DT-Web

DB01333 - Cefradine


Identification
Name Cefradine
Accession Number DB01333
Type small molecule
Description A semi-synthetic cephalosporin antibiotic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 349.405
Groups approved
Monoisotopic Weight 349.109626801
Pharmacology
Indication Not Available
Mechanism of action Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Over 90 percent of the drug is excreted unchanged in the urine within six hours.
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Probenecid Probenecid may increase the serum level of cefradine.
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name mrcA
Pharmacological action yes
Actions inhibitor
References
  • Sharma UK, Dwarakanath P, Banerjee N, Town C, Balganesh TS: Expression and characterization of the ponA (ORF I) gene of Haemophilus influenzae: functional complementation in a heterologous system. J Bacteriol. 1995 Dec;177(23):6745-50. - Pubmed
DTHybrid score 0.2992

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E, Bachmann K: A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. Drug Metab Dispos. 2008 Aug;36(8):1689-97. Epub 2008 May 27. - Pubmed
DTHybrid score 0.3007

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.2979
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate,inhibitor
References
  • Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadee W, Amidon GL: 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res. 1998 Aug;15(8):1154-9. - Pubmed
  • Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50. - Pubmed
  • Saito H, Okuda M, Terada T, Sasaki S, Inui K: Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther. 1995 Dec;275(3):1631-7. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics. J Pharmacol Exp Ther. 1997 Jun;281(3):1415-21. - Pubmed
DTHybrid score 0.5935
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
DTHybrid score 0.5699
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. - Pubmed
DTHybrid score 0.3672

Predictions


Id Partner name Gene Name Score
5805 Penicillin-binding protein 1A ponA 0.2992
6185 Penicillin-binding protein 1A mrcA 0.2992
6799 Penicillin-binding protein 1A pbpA 0.2992
543 Penicillin-binding protein 1B mrcB 0.2236
6186 Penicillin-binding protein 1B ponB 0.2236
6822 Penicillin-binding protein 1b pbp1b 0.2236
6844 Penicillin-binding protein 1b pbp1b 0.2236
244 Angiotensin-converting enzyme ACE 0.1788
6142 Solute carrier family 22 member 8 SLC22A8 0.1425
633 Penicillin-binding proteins 1A/1B pbpA 0.1279
587 Serum albumin ALB 0.1095
1588 Multidrug resistance protein 1 ABCB1 0.108
4119 Cytochrome P450 2D6 CYP2D6 0.1047
1024 Solute carrier family 22 member 11 SLC22A11 0.0872
4757 Cytochrome P450 2C9 CYP2C9 0.0846
6016 Cytochrome P450 2C19 CYP2C19 0.078
819 Penicillin-binding protein 4 dacB 0.0744
4200 Cytochrome P450 1A2 CYP1A2 0.0717
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0701
4118 Cytochrome P450 3A5 CYP3A5 0.0636
867 Penicillin-binding protein 3 pbpC 0.0616
6119 Penicillin-binding protein 3 pbp3 0.0616
7154 Penicillin-binding protein 3 pbp3 0.0616
7157 Penicillin-binding protein 3 LMHCC_2184 0.0616
7162 Penicillin-binding protein 3 pbpB 0.0616
7172 Penicillin-binding protein 3 pbp3 0.0616
833 Organic cation/carnitine transporter 1 SLC22A4 0.0562
4924 Cytochrome P450 2C8 CYP2C8 0.0562
6067 Penicillin binding protein 2a mecA 0.0558
6143 Solute carrier family 22 member 7 SLC22A7 0.0556
115 Penicillin-binding protein 2 mrdA 0.0497
6069 Penicillin-binding protein 2 mrdA 0.0497
6118 Penicillin-binding protein 2 penA 0.0497
6187 Penicillin-binding protein 2 pbpA 0.0497
6686 Penicillin-binding protein 2 pbp2 0.0497
6939 Penicillin-binding protein 2 mrdA 0.0497
7163 Penicillin-binding protein 2 pbpA 0.0497
20 Prostaglandin G/H synthase 1 PTGS1 0.0467
6107 Cytochrome P450 3A7 CYP3A7 0.0453
6145 Solute carrier family 22 member 1 SLC22A1 0.0449
3760 Penicillin-binding protein 5 precursor dacA 0.0432
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0408
6144 Solute carrier family 22 member 2 SLC22A2 0.0392
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0384
6030 Cytochrome P450 2B6 CYP2B6 0.0362
1385 Angiotensin-converting enzyme 2 ACE2 0.035
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0347
6013 Cytochrome P450 2E1 CYP2E1 0.0342
1757 Myeloperoxidase MPO 0.0338
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0335
404 DNA gyrase subunit A gyrA 0.0333
6224 DNA gyrase subunit A gyrA 0.0333
