DT-Web: DB00788

Identification

Name

Naproxen

Accession Number

DB00788 (APRD01135)

Type

small molecule

Description

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

230.2592

Groups

approved

Monoisotopic Weight

230.094294314

Pharmacology

Indication

For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.

Mechanism of action

The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.

Absorption

Naproxen itself is rapidly and completely absorbed from the GI tract with an in vivo bioavailability of 95%. Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed resulting in higher peak plasma levels for a given dose. Food causes a slight decrease in the rate absorption.

Protein binding

At therapeutic levels naproxen is greater than 99% albumin-bound.

Biotransformation

Naproxen is extensively metabolized to 6-0-desmethyl naproxen and both parent and metabolites do not induce metabolizing enzymes.

Route of elimination

Not Available

Toxicity

ORAL (LD₅₀): Acute: 248 mg/kg [Rat]. 360 mg/kg [Mouse]. Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The NSAID, naproxen, may increase the anticoagulant effect of acenocoumarol.
Alendronate	Increased risk of gastric toxicity
Anisindione	The NSAID, naproxen, may increase the anticoagulant effect of anisindione.
Apixaban	Due to pharmacodynamic interaction, a 50-60% increase in anti-Factor Xa activity may be observed with concomitant therapy.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam	Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine	Monitor for nephrotoxicity
Dicumarol	The NSAID, naproxen, may increase the anticoagulant effect of dicumarol.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Lithium	The NSAID, naproxen, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Methotrexate	The NSAID, naproxen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate	NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Tapentadol	Increases the AUC of tapentadol by 17%. These changes are not considered clinically relevant and no change in dose is required.
Telmisartan	Concomitant use of Telmisartan and Naproxen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	The NSAID, Naproxen, may antagonize the antihypertensive effect of Timolol.
Trandolapril	The NSAID, Naproxen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Naproxen is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Naproxen. Monitor for increased bleeding during concomitant thearpy.
Triflusal	The metabolite of triflusal, 2-hydroxy-4-trifluoro-methyl-benzoic acid (HTB), impairs the serum protein binding of naproxen to the same extent as acetylsalisylic acid. Thus, the free fraction of glisentide may be increased. A dosage reduction may be required if used in combination.
Vilazodone	Increased risk of bleeding with concomitant use of NSAIDs with vilazodone.
Warfarin	The antiplatelet effects of naproxen may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.

Food Interactions

Take with food.
Avoid alcohol.
Take with a full glass of water.

Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Albertini R, Aimbire F, Villaverde AB, Silva JA Jr, Costa MS: COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy. Inflamm Res. 2007 Jun;56(6):228-9. - Pubmed Dhir A, Naidu PS, Kulkarni SK: Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure. 2007 Jun 29;. - Pubmed Kumar P, Padi SS, Naidu PS, Kumar A: Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. Fundam Clin Pharmacol. 2007 Jun;21(3):297-306. - Pubmed White WB: Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. Subcell Biochem. 2007;42:145-58. - Pubmed Hassan-Alin M, Naesdal J, Nilsson-Pieschl C, Langstrom G, Andersson T: Lack of Pharmacokinetic Interaction between Esomeprazole and the Nonsteroidal Anti-Inflammatory Drugs Naproxen and Rofecoxib in Healthy Subjects. Clin Drug Investig. 2005;25(11):731-40. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6224
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	yes
Actions	inhibitor
References	James MJ, Cook-Johnson RJ, Cleland LG: Selective COX-2 Inhibitors, Eicosanoid Synthesis and Clinical Outcomes: A Case Study of System Failure. Lipids. 2007 Jun 2;. - Pubmed
DTHybrid score	0.6972

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5377
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.395
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3821
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2608
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2439

Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score	0.2283
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score	0.3805

Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.2283
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.3805

