DT-Web

DB00619 - Imatinib


Identification
Name Imatinib
Accession Number DB00619 (APRD01028, DB03261, EXPT02967)
Type small molecule
Description Imatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 493.6027
Groups approved
Monoisotopic Weight 493.259008649
Pharmacology
Indication For the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST).
Mechanism of action Imatinib mesylate is a protein-tyrosine kinase inhibitor that inhibits the Bcr-Abl tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in chronic myeloid leukemia (CML). It inhibits proliferation and induces apoptosis in Bcr-Abl positive cell lines as well as fresh leukemic cells from Philadelphia chromosome positive chronic myeloid leukemia. Imatinib also inhibits the receptor tyrosine kinases for platelet derived growth factor (PDGF) and stem cell factor (SCF) - called c-kit. Imatinib was identified in the late 1990s by Dr Brian J. Druker. Its development is an excellent example of rational drug design. Soon after identification of the bcr-abl target, the search for an inhibitor began. Chemists used a high-throughput screen of chemical libraries to identify the molecule 2-phenylaminopyrimidine. This lead compound was then tested and modified by the introduction of methyl and benzamide groups to give it enhanced binding properties, resulting in imatinib.
Absorption The pharmacokinetics in CML and GIST patients are similar. Imatinib is well absorbed with mean absolute bioavailability is 98% and maximum plasma levels achieved within 2-4 hours of dosing
Protein binding 95% protein bound, mostly to albumin and alpha-1-acid glycoprotein.
Biotransformation Primarily hepatic via CYP3A4. Other cytochrome P450 enzymes, such as CYP1A2, CYP2D6, CYP2C9, and CYP2C19, play a minor role in its metabolism. The main circulating active metabolite in humans is the N-demethylated piperazine derivative, formed predominantly by CYP3A4. This metabolite is similar in potency to the parent compound.
Route of elimination Imatinib elimination is predominately in the feces, mostly as metabolites. 81% of the dose is eliminated within 7 days, in feces (68% of the dose) and urine (13% of the dose). Unchanged imatinib accounted for 25% of the dose (5% urine, 20% faces), the remainder being metabolites.
Toxicity The most frequently reported adverse reactions (>30%) were edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue and abdominal pain.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Imatinib may increase the anticoagulant effect of acenocoumarol.
Acetaminophen Increased hepatic toxicity of both agents
Anisindione Imatinib may increase the anticoagulant effect of anisindione.
Aprepitant Aprepitant may change levels of the chemotherapy agent, imatinib.
Atorvastatin Imatinib, a strong CYP3A4 inhibitor, may increase the effect and toxicity of atorvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if imatinib is initiated, discontinued or dose changed.
Bromazepam Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if imatinib is initiated, discontinued or dose changed. Dosage adjustments may be required.
Carbamazepine Carbamazepine, a strong CYP3A4 inducer, may increase the metabolism of imatinib. Imatinib, a strong CYP3A4 inhibitor, may increase the metabolism of carbamazepine. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed.
Cerivastatin Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of cerivastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cerivastatin if imatinib is initiated, discontinued or dose changed.
Clarithromycin The macrolide, clarithromycin, may increase the serum concentration of imatinib.
Cyclosporine Imatinib increases the effect and toxicity of cyclosporine
Dantrolene Imatinib may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if imatinib is initiated, discontinued or dose changed.
Dexamethasone Dexamethasone may decrease levels of imatinib.
Dicumarol Imatinib may increase the anticoagulant effect of dicumarol.
Erythromycin The macrolide, erythromycin, may increase the serum concentration of imatinib.
Ethotoin The hydantoin decreases the levels of imatinib
Etravirine Imatinib, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid this combination if alternative are available. If concurrent use is not avoidable, it is recommended to increase the dosage of cabozantinib by a minimum of 50%, and to monitor therapy.
Fosphenytoin The hydantoin decreases the levels of imatinib
Itraconazole Itraconazole may increase the levels of imatinib.
Josamycin The macrolide, josamycin, may increase the serum concentration of imatinib.
Ketoconazole Ketoconazole may increase the levels of imatinib.