862 Multidrug resistance-associated protein 1 ABCC1 0.0318
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0313
290 Prostaglandin G/H synthase 2 PTGS2 0.031
332 Beta-lactamase blaZ 0.0309
2478 Beta-lactamase ampC 0.0309
2613 Beta-lactamase ampC 0.0309
2635 Beta-lactamase ampC 0.0309
2700 Beta-lactamase penP 0.0309
5445 Beta-lactamase blaB 0.0309
6019 Beta-lactamase SHV-7 0.0309
6701 Beta-lactamase cphA 0.0309
2164 Multidrug resistance-associated protein 4 ABCC4 0.0304
738 Monocarboxylate transporter 1 SLC16A1 0.0295
6024 Cytochrome P450 1A1 CYP1A1 0.0288
3923 Cholinesterase BCHE 0.0286
6147 Solute carrier family 22 member 3 SLC22A3 0.0276
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0275
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0272
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0263
5718 Cytochrome P450 2A6 CYP2A6 0.0262
477 DNA topoisomerase 4 subunit A parC 0.026
886 DNA topoisomerase 4 subunit A parC 0.026
6226 DNA topoisomerase 4 subunit A parC 0.026
492 Histamine H1 receptor HRH1 0.0246
234 Plasminogen PLG 0.0246
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
6106 Cytochrome P450 2C18 CYP2C18 0.0224
4604 Liver carboxylesterase 1 CES1 0.0222
338 DNA polymerase UL30 0.0215
379 DNA polymerase UL54 0.0215
697 DNA polymerase ORF28 0.0215
2482 DNA polymerase 43 0.0215
4104 DNA polymerase BALF5 0.0215
817 DNA topoisomerase 2-alpha TOP2A 0.0211
3917 Methylenetetrahydrofolate reductase MTHFR 0.021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0209
318 Alpha-2A adrenergic receptor ADRA2A 0.0208
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
1 Peptidoglycan synthetase ftsI ftsI 0.0179
4155 Peptidoglycan synthetase ftsI ftsI 0.0179
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0176
776 Bile salt export pump ABCB11 0.0175
592 Carbonic anhydrase 4 CA4 0.0173
556 Alpha-1A adrenergic receptor ADRA1A 0.0172
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0167
871 Glucocorticoid receptor NR3C1 0.0163
295 Carbonic anhydrase 1 CA1 0.016
357 Carbonic anhydrase 2 CA2 0.0159
1198 Serum paraoxonase/arylesterase 1 PON1 0.0152
6223 Penicillin-binding protein 1C pbpC 0.0152
159 Penicillin-binding protein 2B penA 0.0151
6121 Penicillin-binding protein 2B penA 0.0151
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0148
4252 Penicillin-binding protein 5 dacA 0.0146
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0142
632 Alpha-1B adrenergic receptor ADRA1B 0.0141
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0137
3811 Cytochrome P450 19A1 CYP19A1 0.0135
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0135
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0129
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0128
509 Thymidine kinase TK 0.0126
570 Thymidine kinase TK 0.0126
2559 Thymidine kinase TK 0.0126
3430 Thymidine kinase tdk 0.0126
3518 Thymidine kinase TK 0.0126
5301 Thymidine kinase tdk 0.0126
5771 Thymidine kinase ORF36 0.0126
7009 Thymidine kinase ORF36 0.0126
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0125
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0122
824 Sodium-dependent serotonin transporter SLC6A4 0.0118
3810 Catechol O-methyltransferase COMT 0.0116
3426 Glutamine synthetase glnA 0.0116
3987 Glutamine synthetase GLUL 0.0116
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0115
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0113
723 Cytosolic phospholipase A2 PLA2G4A 0.0111
629 Alpha-2B adrenergic receptor ADRA2B 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
136 Estrogen receptor ESR1 0.0107
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0105
713 Sodium-dependent dopamine transporter SLC6A3 0.0105
831 D(2) dopamine receptor DRD2 0.0104
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
6137 Multidrug resistance-associated protein 6 ABCC6 0.0099
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0099
474 Acetylcholinesterase ACHE 0.0096
6126 Carbonic anhydrase 7 CA7 0.0094
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
378 Alpha-2C adrenergic receptor ADRA2C 0.0092
1405 Thiopurine S-methyltransferase TPMT 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
502 5-hydroxytryptamine 2A receptor HTR2A 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
23 D(1A) dopamine receptor DRD1 0.0087
731 HIV-1 protease HIV-1 protease 0.0087
558 Solute carrier family 12 member 1 SLC12A1 0.0086
847 Mu-type opioid receptor OPRM1 0.0084
766 Beta-2 adrenergic receptor ADRB2 0.0083
