DT-Web

DB00861 - Diflunisal


Identification
Name Diflunisal
Accession Number DB00861 (APRD00922, DB06895)
Type small molecule
Description Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 250.1976
Groups approved
Monoisotopic Weight 250.044150532
Pharmacology
Indication For symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
Mechanism of action The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues.
Absorption Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%. Peak plasma concentrations are achieved 2 - 3 hours following oral administration.
Protein binding At least 98 to 99% of diflunisal in plasma is bound to proteins.
Biotransformation Hepatic, primarily via glucuronide conjugation (90% of administered dose).
Route of elimination The drug is excreted in the urine as two soluble glucuronide conjugates accounting for about 90% of the administered dose. Little or no diflunisal is excreted in the feces.
Toxicity Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include drowsiness, nausea, vomiting, diarrhea, hyperventilation, tachycardia, sweating, tinnitus, disorientation, stupor, and coma. The lowest dose without the presence of other medicines which caused death was 15 grams.

Selective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of diflunisal. Short-term use does not appear to be associated with increased cardiovascular risk (except when used immediately following coronary artery bypass graft (CABG) surgery). Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Severe hepatic reactions, including cholestasis and/or jaundice, have been reported. May cause rash or hypersensitivity syndrome.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The NSAID, diflunisal, may increase the anticoagulant effect of acenocoumarol.
Alendronate Increased risk of gastric toxicity
Anisindione The NSAID, diflunisal, may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Dicumarol The NSAID, diflunisal, may increase the anticoagulant effect of dicumarol.
Eltrombopag Eltrombopag increases levels of Diflunisal via metabolism decrease.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Indomethacin Concomitant therapy with the two NSAIDs, indomethacin and diflunisal, increases the risk of NSAID-related adverse effects (e.g. GI ulcers, bleeds, increased blood pressure).
Lithium The NSAID, diflunisal, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Methotrexate The NSAID, diflunisal, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Probenecid Probenecid increases toxicity of diflunisal
Telmisartan Concomitant use of Telmisartan and Diflunisal may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol The NSAID, Diflunisal, may antagonize the antihypertensive effect of Timolol.
Trandolapril The NSAID, Diflunisal, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Diflunisal is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Diflunisal. Monitor for increased bleeding during concomitant thearpy.
Warfarin The antiplatelet effects of diflunisal may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.
Food Interactions
  • Food slightly delays rate of absorption with no effect on extent of absorption.
  • Avoid alcohol.
  • Take with food to reduce gastric irritation.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Cappon GD, Cook JC, Hurtt ME: Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol. 2003 Feb;68(1):47-56. - Pubmed
  • Jeske AH: COX-2 inhibitors and dental pain control. J Gt Houst Dent Soc. 1999 Nov;71(4):39-40. - Pubmed
  • Mao H, Hajduk PJ, Craig R, Bell R, Borre T, Fesik SW: Rational design of diflunisal analogues with reduced affinity for human serum albumin. J Am Chem Soc. 2001 Oct 31;123(43):10429-35. - Pubmed
  • Moore PA, Hersh EV: Celecoxib and rofecoxib. The role of COX-2 inhibitors in dental practice. J Am Dent Assoc. 2001 Apr;132(4):451-6. - Pubmed
  • Young JM, Panah S, Satchawatcharaphong C, Cheung PS: Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production. Inflamm Res. 1996 May;45(5):246-53. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5725
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action unknown
Actions inhibitor
References
  • Cappon GD, Cook JC, Hurtt ME: Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol. 2003 Feb;68(1):47-56. - Pubmed
  • Chen QH, Rao PN, Knaus EE: Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem. 2005 Apr 1;13(7):2459-68. - Pubmed
  • Young JM, Panah S, Satchawatcharaphong C, Cheung PS: Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production. Inflamm Res. 1996 May;45(5):246-53. - Pubmed
DTHybrid score 0.6249

Enzymes


UDP-glucuronosyltransferase 1-8
Name UDP-glucuronosyltransferase 1-8
Gene Name UGT1A8
