DT-Web: DB04272

Identification

Name

Citric Acid

Accession Number

DB04272 (EXPT00922)

Type

small molecule

Description

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

192.1235

Groups

experimental

Monoisotopic Weight

192.02700261

Pharmacology

Indication

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Protein binding

Not Available

Biotransformation

Not Available

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Interactions

Drug Interactions

Drug	Mechanism of interaction
Azilsartan medoxomil	Increases serum potassium.
Eltrombopag	Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Lithium	The urine alkalizer decreases the effect of lithium

Food Interactions

Not Available

KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase
Name	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase
Gene Name	eda
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0169
Molybdopterin-guanine dinucleotide biosynthesis protein A
Name	Molybdopterin-guanine dinucleotide biosynthesis protein A
Gene Name	mobA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9512
Fumarate hydratase class II
Name	Fumarate hydratase class II
Gene Name	fumC
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.8679
6-phosphogluconolactonase
Name	6-phosphogluconolactonase
Gene Name	pgl
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.901
Oxygen-insensitive NAD(P)H nitroreductase
Name	Oxygen-insensitive NAD(P)H nitroreductase
Gene Name	nfnB
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.6664
Pol polyprotein
Name	Pol polyprotein
Gene Name	gag-pro-pol
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.8828
L-amino-acid oxidase
Name	L-amino-acid oxidase
Gene Name	IL4I1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Macrophage migration inhibitory factor
Name	Macrophage migration inhibitory factor
Gene Name	MIF
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	2.0236
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Name	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Gene Name	CTDSP1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Name	1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene Name	dxr
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	2.0179
Tryptophan synthase alpha chain
Name	Tryptophan synthase alpha chain
Gene Name	trpA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.2172
Sialidase
Name	Sialidase
Gene Name	nedA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0386
RNASE4 protein
Name	RNASE4 protein
Gene Name	RNASE4
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0088
Cytochrome c peroxidase
Name	Cytochrome c peroxidase
Gene Name	Not Available
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.8974
Hepatocyte growth factor-regulated tyrosine kinase substrate
Name	Hepatocyte growth factor-regulated tyrosine kinase substrate
Gene Name	HGS
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Invasin
Name	Invasin
Gene Name	YPTB1668
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0156
Intron-associated endonuclease 1
Name	Intron-associated endonuclease 1
Gene Name	ITEVIR
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0166
Short tail fiber protein
Name	Short tail fiber protein
Gene Name	12
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0161
Malate dehydrogenase, mitochondrial
Name	Malate dehydrogenase, mitochondrial
Gene Name	MDH2
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.724
N5-carboxyaminoimidazole ribonucleotide mutase
Name	N5-carboxyaminoimidazole ribonucleotide mutase
Gene Name	purE
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0172
50S ribosomal protein L4
Name	50S ribosomal protein L4
Gene Name	rplD
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0168
Carboxypeptidase B
Name	Carboxypeptidase B
Gene Name	CPB1
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	2.418
Medium-chain-fatty-acid--CoA ligase
Name	Medium-chain-fatty-acid--CoA ligase
Gene Name	Not Available
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.8431
Hexon protein
Name	Hexon protein
Gene Name	PII
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0156
Riboflavin kinase/FMN adenylyltransferase
Name	Riboflavin kinase/FMN adenylyltransferase
Gene Name	TM_0857
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0446
Beta-fructosidase
Name	Beta-fructosidase
Gene Name	bfrA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0162
Regulator of transcription; stringent starvation protein A
Name	Regulator of transcription; stringent starvation protein A
Gene Name	sspA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0169
Citrate synthase
Name	Citrate synthase
Gene Name	cit
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.0069
RNA 3'-terminal phosphate cyclase
Name	RNA 3'-terminal phosphate cyclase
Gene Name	rtcA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	Not Available
U6 snRNA-associated Sm-like protein LSm6
Name	U6 snRNA-associated Sm-like protein LSm6
Gene Name	LSM6
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Pleckstrin homology domain-containing family A member 1
Name	Pleckstrin homology domain-containing family A member 1
Gene Name	PLEKHA1
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0163
Iron(III)-binding periplasmic protein
Name	Iron(III)-binding periplasmic protein
Gene Name	fbpA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0165
Cell division protein FtsY
Name	Cell division protein FtsY
Gene Name	TM_0570
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0166
Nicotinate-nucleotide adenylyltransferase
Name	Nicotinate-nucleotide adenylyltransferase
Gene Name	nadD
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.896
N utilization substance protein B homolog
Name	N utilization substance protein B homolog
Gene Name	nusB
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0174
Complement component C8 gamma chain
Name	Complement component C8 gamma chain
Gene Name	C8G
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0169
Ribonucleoside-diphosphate reductase subunit beta
Name	Ribonucleoside-diphosphate reductase subunit beta
Gene Name	nrdF
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0165
Glutamine synthetase 1
Name	Glutamine synthetase 1
Gene Name	glnA1
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0161
Citrate synthase
Name	Citrate synthase
Gene Name	gltA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.0069
Transferase
Name	Transferase
Gene Name	Not Available
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0163
Prostaglandin F synthase
Name	Prostaglandin F synthase
Gene Name	Tb11.02.2310
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.9032
Cell division protein ftsZ
Name	Cell division protein ftsZ
Gene Name	ftsZ
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0574
Adenine phosphoribosyltransferase
Name	Adenine phosphoribosyltransferase
Gene Name	APRT
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.9968
Angiogenin
Name	Angiogenin
Gene Name	ANG
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0108
Glucose-1-phosphate thymidylyltransferase
Name	Glucose-1-phosphate thymidylyltransferase
Gene Name	rmlA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.0365
Beta-lactamase II
Name	Beta-lactamase II
Gene Name	blm
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.532
Glyoxalase family protein
Name	Glyoxalase family protein
Gene Name	BC_1747
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.919
Uridine-cytidine kinase 2
Name	Uridine-cytidine kinase 2
Gene Name	UCK2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.241
Tumor necrosis factor ligand superfamily member 13B
Name	Tumor necrosis factor ligand superfamily member 13B
Gene Name	TNFSF13B
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.706
UPF0124 protein yfiH
Name	UPF0124 protein yfiH
Gene Name	yfiH
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0167
Betaine--homocysteine S-methyltransferase 1
Name	Betaine--homocysteine S-methyltransferase 1
Gene Name	BHMT
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.3735
Ribose-5-phosphate isomerase A
Name	Ribose-5-phosphate isomerase A
Gene Name	rpiA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0169
Tryptophanyl-tRNA synthetase
Name	Tryptophanyl-tRNA synthetase
Gene Name	trpS
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.2127
GMP synthase [glutamine-hydrolyzing]
Name	GMP synthase [glutamine-hydrolyzing]
Gene Name	guaA
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.9726
Aldose reductase
Name	Aldose reductase
Gene Name	AKR1B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.9894
Inosine triphosphate pyrophosphatase
Name	Inosine triphosphate pyrophosphatase
Gene Name	ITPA
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Citrate synthase, mitochondrial
Name	Citrate synthase, mitochondrial
Gene Name	CS
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Lysozyme
Name	Lysozyme
Gene Name	17
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.0048
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Name	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Gene Name	HS3ST3A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1586
Glycerol uptake operon antiterminator-related protein
Name	Glycerol uptake operon antiterminator-related protein
Gene Name	TM_1436
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.0171
cGMP-specific 3',5'-cyclic phosphodiesterase
Name	cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name	PDE5A
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	Not Available
3-carboxy-cis,cis-muconate cycloisomerase
Name	3-carboxy-cis,cis-muconate cycloisomerase
Gene Name	pcaB
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.9282
Proto-oncogene tyrosine-protein kinase Src
Name	Proto-oncogene tyrosine-protein kinase Src
Gene Name	SRC
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	2.0599
Pyruvate decarboxylase
Name	Pyruvate decarboxylase
Gene Name	pdc
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	1.016
Ribonuclease pancreatic
Name	Ribonuclease pancreatic
Gene Name	RNASE1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.8949
Isocitrate dehydrogenase [NADP]
Name	Isocitrate dehydrogenase [NADP]
Gene Name	icd
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.0164
Glycine N-methyltransferase
Name	Glycine N-methyltransferase
Gene Name	GNMT
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.7217
Eosinophil cationic protein
Name	Eosinophil cationic protein
Gene Name	RNASE3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9884
Beta-lactamase
Name	Beta-lactamase
Gene Name	penP
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.3387

Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	inhibitor
References	Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. - Pubmed
DTHybrid score	0.5655

