DT-Web

DB06813 - Pralatrexate


Identification
Name Pralatrexate
Accession Number DB06813
Type small molecule
Description Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 477.4726
Groups approved
Monoisotopic Weight 477.176066881
Pharmacology
Indication Treatment of relapsed or refractory peripheral T-cell lymphoma.
Mechanism of action The selectivity of pralatrexate for cancer cells is based upon the observation that cancer cells generally have an overexpression of reduced folate carrier protein-1 (RTC-1) compared to normal somatic cells. This carrier protein allows the entrance of pralatrexate into the cell. Upon entering the cell, folypolyglutamate synthase FPGS catalyzes the polyglutamination of pralatrexate so that it is retained inside the cell. Once inside, pralatrexate competitively inhibits dihydrofolate reductase (DHFR) and thymidylate synthase. Subsequent depletion of thymidine monophosphate (TMP) occurs so that the cancer cell is unable to synthesize DNA and RNA. As a result, the cancer cell cannot proliferate and is forced to undergo apoptosis. Pralatrexate is more effective against cells that are actively dividing.
Absorption Pralatrexate demonstrates linear pharmacokinetics with a multiphasic decline with both diasteromers over dose range of 30-325 mg/m^2. Bioavailability, nonformulated preparation = 13 - 20%
Protein binding 67 - 86% bound to plasma protein, albumin is the major binder. Does not significantly displace substrates from proteins.
Biotransformation No involvement of CYP450 enzyme system or glucuronidases.
Route of elimination 35% of drug is excreted unchanged in the urine (no difference between R- and S- pralatrexate). May be some net renal tubular excretion.
Toxicity Mucositis is the dose-limiting toxicity. Folic acid and vitamin B12 supplements do not prevent mucositis from happening.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Belatacept Increased immunosuppresive effects and risk of infection. Monitor for adverse effects .
Celecoxib NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Denosumab Increased immunosuppresive effects and risk of infection. Monitor for adverse effects .
Diclofenac NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Diflunisal NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Etodolac NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Fenoprofen NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Flurbiprofen NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Ibuprofen NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Indomethacin NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Meclofenamic acid NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Meloxicam NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Nabumetone NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Naproxen NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Oxaprozin NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Palifermin Increases the toxicity of pralatrexate. Avoid concomitant therapy or do not use palifermin within 24 hours after administration of pralatrexate.
Piroxicam NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Probenecid Decreases renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects.
Sulfamethoxazole Decreases renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects.
Sulindac NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Tolmetin NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Food Interactions Not Available

Targets


Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name DHFR
Pharmacological action yes
Actions inhibitor
References
  • Shimanovsky A, Dasanu CA: Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. Expert Opin Pharmacother. 2013 Mar;14(4):515-23. doi: 10.1517/14656566.2013.770474. Epub 2013 Feb 14. - Pubmed
DTHybrid score 1.1729
Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Pharmacological action yes
Actions inhibitor
References
  • Shimanovsky A, Dasanu CA: Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. Expert Opin Pharmacother. 2013 Mar;14(4):515-23. doi: 10.1517/14656566.2013.770474. Epub 2013 Feb 14. - Pubmed
DTHybrid score 0.8002

Enzymes


Folylpolyglutamate synthase, mitochondrial
Name Folylpolyglutamate synthase, mitochondrial
Gene Name FPGS
Actions substrate
References
  • Shimanovsky A, Dasanu CA: Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. Expert Opin Pharmacother. 2013 Mar;14(4):515-23. doi: 10.1517/14656566.2013.770474. Epub 2013 Feb 14. - Pubmed
DTHybrid score 0.4564

