DT-Web

DB00642 - Pemetrexed


Identification
Name Pemetrexed
Accession Number DB00642 (APRD00573, EXPT02075)
Type small molecule
Description Pemetrexed (brand name Alimta(R)) is a chemotherapy drug manufactured and marketed by Eli Lilly and Company. Its indications are the treatment of pleural mesothelioma as well as non-small cell lung cancer.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 427.4106
Groups approved
Monoisotopic Weight 427.149183429
Pharmacology
Indication Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Mechanism of action Pemetrexed is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antineoplastic activity by disrupting folate-dependent metabolic processes essential for cell replication. In vitro studies have shown that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), all folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides. Pemetrexed is transported into cells by both the reduced folate carrier and membrane folate binding protein transport systems. Once in the cell, pemetrexed is converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT. Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, to a lesser extent, in normal tissues. Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells.
Absorption Not Available
Protein binding 81%
Biotransformation Metabolized by Cytochrome P450 Enzymes
Route of elimination Pemetrexed is not metabolized to an appreciable extent and is primarily eliminated in the urine, with 70% to 90% of the dose recovered unchanged within the first 24 hours following administration.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ketoprofen The NSAID, ketoprofen, may increase increase the serum concentration of pemetrexed by decreasing its renal clearance. Patients with mild to moderate renal insufficiency (CrCl 45-79 ml/min) should avoid use of ketoprofen within 2 days of a pemetrexed dose. Patients with better renal function do not appear to be at risk. Monitor for toxicity in all patients during concomitant therapy.
Sulindac The NSAID, sulindac, may increase the serum concentration of pemetrexed by decreasing its elimination. This interaction more prevalent in patients with mild to moderate renal insufficiency. Consider alternate therapy or monitor for pemetrexed toxicity during concomitant therapy.
Tiaprofenic acid Tiaprofenic acid may decrease Pemetrexed excretion. Tiaprofenic acid should not be used around the time when Pemetrexed is administered.
Tolmetin Tolmetin may decrease the renal excretion of Pemetrexed in patients with decreased creatinine clearance. Tolmetin may be withheld in these patients from 2 days before to 2 days after Pemetrexed administration.
Food Interactions Not Available

Targets


Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Pharmacological action yes
Actions inhibitor
References
  • Adjei AA: Gemcitabine and Pemetrexed disodium in treating breast cancer. Oncology (Williston Park). 2001 Feb;15(2 Suppl 3):34-7. - Pubmed
  • Hanauske AR, Chen V, Paoletti P, Niyikiza C: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist. 2001;6(4):363-73. - Pubmed
  • Pivot X, Raymond E, Laguerre B, Degardin M, Cals L, Armand JP, Lefebvre JL, Gedouin D, Ripoche V, Kayitalire L, Niyikiza C, Johnson R, Latz J, Schneider M: Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br J Cancer. 2001 Sep 1;85(5):649-55. - Pubmed
  • Adjei AA: Gemcitabine and pemetrexed disodium combinations in vitro and in vivo. Lung Cancer. 2001 Dec;34 Suppl 4:S103-5. - Pubmed
  • Norman P: Pemetrexed disodium (Eli Lilly). Curr Opin Investig Drugs. 2001 Nov;2(11):1611-22. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Schultz RM, Dempsey JA: Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells. Anticancer Res. 2001 Sep-Oct;21(5):3209-14. - Pubmed
  • Adjei AA: Pemetrexed in the treatment of selected solid tumors. Semin Oncol. 2002 Apr;29(2 Suppl 5):50-3. - Pubmed
  • Molina JR, Adjei AA: The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy. Clin Lung Cancer. 2003 Jul;5(1):21-7. - Pubmed
  • Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M, Danesi R: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol. 2005 Jul;68(1):110-8. Epub 2005 Mar 28. - Pubmed
  • Kindler HL: Pemetrexed in pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 18):49-53. - Pubmed
DTHybrid score 0.7442
Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Name Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name ATIC
Pharmacological action yes
Actions inhibitor
References