Id	Partner name	Gene Name	Score
2555	Pol polyprotein	pol	1.8828
3242	Pol polyprotein	gag-pol	1.8828
5256	Pol polyprotein	pol	1.8828
6469	Pol polyprotein	gag-pol	1.8828
6565	Pol polyprotein	Not Available	1.8828
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	1.6664
332	Beta-lactamase	blaZ	1.3387
2478	Beta-lactamase	ampC	1.3387
2613	Beta-lactamase	ampC	1.3387
2635	Beta-lactamase	ampC	1.3387
5445	Beta-lactamase	blaB	1.3387
6019	Beta-lactamase	SHV-7	1.3387
6701	Beta-lactamase	cphA	1.3387
6568	Tryptophan synthase alpha chain	trpA	1.2172
3301	Cell division protein ftsZ	ftsZ	1.0574
2942	Sialidase	nanH	1.0386
2838	Ribose-5-phosphate isomerase A	rpiA	1.0169
2952	Ribose-5-phosphate isomerase A	rpiA	1.0169
4238	50S ribosomal protein L4	rplD	1.0168
6173	50S ribosomal protein L4	rplD	1.0168
6219	50S ribosomal protein L4	rplD	1.0168
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.9726
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.896
252	Tryptophanyl-tRNA synthetase, cytoplasmic	WARS	0.4505
2390	Nonsecretory ribonuclease	RNASE2	0.2628
3352	Structural polyprotein	Not Available	0.2356
3628	Structural polyprotein	Not Available	0.2356
4892	Structural polyprotein	Not Available	0.2356
3490	Sigma factor sigB regulation protein rsbQ	rsbQ	0.2348
2803	Pyridoxine 5'-phosphate synthase	pdxJ	0.2256
6750	ADP-ribosylation factor 6	ARF6	0.2188
654	Flavin reductase	BLVRB	0.2062
6569	Tryptophan synthase beta chain	trpB	0.1984
2548	Subtilisin Carlsberg	apr	0.1905
3140	Hemagglutinin-neuraminidase	HN	0.1878
3609	Hemagglutinin-neuraminidase	HN	0.1878
1525	Heparin-binding growth factor 2	FGF2	0.1877
1943	Hepatocyte growth factor	HGF	0.184
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.1818
2654	Complement control protein	C3L	0.1698
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.1604
2570	Tetanus toxin	tetX	0.1471
760	Fibroblast growth factor 1	FGF1	0.1469
4335	Trans-sialidase	Not Available	0.1425
5481	Trans-sialidase	TCTS-154	0.1425
2647	RNA-directed RNA polymerase	P2	0.1382
4407	FMN-dependent NADH-azoreductase	azoR	0.134
5169	FMN-dependent NADH-azoreductase	azoR	0.134
2248	Malate synthase G	glcB	0.1284
3190	Malate synthase G	glcB	0.1284
3629	Endo-N-acetylneuraminidase	Not Available	0.1222
4600	Malonamidase E2	Not Available	0.1211
5036	Small inducible cytokine A8	CCL8	0.1209
5012	Ig lambda chain V-II region MGC	Not Available	0.1207
2297	Genome polyprotein	Not Available	0.1177
2322	Genome polyprotein	Not Available	0.1177
2694	Genome polyprotein	Not Available	0.1177
2719	Genome polyprotein	Not Available	0.1177
2860	Genome polyprotein	Not Available	0.1177
2928	Genome polyprotein	Not Available	0.1177
3160	Genome polyprotein	Not Available	0.1177
3260	Genome polyprotein	Not Available	0.1177
4783	Genome polyprotein	Not Available	0.1177
5726	Genome polyprotein	Not Available	0.1177
5779	Genome polyprotein	Not Available	0.1177
5867	Genome polyprotein	Not Available	0.1177
6253	Genome polyprotein	Not Available	0.1177
6301	Genome polyprotein	Not Available	0.1177
6380	Genome polyprotein	Not Available	0.1177
6381	Genome polyprotein	Not Available	0.1177
6437	Genome polyprotein	Not Available	0.1177
6520	Genome polyprotein	Not Available	0.1177
6521	Genome polyprotein	Not Available	0.1177
6652	Genome polyprotein	Not Available	0.1177
6734	Genome polyprotein	Not Available	0.1177
6735	Genome polyprotein	Not Available	0.1177
6736	Genome polyprotein	Not Available	0.1177
6737	Genome polyprotein	Not Available	0.1177
6738	Genome polyprotein	Not Available	0.1177
6739	Genome polyprotein	Not Available	0.1177
6744	Genome polyprotein	Not Available	0.1177
6748	Genome polyprotein	Not Available	0.1177
6894	Genome polyprotein	Not Available	0.1177
6898	Genome polyprotein	Not Available	0.1177
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.1116
5023	Glycoside hydrolase	Not Available	0.105
5024	Glycoside hydrolase	Not Available	0.105
4771	Dissimilatory copper-containing nitrite reductase	nir	0.1049
183	Vascular endothelial growth factor A	VEGFA	0.0995
2891	Circadian clock protein kaiB	kaiB	0.0979
4512	Cytochrome P450 3A4	CYP3A4	0.0979
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0964
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.0948
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0937
2757	Inorganic pyrophosphatase	ppa	0.0937
6238	Inorganic pyrophosphatase	ppa	0.0937
6968	Inorganic pyrophosphatase	PPA1	0.0937
4384	Capsule biosynthesis protein	synC	0.0902
3030	Salivary alpha-amylase	AMY1A	0.0874
2727	S-adenosylmethionine synthetase	metK	0.0864
2369	Photoactive yellow protein	pyp	0.0854
96	Histidine ammonia-lyase	HAL	0.0853
6257	Histidine ammonia-lyase	Not Available	0.0853
6536	Histidine ammonia-lyase	hutH	0.0853
6564	Prephenate dehydrogenase	tyrA	0.0853
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0839
3692	Coenzyme A biosynthesis bifunctional protein coaBC	coaBC	0.0836
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0821
6374	Disintegrin and metalloproteinase domain-containing protein 28	ADAM28	0.0816
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0816
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0812
2251	Thymidylate kinase	tmk	0.0807
2254	Thymidylate kinase	DTYMK	0.0807
3522	Thymidylate kinase	tmk	0.0807
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0803
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0803
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0803
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0777
2430	Chondroitinase B	cslB	0.0776
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0759
3354	Ras-related protein Rap-2a	RAP2A	0.0755
3335	Probable GTP-binding protein engB	engB	0.0755
3010	Regulatory protein blaR1	blaR1	0.0752
5360	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	0.0738
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.073
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.073
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.071
2765	3-deoxy-manno-octulosonate cytidylyltransferase	kpsU	0.0695
3120	3-deoxy-manno-octulosonate cytidylyltransferase	kdsB	0.0695
6316	ADP-ribosylation factor 1	ARF1	0.0692
3101	Glucose-1-phosphatase	agp	0.0685
357	Carbonic anhydrase 2	CA2	0.0682
2717	Folylpolyglutamate synthase	fgs	0.0679
1353	DNA topoisomerase 1	TOP1	0.0678
3552	DNA topoisomerase 1	topA	0.0678
4427	TDP-glucose-4,6-dehydratase	desIV	0.0678
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0677
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0677
5294	Nucleoside diphosphate kinase A	NME1	0.0669
6395	Myosin-14	MYH14	0.0669
2592	Beta-galactosidase	lacZ	0.0666
4513	Pancreatic alpha-amylase	AMY2A	0.0664
4271	Anthranilate phosphoribosyltransferase	trpD	0.0661
191	Peptide methionine sulfoxide reductase	MSRA	0.0653
1673	GTP cyclohydrolase I	GCH1	0.0653
3302	GTP cyclohydrolase I	folE	0.0653
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.0652
3209	Ornithine decarboxylase, inducible	odcI	0.0652
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0649
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0635
1758	GTPase HRas	HRAS	0.0629
4669	Endo-1,4-beta-xylanase A	xynA	0.0611
4715	Endo-1,4-beta-xylanase A	xlnA	0.0611
5560	Endo-1,4-beta-xylanase A	xynA	0.0611
3028	dTDP-4-dehydrorhamnose 3,5-epimerase	rfbC	0.061
4294	DTDP-4-dehydrorhamnose 3,5-epimerase	rmlC	0.061
5127	DTDP-4-dehydrorhamnose 3,5-epimerase	rmlC	0.061
5482	Sialidase-2	NEU2	0.0605
2794	Orotate phosphoribosyltransferase	pyrE	0.0604
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.0592
3780	Lipoprotein nlpI precursor	nlpI	0.059
5424	Endonuclease VIII-like 1	NEIL1	0.059
4411	DNA protection during starvation protein	dps	0.059
5423	UPF0010 protein HI1317	HI_1317	0.059
2503	Phosphomannomutase/phosphoglucomutase	algC	0.0589
3511	Ribonuclease 4	RNASE4	0.0579
2232	Interleukin-5	IL5	0.0579
1593	Mucin-2	MUC2	0.0576
330	Spermidine synthase	SRM	0.0572
3038	Spermidine synthase	speE	0.0572
64	Neuraminidase	NA	0.0569
641	Neuraminidase	NA	0.0569
2676	Neuraminidase	NA	0.0569
3026	Neuraminidase	NA	0.0569
3519	Neuraminidase	NA	0.0569
6007	Neuraminidase	NA	0.0569
3311	mRNA-capping enzyme	A103R	0.0568
3547	Enterotoxin type B	entB	0.0564
4819	Hydrolase	Not Available	0.0564
5249	Hydrolase	Not Available	0.0564
5436	Hydrolase	Not Available	0.0564
2371	Pantothenate kinase	coaA	0.0556
3091	Maltodextrin phosphorylase	malP	0.055
4602	Osmotically inducible protein C	tthHB8IM	0.0545
2664	S-ribosylhomocysteine lyase	luxS	0.0544
2725	S-ribosylhomocysteine lyase	luxS	0.0544
2670	Pyridoxamine kinase	pdxY	0.0544
4534	Cytohesin-2	CYTH2	0.0538
4382	Sulfotransferase family cytosolic 1B member 1	SULT1B1	0.0532
4380	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	0.0532
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0529
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0528
4563	Acetyl transferase	rimL	0.0517
3164	Biotin synthase	bioB	0.0513
3186	Soluble calcium-activated nucleotidase 1	CANT1	0.0513
3221	Cytochrome c4	cc4	0.0511
509	Thymidine kinase	TK	0.0511
570	Thymidine kinase	TK	0.0511
2559	Thymidine kinase	TK	0.0511
3430	Thymidine kinase	tdk	0.0511
3518	Thymidine kinase	TK	0.0511
5301	Thymidine kinase	tdk	0.0511
5771	Thymidine kinase	ORF36	0.0511
7009	Thymidine kinase	ORF36	0.0511
4677	Glucose-1-phosphate cytidylyltransferase	rfbF	0.0508
4676	CCA-adding enzyme	cca	0.0508
3261	Signal recognition particle protein	ffh	0.0507
6151	Monocarboxylate transporter 10	SLC16A10	0.0497
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0493
3382	Glycolipid transfer protein	GLTP	0.0491
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0479