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
175 Thiamin pyrophosphokinase 1 TPK1 0.008
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.008
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0079
3941 Amine oxidase [flavin-containing] A MAOA 0.0079
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0079
789 Alpha-1D adrenergic receptor ADRA1D 0.0078
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0078
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0078
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0078
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0077
320 5-hydroxytryptamine 1A receptor HTR1A 0.0075
638 D(3) dopamine receptor DRD3 0.0075
6136 Multidrug resistance-associated protein 5 ABCC5 0.0075
380 Cytochrome P450 17A1 CYP17A1 0.0074
707 72 kDa type IV collagenase MMP2 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
65 Matrix metalloproteinase-9 Not Available 0.0072
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.007
193 Beta-1 adrenergic receptor ADRB1 0.007
467 Delta-type opioid receptor OPRD1 0.007
260 Cytochrome P450 51 ERG11 0.0069
761 Cytochrome P450 51 ERG11 0.0069
3163 Cytochrome P450 51 cyp51 0.0069
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
6148 Multidrug resistance-associated protein 7 ABCC10 0.0067
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0067
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0067
432 D(4) dopamine receptor DRD4 0.0067
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0067
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0066
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0066
131 Synaptic vesicular amine transporter SLC18A2 0.0065
373 Transthyretin TTR 0.0065
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0065
6141 Sodium/bile acid cotransporter SLC10A1 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
2320 Thymidine kinase, cytosolic TK1 0.0062
614 Progesterone receptor PGR 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0062
737 Mineralocorticoid receptor NR3C2 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
1898 Cytochrome P450 1B1 CYP1B1 0.0059
163 D(1B) dopamine receptor DRD5 0.0058
124 Histamine H2 receptor HRH2 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
6031 Cytochrome P450 3A43 CYP3A43 0.0058
788 Creatine kinase M-type CKM 0.0057
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0056
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0055
696 Kappa-type opioid receptor OPRK1 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
275 Arachidonate 5-lipoxygenase ALOX5 0.0055
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0055
3932 Glutathione S-transferase A2 GSTA2 0.0053
590 5-hydroxytryptamine 2C receptor HTR2C 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
341 5-hydroxytryptamine 3 receptor HTR3A 0.0053
3939 Amine oxidase [flavin-containing] B MAOB 0.0052
5482 Sialidase-2 NEU2 0.0052
146 Androgen receptor AR 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.005
6149 Solute carrier family 22 member 10 SLC22A10 0.005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.005
6014 Cytochrome P450 2A13 CYP2A13 0.005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0049
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0048
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0048
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0047
24 Thymidylate synthase TMP1 0.0047
359 Thymidylate synthase TYMS 0.0047
2626 Thymidylate synthase thyA 0.0047
2729 Thymidylate synthase thyA 0.0047
5352 Thymidylate synthase THYA 0.0047
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0045
6131 Carbonic anhydrase 14 CA14 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0044
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0043
844 Epidermal growth factor receptor EGFR 0.0043
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0043
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
3947 Xanthine dehydrogenase/oxidase XDH 0.0042
885 5-hydroxytryptamine 1B receptor HTR1B 0.0042
828 Phenylalanine-4-hydroxylase PAH 0.0042
3109 Phenylalanine-4-hydroxylase phhA 0.0042
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0042
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0042
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6122 Carbonic anhydrase 3 CA3 0.0041
408 Riboflavin kinase RFK 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.004
6151 Monocarboxylate transporter 10 SLC16A10 0.004
