DT-Web

DB00939 - Meclofenamic acid


Identification
Name Meclofenamic acid
Accession Number DB00939 (APRD01090)
Type small molecule
Description A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 296.149
Groups approved
Monoisotopic Weight 295.016684015
Pharmacology
Indication For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.
Mechanism of action The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease.
Absorption Rapidly absorbed in man following single and multiple oral doses with peak plasma concentrations occurring in 0.5 to 2 hours. The concomitant administration of antacids (aluminum and magnesium hydroxides) does not interfere with absorption of meclofenamic acid. Unlike most NSAIDs, which when administered with food have a decrease in rate but not in extent of absorption, meclofenamic acid is decreased in both. It has been reported that following the administration of meclofenamic acid capsules one-half hour after a meal, the average extent of bioavailability decreased by 26%, the average peak concentration (Cmax) decreased fourfold and the time to Cmax was delayed by 3 hours.
Protein binding Greater than 99% bound to plasma proteins over a wide drug concentration range.
Biotransformation Hepatic. Meclofenamic acid is extensively metabolized to an active metabolite (Metabolite I; 3-hydroxymethyl metabolite of meclofenamic acid) and at least six other less well characterized minor metabolites. Only Metabolite I has been shown in vitro to inhibit cyclooxygenase activity with approximately one fifth the activity of meclofenamic acid.
Route of elimination Other metabolites, whose excretion rates are unknown, account for the remaining 35% to 62% of the dose excreted in the urine. The remainder of the administered dose (approximately 30%) is eliminated in the feces (apparently through biliary excretion). Trace amounts of meclofenamate sodium are excreted in human breast milk.
Toxicity After a massive overdose, CNS stimulation may be manifested by irrational behavior, marked agitation and generalized seizures. Following this phase, renal toxicity (falling urine output, rising creatinine, abnormal urinary cellular elements) may be noted with possible oliguria or anuria and azotemia. A 24 year-old male was anuric for approximately one week after ingesting an overdose of 6 to 7 grams of meclofenamate sodium. Spontaneous diuresis and recovery subsequently occurred.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine Monitor for nephrotoxicity
Eltrombopag Increases levels of Meclofenamic acid via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Methotrexate The NSAID, meclofenamic acid, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Telmisartan Concomitant use of Telmisartan and Meclofenamic acid may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol The NSAID, Meclofenamate, may antagonize the antihypertensive effect of Timolol.
Trandolapril The NSAID, Meclofenamate, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Meclofenamate is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Meclofenamate. Monitor for increased bleeding during concomitant thearpy.
Warfarin The antiplatelet effects of meclofenamic acid may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.
Food Interactions Not Available

Targets


Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions inhibitor
References
  • Perez-Vizcaino F, Lopez-Lopez JG, Santiago R, Cogolludo A, Zaragoza-Arnaez F, Moreno L, Alonso MJ, Salaices M, Tamargo J: Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity. Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L839-48. - Pubmed
  • Shiels IA, Whitehouse MW: Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea. Allerg Immunol (Paris). 2000 Sep;32(7):279-83. - Pubmed
  • Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8. - Pubmed
  • Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ: Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):925-30. - Pubmed
  • Meade EA, Smith WL, DeWitt DL: Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993 Mar 25;268(9):6610-4. - Pubmed
DTHybrid score 0.7261
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ: Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):925-30. - Pubmed
  • Traupe T, Lang M, Goettsch W, Munter K, Morawietz H, Vetter W, Barton M: Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression. J Hypertens. 2002 Nov;20(11):2239-45. - Pubmed
  • Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8. - Pubmed
  • Narsinghani T, Chaturvedi SC: QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):461-8. Epub 2005 Nov 14. - Pubmed