4567	Putative acyl-CoA thioester hydrolase HI0827	HI_0827	0.0478
4564	YvbK protein	yvbK	0.0478
4576	Aac(6')-Ii protein	aac(6')-Ii	0.0478
4577	4'-phosphopantetheinyl transferase sfp	sfp	0.0477
4566	Acyl-CoA hydrolase	BC_2038	0.0477
4572	Acyl-CoA hydrolase	BH0798	0.0477
2528	Fatty acid metabolism regulator protein	fadR	0.0477
6740	Fatty acid metabolism regulator protein	fadR	0.0477
4579	Serine acetyltransferase	cysE	0.0477
6807	Serine acetyltransferase	cysE	0.0477
3599	Peroxiredoxin-2	PRDX2	0.0474
2378	Carboxymethylenebutenolidase	clcD	0.0474
4601	HMG-CoA synthase	mvaS	0.0474
2705	Dimethyl sulfoxide reductase	dmsA	0.0473
1750	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	PFKFB1	0.0473
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0466
4063	Tryptophanyl-tRNA synthetase, mitochondrial	WARS2	0.0463
90	Tryptophan 5-hydroxylase 2	TPH2	0.046
3779	Alpha-2,3/8-sialyltransferase	cst-II	0.0452
3259	Autolysin	lytA	0.0447
4531	Putative ketoacyl reductase	actIII	0.0446
358	Cystathionine beta-synthase	CBS	0.0446
5669	50S ribosomal protein L27	rpmA	0.0446
5670	Organic hydroperoxide resistance protein	ohr	0.0445
5675	Chaperone protein torD	torD	0.0445
5410	Unsaturated glucuronyl hydrolase	ugl	0.0445
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0445
5676	Axin-1	AXIN1	0.0444
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0444
5673	C protein alpha-antigen	bca	0.0444
2991	Glycerol-3-phosphate cytidylyltransferase	tagD	0.0442
2775	Dihydroorotate dehydrogenase	pyrD	0.0442
2714	Chorismate mutase	aroH	0.0437
4611	Chorismate mutase	aroG	0.0437
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0433
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.043
4757	Cytochrome P450 2C9	CYP2C9	0.0428
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0424
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0421
76	Nitric-oxide synthase, brain	NOS1	0.0417
4565	Aminoglycoside 6'-N-acetyltransferase	aac(6')-Iy	0.0416
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0415
4574	PROBABLE NAPHTHOATE SYNTHASE MENB	menB	0.0415
3489	Acetyl-coenzyme A synthetase	acs	0.0415
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0415
3024	Crotonobetainyl-CoA:carnitine CoA-transferase	caiB	0.0415
2396	Formyl-coenzyme A transferase	frc	0.0415
3457	Formyl-coenzyme A transferase	frc	0.0415
4118	Cytochrome P450 3A5	CYP3A5	0.0415
2314	Triosephosphate isomerase	TPI	0.0411
3417	Triosephosphate isomerase	tpiA	0.0411
3443	Triosephosphate isomerase	tpiA	0.0411
6346	Triosephosphate isomerase	TPI1	0.0411
3019	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	0.0408
3344	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	0.0408
3481	Glucose-1-phosphate thymidylyltransferase 2	rmlA2	0.0405
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0403
3996	Betaine--homocysteine S-methyltransferase 2	BHMT2	0.0401
901	Glutathione S-transferase Mu 4	GSTM4	0.0401
6447	Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	0.0397
738	Monocarboxylate transporter 1	SLC16A1	0.0395
3760	Penicillin-binding protein 5 precursor	dacA	0.0394
3188	IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase	ispDF	0.0393
3191	Histidinol dehydrogenase	hisD	0.0389
777	Tumor necrosis factor	TNF	0.0386
54	Prothrombin	F2	0.0386
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0385
2636	Shikimate dehydrogenase	aroE	0.0384
3515	Shikimate dehydrogenase	aroE	0.0384
3199	Phosphopantetheine adenylyltransferase	coaD	0.0383
3543	Phosphopantetheine adenylyltransferase	coaD	0.0383
3567	Phosphopantetheine adenylyltransferase	coaD	0.0383
5289	Phosphopantetheine adenylyltransferase	coaD	0.0383
2285	Streptogramin A acetyltransferase	vatD	0.0383
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0383
2560	Galactoside O-acetyltransferase	lacA	0.0383
2377	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Not Available	0.0383
3178	Formate acetyltransferase 1	pflB	0.0383
4573	Histone acetyltransferase PCAF	KAT2B	0.0383
765	Indoleamine 2,3-dioxygenase	IDO1	0.0381
4496	C-terminal-binding protein 1	CTBP1	0.038
5691	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC	rmlC	0.0375
5694	Transcription antiterminator licT	licT	0.0375
3361	Serpin B5	SERPINB5	0.0375
480	Methionine-R-sulfoxide reductase B2	MSRB2	0.037
317	Methionine-R-sulfoxide reductase	SEPX1	0.037
3995	Methionyl-tRNA synthetase, mitochondrial	MARS2	0.0369
3921	Methionine adenosyltransferase 2 subunit beta	MAT2B	0.0369
600	Methionyl-tRNA synthetase, cytoplasmic	MARS	0.0369
4037	Hypothetical protein	GPX1	0.0369
4297	Hypothetical protein	SP_1951	0.0369
4521	Hypothetical protein	BC_2969	0.0369
4540	Hypothetical protein	TM_1070	0.0369
4555	Hypothetical protein	MT1739	0.0369
4569	Hypothetical protein	mshD	0.0369
4578	Hypothetical protein	PA3270	0.0369
4747	Hypothetical protein	PA3967	0.0369
5177	Hypothetical protein	TM_0096	0.0369
5194	Hypothetical protein	PA1204	0.0369
5240	Hypothetical protein	Rv2991	0.0369
5370	Hypothetical protein	TM_1158	0.0369
5710	Hypothetical protein	Tb927.5.1360	0.0369
4545	Molybdopterin-converting factor subunit 2	moaE	0.0368
4536	Transcriptional regulator, IclR family	TM_0065	0.0368
4527	Putative hydrolase ycdX	ycdX	0.0368
4524	Mannose-6-phosphate isomerase	yvyI	0.0368
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0368
4538	Hypothetical protein VC1899	VC_1899	0.0368
4514	Citrate lyase beta subunit-like protein	citE	0.0368
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0368
4546	Aminotransferase, putative	TM_1131	0.0368
2501	Protein ygbM	ygbM	0.0368
4529	Oxalate decarboxylase oxdC	oxdC	0.0368
4548	Gyrase B	gyrB	0.0368
4547	Iron binding protein FbpA	fbpA	0.0368
658	Para-aminobenzoate synthase component 1	pabB	0.0368
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0368
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0367
4515	Peripheral plasma membrane protein CASK	CASK	0.0367
1152	Glycogen phosphorylase, muscle form	PYGM	0.0367
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0365
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0365
6142	Solute carrier family 22 member 8	SLC22A8	0.0363
4404	FcbC1 protein	fcbC	0.0362
714	Glutathione reductase, mitochondrial	GSR	0.0361
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.036
2280	Listeriolysin regulatory protein	prfA	0.0357
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0357
4811	Amylosucrase	ams	0.0357
702	UMP-CMP kinase	CMPK1	0.0354
134	Tryptophan 5-hydroxylase 1	TPH1	0.0354
2795	Methionine aminopeptidase 2	METAP2	0.0352
2723	Cholera enterotoxin subunit B	ctxB	0.0348
1050	Bile salt sulfotransferase	SULT2A1	0.0347
2376	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	0.0346
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0343
2909	Cytidylate kinase	cmk	0.0342
551	Carnitine O-acetyltransferase	CRAT	0.0341
3299	DNA primase/helicase	4	0.0339
24	Thymidylate synthase	TMP1	0.0338
359	Thymidylate synthase	TYMS	0.0338
2626	Thymidylate synthase	thyA	0.0338
2729	Thymidylate synthase	thyA	0.0338
5352	Thymidylate synthase	THYA	0.0338
819	Penicillin-binding protein 4	dacB	0.0335
1588	Multidrug resistance protein 1	ABCB1	0.0331
6824	Tyrosine-protein kinase Lyn	LYN	0.033
611	Retinal dehydrogenase 1	ALDH1A1	0.0328
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0327
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0326
4275	PCZA361.16	Not Available	0.0326
4276	DNA polymerase III subunit epsilon	dnaQ	0.0326
1275	Estrogen sulfotransferase	SULT1E1	0.0323
1192	Sulfotransferase 1A1	SULT1A1	0.0322
3759	Glutathione S-transferase	gst	0.032
4541	Glutathione S-transferase	GST	0.032
2929	(S)-2-haloacid dehalogenase	dhlB	0.032
2995	(S)-2-haloacid dehalogenase	Not Available	0.032
4542	Glutaminase 1	glsA1	0.032
4544	Glutaminase 1	glsA1	0.032
4528	Phenazine biosynthesis protein PhzD	phzD1	0.032
56	Delta-aminolevulinic acid dehydratase	ALAD	0.032
2356	Delta-aminolevulinic acid dehydratase	hemB	0.032
3613	Delta-aminolevulinic acid dehydratase	hemB	0.032
3674	Delta-aminolevulinic acid dehydratase	hemB	0.032
3237	Beta-lactamase OXA-2	bla	0.032
4517	Probable butyrate kinase 2	buk2	0.032
4532	Gephyrin	GPHN	0.032
500	Monocarboxylate transporter 4	SLC16A3	0.0319
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0317
909	Maleylacetoacetate isomerase	GSTZ1	0.0317
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0316
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0316
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0316
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0316
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0316
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0316
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0316
2596	Acetyl-CoA acetyltransferase	phbA	0.0315
2599	Tyrosine-protein kinase HCK	HCK	0.0314
3244	Ribonucleoside-diphosphate reductase 2 alpha subunit	nrdE	0.0312
615	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0311
3138	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0311
4568	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0311
6370	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0311
810	Heme oxygenase 1	HMOX1	0.0303
3391	Heme oxygenase 1	pbsA1	0.0303
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0301
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0299
3810	Catechol O-methyltransferase	COMT	0.0297
3467	Methylglyoxal synthase	mgsA	0.0295
2633	Anaerobic ribonucleoside-triphosphate reductase	NRDD	0.0294
543	Penicillin-binding protein 1B	mrcB	0.029
6186	Penicillin-binding protein 1B	ponB	0.029
6822	Penicillin-binding protein 1b	pbp1b	0.029
6844	Penicillin-binding protein 1b	pbp1b	0.029
1881	Hexokinase-1	HK1	0.0289