29 Tubulin beta-1 chain TUBB1 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
725 5-hydroxytryptamine 1D receptor HTR1D 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0039
1341 Histamine H3 receptor HRH3 0.0039
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0039
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0039
164 Histamine H4 receptor HRH4 0.0039
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0039
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0039
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0039
6020 Aldehyde oxidase AOX1 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
4203 Histamine N-methyltransferase HNMT 0.0036
6182 Cytochrome P450 2J2 CYP2J2 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
1867 Major prion protein PRNP 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
5126 Arginase rocF 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0035
856 Vitamin D3 receptor VDR 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4773 Deoxycytidine kinase DCK 0.0035
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0035
811 Translocator protein TSPO 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
3007 Carbonic anhydrase 12 CA12 0.0034
4205 Carbonic anhydrase 9 CA9 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
70 Type-1 angiotensin II receptor AGTR1 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0033
499 Arginine decarboxylase ADC 0.0033
130 Prostacyclin synthase PTGIS 0.0033
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0032
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0032
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0032
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0032
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0032
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0032
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0032
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0031
6207 30S ribosomal protein S14 rpsN 0.0031
6209 30S ribosomal protein S19 rpsS 0.0031
6712 30S ribosomal protein S19 rpsS 0.0031
6726 30S ribosomal protein S19 rpsS 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
6168 Solute carrier family 22 member 16 SLC22A16 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.003
716 5-hydroxytryptamine 7 receptor HTR7 0.003
976 Platelet glycoprotein IX GP9 0.003
654 Flavin reductase BLVRB 0.0029
6218 Pannexin-1 PANX1 0.0029
1039 Histone deacetylase 9 HDAC9 0.0029
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0029
756 Sex hormone-binding globulin SHBG 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
6167 Organic solute transporter subunit beta OSTB 0.0028
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6166 Organic solute transporter subunit alpha OSTA 0.0028
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
6102 Arylamine N-acetyltransferase 2 NAT2 0.0028
1196 Complement decay-accelerating factor CD55 0.0027
436 5-hydroxytryptamine 2B receptor HTR2B 0.0027
1517 Beta-3 adrenergic receptor ADRB3 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
3685 Catabolite gene activator crp 0.0027
153 Dopamine beta-hydroxylase DBH 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
1050 Bile salt sulfotransferase SULT2A1 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
293 Gamma-glutamyl hydrolase GGH 0.0026
49 Endothelin B receptor EDNRB 0.0026
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0025
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0025
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0025
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0025
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0025
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0025
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2808 Chloramphenicol acetyltransferase 3 cat3 0.0024
1714 Mitogen-activated protein kinase 3 MAPK3 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
183 Vascular endothelial growth factor A VEGFA 0.0024
7 Nitric oxide synthase, inducible NOS2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
777 Tumor necrosis factor TNF 0.0023
1650 Heme carrier protein 1 SLC46A1 0.0023
869 Estrogen receptor beta ESR2 0.0023
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0023
4760 Mll3241 protein mll3241 0.0023
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
2417 Chloramphenicol acetyltransferase cat 0.0022
3278 Chloramphenicol acetyltransferase cat 0.0022
