DT-Web

DB00738 - Pentamidine


Identification
Name Pentamidine
Accession Number DB00738 (APRD00303, EXPT02625)
Type small molecule
Description Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 340.4195
Groups approved
Monoisotopic Weight 340.189926032
Pharmacology
Indication For the treatment of pneumonia due to Pneumocystis carinii.
Mechanism of action The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Absorption Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
Protein binding 69%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
Affected organisms
  • Pneumocystis carinii
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Quinupristin This combination presents an increased risk of toxicity
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Pentamidine. Consider alternate therapy or monitor for adverse/toxic effects of Pentamidine if Ticlopidine is initiated, discontinued or dose changed.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Zalcitabine Additive risk of pancreatitis. Concomitant therapy should be avoided.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action unknown
Actions intercalation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Shankar SM, Nania JJ: Management of Pneumocystis jiroveci Pneumonia in Children Receiving Chemotherapy. Paediatr Drugs. 2007;9(5):301-9. - Pubmed
DTHybrid score Not Available
tRNA
Name tRNA
Gene Name TRDMT1
Pharmacological action unknown
Actions other
References
  • Sun T, Zhang Y: Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation. Nucleic Acids Res. 2008 Mar;36(5):1654-64. Epub 2008 Feb 7. - Pubmed
DTHybrid score 0.1287

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • -
  • Afrin LB, Afrin JB: Value of preemptive CYP2C19 genotyping in allogeneic stem cell transplant patients considered for pentamidine administration. Clin Transplant. 2011 Feb 7. doi: 10.1111/j.1399-0012.2011.01399.x. - Pubmed
DTHybrid score 0.4472
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Li XQ, Bjorkman A, Andersson TB, Gustafsson LL, Masimirembwa CM: Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. Epub 2003 Aug 12. - Pubmed
DTHybrid score 0.3303
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Li XQ, Bjorkman A, Andersson TB, Gustafsson LL, Masimirembwa CM: Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. Epub 2003 Aug 12. - Pubmed
DTHybrid score 0.5247
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Li XQ, Bjorkman A, Andersson TB, Gustafsson LL, Masimirembwa CM: Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. Epub 2003 Aug 12. - Pubmed
DTHybrid score 0.3783
Cytochrome P450 4A11
Name Cytochrome P450 4A11
Gene Name CYP4A11
Actions substrate
References
  • Li XQ, Bjorkman A, Andersson TB, Gustafsson LL, Masimirembwa CM: Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. Epub 2003 Aug 12. - Pubmed
DTHybrid score 0.1589
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5057
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3683
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7146

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.386
1588 Multidrug resistance protein 1 ABCB1 0.2913
6107 Cytochrome P450 3A7 CYP3A7 0.2251
6030 Cytochrome P450 2B6 CYP2B6 0.2106
6013 Cytochrome P450 2E1 CYP2E1 0.2027
5718 Cytochrome P450 2A6 CYP2A6 0.1328
4325 tRNA trmD 0.1287
4328 tRNA trmD 0.1287
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1076
587 Serum albumin ALB 0.0939
6106 Cytochrome P450 2C18 CYP2C18 0.0888
20 Prostaglandin G/H synthase 1 PTGS1 0.0829
1898 Cytochrome P450 1B1 CYP1B1 0.0816
492 Histamine H1 receptor HRH1 0.073
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0723
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0656
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0621
824 Sodium-dependent serotonin transporter SLC6A4 0.0616
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0598
862 Multidrug resistance-associated protein 1 ABCC1 0.0542
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0535
831 D(2) dopamine receptor DRD2 0.0514
502 5-hydroxytryptamine 2A receptor HTR2A 0.0512
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0509
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0487
3811 Cytochrome P450 19A1 CYP19A1 0.0487
6145 Solute carrier family 22 member 1 SLC22A1 0.0487
1729 Solute carrier family 22 member 6 SLC22A6 0.048
556 Alpha-1A adrenergic receptor ADRA1A 0.0476
6144 Solute carrier family 22 member 2 SLC22A2 0.046
776 Bile salt export pump ABCB11 0.0457
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0441
290 Prostaglandin G/H synthase 2 PTGS2 0.0441
766 Beta-2 adrenergic receptor ADRB2 0.0429
318 Alpha-2A adrenergic receptor ADRA2A 0.0416
871 Glucocorticoid receptor NR3C1 0.0406
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0399
