DT-Web: DB00300

Identification

Name

Tenofovir

Accession Number

DB00300 (APRD01248)

Type

small molecule

Description

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread®, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. [Wikipedia] In vivo tenofovir disoproxil fumarate is converted to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'-monophosphate.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

287.2123

Groups

approved

Monoisotopic Weight

287.078340473

Pharmacology

Indication

Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.

Mechanism of action

Tenofovir inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. Specifically, the drugs are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain. However, unlike the natural deoxynucleotides substrates, NRTIs and NTRTIs (nucleoside/tide reverse transcriptase inhibitors) lack a 3'-hydroxyl group on the deoxyribose moiety. As a result, following incorporation of an NRTI or an NtRTI, the next incoming deoxynucleotide cannot form the next 5'-3' phosphodiester bond needed to extend the DNA chain. Thus, when an NRTI or NtRTI is incorporated, viral DNA synthesis is halted, a process known as chain termination. All NRTIs and NtRTIs are classified as competitive substrate inhibitors.

Absorption

Tenofovir disoproxil fumarate is the water soluble diester prodrug of the active ingredient tenofoir. The oral bioavailability in fasted patients is approximately 25%. When a single oral dose (300 mg) is given to HIV-1 infected subjects in the fasted state, the maximum serum concentration was achieved in 1.0 ? 0.4 hours (Tmax). Cmax and AUC values are 0.30 ? 0.09 ug/mL and 2.29 ? 0.69 ug?hr/mL. Administration of food (high fat meal containing 40 to 50% fat) increases the oral bioavailability, with an increase in the AUC of approximately 40%. Cmax is lower in the oral powder, compared to the tablet formulation. However, the mean AUC is similar between the two formulations.

Protein binding

Very low: < 0.7% to human plasma proteins and < 7.2% to serum proteins

Biotransformation

The cytochrome P450 enzyme system is not involved with the metabolism of tenofovir disoproxil or tenofovir.

Route of elimination

When tenofovir is given IV, 70-80% of the dose is recovered in the urine as unchanged drug within 72 hours of administration. Tenofovir is eliminated by a combination of glomerular filtration and active tubular secretion. There may be competition for elimination with other compounds that are also renally eliminated.

Toxicity

Limited clinical experience at doses higher than the therapeutic dose of tenofovir 300 mg is available. In Study 901 tenofovir disoproxil fumarate 600 mg was administered to 8 patients orally for 28 days. No severe adverse reactions were reported. The effects of higher doses are not known.

Affected organisms

Human Immunodeficiency Virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Concomitant therapy may result in decreased serum levels of Atazanavir and increased levels of Tenofovir. Concomitant therapy should only be used with the inclusion of Ritonavir.
Didanosine	Tenofovir may decrease the therapeutic effects and increase the adverse effects of Didanosine. Monitor for changes in virologic response and Didanosine toxicity during concomitant therapy.
Valganciclovir	The excretion rates of Valganciclovir and/or Tenofovir may decrease as both drugs are eliminated by active tubular secretion. Monitor for increased serum concentrations and toxicity of both agents.

Food Interactions

When given with a high-fat meal, the oral bioavailability, AUC, and Cmax increased.

DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	cross-linking/alkylation
References	De Clercq E: Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33. - Pubmed De Clercq E: A 40-Year Journey in Search of Selective Antiviral Chemotherapy. Annu Rev Pharmacol Toxicol. 2010 Jan 18. - Pubmed Molina JM, Cox SL: Emtricitabine: a novel nucleoside reverse transcriptase inhibitor. Drugs Today (Barc). 2005 Apr;41(4):241-52. - Pubmed
DTHybrid score	Not Available

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2798
Adenylate kinase 2, mitochondrial
Name	Adenylate kinase 2, mitochondrial
Gene Name	AK2
Actions	substrate
References	Antoniou T, Park-Wyllie LY, Tseng AL: Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection. Pharmacotherapy. 2003 Jan;23(1):29-43. - Pubmed http://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	Not Available
GTP:AMP phosphotransferase AK4, mitochondrial
Name	GTP:AMP phosphotransferase AK4, mitochondrial
Gene Name	Not Available
Actions	substrate
References	Antoniou T, Park-Wyllie LY, Tseng AL: Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection. Pharmacotherapy. 2003 Jan;23(1):29-43. - Pubmed http://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	Not Available
Nucleoside diphosphate kinase A
Name	Nucleoside diphosphate kinase A
Gene Name	NME1
Actions	substrate
References	http://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	1.1943
Nucleoside diphosphate kinase B
Name	Nucleoside diphosphate kinase B
Gene Name	NME2
Actions	substrate
References	http://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	0.2271

