
6013 Cytochrome P450 2E1 CYP2E1 0.0036
5126 Arginase rocF 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
1341 Histamine H3 receptor HRH3 0.0034
124 Histamine H2 receptor HRH2 0.0034
499 Arginine decarboxylase ADC 0.0033
164 Histamine H4 receptor HRH4 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
556 Alpha-1A adrenergic receptor ADRA1A 0.0032
3923 Cholinesterase BCHE 0.0031
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
632 Alpha-1B adrenergic receptor ADRA1B 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
976 Platelet glycoprotein IX GP9 0.0025
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0025
20 Prostaglandin G/H synthase 1 PTGS1 0.0024
776 Bile salt export pump ABCB11 0.0023
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
7 Nitric oxide synthase, inducible NOS2 0.0019
357 Carbonic anhydrase 2 CA2 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
6151 Monocarboxylate transporter 10 SLC16A10 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
4604 Liver carboxylesterase 1 CES1 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0015
3810 Catechol O-methyltransferase COMT 0.0014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
2164 Multidrug resistance-associated protein 4 ABCC4 0.0013
163 D(1B) dopamine receptor DRD5 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
432 D(4) dopamine receptor DRD4 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
638 D(3) dopamine receptor DRD3 0.0012
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0012
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
6432 Transporter snf 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
23 D(1A) dopamine receptor DRD1 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
831 D(2) dopamine receptor DRD2 0.001
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.001
6141 Sodium/bile acid cotransporter SLC10A1 0.001
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0009
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
6148 Multidrug resistance-associated protein 7 ABCC10 0.0007
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