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0393
193 Beta-1 adrenergic receptor ADRB1 0.0387
320 5-hydroxytryptamine 1A receptor HTR1A 0.0377
136 Estrogen receptor ESR1 0.037
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0369
6031 Cytochrome P450 3A43 CYP3A43 0.0363
847 Mu-type opioid receptor OPRM1 0.0348
590 5-hydroxytryptamine 2C receptor HTR2C 0.0348
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0347
713 Sodium-dependent dopamine transporter SLC6A3 0.0347
23 D(1A) dopamine receptor DRD1 0.0346
118 Organic cation/carnitine transporter 2 SLC22A5 0.0335
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0331
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0328
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0323
341 5-hydroxytryptamine 3 receptor HTR3A 0.0321
632 Alpha-1B adrenergic receptor ADRA1B 0.0321
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0317
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0314
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0299
3941 Amine oxidase [flavin-containing] A MAOA 0.0299
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0297
731 HIV-1 protease HIV-1 protease 0.0294
85 Growth hormone receptor GHR 0.0291
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0288
467 Delta-type opioid receptor OPRD1 0.0285
6142 Solute carrier family 22 member 8 SLC22A8 0.0279
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0277
6143 Solute carrier family 22 member 7 SLC22A7 0.0271
817 DNA topoisomerase 2-alpha TOP2A 0.0269
3923 Cholinesterase BCHE 0.0269
638 D(3) dopamine receptor DRD3 0.0267
696 Kappa-type opioid receptor OPRK1 0.0267
3238 Multidrug resistance protein mexA mexA 0.0266
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0265
3116 Bacterioferritin bfr 0.0265
4906 Bacterioferritin bfr 0.0265
4965 Bacterioferritin bfr 0.0265
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0265
3173 Enolase eno 0.0265
3709 Glycerol uptake facilitator protein glpF 0.0265
3393 TGF-beta receptor type-2 TGFBR2 0.0265
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0265
885 5-hydroxytryptamine 1B receptor HTR1B 0.0265
444 Alcohol dehydrogenase 1B ADH1B 0.0261
36 Insulin receptor INSR 0.0258
260 Cytochrome P450 51 ERG11 0.0256
761 Cytochrome P450 51 ERG11 0.0256
3163 Cytochrome P450 51 cyp51 0.0256
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0256
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.025
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0244
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0243
6147 Solute carrier family 22 member 3 SLC22A3 0.0239
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0239
6182 Cytochrome P450 2J2 CYP2J2 0.0238
2164 Multidrug resistance-associated protein 4 ABCC4 0.0237
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0237
465 Calmodulin CALM1 0.0236
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0233
2852 DNA mismatch repair protein mutL mutL 0.0231
3932 Glutathione S-transferase A2 GSTA2 0.023
833 Organic cation/carnitine transporter 1 SLC22A4 0.0226
6459 Glycodelin PAEP 0.0225
629 Alpha-2B adrenergic receptor ADRA2B 0.0224
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0224
777 Tumor necrosis factor TNF 0.0222
904 Glutathione S-transferase P GSTP1 0.0219
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0217
725 5-hydroxytryptamine 1D receptor HTR1D 0.0216
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0212
3221 Cytochrome c4 cc4 0.0212
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.021
3191 Histidinol dehydrogenase hisD 0.0209
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0209
4203 Histamine N-methyltransferase HNMT 0.0208
3939 Amine oxidase [flavin-containing] B MAOB 0.0207
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0207
789 Alpha-1D adrenergic receptor ADRA1D 0.0205
378 Alpha-2C adrenergic receptor ADRA2C 0.0205
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.02
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0198
740 Argininosuccinate synthase ASS1 0.0196
865 Argininosuccinate synthase ASS1 0.0196
2680 Argininosuccinate synthase argG 0.0196
3194 Argininosuccinate synthase argG 0.0196
4692 A/G-specific adenine glycosylase mutY 0.0195
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0193
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0192
4330 Hypothetical protein TTHA0667 TTHA0667 0.0192
4313 Probable tRNA/rRNA methyltransferase HI0766 trmL 0.0192
1998 Protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 0.0192
2551 Cobalt-precorrin-4 C(11)-methyltransferase cbiF 0.0192
4315 DNA adenine methylase DAM 0.0192
3724 Protein methyltransferase hemK hemK 0.0192
4316 Mycolic acid synthase pcaA 0.0192
4333 Protein-L-isoaspartate O-methyltransferase pcm 0.0192
