DT-Web

3-oxoacyl-[acyl-carrier-protein] synthase 3


Partner ID 3138
Name 3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms 5188
Gene name fabH
General function Lipid transport and metabolism
Specific function Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for long chain acyl-CoA such as myristoyl-CoA. Does not use acyl-CoA as primer. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall
Gene sequence + ...

TCAACCCTTCGGCATTCGCACCACCTGGGCGGCATAGCTCAGACCGGCGCCGTAGCCGATCAACAGGGCCAGATCGCCGGGCTTGGCCGCGCCGGTCGTCAGTAATTCGGCCATCGCGAGCGGAATGGAGGCCGCCGAGGTGTTTCCGGTGTGCTCGATATCGTTGGCGACCACCGCGTCGGGCCGCAACTGCAGGTTCTTGACCAGCAGCTCGTTGATGCGGCTATTGGCCTGATGAGGGACGAACACGTCTATCTGGTCGGGTCGCACCCCGGCGGCGTCCATCGCGCGCCGACCGACGTCGCCCATTTTGAACGCTGCCCAACGGAAGACCGCGGGACCTTCGAGCCGCACAAACGGGCGTGGGCCGCTGGGATTCTGGGCGAAAGTGATCCAGTCGATGTCCTGCCGTATGGCATCGGCCTGTTCGCCGTCGCTACCCGCCACGGTTGGTCCAATGCCTTGAAACGGTGTCTCGCCCACCACCACTGCGGCCGCGCCGTCGGCGAAGATGAAGCAGTTGCCGCGGTCGTACATGTCTATCGTGGGGGACAGTTTTTCCGTGCCGACCACCAGCATCGTGGCCGCACCTCCGCCCCGGATCATGTCGGCCGCTGCGCCAAGCGCATATCCGAATCCGGCGCACCCCGCCGAAAGATCGAACCCGAGTATGCCCTTGGCGCCCAGCGACGCCGCGACCATTGGGGCGGCCGGCGGGGTTTGCAGGAAATGGGTGTTGGTGGTGACGATCACGCCATCGATGTCGGCCGCCGACAGGCCGGCGTTCGACAGTGCCCGTCGACAGGCCTCAGTCGCCATGGAAGCCGCCGACTCGTCGTCGGCGGCGAATCGGCGGGTCTTGATGCCGGTTCGGGTGTAGATCCACTCGTCGGACGAGTCGATGTGCTGGCATATCTCGTCGTTGGTGACCACGCGTTCGGGCCGGTACGCCCCGACACTGAGCAGCCCGACGCTCCTGGCGCCGCTGGTCGTGGCGATCTCCGTCAT
Protein sequence + ...

MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
GO Classification
function
fatty-acid synthase activity
3-oxoacyl-[acyl-carrier protein] synthase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring groups other than amino-acyl groups
acyltransferase activity
process
organic acid metabolism
carboxylic acid metabolism
fatty acid metabolism
fatty acid biosynthesis
physiological process
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB03264 Dodecyl-Coa
DB07611 DECANE-1-THIOL
DB07650 DECYL FORMATE
DB08171 11-MERCAPTOUNDECANOIC ACID
DB08684 O-DECYL HYDROGEN THIOCARBONATE
DB08712 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID

Associated as Prediction

Id Name
DB00157 NADH
DB00175 Pravastatin
DB00227 Lovastatin
DB00417 Penicillin V
DB00439 Cerivastatin
DB00583 L-Carnitine
DB00641 Simvastatin
DB00684 Tobramycin
DB01034 Cerulenin
DB01076 Atorvastatin
DB01083 Orlistat
DB01095 Fluvastatin
DB01098 Rosuvastatin
DB01133 Tiludronate
DB01172 Kanamycin
DB01669 Virginiamycin M1
DB01734 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
DB01764 Dalfopristin
DB01769 Double Oxidized Cysteine
DB01783 Pantothenic acid
DB01820 Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-Napthylalaniamide
DB01822 Dithiane Diol
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01846 Oxidized Coenzyme A
DB01856 Pimelic Acid
DB01862 1-(Isopropylthio)-Beta-Galactopyranside
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01915 S-Hydroxycysteine
DB01992 Coenzyme A
DB02014 Compound 9
DB02039 S-Acetyl-Cysteine
DB02072 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid
DB02160 S-Butyryl-Cystein
DB02175 Malonic acid
DB02259 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide
DB02316 1-(5-Carboxypentyl)-5-[(2,6-Dichlorobenzyl)Oxy]-1 H-Indole-2-Carboxylic Acid
DB02321 5-(3-Amino-4,4-Dihyroxy-Butylsulfanylmethyl)-Tetrahydro-Furan-2,3,4-Triol
DB02420 [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,
DB02436 2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid
DB02516 O5'-(4-(3-{2-[2-((R)-3-Hydroxy-4-(Trimethylammonio)-1-Oxo-Butyl)Sulfanyl-Ethylcarbamoyl]-Ethylcarbamoyl}-(R)-3-Hydroxy-2,2-Dimethyl-Propyl)-1-Hydroxy-3-Oxido-1,3-Dioxo-2,4-Dioxa-1,3-Diphosphabut-1-Yl) 3'-Phospho-Adenosine
DB02615 Compound 19
DB02620 Sp7343-Sp7964
DB02622 2-(Oxalyl-Amino)-Benzoic Acid
DB02632 1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose
DB02648 (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium
DB02651 {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)
DB02662 Novo Nordisk a/S Compound
DB02784 N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid
DB02827 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
DB02977 PNU177836
DB03045 Pantothenyl-Aminoethanol-Acetate Pivalic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03102 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
DB03134 2-Aminopimelic Acid
DB03154 {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
DB03169 (S)-Hmg-Coa
DB03170 Dephospho Coenzyme A
DB03230 Adenosine-5'-Propylphosphate
DB03264 Dodecyl-Coa
DB03278 D-Treitol
DB03311 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
DB03397 Uridine-Diphosphate-N-Acetylglucosamine
DB03431 Adenosine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03483 4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid
DB03499 Malate Ion
DB03518 (R)-Mevalonate
DB03557 N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid
DB03566 Spermidine
DB03600 Decanoic Acid
DB03613 4-Hydroxyphenacyl Coenzyme A
DB03615 Ribostamycin
DB03661 Cysteinesulfonic Acid
DB03670 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
DB03674 Methyl Mercury Ion
DB03699 Succinyl-Coenzyme A
DB03714 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid
DB03785 (3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03905 Succinamide-Coa
DB03912 4'-Phosphopantetheine
DB03940 Oxamic Acid
DB03982 Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
DB04001 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
DB04067 4-Hydroxybenzyl Coenzyme A
DB04088 N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)
DB04142 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide
DB04182 (S)-2-Amino-4-[(2s,3r)-2,3,5-Trihydroxy-4-Oxo-Pentyl]Mercapto-Butyric Acid
DB04204 [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
DB04242 P-Hydroxybenzoic Acid
DB04272 Citric Acid
DB04285 {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
DB04302 4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One
DB04343 Glyoxalate, Glyoxylate
DB04377 3-Hydroxy-3-Methyl-Glutaric Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04422 2-Amino-4-Mercapto-Butyric Acid
DB04447 1,4-Dithiothreitol
DB04457 2'-Deoxyguanosine-5'-Monophosphate
DB04519 Caprylic acid
DB04524 Malonyl-Coenzyme A
DB04525 2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid
DB04800 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID
DB06693 Mevastatin
DB06829 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID
DB06846 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
DB06887 3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
DB07130 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
DB07134 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
DB07197 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
DB07263 [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
DB07289 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID
DB07295 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
DB07298 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
DB07429 2-({[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl}amino)benzoic acid
DB07477 BIPHENYL-4-YL-ACETALDEHYDE
DB07480 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
DB07611 DECANE-1-THIOL
DB07650 DECYL FORMATE
DB07651 N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
DB07719 3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
DB07730 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
DB08001 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID
DB08003 ISOTHIAZOLIDINONE ANALOG
DB08120 6,8-DIMERCAPTO-OCTANOIC ACID AMIDE
DB08147 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
DB08171 11-MERCAPTOUNDECANOIC ACID
DB08186 (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
DB08291 N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
DB08328 PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACID
DB08359 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE
DB08366 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid
DB08371 PARA-(BENZOYL)-PHENYLALANINE
DB08397 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
DB08407 PLATENSIMYCIN
DB08408 (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoate
DB08549 (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
DB08591 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
DB08593 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
DB08627 (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
DB08628 (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
DB08684 O-DECYL HYDROGEN THIOCARBONATE
DB08712 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID
DB08783 (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
DB08860 Pitavastatin
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