DT-Web

DB01332 - Ceftizoxime


Identification
Name Ceftizoxime
Accession Number DB01332
Type small molecule
Description A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 383.403
Groups approved
Monoisotopic Weight 383.035809931
Pharmacology
Indication For the treatment of infections due to susceptible strains of microorganisms.
Mechanism of action Ceftizoxime is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae. Ceftizoxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that ceftizoxime interferes with an autolysin inhibitor.
Absorption Not Available
Protein binding 30% protein bound
Biotransformation Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours.
Route of elimination Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours.
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Probenecid Probenecid may increase the serum level of ceftizoxime.
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


MecA PBP2' (penicillin binding protein 2')
Name MecA PBP2' (penicillin binding protein 2')
Gene Name mecA
Pharmacological action yes
Actions inhibitor
References
  • Leski TA, Tomasz A: Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. J Bacteriol. 2005 Mar;187(5):1815-24. - Pubmed
DTHybrid score Not Available
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name mrcA
Pharmacological action yes
Actions inhibitor
References
  • Shigi Y, Kojo H, Wakasugi M, Nishida M: Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillin-binding proteins. Antimicrob Agents Chemother. 1981 Mar;19(3):393-6. - Pubmed
DTHybrid score 0.6331
Penicillin-binding protein 1B
Name Penicillin-binding protein 1B
Gene Name mrcB
Pharmacological action yes
Actions inhibitor
References
  • Shigi Y, Kojo H, Wakasugi M, Nishida M: Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillin-binding proteins. Antimicrob Agents Chemother. 1981 Mar;19(3):393-6. - Pubmed
DTHybrid score 0.621
Peptidoglycan synthetase ftsI
Name Peptidoglycan synthetase ftsI
Gene Name ftsI
Pharmacological action yes
Actions inhibitor
References
  • Shigi Y, Kojo H, Wakasugi M, Nishida M: Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillin-binding proteins. Antimicrob Agents Chemother. 1981 Mar;19(3):393-6. - Pubmed
DTHybrid score 0.056

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate
References
  • Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. - Pubmed
DTHybrid score 0.4605