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	substrate
References	Cihlar T, Ho ES, Lin DC, Mulato AS: Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):641-8. - Pubmed Uwai Y, Ida H, Tsuji Y, Katsura T, Inui K: Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5. Epub 2007 Feb 15. - Pubmed
DTHybrid score	0.4176
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate
References	Uwai Y, Ida H, Tsuji Y, Katsura T, Inui K: Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5. Epub 2007 Feb 15. - Pubmed
DTHybrid score	0.3241
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	substrate
References	Pushpakom SP, Liptrott NJ, Rodriguez-Novoa S, Labarga P, Soriano V, Albalater M, Hopper-Borge E, Bonora S, Di Perri G, Back DJ, Khoo S, Pirmohamed M, Owen A: Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. J Infect Dis. 2011 Jul 1;204(1):145-53. doi: 10.1093/infdis/jir215. - Pubmed
DTHybrid score	0.1556
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate
References	Imaoka T, Kusuhara H, Adachi M, Schuetz JD, Takeuchi K, Sugiyama Y: Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007 Feb;71(2):619-27. Epub 2006 Nov 16. - Pubmed
DTHybrid score	0.279
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Izzedine H, Hulot JS, Villard E, Goyenvalle C, Dominguez S, Ghosn J, Valantin MA, Lechat P, Deray AG: Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. J Infect Dis. 2006 Dec 1;194(11):1481-91. Epub 2006 Oct 26. - Pubmed
DTHybrid score	0.27

