DT-Web

DB00493 - Cefotaxime


Identification
Name Cefotaxime
Accession Number DB00493 (APRD00854)
Type small molecule
Description Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 455.465
Groups approved
Monoisotopic Weight 455.056939303
Pharmacology
Indication Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.
Mechanism of action The bactericidal activity of cefotaxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefotaxime shows high affinity for penicillin-binding proteins in the cell wall including PBP Ib and PBP III.
Absorption Rapidly absorbed following intramuscular injection.
Protein binding Not Available
Biotransformation Approximately 20-36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite. The desacetyl metabolite has been shown to contribute to the bactericidal activity. Two other urinary metabolites (M2 and M3) account for about 20-25%. They lack bactericidal activity.
Route of elimination Approximately 20-36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite.
Toxicity Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Oral rat LD50 is over 20,000 mg/kg while intravenous rat LD50 is over 7,000 mg/kg.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Kanamycin Increased risk of nephrotoxicity
Neomycin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Probenecid Probenecid may increase the serum level of cefotaxime.
Streptomycin Increased risk of nephrotoxicity
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


Penicillin-binding protein 1b
Name Penicillin-binding protein 1b
Gene Name pbp1b
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.1969
Penicillin-binding protein 2a
Name Penicillin-binding protein 2a
Gene Name pbp2a
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score Not Available
Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbpC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Selakovitch-Chenu L, Seroude L, Sicard AM: The role of penicillin-binding protein 3 (PBP 3) in cefotaxime resistance in Streptococcus pneumoniae. Mol Gen Genet. 1993 May;239(1-2):77-80. - Pubmed
  • Krauss J, Hakenbeck R: A mutation in the D,D-carboxypeptidase penicillin-binding protein 3 of Streptococcus pneumoniae contributes to cefotaxime resistance of the laboratory mutant C604. Antimicrob Agents Chemother. 1997 May;41(5):936-42. - Pubmed
  • Georgopapadakou NH, Smith SA, Cimarusti CM, Sykes RB: Binding of monobactams to penicillin-binding proteins of Escherichia coli and Staphylococcus aureus: relation to antibacterial activity. Antimicrob Agents Chemother. 1983 Jan;23(1):98-104. - Pubmed
DTHybrid score 0.4717
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.2071
Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0151

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.7539
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.7443
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.6386
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
DTHybrid score 0.4857
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
DTHybrid score 0.3567
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28;465(1-2):1-7. - Pubmed
DTHybrid score 0.2996