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.3905
6016	Cytochrome P450 2C19	CYP2C19	0.2868
1588	Multidrug resistance protein 1	ABCB1	0.2602
4119	Cytochrome P450 2D6	CYP2D6	0.2196
4118	Cytochrome P450 3A5	CYP3A5	0.1639
6030	Cytochrome P450 2B6	CYP2B6	0.1471
6142	Solute carrier family 22 member 8	SLC22A8	0.1396
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1368
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1356
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1312
6013	Cytochrome P450 2E1	CYP2E1	0.1275
6024	Cytochrome P450 1A1	CYP1A1	0.1144
6107	Cytochrome P450 3A7	CYP3A7	0.1142
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1071
1024	Solute carrier family 22 member 11	SLC22A11	0.1035
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1012
2164	Multidrug resistance-associated protein 4	ABCC4	0.0915
5718	Cytochrome P450 2A6	CYP2A6	0.0904
6143	Solute carrier family 22 member 7	SLC22A7	0.085
862	Multidrug resistance-associated protein 1	ABCC1	0.0803
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0692
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0649
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0604
6106	Cytochrome P450 2C18	CYP2C18	0.0602
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0591
275	Arachidonate 5-lipoxygenase	ALOX5	0.0582
6145	Solute carrier family 22 member 1	SLC22A1	0.0523
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0512
6141	Sodium/bile acid cotransporter	SLC10A1	0.0498
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0497
776	Bile salt export pump	ABCB11	0.0495
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0481
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0445
118	Organic cation/carnitine transporter 2	SLC22A5	0.0429
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0421
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.041
1757	Myeloperoxidase	MPO	0.0406
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0395
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0395
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0389
146	Androgen receptor	AR	0.0386
1898	Cytochrome P450 1B1	CYP1B1	0.0384
891	Dihydropteroate synthase	folP	0.0359
5359	Dihydropteroate synthase	folP	0.0359
7175	Dihydropteroate synthase	sulI	0.0359
373	Transthyretin	TTR	0.0354
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0351
3811	Cytochrome P450 19A1	CYP19A1	0.0349
492	Histamine H1 receptor	HRH1	0.0342
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.034
696	Kappa-type opioid receptor	OPRK1	0.0337
6144	Solute carrier family 22 member 2	SLC22A2	0.0325
36	Insulin receptor	INSR	0.0325
847	Mu-type opioid receptor	OPRM1	0.0323
467	Delta-type opioid receptor	OPRD1	0.0322
738	Monocarboxylate transporter 1	SLC16A1	0.0321
136	Estrogen receptor	ESR1	0.0317
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0287
4604	Liver carboxylesterase 1	CES1	0.0286
817	DNA topoisomerase 2-alpha	TOP2A	0.0283
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0276
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0271
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.027
70	Type-1 angiotensin II receptor	AGTR1	0.0269
3923	Cholinesterase	BCHE	0.0266
6026	Alcohol dehydrogenase 6	ADH6	0.0266
404	DNA gyrase subunit A	gyrA	0.0265
6224	DNA gyrase subunit A	gyrA	0.0265
723	Cytosolic phospholipase A2	PLA2G4A	0.0262
824	Sodium-dependent serotonin transporter	SLC6A4	0.0261
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.026
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0257
6102	Arylamine N-acetyltransferase 2	NAT2	0.0256
6136	Multidrug resistance-associated protein 5	ABCC5	0.0256
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0251
33	Cystine/glutamate transporter	SLC7A11	0.025
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0249
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0248
831	D(2) dopamine receptor	DRD2	0.024
6085	Fatty acid-binding protein, intestinal	FABP2	0.0237
556	Alpha-1A adrenergic receptor	ADRA1A	0.0234
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0231
3941	Amine oxidase [flavin-containing] A	MAOA	0.023
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0227
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0225
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0224
6220	Aryl hydrocarbon receptor	AHR	0.0223
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0222
3312	Fatty acid-binding protein, brain	FABP7	0.0217
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0216
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0213
871	Glucocorticoid receptor	NR3C1	0.0208
558	Solute carrier family 12 member 1	SLC12A1	0.0208
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0206
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0203
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0202
3810	Catechol O-methyltransferase	COMT	0.0202
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0199
6043	Putative G-protein coupled receptor 44	GPR44	0.0197
632	Alpha-1B adrenergic receptor	ADRA1B	0.0195
6148	Multidrug resistance-associated protein 7	ABCC10	0.0195
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0195
904	Glutathione S-transferase P	GSTP1	0.0194
777	Tumor necrosis factor	TNF	0.0193
23	D(1A) dopamine receptor	DRD1	0.0191
6137	Multidrug resistance-associated protein 6	ABCC6	0.0191
477	DNA topoisomerase 4 subunit A	parC	0.0191
886	DNA topoisomerase 4 subunit A	parC	0.0191
6226	DNA topoisomerase 4 subunit A	parC	0.0191
756	Sex hormone-binding globulin	SHBG	0.019
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.019