6145	Solute carrier family 22 member 1	SLC22A1	0.0286
645	Penicillin-binding protein 1A	mrcA	0.0285
5805	Penicillin-binding protein 1A	ponA	0.0285
6185	Penicillin-binding protein 1A	mrcA	0.0285
6799	Penicillin-binding protein 1A	pbpA	0.0285
2164	Multidrug resistance-associated protein 4	ABCC4	0.0283
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0281
6136	Multidrug resistance-associated protein 5	ABCC5	0.0281
1	Peptidoglycan synthetase ftsI	ftsI	0.028
4155	Peptidoglycan synthetase ftsI	ftsI	0.028
864	Gag-Pol polyprotein	gag-pol	0.0279
2237	Gag-Pol polyprotein	gag-pol	0.0279
2326	Gag-Pol polyprotein	gag-pol	0.0279
2451	Gag-Pol polyprotein	gag-pol	0.0279
2901	Gag-Pol polyprotein	gag-pol	0.0279
3165	Gag-Pol polyprotein	gag-pol	0.0279
3722	Gag-Pol polyprotein	gag-pol	0.0279
6306	Gag-Pol polyprotein	gag-pol	0.0279
6624	Gag-Pol polyprotein	gag-pol	0.0279
159	Penicillin-binding protein 2B	penA	0.0279
6121	Penicillin-binding protein 2B	penA	0.0279
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0279
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0279
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0274
2257	Uridine phosphorylase	udp	0.0273
5132	Uridine phosphorylase	udp	0.0273
6782	Ribosomal protein S6 kinase alpha-1	RPS6KA1	0.0273
199	Monocarboxylate transporter 8	SLC16A2	0.0271
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.027
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0268
2688	Peptide deformylase	def	0.0267
2708	Peptide deformylase	def	0.0267
3004	Peptide deformylase	def	0.0267
4337	Peptide deformylase	def	0.0267
4338	Peptide deformylase	def	0.0267
5368	Peptide deformylase	def	0.0267
5371	Peptide deformylase	def	0.0267
6375	Peptide deformylase	def	0.0267
6378	Peptide deformylase	def	0.0267
6379	Peptide deformylase	def	0.0267
6776	Peptide deformylase	def	0.0267
6900	Peptide deformylase	def	0.0267
6013	Cytochrome P450 2E1	CYP2E1	0.0266
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0265
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0263
2320	Thymidine kinase, cytosolic	TK1	0.0262
3668	Maltose-binding periplasmic protein precursor	malE	0.0262
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0262
504	Mast/stem cell growth factor receptor	KIT	0.025
5189	Trimethylamine dehydrogenase	tmd	0.0248
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0248
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0246
4606	Purine trans deoxyribosylase	ptd	0.0244
4692	A/G-specific adenine glycosylase	mutY	0.0243
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0241
840	Methionine synthase reductase, mitochondrial	MTRR	0.0239
207	Glutathione synthetase	GSS	0.0238
5269	Glutathione synthetase	gshB	0.0238
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0236
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.0233
3027	Streptavidin	Not Available	0.023
3679	MTA/SAH nucleosidase	mtnN	0.0229
3115	Ras-related protein Rab-9	RAB9A	0.0226
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0225
6171	Solute carrier family 28 member 3	SLC28A3	0.0225
4106	Guanylate kinase	GUK1	0.0224
4516	Guanylate kinase	gmk	0.0224
413	Amidophosphoribosyltransferase	PPAT	0.0224
2515	Amidophosphoribosyltransferase	purF	0.0224
3714	Amidophosphoribosyltransferase	purF	0.0224
809	Methionine synthase	MTR	0.0223
2935	Methionine synthase	metH	0.0223
5646	Galactokinase	GALK1	0.0223
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0223
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0223
5302	TrwB	trwB	0.0223
5265	FtsH	ftsH	0.0223
315	Arginase-1	ARG1	0.0222
844	Epidermal growth factor receptor	EGFR	0.0221
4503	NADPH-flavin oxidoreductase	frp	0.0219
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0215
5624	GTPase	rab6	0.0215
3197	GDP-mannose mannosyl hydrolase	nudD	0.0215
5630	ADP-ribosylation factor-like protein 5A	ARL5A	0.0214
5628	Probable GTPase engC	rsgA	0.0214
5618	ADP-ribosylation factor 4	ARF4	0.0214
5627	GDP-mannose 4,6-dehydratase	gca	0.0214
1882	Ras-related C3 botulinum toxin substrate 1	RAC1	0.0214
2170	Transforming protein RhoA	RHOA	0.0214
3366	GTP-binding protein engA	der	0.0214
408	Riboflavin kinase	RFK	0.0212
851	5'-AMP-activated protein kinase subunit beta-2	PRKAB2	0.0212
388	AMP deaminase 1	AMPD1	0.0212
4924	Cytochrome P450 2C8	CYP2C8	0.021
775	Acetyl-CoA carboxylase 2	ACACB	0.0209
6460	Casein kinase I isoform gamma-3	CSNK1G3	0.0207
5312	Kinesin-like protein KIF1A	KIF1A	0.0205
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0205
587	Serum albumin	ALB	0.0204
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0199
1178	Adenosine A2a receptor	ADORA2A	0.0199
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0198
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0195
16	Adenosine A1 receptor	ADORA1	0.0195
4200	Cytochrome P450 1A2	CYP1A2	0.0195
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0194
666	NADP-dependent malic enzyme	ME1	0.0194
2892	Acetylglutamate kinase	argB	0.0194
3550	Acetylglutamate kinase	argB	0.0194
825	Arsenical pump-driving ATPase	ASNA1	0.0194
3435	Arsenical pump-driving ATPase	arsA	0.0194
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0194
2615	Chemotaxis protein cheA	cheA	0.0194
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0191
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0191
5330	General stress protein 69	yhdN	0.0189
4403	Protein iolS	iolS	0.0188
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0188
5322	Oxidoreductase ydhF	ydhF	0.0188
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0188
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0188
5332	MtdA bifunctional protein	mtdA	0.0188
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0188
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0188
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0188
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0188
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0188
1540	Mitogen-activated protein kinase 14	MAPK14	0.0187
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0187
5619	GDP-mannose 4,6 dehydratase	GMDS	0.0187
3396	Elongation factor Tu	tufA	0.0187
5621	Elongation factor Tu	tuf	0.0187
3170	Elongation factor Tu-B	tufB	0.0187
3270	Elongation factor G	fusA	0.0187
3107	Putative GTP pyrophosphokinase	relA	0.0186
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0186
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0185
4318	Siroheme synthase	cysG	0.0185
444	Alcohol dehydrogenase 1B	ADH1B	0.0184
5178	Protein nrdI	nrdI	0.0183
5201	FMN-binding protein	DvMF_2023	0.0183
3957	Adenosine deaminase	ADA	0.0183
5179	Probable aromatic acid decarboxylase	pad1	0.0183
5181	Hypothetical protein yhdA	azr	0.0183
5198	Flavodoxin-1	fldA	0.0183
5170	Epidermin decarboxylase	epiD	0.0183
3293	Flavodoxin	Not Available	0.0183
4614	Flavodoxin	DVU_2680	0.0183
5172	Flavodoxin	isiB	0.0183
5173	Flavodoxin	isiB	0.0183
5182	Flavodoxin	fldA	0.0183
5202	Nitroreductase family protein	BC_1844	0.0183
1830	5'-nucleotidase	NT5E	0.0183
5200	NADH dehydrogenase	nox	0.0183
5193	Phenazine biosynthesis protein phzG	phzG	0.0183
5175	Hypothetical protein SMU.260	SMU_260	0.0183
5197	Trp repressor binding protein WrbA, putative	DR_A0214	0.0183
5131	PhzG	phzG	0.0183
4405	Nitric oxide reductase	fprA	0.0183
2586	Isopentenyl-diphosphate Delta-isomerase	idi	0.0183
5187	Isopentenyl-diphosphate delta-isomerase	fni	0.0183
5199	Isopentenyl-diphosphate delta-isomerase	fni	0.0183
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0183
5191	Morphinone reductase	morB	0.0183
5190	Rubredoxin-oxygen oxidoreductase	roo	0.0183
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0179
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0179
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0179
297	Adenylate cyclase type 1	ADCY1	0.0179
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0179
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0179
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0179
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0177
862	Multidrug resistance-associated protein 1	ABCC1	0.0175
6556	Elongation factor Tu GTP-binding domain-containing protein 1	EFTUD1	0.0172
672	Prostaglandin F2-alpha receptor	PTGFR	0.0171
2538	6-phospho-beta-glucosidase bglT	bglT	0.017
2393	Maltose-6'-phosphate glucosidase	glvA	0.017
4120	NADPH--cytochrome P450 reductase	POR	0.017
6268	Hydroxyacid oxidase 1	HAO1	0.0169
2256	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	0.0168
1729	Solute carrier family 22 member 6	SLC22A6	0.0168
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0167
1291	cAMP response element-binding protein	CREB1	0.0167
291	Nitric-oxide synthase, endothelial	NOS3	0.0166
4582	Putative pteridine reductase 2	ptr2	0.0164
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0164
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0164
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0164
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0164
989	L-xylulose reductase	DCXR	0.0164
3446	NADP-dependent alcohol dehydrogenase	adh	0.0164
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0164
5073	Ferredoxin--NADP reductase	petH	0.0164
5076	Ferredoxin--NADP reductase	fpr	0.0164
5119	Ferredoxin--NADP reductase	petH	0.0164
5121	Ferredoxin--NADP reductase	fpr	0.0164
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0164
2286	Isocitrate dehydrogenase [NADP]	icd	0.0164
2302	Isocitrate dehydrogenase [NADP]	icd	0.0164
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0163
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0163
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0163