Predictions


Id Partner name Gene Name Score
5805 Penicillin-binding protein 1A ponA 0.6331
6185 Penicillin-binding protein 1A mrcA 0.6331
6799 Penicillin-binding protein 1A pbpA 0.6331
6186 Penicillin-binding protein 1B ponB 0.621
6822 Penicillin-binding protein 1b pbp1b 0.621
6844 Penicillin-binding protein 1b pbp1b 0.621
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.29
819 Penicillin-binding protein 4 dacB 0.2669
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.1912
633 Penicillin-binding proteins 1A/1B pbpA 0.1455
1729 Solute carrier family 22 member 6 SLC22A6 0.1113
867 Penicillin-binding protein 3 pbpC 0.1099
6119 Penicillin-binding protein 3 pbp3 0.1099
7154 Penicillin-binding protein 3 pbp3 0.1099
7157 Penicillin-binding protein 3 LMHCC_2184 0.1099
7162 Penicillin-binding protein 3 pbpB 0.1099
7172 Penicillin-binding protein 3 pbp3 0.1099
3760 Penicillin-binding protein 5 precursor dacA 0.1058
587 Serum albumin ALB 0.1017
6067 Penicillin binding protein 2a mecA 0.094
244 Angiotensin-converting enzyme ACE 0.0936
118 Organic cation/carnitine transporter 2 SLC22A5 0.0791
2385 Penicillin acylase Not Available 0.0782
6142 Solute carrier family 22 member 8 SLC22A8 0.0759
115 Penicillin-binding protein 2 mrdA 0.0618
6069 Penicillin-binding protein 2 mrdA 0.0618
6118 Penicillin-binding protein 2 penA 0.0618
6187 Penicillin-binding protein 2 pbpA 0.0618
6686 Penicillin-binding protein 2 pbp2 0.0618
6939 Penicillin-binding protein 2 mrdA 0.0618
7163 Penicillin-binding protein 2 pbpA 0.0618
1 Peptidoglycan synthetase ftsI ftsI 0.056
332 Beta-lactamase blaZ 0.0448
2478 Beta-lactamase ampC 0.0448
2613 Beta-lactamase ampC 0.0448
2635 Beta-lactamase ampC 0.0448
2700 Beta-lactamase penP 0.0448
5445 Beta-lactamase blaB 0.0448
6019 Beta-lactamase SHV-7 0.0448
6701 Beta-lactamase cphA 0.0448
1198 Serum paraoxonase/arylesterase 1 PON1 0.0409
6223 Penicillin-binding protein 1C pbpC 0.0409
1024 Solute carrier family 22 member 11 SLC22A11 0.0407
1405 Thiopurine S-methyltransferase TPMT 0.0238
1385 Angiotensin-converting enzyme 2 ACE2 0.0222
6143 Solute carrier family 22 member 7 SLC22A7 0.0219
2164 Multidrug resistance-associated protein 4 ABCC4 0.0206
1588 Multidrug resistance protein 1 ABCB1 0.017
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0166
4512 Cytochrome P450 3A4 CYP3A4 0.0156
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0123
1757 Myeloperoxidase MPO 0.0112
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
4119 Cytochrome P450 2D6 CYP2D6 0.0101
4604 Liver carboxylesterase 1 CES1 0.01
3923 Cholinesterase BCHE 0.0094
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0093
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
3810 Catechol O-methyltransferase COMT 0.0092
6016 Cytochrome P450 2C19 CYP2C19 0.0084
3917 Methylenetetrahydrofolate reductase MTHFR 0.0076
318 Alpha-2A adrenergic receptor ADRA2A 0.0071
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0068
4757 Cytochrome P450 2C9 CYP2C9 0.0059
159 Penicillin-binding protein 2B penA 0.0056
6121 Penicillin-binding protein 2B penA 0.0056
632 Alpha-1B adrenergic receptor ADRA1B 0.0056
4252 Penicillin-binding protein 5 dacA 0.0054
5482 Sialidase-2 NEU2 0.0052
556 Alpha-1A adrenergic receptor ADRA1A 0.005
707 72 kDa type IV collagenase MMP2 0.0048
738 Monocarboxylate transporter 1 SLC16A1 0.0048
509 Thymidine kinase TK 0.0046
570 Thymidine kinase TK 0.0046
2559 Thymidine kinase TK 0.0046
3430 Thymidine kinase tdk 0.0046
3518 Thymidine kinase TK 0.0046
5301 Thymidine kinase tdk 0.0046
5771 Thymidine kinase ORF36 0.0046
7009 Thymidine kinase ORF36 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
3426 Glutamine synthetase glnA 0.0041
3987 Glutamine synthetase GLUL 0.0041
338 DNA polymerase UL30 0.004
379 DNA polymerase UL54 0.004
697 DNA polymerase ORF28 0.004
2482 DNA polymerase 43 0.004
4104 DNA polymerase BALF5 0.004
65 Matrix metalloproteinase-9 Not Available 0.0039
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0039
20 Prostaglandin G/H synthase 1 PTGS1 0.0036
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0032
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0028
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
4924 Cytochrome P450 2C8 CYP2C8 0.0025
163 D(1B) dopamine receptor DRD5 0.0024
432 D(4) dopamine receptor DRD4 0.0023
6106 Cytochrome P450 2C18 CYP2C18 0.0022
638 D(3) dopamine receptor DRD3 0.0022
833 Organic cation/carnitine transporter 1 SLC22A4 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0021
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0021
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0021
4118 Cytochrome P450 3A5 CYP3A5 0.0021
23 D(1A) dopamine receptor DRD1 0.002
831 D(2) dopamine receptor DRD2 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0017
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0016
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0016
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0015
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0014
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0014
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0014
6024 Cytochrome P450 1A1 CYP1A1 0.0011
6107 Cytochrome P450 3A7 CYP3A7 0.0011
6030 Cytochrome P450 2B6 CYP2B6 0.0011
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0011
776 Bile salt export pump ABCB11 0.001
4200 Cytochrome P450 1A2 CYP1A2 0.0009
862 Multidrug resistance-associated protein 1 ABCC1 0.0009
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0009
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0008
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