Actions substrate
References
  • Cheng Z, Radominska-Pandya A, Tephly TR: Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10. Drug Metab Dispos. 1999 Oct;27(10):1165-70. - Pubmed
DTHybrid score 0.1312

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.3406

Carriers


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.3406

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.162
4512 Cytochrome P450 3A4 CYP3A4 0.1355
4924 Cytochrome P450 2C8 CYP2C8 0.1099
6142 Solute carrier family 22 member 8 SLC22A8 0.1005
6016 Cytochrome P450 2C19 CYP2C19 0.0879
4200 Cytochrome P450 1A2 CYP1A2 0.0842
1588 Multidrug resistance protein 1 ABCB1 0.0801
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0798
1024 Solute carrier family 22 member 11 SLC22A11 0.0731
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0671
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0668
4119 Cytochrome P450 2D6 CYP2D6 0.0554
6143 Solute carrier family 22 member 7 SLC22A7 0.053
275 Arachidonate 5-lipoxygenase ALOX5 0.0504
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0487
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0484
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0451
4118 Cytochrome P450 3A5 CYP3A5 0.0437
2164 Multidrug resistance-associated protein 4 ABCC4 0.0433
6013 Cytochrome P450 2E1 CYP2E1 0.0395
6024 Cytochrome P450 1A1 CYP1A1 0.0382
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0378
6030 Cytochrome P450 2B6 CYP2B6 0.0373
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0359
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0359
1181 Alpha-1-acid glycoprotein 1 ORM1 0.033
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.033
1757 Myeloperoxidase MPO 0.0327
6106 Cytochrome P450 2C18 CYP2C18 0.0307
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0303
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0302
5718 Cytochrome P450 2A6 CYP2A6 0.0302
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.03
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0292
1275 Estrogen sulfotransferase SULT1E1 0.028
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0277
738 Monocarboxylate transporter 1 SLC16A1 0.0271
118 Organic cation/carnitine transporter 2 SLC22A5 0.0262
862 Multidrug resistance-associated protein 1 ABCC1 0.0256
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.024
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0227
891 Dihydropteroate synthase folP 0.0226
5359 Dihydropteroate synthase folP 0.0226
7175 Dihydropteroate synthase sulI 0.0226
6107 Cytochrome P450 3A7 CYP3A7 0.022
3312 Fatty acid-binding protein, brain FABP7 0.0217
6258 Protein S100-A7 S100A7 0.0191
146 Androgen receptor AR 0.0189
2183 Fatty acid-binding protein, adipocyte FABP4 0.0186
1159 Interleukin-6 IL6 0.0185
578 Endothelin-1 receptor EDNRA 0.0182
6145 Solute carrier family 22 member 1 SLC22A1 0.0179
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0178
3923 Cholinesterase BCHE 0.0176
633 Penicillin-binding proteins 1A/1B pbpA 0.0173
645 Penicillin-binding protein 1A mrcA 0.0172
5805 Penicillin-binding protein 1A ponA 0.0172
6185 Penicillin-binding protein 1A mrcA 0.0172
6799 Penicillin-binding protein 1A pbpA 0.0172
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0168
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0167
723 Cytosolic phospholipase A2 PLA2G4A 0.0167
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0163
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.016
1898 Cytochrome P450 1B1 CYP1B1 0.0156
672 Prostaglandin F2-alpha receptor PTGFR 0.0155
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0154
696 Kappa-type opioid receptor OPRK1 0.0153
6141 Sodium/bile acid cotransporter SLC10A1 0.0153
558 Solute carrier family 12 member 1 SLC12A1 0.0152
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0151
847 Mu-type opioid receptor OPRM1 0.0149
543 Penicillin-binding protein 1B mrcB 0.0149
6186 Penicillin-binding protein 1B ponB 0.0149
6822 Penicillin-binding protein 1b pbp1b 0.0149
6844 Penicillin-binding protein 1b pbp1b 0.0149
467 Delta-type opioid receptor OPRD1 0.0145
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0144
6541 Peptostreptococcal albumin-binding protein pab 0.0142
776 Bile salt export pump ABCB11 0.0142
592 Carbonic anhydrase 4 CA4 0.0141
4604 Liver carboxylesterase 1 CES1 0.0141
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.014
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
3811 Cytochrome P450 19A1 CYP19A1 0.0138
295 Carbonic anhydrase 1 CA1 0.0133
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
703 NADPH azoreductase azr 0.0132
6043 Putative G-protein coupled receptor 44 GPR44 0.0128