Lovastatin Imatinib, a strong CYP3A4 inhibitor, may increase the effect and toxicity of lovastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lovastatin if imatinib is initiated, discontinued or dose changed.
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Mephenytoin The hydantoin decreases the levels of imatinib
Nifedipine Imatinib increases the effect and toxicity of nifedipine
Phenobarbital Phenobarbital decreases levels of imatinib
Phenytoin The hydantoin decreases the levels of imatinib
Pimozide Imatinib may increase the effect and toxicity of pimozide.
Rifampin Rifampin decreases levels of imatinib
Simvastatin Imatinib, a strong CYP3A4 inhibitor, may increase the effect and toxicity of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if imatinib is initiated, discontinued or dose changed.
St. John's Wort St. John's Wort decreases levels of imatinib
Tacrolimus The strong CYP3A4 inhibitor, Imatinib, may decrease the metabolism and clearance of Tacrolimus, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Tacrolimus if Imatinib is initiated, discontinued or dose changed.
Tadalafil Imatinib may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Imatinib may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Imatinib may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Imatinib is initiated, discontinued or dose changed.
Tamsulosin Imatinib, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Imatinib is initiated, discontinued, or dose changed.
Telithromycin Co-administration may result in altered plasma concentrations of Imatinib and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents.
Temsirolimus Imatinib may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Imatinib, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Imatinib is initiated, discontinued or dose changed.
Tiagabine The strong CYP3A4 inhibitor, Imatinib, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Imatinib is initiated, discontinued or dose changed.
Tolterodine Imatinib may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan The BCRP/ABCG2 inhibitor, Imatinib, may increase the bioavailability and serum concentration of oral Topotecan. Monitor for change in the therapeutic and adverse effects of Topotecan if Imatinib is initiated, discontinued or dose changed.
Tramadol Imatinib may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Imatinib may decrease the effect of Tramadol by decreasing active metabolite production.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trazodone The CYP3A4 inhibitor, Imatinib, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Imatinib is initiated, discontinued or dose changed.
Trimipramine The strong CYP3A4 inhibitor, Imatinib, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Imatinib is initiated, discontinued or dose changed.
Vardenafil Imatinib, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Venlafaxine Imatinib, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Imatinib is initiated, discontinued, or dose changed.
Verapamil Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Imatinib is initiated, discontinued or dose changed.
Vinblastine Imatinib, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Imatinib is initiated, discontinued or dose changed.
Vincristine Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Imatinib is initiated, discontinued or dose changed.
Vinorelbine Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Imatinib is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of imatinib by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of imatinib if voriconazole is initiated, discontinued or dose changed.
Warfarin Imatinib may increase the anticoagulant effect of warfarin increasing the risk of bleeding. Monitor for changes in prothrombin time and therapeutic and adverse effects of warfarin if imatinib is initiated, discontinued or dose changed.
Zonisamide Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if imatinib is initiated, discontinued or dose changed.
Zopiclone Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if imatinib is initiated, discontinued or dose changed.
Food Interactions
  • Take with food to reduce the incidence of gastric irritation. Follow with a large glass of water. A lipid rich meal will slightly reduce and delay absorption. Avoid grapefruit and grapefruit juice throughout treatment, grapefruit can significantly increase serum levels of this product.