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.164
1588	Multidrug resistance protein 1	ABCB1	0.1507
4757	Cytochrome P450 2C9	CYP2C9	0.1303
1024	Solute carrier family 22 member 11	SLC22A11	0.1251
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1094
862	Multidrug resistance-associated protein 1	ABCC1	0.1068
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1021
6143	Solute carrier family 22 member 7	SLC22A7	0.099
6136	Multidrug resistance-associated protein 5	ABCC5	0.096
6016	Cytochrome P450 2C19	CYP2C19	0.0946
4924	Cytochrome P450 2C8	CYP2C8	0.0945
587	Serum albumin	ALB	0.0893
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0856
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0853
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0853
4118	Cytochrome P450 3A5	CYP3A5	0.0851
4119	Cytochrome P450 2D6	CYP2D6	0.0839
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0779
6147	Solute carrier family 22 member 3	SLC22A3	0.0765
20	Prostaglandin G/H synthase 1	PTGS1	0.0726
290	Prostaglandin G/H synthase 2	PTGS2	0.0703
6145	Solute carrier family 22 member 1	SLC22A1	0.0682
776	Bile salt export pump	ABCB11	0.0681
6144	Solute carrier family 22 member 2	SLC22A2	0.0668
2633	Anaerobic ribonucleoside-triphosphate reductase	NRDD	0.0662
6107	Cytochrome P450 3A7	CYP3A7	0.0656
6024	Cytochrome P450 1A1	CYP1A1	0.0652
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.063
2638	Formate dehydrogenase H	fdhF	0.0571
6013	Cytochrome P450 2E1	CYP2E1	0.0571
118	Organic cation/carnitine transporter 2	SLC22A5	0.0566
6030	Cytochrome P450 2B6	CYP2B6	0.0528
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0469
4773	Deoxycytidine kinase	DCK	0.0463
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0443
2748	Cysteine desulfurase	sufS	0.0433
702	UMP-CMP kinase	CMPK1	0.0425
6141	Sodium/bile acid cotransporter	SLC10A1	0.0406
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0391
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0378
404	DNA gyrase subunit A	gyrA	0.0376
6224	DNA gyrase subunit A	gyrA	0.0376
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0376
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0369
817	DNA topoisomerase 2-alpha	TOP2A	0.0348
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0342
1898	Cytochrome P450 1B1	CYP1B1	0.0339
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0338
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.033
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0329
738	Monocarboxylate transporter 1	SLC16A1	0.0321
24	Thymidylate synthase	TMP1	0.0319
359	Thymidylate synthase	TYMS	0.0319
2626	Thymidylate synthase	thyA	0.0319
2729	Thymidylate synthase	thyA	0.0319
5352	Thymidylate synthase	THYA	0.0319
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0317
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0314
477	DNA topoisomerase 4 subunit A	parC	0.0304
886	DNA topoisomerase 4 subunit A	parC	0.0304
6226	DNA topoisomerase 4 subunit A	parC	0.0304
6137	Multidrug resistance-associated protein 6	ABCC6	0.0298
5718	Cytochrome P450 2A6	CYP2A6	0.0297
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0263
833	Organic cation/carnitine transporter 1	SLC22A4	0.026
36	Insulin receptor	INSR	0.0258
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0255
3947	Xanthine dehydrogenase/oxidase	XDH	0.0254
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0233
3270	Elongation factor G	fusA	0.0218
338	DNA polymerase	UL30	0.0216
379	DNA polymerase	UL54	0.0216
697	DNA polymerase	ORF28	0.0216
2482	DNA polymerase	43	0.0216
4104	DNA polymerase	BALF5	0.0216
645	Penicillin-binding protein 1A	mrcA	0.0212
5805	Penicillin-binding protein 1A	ponA	0.0212
6185	Penicillin-binding protein 1A	mrcA	0.0212
6799	Penicillin-binding protein 1A	pbpA	0.0212
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0212
3611	Cytidine deaminase	cdd	0.0208
3707	Cytidine deaminase	cdd	0.0208
4211	Cytidine deaminase	CDA	0.0208
3811	Cytochrome P450 19A1	CYP19A1	0.0207
273	Apoptosis regulator Bcl-2	BCL2	0.0206
2016	Dipeptidase 1	DPEP1	0.0197
633	Penicillin-binding proteins 1A/1B	pbpA	0.0195
6106	Cytochrome P450 2C18	CYP2C18	0.0192
543	Penicillin-binding protein 1B	mrcB	0.019
6186	Penicillin-binding protein 1B	ponB	0.019
6822	Penicillin-binding protein 1b	pbp1b	0.019
6844	Penicillin-binding protein 1b	pbp1b	0.019
6167	Organic solute transporter subunit beta	OSTB	0.019
6166	Organic solute transporter subunit alpha	OSTA	0.0189
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0189
6020	Aldehyde oxidase	AOX1	0.0187
1882	Ras-related C3 botulinum toxin substrate 1	RAC1	0.0187
2170	Transforming protein RhoA	RHOA	0.0187
3197	GDP-mannose mannosyl hydrolase	nudD	0.0187
5628	Probable GTPase engC	rsgA	0.0187
5630	ADP-ribosylation factor-like protein 5A	ARL5A	0.0187
5618	ADP-ribosylation factor 4	ARF4	0.0187
5624	GTPase	rab6	0.0187
136	Estrogen receptor	ESR1	0.0187
5627	GDP-mannose 4,6-dehydratase	gca	0.0187
3366	GTP-binding protein engA	der	0.0187
70	Type-1 angiotensin II receptor	AGTR1	0.0183
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0182
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0181
4604	Liver carboxylesterase 1	CES1	0.0177
3115	Ras-related protein Rab-9	RAB9A	0.0175
22	30S ribosomal protein S4	rpsD	0.0173
6714	30S ribosomal protein S4	rpsD	0.0173
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0172
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0171
6171	Solute carrier family 28 member 3	SLC28A3	0.0167
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0166
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0163
140	30S ribosomal protein S9	rpsI	0.0163
6719	30S ribosomal protein S9	rpsI	0.0163
6725	30S ribosomal protein S9	rpsI	0.0163
3335	Probable GTP-binding protein engB	engB	0.0162
3354	Ras-related protein Rap-2a	RAP2A	0.0162
3107	Putative GTP pyrophosphokinase	relA	0.0162
5619	GDP-mannose 4,6 dehydratase	GMDS	0.0161
5923	Microtubule-associated protein tau	MAPT	0.0159
5924	Microtubule-associated protein 4	MAP4	0.0159
3170	Elongation factor Tu-B	tufB	0.0157
3396	Elongation factor Tu	tufA	0.0156
5621	Elongation factor Tu	tuf	0.0156
3261	Signal recognition particle protein	ffh	0.0155
275	Arachidonate 5-lipoxygenase	ALOX5	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
1650	Heme carrier protein 1	SLC46A1	0.0149
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0149
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0146
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0146
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0146