  • Kindler HL: Pemetrexed in pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 18):49-53. - Pubmed
  • Hanauske AR, Chen V, Paoletti P, Niyikiza C: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist. 2001;6(4):363-73. - Pubmed
  • Racanelli AC, Rothbart SB, Heyer CL, Moran RG: Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. Cancer Res. 2009 Jul 1;69(13):5467-74. Epub 2009 Jun 23. - Pubmed
DTHybrid score 0.9358
Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name DHFR
Pharmacological action yes
Actions inhibitor
References
  • Hanauske AR, Chen V, Paoletti P, Niyikiza C: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist. 2001;6(4):363-73. - Pubmed
  • Norman P: Pemetrexed disodium (Eli Lilly). Curr Opin Investig Drugs. 2001 Nov;2(11):1611-22. - Pubmed
  • Mauritz R, Peters GJ, Priest DG, Assaraf YG, Drori S, Kathmann I, Noordhuis P, Bunni MA, Rosowsky A, Schornagel JH, Pinedo HM, Jansen G: Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochem Pharmacol. 2002 Jan 15;63(2):105-15. - Pubmed
  • Schultz RM, Dempsey JA: Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells. Anticancer Res. 2001 Sep-Oct;21(5):3209-14. - Pubmed
  • Adjei AA: Pemetrexed in the treatment of selected solid tumors. Semin Oncol. 2002 Apr;29(2 Suppl 5):50-3. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Adjei AA: Gemcitabine and Pemetrexed disodium in treating breast cancer. Oncology (Williston Park). 2001 Feb;15(2 Suppl 3):34-7. - Pubmed
  • Pivot X, Raymond E, Laguerre B, Degardin M, Cals L, Armand JP, Lefebvre JL, Gedouin D, Ripoche V, Kayitalire L, Niyikiza C, Johnson R, Latz J, Schneider M: Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br J Cancer. 2001 Sep 1;85(5):649-55. - Pubmed
  • Adjei AA: Gemcitabine and pemetrexed disodium combinations in vitro and in vivo. Lung Cancer. 2001 Dec;34 Suppl 4:S103-5. - Pubmed
  • Molina JR, Adjei AA: The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy. Clin Lung Cancer. 2003 Jul;5(1):21-7. - Pubmed
  • Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M, Danesi R: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol. 2005 Jul;68(1):110-8. Epub 2005 Mar 28. - Pubmed
  • Kindler HL: Pemetrexed in pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 18):49-53. - Pubmed
DTHybrid score 1.2014
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase
Name Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase
Gene Name GART
Pharmacological action yes
Actions inhibitor
References
  • Schultz RM, Dempsey JA: Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells. Anticancer Res. 2001 Sep-Oct;21(5):3209-14. - Pubmed
  • Hanauske AR, Chen V, Paoletti P, Niyikiza C: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist. 2001;6(4):363-73. - Pubmed
  • Molina JR, Adjei AA: The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy. Clin Lung Cancer. 2003 Jul;5(1):21-7. - Pubmed
  • Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M, Danesi R: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol. 2005 Jul;68(1):110-8. Epub 2005 Mar 28. - Pubmed
  • Kindler HL: Pemetrexed in pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 18):49-53. - Pubmed
  • Adjei AA: Gemcitabine and Pemetrexed disodium in treating breast cancer. Oncology (Williston Park). 2001 Feb;15(2 Suppl 3):34-7. - Pubmed
  • Pivot X, Raymond E, Laguerre B, Degardin M, Cals L, Armand JP, Lefebvre JL, Gedouin D, Ripoche V, Kayitalire L, Niyikiza C, Johnson R, Latz J, Schneider M: Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br J Cancer. 2001 Sep 1;85(5):649-55. - Pubmed
  • Adjei AA: Gemcitabine and pemetrexed disodium combinations in vitro and in vivo. Lung Cancer. 2001 Dec;34 Suppl 4:S103-5. - Pubmed
  • Adjei AA: Pemetrexed in the treatment of selected solid tumors. Semin Oncol. 2002 Apr;29(2 Suppl 5):50-3. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9899

Enzymes


Deoxycytidine kinase
Name Deoxycytidine kinase
Gene Name DCK
Actions inducer
References
  • -
  • De Pas TM, Toffalorio F, Giovannetti E, Radice D, Russo F, Angeli I, Calamai G, Spitaleri G, Catania C, Noberasco C, Milani A, Pelosi G, Danesi R, De Braud F: Optimizing pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer: a pharmacogenetic approach. J Thorac Oncol. 2011 Apr;6(4):768-73. - Pubmed
DTHybrid score 0.6261
Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions inducer
References
  • De Pas TM, Toffalorio F, Giovannetti E, Radice D, Russo F, Angeli I, Calamai G, Spitaleri G, Catania C, Noberasco C, Milani A, Pelosi G, Danesi R, De Braud F: Optimizing pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer: a pharmacogenetic approach. J Thorac Oncol. 2011 Apr;6(4):768-73. - Pubmed
