DT-Web: DB01004

Identification

Name

Ganciclovir

Accession Number

DB01004 (APRD00263, EXPT01540)

Type

small molecule

Description

An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antiviral Agents

Molecular Weight

255.2306

Groups

approved

Monoisotopic Weight

255.096753929

Pharmacology

Indication

For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients.

Mechanism of action

Ganciclovir's antiviral activity inhibits virus replication. This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK). TK catalyzes phosphorylation of ganciclovir to the monophosphate, which is then subsequently converted into the diphosphate by cellular guanylate kinase and into the triphosphate by a number of cellular enzymes. In vitro, ganciclovir triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, ganciclovir triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed.

Absorption

Poorly absorbed systemically following oral administration. Bioavailability under fasting conditions is approximately 5%, and when administered with food, 6 to 9% (about 30% with a fatty meal).

Protein binding

1 to 2%

Biotransformation

Little to no metabolism, about 90% of plasma ganciclovir is eliminated unchanged in the urine.

Route of elimination

Renal excretion of unchanged drug by glomerular filtration and active tubular secretion is the major route of elimination of ganciclovir.

Toxicity

Oral, mouse LD₅₀: > 2g/kg. Intravenous, dog LD₅₀: > 150mg/kg. Symptoms of overdose include irreversible pancytopenia, worsening GI symptoms, and acute renal failure. Suspected cancer agent.

Affected organisms

Human Herpes Virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abacavir	The adverse/toxic effects of reverse transcriptase inhibitors (nucleoside), such as Abacavir, may be enhanced by Ganciclovir. There is a risk of hematologic toxicity. Diligent monitoring during concomitant therapy is required.
Didanosine	The antiviral agent, ganciclovir, may increase the effect and toxicity of didanosine.
Probenecid	Probenecid increases the effect and toxicity of ganciclovir/valganciclovir
Zidovudine	Increased risk of hematologic toxicity. Concomitant therapy should be avoided.

Food Interactions

Take with food, food increases bioavailability.

DNA polymerase
Name	DNA polymerase
Gene Name	UL30
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Boivin G, Goyette N, Gilbert C, Covington E: Analysis of cytomegalovirus DNA polymerase (UL54) mutations in solid organ transplant patients receiving valganciclovir or ganciclovir prophylaxis. J Med Virol. 2005 Nov;77(3):425-9. - Pubmed Wang JT, Yang PW, Lee CP, Han CH, Tsai CH, Chen MR: Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles. J Gen Virol. 2005 Dec;86(Pt 12):3215-25. - Pubmed Shi R, Azzi A, Gilbert C, Boivin G, Lin SX: Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance. Proteins. 2006 Aug 1;64(2):301-7. - Pubmed
DTHybrid score	0.4464
DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	incorporation into and destabilization
References	Martin M, Azzi A, Lin SX, Boivin G: Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity. Antivir Ther. 2010;15(4):579-86. - Pubmed Boivin G, Goyette N, Gilbert C, Covington E: Analysis of cytomegalovirus DNA polymerase (UL54) mutations in solid organ transplant patients receiving valganciclovir or ganciclovir prophylaxis. J Med Virol. 2005 Nov;77(3):425-9. - Pubmed Marfori JE, Exner MM, Marousek GI, Chou S, Drew WL: Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients. J Clin Virol. 2007 Feb;38(2):120-5. Epub 2006 Dec 8. - Pubmed Potena L, Holweg CT, Chin C, Luikart H, Weisshaar D, Narasimhan B, Fearon WF, Lewis DB, Cooke JP, Mocarski ES, Valantine HA: Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. Transplantation. 2006 Aug 15;82(3):398-405. - Pubmed
DTHybrid score	Not Available
Thymidine kinase
Name	Thymidine kinase
Gene Name	TK
Pharmacological action	yes
Actions	inducer
References	Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR: Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins. 1998 Aug 15;32(3):350-61. - Pubmed
DTHybrid score	0.0366

Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score	0.2696
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score	0.448
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score	0.3585
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score	0.2286

Id	Partner name	Gene Name	Score
379	DNA polymerase	UL54	0.4464
697	DNA polymerase	ORF28	0.4464
2482	DNA polymerase	43	0.4464
4104	DNA polymerase	BALF5	0.4464
1024	Solute carrier family 22 member 11	SLC22A11	0.1531
4512	Cytochrome P450 3A4	CYP3A4	0.0925
6144	Solute carrier family 22 member 2	SLC22A2	0.0908
587	Serum albumin	ALB	0.0779
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0753
1588	Multidrug resistance protein 1	ABCB1	0.0743
118	Organic cation/carnitine transporter 2	SLC22A5	0.0673
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0641
738	Monocarboxylate transporter 1	SLC16A1	0.0627
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0615
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0609
4757	Cytochrome P450 2C9	CYP2C9	0.0602
6020	Aldehyde oxidase	AOX1	0.0579
2251	Thymidylate kinase	tmk	0.0567
2254	Thymidylate kinase	DTYMK	0.0567
3522	Thymidylate kinase	tmk	0.0567
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0529
2164	Multidrug resistance-associated protein 4	ABCC4	0.0508
4200	Cytochrome P450 1A2	CYP1A2	0.0504
290	Prostaglandin G/H synthase 2	PTGS2	0.0482
20	Prostaglandin G/H synthase 1	PTGS1	0.0474
6016	Cytochrome P450 2C19	CYP2C19	0.0454
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0453
833	Organic cation/carnitine transporter 1	SLC22A4	0.0433
4119	Cytochrome P450 2D6	CYP2D6	0.0424
6147	Solute carrier family 22 member 3	SLC22A3	0.0421
4924	Cytochrome P450 2C8	CYP2C8	0.0395
4118	Cytochrome P450 3A5	CYP3A5	0.0382
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.038
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0376
862	Multidrug resistance-associated protein 1	ABCC1	0.037
509	Thymidine kinase	TK	0.0366
570	Thymidine kinase	TK	0.0366
3430	Thymidine kinase	tdk	0.0366
3518	Thymidine kinase	TK	0.0366
5301	Thymidine kinase	tdk	0.0366
5771	Thymidine kinase	ORF36	0.0366
7009	Thymidine kinase	ORF36	0.0366
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0328
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0327
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.032
6107	Cytochrome P450 3A7	CYP3A7	0.0298
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0297
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0281
22	30S ribosomal protein S4	rpsD	0.0278
6714	30S ribosomal protein S4	rpsD	0.0278
776	Bile salt export pump	ABCB11	0.0277
6136	Multidrug resistance-associated protein 5	ABCC5	0.0275
140	30S ribosomal protein S9	rpsI	0.0262
6719	30S ribosomal protein S9	rpsI	0.0262
6725	30S ribosomal protein S9	rpsI	0.0262
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0247
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0241
6141	Sodium/bile acid cotransporter	SLC10A1	0.024
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0238
633	Penicillin-binding proteins 1A/1B	pbpA	0.0219
645	Penicillin-binding protein 1A	mrcA	0.021
5805	Penicillin-binding protein 1A	ponA	0.021
6185	Penicillin-binding protein 1A	mrcA	0.021
6799	Penicillin-binding protein 1A	pbpA	0.021
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0208
6171	Solute carrier family 28 member 3	SLC28A3	0.0205
6024	Cytochrome P450 1A1	CYP1A1	0.0202
2016	Dipeptidase 1	DPEP1	0.0197
543	Penicillin-binding protein 1B	mrcB	0.0188
6186	Penicillin-binding protein 1B	ponB	0.0188
6822	Penicillin-binding protein 1b	pbp1b	0.0188
6844	Penicillin-binding protein 1b	pbp1b	0.0188
672	Prostaglandin F2-alpha receptor	PTGFR	0.0188
3947	Xanthine dehydrogenase/oxidase	XDH	0.0188
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0186
5353	Glutamate decarboxylase alpha	gadA	0.0178
2257	Uridine phosphorylase	udp	0.0177
5132	Uridine phosphorylase	udp	0.0177
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0175
24	Thymidylate synthase	TMP1	0.0175
359	Thymidylate synthase	TYMS	0.0175
2626	Thymidylate synthase	thyA	0.0175
2729	Thymidylate synthase	thyA	0.0175
5352	Thymidylate synthase	THYA	0.0175
4275	PCZA361.16	Not Available	0.0175
4276	DNA polymerase III subunit epsilon	dnaQ	0.0174
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0173
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0172
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0168
124	Histamine H2 receptor	HRH2	0.0159
6148	Multidrug resistance-associated protein 7	ABCC10	0.0158
1353	DNA topoisomerase 1	TOP1	0.0157