  • Smith WL, Meade EA, DeWitt DL: Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann N Y Acad Sci. 1994 Nov 15;744:50-7. - Pubmed
DTHybrid score 0.6523
Arachidonate 5-lipoxygenase
Name Arachidonate 5-lipoxygenase
Gene Name ALOX5
Pharmacological action yes
Actions inhibitor
References
  • Yu XY, Hubbard W, Spannhake EW: Inhibition of canine tracheal smooth muscle by mediators from cultured bronchial epithelial cells. Am J Physiol. 1992 Feb;262(2 Pt 1):L229-34. - Pubmed
  • Boctor AM, Eickholt M, Pugsley TA: Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. Prostaglandins Leukot Med. 1986 Aug;23(2-3):229-38. - Pubmed
DTHybrid score 0.4078
Potassium voltage-gated channel subfamily KQT member 2
Name Potassium voltage-gated channel subfamily KQT member 2
Gene Name KCNQ2
Pharmacological action unknown
Actions other
References
  • Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol. 2005 Apr;67(4):1053-66. Epub 2004 Dec 14. - Pubmed
DTHybrid score 0.2934
Potassium voltage-gated channel subfamily KQT member 3
Name Potassium voltage-gated channel subfamily KQT member 3
Gene Name KCNQ3
Pharmacological action unknown
Actions other
References
  • Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol. 2005 Apr;67(4):1053-66. Epub 2004 Dec 14. - Pubmed
DTHybrid score 0.3116

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.3775
Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions inhibitor
References
  • Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2075

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.1544
6142 Solute carrier family 22 member 8 SLC22A8 0.1279
587 Serum albumin ALB 0.1137
4512 Cytochrome P450 3A4 CYP3A4 0.1067
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0998
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0998
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0964
1024 Solute carrier family 22 member 11 SLC22A11 0.0957
4924 Cytochrome P450 2C8 CYP2C8 0.0949
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0888
4200 Cytochrome P450 1A2 CYP1A2 0.0835
6016 Cytochrome P450 2C19 CYP2C19 0.0726
1588 Multidrug resistance protein 1 ABCB1 0.0708
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0692
6102 Arylamine N-acetyltransferase 2 NAT2 0.069
2164 Multidrug resistance-associated protein 4 ABCC4 0.0639
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0634
1757 Myeloperoxidase MPO 0.0609
5718 Cytochrome P450 2A6 CYP2A6 0.0583
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0572
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0549
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0527
373 Transthyretin TTR 0.0525
6143 Solute carrier family 22 member 7 SLC22A7 0.0515
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.048
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0475
6182 Cytochrome P450 2J2 CYP2J2 0.0472
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0456
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0453
6013 Cytochrome P450 2E1 CYP2E1 0.0446
6024 Cytochrome P450 1A1 CYP1A1 0.0443
703 NADPH azoreductase azr 0.0427
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.041
862 Multidrug resistance-associated protein 1 ABCC1 0.0408
6106 Cytochrome P450 2C18 CYP2C18 0.0402
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0394
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0393
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0383
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0383
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0383
6030 Cytochrome P450 2B6 CYP2B6 0.0359
3923 Cholinesterase BCHE 0.0352
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0349
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0348
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0339
758 Thyroid hormone receptor alpha THRA 0.0308
4118 Cytochrome P450 3A5 CYP3A5 0.0305
2981 Phospholipase A2, membrane associated PLA2G2A 0.0303
4119 Cytochrome P450 2D6 CYP2D6 0.0295
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0278
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0274
346 Thyroid hormone receptor beta-1 THRB 0.0259
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
738 Monocarboxylate transporter 1 SLC16A1 0.025
6141 Sodium/bile acid cotransporter SLC10A1 0.0247
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0243
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0222
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.022
1507 Cytochrome c CYCS 0.0212
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0208
6167 Organic solute transporter subunit beta OSTB 0.0204
6166 Organic solute transporter subunit alpha OSTA 0.0204