Targets


BCR/ABL fusion protein isoform X9
Name BCR/ABL fusion protein isoform X9
Gene Name BCR/ABL fusion
Pharmacological action yes
Actions inhibitor
References
  • Nadal E, Olavarria E: Imatinib mesylate (Gleevec/Glivec) a molecular-targeted therapy for chronic myeloid leukaemia and other malignancies. Int J Clin Pract. 2004 May;58(5):511-6. - Pubmed
  • Waller CF: Imatinib mesylate. Recent Results Cancer Res. 2010;184:3-20. - Pubmed
  • Croom KF, Perry CM: Imatinib mesylate: in the treatment of gastrointestinal stromal tumours. Drugs. 2003;63(5):513-22; discussion 523-4. - Pubmed
DTHybrid score 0.3885
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action yes
Actions antagonist,multitarget
References
  • Lee JL, Kim JY, Ryu MH, Kang HJ, Chang HM, Kim TW, Lee H, Park JH, Kim HC, Kim JS, Kang YK: Response to imatinib in KIT- and PDGFRA-wild type gastrointestinal stromal associated with neurofibromatosis type 1. Dig Dis Sci. 2006 Jun;51(6):1043-6. - Pubmed
  • Dy GK, Miller AA, Mandrekar SJ, Aubry MC, Langdon RM Jr, Morton RF, Schild SE, Jett JR, Adjei AA: A phase II trial of imatinib (ST1571) in patients with c-kit expressing relapsed small-cell lung cancer: a CALGB and NCCTG study. Ann Oncol. 2005 Nov;16(11):1811-6. Epub 2005 Aug 8. - Pubmed
  • Rutkowski P, Nowecki ZI, Debiec-Rychter M, Grzesiakowska U, Michej W, Wozniak A, Siedlecki JA, Limon J, Dobosz AJ, Kakol M, Osuch C, Ruka W: Predictive factors for long-term effects of imatinib therapy in patients with inoperable/metastatic CD117(+) gastrointestinal stromal tumors (GISTs). J Cancer Res Clin Oncol. 2007 Sep;133(9):589-97. Epub 2007 Apr 26. - Pubmed
  • De Giorgi U: KIT mutations and imatinib dose effects in patients with gastrointestinal stromal tumors. J Clin Oncol. 2007 Mar 20;25(9):1146-7; author reply 1147-8. - Pubmed
  • Posadas EM, Kwitkowski V, Kotz HL, Espina V, Minasian L, Tchabo N, Premkumar A, Hussain MM, Chang R, Steinberg SM, Kohn EC: A prospective analysis of imatinib-induced c-KIT modulation in ovarian cancer: a phase II clinical study with proteomic profiling. Cancer. 2007 Jul 15;110(2):309-17. - Pubmed
DTHybrid score 0.4984
RET proto-oncogene
Name RET proto-oncogene
Gene Name RET
Pharmacological action yes
Actions inhibitor
References
  • de Groot JW, Plaza Menacho I, Schepers H, Drenth-Diephuis LJ, Osinga J, Plukker JT, Links TP, Eggen BJ, Hofstra RM: Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations. Surgery. 2006 Jun;139(6):806-14. - Pubmed
DTHybrid score 0.388
High affinity nerve growth factor receptor
Name High affinity nerve growth factor receptor
Gene Name NTRK1
Pharmacological action unknown
Actions antagonist
References
  • Catani M, De Milito R, Simi M: [New orientations in the management of advanced, metastatic gastrointestinal stromal tumors (GIST): combination of surgery and systemic therapy with imatinib in a case of primary gastric location] Chir Ital. 2005 Jan-Feb;57(1):127-33. - Pubmed
  • Kovacs M, Nagy P, Pak G, Feher J: [Gastrointestinal stromal tumors (GISTs): clinical and pathological features] Orv Hetil. 2005 Jun 26;146(26):1375-81. - Pubmed
  • de Groot JW, Plaza Menacho I, Schepers H, Drenth-Diephuis LJ, Osinga J, Plukker JT, Links TP, Eggen BJ, Hofstra RM: Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations. Surgery. 2006 Jun;139(6):806-14. - Pubmed
  • de Groot JW, Zonnenberg BA, van Ufford-Mannesse PQ, de Vries MM, Links TP, Lips CJ, Voest EE: A Phase II Trial of Imatinib Therapy for Metastatic Medullary Thyroid Carcinoma. J Clin Endocrinol Metab. 2007 Sep;92(9):3466-9. Epub 2007 Jun 19. - Pubmed
  • Delbaldo C: [Pharmacokinetic-pharmacodynamics relationships of imatinib (Glivec)] Therapie. 2007 Mar-Apr;62(2):87-90. Epub 2007 Jun 21. - Pubmed
DTHybrid score 0.3265
Macrophage colony-stimulating factor 1 receptor
Name Macrophage colony-stimulating factor 1 receptor
Gene Name CSF1R
Pharmacological action unknown
Actions antagonist
References
