DT-Web

DB00439 - Cerivastatin


Identification
Name Cerivastatin
Accession Number DB00439 (APRD00102)
Type small molecule
Description On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal Rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 459.5503
Groups withdrawn
Monoisotopic Weight 459.242101408
Pharmacology
Indication Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate.
Mechanism of action Cerivastatin competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the hepatic enzyme responsible for converting HMG-CoA to mevalonate. As mevalonate is a precursor of sterols such as cholesterol, this results in a decrease in cholesterol in hepatic cells, upregulation of LDL-receptors, and an increase in hepatic uptake of LDL-cholesterol from the circulation.
Absorption The mean absolute oral bioavailability 60% (range 39 - 101%).
Protein binding More than 99% of the circulating drug is bound to plasma proteins (80% to albumin).
Biotransformation Hepatic. Biotransformation pathways for cerivastatin in humans include the following: demethylation of the benzylic methyl ether to form Ml and hydroxylation of the methyl group in the 6'-isopropyl moiety to form M23.
Route of elimination Not Available
Toxicity Rhabdomyolysis, liver concerns
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bezafibrate Increased risk of myopathy/rhabdomyolysis
Bosentan Bosentan may decrease the serum concentration of cerivastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cerivastatin if bosentan is initiated, discontinued or dose changed.
Clarithromycin The macrolide, clarithromycin, may increase the toxicity of the statin, cerivastatin.
Colchicine Increased risk of rhabdomyolysis with this combination
Cyclosporine Possible myopathy and rhabdomyolysis
Diltiazem Diltiazem may increase the serum concentration of cerivastatin. Cerivastatin may increase the serum concentration of diltiazem. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Erythromycin The macrolide, erythromycin, may increase the toxicity of the statin, cerivastatin.
Fenofibrate Increased risk of myopathy/rhabdomyolysis
Gemfibrozil Increased risk of myopathy/rhabdomyolysis
Imatinib Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of cerivastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cerivastatin if imatinib is initiated, discontinued or dose changed.
Itraconazole Increased risk of myopathy/rhabdomyolysis
Josamycin The macrolide, josamycin, may increase the toxicity of the statin, cerivastatin.
Ketoconazole Increased risk of myopathy/rhabdomyolysis
Nefazodone Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of cerivastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cerivastatin if nefazodone is initiated, discontinued or dose changed.
Quinupristin This combination presents an increased risk of toxicity
Rifabutin Rifabutin may decrease the effect of cerivastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of cerivastatin if rifabutin is initiated, discontinued or dose changed.
Rifampin Rifampin may decrease the effect of cerivastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of cerivastatin if rifampin is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly increase serum levels of this product.

Targets


3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name HMGCR
Pharmacological action yes
Actions inhibitor
References
  • Shiomi M, Ito T: Effect of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits. Br J Pharmacol. 1999 Feb;126(4):961-8. - Pubmed
  • Blumenthal RS: Statins: effective antiatherosclerotic therapy. Am Heart J. 2000 Apr;139(4):577-83. - Pubmed
  • Ganne F, Vasse M, Beaudeux JL, Peynet J, Francois A, Mishal Z, Chartier A, Tobelem G, Vannier JP, Soria J, Soria C: Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes--a possible protective mechanism against atherothrombosis. Thromb Haemost. 2000 Oct;84(4):680-8. - Pubmed
  • Wong WW, Tan MM, Xia Z, Dimitroulakos J, Minden MD, Penn LZ: Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. Clin Cancer Res. 2001 Jul;7(7):2067-75. - Pubmed
  • Denoyelle C, Vasse M, Korner M, Mishal Z, Ganne F, Vannier JP, Soria J, Soria C: Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis. 2001 Aug;22(8):1139-48. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3914

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. - Pubmed
  • Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Boberg M, Angerbauer R, Fey P, Kanhai WK, Karl W, Kern A, Ploschke J, Radtke M: Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved. Drug Metab Dispos. 1997 Mar;25(3):321-31. - Pubmed
  • Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ: Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1352-6. - Pubmed
DTHybrid score 0.9574
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.5624
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.4276
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ: Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1352-6. - Pubmed
DTHybrid score 0.5279
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
DTHybrid score 0.6395
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
DTHybrid score 0.587
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor,inducer
References
  • Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.6749
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4207

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score 0.6606
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score 0.315
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score 0.3482
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
  • Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. - Pubmed
DTHybrid score 0.329

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3929
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.3914
6013 Cytochrome P450 2E1 CYP2E1 0.2118
587 Serum albumin ALB 0.1734
6024 Cytochrome P450 1A1 CYP1A1 0.173
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1632