1852	Microtubule-associated protein 2	MAP2	0.0146
6750	ADP-ribosylation factor 6	ARF6	0.0145
2521	Cell division protein ftsZ	ftsZ	0.0145
3301	Cell division protein ftsZ	ftsZ	0.0145
357	Carbonic anhydrase 2	CA2	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
492	Histamine H1 receptor	HRH1	0.0144
293	Gamma-glutamyl hydrolase	GGH	0.0143
6556	Elongation factor Tu GTP-binding domain-containing protein 1	EFTUD1	0.0141
592	Carbonic anhydrase 4	CA4	0.0141
4192	DNA topoisomerase 2-beta	TOP2B	0.0141
1596	Protein-glutamine gamma-glutamyltransferase 2	TGM2	0.0141
6447	Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	0.0141
1405	Thiopurine S-methyltransferase	TPMT	0.0139
1830	5'-nucleotidase	NT5E	0.0138
6149	Solute carrier family 22 member 10	SLC22A10	0.0137
295	Carbonic anhydrase 1	CA1	0.0137
33	Cystine/glutamate transporter	SLC7A11	0.0137
6790	Elongation factor 2	EEF2	0.0136
3639	Thymidine phosphorylase	deoA	0.0131
3936	Thymidine phosphorylase	TYMP	0.0131
3941	Amine oxidase [flavin-containing] A	MAOA	0.013
1758	GTPase HRas	HRAS	0.0129
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
6085	Fatty acid-binding protein, intestinal	FABP2	0.0129
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0127
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0127
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0127
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0127
3685	Catabolite gene activator	crp	0.0126
4655	Adenylate cyclase	cyaC	0.0126
4759	Adenylate cyclase	cyaB2	0.0126
908	Glutathione S-transferase theta-1	GSTT1	0.0124
29	Tubulin beta-1 chain	TUBB1	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
438	Taste receptor type 1 member 2	TAS1R2	0.0122
1757	Myeloperoxidase	MPO	0.0121
6316	ADP-ribosylation factor 1	ARF1	0.0121
3587	Gastrotropin	FABP6	0.012
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
558	Solute carrier family 12 member 1	SLC12A1	0.0118
318	Alpha-2A adrenergic receptor	ADRA2A	0.0116
125	DNA polymerase beta	POLB	0.0116
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0114
2632	Adenylosuccinate synthetase	purA	0.0113
3323	Adenylosuccinate synthetase	purA	0.0113
3975	Adenylosuccinate synthetase	ADSS	0.0113
4598	Adenylosuccinate synthetase	Adss	0.0113
6817	Adenylosuccinate synthetase	purA	0.0113
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
3686	Acyl-CoA thioesterase I precursor	tesA	0.0111
124	Histamine H2 receptor	HRH2	0.0111
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0108
2443	Azurin	azu	0.0108
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0108
824	Sodium-dependent serotonin transporter	SLC6A4	0.0108
4760	Mll3241 protein	mll3241	0.0107
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0107
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0106
115	Penicillin-binding protein 2	mrdA	0.0106
6069	Penicillin-binding protein 2	mrdA	0.0106
6118	Penicillin-binding protein 2	penA	0.0106
6187	Penicillin-binding protein 2	pbpA	0.0106
6686	Penicillin-binding protein 2	pbp2	0.0106
6939	Penicillin-binding protein 2	mrdA	0.0106
7163	Penicillin-binding protein 2	pbpA	0.0106
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0104
904	Glutathione S-transferase P	GSTP1	0.0104
26	Vascular endothelial growth factor receptor 3	FLT4	0.0102
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0101
5482	Sialidase-2	NEU2	0.0101
831	D(2) dopamine receptor	DRD2	0.01
6033	High affinity interleukin-8 receptor A	CXCR1	0.01
161	Tubulin beta chain	TUBB	0.0099
312	Tubulin beta chain	TUB2	0.0099
373	Transthyretin	TTR	0.0099
4120	NADPH--cytochrome P450 reductase	POR	0.0099
2320	Thymidine kinase, cytosolic	TK1	0.0099
1	Peptidoglycan synthetase ftsI	ftsI	0.0099
4155	Peptidoglycan synthetase ftsI	ftsI	0.0099
887	DNA gyrase subunit B	gyrB	0.0099
4150	DNA gyrase subunit B	gyrB	0.0099
6225	DNA gyrase subunit B	gyrB	0.0099
32	Vascular endothelial growth factor receptor 1	FLT1	0.0098
1198	Serum paraoxonase/arylesterase 1	PON1	0.0097
6223	Penicillin-binding protein 1C	pbpC	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
2757	Inorganic pyrophosphatase	ppa	0.0096
6238	Inorganic pyrophosphatase	ppa	0.0096
6968	Inorganic pyrophosphatase	PPA1	0.0096
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0095
5818	Folate receptor alpha	FOLR1	0.0094
504	Mast/stem cell growth factor receptor	KIT	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0092
5353	Glutamate decarboxylase alpha	gadA	0.0091
2539	Tubulin alpha-1 chain	TUBA4A	0.009
556	Alpha-1A adrenergic receptor	ADRA1A	0.009
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.009
885	5-hydroxytryptamine 1B receptor	HTR1B	0.009
23	D(1A) dopamine receptor	DRD1	0.0089
1648	Elastin	ELN	0.0089
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0088
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0086
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0086
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0085
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0085
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0084
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0084
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0084
165	FL cytokine receptor	FLT3	0.0084
2647	RNA-directed RNA polymerase	P2	0.0084
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0084
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0083
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0083
723	Cytosolic phospholipase A2	PLA2G4A	0.0083
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0083
2727	S-adenosylmethionine synthetase	metK	0.0083
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0083
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0083
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0082
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0082
6126	Carbonic anhydrase 7	CA7	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0081
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0081
146	Androgen receptor	AR	0.008
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.008
756	Sex hormone-binding globulin	SHBG	0.008
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0079
2808	Chloramphenicol acetyltransferase 3	cat3	0.0079
332	Beta-lactamase	blaZ	0.0079
2478	Beta-lactamase	ampC	0.0079
2613	Beta-lactamase	ampC	0.0079
2635	Beta-lactamase	ampC	0.0079
2700	Beta-lactamase	penP	0.0079
5445	Beta-lactamase	blaB	0.0079
6019	Beta-lactamase	SHV-7	0.0079
6701	Beta-lactamase	cphA	0.0079
6043	Putative G-protein coupled receptor 44	GPR44	0.0078