4323 Modification methylase HhaI hhaIM 0.0192
4314 Modification methylase PvuII pvuIIM 0.0192
4324 Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 SETD7 0.0192
4329 Uroporphyrinogen-III C-methyltransferase cobA 0.0192
4331 Chemotaxis protein methyltransferase cheR 0.0192
4309 S-adenosyl-L-methionine-dependent methyltransferase mraW rsmH 0.0192
146 Androgen receptor AR 0.0191
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0189
380 Cytochrome P450 17A1 CYP17A1 0.0188
844 Epidermal growth factor receptor EGFR 0.0188
477 DNA topoisomerase 4 subunit A parC 0.0186
886 DNA topoisomerase 4 subunit A parC 0.0186
6226 DNA topoisomerase 4 subunit A parC 0.0186
2802 Endoglucanase G celCCG 0.0185
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0185
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0185
6014 Cytochrome P450 2A13 CYP2A13 0.0184
404 DNA gyrase subunit A gyrA 0.0183
6224 DNA gyrase subunit A gyrA 0.0183
84 Nuclear receptor 0B1 NR0B1 0.0183
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0181
6316 ADP-ribosylation factor 1 ARF1 0.0181
6136 Multidrug resistance-associated protein 5 ABCC5 0.0181
432 D(4) dopamine receptor DRD4 0.018
3426 Glutamine synthetase glnA 0.018
3987 Glutamine synthetase GLUL 0.018
6148 Multidrug resistance-associated protein 7 ABCC10 0.0174
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0173
6220 Aryl hydrocarbon receptor AHR 0.0172
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0171
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0171
3117 Carminomycin 4-O-methyltransferase dnrK 0.0168
4302 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 mmaA2 0.0168
2242 Cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 0.0168
4310 rRNA adenine N-6-methyltransferase ermC' 0.0168
4332 Modification methylase TaqI taqIM 0.0167
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0167
4306 HemK protein TM_0488 0.0167
2297 Genome polyprotein Not Available 0.0166
2322 Genome polyprotein Not Available 0.0166
2694 Genome polyprotein Not Available 0.0166
2719 Genome polyprotein Not Available 0.0166
2860 Genome polyprotein Not Available 0.0166
2928 Genome polyprotein Not Available 0.0166
3160 Genome polyprotein Not Available 0.0166
3260 Genome polyprotein Not Available 0.0166
4783 Genome polyprotein Not Available 0.0166
5726 Genome polyprotein Not Available 0.0166
5779 Genome polyprotein Not Available 0.0166
5867 Genome polyprotein Not Available 0.0166
6253 Genome polyprotein Not Available 0.0166
6301 Genome polyprotein Not Available 0.0166
6380 Genome polyprotein Not Available 0.0166
6381 Genome polyprotein Not Available 0.0166
6437 Genome polyprotein Not Available 0.0166
6520 Genome polyprotein Not Available 0.0166
6521 Genome polyprotein Not Available 0.0166
6652 Genome polyprotein Not Available 0.0166
6734 Genome polyprotein Not Available 0.0166
6735 Genome polyprotein Not Available 0.0166
6736 Genome polyprotein Not Available 0.0166
6737 Genome polyprotein Not Available 0.0166
6738 Genome polyprotein Not Available 0.0166
6739 Genome polyprotein Not Available 0.0166
6744 Genome polyprotein Not Available 0.0166
6748 Genome polyprotein Not Available 0.0166
6894 Genome polyprotein Not Available 0.0166
6898 Genome polyprotein Not Available 0.0166
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0163
4318 Siroheme synthase cysG 0.0161
614 Progesterone receptor PGR 0.016
6137 Multidrug resistance-associated protein 6 ABCC6 0.0158
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0158
1757 Myeloperoxidase MPO 0.0157
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0157
122 P2Y purinoceptor 12 P2RY12 0.0155
4327 RdmB rdmB 0.0154
2653 Modification methylase RsrI rsrIM 0.0154
504 Mast/stem cell growth factor receptor KIT 0.0151
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.015
3947 Xanthine dehydrogenase/oxidase XDH 0.0148
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0142
820 Glycine receptor subunit alpha-2 GLRA2 0.0142
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0139
232 Corticosteroid-binding globulin SERPINA6 0.0139
436 5-hydroxytryptamine 2B receptor HTR2B 0.0135
1024 Solute carrier family 22 member 11 SLC22A11 0.0133
1010 Cytochrome P450 51A1 CYP51A1 0.0133
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0133
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0133
16 Adenosine A1 receptor ADORA1 0.0132
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0132
1517 Beta-3 adrenergic receptor ADRB3 0.013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0129
411 Glycine N-methyltransferase GNMT 0.0129
1178 Adenosine A2a receptor ADORA2A 0.0127
737 Mineralocorticoid receptor NR3C2 0.0127
124 Histamine H2 receptor HRH2 0.0127
2557 Cap-specific mRNA PAPS 0.0126