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1556
862 Multidrug resistance-associated protein 1 ABCC1 0.1516
5718 Cytochrome P450 2A6 CYP2A6 0.1483
20 Prostaglandin G/H synthase 1 PTGS1 0.1287
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1124
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1046
776 Bile salt export pump ABCB11 0.1023
1729 Solute carrier family 22 member 6 SLC22A6 0.0997
6106 Cytochrome P450 2C18 CYP2C18 0.0982
492 Histamine H1 receptor HRH1 0.096
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0937
6145 Solute carrier family 22 member 1 SLC22A1 0.0901
824 Sodium-dependent serotonin transporter SLC6A4 0.0871
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0858
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0831
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0828
2164 Multidrug resistance-associated protein 4 ABCC4 0.0824
1898 Cytochrome P450 1B1 CYP1B1 0.078
6144 Solute carrier family 22 member 2 SLC22A2 0.0735
6142 Solute carrier family 22 member 8 SLC22A8 0.0725
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0696
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0694
4604 Liver carboxylesterase 1 CES1 0.0684
3811 Cytochrome P450 19A1 CYP19A1 0.0665
831 D(2) dopamine receptor DRD2 0.0628
502 5-hydroxytryptamine 2A receptor HTR2A 0.0622
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0612
731 HIV-1 protease HIV-1 protease 0.0611
556 Alpha-1A adrenergic receptor ADRA1A 0.0608
847 Mu-type opioid receptor OPRM1 0.0607
118 Organic cation/carnitine transporter 2 SLC22A5 0.0595
290 Prostaglandin G/H synthase 2 PTGS2 0.0586
136 Estrogen receptor ESR1 0.057
6143 Solute carrier family 22 member 7 SLC22A7 0.0567
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0564
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0527
70 Type-1 angiotensin II receptor AGTR1 0.0498
6148 Multidrug resistance-associated protein 7 ABCC10 0.0493
6031 Cytochrome P450 3A43 CYP3A43 0.0488
320 5-hydroxytryptamine 1A receptor HTR1A 0.0487
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0487
713 Sodium-dependent dopamine transporter SLC6A3 0.0478
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0478
871 Glucocorticoid receptor NR3C1 0.0476
817 DNA topoisomerase 2-alpha TOP2A 0.047
467 Delta-type opioid receptor OPRD1 0.0469
6141 Sodium/bile acid cotransporter SLC10A1 0.0468
766 Beta-2 adrenergic receptor ADRB2 0.0462
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0441
696 Kappa-type opioid receptor OPRK1 0.044
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0437
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0428
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0421
6147 Solute carrier family 22 member 3 SLC22A3 0.042
468 Cytochrome P450 4A11 CYP4A11 0.0419
4589 3-hydroxy-3-methylglutaryl CoA synthase mvaS 0.0417
1024 Solute carrier family 22 member 11 SLC22A11 0.0414
260 Cytochrome P450 51 ERG11 0.0411
761 Cytochrome P450 51 ERG11 0.0411
3163 Cytochrome P450 51 cyp51 0.0411
318 Alpha-2A adrenergic receptor ADRA2A 0.0405
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0392
632 Alpha-1B adrenergic receptor ADRA1B 0.0388
590 5-hydroxytryptamine 2C receptor HTR2C 0.0388
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0385
6137 Multidrug resistance-associated protein 6 ABCC6 0.0383
193 Beta-1 adrenergic receptor ADRB1 0.0382
504 Mast/stem cell growth factor receptor KIT 0.0377
833 Organic cation/carnitine transporter 1 SLC22A4 0.0367
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0359
23 D(1A) dopamine receptor DRD1 0.0359
844 Epidermal growth factor receptor EGFR 0.0359
6182 Cytochrome P450 2J2 CYP2J2 0.0358
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0351
3941 Amine oxidase [flavin-containing] A MAOA 0.0351
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0346
341 5-hydroxytryptamine 3 receptor HTR3A 0.0345
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0341
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0338
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0337
465 Calmodulin CALM1 0.0335
6136 Multidrug resistance-associated protein 5 ABCC5 0.0333
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0332
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0329
614 Progesterone receptor PGR 0.0324
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0318
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0313
638 D(3) dopamine receptor DRD3 0.0312
26 Vascular endothelial growth factor receptor 3 FLT4 0.0311
4120 NADPH--cytochrome P450 reductase POR 0.0304
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0301
32 Vascular endothelial growth factor receptor 1 FLT1 0.0298
3923 Cholinesterase BCHE 0.0297
407 Vascular endothelial growth factor receptor 2 KDR 0.0293
122 P2Y purinoceptor 12 P2RY12 0.0288
885 5-hydroxytryptamine 1B receptor HTR1B 0.0285
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0284
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0281
146 Androgen receptor AR 0.0281
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.028
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0279
228 Beta platelet-derived growth factor receptor PDGFRB 0.0279
29 Tubulin beta-1 chain TUBB1 0.0275
738 Monocarboxylate transporter 1 SLC16A1 0.0274
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0273
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0271
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0269
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0268
6220 Aryl hydrocarbon receptor AHR 0.0266
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0256
1353 DNA topoisomerase 1 TOP1 0.0256
3552 DNA topoisomerase 1 topA 0.0256
789 Alpha-1D adrenergic receptor ADRA1D 0.0245
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0243
725 5-hydroxytryptamine 1D receptor HTR1D 0.0242
737 Mineralocorticoid receptor NR3C2 0.0241
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0241
756 Sex hormone-binding globulin SHBG 0.024
3939 Amine oxidase [flavin-containing] B MAOB 0.024