594 Thyroxine-binding globulin SERPINA7 0.0202
3312 Fatty acid-binding protein, brain FABP7 0.0199
118 Organic cation/carnitine transporter 2 SLC22A5 0.0196
1650 Heme carrier protein 1 SLC46A1 0.0196
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0193
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0192
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0187
1159 Interleukin-6 IL6 0.0185
6145 Solute carrier family 22 member 1 SLC22A1 0.0175
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0173
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0169
723 Cytosolic phospholipase A2 PLA2G4A 0.0167
33 Cystine/glutamate transporter SLC7A11 0.0163
6107 Cytochrome P450 3A7 CYP3A7 0.016
6144 Solute carrier family 22 member 2 SLC22A2 0.0155
672 Prostaglandin F2-alpha receptor PTGFR 0.0155
6149 Solute carrier family 22 member 10 SLC22A10 0.0153
633 Penicillin-binding proteins 1A/1B pbpA 0.0149
22 30S ribosomal protein S4 rpsD 0.0148
6714 30S ribosomal protein S4 rpsD 0.0148
592 Carbonic anhydrase 4 CA4 0.0141
140 30S ribosomal protein S9 rpsI 0.014
6719 30S ribosomal protein S9 rpsI 0.014
6725 30S ribosomal protein S9 rpsI 0.014
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
776 Bile salt export pump ABCB11 0.0136
295 Carbonic anhydrase 1 CA1 0.0133
6148 Multidrug resistance-associated protein 7 ABCC10 0.013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0126
850 Vasopressin V1b receptor AVPR1B 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0122
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.012
1654 Interleukin-1 beta IL1B 0.0119
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0119
777 Tumor necrosis factor TNF 0.0117
563 Thyroid peroxidase TPO 0.0116
6136 Multidrug resistance-associated protein 5 ABCC5 0.0116
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
357 Carbonic anhydrase 2 CA2 0.0116
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0112
558 Solute carrier family 12 member 1 SLC12A1 0.0112
4790 Glycosyltransferase GtfA gtfA 0.011
199 Monocarboxylate transporter 8 SLC16A2 0.0109
146 Androgen receptor AR 0.0109
183 Vascular endothelial growth factor A VEGFA 0.0108
185 Vasopressin V1a receptor AVPR1A 0.0107
1618 High affinity nerve growth factor receptor NTRK1 0.0106
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
6043 Putative G-protein coupled receptor 44 GPR44 0.0103
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0102
65 Matrix metalloproteinase-9 Not Available 0.0102
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.01
645 Penicillin-binding protein 1A mrcA 0.01
5805 Penicillin-binding protein 1A ponA 0.01
6185 Penicillin-binding protein 1A mrcA 0.01
6799 Penicillin-binding protein 1A pbpA 0.01
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.01
492 Histamine H1 receptor HRH1 0.01
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0099
1439 Lactotransferrin LTF 0.0098
494 Caspase-1 CASP1 0.0098
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0098
6220 Aryl hydrocarbon receptor AHR 0.0094
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0093
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0093
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
130 Prostacyclin synthase PTGIS 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
489 Monocarboxylate transporter 2 SLC16A7 0.0089
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0088
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
6137 Multidrug resistance-associated protein 6 ABCC6 0.0086
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0086
6085 Fatty acid-binding protein, intestinal FABP2 0.0084
2077 Caspase-3 CASP3 0.0082
3932 Glutathione S-transferase A2 GSTA2 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
1648 Elastin ELN 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0081
6033 High affinity interleukin-8 receptor A CXCR1 0.0077
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
86 SEC14-like protein 4 SEC14L4 0.0075
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0075
6151 Monocarboxylate transporter 10 SLC16A10 0.0075
375 SEC14-like protein 3 SEC14L3 0.0075
4076 Diacylglycerol kinase alpha DGKA 0.0075
3947 Xanthine dehydrogenase/oxidase XDH 0.0075
467 Delta-type opioid receptor OPRD1 0.0074
696 Kappa-type opioid receptor OPRK1 0.0074
3811 Cytochrome P450 19A1 CYP19A1 0.0073
3917 Methylenetetrahydrofolate reductase MTHFR 0.0072
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
1714 Mitogen-activated protein kinase 3 MAPK3 0.007
997 Protein kinase C beta type PRKCB 0.0069
320 5-hydroxytryptamine 1A receptor HTR1A 0.0068