Transporters


Folate transporter 1
Name Folate transporter 1
Gene Name Not Available
Actions substrate
References
  • Gonen N, Assaraf YG: Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210. doi: 10.1016/j.drup.2012.07.002. Epub 2012 Aug 23. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2381 Dihydrofolate reductase DFR1 1.1729
2833 Dihydrofolate reductase Not Available 1.1729
2931 Dihydrofolate reductase folA 1.1729
3544 Dihydrofolate reductase folA 1.1729
3682 Dihydrofolate reductase folA 1.1729
6642 Dihydrofolate reductase folA 1.1729
6756 Dihydrofolate reductase dfrA 1.1729
24 Thymidylate synthase TMP1 0.8002
2626 Thymidylate synthase thyA 0.8002
2729 Thymidylate synthase thyA 0.8002
5352 Thymidylate synthase THYA 0.8002
6236 Trimethoprim-sensitive dihydrofolate reductase dfrB 0.0961
3639 Thymidine phosphorylase deoA 0.0784
3936 Thymidine phosphorylase TYMP 0.0784
1650 Heme carrier protein 1 SLC46A1 0.0482
1124 Sepiapterin reductase SPR 0.0413
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.038
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.031
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0292
4773 Deoxycytidine kinase DCK 0.0276
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.026
4757 Cytochrome P450 2C9 CYP2C9 0.0257
2164 Multidrug resistance-associated protein 4 ABCC4 0.0243
3611 Cytidine deaminase cdd 0.0234
3707 Cytidine deaminase cdd 0.0234
4211 Cytidine deaminase CDA 0.0234
2320 Thymidine kinase, cytosolic TK1 0.0231
5818 Folate receptor alpha FOLR1 0.0212
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.02
1588 Multidrug resistance protein 1 ABCB1 0.0196
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0187
293 Gamma-glutamyl hydrolase GGH 0.0184
4924 Cytochrome P450 2C8 CYP2C8 0.0183
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.018
1729 Solute carrier family 22 member 6 SLC22A6 0.0173
6148 Multidrug resistance-associated protein 7 ABCC10 0.0172
3917 Methylenetetrahydrofolate reductase MTHFR 0.0158
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0149
738 Monocarboxylate transporter 1 SLC16A1 0.0134
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0133
2567 Thymidylate synthase thyX thyX 0.0128
4275 PCZA361.16 Not Available 0.0128
4276 DNA polymerase III subunit epsilon dnaQ 0.0128
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0119
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0119
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0116
6143 Solute carrier family 22 member 7 SLC22A7 0.0116
4512 Cytochrome P450 3A4 CYP3A4 0.0115
2555 Pol polyprotein pol 0.0114
3242 Pol polyprotein gag-pol 0.0114
3471 Pol polyprotein gag-pro-pol 0.0114
5256 Pol polyprotein pol 0.0114
6469 Pol polyprotein gag-pol 0.0114
6565 Pol polyprotein Not Available 0.0114
1353 DNA topoisomerase 1 TOP1 0.0114
3552 DNA topoisomerase 1 topA 0.0114
6020 Aldehyde oxidase AOX1 0.0112
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0104
4604 Liver carboxylesterase 1 CES1 0.0101
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.01
2251 Thymidylate kinase tmk 0.0098
2254 Thymidylate kinase DTYMK 0.0098
3522 Thymidylate kinase tmk 0.0098
702 UMP-CMP kinase CMPK1 0.0098
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0094
587 Serum albumin ALB 0.0092
1024 Solute carrier family 22 member 11 SLC22A11 0.0089
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0087
6171 Solute carrier family 28 member 3 SLC28A3 0.0085
509 Thymidine kinase TK 0.0085
570 Thymidine kinase TK 0.0085
2559 Thymidine kinase TK 0.0085
3430 Thymidine kinase tdk 0.0085
3518 Thymidine kinase TK 0.0085
5301 Thymidine kinase tdk 0.0085
5771 Thymidine kinase ORF36 0.0085
7009 Thymidine kinase ORF36 0.0085
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0084
3361 Serpin B5 SERPINB5 0.0084
5694 Transcription antiterminator licT licT 0.0084
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0082
862 Multidrug resistance-associated protein 1 ABCC1 0.0082
4119 Cytochrome P450 2D6 CYP2D6 0.008
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.008
6142 Solute carrier family 22 member 8 SLC22A8 0.0077
56 Delta-aminolevulinic acid dehydratase ALAD 0.0067
2356 Delta-aminolevulinic acid dehydratase hemB 0.0067
3613 Delta-aminolevulinic acid dehydratase hemB 0.0067
3674 Delta-aminolevulinic acid dehydratase hemB 0.0067
4226 Uridine phosphorylase 2 UPP2 0.0061
4026 Aspartyl aminopeptidase DNPEP 0.0061
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0061
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0061
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0061
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0061
1047 Excitatory amino acid transporter 2 SLC1A2 0.0061
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0061
1912 Excitatory amino acid transporter 1 SLC1A3 0.0061
4016 Excitatory amino acid transporter 5 SLC1A7 0.0061
4019 Excitatory amino acid transporter 4 SLC1A6 0.0061
664 Glutamate decarboxylase 2 GAD2 0.0061
3890 Glutamate decarboxylase 2 GAD2 0.0061
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0061
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0061
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0061
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0061
4017 5-oxoprolinase OPLAH 0.0061
922 Glutamate receptor 4 GRIA4 0.0061
927 Metabotropic glutamate receptor 8 GRM8 0.0061
925 Metabotropic glutamate receptor 4 GRM4 0.0061
926 Metabotropic glutamate receptor 7 GRM7 0.0061
4020 Glutamyl aminopeptidase ENPEP 0.0061
4018 Glutamate receptor delta-2 subunit GRID2 0.0061
4027 Glutamate receptor delta-1 subunit GRID1 0.0061
4534 Cytohesin-2 CYTH2 0.0061
4225 Uridine phosphorylase 1 UPP1 0.0059
3668 Maltose-binding periplasmic protein precursor malE 0.0059
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0055
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0054