407	Vascular endothelial growth factor receptor 2	KDR	0.0078
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0077
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0077
3010	Regulatory protein blaR1	blaR1	0.0077
2149	Angiogenin	ANG	0.0077
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0076
6220	Aryl hydrocarbon receptor	AHR	0.0075
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0075
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0074
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0074
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0074
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.0073
6395	Myosin-14	MYH14	0.0073
4600	Malonamidase E2	Not Available	0.0072
777	Tumor necrosis factor	TNF	0.0072
6168	Solute carrier family 22 member 16	SLC22A16	0.0072
185	Vasopressin V1a receptor	AVPR1A	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
718	Folate receptor gamma	FOLR3	0.0071
299	Folate receptor beta	FOLR2	0.0071
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0071
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.007
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.007
2717	Folylpolyglutamate synthase	fgs	0.007
3957	Adenosine deaminase	ADA	0.007
322	Vasopressin V2 receptor	AVPR2	0.007
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0069
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0069
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0069
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0068
571	Melatonin receptor type 1A	MTNR1A	0.0068
362	Melatonin receptor type 1B	MTNR1B	0.0068
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0067
1867	Major prion protein	PRNP	0.0067
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0067
3939	Amine oxidase [flavin-containing] B	MAOB	0.0067
614	Progesterone receptor	PGR	0.0067
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0066
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0066
16	Adenosine A1 receptor	ADORA1	0.0066
4217	Telomerase reverse transcriptase	TERT	0.0066
468	Cytochrome P450 4A11	CYP4A11	0.0065
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0065
465	Calmodulin	CALM1	0.0064
193	Beta-1 adrenergic receptor	ADRB1	0.0063
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0063
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0063
629	Alpha-2B adrenergic receptor	ADRA2B	0.0062
731	HIV-1 protease	HIV-1 protease	0.0062
632	Alpha-1B adrenergic receptor	ADRA1B	0.0062
6014	Cytochrome P450 2A13	CYP2A13	0.0062
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0061
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0061
130	Prostacyclin synthase	PTGIS	0.0061
244	Angiotensin-converting enzyme	ACE	0.0061
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.006
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.006
3923	Cholinesterase	BCHE	0.0059
6207	30S ribosomal protein S14	rpsN	0.0058
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0058
6209	30S ribosomal protein S19	rpsS	0.0058
6712	30S ribosomal protein S19	rpsS	0.0058
6726	30S ribosomal protein S19	rpsS	0.0058
365	Dihydrofolate reductase	DHFR	0.0058
2381	Dihydrofolate reductase	DFR1	0.0058
2833	Dihydrofolate reductase	Not Available	0.0058
2931	Dihydrofolate reductase	folA	0.0058
3544	Dihydrofolate reductase	folA	0.0058
3682	Dihydrofolate reductase	folA	0.0058
6642	Dihydrofolate reductase	folA	0.0058
6756	Dihydrofolate reductase	dfrA	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0057
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0057
6218	Pannexin-1	PANX1	0.0057
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0057
6146	High affinity copper uptake protein 1	SLC31A1	0.0056
2249	Aspartate aminotransferase	aspC	0.0056
2671	Aspartate aminotransferase	aspC	0.0056
5490	Aspartate aminotransferase	Not Available	0.0056
869	Estrogen receptor beta	ESR2	0.0056
714	Glutathione reductase, mitochondrial	GSR	0.0055
6031	Cytochrome P450 3A43	CYP3A43	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
896	Glutathione S-transferase Mu 1	GSTM1	0.0054
117	Sterol O-acyltransferase 1	SOAT1	0.0054
408	Riboflavin kinase	RFK	0.0053
2021	Thrombomodulin	THBD	0.0053
1178	Adenosine A2a receptor	ADORA2A	0.0053
1629	Transcription factor AP-1	JUN	0.0053
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
1313	Lactoylglutathione lyase	GLO1	0.0053
638	D(3) dopamine receptor	DRD3	0.0052
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0052
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0052
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0052
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0052
713	Sodium-dependent dopamine transporter	SLC6A3	0.0052
6163	Copper-transporting ATPase 2	ATP7B	0.0051
6165	Copper-transporting ATPase 1	ATP7A	0.0051
1714	Mitogen-activated protein kinase 3	MAPK3	0.0051
65	Matrix metalloproteinase-9	Not Available	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
789	Alpha-1D adrenergic receptor	ADRA1D	0.0051
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.005
6042	Prostaglandin reductase 2	PTGR2	0.005
527	Prostacyclin receptor	PTGIR	0.005
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.005
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.005
378	Alpha-2C adrenergic receptor	ADRA2C	0.005
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.005
672	Prostaglandin F2-alpha receptor	PTGFR	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
952	Dipeptidyl peptidase 4	DPP4	0.0048
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0048
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0048
489	Monocarboxylate transporter 2	SLC16A7	0.0048
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0048
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0048
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0048
3932	Glutathione S-transferase A2	GSTA2	0.0047
766	Beta-2 adrenergic receptor	ADRB2	0.0047
4122	Histone deacetylase 2	HDAC2	0.0047
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0046
867	Penicillin-binding protein 3	pbpC	0.0046
6119	Penicillin-binding protein 3	pbp3	0.0046
7154	Penicillin-binding protein 3	pbp3	0.0046
7157	Penicillin-binding protein 3	LMHCC_2184	0.0046
7162	Penicillin-binding protein 3	pbpB	0.0046
7172	Penicillin-binding protein 3	pbp3	0.0046
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0046
1654	Interleukin-1 beta	IL1B	0.0045
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0045
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
6044	Serum paraoxonase/lactonase 3	PON3	0.0044
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0044