811	Translocator protein	TSPO	0.0189
504	Mast/stem cell growth factor receptor	KIT	0.0189
1159	Interleukin-6	IL6	0.0185
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0182
833	Organic cation/carnitine transporter 1	SLC22A4	0.0182
320	5-hydroxytryptamine 1A receptor	HTR1A	0.018
5880	Thrombopoietin receptor	MPL	0.0178
295	Carbonic anhydrase 1	CA1	0.0178
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0178
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0177
766	Beta-2 adrenergic receptor	ADRB2	0.0177
592	Carbonic anhydrase 4	CA4	0.0176
26	Vascular endothelial growth factor receptor 3	FLT4	0.0174
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0174
6031	Cytochrome P450 3A43	CYP3A43	0.0173
633	Penicillin-binding proteins 1A/1B	pbpA	0.0173
731	HIV-1 protease	HIV-1 protease	0.0172
6147	Solute carrier family 22 member 3	SLC22A3	0.0172
645	Penicillin-binding protein 1A	mrcA	0.0172
5805	Penicillin-binding protein 1A	ponA	0.0172
6185	Penicillin-binding protein 1A	mrcA	0.0172
6799	Penicillin-binding protein 1A	pbpA	0.0172
468	Cytochrome P450 4A11	CYP4A11	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0169
318	Alpha-2A adrenergic receptor	ADRA2A	0.0168
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0167
32	Vascular endothelial growth factor receptor 1	FLT1	0.0167
459	Retinoic acid receptor RXR-alpha	RXRA	0.0165
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0164
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0161
869	Estrogen receptor beta	ESR2	0.016
244	Angiotensin-converting enzyme	ACE	0.016
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0158
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0157
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0156
3233	Bile acid receptor	NR1H4	0.0156
737	Mineralocorticoid receptor	NR3C2	0.0156
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0156
6033	High affinity interleukin-8 receptor A	CXCR1	0.0155
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0155
672	Prostaglandin F2-alpha receptor	PTGFR	0.0155
407	Vascular endothelial growth factor receptor 2	KDR	0.0154
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0153
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0151
789	Alpha-1D adrenergic receptor	ADRA1D	0.0151
357	Carbonic anhydrase 2	CA2	0.0151
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.015
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.015
2981	Phospholipase A2, membrane associated	PLA2G2A	0.015
590	5-hydroxytryptamine 2C receptor	HTR2C	0.015
380	Cytochrome P450 17A1	CYP17A1	0.015
543	Penicillin-binding protein 1B	mrcB	0.0149
6186	Penicillin-binding protein 1B	ponB	0.0149
6822	Penicillin-binding protein 1b	pbp1b	0.0149
6844	Penicillin-binding protein 1b	pbp1b	0.0149
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0145
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
2021	Thrombomodulin	THBD	0.0143
122	P2Y purinoceptor 12	P2RY12	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
273	Apoptosis regulator Bcl-2	BCL2	0.0142
3639	Thymidine phosphorylase	deoA	0.0142
3936	Thymidine phosphorylase	TYMP	0.0142
6149	Solute carrier family 22 member 10	SLC22A10	0.014
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0139
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0139
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0138
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0137
1648	Elastin	ELN	0.0136
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0135
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0133
1507	Cytochrome c	CYCS	0.0133
703	NADPH azoreductase	azr	0.0132
844	Epidermal growth factor receptor	EGFR	0.0132
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0131
117	Sterol O-acyltransferase 1	SOAT1	0.0129
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0129
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0128
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0127
130	Prostacyclin synthase	PTGIS	0.0127
4122	Histone deacetylase 2	HDAC2	0.0127
3587	Gastrotropin	FABP6	0.0125
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0125
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0125
3939	Amine oxidase [flavin-containing] B	MAOB	0.0124
6044	Serum paraoxonase/lactonase 3	PON3	0.0124
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0123
850	Vasopressin V1b receptor	AVPR1B	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.012
450	Muscarinic acetylcholine receptor M4	CHRM4	0.012
465	Calmodulin	CALM1	0.0119
1630	Integrin beta-2	ITGB2	0.0119
6138	Multidrug resistance protein 3	ABCB4	0.0117
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0117
338	DNA polymerase	UL30	0.0116
379	DNA polymerase	UL54	0.0116
697	DNA polymerase	ORF28	0.0116
2482	DNA polymerase	43	0.0116
4104	DNA polymerase	BALF5	0.0116
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0115
6014	Cytochrome P450 2A13	CYP2A13	0.0115
3947	Xanthine dehydrogenase/oxidase	XDH	0.0115
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0115
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0113
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0113
24	Thymidylate synthase	TMP1	0.0112
359	Thymidylate synthase	TYMS	0.0112
2626	Thymidylate synthase	thyA	0.0112
2729	Thymidylate synthase	thyA	0.0112
5352	Thymidylate synthase	THYA	0.0112
260	Cytochrome P450 51	ERG11	0.0112
761	Cytochrome P450 51	ERG11	0.0112
3163	Cytochrome P450 51	cyp51	0.0112
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0112
319	Opioid receptor, sigma 1	OPRS1	0.0112
2320	Thymidine kinase, cytosolic	TK1	0.0112