Predictions


Id Partner name Gene Name Score
6119 Penicillin-binding protein 3 pbp3 0.4717
7154 Penicillin-binding protein 3 pbp3 0.4717
7157 Penicillin-binding protein 3 LMHCC_2184 0.4717
7162 Penicillin-binding protein 3 pbpB 0.4717
7172 Penicillin-binding protein 3 pbp3 0.4717
118 Organic cation/carnitine transporter 2 SLC22A5 0.2449
633 Penicillin-binding proteins 1A/1B pbpA 0.2307
645 Penicillin-binding protein 1A mrcA 0.2071
5805 Penicillin-binding protein 1A ponA 0.2071
6185 Penicillin-binding protein 1A mrcA 0.2071
543 Penicillin-binding protein 1B mrcB 0.1969
6186 Penicillin-binding protein 1B ponB 0.1969
6822 Penicillin-binding protein 1b pbp1b 0.1969
244 Angiotensin-converting enzyme ACE 0.185
587 Serum albumin ALB 0.166
4512 Cytochrome P450 3A4 CYP3A4 0.1242
819 Penicillin-binding protein 4 dacB 0.1021
1 Peptidoglycan synthetase ftsI ftsI 0.0901
4155 Peptidoglycan synthetase ftsI ftsI 0.0901
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0878
1588 Multidrug resistance protein 1 ABCB1 0.0877
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0874
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0874
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0818
332 Beta-lactamase blaZ 0.0771
2478 Beta-lactamase ampC 0.0771
2613 Beta-lactamase ampC 0.0771
2635 Beta-lactamase ampC 0.0771
2700 Beta-lactamase penP 0.0771
5445 Beta-lactamase blaB 0.0771
6019 Beta-lactamase SHV-7 0.0771
6701 Beta-lactamase cphA 0.0771
4757 Cytochrome P450 2C9 CYP2C9 0.0746
738 Monocarboxylate transporter 1 SLC16A1 0.0697
2164 Multidrug resistance-associated protein 4 ABCC4 0.0679
20 Prostaglandin G/H synthase 1 PTGS1 0.0664
290 Prostaglandin G/H synthase 2 PTGS2 0.0648
4200 Cytochrome P450 1A2 CYP1A2 0.0564
6016 Cytochrome P450 2C19 CYP2C19 0.056
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0545
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0504
4924 Cytochrome P450 2C8 CYP2C8 0.0494
3760 Penicillin-binding protein 5 precursor dacA 0.0483
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0477
22 30S ribosomal protein S4 rpsD 0.0462
6714 30S ribosomal protein S4 rpsD 0.0462
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0457
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0451
140 30S ribosomal protein S9 rpsI 0.0435
6719 30S ribosomal protein S9 rpsI 0.0435
6725 30S ribosomal protein S9 rpsI 0.0435
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0418
6144 Solute carrier family 22 member 2 SLC22A2 0.0406
862 Multidrug resistance-associated protein 1 ABCC1 0.0403
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0397
6067 Penicillin binding protein 2a mecA 0.0395
4119 Cytochrome P450 2D6 CYP2D6 0.0395
6145 Solute carrier family 22 member 1 SLC22A1 0.0379
338 DNA polymerase UL30 0.0372
379 DNA polymerase UL54 0.0372
697 DNA polymerase ORF28 0.0372
2482 DNA polymerase 43 0.0372
4104 DNA polymerase BALF5 0.0372
3195 Beta-lactamase Toho-1 bla 0.0357
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0356
1385 Angiotensin-converting enzyme 2 ACE2 0.035
833 Organic cation/carnitine transporter 1 SLC22A4 0.031
6136 Multidrug resistance-associated protein 5 ABCC5 0.0306
776 Bile salt export pump ABCB11 0.0304
4118 Cytochrome P450 3A5 CYP3A5 0.0303
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.03
1757 Myeloperoxidase MPO 0.0296
3426 Glutamine synthetase glnA 0.029
3987 Glutamine synthetase GLUL 0.029
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0289
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0285
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0282
6141 Sodium/bile acid cotransporter SLC10A1 0.0276
5353 Glutamate decarboxylase alpha gadA 0.027
4604 Liver carboxylesterase 1 CES1 0.0268
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0268
3917 Methylenetetrahydrofolate reductase MTHFR 0.0265
438 Taste receptor type 1 member 2 TAS1R2 0.0248
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0246
234 Plasminogen PLG 0.0246
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0241
115 Penicillin-binding protein 2 mrdA 0.0235
6069 Penicillin-binding protein 2 mrdA 0.0235
6118 Penicillin-binding protein 2 penA 0.0235
6187 Penicillin-binding protein 2 pbpA 0.0235
6686 Penicillin-binding protein 2 pbp2 0.0235
6939 Penicillin-binding protein 2 mrdA 0.0235
7163 Penicillin-binding protein 2 pbpA 0.0235
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
6107 Cytochrome P450 3A7 CYP3A7 0.0227
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0226
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0216
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0216
6149 Solute carrier family 22 member 10 SLC22A10 0.021
1867 Major prion protein PRNP 0.0208
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
3923 Cholinesterase BCHE 0.0203
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
6020 Aldehyde oxidase AOX1 0.02
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
558 Solute carrier family 12 member 1 SLC12A1 0.0196
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
6207 30S ribosomal protein S14 rpsN 0.0179
6209 30S ribosomal protein S19 rpsS 0.0179
6712 30S ribosomal protein S19 rpsS 0.0179
6726 30S ribosomal protein S19 rpsS 0.0179
6024 Cytochrome P450 1A1 CYP1A1 0.0174
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
357 Carbonic anhydrase 2 CA2 0.017
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
3947 Xanthine dehydrogenase/oxidase XDH 0.0163
509 Thymidine kinase TK 0.0161
570 Thymidine kinase TK 0.0161
2559 Thymidine kinase TK 0.0161
3430 Thymidine kinase tdk 0.0161
3518 Thymidine kinase TK 0.0161
5301 Thymidine kinase tdk 0.0161
5771 Thymidine kinase ORF36 0.0161
7009 Thymidine kinase ORF36 0.0161
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0158
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0158
6147 Solute carrier family 22 member 3 SLC22A3 0.0155
6033 High affinity interleukin-8 receptor A CXCR1 0.0154
527 Prostacyclin receptor PTGIR 0.0152
65 Matrix metalloproteinase-9 Not Available 0.0151
159 Penicillin-binding protein 2B penA 0.0151
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.015
295 Carbonic anhydrase 1 CA1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
672 Prostaglandin F2-alpha receptor PTGFR 0.0148
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0146
4252 Penicillin-binding protein 5 dacA 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
6148 Multidrug resistance-associated protein 7 ABCC10 0.0138
1654 Interleukin-1 beta IL1B 0.0137
275 Arachidonate 5-lipoxygenase ALOX5 0.0135
6106 Cytochrome P450 2C18 CYP2C18 0.013
6167 Organic solute transporter subunit beta OSTB 0.013
6166 Organic solute transporter subunit alpha OSTA 0.013
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0128
3685 Catabolite gene activator crp 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
6013 Cytochrome P450 2E1 CYP2E1 0.0127