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0044
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0044
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0043
3810	Catechol O-methyltransferase	COMT	0.0043
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0042
183	Vascular endothelial growth factor A	VEGFA	0.0042
53	Solute carrier family 12 member 5	SLC12A5	0.0042
663	Solute carrier family 12 member 4	SLC12A4	0.0042
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0041
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.004
103	Muscarinic acetylcholine receptor M1	CHRM1	0.004
432	D(4) dopamine receptor	DRD4	0.004
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.004
4226	Uridine phosphorylase 2	UPP2	0.0039
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0039
2391	Ferrochelatase	hemH	0.0039
6502	Ferrochelatase	DKFZp686P18130	0.0039
1591	Ferrochelatase, mitochondrial	FECH	0.0039
310	Solute carrier family 12 member 2	SLC12A2	0.0039
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0039
7	Nitric oxide synthase, inducible	NOS2	0.0039
380	Cytochrome P450 17A1	CYP17A1	0.0038
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0038
2232	Interleukin-5	IL5	0.0037
1593	Mucin-2	MUC2	0.0037
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0037
494	Caspase-1	CASP1	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0037
1792	Tissue-type plasminogen activator	PLAT	0.0037
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0037
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0036
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0036
4225	Uridine phosphorylase 1	UPP1	0.0036
6131	Carbonic anhydrase 14	CA14	0.0035
1507	Cytochrome c	CYCS	0.0035
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0034
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0034
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0034
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0034
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0034
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0034
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0034
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0034
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0034
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0034
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0034
6559	Cytochrome c oxidase subunit 2	ctaC	0.0034
6669	Cytochrome c oxidase subunit 2	ctaC	0.0034
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0034
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0034
6558	Cytochrome c oxidase subunit 1	ctaD	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
413	Amidophosphoribosyltransferase	PPAT	0.0034
2515	Amidophosphoribosyltransferase	purF	0.0034
3714	Amidophosphoribosyltransferase	purF	0.0034
712	Tubulin alpha chain	TUB1	0.0034
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0034
737	Mineralocorticoid receptor	NR3C2	0.0034
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0034
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0033
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0033
3760	Penicillin-binding protein 5 precursor	dacA	0.0033
6122	Carbonic anhydrase 3	CA3	0.0033
3007	Carbonic anhydrase 12	CA12	0.0033
260	Cytochrome P450 51	ERG11	0.0033
761	Cytochrome P450 51	ERG11	0.0033
3163	Cytochrome P450 51	cyp51	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
4205	Carbonic anhydrase 9	CA9	0.0033
76	Nitric-oxide synthase, brain	NOS1	0.0032
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0032
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0031
758	Thyroid hormone receptor alpha	THRA	0.0031
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0031
2540	Choloylglycine hydrolase	cbh	0.0031
1123	Eosinophil cationic protein	RNASE3	0.0031
2077	Caspase-3	CASP3	0.0031
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0031
2449	Tubulin alpha-3 chain	TUBA1A	0.0031
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0031
1192	Sulfotransferase 1A1	SULT1A1	0.0031
291	Nitric-oxide synthase, endothelial	NOS3	0.0031
131	Synaptic vesicular amine transporter	SLC18A2	0.0031
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
818	50S ribosomal protein L10	rplJ	0.003
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
751	Potassium channel subfamily K member 6	KCNK6	0.003
173	Toll-like receptor 7	TLR7	0.003
3830	Calreticulin	CALR	0.003
819	Penicillin-binding protein 4	dacB	0.003
6501	Fatty acid-binding protein, liver	FABP1	0.003
654	Flavin reductase	BLVRB	0.0029
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0028
1039	Histone deacetylase 9	HDAC9	0.0028
172	Potassium channel subfamily K member 1	KCNK1	0.0028
6034	Hydroxyindole O-methyltransferase	ASMT	0.0027
6035	Nuclear receptor ROR-beta	RORB	0.0027
6036	Eosinophil peroxidase	EPX	0.0027
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0027
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0027
5126	Arginase	rocF	0.0027
1025	Aquaporin-1	AQP1	0.0027
517	Alcohol dehydrogenase 1C	ADH1C	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
871	Glucocorticoid receptor	NR3C1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1569	G1/S-specific cyclin-D1	CCND1	0.0027
3809	Estrogen-related receptor gamma	ESRRG	0.0026
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0026
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0026
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0026
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0026
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
207	Glutathione synthetase	GSS	0.0025
5269	Glutathione synthetase	gshB	0.0025
1760	Aminopeptidase N	ANPEP	0.0025
6843	Aminopeptidase N	pepN	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
340	Apoptotic protease-activating factor 1	APAF1	0.0025
6500	Phospholipase A2	PLA2G1B	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
5682	Ribonuclease pancreatic	RNASE1	0.0025
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
459	Retinoic acid receptor RXR-alpha	RXRA	0.0024
2091	Endoplasmin	HSP90B1	0.0024
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0024
6211	Tubulin epsilon chain	TUBE1	0.0024
6210	Tubulin delta chain	TUBD1	0.0024
6212	Tubulin gamma-1 chain	TUBG1	0.0024
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0024
765	Indoleamine 2,3-dioxygenase	IDO1	0.0024
6070	Nischarin	NISCH	0.0024
6102	Arylamine N-acetyltransferase 2	NAT2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0023
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