1050	Bile salt sulfotransferase	SULT2A1	0.0111
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
1	Peptidoglycan synthetase ftsI	ftsI	0.011
4155	Peptidoglycan synthetase ftsI	ftsI	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
594	Thyroxine-binding globulin	SERPINA7	0.011
1275	Estrogen sulfotransferase	SULT1E1	0.0109
183	Vascular endothelial growth factor A	VEGFA	0.0109
713	Sodium-dependent dopamine transporter	SLC6A3	0.0109
2211	Fatty acid-binding protein, heart	FABP3	0.0108
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0108
6126	Carbonic anhydrase 7	CA7	0.0107
185	Vasopressin V1a receptor	AVPR1A	0.0107
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
322	Vasopressin V2 receptor	AVPR2	0.0105
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0104
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0102
823	Fibroblast growth factor receptor 2	FGFR2	0.0102
1760	Aminopeptidase N	ANPEP	0.0101
6843	Aminopeptidase N	pepN	0.0101
758	Thyroid hormone receptor alpha	THRA	0.0101
6042	Prostaglandin reductase 2	PTGR2	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
1792	Tissue-type plasminogen activator	PLAT	0.0099
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0099
1439	Lactotransferrin	LTF	0.0098
1714	Mitogen-activated protein kinase 3	MAPK3	0.0097
482	Glycine receptor subunit alpha-1	GLRA1	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
1192	Sulfotransferase 1A1	SULT1A1	0.0096
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0096
566	Serotransferrin	TF	0.0094
193	Beta-1 adrenergic receptor	ADRB1	0.0094
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0093
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0093
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0093
614	Progesterone receptor	PGR	0.0093
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0092
6167	Organic solute transporter subunit beta	OSTB	0.0091
6166	Organic solute transporter subunit alpha	OSTA	0.0091
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0091
365	Dihydrofolate reductase	DHFR	0.0091
2381	Dihydrofolate reductase	DFR1	0.0091
2833	Dihydrofolate reductase	Not Available	0.0091
2931	Dihydrofolate reductase	folA	0.0091
3544	Dihydrofolate reductase	folA	0.0091
3682	Dihydrofolate reductase	folA	0.0091
6642	Dihydrofolate reductase	folA	0.0091
6756	Dihydrofolate reductase	dfrA	0.0091
346	Thyroid hormone receptor beta-1	THRB	0.009
1656	CYP2B protein	CYP2B	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.009
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0089
572	Integrin alpha-L	ITGAL	0.0089
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0089
16	Adenosine A1 receptor	ADORA1	0.0089
489	Monocarboxylate transporter 2	SLC16A7	0.0088
4116	Dihydropteroate synthetase	Not Available	0.0087
629	Alpha-2B adrenergic receptor	ADRA2B	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0086
115	Penicillin-binding protein 2	mrdA	0.0086
6069	Penicillin-binding protein 2	mrdA	0.0086
6118	Penicillin-binding protein 2	penA	0.0086
6187	Penicillin-binding protein 2	pbpA	0.0086
6686	Penicillin-binding protein 2	pbp2	0.0086
6939	Penicillin-binding protein 2	mrdA	0.0086
7163	Penicillin-binding protein 2	pbpA	0.0086
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0086
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0085
1650	Heme carrier protein 1	SLC46A1	0.0084
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0083
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0083
427	Substance-P receptor	TACR1	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
54	Prothrombin	F2	0.0082
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
4217	Telomerase reverse transcriptase	TERT	0.0081
6103	Arylamine N-acetyltransferase 1	NAT1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
6182	Cytochrome P450 2J2	CYP2J2	0.0079
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
232	Corticosteroid-binding globulin	SERPINA6	0.0079
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0079
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0079
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0079
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0078
571	Melatonin receptor type 1A	MTNR1A	0.0078
362	Melatonin receptor type 1B	MTNR1B	0.0078
638	D(3) dopamine receptor	DRD3	0.0078
1517	Beta-3 adrenergic receptor	ADRB3	0.0078
1313	Lactoylglutathione lyase	GLO1	0.0077
908	Glutathione S-transferase theta-1	GSTT1	0.0077
1178	Adenosine A2a receptor	ADORA2A	0.0076
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0076
3932	Glutathione S-transferase A2	GSTA2	0.0076
4221	Vascular endothelial growth factor	VEGF	0.0075
5816	Cadherin-5	CDH5	0.0075
3809	Estrogen-related receptor gamma	ESRRG	0.0075
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0074
705	Glutamate receptor 1	GRIA1	0.0074
1618	High affinity nerve growth factor receptor	NTRK1	0.0073
5626	Nucleoside diphosphate kinase B	NME2	0.0073
22	30S ribosomal protein S4	rpsD	0.0072
6714	30S ribosomal protein S4	rpsD	0.0072
663	Solute carrier family 12 member 4	SLC12A4	0.0072
53	Solute carrier family 12 member 5	SLC12A5	0.0072
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0072
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0072
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0072
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0072
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0071
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0071
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0071
94	5-hydroxytryptamine 4 receptor	HTR4	0.007