DTHybrid score 0.4362

Predictions


Id Partner name Gene Name Score
2381 Dihydrofolate reductase DFR1 1.2014
2833 Dihydrofolate reductase Not Available 1.2014
2931 Dihydrofolate reductase folA 1.2014
3544 Dihydrofolate reductase folA 1.2014
3682 Dihydrofolate reductase folA 1.2014
6642 Dihydrofolate reductase folA 1.2014
6756 Dihydrofolate reductase dfrA 1.2014
24 Thymidylate synthase TMP1 0.7442
2626 Thymidylate synthase thyA 0.7442
2729 Thymidylate synthase thyA 0.7442
5352 Thymidylate synthase THYA 0.7442
2689 Phosphoribosylglycinamide formyltransferase purN 0.1637
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.1483
603 DNA polymerase alpha catalytic subunit POLA1 0.1348
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.1291
6171 Solute carrier family 28 member 3 SLC28A3 0.1237
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.1037
6236 Trimethoprim-sensitive dihydrofolate reductase dfrB 0.0961
3690 Class B acid phosphatase precursor aphA 0.0952
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0934
3639 Thymidine phosphorylase deoA 0.0854
3936 Thymidine phosphorylase TYMP 0.0854
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.085
3611 Cytidine deaminase cdd 0.0825
3707 Cytidine deaminase cdd 0.0825
4211 Cytidine deaminase CDA 0.0825
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0636
6148 Multidrug resistance-associated protein 7 ABCC10 0.0547
1729 Solute carrier family 22 member 6 SLC22A6 0.0516
702 UMP-CMP kinase CMPK1 0.0464
6083 Deoxyguanosine kinase, mitochondrial DGUOK 0.0461
1650 Heme carrier protein 1 SLC46A1 0.0435
1124 Sepiapterin reductase SPR 0.0413
4757 Cytochrome P450 2C9 CYP2C9 0.0405
277 Purine nucleoside phosphorylase PNP 0.0395
2870 Purine nucleoside phosphorylase punA 0.0395
2945 Purine nucleoside phosphorylase punA 0.0395
4659 Purine nucleoside phosphorylase TM_1596 0.0395
4825 Purine nucleoside phosphorylase TTHA1435 0.0395
2164 Multidrug resistance-associated protein 4 ABCC4 0.0391
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0348
1830 5'-nucleotidase NT5E 0.0338
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0326
1588 Multidrug resistance protein 1 ABCB1 0.0318
4512 Cytochrome P450 3A4 CYP3A4 0.0316
125 DNA polymerase beta POLB 0.0316
6143 Solute carrier family 22 member 7 SLC22A7 0.0284
3917 Methylenetetrahydrofolate reductase MTHFR 0.0253
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0251
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0242
6144 Solute carrier family 22 member 2 SLC22A2 0.0239
4924 Cytochrome P450 2C8 CYP2C8 0.0237
2320 Thymidine kinase, cytosolic TK1 0.0231
6145 Solute carrier family 22 member 1 SLC22A1 0.0229
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0227
752 Large structural protein L 0.0227
3957 Adenosine deaminase ADA 0.022
4106 Guanylate kinase GUK1 0.0219
4516 Guanylate kinase gmk 0.0219
2361 Response regulator pleD pleD 0.0216
2516 GMP reductase 1 GMPR 0.0216
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.02
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0196
6031 Cytochrome P450 3A43 CYP3A43 0.019
6136 Multidrug resistance-associated protein 5 ABCC5 0.019
6020 Aldehyde oxidase AOX1 0.0189
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0185
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0179
4119 Cytochrome P450 2D6 CYP2D6 0.0176
338 DNA polymerase UL30 0.0173
379 DNA polymerase UL54 0.0173
697 DNA polymerase ORF28 0.0173
2482 DNA polymerase 43 0.0173
4104 DNA polymerase BALF5 0.0173
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0172
3300 Xanthine phosphoribosyltransferase xpt 0.0163
3681 Xanthine phosphoribosyltransferase gpt 0.0163
6021 Adenosine kinase ADK 0.0159
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0157
4226 Uridine phosphorylase 2 UPP2 0.0155
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0152
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0149
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0147
4225 Uridine phosphorylase 1 UPP1 0.0144
5818 Folate receptor alpha FOLR1 0.0142
6107 Cytochrome P450 3A7 CYP3A7 0.014
4118 Cytochrome P450 3A5 CYP3A5 0.0132
6111 DNA polymerase epsilon subunit 4 POLE4 0.0131
6112 DNA polymerase epsilon subunit 3 POLE3 0.0131
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0131
6110 DNA polymerase epsilon subunit 2 POLE2 0.0131
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0131
6142 Solute carrier family 22 member 8 SLC22A8 0.0131