6151	Monocarboxylate transporter 10	SLC16A10	0.0021
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0021
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0021
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
921	Glutamate receptor 2	GRIA2	0.0021
822	Aldose reductase	AKR1B1	0.0021
634	Squalene monooxygenase	SQLE	0.002
7196	Squalene monooxygenase	ERG1	0.002
4034	Glutaredoxin-1	GLRX	0.002
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.002
910	Epididymal secretory glutathione peroxidase	GPX5	0.002
903	Glutathione S-transferase A5	GSTA5	0.002
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.002
4037	Hypothetical protein	GPX1	0.002
4297	Hypothetical protein	SP_1951	0.002
4521	Hypothetical protein	BC_2969	0.002
4540	Hypothetical protein	TM_1070	0.002
4555	Hypothetical protein	MT1739	0.002
4569	Hypothetical protein	mshD	0.002
4578	Hypothetical protein	PA3270	0.002
4747	Hypothetical protein	PA3967	0.002
5177	Hypothetical protein	TM_0096	0.002
5194	Hypothetical protein	PA1204	0.002
5240	Hypothetical protein	Rv2991	0.002
5370	Hypothetical protein	TM_1158	0.002
5710	Hypothetical protein	Tb927.5.1360	0.002
1928	Leukotriene C4 synthase	LTC4S	0.002
4029	Microsomal glutathione S-transferase 3	MGST3	0.002
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.002
4032	Microsomal glutathione S-transferase 1	MGST1	0.002
4036	Glutathione peroxidase 6	GPX6	0.002
911	Glutathione peroxidase 3	GPX3	0.002
4040	Glutathione peroxidase 7	GPX7	0.002
907	Glutathione peroxidase 2	GPX2	0.002
906	Glutathione peroxidase 1	GPX1	0.002
4035	Glutathione S-transferase Mu 5	GSTM5	0.002
900	Glutathione S-transferase A4	GSTA4	0.002
4042	Glutathione transferase omega-2	GSTO2	0.002
4038	Glutathione peroxidase 4	GPX4	0.002
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.002
4033	S-formylglutathione hydrolase	ESD	0.002
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.002
1820	Beta-nerve growth factor	NGF	0.002
1630	Integrin beta-2	ITGB2	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
716	5-hydroxytryptamine 7 receptor	HTR7	0.0019
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0019
6837	Serine/threonine-protein kinase 17B	STK17B	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
122	P2Y purinoceptor 12	P2RY12	0.0018
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
898	Glutathione S-transferase A3	GSTA3	0.0018
897	Glutathione S-transferase kappa 1	GSTK1	0.0018
909	Maleylacetoacetate isomerase	GSTZ1	0.0018
1176	Mitogen-activated protein kinase 1	MAPK1	0.0018
5304	UPF0166 protein TM_0021	TM_0021	0.0018
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0018
3199	Phosphopantetheine adenylyltransferase	coaD	0.0018
3543	Phosphopantetheine adenylyltransferase	coaD	0.0018
3567	Phosphopantetheine adenylyltransferase	coaD	0.0018
5289	Phosphopantetheine adenylyltransferase	coaD	0.0018
5288	Shikimate kinase	aroK	0.0018
5287	Signaling protein	Not Available	0.0018
5259	Transcriptional regulator	ntrC1	0.0018
6699	Transcriptional regulator	Cgl2612	0.0018
5293	Shikimate kinase 2	aroL	0.0018
5292	Putative partitioning protein	TT_C1605	0.0017
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0017
5266	Activator of	hgdC	0.0017
5291	Glycogen synthase 1	glgA1	0.0017
2874	Nitrogenase iron protein 1	nifH1	0.0017
4346	Polynucleotide kinase	pseT	0.0017
5264	DNA replication protein	REP	0.0017
5283	D-alanine--D-alanine ligase B	ddlB	0.0017
5281	Plasmid segregation protein parM	parM	0.0017
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0017
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0017
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0017
5299	D-alanine--D-alanine ligase	ddl	0.0017
6598	D-alanine--D-alanine ligase	ddl	0.0017
5284	Large T antigen	Not Available	0.0017
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0017
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0017
5277	Preprotein translocase subunit secA	secA	0.0017
5308	Preprotein translocase secA 1 subunit	secA1	0.0017
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0017
5285	Kinesin heavy chain	KIF5B	0.0017
5315	Chaperone protein htpG	htpG	0.0017
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0017
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0017
899	Glutathione S-transferase Mu 3	GSTM3	0.0017
905	Glutathione transferase omega-1	GSTO1	0.0017
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
4041	Microsomal glutathione S-transferase 2	MGST2	0.0017
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
1656	CYP2B protein	CYP2B	0.0017
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
2300	Lysozyme	E	0.0016
3633	Lysozyme	R	0.0016
5597	Lysozyme	17	0.0016
1243	Cathepsin D	CTSD	0.0016
1010	Cytochrome P450 51A1	CYP51A1	0.0016
2165	Glutathione S-transferase Mu 2	GSTM2	0.0016
474	Acetylcholinesterase	ACHE	0.0016
427	Substance-P receptor	TACR1	0.0016
2236	Casein kinase II subunit alpha	CSNK2A1	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0015
1275	Estrogen sulfotransferase	SULT1E1	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0015
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0015
4106	Guanylate kinase	GUK1	0.0015
4516	Guanylate kinase	gmk	0.0015
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0015
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0015
4774	NTPase P4	Not Available	0.0015
5646	Galactokinase	GALK1	0.0015
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0015
4837	Cag-alfa	cag-alfa	0.0015
5265	FtsH	ftsH	0.0015
4838	PMS1 protein homolog 2	PMS2	0.0015
5302	TrwB	trwB	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
4839	DNA polymerase III subunit tau	dnaX	0.0015
901	Glutathione S-transferase Mu 4	GSTM4	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
2270	Dephospho-CoA kinase	coaE	0.0015
5189	Trimethylamine dehydrogenase	tmd	0.0015
2284	Adenylate kinase	adk	0.0015
2296	Adenylate kinase	adk	0.0015
2311	Adenylate kinase	adk	0.0015
2312	Adenylate kinase	Not Available	0.0015
3470	Hypothetical protein MG245 homolog	MPN_348	0.0015
572	Integrin alpha-L	ITGAL	0.0015
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0015
3426	Glutamine synthetase	glnA	0.0015
3987	Glutamine synthetase	GLUL	0.0015
3175	Glutamate--cysteine ligase	gshA	0.0015
1050	Bile salt sulfotransferase	SULT2A1	0.0015
6432	Transporter	snf	0.0015
2599	Tyrosine-protein kinase HCK	HCK	0.0015
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0014
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
1353	DNA topoisomerase 1	TOP1	0.0014