  • Dewar AL, Zannettino AC, Hughes TP, Lyons AB: Inhibition of c-fms by imatinib: expanding the spectrum of treatment. Cell Cycle. 2005 Jul;4(7):851-3. Epub 2005 Jul 28. - Pubmed
  • Taylor JR, Brownlow N, Domin J, Dibb NJ: FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene. 2006 Jan 5;25(1):147-51. - Pubmed
  • Dewar AL, Farrugia AN, Condina MR, Bik To L, Hughes TP, Vernon-Roberts B, Zannettino AC: Imatinib as a potential antiresorptive therapy for bone disease. Blood. 2006 Jun 1;107(11):4334-7. Epub 2006 Jan 31. - Pubmed
  • Ando W, Hashimoto J, Nampei A, Tsuboi H, Tateishi K, Ono T, Nakamura N, Ochi T, Yoshikawa H: Imatinib mesylate inhibits osteoclastogenesis and joint destruction in rats with collagen-induced arthritis (CIA). J Bone Miner Metab. 2006;24(4):274-82. - Pubmed
  • El Hajj Dib I, Gallet M, Mentaverri R, Sevenet N, Brazier M, Kamel S: Imatinib mesylate (Gleevec) enhances mature osteoclast apoptosis and suppresses osteoclast bone resorbing activity. Eur J Pharmacol. 2006 Dec 3;551(1-3):27-33. Epub 2006 Sep 16. - Pubmed
DTHybrid score 1.1105
Alpha platelet-derived growth factor receptor
Name Alpha platelet-derived growth factor receptor
Gene Name PDGFRA
Pharmacological action unknown
Actions antagonist
References
  • Yi ES, Strong CR, Piao Z, Perucho M, Weidner N: Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity. Appl Immunohistochem Mol Morphol. 2005 Jun;13(2):157-61. - Pubmed
  • Borbenyi Z: [Disorders with eosinophilia, treatment of hypereosinophilic syndrome] Orv Hetil. 2005 May 1;146(18 Suppl 1):911-6. - Pubmed
  • Corless CL, Schroeder A, Griffith D, Town A, McGreevey L, Harrell P, Shiraga S, Bainbridge T, Morich J, Heinrich MC: PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol. 2005 Aug 10;23(23):5357-64. Epub 2005 May 31. - Pubmed
  • Chen LL, Sabripour M, Andtbacka RH, Patel SR, Feig BW, Macapinlac HA, Choi H, Wu EF, Frazier ML, Benjamin RS: Imatinib resistance in gastrointestinal stromal tumors. Curr Oncol Rep. 2005 Jul;7(4):293-9. - Pubmed
  • Tefferi A: Modern diagnosis and treatment of primary eosinophilia. Acta Haematol. 2005;114(1):52-60. - Pubmed
DTHybrid score 0.5861
Epithelial discoidin domain-containing receptor 1
Name Epithelial discoidin domain-containing receptor 1
Gene Name DDR1
Pharmacological action unknown
Actions antagonist
References
  • Gotlib J, Berube C, Growney JD, Chen CC, George TI, Williams C, Kajiguchi T, Ruan J, Lilleberg SL, Durocher JA, Lichy JH, Wang Y, Cohen PS, Arber DA, Heinrich MC, Neckers L, Galli SJ, Gilliland DG, Coutre SE: Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood. 2005 Oct 15;106(8):2865-70. Epub 2005 Jun 21. - Pubmed
  • Xu L, Tong R, Cochran DM, Jain RK: Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 2005 Jul 1;65(13):5711-9. - Pubmed
  • Neef M, Ledermann M, Saegesser H, Schneider V, Widmer N, Decosterd LA, Rochat B, Reichen J: Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term. J Hepatol. 2006 Jan;44(1):167-75. Epub 2005 Jul 12. - Pubmed
  • Jubert C, Geoerger B, Grill J, Hartmann O, Vassal G: [Targeted therapies in pediatric oncology: a new therapeutic approach?] Arch Pediatr. 2006 Feb;13(2):189-94. Epub 2005 Nov 17. - Pubmed
  • Benjamin RS, Blanke CD, Blay JY, Bonvalot S, Eisenberg B: Management of gastrointestinal stromal tumors in the imatinib era: selected case studies. Oncologist. 2006 Jan;11(1):9-20. - Pubmed
DTHybrid score 0.3874
Proto-oncogene tyrosine-protein kinase ABL1
Name Proto-oncogene tyrosine-protein kinase ABL1
Gene Name ABL1
Pharmacological action unknown
Actions inhibitor
References
  • Hoerth E, Kodym R: Involvment of c-Abl in the radiation-induced inhibition of myoblast differentiation. Int J Radiat Biol. 2004 Oct;80(10):729-36. - Pubmed
  • Dewar AL, Zannettino AC, Hughes TP, Lyons AB: Inhibition of c-fms by imatinib: expanding the spectrum of treatment. Cell Cycle. 2005 Jul;4(7):851-3. Epub 2005 Jul 28. - Pubmed