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0128
1507 Cytochrome c CYCS 0.0127
357 Carbonic anhydrase 2 CA2 0.0125
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0124
1039 Histone deacetylase 9 HDAC9 0.0124
850 Vasopressin V1b receptor AVPR1B 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0121
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0121
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.012
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0118
777 Tumor necrosis factor TNF 0.0117
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0116
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0116
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0116
594 Thyroxine-binding globulin SERPINA7 0.0115
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0113
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0113
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0113
3809 Estrogen-related receptor gamma ESRRG 0.0112
3639 Thymidine phosphorylase deoA 0.0111
3936 Thymidine phosphorylase TYMP 0.0111
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0111
758 Thyroid hormone receptor alpha THRA 0.011
1 Peptidoglycan synthetase ftsI ftsI 0.011
4155 Peptidoglycan synthetase ftsI ftsI 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
267 Plasminogen activator inhibitor 1 SERPINE1 0.011
6144 Solute carrier family 22 member 2 SLC22A2 0.011
6102 Arylamine N-acetyltransferase 2 NAT2 0.0108
185 Vasopressin V1a receptor AVPR1A 0.0107
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0106
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0106
346 Thyroid hormone receptor beta-1 THRB 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
6085 Fatty acid-binding protein, intestinal FABP2 0.0104
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0103
6221 Steroid hormone receptor ERR1 ESRRA 0.0099
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0098
1439 Lactotransferrin LTF 0.0098
2211 Fatty acid-binding protein, heart FABP3 0.0098
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0097
6033 High affinity interleukin-8 receptor A CXCR1 0.0096
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0095
70 Type-1 angiotensin II receptor AGTR1 0.0094
566 Serotransferrin TF 0.0094
3937 Fatty-acid amide hydrolase FAAH 0.0094
6220 Aryl hydrocarbon receptor AHR 0.0094
2236 Casein kinase II subunit alpha CSNK2A1 0.0094
6149 Solute carrier family 22 member 10 SLC22A10 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0092
130 Prostacyclin synthase PTGIS 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
2853 14 kDa fatty acid-binding protein Not Available 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0088
817 DNA topoisomerase 2-alpha TOP2A 0.0087
459 Retinoic acid receptor RXR-alpha RXRA 0.0087
1714 Mitogen-activated protein kinase 3 MAPK3 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
115 Penicillin-binding protein 2 mrdA 0.0086
6069 Penicillin-binding protein 2 mrdA 0.0086
6118 Penicillin-binding protein 2 penA 0.0086
6187 Penicillin-binding protein 2 pbpA 0.0086
6686 Penicillin-binding protein 2 pbp2 0.0086
6939 Penicillin-binding protein 2 mrdA 0.0086
7163 Penicillin-binding protein 2 pbpA 0.0086
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0086
136 Estrogen receptor ESR1 0.0084
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
1648 Elastin ELN 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
869 Estrogen receptor beta ESR2 0.0079
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
6136 Multidrug resistance-associated protein 5 ABCC5 0.0079
183 Vascular endothelial growth factor A VEGFA 0.0079
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0077
502 5-hydroxytryptamine 2A receptor HTR2A 0.0077
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
3947 Xanthine dehydrogenase/oxidase XDH 0.0075
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0074
1650 Heme carrier protein 1 SLC46A1 0.0074
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0073
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
831 D(2) dopamine receptor DRD2 0.0069
320 5-hydroxytryptamine 1A receptor HTR1A 0.0069
2320 Thymidine kinase, cytosolic TK1 0.0069
2981 Phospholipase A2, membrane associated PLA2G2A 0.0068
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
6137 Multidrug resistance-associated protein 6 ABCC6 0.0067
492 Histamine H1 receptor HRH1 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
36 Insulin receptor INSR 0.0066
811 Translocator protein TSPO 0.0065
489 Monocarboxylate transporter 2 SLC16A7 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
199 Monocarboxylate transporter 8 SLC16A2 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