6790	Elongation factor 2	EEF2	0.0162
624	Guanidinoacetate N-methyltransferase	GAMT	0.0161
2392	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0161
3032	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0161
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0161
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.016
1998	Protein-L-isoaspartate(D-aspartate) O-methyltransferase	PCMT1	0.0159
2551	Cobalt-precorrin-4 C(11)-methyltransferase	cbiF	0.0159
5206	Phosphopantothenoylcysteine decarboxylase	PPCDC	0.0159
4313	Probable tRNA/rRNA methyltransferase HI0766	trmL	0.0159
4316	Mycolic acid synthase	pcaA	0.0159
4331	Chemotaxis protein methyltransferase	cheR	0.0159
4323	Modification methylase HhaI	hhaIM	0.0159
4314	Modification methylase PvuII	pvuIIM	0.0159
3680	Dihydroorotate dehydrogenase A	pyrDA	0.0159
3724	Protein methyltransferase hemK	hemK	0.0159
4329	Uroporphyrinogen-III C-methyltransferase	cobA	0.0159
3507	Chorismate synthase	aroC	0.0159
5171	Chorismate synthase	aroC	0.0159
4324	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7	SETD7	0.0159
4330	Hypothetical protein TTHA0667	TTHA0667	0.0159
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0159
4315	DNA adenine methylase	DAM	0.0159
5176	YtnJ	moxC	0.0159
4309	S-adenosyl-L-methionine-dependent methyltransferase mraW	rsmH	0.0159
4333	Protein-L-isoaspartate O-methyltransferase	pcm	0.0159
4836	Ferredoxin-dependent glutamate synthase 2	gltS	0.0159
6024	Cytochrome P450 1A1	CYP1A1	0.0159
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0156
465	Calmodulin	CALM1	0.0156
4119	Cytochrome P450 2D6	CYP2D6	0.0156
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0155
394	Calcineurin subunit B isoform 1	PPP3R1	0.0154
6753	Apolipoprotein M	APOM	0.0154
6742	Recoverin	RCVRN	0.0154
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0154
5641	Rod shape-determining protein MreB	TM_0588	0.0154
4178	DNA repair protein RAD51 homolog 1	RAD51	0.0154
6747	Chalcone/stilbene synthase family protein	MT1417	0.0154
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0154
6743	Non-fluorescent flavoprotein	luxF	0.0154
3794	Osmolarity sensor protein envZ	envZ	0.0154
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0154
5644	Sensor protein phoQ	phoQ	0.0154
6751	Gag polyprotein	gag	0.0154
5643	General secretion pathway protein E	epsE	0.0154
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0154
5642	Chaperone clpB	clpB	0.0154
5645	DNA topoisomerase 4 subunit B	parE	0.0154
6227	DNA topoisomerase 4 subunit B	parE	0.0154
5649	Potassium-transporting ATPase B chain	kdpB	0.0154
6749	Polyprotein	Not Available	0.0154
1596	Protein-glutamine gamma-glutamyltransferase 2	TGM2	0.0151
6297	Prostaglandin reductase 1	PTGR1	0.0151
3822	Actin, alpha skeletal muscle	ACTA1	0.0151
3062	Aspartate-semialdehyde dehydrogenase	asd	0.0151
6021	Adenosine kinase	ADK	0.0147
6608	Serine/threonine-protein kinase Sgk1	SGK1	0.0147
4608	Putative cytochrome P450	SCO1207	0.0146
4963	Putative cytochrome P450	SCO2884	0.0146
6254	Putative cytochrome P450	SCO6998	0.0146
2675	Pteridine reductase 1	PTR1	0.0143
1124	Sepiapterin reductase	SPR	0.0143
2516	GMP reductase 1	GMPR	0.0141
2361	Response regulator pleD	pleD	0.0141
4198	Fructose-1,6-bisphosphatase 1	FBP1	0.014
936	Ephrin type-A receptor 2	EPHA2	0.0139
5180	L(+)-mandelate dehydrogenase	mdlB	0.0138
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0138
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0138
2683	Mono-ADP-ribosyltransferase C3	C3	0.0138
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0136
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0136
2632	Adenylosuccinate synthetase	purA	0.0135
3323	Adenylosuccinate synthetase	purA	0.0135
3975	Adenylosuccinate synthetase	ADSS	0.0135
4598	Adenylosuccinate synthetase	Adss	0.0135
6817	Adenylosuccinate synthetase	purA	0.0135
4332	Modification methylase TaqI	taqIM	0.0135
4310	rRNA adenine N-6-methyltransferase	ermC'	0.0135
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0135
4306	HemK protein	TM_0488	0.0135
5961	Insulin	INS	0.0134
6527	Lymphocyte antigen 96	LY96	0.0134
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0134
2397	Dihydroxyacetone kinase	dhaK	0.0134
4751	Mitogen-activated protein kinase 12	MAPK12	0.0134
6755	Poliovirus receptor	PVR	0.0134
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0134
2852	DNA mismatch repair protein mutL	mutL	0.0134
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0133
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0133
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0132
6016	Cytochrome P450 2C19	CYP2C19	0.0132
2159	Quinone oxidoreductase	CRYZ	0.0131
20	Prostaglandin G/H synthase 1	PTGS1	0.0131
3117	Carminomycin 4-O-methyltransferase	dnrK	0.0131
4302	METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2	mmaA2	0.013
2242	Cyclopropane-fatty-acyl-phospholipid synthase 2	cmaA2	0.013
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0128
10	Glycogen phosphorylase, liver form	PYGL	0.0127
1024	Solute carrier family 22 member 11	SLC22A11	0.0127
6085	Fatty acid-binding protein, intestinal	FABP2	0.0125
2653	Modification methylase RsrI	rsrIM	0.0124
4284	Pentaerythritol tetranitrate reductase	onr	0.0124
6524	Protein tonB	tonB	0.0123
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0123
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0123
3231	Death-associated protein kinase 1	DAPK1	0.0123
5626	Nucleoside diphosphate kinase B	NME2	0.0122
6143	Solute carrier family 22 member 7	SLC22A7	0.0121
4327	RdmB	rdmB	0.0121
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.012
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0119
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0119
4057	Glycine N-acyltransferase	GLYAT	0.0119
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0119
4056	N-arachidonyl glycine receptor	GPR18	0.0119
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0119
1466	Glycyl-tRNA synthetase	GARS	0.0119
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0119
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0119
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0119
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0119
365	Dihydrofolate reductase	DHFR	0.0117
2381	Dihydrofolate reductase	DFR1	0.0117
2833	Dihydrofolate reductase	Not Available	0.0117
2931	Dihydrofolate reductase	folA	0.0117
3544	Dihydrofolate reductase	folA	0.0117
3682	Dihydrofolate reductase	folA	0.0117
6642	Dihydrofolate reductase	folA	0.0117
6756	Dihydrofolate reductase	dfrA	0.0117
4609	U1 small nuclear ribonucleoprotein A	SNRPA	0.0117
2616	Ganglioside GM2 activator	GM2A	0.0117
776	Bile salt export pump	ABCB11	0.0116
3175	Glutamate--cysteine ligase	gshA	0.0114
2966	PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase	pyrR	0.0113
338	DNA polymerase	UL30	0.0113
379	DNA polymerase	UL54	0.0113
697	DNA polymerase	ORF28	0.0113
2482	DNA polymerase	43	0.0113
4104	DNA polymerase	BALF5	0.0113
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0111
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0111
816	Biliverdin reductase A	BLVRA	0.0111
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0111
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0111
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0111
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0109
4311	tRNA	TRDMT1	0.0108
4325	tRNA	trmD	0.0108
4328	tRNA	trmD	0.0108
887	DNA gyrase subunit B	gyrB	0.0108
4150	DNA gyrase subunit B	gyrB	0.0108
6225	DNA gyrase subunit B	gyrB	0.0108
3300	Xanthine phosphoribosyltransferase	xpt	0.0107
3681	Xanthine phosphoribosyltransferase	gpt	0.0107
4210	Toll-like receptor 4	TLR4	0.0107
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0105
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0105
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0105
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0104
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0103
597	Dihydropteridine reductase	QDPR	0.0103
328	Sorbitol dehydrogenase	SORD	0.0103
396	Alcohol dehydrogenase 4	ADH4	0.0103
5287	Signaling protein	Not Available	0.0103
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0103
5304	UPF0166 protein TM_0021	TM_0021	0.0103
5288	Shikimate kinase	aroK	0.0103
5293	Shikimate kinase 2	aroL	0.0103
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0103
5292	Putative partitioning protein	TT_C1605	0.0103
5266	Activator of	hgdC	0.0103
4346	Polynucleotide kinase	pseT	0.0103
5281	Plasmid segregation protein parM	parM	0.0103
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0103
2874	Nitrogenase iron protein 1	nifH1	0.0103
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0103
5315	Chaperone protein htpG	htpG	0.0103
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0103
5299	D-alanine--D-alanine ligase	ddl	0.0103
6598	D-alanine--D-alanine ligase	ddl	0.0103
5283	D-alanine--D-alanine ligase B	ddlB	0.0102
5264	DNA replication protein	REP	0.0102
5259	Transcriptional regulator	ntrC1	0.0102
6699	Transcriptional regulator	Cgl2612	0.0102
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0102
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0102
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0102
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0102
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0102
5291	Glycogen synthase 1	glgA1	0.0102
5284	Large T antigen	Not Available	0.0102
5277	Preprotein translocase subunit secA	secA	0.0102
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0102
5285	Kinesin heavy chain	KIF5B	0.0102