3552	DNA topoisomerase 1	topA	0.0157
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0156
6013	Cytochrome P450 2E1	CYP2E1	0.0154
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
5626	Nucleoside diphosphate kinase B	NME2	0.0144
6149	Solute carrier family 22 member 10	SLC22A10	0.0142
592	Carbonic anhydrase 4	CA4	0.0141
404	DNA gyrase subunit A	gyrA	0.0139
6224	DNA gyrase subunit A	gyrA	0.0139
6030	Cytochrome P450 2B6	CYP2B6	0.0136
1867	Major prion protein	PRNP	0.0136
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0136
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0134
295	Carbonic anhydrase 1	CA1	0.0133
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0133
357	Carbonic anhydrase 2	CA2	0.0131
4773	Deoxycytidine kinase	DCK	0.0129
831	D(2) dopamine receptor	DRD2	0.0128
558	Solute carrier family 12 member 1	SLC12A1	0.0128
3685	Catabolite gene activator	crp	0.0127
4655	Adenylate cyclase	cyaC	0.0127
4759	Adenylate cyclase	cyaB2	0.0127
5294	Nucleoside diphosphate kinase A	NME1	0.0127
3639	Thymidine phosphorylase	deoA	0.0127
3936	Thymidine phosphorylase	TYMP	0.0127
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0124
5718	Cytochrome P450 2A6	CYP2A6	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
438	Taste receptor type 1 member 2	TAS1R2	0.0122
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
6207	30S ribosomal protein S14	rpsN	0.0117
6209	30S ribosomal protein S19	rpsS	0.0117
6712	30S ribosomal protein S19	rpsS	0.0117
6726	30S ribosomal protein S19	rpsS	0.0117
23	D(1A) dopamine receptor	DRD1	0.0116
6167	Organic solute transporter subunit beta	OSTB	0.0114
6166	Organic solute transporter subunit alpha	OSTA	0.0114
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0111
3686	Acyl-CoA thioesterase I precursor	tesA	0.0111
2249	Aspartate aminotransferase	aspC	0.011
2671	Aspartate aminotransferase	aspC	0.011
5490	Aspartate aminotransferase	Not Available	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
4760	Mll3241 protein	mll3241	0.0109
556	Alpha-1A adrenergic receptor	ADRA1A	0.0108
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0107
6106	Cytochrome P450 2C18	CYP2C18	0.0106
115	Penicillin-binding protein 2	mrdA	0.0104
6069	Penicillin-binding protein 2	mrdA	0.0104
6118	Penicillin-binding protein 2	penA	0.0104
6187	Penicillin-binding protein 2	pbpA	0.0104
6686	Penicillin-binding protein 2	pbp2	0.0104
6939	Penicillin-binding protein 2	mrdA	0.0104
7163	Penicillin-binding protein 2	pbpA	0.0104
244	Angiotensin-converting enzyme	ACE	0.0103
1898	Cytochrome P450 1B1	CYP1B1	0.0101
6033	High affinity interleukin-8 receptor A	CXCR1	0.0101
527	Prostacyclin receptor	PTGIR	0.01
756	Sex hormone-binding globulin	SHBG	0.01
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.01
2320	Thymidine kinase, cytosolic	TK1	0.01
492	Histamine H1 receptor	HRH1	0.0099
887	DNA gyrase subunit B	gyrB	0.0099
4150	DNA gyrase subunit B	gyrB	0.0099
6225	DNA gyrase subunit B	gyrB	0.0099
6031	Cytochrome P450 3A43	CYP3A43	0.0098
1	Peptidoglycan synthetase ftsI	ftsI	0.0096
4155	Peptidoglycan synthetase ftsI	ftsI	0.0096
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0095
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
275	Arachidonate 5-lipoxygenase	ALOX5	0.0092
867	Penicillin-binding protein 3	pbpC	0.0092
6119	Penicillin-binding protein 3	pbp3	0.0092
7154	Penicillin-binding protein 3	pbp3	0.0092
7157	Penicillin-binding protein 3	LMHCC_2184	0.0092
7162	Penicillin-binding protein 3	pbpB	0.0092
7172	Penicillin-binding protein 3	pbp3	0.0092
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0092
632	Alpha-1B adrenergic receptor	ADRA1B	0.0092
1654	Interleukin-1 beta	IL1B	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0088
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0088
3811	Cytochrome P450 19A1	CYP19A1	0.0087
4122	Histone deacetylase 2	HDAC2	0.0087
474	Acetylcholinesterase	ACHE	0.0086
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0084
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0084
53	Solute carrier family 12 member 5	SLC12A5	0.0084
663	Solute carrier family 12 member 4	SLC12A4	0.0084
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0083
723	Cytosolic phospholipase A2	PLA2G4A	0.0083
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0083
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0083
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0082
6126	Carbonic anhydrase 7	CA7	0.0082
766	Beta-2 adrenergic receptor	ADRB2	0.0081
65	Matrix metalloproteinase-9	Not Available	0.0081