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0068
904 Glutathione S-transferase P GSTP1 0.0067
789 Alpha-1D adrenergic receptor ADRA1D 0.0067
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0066
708 Alpha-tocopherol transfer protein TTPA 0.0065
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0065
1970 Protein kinase C alpha type PRKCA 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
283 SEC14-like protein 2 SEC14L2 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
24 Thymidylate synthase TMP1 0.0064
359 Thymidylate synthase TYMS 0.0064
2626 Thymidylate synthase thyA 0.0064
2729 Thymidylate synthase thyA 0.0064
5352 Thymidylate synthase THYA 0.0064
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0063
905 Glutathione transferase omega-1 GSTO1 0.0063
899 Glutathione S-transferase Mu 3 GSTM3 0.0063
293 Gamma-glutamyl hydrolase GGH 0.0062
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0062
817 DNA topoisomerase 2-alpha TOP2A 0.0061
824 Sodium-dependent serotonin transporter SLC6A4 0.0061
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
540 Sodium-dependent noradrenaline transporter SLC6A2 0.006
810 Heme oxygenase 1 HMOX1 0.006
3391 Heme oxygenase 1 pbsA1 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
556 Alpha-1A adrenergic receptor ADRA1A 0.006
2320 Thymidine kinase, cytosolic TK1 0.0059
70 Type-1 angiotensin II receptor AGTR1 0.0058
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0057
459 Retinoic acid receptor RXR-alpha RXRA 0.0057
6500 Phospholipase A2 PLA2G1B 0.0057
1898 Cytochrome P450 1B1 CYP1B1 0.0057
6218 Pannexin-1 PANX1 0.0057
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0055
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0055
502 5-hydroxytryptamine 2A receptor HTR2A 0.0055
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0054
833 Organic cation/carnitine transporter 1 SLC22A4 0.0054
6131 Carbonic anhydrase 14 CA14 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0054
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
438 Taste receptor type 1 member 2 TAS1R2 0.0051
318 Alpha-2A adrenergic receptor ADRA2A 0.0051
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.005
5818 Folate receptor alpha FOLR1 0.005
6147 Solute carrier family 22 member 3 SLC22A3 0.005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.005
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.005
822 Aldose reductase AKR1B1 0.0049
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
2236 Casein kinase II subunit alpha CSNK2A1 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
3587 Gastrotropin FABP6 0.0048
823 Fibroblast growth factor receptor 2 FGFR2 0.0047
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0047
136 Estrogen receptor ESR1 0.0046
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0046
291 Nitric-oxide synthase, endothelial NOS3 0.0046
7 Nitric oxide synthase, inducible NOS2 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
1656 CYP2B protein CYP2B 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
737 Mineralocorticoid receptor NR3C2 0.0044
3601 Dihydropteroate synthase 1 folP1 0.0044
3807 Dihydropteroate synthase 1 folP1 0.0044
3808 Dihydropteroate synthase 2 folP2 0.0044
663 Solute carrier family 12 member 4 SLC12A4 0.0044
53 Solute carrier family 12 member 5 SLC12A5 0.0044
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0044
5698 Riboflavin synthase alpha chain ribE 0.0043
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0042
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
310 Solute carrier family 12 member 2 SLC12A2 0.0041
811 Translocator protein TSPO 0.004
2021 Thrombomodulin THBD 0.004
614 Progesterone receptor PGR 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0039
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0038
1192 Sulfotransferase 1A1 SULT1A1 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
2853 14 kDa fatty acid-binding protein Not Available 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
1275 Estrogen sulfotransferase SULT1E1 0.0036
244 Angiotensin-converting enzyme ACE 0.0036
3810 Catechol O-methyltransferase COMT 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1050 Bile salt sulfotransferase SULT2A1 0.0034
908 Glutathione S-transferase theta-1 GSTT1 0.0034
871 Glucocorticoid receptor NR3C1 0.0033
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
6042 Prostaglandin reductase 2 PTGR2 0.003
654 Flavin reductase BLVRB 0.0029
6020 Aldehyde oxidase AOX1 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
6103 Arylamine N-acetyltransferase 1 NAT1 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1867 Major prion protein PRNP 0.0028