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0126
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0126
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0124
624 Guanidinoacetate N-methyltransferase GAMT 0.0124
613 Atrial natriuretic peptide receptor A NPR1 0.0122
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0122
26 Vascular endothelial growth factor receptor 3 FLT4 0.0121
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0121
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.012
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0119
811 Translocator protein TSPO 0.0119
756 Sex hormone-binding globulin SHBG 0.0119
6102 Arylamine N-acetyltransferase 2 NAT2 0.0119
228 Beta platelet-derived growth factor receptor PDGFRB 0.0118
818 50S ribosomal protein L10 rplJ 0.0118
407 Vascular endothelial growth factor receptor 2 KDR 0.0118
251 Alcohol dehydrogenase 1A ADH1A 0.0117
94 5-hydroxytryptamine 4 receptor HTR4 0.0117
569 Retinal dehydrogenase 2 ALDH1A2 0.0117
716 5-hydroxytryptamine 7 receptor HTR7 0.0117
163 D(1B) dopamine receptor DRD5 0.0116
32 Vascular endothelial growth factor receptor 1 FLT1 0.0116
48 Pyridoxal kinase PDXK 0.0116
6146 High affinity copper uptake protein 1 SLC31A1 0.0116
974 Phenylethanolamine N-methyltransferase PNMT 0.0115
2112 Toll-like receptor 9 TLR9 0.0115
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0115
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0115
4604 Liver carboxylesterase 1 CES1 0.0115
6141 Sodium/bile acid cotransporter SLC10A1 0.0114
482 Glycine receptor subunit alpha-1 GLRA1 0.0114
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0113
2449 Tubulin alpha-3 chain TUBA1A 0.0113
719 Retinoic acid receptor responder protein 1 RARRES1 0.0113
770 Retinoic acid-induced protein 3 GPRC5A 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
373 Transthyretin TTR 0.0112
70 Type-1 angiotensin II receptor AGTR1 0.0111
4148 Serine/threonine-protein kinase mTOR MTOR 0.011
571 Melatonin receptor type 1A MTNR1A 0.011
362 Melatonin receptor type 1B MTNR1B 0.011
88 Retinoic acid receptor RXR-beta RXRB 0.0109
611 Retinal dehydrogenase 1 ALDH1A1 0.0109
284 DNA-directed RNA polymerase beta chain rpoB 0.0108
5773 DNA-directed RNA polymerase beta chain rpoB 0.0108
952 Dipeptidyl peptidase 4 DPP4 0.0107
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0107
469 Annexin A1 ANXA1 0.0106
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0104
6020 Aldehyde oxidase AOX1 0.0104
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0103
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0103
474 Acetylcholinesterase ACHE 0.0102
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.01
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.01
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.01
780 Retinoic acid receptor RXR-gamma RXRG 0.0099
161 Tubulin beta chain TUBB 0.0099
312 Tubulin beta chain TUB2 0.0099
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0098
162 Retinoic acid receptor gamma-1 RARG 0.0098
29 Tubulin beta-1 chain TUBB1 0.0097
869 Estrogen receptor beta ESR2 0.0097
921 Glutamate receptor 2 GRIA2 0.0097
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0097
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0097
1656 CYP2B protein CYP2B 0.0096
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0096
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0096
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0096
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0096
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0096
1256 5-hydroxytryptamine 6 receptor HTR6 0.0096
4120 NADPH--cytochrome P450 reductase POR 0.0095
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0095
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0094
4122 Histone deacetylase 2 HDAC2 0.0094
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0093
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0092
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0092
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0089
365 Dihydrofolate reductase DHFR 0.0089
2381 Dihydrofolate reductase DFR1 0.0089
2833 Dihydrofolate reductase Not Available 0.0089
2931 Dihydrofolate reductase folA 0.0089
3544 Dihydrofolate reductase folA 0.0089
3682 Dihydrofolate reductase folA 0.0089
6642 Dihydrofolate reductase folA 0.0089
6756 Dihydrofolate reductase dfrA 0.0089
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0088
517 Alcohol dehydrogenase 1C ADH1C 0.0088
823 Fibroblast growth factor receptor 2 FGFR2 0.0087
33 Cystine/glutamate transporter SLC7A11 0.0087
427 Substance-P receptor TACR1 0.0085
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0085
908 Glutathione S-transferase theta-1 GSTT1 0.0084