33 Cystine/glutamate transporter SLC7A11 0.024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0238
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0237
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0234
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.023
161 Tubulin beta chain TUBB 0.0223
312 Tubulin beta chain TUB2 0.0223
477 DNA topoisomerase 4 subunit A parC 0.0223
886 DNA topoisomerase 4 subunit A parC 0.0223
6226 DNA topoisomerase 4 subunit A parC 0.0223
404 DNA gyrase subunit A gyrA 0.0219
6224 DNA gyrase subunit A gyrA 0.0219
4148 Serine/threonine-protein kinase mTOR MTOR 0.0218
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0218
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0216
380 Cytochrome P450 17A1 CYP17A1 0.0214
869 Estrogen receptor beta ESR2 0.0214
811 Translocator protein TSPO 0.0212
891 Dihydropteroate synthase folP 0.0212
5359 Dihydropteroate synthase folP 0.0212
7175 Dihydropteroate synthase sulI 0.0212
2539 Tubulin alpha-1 chain TUBA4A 0.0211
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
275 Arachidonate 5-lipoxygenase ALOX5 0.021
629 Alpha-2B adrenergic receptor ADRA2B 0.0208
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0207
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0205
952 Dipeptidyl peptidase 4 DPP4 0.0201
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0201
1630 Integrin beta-2 ITGB2 0.02
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0194
1757 Myeloperoxidase MPO 0.0192
378 Alpha-2C adrenergic receptor ADRA2C 0.0191
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0191
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0188
432 D(4) dopamine receptor DRD4 0.0186
124 Histamine H2 receptor HRH2 0.0184
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0183
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0183
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0183
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0182
3947 Xanthine dehydrogenase/oxidase XDH 0.0179
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0178
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0177
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0177
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0177
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0177
777 Tumor necrosis factor TNF 0.0175
373 Transthyretin TTR 0.0175
165 FL cytokine receptor FLT3 0.0173
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0173
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0171
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0171
818 50S ribosomal protein L10 rplJ 0.0167
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0167
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0167
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0167
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0167
232 Corticosteroid-binding globulin SERPINA6 0.0166
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0165
1010 Cytochrome P450 51A1 CYP51A1 0.0163
436 5-hydroxytryptamine 2B receptor HTR2B 0.0161
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0161
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0161
13 Aminomethyltransferase, mitochondrial AMT 0.0161
1656 CYP2B protein CYP2B 0.016
716 5-hydroxytryptamine 7 receptor HTR7 0.016
117 Sterol O-acyltransferase 1 SOAT1 0.0159
4773 Deoxycytidine kinase DCK 0.0157
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0156
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0156
365 Dihydrofolate reductase DHFR 0.0156
2381 Dihydrofolate reductase DFR1 0.0156
2833 Dihydrofolate reductase Not Available 0.0156
2931 Dihydrofolate reductase folA 0.0156
3544 Dihydrofolate reductase folA 0.0156
3682 Dihydrofolate reductase folA 0.0156
6642 Dihydrofolate reductase folA 0.0156
6756 Dihydrofolate reductase dfrA 0.0156
3587 Gastrotropin FABP6 0.0155
24 Thymidylate synthase TMP1 0.0154
359 Thymidylate synthase TYMS 0.0154
2626 Thymidylate synthase thyA 0.0154
2729 Thymidylate synthase thyA 0.0154
5352 Thymidylate synthase THYA 0.0154
94 5-hydroxytryptamine 4 receptor HTR4 0.0154
427 Substance-P receptor TACR1 0.0154
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0154
4122 Histone deacetylase 2 HDAC2 0.0153
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
1852 Microtubule-associated protein 2 MAP2 0.0149
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0149
6044 Serum paraoxonase/lactonase 3 PON3 0.0149
6085 Fatty acid-binding protein, intestinal FABP2 0.0148
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0147
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0145
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0145
904 Glutathione S-transferase P GSTP1 0.0144
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0143
174 Sigma 1-type opioid receptor SIGMAR1 0.0143
908 Glutathione S-transferase theta-1 GSTT1 0.0143
6020 Aldehyde oxidase AOX1 0.014
572 Integrin alpha-L ITGAL 0.0139
131 Synaptic vesicular amine transporter SLC18A2 0.0139
474 Acetylcholinesterase ACHE 0.0137
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0137
6102 Arylamine N-acetyltransferase 2 NAT2 0.0137
1192 Sulfotransferase 1A1 SULT1A1 0.0136
273 Apoptosis regulator Bcl-2 BCL2 0.0136
5923 Microtubule-associated protein tau MAPT 0.0134
5924 Microtubule-associated protein 4 MAP4 0.0134
469 Annexin A1 ANXA1 0.0133
758 Thyroid hormone receptor alpha THRA 0.0132
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0131
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0131
6146 High affinity copper uptake protein 1 SLC31A1 0.0131
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.013
2808 Chloramphenicol acetyltransferase 3 cat3 0.013
768 FK506-binding protein 1A FKBP1A 0.0128
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0124
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0124
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0123
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0123
