DT-Web

DB00900 - Didanosine


Identification
Name Didanosine
Accession Number DB00900 (APRD00240, DB02392)
Type small molecule
Description A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 236.2273
Groups approved
Monoisotopic Weight 236.09094027
Pharmacology
Indication For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
Mechanism of action Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moiety, dideoxyadenosine triphosphate (ddATP), which inhibits the HIV reverse transcriptase enzyme competitively by competing with natural dATP. It also acts as a chain terminator by its incorporation into viral DNA as the lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.
Absorption Rapidly absorbed (bioavailability 30-40%) with peak plasma concentrations appearing within 0.5 and 1.5 hrs.
Protein binding Low (<5%)
Biotransformation Rapidly metabolized intracellularly to its active moiety, 2,3-dideoxyadenosine-5-triphosphate (ddA-TP). It is then further metabolized hepatically to yield hypoxanthine, xanthine, and uric acid.
Route of elimination Based on data from in vitro and animal studies, it is presumed that the metabolism of didanosine in man occurs by the same pathways responsible for the elimination of endogenous purines. Purines are eliminated by the kidneys.
Toxicity Side effects include pancreatitis, peripheral neuropathy, diarrhea, hyperuricemia and hepatic dysfunction
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Ganciclovir The antiviral agent, ganciclovir, may increase the effect and toxicity of didanosine.
Tenofovir Tenofovir may decrease the therapeutic effects and increase the adverse effects of Didanosine. Monitor for changes in virologic response and Didanosine toxicity during concomitant therapy.
Tipranavir Tipranavir may decrease the concentration of Didanosine.
Tobramycin Increased risk of nephrotoxicity
Trovafloxacin Didanosine may decrease the absorption of orally administered Trovafloxacin. The Didanosine formulation contains magnesium and aluminum ions that intefere with Trovafloxacin absorption. Administer Trovafloxacin 2 hours before or 6 hours after the Didanosine dose to minimize the interaction. This interaction is not observed with enteric coated Didanosine.
Valganciclovir The adverse/toxic effects of Didanosine, a reverse transcriptase inhibitor (nucleoside), may be enhanced by Valganciclovir. There is a significant risk of hematologic toxicity. Concomitant therapy should be avoided.
Voriconazole Didanosine may interfere with the absorption of orally administered voriconazole. Enteric coated didanosine does not exert this effect. Didanosine buffered formulations should be administered at least 2 hours from oral voriconazole administration.
Zalcitabine Additive toxicities (peripheral neuropathy)
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Avoid alcohol.

Targets


Reverse transcriptase
Name Reverse transcriptase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Barry M, Gibbons S, Back D, Mulcahy F: Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. - Pubmed
  • Frankel FA, Marchand B, Turner D, Gotte M, Wainberg MA: Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 2005 Jul;49(7):2657-64. - Pubmed
  • Idzik KR, Cywinski PJ, Cranfield CG, Mohr GJ, Beckert R: Molecular Recognition of the Antiretroviral Drug Abacavir: Towards the Development of a Novel Carbazole-Based Fluorosensor. J Fluoresc. 2011 Jan 11. - Pubmed
  • Hazen R, Harvey R, Ferris R, Craig C, Yates P, Griffin P, Miller J, Kaldor I, Ray J, Samano V, Furfine E, Spaltenstein A, Hale M, Tung R, St Clair M, Hanlon M, Boone L: In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV. Antimicrob Agents Chemother. 2007 Sep;51(9):3147-54. Epub 2007 Jul 9. - Pubmed
DTHybrid score Not Available
Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name PNP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.49