88	Retinoic acid receptor RXR-beta	RXRB	0.007
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.007
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.007
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.007
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0069
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0069
822	Aldose reductase	AKR1B1	0.0069
267	Plasminogen activator inhibitor 1	SERPINE1	0.0068
140	30S ribosomal protein S9	rpsI	0.0068
6719	30S ribosomal protein S9	rpsI	0.0068
6725	30S ribosomal protein S9	rpsI	0.0068
952	Dipeptidyl peptidase 4	DPP4	0.0067
310	Solute carrier family 12 member 2	SLC12A2	0.0067
199	Monocarboxylate transporter 8	SLC16A2	0.0067
4192	DNA topoisomerase 2-beta	TOP2B	0.0066
378	Alpha-2C adrenergic receptor	ADRA2C	0.0066
527	Prostacyclin receptor	PTGIR	0.0066
828	Phenylalanine-4-hydroxylase	PAH	0.0066
3109	Phenylalanine-4-hydroxylase	phhA	0.0066
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0066
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0066
1010	Cytochrome P450 51A1	CYP51A1	0.0066
4210	Toll-like receptor 4	TLR4	0.0066
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0065
6500	Phospholipase A2	PLA2G1B	0.0065
634	Squalene monooxygenase	SQLE	0.0065
7196	Squalene monooxygenase	ERG1	0.0065
661	ADP/ATP translocase 1	SLC25A4	0.0064
3808	Dihydropteroate synthase 2	folP2	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0064
3807	Dihydropteroate synthase 1	folP1	0.0064
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
1291	cAMP response element-binding protein	CREB1	0.0063
1039	Histone deacetylase 9	HDAC9	0.0063
133	Dihydropterate synthase	sulI	0.0063
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0063
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0063
6221	Steroid hormone receptor ERR1	ESRRA	0.0063
3856	Fibroblast growth factor receptor 3	FGFR3	0.0062
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0062
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0062
469	Annexin A1	ANXA1	0.0062
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0061
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0061
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0061
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0061
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0061
7	Nitric oxide synthase, inducible	NOS2	0.0061
1629	Transcription factor AP-1	JUN	0.0061
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.006
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.006
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.006
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.006
1541	Metalloproteinase	mmp20	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0059
5294	Nucleoside diphosphate kinase A	NME1	0.0058
284	DNA-directed RNA polymerase beta chain	rpoB	0.0058
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0058
2236	Casein kinase II subunit alpha	CSNK2A1	0.0057
6146	High affinity copper uptake protein 1	SLC31A1	0.0057
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0057
432	D(4) dopamine receptor	DRD4	0.0057
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0056
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0056
5787	Angiopoietin-1 receptor	TEK	0.0056
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0055
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0054
6131	Carbonic anhydrase 14	CA14	0.0054
162	Retinoic acid receptor gamma-1	RARG	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
780	Retinoic acid receptor RXR-gamma	RXRG	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0053
921	Glutamate receptor 2	GRIA2	0.0052
1867	Major prion protein	PRNP	0.0052
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
65	Matrix metalloproteinase-9	Not Available	0.0052
6020	Aldehyde oxidase	AOX1	0.0052
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
438	Taste receptor type 1 member 2	TAS1R2	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0051
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0051
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.005
229	Retinoic acid receptor beta	RARB	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
5934	Cytochrome P450 26A1	CYP26A1	0.0049
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0049
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0049
1053	BC269730_2	FADS1	0.0049
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0049
730	Retinoic acid receptor alpha	RARA	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0048
819	Penicillin-binding protein 4	dacB	0.0048
976	Platelet glycoprotein IX	GP9	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
716	5-hydroxytryptamine 7 receptor	HTR7	0.0047
291	Nitric-oxide synthase, endothelial	NOS3	0.0047
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0047
518	Peroxidase/catalase T	katG	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
1196	Complement decay-accelerating factor	CD55	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
707	72 kDa type IV collagenase	MMP2	0.0046
4238	50S ribosomal protein L4	rplD	0.0046
5578	50S ribosomal protein L4	rplD	0.0046
6173	50S ribosomal protein L4	rplD	0.0046
6219	50S ribosomal protein L4	rplD	0.0046
4692	A/G-specific adenine glycosylase	mutY	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
6207	30S ribosomal protein S14	rpsN	0.0045
6209	30S ribosomal protein S19	rpsS	0.0045
6712	30S ribosomal protein S19	rpsS	0.0045
6726	30S ribosomal protein S19	rpsS	0.0045
3760	Penicillin-binding protein 5 precursor	dacA	0.0045