5626 Nucleoside diphosphate kinase B NME2 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
2320 Thymidine kinase, cytosolic TK1 0.0126
130 Prostacyclin synthase PTGIS 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
124 Histamine H2 receptor HRH2 0.0121
3810 Catechol O-methyltransferase COMT 0.012
5718 Cytochrome P450 2A6 CYP2A6 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
1141 Sialidase-1 NEU1 0.0117
64 Neuraminidase NA 0.0117
641 Neuraminidase NA 0.0117
2676 Neuraminidase NA 0.0117
3026 Neuraminidase NA 0.0117
3519 Neuraminidase NA 0.0117
6007 Neuraminidase NA 0.0117
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0115
494 Caspase-1 CASP1 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
183 Vascular endothelial growth factor A VEGFA 0.011
4760 Mll3241 protein mll3241 0.0109
1507 Cytochrome c CYCS 0.0105
6126 Carbonic anhydrase 7 CA7 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0102
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
4217 Telomerase reverse transcriptase TERT 0.0101
6030 Cytochrome P450 2B6 CYP2B6 0.0097
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0097
1405 Thiopurine S-methyltransferase TPMT 0.0097
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2077 Caspase-3 CASP3 0.0093
5482 Sialidase-2 NEU2 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6031 Cytochrome P450 3A43 CYP3A43 0.0089
24 Thymidylate synthase TMP1 0.0089
359 Thymidylate synthase TYMS 0.0089
2626 Thymidylate synthase thyA 0.0089
2729 Thymidylate synthase thyA 0.0089
5352 Thymidylate synthase THYA 0.0089
4122 Histone deacetylase 2 HDAC2 0.0087
3811 Cytochrome P450 19A1 CYP19A1 0.0085
373 Transthyretin TTR 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6137 Multidrug resistance-associated protein 6 ABCC6 0.0083
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0083
16 Adenosine A1 receptor ADORA1 0.008
1898 Cytochrome P450 1B1 CYP1B1 0.008
1178 Adenosine A2a receptor ADORA2A 0.0078
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0078
6043 Putative G-protein coupled receptor 44 GPR44 0.0076
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0075
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0075
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
707 72 kDa type IV collagenase MMP2 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
293 Gamma-glutamyl hydrolase GGH 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
2981 Phospholipase A2, membrane associated PLA2G2A 0.0071
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0071
318 Alpha-2A adrenergic receptor ADRA2A 0.0071
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0071
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.007
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
756 Sex hormone-binding globulin SHBG 0.0068
6218 Pannexin-1 PANX1 0.0068
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
273 Apoptosis regulator Bcl-2 BCL2 0.0065
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0065
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0065
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
4773 Deoxycytidine kinase DCK 0.0064
1650 Heme carrier protein 1 SLC46A1 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0061
5818 Folate receptor alpha FOLR1 0.0061
6042 Prostaglandin reductase 2 PTGR2 0.006
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.006
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.006
146 Androgen receptor AR 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
6085 Fatty acid-binding protein, intestinal FABP2 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
632 Alpha-1B adrenergic receptor ADRA1B 0.0056
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0055
2021 Thrombomodulin THBD 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0053
818 50S ribosomal protein L10 rplJ 0.0053
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
4238 50S ribosomal protein L4 rplD 0.0052
5578 50S ribosomal protein L4 rplD 0.0052
6173 50S ribosomal protein L4 rplD 0.0052
6219 50S ribosomal protein L4 rplD 0.0052
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
556 Alpha-1A adrenergic receptor ADRA1A 0.005
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
4237 50S ribosomal protein L22 rplV 0.0047
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0047
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0047
1313 Lactoylglutathione lyase GLO1 0.0046
136 Estrogen receptor ESR1 0.0046
1039 Histone deacetylase 9 HDAC9 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0045
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0044
489 Monocarboxylate transporter 2 SLC16A7 0.0044
3587 Gastrotropin FABP6 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
6151 Monocarboxylate transporter 10 SLC16A10 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0041
408 Riboflavin kinase RFK 0.0041
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
3941 Amine oxidase [flavin-containing] A MAOA 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
1792 Tissue-type plasminogen activator PLAT 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
492 Histamine H1 receptor HRH1 0.0035
997 Protein kinase C beta type PRKCB 0.0035
594 Thyroxine-binding globulin SERPINA7 0.0034
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
5924 Microtubule-associated protein 4 MAP4 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
4225 Uridine phosphorylase 1 UPP1 0.003
1852 Microtubule-associated protein 2 MAP2 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
654 Flavin reductase BLVRB 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
346 Thyroid hormone receptor beta-1 THRB 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
5126 Arginase rocF 0.0027
1025 Aquaporin-1 AQP1 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0026
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0026
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0026
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
163 D(1B) dopamine receptor DRD5 0.0024
2540 Choloylglycine hydrolase cbh 0.0023
432 D(4) dopamine receptor DRD4 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0022
638 D(3) dopamine receptor DRD3 0.0022
6501 Fatty acid-binding protein, liver FABP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
23 D(1A) dopamine receptor DRD1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
3957 Adenosine deaminase ADA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
831 D(2) dopamine receptor DRD2 0.0018
6500 Phospholipase A2 PLA2G1B 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0017
5773 DNA-directed RNA polymerase beta chain rpoB 0.0017
869 Estrogen receptor beta ESR2 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
33 Cystine/glutamate transporter SLC7A11 0.0016
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0007
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