1792 Tissue-type plasminogen activator PLAT 0.0028
273 Apoptosis regulator Bcl-2 BCL2 0.0027
1025 Aquaporin-1 AQP1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
4943 Cytochrome c6 petJ 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
4934 Cytochrome c-551 nirM 0.0026
5218 Cytochrome c-551 nirM 0.0026
4947 Bacterial hemoglobin vhb 0.0026
4994 Hemoglobin-like protein HbO glbO 0.0026
4916 Cyanoglobin glbN 0.0026
4954 Soluble cytochrome b558 Not Available 0.0026
4942 Diheme cytochrome c napB napB 0.0026
4975 Cytochrome c-556 RPA3973 0.0026
4909 CooA protein cooA 0.0026
4925 Cytochrome c-type protein SHP shp 0.0026
3116 Bacterioferritin bfr 0.0026
4906 Bacterioferritin bfr 0.0026
4965 Bacterioferritin bfr 0.0026
4984 Neuroglobin NGB 0.0026
4998 Hemoglobin-like protein yjbI yjbI 0.0026
4915 Cytochrome c-550 psbV 0.0026
4959 Cytochrome c-550 psbV 0.0026
5216 Cytochrome c-550 psbV 0.0026
4936 Cytochrome c2 iso-2 Not Available 0.0026
4981 Iron-starvation protein PigA pigA 0.0026
4907 Cytochrome c-L moxG 0.0026
6865 Cytochrome c-L moxG 0.0026
4989 Cytochrome c551 peroxidase ccp 0.0026
5222 Cytochrome c551 peroxidase ccpA 0.0026
5000 HemO hemO 0.0026
644 Heme oxygenase 2 HMOX2 0.0026
4982 Heme oxygenase 2 pbsA2 0.0026
4961 Hemophore HasA hasA 0.0026
4764 Cytochrome P450 165C4 CYP165C4 0.0026
4935 Cytochrome c-554 cycA1 0.0026
4999 Cytochrome P450 165B3 CYP165B3 0.0026
4910 Cytoglobin CYGB 0.0026
4904 Cytochrome c family protein GSU1996 0.0026
4976 Apocytochrome f petA 0.0026
6407 Apocytochrome f petA 0.0026
4971 Nonaheme cytochrome c hmcA 0.0026
4937 Cytochrome oxidase subunit II rcoxA 0.0026
4926 Heme-based aerotactic transducer hemAT hemAT 0.0026
4972 P450cin cinA 0.0026
4931 Cytochrome P450 167A1 CYP167A1 0.0026
4960 Putative cytochrome P450-family protein SCO7417 0.0026
4903 Methyl-accepting chemotaxis protein Tar4 0.0026
4952 Catalase/peroxidase katA 0.0026
4922 Cytochrome c, putative SO_4144 0.0026
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0026
4993 Hydroxylamine oxidoreductase hao1 0.0026
3093 Catalase HPII katE 0.0026
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0026
365 Dihydrofolate reductase DHFR 0.0026
2381 Dihydrofolate reductase DFR1 0.0026
2833 Dihydrofolate reductase Not Available 0.0026
2931 Dihydrofolate reductase folA 0.0026
3544 Dihydrofolate reductase folA 0.0026
3682 Dihydrofolate reductase folA 0.0026
6642 Dihydrofolate reductase folA 0.0026
6756 Dihydrofolate reductase dfrA 0.0026
2183 Fatty acid-binding protein, adipocyte FABP4 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
4773 Deoxycytidine kinase DCK 0.0026
6146 High affinity copper uptake protein 1 SLC31A1 0.0026
427 Substance-P receptor TACR1 0.0025
756 Sex hormone-binding globulin SHBG 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0025
4192 DNA topoisomerase 2-beta TOP2B 0.0025
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
3814 Complement C1r subcomponent C1R 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
1629 Transcription factor AP-1 JUN 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
68 Cannabinoid receptor 1 CNR1 0.0023
1313 Lactoylglutathione lyase GLO1 0.0023
4760 Mll3241 protein mll3241 0.0023
2782 Complement C1s subcomponent C1S 0.0022
869 Estrogen receptor beta ESR2 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
3941 Amine oxidase [flavin-containing] A MAOA 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
4604 Liver carboxylesterase 1 CES1 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
1039 Histone deacetylase 9 HDAC9 0.002
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.002
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.002
4920 Peroxidase/catalase katG 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0019
4037 Hypothetical protein GPX1 0.0019
4297 Hypothetical protein SP_1951 0.0019
4521 Hypothetical protein BC_2969 0.0019
4540 Hypothetical protein TM_1070 0.0019
4555 Hypothetical protein MT1739 0.0019
4569 Hypothetical protein mshD 0.0019
4578 Hypothetical protein PA3270 0.0019
4747 Hypothetical protein PA3967 0.0019
5177 Hypothetical protein TM_0096 0.0019
5194 Hypothetical protein PA1204 0.0019
5240 Hypothetical protein Rv2991 0.0019
5370 Hypothetical protein TM_1158 0.0019
5710 Hypothetical protein Tb927.5.1360 0.0019
2119 Cytochrome b5 CYB5A 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4990 PpcA ppcA 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
4289 Cytochrome P450 TT_P0059 0.0019
6262 Cytochrome P450 staP 0.0019
3570 Cytochrome P450 152A1 cypC 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