2567 Thymidylate synthase thyX thyX 0.0128
413 Amidophosphoribosyltransferase PPAT 0.0128
2515 Amidophosphoribosyltransferase purF 0.0128
3714 Amidophosphoribosyltransferase purF 0.0128
4275 PCZA361.16 Not Available 0.0128
4276 DNA polymerase III subunit epsilon dnaQ 0.0128
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
293 Gamma-glutamyl hydrolase GGH 0.0123
1405 Thiopurine S-methyltransferase TPMT 0.0123
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0122
3763 5,10-methylenetetrahydrofolate reductase metF 0.0122
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0122
5094 5,10-methylenetetrahydrofolate reductase metF 0.0122
59 AMT protein AMT 0.0122
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0122
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0122
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0116
2555 Pol polyprotein pol 0.0114
3242 Pol polyprotein gag-pol 0.0114
3471 Pol polyprotein gag-pro-pol 0.0114
5256 Pol polyprotein pol 0.0114
6469 Pol polyprotein gag-pol 0.0114
6565 Pol polyprotein Not Available 0.0114
1353 DNA topoisomerase 1 TOP1 0.0114
3552 DNA topoisomerase 1 topA 0.0114
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0113
13 Aminomethyltransferase, mitochondrial AMT 0.0111
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0108
587 Serum albumin ALB 0.0107
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0102
4604 Liver carboxylesterase 1 CES1 0.0101
862 Multidrug resistance-associated protein 1 ABCC1 0.01
3947 Xanthine dehydrogenase/oxidase XDH 0.0099
342 P protein [Includes: DNA-directed DNA polymerase P 0.0099
612 P protein [Includes: DNA-directed DNA polymerase P 0.0099
2251 Thymidylate kinase tmk 0.0098
2254 Thymidylate kinase DTYMK 0.0098
3522 Thymidylate kinase tmk 0.0098
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0097
509 Thymidine kinase TK 0.0094
570 Thymidine kinase TK 0.0094
2559 Thymidine kinase TK 0.0094
3430 Thymidine kinase tdk 0.0094
3518 Thymidine kinase TK 0.0094
5301 Thymidine kinase tdk 0.0094
5771 Thymidine kinase ORF36 0.0094
7009 Thymidine kinase ORF36 0.0094
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0094
3884 SHMT2 protein SHMT2 0.0089
3901 SHMT2 protein SHMT2 0.0089
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0089
3879 Serine hydroxymethyltransferase 2 Not Available 0.0089
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0089
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0089
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0088
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0088
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0087
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0085
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0084
3361 Serpin B5 SERPINB5 0.0084
5694 Transcription antiterminator licT licT 0.0084
809 Methionine synthase MTR 0.0083
2935 Methionine synthase metH 0.0083
4200 Cytochrome P450 1A2 CYP1A2 0.0082
5626 Nucleoside diphosphate kinase B NME2 0.0079
738 Monocarboxylate transporter 1 SLC16A1 0.0077
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0075
5294 Nucleoside diphosphate kinase A NME1 0.007
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.007
267 Plasminogen activator inhibitor 1 SERPINE1 0.0067
56 Delta-aminolevulinic acid dehydratase ALAD 0.0067
2356 Delta-aminolevulinic acid dehydratase hemB 0.0067
3613 Delta-aminolevulinic acid dehydratase hemB 0.0067
3674 Delta-aminolevulinic acid dehydratase hemB 0.0067
1024 Solute carrier family 22 member 11 SLC22A11 0.0064
5718 Cytochrome P450 2A6 CYP2A6 0.0062
4534 Cytohesin-2 CYTH2 0.0061
6221 Steroid hormone receptor ERR1 ESRRA 0.0059
3668 Maltose-binding periplasmic protein precursor malE 0.0059
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0058
6016 Cytochrome P450 2C19 CYP2C19 0.0055
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0054
2592 Beta-galactosidase lacZ 0.0053
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0052
315 Arginase-1 ARG1 0.005
6147 Solute carrier family 22 member 3 SLC22A3 0.0046
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0046
3809 Estrogen-related receptor gamma ESRRG 0.0045
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0045
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0045
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.004
6013 Cytochrome P450 2E1 CYP2E1 0.0037
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0036
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0034
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0033