  • Agirre X, Roman-Gomez J, Vazquez I, Jimenez-Velasco A, Larrayoz MJ, Lahortiga I, Andreu EJ, Marquez J, Beltran de Heredia JM, Odero MD, Prosper F, Calasanz MJ: Coexistence of different clonal populations harboring the b3a2 (p210) and e1a2 (p190) BCR-ABL1 fusion transcripts in chronic myelogenous leukemia resistant to imatinib. Cancer Genet Cytogenet. 2005 Jul 1;160(1):22-6. - Pubmed
  • Brueggemeier SB, Wu D, Kron SJ, Palecek SP: Protein-acrylamide copolymer hydrogels for array-based detection of tyrosine kinase activity from cell lysates. Biomacromolecules. 2005 Sep-Oct;6(5):2765-75. - Pubmed
  • Haberler C, Gelpi E, Marosi C, Rossler K, Birner P, Budka H, Hainfellner JA: Immunohistochemical analysis of platelet-derived growth factor receptor-alpha, -beta, c-kit, c-abl, and arg proteins in glioblastoma: possible implications for patient selection for imatinib mesylate therapy. J Neurooncol. 2006 Jan;76(2):105-9. - Pubmed
DTHybrid score 1.023
Beta platelet-derived growth factor receptor
Name Beta platelet-derived growth factor receptor
Gene Name PDGFRB
Pharmacological action unknown
Actions antagonist
References
  • Basciani S, Brama M, Mariani S, De Luca G, Arizzi M, Vesci L, Pisano C, Dolci S, Spera G, Gnessi L: Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity. Cancer Res. 2005 Mar 1;65(5):1897-903. - Pubmed
  • Jones RL, Judson IR: The development and application of imatinib. Expert Opin Drug Saf. 2005 Mar;4(2):183-91. - Pubmed
  • Modi S, Seidman AD, Dickler M, Moasser M, D'Andrea G, Moynahan ME, Menell J, Panageas KS, Tan LK, Norton L, Hudis CA: A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer. Breast Cancer Res Treat. 2005 Mar;90(2):157-63. - Pubmed
  • Johnson FM, Saigal B, Donato NJ: Induction of heparin-binding EGF-like growth factor and activation of EGF receptor in imatinib mesylate-treated squamous carcinoma cells. J Cell Physiol. 2005 Nov;205(2):218-27. - Pubmed
  • Chen J, Rocken C, Nitsche B, Hosius C, Gschaidmeier H, Kahl S, Malfertheiner P, Ebert MP: The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression. Cancer Lett. 2006 Feb 28;233(2):328-37. - Pubmed
DTHybrid score 0.5677

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Novartis Pharma AG. Gleevec® (imatinib mesylate) tablets prescribing information. East Hanover, NJ; 2006 Sep. -
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.1348
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6866
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
DTHybrid score 0.5366
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Novartis Pharma AG. Gleevec® (imatinib mesylate) tablets prescribing information. East Hanover, NJ; 2006 Sep. -
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.706
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Novartis Pharma AG. Gleevec® (imatinib mesylate) tablets prescribing information. East Hanover, NJ; 2006 Sep. -
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.7875
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Novartis Pharma AG. Gleevec® (imatinib mesylate) tablets prescribing information. East Hanover, NJ; 2006 Sep. -
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.807
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Novartis Pharma AG. Gleevec® (imatinib mesylate) tablets prescribing information. East Hanover, NJ; 2006 Sep. -
DTHybrid score 0.7
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.6083

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate,inhibitor
References
  • Davies A, Jordanides NE, Giannoudis A, Lucas CM, Hatziieremia S, Harris RJ, Jorgensen HG, Holyoake TL, Pirmohamed M, Clark RE, Mountford JC: Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia. 2009 Nov;23(11):1999-2006. Epub 2009 Aug 27. - Pubmed
  • Engler JR, Frede A, Saunders VA, Zannettino AC, Hughes TP, White DL: Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. Leukemia. 2010 Apr;24(4):765-70. Epub 2010 Feb 11. - Pubmed