6599 HTH-type transcriptional regulator ttgR ttgR 0.0121
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.012
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
6167 Organic solute transporter subunit beta OSTB 0.0118
705 Glutamate receptor 1 GRIA1 0.0118
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0118
6166 Organic solute transporter subunit alpha OSTA 0.0118
346 Thyroid hormone receptor beta-1 THRB 0.0117
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0117
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0117
3856 Fibroblast growth factor receptor 3 FGFR3 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
6014 Cytochrome P450 2A13 CYP2A13 0.0114
3810 Catechol O-methyltransferase COMT 0.0114
163 D(1B) dopamine receptor DRD5 0.0114
5880 Thrombopoietin receptor MPL 0.0114
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0113
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0113
1618 High affinity nerve growth factor receptor NTRK1 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
1629 Transcription factor AP-1 JUN 0.0111
3809 Estrogen-related receptor gamma ESRRG 0.0111
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0111
1256 5-hydroxytryptamine 6 receptor HTR6 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
84 Nuclear receptor 0B1 NR0B1 0.0109
1650 Heme carrier protein 1 SLC46A1 0.0109
5787 Angiopoietin-1 receptor TEK 0.0108
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0108
2443 Azurin azu 0.0108
5300 Antigen peptide transporter 1 TAP1 0.0108
295 Carbonic anhydrase 1 CA1 0.0108
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0107
823 Fibroblast growth factor receptor 2 FGFR2 0.0107
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0107
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0106
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0105
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0103
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0103
6163 Copper-transporting ATPase 2 ATP7B 0.0103
6165 Copper-transporting ATPase 1 ATP7A 0.0103
528 5-hydroxytryptamine 1E receptor HTR1E 0.0102
482 Glycine receptor subunit alpha-1 GLRA1 0.0101
319 Opioid receptor, sigma 1 OPRS1 0.0101
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.01
594 Thyroxine-binding globulin SERPINA7 0.01
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
511 5-hydroxytryptamine 1F receptor HTR1F 0.0098
921 Glutamate receptor 2 GRIA2 0.0098
239 Coagulation factor X F10 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
896 Glutathione S-transferase Mu 1 GSTM1 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0096
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0096
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0096
4203 Histamine N-methyltransferase HNMT 0.0096
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0096
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0096
49 Endothelin B receptor EDNRB 0.0096
4237 50S ribosomal protein L22 rplV 0.0095
563 Thyroid peroxidase TPO 0.0095
1760 Aminopeptidase N ANPEP 0.0095
6843 Aminopeptidase N pepN 0.0095
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0094
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0094
68 Cannabinoid receptor 1 CNR1 0.0094
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0094
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0092
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0092
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0091
611 Retinal dehydrogenase 1 ALDH1A1 0.0091
183 Vascular endothelial growth factor A VEGFA 0.0091
4192 DNA topoisomerase 2-beta TOP2B 0.009
578 Endothelin-1 receptor EDNRA 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0088
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0088
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0088
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0088
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
3932 Glutathione S-transferase A2 GSTA2 0.0087
1050 Bile salt sulfotransferase SULT2A1 0.0087
357 Carbonic anhydrase 2 CA2 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
284 DNA-directed RNA polymerase beta chain rpoB 0.0086
5773 DNA-directed RNA polymerase beta chain rpoB 0.0086
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0086
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0085
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0085
6149 Solute carrier family 22 member 10 SLC22A10 0.0085
88 Retinoic acid receptor RXR-beta RXRB 0.0085
1178 Adenosine A2a receptor ADORA2A 0.0085
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
814 Ryanodine receptor 1 RYR1 0.0083
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0083
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0083
7 Nitric oxide synthase, inducible NOS2 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0081
1196 Complement decay-accelerating factor CD55 0.008
2449 Tubulin alpha-3 chain TUBA1A 0.008
1525 Heparin-binding growth factor 2 FGF2 0.008
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0079
2636 Shikimate dehydrogenase aroE 0.0079
3515 Shikimate dehydrogenase aroE 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0076
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0075
558 Solute carrier family 12 member 1 SLC12A1 0.0075
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0075
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0075
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0075
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0075
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0074
3917 Methylenetetrahydrofolate reductase MTHFR 0.0074
1541 Metalloproteinase mmp20 0.0074
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0073
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0073
936 Ephrin type-A receptor 2 EPHA2 0.0071
54 Prothrombin F2 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
856 Vitamin D3 receptor VDR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
537 ATP synthase delta chain, mitochondrial ATP5D 0.007