891 Dihydropteroate synthase folP 0.0084
5359 Dihydropteroate synthase folP 0.0084
7175 Dihydropteroate synthase sulI 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0083
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0082
2539 Tubulin alpha-1 chain TUBA4A 0.0082
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0081
814 Ryanodine receptor 1 RYR1 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.008
5300 Antigen peptide transporter 1 TAP1 0.008
705 Glutamate receptor 1 GRIA1 0.0079
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0079
173 Toll-like receptor 7 TLR7 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0078
1629 Transcription factor AP-1 JUN 0.0077
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0076
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0076
131 Synaptic vesicular amine transporter SLC18A2 0.0076
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0076
295 Carbonic anhydrase 1 CA1 0.0075
528 5-hydroxytryptamine 1E receptor HTR1E 0.0075
239 Coagulation factor X F10 0.0074
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0074
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0074
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0073
68 Cannabinoid receptor 1 CNR1 0.0073
273 Apoptosis regulator Bcl-2 BCL2 0.0072
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0071
6163 Copper-transporting ATPase 2 ATP7B 0.007
6165 Copper-transporting ATPase 1 ATP7A 0.007
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.007
592 Carbonic anhydrase 4 CA4 0.007
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.007
275 Arachidonate 5-lipoxygenase ALOX5 0.007
6043 Putative G-protein coupled receptor 44 GPR44 0.007
1050 Bile salt sulfotransferase SULT2A1 0.007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.007
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0068
1192 Sulfotransferase 1A1 SULT1A1 0.0068
856 Vitamin D3 receptor VDR 0.0068
3086 Plasmepsin-2 Not Available 0.0068
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0067
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0067
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0067
208 DNA-directed RNA polymerase beta' chain rpoC 0.0065
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0065
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0065
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0065
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0064
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0064
976 Platelet glycoprotein IX GP9 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0063
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0063
896 Glutathione S-transferase Mu 1 GSTM1 0.0062
581 Cytochrome P450 2R1 CYP2R1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
7 Nitric oxide synthase, inducible NOS2 0.0061
738 Monocarboxylate transporter 1 SLC16A1 0.0061
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0061
165 FL cytokine receptor FLT3 0.0061
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
634 Squalene monooxygenase SQLE 0.0061
7196 Squalene monooxygenase ERG1 0.0061
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0061
4237 50S ribosomal protein L22 rplV 0.006
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.006
6044 Serum paraoxonase/lactonase 3 PON3 0.006
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
518 Peroxidase/catalase T katG 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0057
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0057
1714 Mitogen-activated protein kinase 3 MAPK3 0.0056
6085 Fatty acid-binding protein, intestinal FABP2 0.0056
1618 High affinity nerve growth factor receptor NTRK1 0.0056
183 Vascular endothelial growth factor A VEGFA 0.0055
6506 Stathmin-4 STMN4 0.0055
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
511 5-hydroxytryptamine 1F receptor HTR1F 0.0054
1483 Membrane copper amine oxidase AOC3 0.0054
3856 Fibroblast growth factor receptor 3 FGFR3 0.0053
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0053
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
5934 Cytochrome P450 26A1 CYP26A1 0.0052
4103 Proteasome subunit beta type 2 PSMB2 0.0052
4102 Proteasome subunit beta type 5 PSMB5 0.0052
4101 Proteasome subunit beta type 1 PSMB1 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
357 Carbonic anhydrase 2 CA2 0.0052
49 Endothelin B receptor EDNRB 0.0052
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
6432 Transporter snf 0.0051
4192 DNA topoisomerase 2-beta TOP2B 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6174 50S ribosomal protein L32 rpmF 0.005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.005
768 FK506-binding protein 1A FKBP1A 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.005