3937	Fatty-acid amide hydrolase	FAAH	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
6218	Pannexin-1	PANX1	0.0044
293	Gamma-glutamyl hydrolase	GGH	0.0044
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0044
49	Endothelin B receptor	EDNRB	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0043
2207	Rhodopsin	RHO	0.0043
6151	Monocarboxylate transporter 10	SLC16A10	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
4237	50S ribosomal protein L22	rplV	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
4120	NADPH--cytochrome P450 reductase	POR	0.0042
165	FL cytokine receptor	FLT3	0.0041
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0041
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0041
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0041
29	Tubulin beta-1 chain	TUBB1	0.0041
124	Histamine H2 receptor	HRH2	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0041
6677	Myelin P2 protein	PMP2	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
408	Riboflavin kinase	RFK	0.0041
4203	Histamine N-methyltransferase	HNMT	0.0041
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0041
2808	Chloramphenicol acetyltransferase 3	cat3	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
5798	Mitogen-activated protein kinase 11	MAPK11	0.004
4103	Proteasome subunit beta type 2	PSMB2	0.004
4102	Proteasome subunit beta type 5	PSMB5	0.004
4101	Proteasome subunit beta type 1	PSMB1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
3426	Glutamine synthetase	glnA	0.004
3987	Glutamine synthetase	GLUL	0.004
4161	Furin	FURIN	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.004
1198	Serum paraoxonase/arylesterase 1	PON1	0.0039
6223	Penicillin-binding protein 1C	pbpC	0.0039
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0038
128	Adenine phosphoribosyltransferase	APRT	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
163	D(1B) dopamine receptor	DRD5	0.0038
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0037
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0037
1992	Vitamin D-binding protein	GC	0.0037
5353	Glutamate decarboxylase alpha	gadA	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
2417	Chloramphenicol acetyltransferase	cat	0.0037
3278	Chloramphenicol acetyltransferase	cat	0.0037
936	Ephrin type-A receptor 2	EPHA2	0.0037
760	Fibroblast growth factor 1	FGF1	0.0037
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0037
2810	Dr hemagglutinin structural subunit	draA	0.0037
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0037
1353	DNA topoisomerase 1	TOP1	0.0036
3552	DNA topoisomerase 1	topA	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0035
4226	Uridine phosphorylase 2	UPP2	0.0035
106	Cannabinoid receptor 2	CNR2	0.0035
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
712	Tubulin alpha chain	TUB1	0.0034
4773	Deoxycytidine kinase	DCK	0.0033
68	Cannabinoid receptor 1	CNR1	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
6122	Carbonic anhydrase 3	CA3	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
3007	Carbonic anhydrase 12	CA12	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
4205	Carbonic anhydrase 9	CA9	0.0033
4225	Uridine phosphorylase 1	UPP1	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
3957	Adenosine deaminase	ADA	0.0032
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0032
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0031
1864	RET proto-oncogene	RET	0.0031
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0031
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0031
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
751	Potassium channel subfamily K member 6	KCNK6	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
818	50S ribosomal protein L10	rplJ	0.003
413	Amidophosphoribosyltransferase	PPAT	0.003
2515	Amidophosphoribosyltransferase	purF	0.003
3714	Amidophosphoribosyltransferase	purF	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
6501	Fatty acid-binding protein, liver	FABP1	0.003
173	Toll-like receptor 7	TLR7	0.003
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.003
1374	Natriuretic peptides B	NPPB	0.003
1827	Gap junction alpha-1 protein	GJA1	0.003
1908	Vascular cell adhesion protein 1	VCAM1	0.003
654	Flavin reductase	BLVRB	0.0029
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0029
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
5818	Folate receptor alpha	FOLR1	0.0029
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0029
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
172	Potassium channel subfamily K member 1	KCNK1	0.0028
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0028
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
4311	tRNA	TRDMT1	0.0028
4325	tRNA	trmD	0.0028
4328	tRNA	trmD	0.0028
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0028
5431	Lipid binding protein	Not Available	0.0028
3616	Fatty acid-binding protein, epidermal	FABP5	0.0028
5433	UPF0230 protein TM_1468	TM_1468	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
474	Acetylcholinesterase	ACHE	0.0027
6432	Transporter	snf	0.0027
1025	Aquaporin-1	AQP1	0.0027
1405	Thiopurine S-methyltransferase	TPMT	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0027
3685	Catabolite gene activator	crp	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0026
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
239	Coagulation factor X	F10	0.0026
6174	50S ribosomal protein L32	rpmF	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0025
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0025