2592 Beta-galactosidase lacZ 0.0053
4200 Cytochrome P450 1A2 CYP1A2 0.0052
413 Amidophosphoribosyltransferase PPAT 0.0051
2515 Amidophosphoribosyltransferase purF 0.0051
3714 Amidophosphoribosyltransferase purF 0.0051
917 Glutaminase kidney isoform, mitochondrial GLS 0.005
5 Glutaminase liver isoform, mitochondrial GLS2 0.005
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.005
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.005
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.005
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.005
5261 Phosphoribosylformylglycinamidine synthase purL 0.005
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.005
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.005
315 Arginase-1 ARG1 0.005
625 Glutamate carboxypeptidase 2 FOLH1 0.0049
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0048
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0048
420 Glutamate decarboxylase 1 GAD1 0.0048
3900 Glutamate decarboxylase 1 GAD1 0.0048
665 Phosphoserine aminotransferase PSAT1 0.0048
4652 Phosphoserine aminotransferase serC 0.0048
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0048
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0047
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0047
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0046
916 Metabotropic glutamate receptor 1 GRM1 0.0046
1671 Excitatory amino acid transporter 3 SLC1A1 0.0044
923 Glutamate receptor 3 GRIA3 0.0044
3877 Growth-inhibiting protein 18 GIG18 0.0044
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0044
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0044
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
426 Aspartate aminotransferase, mitochondrial GOT2 0.0042
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0041
763 Tyrosine aminotransferase TAT 0.0041
5493 Tyrosine aminotransferase Not Available 0.0041
735 Alanine aminotransferase 1 GPT 0.0041
3904 Alanine aminotransferase 2 GPT2 0.0041
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.004
586 Aspartate aminotransferase, cytoplasmic GOT1 0.004
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.004
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.004
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0039
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0038
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0037
6013 Cytochrome P450 2E1 CYP2E1 0.0037
33 Cystine/glutamate transporter SLC7A11 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0036
3426 Glutamine synthetase glnA 0.0036
3987 Glutamine synthetase GLUL 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0035
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0034
6136 Multidrug resistance-associated protein 5 ABCC5 0.0033
6016 Cytochrome P450 2C19 CYP2C19 0.0033
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
6151 Monocarboxylate transporter 10 SLC16A10 0.0027
921 Glutamate receptor 2 GRIA2 0.0026
5718 Cytochrome P450 2A6 CYP2A6 0.0025
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0019
666 NADP-dependent malic enzyme ME1 0.0019
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0018
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0018
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0018
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0018
5332 MtdA bifunctional protein mtdA 0.0018
4403 Protein iolS iolS 0.0018
5322 Oxidoreductase ydhF ydhF 0.0018
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0018
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0018
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0018
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0018
5330 General stress protein 69 yhdN 0.0018
3778 NAD(P) transhydrogenase subunit beta pntB 0.0018
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0017
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0016
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0016
4582 Putative pteridine reductase 2 ptr2 0.0016
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0016
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0016
5073 Ferredoxin--NADP reductase petH 0.0016
5076 Ferredoxin--NADP reductase fpr 0.0016
5119 Ferredoxin--NADP reductase petH 0.0016
5121 Ferredoxin--NADP reductase fpr 0.0016
5328 Prostaglandin F synthase Tb11.02.2310 0.0016
989 L-xylulose reductase DCXR 0.0016
3446 NADP-dependent alcohol dehydrogenase adh 0.0016
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0016
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0016
2636 Shikimate dehydrogenase aroE 0.0016
3515 Shikimate dehydrogenase aroE 0.0016
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0016
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0016
2286 Isocitrate dehydrogenase [NADP] icd 0.0016
2302 Isocitrate dehydrogenase [NADP] icd 0.0016
2771 Isocitrate dehydrogenase [NADP] icd 0.0016
654 Flavin reductase BLVRB 0.0016
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0015
6297 Prostaglandin reductase 1 PTGR1 0.0015
4531 Putative ketoacyl reductase actIII 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
3062 Aspartate-semialdehyde dehydrogenase asd 0.0014
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
2675 Pteridine reductase 1 PTR1 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0014
2159 Quinone oxidoreductase CRYZ 0.0013
822 Aldose reductase AKR1B1 0.0013
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0012
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0009
4120 NADPH--cytochrome P450 reductase POR 0.0009
816 Biliverdin reductase A BLVRA 0.0006
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0006
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0006
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0006
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0005