3932 Glutathione S-transferase A2 GSTA2 0.0063
6148 Multidrug resistance-associated protein 7 ABCC10 0.0063
822 Aldose reductase AKR1B1 0.0062
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0061
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0061
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
705 Glutamate receptor 1 GRIA1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
756 Sex hormone-binding globulin SHBG 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
23 D(1A) dopamine receptor DRD1 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
833 Organic cation/carnitine transporter 1 SLC22A4 0.0059
1656 CYP2B protein CYP2B 0.0058
3917 Methylenetetrahydrofolate reductase MTHFR 0.0058
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0058
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0058
6500 Phospholipase A2 PLA2G1B 0.0057
33 Cystine/glutamate transporter SLC7A11 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0055
556 Alpha-1A adrenergic receptor ADRA1A 0.0055
614 Progesterone receptor PGR 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6131 Carbonic anhydrase 14 CA14 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
1867 Major prion protein PRNP 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
24 Thymidylate synthase TMP1 0.0052
359 Thymidylate synthase TYMS 0.0052
2626 Thymidylate synthase thyA 0.0052
2729 Thymidylate synthase thyA 0.0052
5352 Thymidylate synthase THYA 0.0052
65 Matrix metalloproteinase-9 Not Available 0.0052
244 Angiotensin-converting enzyme ACE 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
438 Taste receptor type 1 member 2 TAS1R2 0.0051
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6103 Arylamine N-acetyltransferase 1 NAT1 0.005
2021 Thrombomodulin THBD 0.005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
819 Penicillin-binding protein 4 dacB 0.0048
871 Glucocorticoid receptor NR3C1 0.0048
6151 Monocarboxylate transporter 10 SLC16A10 0.0048
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0048
823 Fibroblast growth factor receptor 2 FGFR2 0.0047
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0047
3382 Glycolipid transfer protein GLTP 0.0046
707 72 kDa type IV collagenase MMP2 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6207 30S ribosomal protein S14 rpsN 0.0045
6209 30S ribosomal protein S19 rpsS 0.0045
6712 30S ribosomal protein S19 rpsS 0.0045
6726 30S ribosomal protein S19 rpsS 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
3760 Penicillin-binding protein 5 precursor dacA 0.0045
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
737 Mineralocorticoid receptor NR3C2 0.0044
3601 Dihydropteroate synthase 1 folP1 0.0044
3807 Dihydropteroate synthase 1 folP1 0.0044
3808 Dihydropteroate synthase 2 folP2 0.0044
6147 Solute carrier family 22 member 3 SLC22A3 0.0044
663 Solute carrier family 12 member 4 SLC12A4 0.0044
53 Solute carrier family 12 member 5 SLC12A5 0.0044
6014 Cytochrome P450 2A13 CYP2A13 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
5698 Riboflavin synthase alpha chain ribE 0.0043
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0042
844 Epidermal growth factor receptor EGFR 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
291 Nitric-oxide synthase, endothelial NOS3 0.0041
310 Solute carrier family 12 member 2 SLC12A2 0.0041
632 Alpha-1B adrenergic receptor ADRA1B 0.0041
7 Nitric oxide synthase, inducible NOS2 0.0041
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
3426 Glutamine synthetase glnA 0.004
3987 Glutamine synthetase GLUL 0.004
4161 Furin FURIN 0.004
6228 Nuclear receptor coactivator 1 NCOA1 0.004
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
1198 Serum paraoxonase/arylesterase 1 PON1 0.0039
6223 Penicillin-binding protein 1C pbpC 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0038
1192 Sulfotransferase 1A1 SULT1A1 0.0038
904 Glutathione S-transferase P GSTP1 0.0038
6042 Prostaglandin reductase 2 PTGR2 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
6241 Nuclear receptor coactivator 2 NCOA2 0.0036
595 Fibrinogen alpha chain FGA 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0035
1792 Tissue-type plasminogen activator PLAT 0.0035
908 Glutathione S-transferase theta-1 GSTT1 0.0034
273 Apoptosis regulator Bcl-2 BCL2 0.0034
3810 Catechol O-methyltransferase COMT 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
2207 Rhodopsin RHO 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
6677 Myelin P2 protein PMP2 0.0032
293 Gamma-glutamyl hydrolase GGH 0.0032
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0031
824 Sodium-dependent serotonin transporter SLC6A4 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