780 Retinoic acid receptor RXR-gamma RXRG 0.007
5626 Nucleoside diphosphate kinase B NME2 0.0068
16 Adenosine A1 receptor ADORA1 0.0068
3086 Plasmepsin-2 Not Available 0.0068
106 Cannabinoid receptor 2 CNR2 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
6432 Transporter snf 0.0067
751 Potassium channel subfamily K member 6 KCNK6 0.0067
4311 tRNA TRDMT1 0.0067
4325 tRNA trmD 0.0067
4328 tRNA trmD 0.0067
267 Plasminogen activator inhibitor 1 SERPINE1 0.0066
976 Platelet glycoprotein IX GP9 0.0066
5669 50S ribosomal protein L27 rpmA 0.0066
5675 Chaperone protein torD torD 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
1517 Beta-3 adrenergic receptor ADRB3 0.0065
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0064
5294 Nucleoside diphosphate kinase A NME1 0.0064
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
199 Monocarboxylate transporter 8 SLC16A2 0.0063
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0063
133 Dihydropterate synthase sulI 0.0063
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0063
6168 Solute carrier family 22 member 16 SLC22A16 0.0063
3270 Elongation factor G fusA 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
172 Potassium channel subfamily K member 1 KCNK1 0.0061
153 Dopamine beta-hydroxylase DBH 0.0061
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
6221 Steroid hormone receptor ERR1 ESRRA 0.006
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.006
162 Retinoic acid receptor gamma-1 RARG 0.006
518 Peroxidase/catalase T katG 0.006
6126 Carbonic anhydrase 7 CA7 0.006
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0059
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0059
2232 Interleukin-5 IL5 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
1593 Mucin-2 MUC2 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0059
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
2285 Streptogramin A acetyltransferase vatD 0.0059
2599 Tyrosine-protein kinase HCK HCK 0.0058
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0058
6824 Tyrosine-protein kinase Lyn LYN 0.0058
909 Maleylacetoacetate isomerase GSTZ1 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0057
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0057
3191 Histidinol dehydrogenase hisD 0.0057
293 Gamma-glutamyl hydrolase GGH 0.0057
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
489 Monocarboxylate transporter 2 SLC16A7 0.0055
702 UMP-CMP kinase CMPK1 0.0055
6506 Stathmin-4 STMN4 0.0055
1275 Estrogen sulfotransferase SULT1E1 0.0054
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0054
1864 RET proto-oncogene RET 0.0054
6837 Serine/threonine-protein kinase 17B STK17B 0.0054
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0054
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0054
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0054
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0054
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0053
2216 Fibroblast growth factor receptor 4 FGFR4 0.0053
4811 Amylosucrase ams 0.0053
2280 Listeriolysin regulatory protein prfA 0.0052
5934 Cytochrome P450 26A1 CYP26A1 0.0052
551 Carnitine O-acetyltransferase CRAT 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0052
191 Peptide methionine sulfoxide reductase MSRA 0.0052
1992 Vitamin D-binding protein GC 0.0052
6043 Putative G-protein coupled receptor 44 GPR44 0.0052
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
4217 Telomerase reverse transcriptase TERT 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
5798 Mitogen-activated protein kinase 11 MAPK11 0.0051
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.005
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.005
569 Retinal dehydrogenase 2 ALDH1A2 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0049
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
173 Toll-like receptor 7 TLR7 0.0049
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0049
634 Squalene monooxygenase SQLE 0.0049
7196 Squalene monooxygenase ERG1 0.0049
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0048
2981 Phospholipase A2, membrane associated PLA2G2A 0.0048
760 Fibroblast growth factor 1 FGF1 0.0048
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0047
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0047
2159 Quinone oxidoreductase CRYZ 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0046
527 Prostacyclin receptor PTGIR 0.0045
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0045
6212 Tubulin gamma-1 chain TUBG1 0.0045
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0044
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0044
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0044
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
517 Alcohol dehydrogenase 1C ADH1C 0.0043
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0043
6151 Monocarboxylate transporter 10 SLC16A10 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
484 Tyrosine-protein kinase ABL2 ABL2 0.0042
1569 G1/S-specific cyclin-D1 CCND1 0.0041
76 Nitric-oxide synthase, brain NOS1 0.0041
342 P protein [Includes: DNA-directed DNA polymerase P 0.0041
612 P protein [Includes: DNA-directed DNA polymerase P 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
2320 Thymidine kinase, cytosolic TK1 0.004
291 Nitric-oxide synthase, endothelial NOS3 0.004
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.004
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.004
2371 Pantothenate kinase coaA 0.0039
5818 Folate receptor alpha FOLR1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0039
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0039
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
164 Histamine H4 receptor HRH4 0.0038
85 Growth hormone receptor GHR 0.0038
3639 Thymidine phosphorylase deoA 0.0037
3936 Thymidine phosphorylase TYMP 0.0037
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0037
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0037