5308	Preprotein translocase secA 1 subunit	secA1	0.0102
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0102
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0102
2750	Aspartate 1-decarboxylase	panD	0.0102
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0101
290	Prostaglandin G/H synthase 2	PTGS2	0.0101
6167	Organic solute transporter subunit beta	OSTB	0.0101
6166	Organic solute transporter subunit alpha	OSTA	0.0101
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.01
958	Insulin-like growth factor 1 receptor	IGF1R	0.0099
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0099
5650	NimA-related protein	DR_0842	0.0098
77	L-lactate dehydrogenase B chain	LDHB	0.0097
12	Alcohol dehydrogenase class 3	ADH5	0.0097
2557	Cap-specific mRNA	PAPS	0.0096
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0096
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0096
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0096
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0096
2439	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]	otsA	0.0095
62	Glycine receptor subunit beta	GLRB	0.0095
275	Arachidonate 5-lipoxygenase	ALOX5	0.0095
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0095
473	L-lactate dehydrogenase A chain	LDHA	0.0095
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0094
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0094
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0094
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0093
118	Organic cation/carnitine transporter 2	SLC22A5	0.0092
383	Glycine amidinotransferase, mitochondrial	GATM	0.0092
2284	Adenylate kinase	adk	0.0089
2296	Adenylate kinase	adk	0.0089
2311	Adenylate kinase	adk	0.0089
2312	Adenylate kinase	Not Available	0.0089
2270	Dephospho-CoA kinase	coaE	0.0089
3470	Hypothetical protein MG245 homolog	MPN_348	0.0089
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0089
3426	Glutamine synthetase	glnA	0.0089
3987	Glutamine synthetase	GLUL	0.0089
4774	NTPase P4	Not Available	0.0089
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0089
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0089
4837	Cag-alfa	cag-alfa	0.0089
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0089
4839	DNA polymerase III subunit tau	dnaX	0.0089
4838	PMS1 protein homolog 2	PMS2	0.0089
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0088
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0088
1836	Mitogen-activated protein kinase 10	MAPK10	0.0087
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0087
6148	Multidrug resistance-associated protein 7	ABCC10	0.0086
1898	Cytochrome P450 1B1	CYP1B1	0.0086
2427	Ferrichrome-iron receptor	fhuA	0.0086
569	Retinal dehydrogenase 2	ALDH1A2	0.0086
4989	Cytochrome c551 peroxidase	ccp	0.0086
5222	Cytochrome c551 peroxidase	ccpA	0.0086
4936	Cytochrome c2 iso-2	Not Available	0.0085
4915	Cytochrome c-550	psbV	0.0085
4959	Cytochrome c-550	psbV	0.0085
5216	Cytochrome c-550	psbV	0.0085
3884	SHMT2 protein	SHMT2	0.0085
3901	SHMT2 protein	SHMT2	0.0085
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0085
4954	Soluble cytochrome b558	Not Available	0.0085
3879	Serine hydroxymethyltransferase 2	Not Available	0.0085
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0085
4916	Cyanoglobin	glbN	0.0085
4925	Cytochrome c-type protein SHP	shp	0.0085
4998	Hemoglobin-like protein yjbI	yjbI	0.0085
4934	Cytochrome c-551	nirM	0.0085
5218	Cytochrome c-551	nirM	0.0085
4947	Bacterial hemoglobin	vhb	0.0085
4942	Diheme cytochrome c napB	napB	0.0085
4984	Neuroglobin	NGB	0.0085
4943	Cytochrome c6	petJ	0.0085
3116	Bacterioferritin	bfr	0.0085
4906	Bacterioferritin	bfr	0.0085
4965	Bacterioferritin	bfr	0.0085
4961	Hemophore HasA	hasA	0.0085
4905	Cytochrome c2	Not Available	0.0085
4939	Cytochrome c2	cycA	0.0085
4964	Cytochrome c2	cycA	0.0085
4979	Cytochrome c2	cycA	0.0085
6673	Cytochrome c2	cycA	0.0085
4981	Iron-starvation protein PigA	pigA	0.0085
4971	Nonaheme cytochrome c	hmcA	0.0085
4994	Hemoglobin-like protein HbO	glbO	0.0085
5000	HemO	hemO	0.0085
4935	Cytochrome c-554	cycA1	0.0085
4907	Cytochrome c-L	moxG	0.0085
6865	Cytochrome c-L	moxG	0.0085
4972	P450cin	cinA	0.0085
4960	Putative cytochrome P450-family protein	SCO7417	0.0085
4975	Cytochrome c-556	RPA3973	0.0085
4931	Cytochrome P450 167A1	CYP167A1	0.0085
4910	Cytoglobin	CYGB	0.0085
4976	Apocytochrome f	petA	0.0085
6407	Apocytochrome f	petA	0.0085
4904	Cytochrome c family protein	GSU1996	0.0085
4993	Hydroxylamine oxidoreductase	hao1	0.0085
4909	CooA protein	cooA	0.0085
4999	Cytochrome P450 165B3	CYP165B3	0.0085
4764	Cytochrome P450 165C4	CYP165C4	0.0085
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0085
4937	Cytochrome oxidase subunit II	rcoxA	0.0085
4922	Cytochrome c, putative	SO_4144	0.0085
4903	Methyl-accepting chemotaxis protein	Tar4	0.0085
4952	Catalase/peroxidase	katA	0.0085
3093	Catalase HPII	katE	0.0085
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0085
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0085
489	Monocarboxylate transporter 2	SLC16A7	0.0085
4192	DNA topoisomerase 2-beta	TOP2B	0.0084
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0084
4203	Histamine N-methyltransferase	HNMT	0.0084
974	Phenylethanolamine N-methyltransferase	PNMT	0.0084
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0083
251	Alcohol dehydrogenase 1A	ADH1A	0.0083
349	Serine--pyruvate aminotransferase	AGXT	0.0082
768	FK506-binding protein 1A	FKBP1A	0.0082
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0082
2206	Glucose-6-phosphate isomerase	GPI	0.0082
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0082
2922	Glycerol kinase	glpK	0.0082
5271	Focal adhesion kinase 1	PTK2	0.0082
6228	Nuclear receptor coactivator 1	NCOA1	0.0082
2236	Casein kinase II subunit alpha	CSNK2A1	0.0081
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0081
6030	Cytochrome P450 2B6	CYP2B6	0.0081
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0079
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
340	Apoptotic protease-activating factor 1	APAF1	0.0079
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0078
461	Glycine receptor subunit alpha-3	GLRA3	0.0078
3669	Ribokinase	rbsK	0.0078
820	Glycine receptor subunit alpha-2	GLRA2	0.0077
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0077
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0077
1792	Tissue-type plasminogen activator	PLAT	0.0077
2282	Protein recA	recA	0.0076
2315	Protein recA	recA	0.0076
2332	Protein recA	recA	0.0076
5263	Protein recA	recA	0.0076
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0076
5300	Antigen peptide transporter 1	TAP1	0.0075
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0075
3375	Acidic cytochrome c3	Not Available	0.0074
4948	Cytochrome c-553	Not Available	0.0074
4923	Cytochrome c3	DvMF_2499	0.0074
4945	Cytochrome c3	Not Available	0.0074
4949	Cytochrome c3	DVU_3171	0.0074
4968	Cytochrome c3	cytc3	0.0074
4997	Cytochrome c3	SO_2727	0.0074
5219	Cytochrome c3	cyd	0.0074
2119	Cytochrome b5	CYB5A	0.0074
4990	PpcA	ppcA	0.0074
4385	Cytochrome c'	Not Available	0.0074
4967	Cytochrome c'	cycA	0.0074
5038	Cytochrome c'	Not Available	0.0074
5223	Cytochrome c'	cycP	0.0074
3570	Cytochrome P450 152A1	cypC	0.0074
4902	Nine-heme cytochrome c	Ddes_2038	0.0074
3189	High-molecular-weight cytochrome c	hmcA	0.0074
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0074
4813	Heme oxygenase	hmuO	0.0074
5769	Heme oxygenase	Not Available	0.0074
4289	Cytochrome P450	TT_P0059	0.0074
6262	Cytochrome P450	staP	0.0074
4920	Peroxidase/catalase	katG	0.0074
2915	Sensor protein fixL	fixL	0.0074
4944	Sensor protein fixL	fixL	0.0074
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0074
4988	Sulfite oxidase, mitochondrial	SUOX	0.0074
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0073
2334	Dethiobiotin synthetase	bioD	0.0072
6555	Dethiobiotin synthetase	bioD	0.0072
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0072
788	Creatine kinase M-type	CKM	0.0071
468	Cytochrome P450 4A11	CYP4A11	0.0071
268	Adenosine A2b receptor	ADORA2B	0.0071
6043	Putative G-protein coupled receptor 44	GPR44	0.007
517	Alcohol dehydrogenase 1C	ADH1C	0.007
1714	Mitogen-activated protein kinase 3	MAPK3	0.007
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0069
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0069
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0069
4472	Glucose 1-dehydrogenase	Not Available	0.0069
4428	Redox-sensing transcriptional repressor rex	rex	0.0069
4449	ADP-ribosyltransferase	Not Available	0.0069
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0069
4423	Levodione reductase	lvr	0.0069
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0069
4443	Quinate/shikimate dehydrogenase	ydiB	0.0069
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0069
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0069
4500	L-lactate dehydrogenase 2	ldh2	0.0069
3381	Alcohol dehydrogenase	Not Available	0.0069
4508	Alcohol dehydrogenase	adhA	0.0069
4414	Dehydrogenase	TT_P0035	0.0069
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0069
4507	Alanine dehydrogenase	ald	0.0069
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0069
4455	Glycerol dehydrogenase	gldA	0.0069
4497	Benzyl alcohol dehydrogenase	xylB	0.0069
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0069
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0069
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0069
4487	Transcriptional regulator nadR	nadR	0.0069
4502	Formate dehydrogenase	Not Available	0.0069
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0069