1541 Metalloproteinase mmp20 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
1196 Complement decay-accelerating factor CD55 0.0049
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0049
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0049
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0049
174 Sigma 1-type opioid receptor SIGMAR1 0.0049
714 Glutathione reductase, mitochondrial GSR 0.0048
1992 Vitamin D-binding protein GC 0.0048
1648 Elastin ELN 0.0048
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0048
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0047
153 Dopamine beta-hydroxylase DBH 0.0047
106 Cannabinoid receptor 2 CNR2 0.0046
54 Prothrombin F2 0.0045
4238 50S ribosomal protein L4 rplD 0.0045
5578 50S ribosomal protein L4 rplD 0.0045
6173 50S ribosomal protein L4 rplD 0.0045
6219 50S ribosomal protein L4 rplD 0.0045
6126 Carbonic anhydrase 7 CA7 0.0044
936 Ephrin type-A receptor 2 EPHA2 0.0044
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0043
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0043
3957 Adenosine deaminase ADA 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
2808 Chloramphenicol acetyltransferase 3 cat3 0.0043
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0043
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.0039
3809 Estrogen-related receptor gamma ESRRG 0.0039
1630 Integrin beta-2 ITGB2 0.0039
1852 Microtubule-associated protein 2 MAP2 0.0039
5787 Angiopoietin-1 receptor TEK 0.0039
3601 Dihydropteroate synthase 1 folP1 0.0039
3807 Dihydropteroate synthase 1 folP1 0.0039
3808 Dihydropteroate synthase 2 folP2 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2417 Chloramphenicol acetyltransferase cat 0.0039
3278 Chloramphenicol acetyltransferase cat 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2810 Dr hemagglutinin structural subunit draA 0.0039
563 Thyroid peroxidase TPO 0.0038
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0038
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0038
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0038
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0038
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0038
1063 Signal transducer and activator of transcription 5B STAT5B 0.0038
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0038
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0038
268 Adenosine A2b receptor ADORA2B 0.0037
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0037
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0037
267 Plasminogen activator inhibitor 1 SERPINE1 0.0037
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0036
3830 Calreticulin CALR 0.0036
3937 Fatty-acid amide hydrolase FAAH 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
1374 Natriuretic peptides B NPPB 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1827 Gap junction alpha-1 protein GJA1 0.0035
1908 Vascular cell adhesion protein 1 VCAM1 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0034
164 Histamine H4 receptor HRH4 0.0034
6034 Hydroxyindole O-methyltransferase ASMT 0.0034
6035 Nuclear receptor ROR-beta RORB 0.0034
6036 Eosinophil peroxidase EPX 0.0034
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0033
229 Retinoic acid receptor beta RARB 0.0033
6221 Steroid hormone receptor ERR1 ESRRA 0.0033
24 Thymidylate synthase TMP1 0.0033
359 Thymidylate synthase TYMS 0.0033
2626 Thymidylate synthase thyA 0.0033
2729 Thymidylate synthase thyA 0.0033
5352 Thymidylate synthase THYA 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
5924 Microtubule-associated protein 4 MAP4 0.0032
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1275 Estrogen sulfotransferase SULT1E1 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0031
484 Tyrosine-protein kinase ABL2 ABL2 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.003
572 Integrin alpha-L ITGAL 0.0029
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0029
6138 Multidrug resistance protein 3 ABCB4 0.0029
765 Indoleamine 2,3-dioxygenase IDO1 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
6824 Tyrosine-protein kinase Lyn LYN 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
3810 Catechol O-methyltransferase COMT 0.0028
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0028
822 Aldose reductase AKR1B1 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
4773 Deoxycytidine kinase DCK 0.0027
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0027
473 L-lactate dehydrogenase A chain LDHA 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1864 RET proto-oncogene RET 0.0027
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0027
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0027
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0026