654 Flavin reductase BLVRB 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
1313 Lactoylglutathione lyase GLO1 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1025 Aquaporin-1 AQP1 0.0027
1405 Thiopurine S-methyltransferase TPMT 0.0027
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0027
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0027
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0027
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0027
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
122 P2Y purinoceptor 12 P2RY12 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
4773 Deoxycytidine kinase DCK 0.0026
6146 High affinity copper uptake protein 1 SLC31A1 0.0026
427 Substance-P receptor TACR1 0.0025
3941 Amine oxidase [flavin-containing] A MAOA 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
4192 DNA topoisomerase 2-beta TOP2B 0.0025
3814 Complement C1r subcomponent C1R 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
1629 Transcription factor AP-1 JUN 0.0024
6231 Pepsin A PGA3 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
68 Cannabinoid receptor 1 CNR1 0.0023
1618 High affinity nerve growth factor receptor NTRK1 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
2782 Complement C1s subcomponent C1S 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0022
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0022
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
789 Alpha-1D adrenergic receptor ADRA1D 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
6031 Cytochrome P450 3A43 CYP3A43 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
436 5-hydroxytryptamine 2B receptor HTR2B 0.002
1864 RET proto-oncogene RET 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.002
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.002
1992 Vitamin D-binding protein GC 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
1654 Interleukin-1 beta IL1B 0.0019
260 Cytochrome P450 51 ERG11 0.0019
761 Cytochrome P450 51 ERG11 0.0019
3163 Cytochrome P450 51 cyp51 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
468 Cytochrome P450 4A11 CYP4A11 0.0018
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0018
528 5-hydroxytryptamine 1E receptor HTR1E 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0018
6218 Pannexin-1 PANX1 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0017
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0016
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0016
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0016
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
716 5-hydroxytryptamine 7 receptor HTR7 0.0016
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0016
5818 Folate receptor alpha FOLR1 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
1374 Natriuretic peptides B NPPB 0.0015
228 Beta platelet-derived growth factor receptor PDGFRB 0.0015
1827 Gap junction alpha-1 protein GJA1 0.0015
1908 Vascular cell adhesion protein 1 VCAM1 0.0015
494 Caspase-1 CASP1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0015
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0015
504 Mast/stem cell growth factor receptor KIT 0.0014
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0014
725 5-hydroxytryptamine 1D receptor HTR1D 0.0014
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0014
465 Calmodulin CALM1 0.0014
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0014
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0014
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
885 5-hydroxytryptamine 1B receptor HTR1B 0.0014
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
2077 Caspase-3 CASP3 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
6459 Glycodelin PAEP 0.0013
6432 Transporter snf 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
193 Beta-1 adrenergic receptor ADRB1 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0012
4943 Cytochrome c6 petJ 0.0011
4954 Soluble cytochrome b558 Not Available 0.0011
4905 Cytochrome c2 Not Available 0.0011
4939 Cytochrome c2 cycA 0.0011
4964 Cytochrome c2 cycA 0.0011
4979 Cytochrome c2 cycA 0.0011
6673 Cytochrome c2 cycA 0.0011
4984 Neuroglobin NGB 0.0011
4994 Hemoglobin-like protein HbO glbO 0.0011
4934 Cytochrome c-551 nirM 0.0011
5218 Cytochrome c-551 nirM 0.0011
4942 Diheme cytochrome c napB napB 0.0011
4947 Bacterial hemoglobin vhb 0.0011
4925 Cytochrome c-type protein SHP shp 0.0011
4916 Cyanoglobin glbN 0.0011
4998 Hemoglobin-like protein yjbI yjbI 0.0011
4975 Cytochrome c-556 RPA3973 0.0011
4915 Cytochrome c-550 psbV 0.0011
4959 Cytochrome c-550 psbV 0.0011
5216 Cytochrome c-550 psbV 0.0011
4961 Hemophore HasA hasA 0.0011
5000 HemO hemO 0.0011