4604	Liver carboxylesterase 1	CES1	0.0081
378	Alpha-2C adrenergic receptor	ADRA2C	0.008
16	Adenosine A1 receptor	ADORA1	0.008
332	Beta-lactamase	blaZ	0.0079
2478	Beta-lactamase	ampC	0.0079
2613	Beta-lactamase	ampC	0.0079
2635	Beta-lactamase	ampC	0.0079
2700	Beta-lactamase	penP	0.0079
5445	Beta-lactamase	blaB	0.0079
6019	Beta-lactamase	SHV-7	0.0079
6701	Beta-lactamase	cphA	0.0079
1178	Adenosine A2a receptor	ADORA2A	0.0078
310	Solute carrier family 12 member 2	SLC12A2	0.0078
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
2472	Voltage-gated potassium channel	kcsA	0.0075
6366	Voltage-gated potassium channel	kcsA	0.0075
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0074
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0074
373	Transthyretin	TTR	0.0073
494	Caspase-1	CASP1	0.0073
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
183	Vascular endothelial growth factor A	VEGFA	0.0072
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0071
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.007
1507	Cytochrome c	CYCS	0.007
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0069
629	Alpha-2B adrenergic receptor	ADRA2B	0.0069
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0068
4217	Telomerase reverse transcriptase	TERT	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
146	Androgen receptor	AR	0.0067
6014	Cytochrome P450 2A13	CYP2A13	0.0066
3760	Penicillin-binding protein 5 precursor	dacA	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
193	Beta-1 adrenergic receptor	ADRB1	0.0065
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0065
1757	Myeloperoxidase	MPO	0.0065
477	DNA topoisomerase 4 subunit A	parC	0.0064
886	DNA topoisomerase 4 subunit A	parC	0.0064
6226	DNA topoisomerase 4 subunit A	parC	0.0064
277	Purine nucleoside phosphorylase	PNP	0.0064
2870	Purine nucleoside phosphorylase	punA	0.0064
2945	Purine nucleoside phosphorylase	punA	0.0064
4659	Purine nucleoside phosphorylase	TM_1596	0.0064
4825	Purine nucleoside phosphorylase	TTHA1435	0.0064
3923	Cholinesterase	BCHE	0.0063
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0063
6137	Multidrug resistance-associated protein 6	ABCC6	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
3941	Amine oxidase [flavin-containing] A	MAOA	0.0063
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0062
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0062
318	Alpha-2A adrenergic receptor	ADRA2A	0.0061
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0061
2077	Caspase-3	CASP3	0.0061
1405	Thiopurine S-methyltransferase	TPMT	0.0061
130	Prostacyclin synthase	PTGIS	0.0061
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.006
136	Estrogen receptor	ESR1	0.006
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0059
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0059
819	Penicillin-binding protein 4	dacB	0.0059
6218	Pannexin-1	PANX1	0.0059
6043	Putative G-protein coupled receptor 44	GPR44	0.0057
5126	Arginase	rocF	0.0057
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0056
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0056
3587	Gastrotropin	FABP6	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0054
408	Riboflavin kinase	RFK	0.0054
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0054
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0054
293	Gamma-glutamyl hydrolase	GGH	0.0054
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0053
818	50S ribosomal protein L10	rplJ	0.0053
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0052
740	Argininosuccinate synthase	ASS1	0.0052
865	Argininosuccinate synthase	ASS1	0.0052
2680	Argininosuccinate synthase	argG	0.0052
3194	Argininosuccinate synthase	argG	0.0052
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0052
4238	50S ribosomal protein L4	rplD	0.0052
5578	50S ribosomal protein L4	rplD	0.0052
6173	50S ribosomal protein L4	rplD	0.0052
6219	50S ribosomal protein L4	rplD	0.0052
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.005
1198	Serum paraoxonase/arylesterase 1	PON1	0.005
6223	Penicillin-binding protein 1C	pbpC	0.005
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0048
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0048
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0048
789	Alpha-1D adrenergic receptor	ADRA1D	0.0048
1650	Heme carrier protein 1	SLC46A1	0.0047
4237	50S ribosomal protein L22	rplV	0.0047
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0047
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0047
731	HIV-1 protease	HIV-1 protease	0.0047