3729	Citrate synthase	gltA	0.0069
4435	L-aspartate dehydrogenase	nadX	0.0069
4467	Alpha-glucosidase, putative	TM_0752	0.0069
4447	Hypothetical protein yhfP	yhfP	0.0069
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0069
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0069
2350	3-isopropylmalate dehydrogenase	leuB	0.0069
3092	3-isopropylmalate dehydrogenase	leuB	0.0069
4418	AGR_L_3209p	AGR_L_3209	0.0069
4451	Vip2Ac	vip2Ac	0.0069
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0069
3670	Soluble cytochrome b562 precursor	cybC	0.0068
3291	Cytochrome c-552	cycA	0.0068
4927	Cytochrome c-552	nrfA	0.0068
4938	Cytochrome c-552	cycA	0.0068
4953	Cytochrome c-552	nrfA	0.0068
5217	Cytochrome c-552	cycM	0.0068
4386	Hemoglobin-like protein HbN	glbN	0.0068
3411	Cytochrome P450 121	cyp121	0.0068
2617	Nitric oxide synthase oxygenase	nos	0.0068
2701	Nitric oxide synthase oxygenase	nos	0.0068
3102	Flavohemoprotein	hmp	0.0068
4969	Flavohemoprotein	hmp	0.0068
6106	Cytochrome P450 2C18	CYP2C18	0.0068
6107	Cytochrome P450 3A7	CYP3A7	0.0068
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0067
833	Organic cation/carnitine transporter 1	SLC22A4	0.0067
6149	Solute carrier family 22 member 10	SLC22A10	0.0066
482	Glycine receptor subunit alpha-1	GLRA1	0.0066
2230	Catalase	CAT	0.0066
3249	Catalase	katA	0.0066
3625	Catalase	katA	0.0066
4539	Catalase	katA	0.0066
4941	Catalase	katB	0.0066
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0066
2091	Endoplasmin	HSP90B1	0.0065
3127	Nitrite reductase	nirS	0.0064
3284	Nitrite reductase	nirS	0.0064
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0064
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0064
48	Pyridoxal kinase	PDXK	0.0064
1422	Serine/threonine-protein kinase 6	AURKA	0.0063
3379	Kinesin-like protein KIF11	KIF11	0.0062
318	Alpha-2A adrenergic receptor	ADRA2A	0.0062
6141	Sodium/bile acid cotransporter	SLC10A1	0.0062
4122	Histone deacetylase 2	HDAC2	0.0061
5126	Arginase	rocF	0.0061
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0061
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0061
605	Fumarate reductase flavoprotein subunit	frdA	0.0061
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0061
3673	Fumarate reductase flavoprotein subunit	fccA	0.0061
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0061
6549	Fumarate reductase flavoprotein subunit	frdA	0.0061
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0061
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.006
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.006
3615	Dihydrodipicolinate reductase	dapB	0.006
3618	Dihydrodipicolinate reductase	dapB	0.006
4462	Dihydrodipicolinate reductase	dapB	0.006
4509	Acetoin(diacetyl) reductase	budC	0.006
4486	Phenol 2-hydroxylase component B	pheA2	0.006
2424	L-lactate dehydrogenase	ldh	0.006
2641	L-lactate dehydrogenase	Not Available	0.006
4437	L-lactate dehydrogenase	ldh	0.006
4442	L-lactate dehydrogenase	ldh	0.006
126	D-lactate dehydrogenase	dld	0.006
3545	D-lactate dehydrogenase	Not Available	0.006
4510	D-lactate dehydrogenase	ldhA	0.006
4498	Ornithine cyclodeaminase	PP3533	0.006
3081	3-dehydroquinate synthase	aroB	0.006
4439	Ferredoxin reductase	bphA4	0.006
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.006
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.006
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.006
4450	Iota toxin component Ia	Not Available	0.006
4477	Dihydrolipoyl dehydrogenase	lpdV	0.006
5077	Dihydrolipoyl dehydrogenase	Not Available	0.006
5117	Dihydrolipoyl dehydrogenase	lpd	0.006
2591	Urocanate hydratase	hutU	0.006
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.006
2336	2,3-diketo-L-gulonate reductase	dlgD	0.006
2967	CDP-paratose 2-epimerase	rfbE	0.006
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.006
2018	Deoxyhypusine synthase	DHPS	0.006
4482	UDP-galactose 4-epimerase	galE	0.006
2507	Diphtheria toxin	Not Available	0.006
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.006
518	Peroxidase/catalase T	katG	0.0059
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0059
556	Alpha-1A adrenergic receptor	ADRA1A	0.0058
260	Cytochrome P450 51	ERG11	0.0058
761	Cytochrome P450 51	ERG11	0.0058
3163	Cytochrome P450 51	cyp51	0.0058
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0058
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0058
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0058
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0058
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0058
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0058
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0058
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0058
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0058
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0057
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0057
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0057
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0057
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0057
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0057
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0057
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0057
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0057
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0057
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0057
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0057
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0057
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0057
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0057
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0057
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0057
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0057
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0057
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0057
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0057
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0057
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0057
206	3-keto-steroid reductase	HSD17B7	0.0057
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0057
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0057
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0057
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0057
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0057
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0057
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0057
167	L-lactate dehydrogenase C chain	LDHC	0.0057
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0057
644	Heme oxygenase 2	HMOX2	0.0057
4982	Heme oxygenase 2	pbsA2	0.0057
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0057
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0057
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0057
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0057
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0057
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0057
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0057
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0057
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0057
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0057
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0057
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0057
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0057
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0057
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0057
643	Peroxisomal bifunctional enzyme	EHHADH	0.0057
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0057
711	UDP-glucose 6-dehydrogenase	UGDH	0.0057
3672	UDP-glucose 6-dehydrogenase	hasB	0.0057
34	7-dehydrocholesterol reductase	DHCR7	0.0057
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0057
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0057
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0057
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0057
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0057
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0057
107	C-4 methylsterol oxidase	SC4MOL	0.0057
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0057
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0057
729	GDP-L-fucose synthetase	TSTA3	0.0057
3463	GDP-L-fucose synthetase	fcl	0.0057
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0057
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0057
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0057
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0057
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0056
1507	Cytochrome c	CYCS	0.0056
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0056
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0055
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0055
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0055
4504	WbpP	Not Available	0.0055
3367	GDP-mannose 6-dehydrogenase	algD	0.0055
4440	NADH peroxidase	npr	0.0055
4343	Alpha-glucosidase	aglA	0.0055
4476	Mannitol dehydrogenase	mtlD	0.0054
63	Malate dehydrogenase	mdh	0.0054
2329	Malate dehydrogenase	mdh	0.0054
3445	Malate dehydrogenase	mdh	0.0054
4420	Malate dehydrogenase	mdh	0.0054
4438	Malate dehydrogenase	mdh	0.0054
693	Hemoglobin subunit beta	HBB	0.0054
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0053
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0052
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0052