  • Ahlin G, Karlsson J, Pedersen JM, Gustavsson L, Larsson R, Matsson P, Norinder U, Bergstrom CA, Artursson P: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008 Oct 9;51(19):5932-42. Epub 2008 Sep 13. - Pubmed
DTHybrid score 0.4484
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Davies A, Jordanides NE, Giannoudis A, Lucas CM, Hatziieremia S, Harris RJ, Jorgensen HG, Holyoake TL, Pirmohamed M, Clark RE, Mountford JC: Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia. 2009 Nov;23(11):1999-2006. Epub 2009 Aug 27. - Pubmed
  • Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. Epub 2010 Apr 27. - Pubmed
  • Hamada A, Miyano H, Watanabe H, Saito H: Interaction of imatinib mesilate with human P-glycoprotein. J Pharmacol Exp Ther. 2003 Nov;307(2):824-8. Epub 2003 Sep 15. - Pubmed
  • Thomas J, Wang L, Clark RE, Pirmohamed M: Active transport of imatinib into and out of cells: implications for drug resistance. Blood. 2004 Dec 1;104(12):3739-45. Epub 2004 Aug 17. - Pubmed
  • Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. Epub 2009 Sep 28. - Pubmed
  • Giannoudis A, Davies A, Lucas CM, Harris RJ, Pirmohamed M, Clark RE: Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia. Blood. 2008 Oct 15;112(8):3348-54. Epub 2008 Jul 31. - Pubmed
  • Breedveld P, Pluim D, Cipriani G, Wielinga P, van Tellingen O, Schinkel AH, Schellens JH: The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. Cancer Res. 2005 Apr 1;65(7):2577-82. - Pubmed
  • Oka M, Fukuda M, Soda H: [Anticancer drugs and ABC transporters] Gan To Kagaku Ryoho. 2005 May;32(5):585-92. - Pubmed
  • Burger H, van Tol H, Brok M, Wiemer EA, de Bruijn EA, Guetens G, de Boeck G, Sparreboom A, Verweij J, Nooter K: Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52. Epub 2005 Jul 9. - Pubmed
  • Galimberti S, Cervetti G, Guerrini F, Testi R, Pacini S, Fazzi R, Simi P, Petrini M: Quantitative molecular monitoring of BCR-ABL and MDR1 transcripts in patients with chronic myeloid leukemia during Imatinib treatment. Cancer Genet Cytogenet. 2005 Oct 1;162(1):57-62. - Pubmed
  • Gardner ER, Burger H, van Schaik RH, van Oosterom AT, de Bruijn EA, Guetens G, Prenen H, de Jong FA, Baker SD, Bates SE, Figg WD, Verweij J, Sparreboom A, Nooter K: Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib. Clin Pharmacol Ther. 2006 Aug;80(2):192-201. - Pubmed
DTHybrid score 0.8368
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Tanihara Y, Masuda S, Katsura T, Inui K: Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2. Biochem Pharmacol. 2009 Nov 1;78(9):1263-71. Epub 2009 Jun 18. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3827
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P: Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res. 2004 Apr 1;64(7):2333-7. - Pubmed
  • An Y, Ongkeko WM: ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1529-42. - Pubmed
  • Davies A, Jordanides NE, Giannoudis A, Lucas CM, Hatziieremia S, Harris RJ, Jorgensen HG, Holyoake TL, Pirmohamed M, Clark RE, Mountford JC: Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia. 2009 Nov;23(11):1999-2006. Epub 2009 Aug 27. - Pubmed
  • Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. Epub 2010 Apr 27. - Pubmed
  • Burger H, van Tol H, Boersma AW, Brok M, Wiemer EA, Stoter G, Nooter K: Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2. Epub 2004 Jul 13. - Pubmed
  • Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. Epub 2009 Sep 28. - Pubmed
  • Breedveld P, Pluim D, Cipriani G, Wielinga P, van Tellingen O, Schinkel AH, Schellens JH: The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. Cancer Res. 2005 Apr 1;65(7):2577-82. - Pubmed
  • Oka M, Fukuda M, Soda H: [Anticancer drugs and ABC transporters] Gan To Kagaku Ryoho. 2005 May;32(5):585-92. - Pubmed
  • Burger H, van Tol H, Brok M, Wiemer EA, de Bruijn EA, Guetens G, de Boeck G, Sparreboom A, Verweij J, Nooter K: Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52. Epub 2005 Jul 9. - Pubmed