273	Apoptosis regulator Bcl-2	BCL2	0.0046
624	Guanidinoacetate N-methyltransferase	GAMT	0.0046
1039	Histone deacetylase 9	HDAC9	0.0045
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0045
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0045
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0044
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0043
817	DNA topoisomerase 2-alpha	TOP2A	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0042
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0042
5682	Ribonuclease pancreatic	RNASE1	0.0042
6070	Nischarin	NISCH	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
5818	Folate receptor alpha	FOLR1	0.004
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.004
702	UMP-CMP kinase	CMPK1	0.004
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.004
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.004
6042	Prostaglandin reductase 2	PTGR2	0.004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.004
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0039
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0039
3939	Amine oxidase [flavin-containing] B	MAOB	0.0039
694	Matrix protein 2	M	0.0039
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0039
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0039
5482	Sialidase-2	NEU2	0.0039
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0038
869	Estrogen receptor beta	ESR2	0.0037
489	Monocarboxylate transporter 2	SLC16A7	0.0037
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0037
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0037
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0037
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0037
6131	Carbonic anhydrase 14	CA14	0.0035
1830	5'-nucleotidase	NT5E	0.0035
6085	Fatty acid-binding protein, intestinal	FABP2	0.0034
824	Sodium-dependent serotonin transporter	SLC6A4	0.0034
125	DNA polymerase beta	POLB	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
3932	Glutathione S-transferase A2	GSTA2	0.0034
4226	Uridine phosphorylase 2	UPP2	0.0034
2300	Lysozyme	E	0.0033
3633	Lysozyme	R	0.0033
5597	Lysozyme	17	0.0033
6122	Carbonic anhydrase 3	CA3	0.0033
3007	Carbonic anhydrase 12	CA12	0.0033
4205	Carbonic anhydrase 9	CA9	0.0033
5924	Microtubule-associated protein 4	MAP4	0.0032
5923	Microtubule-associated protein tau	MAPT	0.0032
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0032
828	Phenylalanine-4-hydroxylase	PAH	0.0032
3109	Phenylalanine-4-hydroxylase	phhA	0.0032
758	Thyroid hormone receptor alpha	THRA	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0031
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0031
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0031
465	Calmodulin	CALM1	0.0031
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0031
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0031
1313	Lactoylglutathione lyase	GLO1	0.003
4225	Uridine phosphorylase 1	UPP1	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
1852	Microtubule-associated protein 2	MAP2	0.003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.003
654	Flavin reductase	BLVRB	0.0029
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
2391	Ferrochelatase	hemH	0.0029
6502	Ferrochelatase	DKFZp686P18130	0.0029
1591	Ferrochelatase, mitochondrial	FECH	0.0029
952	Dipeptidyl peptidase 4	DPP4	0.0029
413	Amidophosphoribosyltransferase	PPAT	0.0029
2515	Amidophosphoribosyltransferase	purF	0.0029
3714	Amidophosphoribosyltransferase	purF	0.0029
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0029
713	Sodium-dependent dopamine transporter	SLC6A3	0.0029
4252	Penicillin-binding protein 5	dacA	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
380	Cytochrome P450 17A1	CYP17A1	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
1341	Histamine H3 receptor	HRH3	0.0028
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0028
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0027
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
2021	Thrombomodulin	THBD	0.0027
1025	Aquaporin-1	AQP1	0.0027
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
6111	DNA polymerase epsilon subunit 4	POLE4	0.0027
6112	DNA polymerase epsilon subunit 3	POLE3	0.0027
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0026
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0026
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0026
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0026
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0026
6110	DNA polymerase epsilon subunit 2	POLE2	0.0026