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate
References
  • Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. - Pubmed
DTHybrid score 0.2701
Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions Not Available
References
  • Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD: Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol. 2001 Apr-Jun;18(2):161-7. - Pubmed
DTHybrid score 0.291
Equilibrative nucleoside transporter 2
Name Equilibrative nucleoside transporter 2
Gene Name Not Available
Actions Not Available
References
  • Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD: Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol. 2001 Apr-Jun;18(2):161-7. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2870 Purine nucleoside phosphorylase punA 1.49
2945 Purine nucleoside phosphorylase punA 1.49
4659 Purine nucleoside phosphorylase TM_1596 1.49
4825 Purine nucleoside phosphorylase TTHA1435 1.49
4773 Deoxycytidine kinase DCK 0.0878
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.085
5421 Uridine phosphorylase, putative PFE0660c 0.0777
6171 Solute carrier family 28 member 3 SLC28A3 0.0754
6142 Solute carrier family 22 member 8 SLC22A8 0.0634
2257 Uridine phosphorylase udp 0.0489
5132 Uridine phosphorylase udp 0.0489
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0467
1024 Solute carrier family 22 member 11 SLC22A11 0.0421
6143 Solute carrier family 22 member 7 SLC22A7 0.0406
24 Thymidylate synthase TMP1 0.0361
359 Thymidylate synthase TYMS 0.0361
2626 Thymidylate synthase thyA 0.0361
2729 Thymidylate synthase thyA 0.0361
5352 Thymidylate synthase THYA 0.0361
603 DNA polymerase alpha catalytic subunit POLA1 0.0351
4512 Cytochrome P450 3A4 CYP3A4 0.0312
1673 GTP cyclohydrolase I GCH1 0.0311
3302 GTP cyclohydrolase I folE 0.0311
3611 Cytidine deaminase cdd 0.0303
3707 Cytidine deaminase cdd 0.0303
4211 Cytidine deaminase CDA 0.0303
587 Serum albumin ALB 0.0302
4757 Cytochrome P450 2C9 CYP2C9 0.0281
2837 Xanthosine phosphorylase xapA 0.0273
2164 Multidrug resistance-associated protein 4 ABCC4 0.027
20 Prostaglandin G/H synthase 1 PTGS1 0.0256
290 Prostaglandin G/H synthase 2 PTGS2 0.025
6148 Multidrug resistance-associated protein 7 ABCC10 0.0245
3300 Xanthine phosphoribosyltransferase xpt 0.0238
3681 Xanthine phosphoribosyltransferase gpt 0.0238
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0227
752 Large structural protein L 0.0227
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0225
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0219
6136 Multidrug resistance-associated protein 5 ABCC5 0.0208
1588 Multidrug resistance protein 1 ABCB1 0.0201
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0198
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0198
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0196
6145 Solute carrier family 22 member 1 SLC22A1 0.0189
6144 Solute carrier family 22 member 2 SLC22A2 0.0182
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0179
1830 5'-nucleotidase NT5E 0.0176
3639 Thymidine phosphorylase deoA 0.0173
3936 Thymidine phosphorylase TYMP 0.0173
4924 Cytochrome P450 2C8 CYP2C8 0.0173
125 DNA polymerase beta POLB 0.0163
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0161
118 Organic cation/carnitine transporter 2 SLC22A5 0.016
6021 Adenosine kinase ADK 0.0159
4200 Cytochrome P450 1A2 CYP1A2 0.0157
702 UMP-CMP kinase CMPK1 0.0156
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0153
633 Penicillin-binding proteins 1A/1B pbpA 0.0149
365 Dihydrofolate reductase DHFR 0.0147
2381 Dihydrofolate reductase DFR1 0.0147
2833 Dihydrofolate reductase Not Available 0.0147
2931 Dihydrofolate reductase folA 0.0147
3544 Dihydrofolate reductase folA 0.0147
3682 Dihydrofolate reductase folA 0.0147
6642 Dihydrofolate reductase folA 0.0147
6756 Dihydrofolate reductase dfrA 0.0147
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0145
6016 Cytochrome P450 2C19 CYP2C19 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
592 Carbonic anhydrase 4 CA4 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
1405 Thiopurine S-methyltransferase TPMT 0.0137
6107 Cytochrome P450 3A7 CYP3A7 0.0135
295 Carbonic anhydrase 1 CA1 0.0133
4118 Cytochrome P450 3A5 CYP3A5 0.0133
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0125
4119 Cytochrome P450 2D6 CYP2D6 0.0125
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
357 Carbonic anhydrase 2 CA2 0.0116
6031 Cytochrome P450 3A43 CYP3A43 0.0114
6020 Aldehyde oxidase AOX1 0.0112
4790 Glycosyltransferase GtfA gtfA 0.011
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0106
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0106
776 Bile salt export pump ABCB11 0.0104
3917 Methylenetetrahydrofolate reductase MTHFR 0.0103
862 Multidrug resistance-associated protein 1 ABCC1 0.0101
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.01