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0033
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0032
776 Bile salt export pump ABCB11 0.0032
3811 Cytochrome P450 19A1 CYP19A1 0.0032
6024 Cytochrome P450 1A1 CYP1A1 0.0027
6030 Cytochrome P450 2B6 CYP2B6 0.0025
5287 Signaling protein Not Available 0.0021
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0021
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0021
5288 Shikimate kinase aroK 0.0021
5304 UPF0166 protein TM_0021 TM_0021 0.0021
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0021
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0021
5259 Transcriptional regulator ntrC1 0.0021
6699 Transcriptional regulator Cgl2612 0.0021
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0021
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0021
3199 Phosphopantetheine adenylyltransferase coaD 0.0021
3543 Phosphopantetheine adenylyltransferase coaD 0.0021
3567 Phosphopantetheine adenylyltransferase coaD 0.0021
5289 Phosphopantetheine adenylyltransferase coaD 0.0021
2874 Nitrogenase iron protein 1 nifH1 0.0021
4346 Polynucleotide kinase pseT 0.0021
5293 Shikimate kinase 2 aroL 0.0021
5292 Putative partitioning protein TT_C1605 0.0021
5281 Plasmid segregation protein parM parM 0.0021
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0021
5299 D-alanine--D-alanine ligase ddl 0.0021
6598 D-alanine--D-alanine ligase ddl 0.0021
5276 Chromosomal replication initiator protein dnaA dnaA 0.0021
5266 Activator of hgdC 0.0021
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0021
5283 D-alanine--D-alanine ligase B ddlB 0.0021
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0021
5308 Preprotein translocase secA 1 subunit secA1 0.0021
5315 Chaperone protein htpG htpG 0.0021
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0021
5284 Large T antigen Not Available 0.0021
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0021
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0021
5261 Phosphoribosylformylglycinamidine synthase purL 0.0021
5277 Preprotein translocase subunit secA secA 0.0021
5291 Glycogen synthase 1 glgA1 0.0021
5264 DNA replication protein REP 0.0021
5285 Kinesin heavy chain KIF5B 0.0021
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0019
666 NADP-dependent malic enzyme ME1 0.0019
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0018
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0018
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0018
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0018
5332 MtdA bifunctional protein mtdA 0.0018
4403 Protein iolS iolS 0.0018
5322 Oxidoreductase ydhF ydhF 0.0018
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0018
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0018
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0018
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0018
5330 General stress protein 69 yhdN 0.0018
3778 NAD(P) transhydrogenase subunit beta pntB 0.0018
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0017
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
6277 Heat shock cognate 71 kDa protein HSPA8 0.0016
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0016
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0016
4837 Cag-alfa cag-alfa 0.0016
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0016
5646 Galactokinase GALK1 0.0016
5302 TrwB trwB 0.0016
4839 DNA polymerase III subunit tau dnaX 0.0016
4774 NTPase P4 Not Available 0.0016
4838 PMS1 protein homolog 2 PMS2 0.0016
5265 FtsH ftsH 0.0016
4582 Putative pteridine reductase 2 ptr2 0.0016
340 Apoptotic protease-activating factor 1 APAF1 0.0016
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0016
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0016
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0016
5073 Ferredoxin--NADP reductase petH 0.0016
5076 Ferredoxin--NADP reductase fpr 0.0016
5119 Ferredoxin--NADP reductase petH 0.0016
5121 Ferredoxin--NADP reductase fpr 0.0016
5328 Prostaglandin F synthase Tb11.02.2310 0.0016
989 L-xylulose reductase DCXR 0.0016
3446 NADP-dependent alcohol dehydrogenase adh 0.0016
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0016
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0016
2636 Shikimate dehydrogenase aroE 0.0016
3515 Shikimate dehydrogenase aroE 0.0016
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0016
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0016
2286 Isocitrate dehydrogenase [NADP] icd 0.0016