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0025
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0025
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0025
153	Dopamine beta-hydroxylase	DBH	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0025
3814	Complement C1r subcomponent	C1R	0.0024
5300	Antigen peptide transporter 1	TAP1	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0024
283	SEC14-like protein 2	SEC14L2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0023
814	Ryanodine receptor 1	RYR1	0.0023
4760	Mll3241 protein	mll3241	0.0023
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
1525	Heparin-binding growth factor 2	FGF2	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
6459	Glycodelin	PAEP	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3086	Plasmepsin-2	Not Available	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0022
6163	Copper-transporting ATPase 2	ATP7B	0.0022
6165	Copper-transporting ATPase 1	ATP7A	0.0022
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0022
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
563	Thyroid peroxidase	TPO	0.0021
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
859	Cellular retinoic acid-binding protein 2	CRABP2	0.002
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.002
268	Adenosine A2b receptor	ADORA2B	0.002
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
768	FK506-binding protein 1A	FKBP1A	0.002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.002
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.002
1820	Beta-nerve growth factor	NGF	0.002
6164	POU domain, class 5, transcription factor 1	POU5F1	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
1243	Cathepsin D	CTSD	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
867	Penicillin-binding protein 3	pbpC	0.0019
6119	Penicillin-binding protein 3	pbp3	0.0019
7154	Penicillin-binding protein 3	pbp3	0.0019
7157	Penicillin-binding protein 3	LMHCC_2184	0.0019
7162	Penicillin-binding protein 3	pbpB	0.0019
7172	Penicillin-binding protein 3	pbp3	0.0019
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0019
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
164	Histamine H4 receptor	HRH4	0.0018
161	Tubulin beta chain	TUBB	0.0018
312	Tubulin beta chain	TUB2	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
896	Glutathione S-transferase Mu 1	GSTM1	0.0018
4948	Cytochrome c-553	Not Available	0.0017
4923	Cytochrome c3	DvMF_2499	0.0017
4945	Cytochrome c3	Not Available	0.0017
4949	Cytochrome c3	DVU_3171	0.0017
4968	Cytochrome c3	cytc3	0.0017
4997	Cytochrome c3	SO_2727	0.0017
5219	Cytochrome c3	cyd	0.0017
3189	High-molecular-weight cytochrome c	hmcA	0.0017
4902	Nine-heme cytochrome c	Ddes_2038	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
517	Alcohol dehydrogenase 1C	ADH1C	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
2112	Toll-like receptor 9	TLR9	0.0017
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
3830	Calreticulin	CALR	0.0016
4943	Cytochrome c6	petJ	0.0015
4954	Soluble cytochrome b558	Not Available	0.0015
4947	Bacterial hemoglobin	vhb	0.0015
4934	Cytochrome c-551	nirM	0.0015
5218	Cytochrome c-551	nirM	0.0015
4905	Cytochrome c2	Not Available	0.0015
4939	Cytochrome c2	cycA	0.0015
4964	Cytochrome c2	cycA	0.0015
4979	Cytochrome c2	cycA	0.0015
6673	Cytochrome c2	cycA	0.0015
4916	Cyanoglobin	glbN	0.0015
4984	Neuroglobin	NGB	0.0015
4925	Cytochrome c-type protein SHP	shp	0.0015
4994	Hemoglobin-like protein HbO	glbO	0.0015
4942	Diheme cytochrome c napB	napB	0.0015
4915	Cytochrome c-550	psbV	0.0015
4959	Cytochrome c-550	psbV	0.0015
5216	Cytochrome c-550	psbV	0.0015
4975	Cytochrome c-556	RPA3973	0.0015
4998	Hemoglobin-like protein yjbI	yjbI	0.0015
4936	Cytochrome c2 iso-2	Not Available	0.0015
4961	Hemophore HasA	hasA	0.0015
5000	HemO	hemO	0.0015
4981	Iron-starvation protein PigA	pigA	0.0015
4910	Cytoglobin	CYGB	0.0015
644	Heme oxygenase 2	HMOX2	0.0015
4982	Heme oxygenase 2	pbsA2	0.0015
4909	CooA protein	cooA	0.0015
3116	Bacterioferritin	bfr	0.0015
4906	Bacterioferritin	bfr	0.0015
4965	Bacterioferritin	bfr	0.0015
4904	Cytochrome c family protein	GSU1996	0.0015
4935	Cytochrome c-554	cycA1	0.0015
4907	Cytochrome c-L	moxG	0.0015
6865	Cytochrome c-L	moxG	0.0015
4971	Nonaheme cytochrome c	hmcA	0.0015
4976	Apocytochrome f	petA	0.0015
6407	Apocytochrome f	petA	0.0015
4937	Cytochrome oxidase subunit II	rcoxA	0.0015
4989	Cytochrome c551 peroxidase	ccp	0.0015
5222	Cytochrome c551 peroxidase	ccpA	0.0015
4764	Cytochrome P450 165C4	CYP165C4	0.0015
4999	Cytochrome P450 165B3	CYP165B3	0.0015
4931	Cytochrome P450 167A1	CYP167A1	0.0015
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0015
4960	Putative cytochrome P450-family protein	SCO7417	0.0015
4972	P450cin	cinA	0.0015
4903	Methyl-accepting chemotaxis protein	Tar4	0.0015
4922	Cytochrome c, putative	SO_4144	0.0015
4993	Hydroxylamine oxidoreductase	hao1	0.0015
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0015
4952	Catalase/peroxidase	katA	0.0015
3093	Catalase HPII	katE	0.0015
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0015
494	Caspase-1	CASP1	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
4386	Hemoglobin-like protein HbN	glbN	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
6034	Hydroxyindole O-methyltransferase	ASMT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6035	Nuclear receptor ROR-beta	RORB	0.0015
174	Sigma 1-type opioid receptor	SIGMAR1	0.0015
6036	Eosinophil peroxidase	EPX	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
6048	Troponin C, skeletal muscle	TNNC2	0.0014