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0026
164	Histamine H4 receptor	HRH4	0.0026
751	Potassium channel subfamily K member 6	KCNK6	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0026
3810	Catechol O-methyltransferase	COMT	0.0026
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0026
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0026
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0026
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0025
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0025
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0025
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0025
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0025
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0025
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0025
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0025
6559	Cytochrome c oxidase subunit 2	ctaC	0.0025
6669	Cytochrome c oxidase subunit 2	ctaC	0.0025
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0025
6558	Cytochrome c oxidase subunit 1	ctaD	0.0025
33	Cystine/glutamate transporter	SLC7A11	0.0025
29	Tubulin beta-1 chain	TUBB1	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
163	D(1B) dopamine receptor	DRD5	0.0024
172	Potassium channel subfamily K member 1	KCNK1	0.0024
2540	Choloylglycine hydrolase	cbh	0.0023
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0023
432	D(4) dopamine receptor	DRD4	0.0023
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0022
638	D(3) dopamine receptor	DRD3	0.0022
6501	Fatty acid-binding protein, liver	FABP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
1196	Complement decay-accelerating factor	CD55	0.0021
6168	Solute carrier family 22 member 16	SLC22A16	0.0021
365	Dihydrofolate reductase	DHFR	0.0021
2381	Dihydrofolate reductase	DFR1	0.0021
2833	Dihydrofolate reductase	Not Available	0.0021
2931	Dihydrofolate reductase	folA	0.0021
3544	Dihydrofolate reductase	folA	0.0021
3682	Dihydrofolate reductase	folA	0.0021
6642	Dihydrofolate reductase	folA	0.0021
6756	Dihydrofolate reductase	dfrA	0.0021
6151	Monocarboxylate transporter 10	SLC16A10	0.0021
4203	Histamine N-methyltransferase	HNMT	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0021
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
976	Platelet glycoprotein IX	GP9	0.0021
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.002
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.002
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.002
504	Mast/stem cell growth factor receptor	KIT	0.002
603	DNA polymerase alpha catalytic subunit	POLA1	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
3809	Estrogen-related receptor gamma	ESRRG	0.002
1714	Mitogen-activated protein kinase 3	MAPK3	0.0019
6432	Transporter	snf	0.0019
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0019
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0019
467	Delta-type opioid receptor	OPRD1	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
1792	Tissue-type plasminogen activator	PLAT	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
696	Kappa-type opioid receptor	OPRK1	0.0019
3957	Adenosine deaminase	ADA	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
5287	Signaling protein	Not Available	0.0018
2874	Nitrogenase iron protein 1	nifH1	0.0018
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0018
5292	Putative partitioning protein	TT_C1605	0.0018
5293	Shikimate kinase 2	aroL	0.0018
5288	Shikimate kinase	aroK	0.0018
5304	UPF0166 protein TM_0021	TM_0021	0.0018
5266	Activator of	hgdC	0.0018
3199	Phosphopantetheine adenylyltransferase	coaD	0.0018
3543	Phosphopantetheine adenylyltransferase	coaD	0.0018
3567	Phosphopantetheine adenylyltransferase	coaD	0.0018
5289	Phosphopantetheine adenylyltransferase	coaD	0.0018
4346	Polynucleotide kinase	pseT	0.0018
5283	D-alanine--D-alanine ligase B	ddlB	0.0018
5291	Glycogen synthase 1	glgA1	0.0018
5281	Plasmid segregation protein parM	parM	0.0018
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0018
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0018
5299	D-alanine--D-alanine ligase	ddl	0.0018
6598	D-alanine--D-alanine ligase	ddl	0.0018
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0018
5259	Transcriptional regulator	ntrC1	0.0018
6699	Transcriptional regulator	Cgl2612	0.0018
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0018
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0018
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0018