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
1063 Signal transducer and activator of transcription 5B STAT5B 0.0037
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0037
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0037
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6218 Pannexin-1 PANX1 0.0036
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0036
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0036
4564 YvbK protein yvbK 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0036
4566 Acyl-CoA hydrolase BC_2038 0.0036
4572 Acyl-CoA hydrolase BH0798 0.0036
4576 Aac(6')-Ii protein aac(6')-Ii 0.0036
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0036
2528 Fatty acid metabolism regulator protein fadR 0.0036
6740 Fatty acid metabolism regulator protein fadR 0.0036
4579 Serine acetyltransferase cysE 0.0036
6807 Serine acetyltransferase cysE 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0034
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0034
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0034
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0034
1039 Histone deacetylase 9 HDAC9 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
3937 Fatty-acid amide hydrolase FAAH 0.0034
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0033
4226 Uridine phosphorylase 2 UPP2 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0031
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0031
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0031
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0031
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0031
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
3489 Acetyl-coenzyme A synthetase acs 0.0031
2396 Formyl-coenzyme A transferase frc 0.0031
3457 Formyl-coenzyme A transferase frc 0.0031
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0031
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0031
3729 Citrate synthase gltA 0.0031
4575 Citrate synthase cit 0.0031
4580 Citrate synthase gltA 0.0031
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0031
4563 Acetyl transferase rimL 0.0031
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3560 Gentamicin 3'-acetyltransferase aacC1 0.0031
4225 Uridine phosphorylase 1 UPP1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
646 Malate dehydrogenase, cytoplasmic MDH1 0.0029
4573 Histone acetyltransferase PCAF KAT2B 0.0029
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0029
2560 Galactoside O-acetyltransferase lacA 0.0029
3199 Phosphopantetheine adenylyltransferase coaD 0.0029
3543 Phosphopantetheine adenylyltransferase coaD 0.0029
3567 Phosphopantetheine adenylyltransferase coaD 0.0029
5289 Phosphopantetheine adenylyltransferase coaD 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
2248 Malate synthase G glcB 0.0028
3190 Malate synthase G glcB 0.0028
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
3178 Formate acetyltransferase 1 pflB 0.0028
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0028
666 NADP-dependent malic enzyme ME1 0.0028
413 Amidophosphoribosyltransferase PPAT 0.0028
2515 Amidophosphoribosyltransferase purF 0.0028
3714 Amidophosphoribosyltransferase purF 0.0028
2391 Ferrochelatase hemH 0.0028
6502 Ferrochelatase DKFZp686P18130 0.0028
1591 Ferrochelatase, mitochondrial FECH 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
340 Apoptotic protease-activating factor 1 APAF1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4404 FcbC1 protein fcbC 0.0027
2207 Rhodopsin RHO 0.0027
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
473 L-lactate dehydrogenase A chain LDHA 0.0026
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
2021 Thrombomodulin THBD 0.0025
5322 Oxidoreductase ydhF ydhF 0.0025
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0025
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0025
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0025
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0025
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0025
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0025
5332 MtdA bifunctional protein mtdA 0.0025
3778 NAD(P) transhydrogenase subunit beta pntB 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
4403 Protein iolS iolS 0.0025
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0025
5330 General stress protein 69 yhdN 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
3957 Adenosine deaminase ADA 0.0024
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0024
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0024
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0024
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0024
6493 Cytochrome c oxidase subunit 6C COX6C 0.0024
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0024
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0024
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0024
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0024
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0024
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0024
6559 Cytochrome c oxidase subunit 2 ctaC 0.0024
6669 Cytochrome c oxidase subunit 2 ctaC 0.0024
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0024
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0024
6558 Cytochrome c oxidase subunit 1 ctaD 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1360 Sphingomyelin phosphodiesterase SMPD1 0.0024
6042 Prostaglandin reductase 2 PTGR2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
1313 Lactoylglutathione lyase GLO1 0.0024
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0024
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
2596 Acetyl-CoA acetyltransferase phbA 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1341 Histamine H3 receptor HRH3 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
654 Flavin reductase BLVRB 0.0023
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