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0022
2810 Dr hemagglutinin structural subunit draA 0.0022
6220 Aryl hydrocarbon receptor AHR 0.0022
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1656 CYP2B protein CYP2B 0.0021
527 Prostacyclin receptor PTGIR 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
465 Calmodulin CALM1 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
6432 Transporter snf 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
1654 Interleukin-1 beta IL1B 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0018
1360 Sphingomyelin phosphodiesterase SMPD1 0.0018
4120 NADPH--cytochrome P450 reductase POR 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
4217 Telomerase reverse transcriptase TERT 0.0018
683 Potassium transporter GK0582 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
228 Beta platelet-derived growth factor receptor PDGFRB 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
365 Dihydrofolate reductase DHFR 0.0016
2381 Dihydrofolate reductase DFR1 0.0016
2833 Dihydrofolate reductase Not Available 0.0016
2931 Dihydrofolate reductase folA 0.0016
3544 Dihydrofolate reductase folA 0.0016
3682 Dihydrofolate reductase folA 0.0016
6642 Dihydrofolate reductase folA 0.0016
6756 Dihydrofolate reductase dfrA 0.0016
173 Toll-like receptor 7 TLR7 0.0016
1192 Sulfotransferase 1A1 SULT1A1 0.0016
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
3233 Bile acid receptor NR1H4 0.0015
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0015
494 Caspase-1 CASP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
634 Squalene monooxygenase SQLE 0.0015
7196 Squalene monooxygenase ERG1 0.0015
1507 Cytochrome c CYCS 0.0015
427 Substance-P receptor TACR1 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
1629 Transcription factor AP-1 JUN 0.0015
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1541 Metalloproteinase mmp20 0.0014
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0014
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0014
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0014
822 Aldose reductase AKR1B1 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
6085 Fatty acid-binding protein, intestinal FABP2 0.0013
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0013
4122 Histone deacetylase 2 HDAC2 0.0013
2077 Caspase-3 CASP3 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
16 Adenosine A1 receptor ADORA1 0.0012
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
1295 Fatty acid synthase FASN 0.0012
904 Glutathione S-transferase P GSTP1 0.0012
702 UMP-CMP kinase CMPK1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
2236 Casein kinase II subunit alpha CSNK2A1 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
1178 Adenosine A2a receptor ADORA2A 0.0011
2021 Thrombomodulin THBD 0.0011
239 Coagulation factor X F10 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
921 Glutamate receptor 2 GRIA2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
54 Prothrombin F2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
997 Protein kinase C beta type PRKCB 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
1970 Protein kinase C alpha type PRKCA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0009
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
5818 Folate receptor alpha FOLR1 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
3587 Gastrotropin FABP6 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
469 Annexin A1 ANXA1 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
1618 High affinity nerve growth factor receptor NTRK1 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3937 Fatty-acid amide hydrolase FAAH 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
3809 Estrogen-related receptor gamma ESRRG 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
563 Thyroid peroxidase TPO 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
823 Fibroblast growth factor receptor 2 FGFR2 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
319 Opioid receptor, sigma 1 OPRS1 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
174 Sigma 1-type opioid receptor SIGMAR1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
5934 Cytochrome P450 26A1 CYP26A1 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
3957 Adenosine deaminase ADA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
2207 Rhodopsin RHO 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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