645 Penicillin-binding protein 1A mrcA 0.01
5805 Penicillin-binding protein 1A ponA 0.01
6185 Penicillin-binding protein 1A mrcA 0.01
6799 Penicillin-binding protein 1A pbpA 0.01
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0099
3947 Xanthine dehydrogenase/oxidase XDH 0.0097
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0094
4226 Uridine phosphorylase 2 UPP2 0.0094
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.009
6024 Cytochrome P450 1A1 CYP1A1 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
738 Monocarboxylate transporter 1 SLC16A1 0.009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0089
6111 DNA polymerase epsilon subunit 4 POLE4 0.0087
6112 DNA polymerase epsilon subunit 3 POLE3 0.0087
6110 DNA polymerase epsilon subunit 2 POLE2 0.0087
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0087
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0087
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0086
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0086
4225 Uridine phosphorylase 1 UPP1 0.0085
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0081
5718 Cytochrome P450 2A6 CYP2A6 0.0081
413 Amidophosphoribosyltransferase PPAT 0.0077
2515 Amidophosphoribosyltransferase purF 0.0077
3714 Amidophosphoribosyltransferase purF 0.0077
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
267 Plasminogen activator inhibitor 1 SERPINE1 0.0067
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0066
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0062
5626 Nucleoside diphosphate kinase B NME2 0.006
6221 Steroid hormone receptor ERR1 ESRRA 0.0059
2320 Thymidine kinase, cytosolic TK1 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0059
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0056
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
833 Organic cation/carnitine transporter 1 SLC22A4 0.0054
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0054
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0052
6013 Cytochrome P450 2E1 CYP2E1 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
238 Peroxisome proliferator-activated receptor gamma PPARG 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0048
373 Transthyretin TTR 0.0046
3809 Estrogen-related receptor gamma ESRRG 0.0045
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6106 Cytochrome P450 2C18 CYP2C18 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
6141 Sodium/bile acid cotransporter SLC10A1 0.0041
275 Arachidonate 5-lipoxygenase ALOX5 0.004
6030 Cytochrome P450 2B6 CYP2B6 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
3811 Cytochrome P450 19A1 CYP19A1 0.0037
244 Angiotensin-converting enzyme ACE 0.0036
6131 Carbonic anhydrase 14 CA14 0.0035
492 Histamine H1 receptor HRH1 0.0035
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
3932 Glutathione S-transferase A2 GSTA2 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
654 Flavin reductase BLVRB 0.0029
6147 Solute carrier family 22 member 3 SLC22A3 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
1757 Myeloperoxidase MPO 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
293 Gamma-glutamyl hydrolase GGH 0.0026
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
1650 Heme carrier protein 1 SLC46A1 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0021
3941 Amine oxidase [flavin-containing] A MAOA 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
146 Androgen receptor AR 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
1654 Interleukin-1 beta IL1B 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
6014 Cytochrome P450 2A13 CYP2A13 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
494 Caspase-1 CASP1 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0015
1507 Cytochrome c CYCS 0.0015
4217 Telomerase reverse transcriptase TERT 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
2077 Caspase-3 CASP3 0.0013
819 Penicillin-binding protein 4 dacB 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
6137 Multidrug resistance-associated protein 6 ABCC6 0.0012
2021 Thrombomodulin THBD 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
997 Protein kinase C beta type PRKCB 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
6218 Pannexin-1 PANX1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
5818 Folate receptor alpha FOLR1 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
3587 Gastrotropin FABP6 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
124 Histamine H2 receptor HRH2 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0006
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0006
3810 Catechol O-methyltransferase COMT 0.0006
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0006
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0005
4604 Liver carboxylesterase 1 CES1 0.0005
136 Estrogen receptor ESR1 0.0005
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