4936 Cytochrome c2 iso-2 Not Available 0.0011
4981 Iron-starvation protein PigA pigA 0.0011
4910 Cytoglobin CYGB 0.0011
644 Heme oxygenase 2 HMOX2 0.0011
4982 Heme oxygenase 2 pbsA2 0.0011
3116 Bacterioferritin bfr 0.0011
4906 Bacterioferritin bfr 0.0011
4965 Bacterioferritin bfr 0.0011
4909 CooA protein cooA 0.0011
4904 Cytochrome c family protein GSU1996 0.0011
4976 Apocytochrome f petA 0.0011
6407 Apocytochrome f petA 0.0011
4935 Cytochrome c-554 cycA1 0.0011
4907 Cytochrome c-L moxG 0.0011
6865 Cytochrome c-L moxG 0.0011
4971 Nonaheme cytochrome c hmcA 0.0011
4937 Cytochrome oxidase subunit II rcoxA 0.0011
4764 Cytochrome P450 165C4 CYP165C4 0.0011
4989 Cytochrome c551 peroxidase ccp 0.0011
5222 Cytochrome c551 peroxidase ccpA 0.0011
4931 Cytochrome P450 167A1 CYP167A1 0.0011
4926 Heme-based aerotactic transducer hemAT hemAT 0.0011
4999 Cytochrome P450 165B3 CYP165B3 0.0011
4972 P450cin cinA 0.0011
4960 Putative cytochrome P450-family protein SCO7417 0.0011
4993 Hydroxylamine oxidoreductase hao1 0.0011
4903 Methyl-accepting chemotaxis protein Tar4 0.0011
4952 Catalase/peroxidase katA 0.0011
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0011
4922 Cytochrome c, putative SO_4144 0.0011
3093 Catalase HPII katE 0.0011
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0011
318 Alpha-2A adrenergic receptor ADRA2A 0.001
997 Protein kinase C beta type PRKCB 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
1970 Protein kinase C alpha type PRKCA 0.001
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0009
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0009
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0009
4920 Peroxidase/catalase katG 0.0009
921 Glutamate receptor 2 GRIA2 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0009
2119 Cytochrome b5 CYB5A 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
4037 Hypothetical protein GPX1 0.0009
4297 Hypothetical protein SP_1951 0.0009
4521 Hypothetical protein BC_2969 0.0009
4540 Hypothetical protein TM_1070 0.0009
4555 Hypothetical protein MT1739 0.0009
4569 Hypothetical protein mshD 0.0009
4578 Hypothetical protein PA3270 0.0009
4747 Hypothetical protein PA3967 0.0009
5177 Hypothetical protein TM_0096 0.0009
5194 Hypothetical protein PA1204 0.0009
5240 Hypothetical protein Rv2991 0.0009
5370 Hypothetical protein TM_1158 0.0009
5710 Hypothetical protein Tb927.5.1360 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
4990 PpcA ppcA 0.0008
378 Alpha-2C adrenergic receptor ADRA2C 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
4988 Sulfite oxidase, mitochondrial SUOX 0.0008
1184 Interferon beta IFNB1 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0008
3375 Acidic cytochrome c3 Not Available 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
3587 Gastrotropin FABP6 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
766 Beta-2 adrenergic receptor ADRB2 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
3102 Flavohemoprotein hmp 0.0007
4969 Flavohemoprotein hmp 0.0007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
518 Peroxidase/catalase T katG 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
3127 Nitrite reductase nirS 0.0007
3284 Nitrite reductase nirS 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
3221 Cytochrome c4 cc4 0.0007
605 Fumarate reductase flavoprotein subunit frdA 0.0007
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0007
3673 Fumarate reductase flavoprotein subunit fccA 0.0007
4912 Fumarate reductase flavoprotein subunit ifcA 0.0007
6549 Fumarate reductase flavoprotein subunit frdA 0.0007
2972 6-deoxyerythronolide B hydroxylase eryF 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
124 Histamine H2 receptor HRH2 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
358 Cystathionine beta-synthase CBS 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
693 Hemoglobin subunit beta HBB 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
2430 Chondroitinase B cslB 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2427 Ferrichrome-iron receptor fhuA 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
2298 Cytochrome P450-cam camC 0.0005
5961 Insulin INS 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
6755 Poliovirus receptor PVR 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
163 D(1B) dopamine receptor DRD5 0.0004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
432 D(4) dopamine receptor DRD4 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
638 D(3) dopamine receptor DRD3 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
952 Dipeptidyl peptidase 4 DPP4 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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