  • Yanase K, Tsukahara S, Mitsuhashi J, Sugimoto Y: Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development. Cancer Lett. 2006 Mar 8;234(1):73-80. Epub 2005 Nov 21. - Pubmed
  • Nakanishi T, Shiozawa K, Hassel BA, Ross DD: Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. Blood. 2006 Jul 15;108(2):678-84. Epub 2006 Mar 16. - Pubmed
DTHybrid score 0.5419
ATP-binding cassette sub-family A member 3
Name ATP-binding cassette sub-family A member 3
Gene Name ABCA3
Actions substrate
References
  • Chapuy B, Panse M, Radunski U, Koch R, Wenzel D, Inagaki N, Haase D, Truemper L, Wulf GG: ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug. Haematologica. 2009 Nov;94(11):1528-36. - Pubmed
DTHybrid score 0.3871

Carriers


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.4484
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.8368
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions
References Not Available
DTHybrid score 0.3827
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.5419
ATP-binding cassette sub-family A member 3
Name ATP-binding cassette sub-family A member 3
Gene Name ABCA3
Actions
References Not Available
DTHybrid score 0.3871

Predictions


Id Partner name Gene Name Score
4924 Cytochrome P450 2C8 CYP2C8 0.4591
6030 Cytochrome P450 2B6 CYP2B6 0.2999
6013 Cytochrome P450 2E1 CYP2E1 0.2217
6024 Cytochrome P450 1A1 CYP1A1 0.2132
290 Prostaglandin G/H synthase 2 PTGS2 0.2108
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1857
26 Vascular endothelial growth factor receptor 3 FLT4 0.1848
1128 Alpha-2-macroglobulin A2M 0.1817
32 Vascular endothelial growth factor receptor 1 FLT1 0.1785
407 Vascular endothelial growth factor receptor 2 KDR 0.1701
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1522
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1504
5718 Cytochrome P450 2A6 CYP2A6 0.1423
1729 Solute carrier family 22 member 6 SLC22A6 0.1371
862 Multidrug resistance-associated protein 1 ABCC1 0.132
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1211
165 FL cytokine receptor FLT3 0.1211
492 Histamine H1 receptor HRH1 0.1196
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.1192
556 Alpha-1A adrenergic receptor ADRA1A 0.1117
824 Sodium-dependent serotonin transporter SLC6A4 0.1106
2164 Multidrug resistance-associated protein 4 ABCC4 0.1104
118 Organic cation/carnitine transporter 2 SLC22A5 0.1027
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1007
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.1
6147 Solute carrier family 22 member 3 SLC22A3 0.0992
502 5-hydroxytryptamine 2A receptor HTR2A 0.0985
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0984
6106 Cytochrome P450 2C18 CYP2C18 0.0968
1898 Cytochrome P450 1B1 CYP1B1 0.0944
6142 Solute carrier family 22 member 8 SLC22A8 0.0943
831 D(2) dopamine receptor DRD2 0.0936
5787 Angiopoietin-1 receptor TEK 0.0933
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0914
776 Bile salt export pump ABCB11 0.0914
320 5-hydroxytryptamine 1A receptor HTR1A 0.0906
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0867
936 Ephrin type-A receptor 2 EPHA2 0.0852
3856 Fibroblast growth factor receptor 3 FGFR3 0.0832
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.083
823 Fibroblast growth factor receptor 2 FGFR2 0.0829
766 Beta-2 adrenergic receptor ADRB2 0.0826
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0798
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0785
2599 Tyrosine-protein kinase HCK HCK 0.0779
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0752
193 Beta-1 adrenergic receptor ADRB1 0.0746
318 Alpha-2A adrenergic receptor ADRA2A 0.0733
833 Organic cation/carnitine transporter 1 SLC22A4 0.0719
632 Alpha-1B adrenergic receptor ADRA1B 0.0704
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0697
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0695
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0688
5798 Mitogen-activated protein kinase 11 MAPK11 0.0686
6143 Solute carrier family 22 member 7 SLC22A7 0.0672
23 D(1A) dopamine receptor DRD1 0.0654