3552	DNA topoisomerase 1	topA	0.0014
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0014
484	Tyrosine-protein kinase ABL2	ABL2	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0014
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0014
6859	Protein S100-A4	S100A4	0.0014
2683	Mono-ADP-ribosyltransferase C3	C3	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
847	Mu-type opioid receptor	OPRM1	0.0014
2390	Nonsecretory ribonuclease	RNASE2	0.0014
5312	Kinesin-like protein KIF1A	KIF1A	0.0014
2922	Glycerol kinase	glpK	0.0013
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
5271	Focal adhesion kinase 1	PTK2	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
2282	Protein recA	recA	0.0013
2315	Protein recA	recA	0.0013
2332	Protein recA	recA	0.0013
5263	Protein recA	recA	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
2615	Chemotaxis protein cheA	cheA	0.0013
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
2371	Pantothenate kinase	coaA	0.0013
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0013
1881	Hexokinase-1	HK1	0.0013
3669	Ribokinase	rbsK	0.0013
696	Kappa-type opioid receptor	OPRK1	0.0013
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0013
2892	Acetylglutamate kinase	argB	0.0013
3550	Acetylglutamate kinase	argB	0.0013
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
5300	Antigen peptide transporter 1	TAP1	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0012
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0012
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
518	Peroxidase/catalase T	katG	0.0012
2697	Uridine-cytidine kinase 2	UCK2	0.0012
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0012
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0012
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0012
788	Creatine kinase M-type	CKM	0.0012
2334	Dethiobiotin synthetase	bioD	0.0011
6555	Dethiobiotin synthetase	bioD	0.0011
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
828	Phenylalanine-4-hydroxylase	PAH	0.0011
3109	Phenylalanine-4-hydroxylase	phhA	0.0011
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0011
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
563	Thyroid peroxidase	TPO	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
84	Nuclear receptor 0B1	NR0B1	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0011
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
467	Delta-type opioid receptor	OPRD1	0.0011
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0011
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0011
2251	Thymidylate kinase	tmk	0.001
2254	Thymidylate kinase	DTYMK	0.001
3522	Thymidylate kinase	tmk	0.001
48	Pyridoxal kinase	PDXK	0.001
239	Coagulation factor X	F10	0.001
4237	50S ribosomal protein L22	rplV	0.001
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.001
469	Annexin A1	ANXA1	0.001
997	Protein kinase C beta type	PRKCB	0.001
1422	Serine/threonine-protein kinase 6	AURKA	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
3379	Kinesin-like protein KIF11	KIF11	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
825	Arsenical pump-driving ATPase	ASNA1	0.001
3435	Arsenical pump-driving ATPase	arsA	0.001
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.001
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.001
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.001
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.001
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.001
733	Activin receptor type 1B	ACVR1B	0.001
154	AFG3-like protein 2	AFG3L2	0.001
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.001
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.001
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.001
395	ALK tyrosine kinase receptor	Not Available	0.001
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.001
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.001
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.001
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
3822	Actin, alpha skeletal muscle	ACTA1	0.001
823	Fibroblast growth factor receptor 2	FGFR2	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
6182	Cytochrome P450 2J2	CYP2J2	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0009
292	Activin receptor type-1	ACVR1	0.0009
849	Activated CDC42 kinase 1	TNK2	0.0009
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0009
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0009
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0009
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0009
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0009
297	Adenylate cyclase type 1	ADCY1	0.0009
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0008
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
1618	High affinity nerve growth factor receptor	NTRK1	0.0008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
811	Translocator protein	TSPO	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
976	Platelet glycoprotein IX	GP9	0.0008
1374	Natriuretic peptides B	NPPB	0.0008
1827	Gap junction alpha-1 protein	GJA1	0.0008
1908	Vascular cell adhesion protein 1	VCAM1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
740	Argininosuccinate synthase	ASS1	0.0007
865	Argininosuccinate synthase	ASS1	0.0007
2680	Argininosuccinate synthase	argG	0.0007
3194	Argininosuccinate synthase	argG	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
6021	Adenosine kinase	ADK	0.0007
661	ADP/ATP translocase 1	SLC25A4	0.0007
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1864	RET proto-oncogene	RET	0.0006
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0006
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0006
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0006
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0006
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0006
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0006
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
153	Dopamine beta-hydroxylase	DBH	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
798	Osteocalcin	BGLAP	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
369	Coagulation factor VII	F7	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0005
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0004
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0004
164	Histamine H4 receptor	HRH4	0.0003
54	Prothrombin	F2	0.0003
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00300 - Tenofovir

Targets

Enzymes

Transporters

Predictions