2302 Isocitrate dehydrogenase [NADP] icd 0.0016
2771 Isocitrate dehydrogenase [NADP] icd 0.0016
654 Flavin reductase BLVRB 0.0016
2270 Dephospho-CoA kinase coaE 0.0016
5189 Trimethylamine dehydrogenase tmd 0.0016
2284 Adenylate kinase adk 0.0016
2296 Adenylate kinase adk 0.0016
2311 Adenylate kinase adk 0.0016
2312 Adenylate kinase Not Available 0.0016
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0015
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
3470 Hypothetical protein MG245 homolog MPN_348 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
3175 Glutamate--cysteine ligase gshA 0.0015
3426 Glutamine synthetase glnA 0.0015
3987 Glutamine synthetase GLUL 0.0015
5300 Antigen peptide transporter 1 TAP1 0.0015
2683 Mono-ADP-ribosyltransferase C3 C3 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0015
6297 Prostaglandin reductase 1 PTGR1 0.0015
4531 Putative ketoacyl reductase actIII 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
3062 Aspartate-semialdehyde dehydrogenase asd 0.0014
2390 Nonsecretory ribonuclease RNASE2 0.0014
5312 Kinesin-like protein KIF1A KIF1A 0.0014
2282 Protein recA recA 0.0014
2315 Protein recA recA 0.0014
2332 Protein recA recA 0.0014
5263 Protein recA recA 0.0014
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
2922 Glycerol kinase glpK 0.0014
2675 Pteridine reductase 1 PTR1 0.0014
408 Riboflavin kinase RFK 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0014
2159 Quinone oxidoreductase CRYZ 0.0013
5271 Focal adhesion kinase 1 PTK2 0.0013
2615 Chemotaxis protein cheA cheA 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0013
1881 Hexokinase-1 HK1 0.0013
2371 Pantothenate kinase coaA 0.0013
822 Aldose reductase AKR1B1 0.0013
3669 Ribokinase rbsK 0.0013
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0012
2892 Acetylglutamate kinase argB 0.0012
3550 Acetylglutamate kinase argB 0.0012
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0012
825 Arsenical pump-driving ATPase ASNA1 0.0012
3435 Arsenical pump-driving ATPase arsA 0.0012
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0012
2697 Uridine-cytidine kinase 2 UCK2 0.0012
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0012
2727 S-adenosylmethionine synthetase metK 0.0012
788 Creatine kinase M-type CKM 0.0011
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0011
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0011
48 Pyridoxal kinase PDXK 0.0011
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
2091 Endoplasmin HSP90B1 0.001
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.001
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.001
6395 Myosin-14 MYH14 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
504 Mast/stem cell growth factor receptor KIT 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0009
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0009
4120 NADPH--cytochrome P450 reductase POR 0.0009
3822 Actin, alpha skeletal muscle ACTA1 0.0009
5682 Ribonuclease pancreatic RNASE1 0.0008
1721 Glycogen synthase kinase-3 beta GSK3B 0.0008
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0007
816 Biliverdin reductase A BLVRA 0.0006
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0006
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0006
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0006
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0005
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0005
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0005
328 Sorbitol dehydrogenase SORD 0.0005
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0005
597 Dihydropteridine reductase QDPR 0.0005
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0005
396 Alcohol dehydrogenase 4 ADH4 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0005
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0005
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0005
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0005
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0005
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0005
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0005
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0005
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0005
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0005
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0005
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0005
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0005
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0005