2540 Choloylglycine hydrolase cbh 0.0022
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
5073 Ferredoxin--NADP reductase petH 0.0022
5076 Ferredoxin--NADP reductase fpr 0.0022
5119 Ferredoxin--NADP reductase petH 0.0022
5121 Ferredoxin--NADP reductase fpr 0.0022
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0022
5328 Prostaglandin F synthase Tb11.02.2310 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0022
3446 NADP-dependent alcohol dehydrogenase adh 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
2286 Isocitrate dehydrogenase [NADP] icd 0.0022
2302 Isocitrate dehydrogenase [NADP] icd 0.0022
2771 Isocitrate dehydrogenase [NADP] icd 0.0022
4582 Putative pteridine reductase 2 ptr2 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0022
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0022
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
989 L-xylulose reductase DCXR 0.0022
3404 Exotoxin A eta 0.0022
298 Renin REN 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
6501 Fatty acid-binding protein, liver FABP1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
6297 Prostaglandin reductase 1 PTGR1 0.002
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.002
4531 Putative ketoacyl reductase actIII 0.002
3062 Aspartate-semialdehyde dehydrogenase asd 0.002
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1058 Cell division protein kinase 5 CDK5 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
2675 Pteridine reductase 1 PTR1 0.0019
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
1124 Sepiapterin reductase SPR 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
822 Aldose reductase AKR1B1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6500 Phospholipase A2 PLA2G1B 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
3830 Calreticulin CALR 0.0017
5288 Shikimate kinase aroK 0.0017
5287 Signaling protein Not Available 0.0017
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0017
5293 Shikimate kinase 2 aroL 0.0017
5304 UPF0166 protein TM_0021 TM_0021 0.0017
4346 Polynucleotide kinase pseT 0.0017
5292 Putative partitioning protein TT_C1605 0.0017
5276 Chromosomal replication initiator protein dnaA dnaA 0.0017
5266 Activator of hgdC 0.0017
5259 Transcriptional regulator ntrC1 0.0017
6699 Transcriptional regulator Cgl2612 0.0017
2874 Nitrogenase iron protein 1 nifH1 0.0017
5283 D-alanine--D-alanine ligase B ddlB 0.0017
5281 Plasmid segregation protein parM parM 0.0017
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0017
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0017
5299 D-alanine--D-alanine ligase ddl 0.0017
6598 D-alanine--D-alanine ligase ddl 0.0017
5315 Chaperone protein htpG htpG 0.0017
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0017
5261 Phosphoribosylformylglycinamidine synthase purL 0.0017
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0017
5291 Glycogen synthase 1 glgA1 0.0017
5264 DNA replication protein REP 0.0017
5277 Preprotein translocase subunit secA secA 0.0017
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0017
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0017
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0017
5284 Large T antigen Not Available 0.0017
5308 Preprotein translocase secA 1 subunit secA1 0.0017
5285 Kinesin heavy chain KIF5B 0.0017
2091 Endoplasmin HSP90B1 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0016
4041 Microsomal glutathione S-transferase 2 MGST2 0.0016
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
207 Glutathione synthetase GSS 0.0015
5269 Glutathione synthetase gshB 0.0015
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
3221 Cytochrome c4 cc4 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
4837 Cag-alfa cag-alfa 0.0013
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0013
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0013
5646 Galactokinase GALK1 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
5302 TrwB trwB 0.0013
5265 FtsH ftsH 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4774 NTPase P4 Not Available 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1721 Glycogen synthase kinase-3 beta GSK3B 0.0013
4031 Glutathione S-transferase A1 GSTA1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2683 Mono-ADP-ribosyltransferase C3 C3 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
5312 Kinesin-like protein KIF1A KIF1A 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
6859 Protein S100-A4 S100A4 0.0012
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
2282 Protein recA recA 0.0011
2315 Protein recA recA 0.0011
2332 Protein recA recA 0.0011
5263 Protein recA recA 0.0011
408 Riboflavin kinase RFK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2615 Chemotaxis protein cheA cheA 0.0011
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0011
1881 Hexokinase-1 HK1 0.0011
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0011
2892 Acetylglutamate kinase argB 0.0011
3550 Acetylglutamate kinase argB 0.0011
3669 Ribokinase rbsK 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.001
714 Glutathione reductase, mitochondrial GSR 0.001
788 Creatine kinase M-type CKM 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2727 S-adenosylmethionine synthetase metK 0.001
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2697 Uridine-cytidine kinase 2 UCK2 0.001
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
810 Heme oxygenase 1 HMOX1 0.001
3391 Heme oxygenase 1 pbsA1 0.001
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.001
2298 Cytochrome P450-cam camC 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
48 Pyridoxal kinase PDXK 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6395 Myosin-14 MYH14 0.0009
2251 Thymidylate kinase tmk 0.0009
2254 Thymidylate kinase DTYMK 0.0009
3522 Thymidylate kinase tmk 0.0009
816 Biliverdin reductase A BLVRA 0.0009
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0009
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0009