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0005
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0005
328 Sorbitol dehydrogenase SORD 0.0005
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0005
597 Dihydropteridine reductase QDPR 0.0005
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0005
396 Alcohol dehydrogenase 4 ADH4 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0005
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0005
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0005
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0005
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0005
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0005
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0005
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0005
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0005
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0005
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0005
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0005
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0005
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0005
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0005
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0005
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0005
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0005
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0005
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0005
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0005
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0005
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0005
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0005
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0005
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0005
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0005
107 C-4 methylsterol oxidase SC4MOL 0.0005
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0005
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0005
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0005
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0005
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0005
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0005
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0005
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0005
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0005
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0005
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0005
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0005
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0005
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0005
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0005
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0005
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0005
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0005
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0005
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0005
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0005
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0005
3726 D-3-phosphoglycerate dehydrogenase serA 0.0005
4291 D-3-phosphoglycerate dehydrogenase serA 0.0005
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0005
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0005
729 GDP-L-fucose synthetase TSTA3 0.0005
3463 GDP-L-fucose synthetase fcl 0.0005
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0005
167 L-lactate dehydrogenase C chain LDHC 0.0005
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0005
206 3-keto-steroid reductase HSD17B7 0.0005
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0005
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0005
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0005
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0005
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0005
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0005
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0005
643 Peroxisomal bifunctional enzyme EHHADH 0.0005
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0005
34 7-dehydrocholesterol reductase DHCR7 0.0005
711 UDP-glucose 6-dehydrogenase UGDH 0.0005
3672 UDP-glucose 6-dehydrogenase hasB 0.0005
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0005
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0005
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0005
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
473 L-lactate dehydrogenase A chain LDHA 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0004
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0004
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0004
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
626 Cysteine dioxygenase type 1 CDO1 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
611 Retinal dehydrogenase 1 ALDH1A1 0.0004
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0004
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0004
627 11-cis retinol dehydrogenase RDH5 0.0004
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0004
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0004
569 Retinal dehydrogenase 2 ALDH1A2 0.0004
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0004
714 Glutathione reductase, mitochondrial GSR 0.0004
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0004
380 Cytochrome P450 17A1 CYP17A1 0.0004
279 Tyrosinase TYR 0.0004
517 Alcohol dehydrogenase 1C ADH1C 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0004
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0003
468 Cytochrome P450 4A11 CYP4A11 0.0003
3947 Xanthine dehydrogenase/oxidase XDH 0.0003
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