5264	DNA replication protein	REP	0.0018
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0018
5315	Chaperone protein htpG	htpG	0.0018
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0018
5284	Large T antigen	Not Available	0.0018
5308	Preprotein translocase secA 1 subunit	secA1	0.0018
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0018
5285	Kinesin heavy chain	KIF5B	0.0018
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0018
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0018
5277	Preprotein translocase subunit secA	secA	0.0018
6500	Phospholipase A2	PLA2G1B	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
847	Mu-type opioid receptor	OPRM1	0.0018
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0018
284	DNA-directed RNA polymerase beta chain	rpoB	0.0017
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
3924	Phospholipase D1	PLD1	0.0016
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0016
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
517	Alcohol dehydrogenase 1C	ADH1C	0.0016
459	Retinoic acid receptor RXR-alpha	RXRA	0.0016
4106	Guanylate kinase	GUK1	0.0016
4516	Guanylate kinase	gmk	0.0016
4837	Cag-alfa	cag-alfa	0.0016
5646	Galactokinase	GALK1	0.0016
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0016
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0016
5302	TrwB	trwB	0.0016
4774	NTPase P4	Not Available	0.0016
5265	FtsH	ftsH	0.0016
4839	DNA polymerase III subunit tau	dnaX	0.0016
4838	PMS1 protein homolog 2	PMS2	0.0016
6165	Copper-transporting ATPase 1	ATP7A	0.0016
6163	Copper-transporting ATPase 2	ATP7B	0.0016
2270	Dephospho-CoA kinase	coaE	0.0016
5189	Trimethylamine dehydrogenase	tmd	0.0016
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0016
2284	Adenylate kinase	adk	0.0016
2296	Adenylate kinase	adk	0.0016
2311	Adenylate kinase	adk	0.0016
2312	Adenylate kinase	Not Available	0.0016
3470	Hypothetical protein MG245 homolog	MPN_348	0.0015
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0015
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
3175	Glutamate--cysteine ligase	gshA	0.0015
3426	Glutamine synthetase	glnA	0.0015
3987	Glutamine synthetase	GLUL	0.0015
1864	RET proto-oncogene	RET	0.0015
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0015
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0015
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0015
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0015
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0015
6146	High affinity copper uptake protein 1	SLC31A1	0.0015
1517	Beta-3 adrenergic receptor	ADRB3	0.0015
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0014
2683	Mono-ADP-ribosyltransferase C3	C3	0.0014
2390	Nonsecretory ribonuclease	RNASE2	0.0014
153	Dopamine beta-hydroxylase	DBH	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
5312	Kinesin-like protein KIF1A	KIF1A	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
908	Glutathione S-transferase theta-1	GSTT1	0.0014
2922	Glycerol kinase	glpK	0.0014
5271	Focal adhesion kinase 1	PTK2	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
340	Apoptotic protease-activating factor 1	APAF1	0.0014
468	Cytochrome P450 4A11	CYP4A11	0.0014
822	Aldose reductase	AKR1B1	0.0014
2615	Chemotaxis protein cheA	cheA	0.0013
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0013
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
2282	Protein recA	recA	0.0013
2315	Protein recA	recA	0.0013
2332	Protein recA	recA	0.0013
5263	Protein recA	recA	0.0013
2371	Pantothenate kinase	coaA	0.0013
1881	Hexokinase-1	HK1	0.0013
3669	Ribokinase	rbsK	0.0013
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0013
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0013
2892	Acetylglutamate kinase	argB	0.0013
3550	Acetylglutamate kinase	argB	0.0013
5300	Antigen peptide transporter 1	TAP1	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0013
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0013
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0013
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
896	Glutathione S-transferase Mu 1	GSTM1	0.0013
2727	S-adenosylmethionine synthetase	metK	0.0013
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0013
1618	High affinity nerve growth factor receptor	NTRK1	0.0013
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0013
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0012
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0012
2697	Uridine-cytidine kinase 2	UCK2	0.0012
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0012