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0005
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0005
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0005
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0005
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0005
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0005
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0005
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0005
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0005
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0005
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0005
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0005
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0005
107 C-4 methylsterol oxidase SC4MOL 0.0005
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0005
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0005
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0005
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0005
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0005
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0005
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0005
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0005
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0005
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0005
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0005
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0005
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0005
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0005
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0005
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0005
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0005
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0005
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0005
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0005
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0005
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0005
3726 D-3-phosphoglycerate dehydrogenase serA 0.0005
4291 D-3-phosphoglycerate dehydrogenase serA 0.0005
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0005
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0005
729 GDP-L-fucose synthetase TSTA3 0.0005
3463 GDP-L-fucose synthetase fcl 0.0005
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0005
167 L-lactate dehydrogenase C chain LDHC 0.0005
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0005
206 3-keto-steroid reductase HSD17B7 0.0005
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0005
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0005
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0005
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0005
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0005
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0005
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0005
643 Peroxisomal bifunctional enzyme EHHADH 0.0005
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0005
34 7-dehydrocholesterol reductase DHCR7 0.0005
711 UDP-glucose 6-dehydrogenase UGDH 0.0005
3672 UDP-glucose 6-dehydrogenase hasB 0.0005
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0005
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0005
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0005
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
473 L-lactate dehydrogenase A chain LDHA 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0004
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0004
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
626 Cysteine dioxygenase type 1 CDO1 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
611 Retinal dehydrogenase 1 ALDH1A1 0.0004
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0004
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0004
627 11-cis retinol dehydrogenase RDH5 0.0004
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0004
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0004
569 Retinal dehydrogenase 2 ALDH1A2 0.0004
714 Glutathione reductase, mitochondrial GSR 0.0004
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0004
380 Cytochrome P450 17A1 CYP17A1 0.0004
279 Tyrosinase TYR 0.0004
517 Alcohol dehydrogenase 1C ADH1C 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0004
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0003
468 Cytochrome P450 4A11 CYP4A11 0.0003
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