2539	Tubulin alpha-1 chain	TUBA4A	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
2449	Tubulin alpha-3 chain	TUBA1A	0.0014
2232	Interleukin-5	IL5	0.0014
3221	Cytochrome c4	cc4	0.0014
1593	Mucin-2	MUC2	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0013
1268	Neuropeptide S receptor	NPSR1	0.0013
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0013
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0013
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0013
856	Vitamin D3 receptor	VDR	0.0013
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0013
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0013
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0013
251	Alcohol dehydrogenase 1A	ADH1A	0.0013
2077	Caspase-3	CASP3	0.0013
765	Indoleamine 2,3-dioxygenase	IDO1	0.0013
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0013
1262	Corticotropin-lipotropin	POMC	0.0013
5923	Microtubule-associated protein tau	MAPT	0.0013
5924	Microtubule-associated protein 4	MAP4	0.0013
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
820	Glycine receptor subunit alpha-2	GLRA2	0.0012
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0012
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0012
6073	Potassium channel subfamily K member 9	KCNK9	0.0012
6072	Potassium channel subfamily K member 3	KCNK3	0.0012
702	UMP-CMP kinase	CMPK1	0.0012
1852	Microtubule-associated protein 2	MAP2	0.0012
4920	Peroxidase/catalase	katG	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
444	Alcohol dehydrogenase 1B	ADH1B	0.0011
2119	Cytochrome b5	CYB5A	0.0011
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0011
4990	PpcA	ppcA	0.0011
4037	Hypothetical protein	GPX1	0.0011
4297	Hypothetical protein	SP_1951	0.0011
4521	Hypothetical protein	BC_2969	0.0011
4540	Hypothetical protein	TM_1070	0.0011
4555	Hypothetical protein	MT1739	0.0011
4569	Hypothetical protein	mshD	0.0011
4578	Hypothetical protein	PA3270	0.0011
4747	Hypothetical protein	PA3967	0.0011
5177	Hypothetical protein	TM_0096	0.0011
5194	Hypothetical protein	PA1204	0.0011
5240	Hypothetical protein	Rv2991	0.0011
5370	Hypothetical protein	TM_1158	0.0011
5710	Hypothetical protein	Tb927.5.1360	0.0011
4289	Cytochrome P450	TT_P0059	0.0011
6262	Cytochrome P450	staP	0.0011
3570	Cytochrome P450 152A1	cypC	0.0011
4988	Sulfite oxidase, mitochondrial	SUOX	0.0011
4992	Cytochrome c peroxidase	Not Available	0.0011
3375	Acidic cytochrome c3	Not Available	0.0011
2915	Sensor protein fixL	fixL	0.0011
4944	Sensor protein fixL	fixL	0.0011
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0011
4385	Cytochrome c'	Not Available	0.0011
4967	Cytochrome c'	cycA	0.0011
5038	Cytochrome c'	Not Available	0.0011
5223	Cytochrome c'	cycP	0.0011
4813	Heme oxygenase	hmuO	0.0011
5769	Heme oxygenase	Not Available	0.0011
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0011
3913	Glutamic acid decarboxylase	GAD65	0.0011
2230	Catalase	CAT	0.0011
3249	Catalase	katA	0.0011
3625	Catalase	katA	0.0011
4539	Catalase	katA	0.0011
4941	Catalase	katB	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
997	Protein kinase C beta type	PRKCB	0.001
1483	Membrane copper amine oxidase	AOC3	0.001
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.001
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.001
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.001
3670	Soluble cytochrome b562 precursor	cybC	0.001
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.001
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.001
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.001
3411	Cytochrome P450 121	cyp121	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
2617	Nitric oxide synthase oxygenase	nos	0.001
2701	Nitric oxide synthase oxygenase	nos	0.001
3291	Cytochrome c-552	cycA	0.001
4927	Cytochrome c-552	nrfA	0.001
4938	Cytochrome c-552	cycA	0.001
4953	Cytochrome c-552	nrfA	0.001
5217	Cytochrome c-552	cycM	0.001
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.001
3102	Flavohemoprotein	hmp	0.001
4969	Flavohemoprotein	hmp	0.001
6228	Nuclear receptor coactivator 1	NCOA1	0.001
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
735	Alanine aminotransferase 1	GPT	0.0009
3904	Alanine aminotransferase 2	GPT2	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0009
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0009
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0009
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
1184	Interferon beta	IFNB1	0.0008
4608	Putative cytochrome P450	SCO1207	0.0008
4963	Putative cytochrome P450	SCO2884	0.0008
6254	Putative cytochrome P450	SCO6998	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
358	Cystathionine beta-synthase	CBS	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0008
693	Hemoglobin subunit beta	HBB	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0007
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0007
6268	Hydroxyacid oxidase 1	HAO1	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
6824	Tyrosine-protein kinase Lyn	LYN	0.0007
810	Heme oxygenase 1	HMOX1	0.0007
3391	Heme oxygenase 1	pbsA1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
2298	Cytochrome P450-cam	camC	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
798	Osteocalcin	BGLAP	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
5961	Insulin	INS	0.0005
369	Coagulation factor VII	F7	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
6755	Poliovirus receptor	PVR	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00788 - Naproxen

Targets

Enzymes

Transporters

Carriers

Predictions