4992 Cytochrome c peroxidase Not Available 0.0019
4988 Sulfite oxidase, mitochondrial SUOX 0.0019
2915 Sensor protein fixL fixL 0.0019
4944 Sensor protein fixL fixL 0.0019
3375 Acidic cytochrome c3 Not Available 0.0019
4385 Cytochrome c' Not Available 0.0019
4967 Cytochrome c' cycA 0.0019
5038 Cytochrome c' Not Available 0.0019
5223 Cytochrome c' cycP 0.0019
4813 Heme oxygenase hmuO 0.0019
5769 Heme oxygenase Not Available 0.0019
2230 Catalase CAT 0.0019
3249 Catalase katA 0.0019
3625 Catalase katA 0.0019
4539 Catalase katA 0.0019
4941 Catalase katB 0.0019
260 Cytochrome P450 51 ERG11 0.0019
761 Cytochrome P450 51 ERG11 0.0019
3163 Cytochrome P450 51 cyp51 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
891 Dihydropteroate synthase folP 0.0018
5359 Dihydropteroate synthase folP 0.0018
7175 Dihydropteroate synthase sulI 0.0018
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
3670 Soluble cytochrome b562 precursor cybC 0.0017
3411 Cytochrome P450 121 cyp121 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2617 Nitric oxide synthase oxygenase nos 0.0017
2701 Nitric oxide synthase oxygenase nos 0.0017
2207 Rhodopsin RHO 0.0017
3291 Cytochrome c-552 cycA 0.0017
4927 Cytochrome c-552 nrfA 0.0017
4938 Cytochrome c-552 cycA 0.0017
4953 Cytochrome c-552 nrfA 0.0017
5217 Cytochrome c-552 cycM 0.0017
847 Mu-type opioid receptor OPRM1 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
4386 Hemoglobin-like protein HbN glbN 0.0017
3102 Flavohemoprotein hmp 0.0017
4969 Flavohemoprotein hmp 0.0017
518 Peroxidase/catalase T katG 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
1374 Natriuretic peptides B NPPB 0.0015
1827 Gap junction alpha-1 protein GJA1 0.0015
1908 Vascular cell adhesion protein 1 VCAM1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0015
3127 Nitrite reductase nirS 0.0015
3284 Nitrite reductase nirS 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
2972 6-deoxyerythronolide B hydroxylase eryF 0.0015
3221 Cytochrome c4 cc4 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
4608 Putative cytochrome P450 SCO1207 0.0014
4963 Putative cytochrome P450 SCO2884 0.0014
6254 Putative cytochrome P450 SCO6998 0.0014
4217 Telomerase reverse transcriptase TERT 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
528 5-hydroxytryptamine 1E receptor HTR1E 0.0014
358 Cystathionine beta-synthase CBS 0.0014
831 D(2) dopamine receptor DRD2 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
693 Hemoglobin subunit beta HBB 0.0013
819 Penicillin-binding protein 4 dacB 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
6268 Hydroxyacid oxidase 1 HAO1 0.0012
716 5-hydroxytryptamine 7 receptor HTR7 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
702 UMP-CMP kinase CMPK1 0.0012
1864 RET proto-oncogene RET 0.0011
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0011
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0011
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
436 5-hydroxytryptamine 2B receptor HTR2B 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
2298 Cytochrome P450-cam camC 0.0011
725 5-hydroxytryptamine 1D receptor HTR1D 0.001
885 5-hydroxytryptamine 1B receptor HTR1B 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0009
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0009
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0009
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0009
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
921 Glutamate receptor 2 GRIA2 0.0009
228 Beta platelet-derived growth factor receptor PDGFRB 0.0009
1184 Interferon beta IFNB1 0.0008
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
193 Beta-1 adrenergic receptor ADRB1 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
766 Beta-2 adrenergic receptor ADRB2 0.0007
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
124 Histamine H2 receptor HRH2 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
2430 Chondroitinase B cslB 0.0005
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0005
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0005
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0005
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0005
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0005
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0005
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0005
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0005
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
952 Dipeptidyl peptidase 4 DPP4 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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