788	Creatine kinase M-type	CKM	0.0012
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0012
2334	Dethiobiotin synthetase	bioD	0.0012
6555	Dethiobiotin synthetase	bioD	0.0012
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0012
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0012
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0012
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0012
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0012
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0011
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0011
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0011
904	Glutathione S-transferase P	GSTP1	0.0011
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0011
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0011
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0011
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0011
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
48	Pyridoxal kinase	PDXK	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0011
6395	Myosin-14	MYH14	0.0011
2091	Endoplasmin	HSP90B1	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0011
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
1422	Serine/threonine-protein kinase 6	AURKA	0.0011
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0011
1192	Sulfotransferase 1A1	SULT1A1	0.001
70	Type-1 angiotensin II receptor	AGTR1	0.001
3379	Kinesin-like protein KIF11	KIF11	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.001
737	Mineralocorticoid receptor	NR3C2	0.001
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.001
997	Protein kinase C beta type	PRKCB	0.001
207	Glutathione synthetase	GSS	0.001
5269	Glutathione synthetase	gshB	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
3822	Actin, alpha skeletal muscle	ACTA1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
1275	Estrogen sulfotransferase	SULT1E1	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.001
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.001
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
1050	Bile salt sulfotransferase	SULT2A1	0.001
6102	Arylamine N-acetyltransferase 2	NAT2	0.0009
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0009
614	Progesterone receptor	PGR	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0009
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0009
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0009
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0008
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0008
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0008
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0008
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0007
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0007
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0007
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0007
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0007
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0007
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0007
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0007
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0007
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0007
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0007
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0007
2236	Casein kinase II subunit alpha	CSNK2A1	0.0007
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0007
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0007
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0007
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0007
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0007
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0007
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0007
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0007
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0006
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0006
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0006
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0006
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0006
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0006
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0006
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0006
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0005

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01004 - Ganciclovir

Targets

Transporters

Predictions