6048 Troponin C, skeletal muscle TNNC2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
1039 Histone deacetylase 9 HDAC9 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0025
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0025
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0025
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
3917 Methylenetetrahydrofolate reductase MTHFR 0.0025
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0025
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
3404 Exotoxin A eta 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
4217 Telomerase reverse transcriptase TERT 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
1353 DNA topoisomerase 1 TOP1 0.0021
3552 DNA topoisomerase 1 topA 0.0021
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0021
627 11-cis retinol dehydrogenase RDH5 0.002
422 Vitamin K-dependent protein C PROC 0.002
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
1525 Heparin-binding growth factor 2 FGF2 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
5798 Mitogen-activated protein kinase 11 MAPK11 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
2320 Thymidine kinase, cytosolic TK1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
798 Osteocalcin BGLAP 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
1243 Cathepsin D CTSD 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
3233 Bile acid receptor NR1H4 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0015
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0015
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0015
6218 Pannexin-1 PANX1 0.0015
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
2021 Thrombomodulin THBD 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0014
1341 Histamine H3 receptor HRH3 0.0014
6859 Protein S100-A4 S100A4 0.0014
291 Nitric-oxide synthase, endothelial NOS3 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
2207 Rhodopsin RHO 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
816 Biliverdin reductase A BLVRA 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0011
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0011
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0011
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0011
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0011
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0011
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0011
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0011
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0011
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0011
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0011
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0011
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0011
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0011
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0011
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0011
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0011
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0011
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0011
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0011
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0011
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0011
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0011
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0011
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0011
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0011
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0011
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0011
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
345 Plasma retinol-binding protein RBP4 0.001
1792 Tissue-type plasminogen activator PLAT 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
328 Sorbitol dehydrogenase SORD 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
597 Dihydropteridine reductase QDPR 0.001
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0009
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0009
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0009
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0009
6677 Myelin P2 protein PMP2 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
626 Cysteine dioxygenase type 1 CDO1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0009
12 Alcohol dehydrogenase class 3 ADH5 0.0009
77 L-lactate dehydrogenase B chain LDHB 0.0009
2132 Protein S100-B S100B 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
279 Tyrosinase TYR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0008
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
654 Flavin reductase BLVRB 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
↑