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Uroporphyrinogen-III C-methyltransferase


Partner ID 4329
Name Uroporphyrinogen-III C-methyltransferase
Synonyms 6831
Gene name cobA
General function Involved in methyltransferase activity
Specific function Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin
Gene sequence + ...

ATGATCGACGACCTCTTTGCCGGATTGCCGGCGCTCGAAAAAGGTTCGGTCTGGCTGGTCGGCGCCGGCCCCGGCGATCCCGGCCTGTTGACGCTGCATGCGGCCAATGCGCTGCGCCAGGCGGATGTGATCGTGCATGATGCGCTGGTCAACGAGGATTGCCTGAAGCTCGCGCGGCCGGGCGCCGTGCTGGAGTTTGCGGGCAAGCGTGGCGGCAAGCCGTCGCCGAAGCAGCGCGACATCTCGCTTCGCCTCGTCGAACTCGCGCGCGCCGGCAACCGGGTGCTGCGCCTCAAAGGCGGCGATCCCTTCGTCTTCGGTCGCGGTGGCGAGGAGGCGCTGACGCTGGTCGAACACCAGGTGCCGTTCCGAATCGTGCCCGGCATCACCGCCGGTATCGGCGGGCTTGCCTATGCCGGCATTCCCGTGACCCATCGCGAGGTCAACCACGCGGTCACTTTCCTGACTGGCCATGATTCCTCCGGCCTGGTGCCGGATCGCATCAACTGGCAGGGCATCGCCAGCGGCTCGCCTGTCATCGTCATGTACATGGCGATGAAACATATCGGCGCGATCACCGCCAACCTCATTGCCGGCGGCCGCTCGCCGGACGAACCGGTCGCCTTCGTCTGCAACGCCGCGACGCCGCAGCAGGCGGTGCTGGAAACGACGCTTGCGCGTGCAGAGGCCGATGTTGCGGCGGCAGGGCTGGAGCCGCCGGCGATCGTCGTCGTCGGCGAGGTGGTGCGGCTGCGCGCAGCGCTCGACTGGATCGGCGCGCTGGACGGGCGCAAGCTTGCCGCCGACCCGTTCGCCAATCGCATTCTCAGGAACCCGGCATGA
Protein sequence + ...

MIDDLFAGLPALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNEDCLKLARPGAVLEFAGKRGGKPSPKQRDISLRLVELARAGNRVLRLKGGDPFVFGRGGEEALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVTFLTGHDSSGLVPDRINWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPDEPVAFVCNAATPQQAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAALDWIGALDGRKLAADPFANRILRNPA
GO Classification
function
C-methyltransferase activity
uroporphyrin-III C-methyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
process
porphyrin metabolism
porphyrin biosynthesis
physiological process
metabolism
cellular metabolism
heterocycle metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01752 S-Adenosyl-L-Homocysteine

Associated as Prediction

Id Name
DB00118 S-Adenosylmethionine
DB00145 Glycine
DB00148 Creatine
DB00536 Guanidine
DB00613 Amodiaquine
DB00667 Histamine Phosphate
DB00738 Pentamidine
DB00878 Chlorhexidine
DB01103 Quinacrine
DB01693 Ribavirin Monophosphate
DB01718 Cetyl-Trimethyl-Ammonium
DB01752 S-Adenosyl-L-Homocysteine
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01910 Adenosyl-Ornithine
DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate
DB01978 7,9-Dimethylguanine
DB02282 5'-Deoxy-5'-Methylthioadenosine
DB02751 N-[Amino(Imino)Methyl]Glycine
DB03164 6-Amino-1-Methylpurine
DB03199 4-Methoxy-E-Rhodomycin T
DB03219 11-Deoxy-Beta-Rhodomycin
DB03358 7n-Methyl-8-Hydroguanosine-5'-Triphosphate
DB03468 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide
DB03473 N5-Methylglutamine
DB03493 7-Methylguanosine
DB03824 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
DB04077 Glycerol
DB04103 3-Methylcytosine
DB04221 Didecyl-Dimethyl-Ammonium
DB04272 Citric Acid
DB04273 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
DB04314 1-Methylcytosine
DB04522 Phosphonoserine
DB04655 METOPRINE, METHODICHLOROPHEN
DB07106 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE
DB07597 CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
DB07739 (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
DB07747 (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB07798 (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB07906 [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL
DB08128 (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine
DB08129 (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
DB08550 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE
DB08631 N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB08654 TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
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