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0052
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0052
3070	Adenosylhomocysteinase	AHCY	0.0052
4424	Adenosylhomocysteinase	PFE1050w	0.0052
6278	Adenosylhomocysteinase	ahcY	0.0052
2826	Glucose--fructose oxidoreductase	gfo	0.0052
527	Prostacyclin receptor	PTGIR	0.0052
6144	Solute carrier family 22 member 2	SLC22A2	0.0052
327	Glutathione reductase	gor	0.0052
5110	Glutathione reductase	GR2	0.0052
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0051
33	Cystine/glutamate transporter	SLC7A11	0.0051
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
4773	Deoxycytidine kinase	DCK	0.0049
4491	DNA ligase, NAD-dependent	ligA	0.0048
2300	Lysozyme	E	0.0048
3633	Lysozyme	R	0.0048
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0048
5718	Cytochrome P450 2A6	CYP2A6	0.0048
2298	Cytochrome P450-cam	camC	0.0047
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0047
2762	UDP-glucose 4-epimerase	GALE	0.0047
3461	UDP-glucose 4-epimerase	galE	0.0047
3014	Ribonuclease UK114	HRSP12	0.0046
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0046
5428	Replication protein	repA	0.0046
3617	Non-heme chloroperoxidase	cpo	0.0046
5426	Non-heme chloroperoxidase	cpo	0.0046
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0046
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0046
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0046
3018	HTH-type transcriptional regulator malT	malT	0.0046
626	Cysteine dioxygenase type 1	CDO1	0.0046
6026	Alcohol dehydrogenase 6	ADH6	0.0046
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0045
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0045
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0045
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0045
6147	Solute carrier family 22 member 3	SLC22A3	0.0045
136	Estrogen receptor	ESR1	0.0045
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0044
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0044
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0044
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0044
627	11-cis retinol dehydrogenase	RDH5	0.0044
13	Aminomethyltransferase, mitochondrial	AMT	0.0044
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0044
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0044
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0043
6837	Serine/threonine-protein kinase 17B	STK17B	0.0042
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0042
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0042
492	Histamine H1 receptor	HRH1	0.0041
7	Nitric oxide synthase, inducible	NOS2	0.004
2958	Probable tautomerase ydcE	pptA	0.004
2573	Cocaine esterase	cocE	0.004
7263	Cocaine esterase	Not Available	0.004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0039
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0039
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0039
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0038
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0038
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0038
279	Tyrosinase	TYR	0.0037
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0037
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0035
380	Cytochrome P450 17A1	CYP17A1	0.0035
2216	Fibroblast growth factor receptor 4	FGFR4	0.0034
2240	Cell division protein kinase 2	CDK2	0.0034
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0034
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0033
3969	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase	PAICS	0.0032
799	Aspartyl-tRNA synthetase, cytoplasmic	DARS	0.0032
209	Aspartoacylase	ASPA	0.0032
3979	Aspartoacylase-2	ACY3	0.0032
533	Aminoacylase-1	ACY1	0.0032
3972	Adenylosuccinate synthetase isozyme 2	ADSS	0.0032
3976	Aspartyl-tRNA synthetase, mitochondrial	DARS2	0.0032
513	Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	0.0032
305	Mitochondrial aspartate-glutamate carrier protein	SLC25A13	0.0032
262	Calcium-binding mitochondrial carrier protein Aralar1	SLC25A12	0.0032
3856	Fibroblast growth factor receptor 3	FGFR3	0.0031
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0031
2021	Thrombomodulin	THBD	0.0031
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.003
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.003
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.003
2693	Heat-labile enterotoxin B chain	eltB	0.003
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.003
3971	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	CAD	0.003
5787	Angiopoietin-1 receptor	TEK	0.003
6645	D-amino-acid oxidase	DAO	0.0029
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0029
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0029
6020	Aldehyde oxidase	AOX1	0.0028
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0028
6589	Delta-hemolysin	hld	0.0028
6586	Protein S100-G	S100G	0.0028
6591	ATP synthase C chain	atpH	0.0028
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0028
6587	Rubredoxin	rub	0.0028
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.0028
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.0028
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.0028
6588	Methionyl-tRNA formyltransferase	fmt	0.0028
6593	Immunoglobulin G-binding protein G	spg	0.0028
484	Tyrosine-protein kinase ABL2	ABL2	0.0028
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0027
3977	ASRGL1 protein	ASRGL1	0.0027
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0027
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0027
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0027
3947	Xanthine dehydrogenase/oxidase	XDH	0.0026
823	Fibroblast growth factor receptor 2	FGFR2	0.0026
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0026
3877	Growth-inhibiting protein 18	GIG18	0.0025
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0025
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0025
1671	Excitatory amino acid transporter 3	SLC1A1	0.0025
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0025
3587	Gastrotropin	FABP6	0.0025
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0025
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0025
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0025
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0025
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0025
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0025
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0025
6279	Beta-2-microglobulin	B2M	0.0025
740	Argininosuccinate synthase	ASS1	0.0025
865	Argininosuccinate synthase	ASS1	0.0025
2680	Argininosuccinate synthase	argG	0.0025
3194	Argininosuccinate synthase	argG	0.0025
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0025
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0025
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0025
6559	Cytochrome c oxidase subunit 2	ctaC	0.0025
6669	Cytochrome c oxidase subunit 2	ctaC	0.0025
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0025
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0025
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0025
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0025
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0025
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0025
6558	Cytochrome c oxidase subunit 1	ctaD	0.0025
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0024
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0024
165	FL cytokine receptor	FLT3	0.0024
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0024
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0023
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0023
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0023
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0023
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0023
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0023
6220	Aryl hydrocarbon receptor	AHR	0.0023
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0021
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0021
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0021
407	Vascular endothelial growth factor receptor 2	KDR	0.0021
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0021
273	Apoptosis regulator Bcl-2	BCL2	0.0021
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.002
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.002
284	DNA-directed RNA polymerase beta chain	rpoB	0.002
5773	DNA-directed RNA polymerase beta chain	rpoB	0.002
2132	Protein S100-B	S100B	0.0019
6352	Reaction center protein H chain	puhA	0.0019
6456	Reaction center protein H chain	puhA	0.0019
6682	Reaction center protein H chain	puhA	0.0019
6354	Reaction center protein M chain	pufM	0.0019
6455	Reaction center protein M chain	pufM	0.0019
6684	Reaction center protein M chain	pufM	0.0019
6353	Reaction center protein L chain	pufL	0.0019
6454	Reaction center protein L chain	pufL	0.0019
6683	Reaction center protein L chain	pufL	0.0019
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.0019
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0018
952	Dipeptidyl peptidase 4	DPP4	0.0016
6031	Cytochrome P450 3A43	CYP3A43	0.0016
309	Antithrombin-III	SERPINC1	0.0015
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0015
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0014
756	Sex hormone-binding globulin	SHBG	0.0014
3811	Cytochrome P450 19A1	CYP19A1	0.0014
869	Estrogen receptor beta	ESR2	0.0013

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB04272 - Citric Acid

Targets

Transporters

Predictions