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
2132 Protein S100-B S100B 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0008
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0008
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0008
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0008
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0008
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0008
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0008
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0008
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0008
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0008
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0008
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0008
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0008
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0008
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0008
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0008
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0008
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0008
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0008
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0008
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0008
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0008
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0008
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0008
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0008
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0008
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0008
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0008
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0008
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0008
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0008
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0008
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0008
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0008
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0008
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0008
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0008
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0008
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0008
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0008
107 C-4 methylsterol oxidase SC4MOL 0.0008
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0008
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0008
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0008
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0008
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0008
729 GDP-L-fucose synthetase TSTA3 0.0008
3463 GDP-L-fucose synthetase fcl 0.0008
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0008
167 L-lactate dehydrogenase C chain LDHC 0.0008
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0008
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0008
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0008
3726 D-3-phosphoglycerate dehydrogenase serA 0.0008
4291 D-3-phosphoglycerate dehydrogenase serA 0.0008
206 3-keto-steroid reductase HSD17B7 0.0008
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0008
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0008
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0008
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0008
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0008
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0008
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0008
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0008
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0008
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0008
34 7-dehydrocholesterol reductase DHCR7 0.0008
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0008
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0008
711 UDP-glucose 6-dehydrogenase UGDH 0.0008
3672 UDP-glucose 6-dehydrogenase hasB 0.0008
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0008
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0008
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0008
643 Peroxisomal bifunctional enzyme EHHADH 0.0008
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0008
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0008
3822 Actin, alpha skeletal muscle ACTA1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0008
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0008
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0008
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0008
396 Alcohol dehydrogenase 4 ADH4 0.0008
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0008
328 Sorbitol dehydrogenase SORD 0.0008
597 Dihydropteridine reductase QDPR 0.0008
1867 Major prion protein PRNP 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
1507 Cytochrome c CYCS 0.0008
509 Thymidine kinase TK 0.0008
570 Thymidine kinase TK 0.0008
2559 Thymidine kinase TK 0.0008
3430 Thymidine kinase tdk 0.0008
3518 Thymidine kinase TK 0.0008
5301 Thymidine kinase tdk 0.0008
5771 Thymidine kinase ORF36 0.0008
7009 Thymidine kinase ORF36 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
1025 Aquaporin-1 AQP1 0.0008
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0007
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0007
6026 Alcohol dehydrogenase 6 ADH6 0.0007
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0007
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0007
626 Cysteine dioxygenase type 1 CDO1 0.0007
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0007
627 11-cis retinol dehydrogenase RDH5 0.0007
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
125 DNA polymerase beta POLB 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
279 Tyrosinase TYR 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
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