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0632
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0632
847 Mu-type opioid receptor OPRM1 0.063
789 Alpha-1D adrenergic receptor ADRA1D 0.0623
3811 Cytochrome P450 19A1 CYP19A1 0.0609
713 Sodium-dependent dopamine transporter SLC6A3 0.0592
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0589
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0562
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0547
341 5-hydroxytryptamine 3 receptor HTR3A 0.0535
696 Kappa-type opioid receptor OPRK1 0.053
467 Delta-type opioid receptor OPRD1 0.0528
1024 Solute carrier family 22 member 11 SLC22A11 0.0527
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0524
731 HIV-1 protease HIV-1 protease 0.0522
6824 Tyrosine-protein kinase Lyn LYN 0.0519
3923 Cholinesterase BCHE 0.0511
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.051
450 Muscarinic acetylcholine receptor M4 CHRM4 0.051
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0502
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0495
817 DNA topoisomerase 2-alpha TOP2A 0.0495
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0494
590 5-hydroxytryptamine 2C receptor HTR2C 0.0491
136 Estrogen receptor ESR1 0.0486
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0477
844 Epidermal growth factor receptor EGFR 0.0477
3941 Amine oxidase [flavin-containing] A MAOA 0.0466
871 Glucocorticoid receptor NR3C1 0.0451
6148 Multidrug resistance-associated protein 7 ABCC10 0.0437
6031 Cytochrome P450 3A43 CYP3A43 0.0432
629 Alpha-2B adrenergic receptor ADRA2B 0.0428
465 Calmodulin CALM1 0.0427
378 Alpha-2C adrenergic receptor ADRA2C 0.0424
885 5-hydroxytryptamine 1B receptor HTR1B 0.0422
638 D(3) dopamine receptor DRD3 0.0401
3939 Amine oxidase [flavin-containing] B MAOB 0.04
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0399
2216 Fibroblast growth factor receptor 4 FGFR4 0.0389
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0386
891 Dihydropteroate synthase folP 0.0383
5359 Dihydropteroate synthase folP 0.0383
7175 Dihydropteroate synthase sulI 0.0383
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0375
1063 Signal transducer and activator of transcription 5B STAT5B 0.0375
260 Cytochrome P450 51 ERG11 0.0372
761 Cytochrome P450 51 ERG11 0.0372
3163 Cytochrome P450 51 cyp51 0.0372
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0359
484 Tyrosine-protein kinase ABL2 ABL2 0.0358
6137 Multidrug resistance-associated protein 6 ABCC6 0.0352
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0351
124 Histamine H2 receptor HRH2 0.0349
275 Arachidonate 5-lipoxygenase ALOX5 0.0349
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0348
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0348
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0346
760 Fibroblast growth factor 1 FGF1 0.0341
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0341
1757 Myeloperoxidase MPO 0.0337
725 5-hydroxytryptamine 1D receptor HTR1D 0.0332
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0329
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0329
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0329
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0329
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0326
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0326
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0325
36 Insulin receptor INSR 0.0325
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0322
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0321
756 Sex hormone-binding globulin SHBG 0.0318
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0309
6182 Cytochrome P450 2J2 CYP2J2 0.0307
468 Cytochrome P450 4A11 CYP4A11 0.0305
6141 Sodium/bile acid cotransporter SLC10A1 0.0303
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0303
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0294
477 DNA topoisomerase 4 subunit A parC 0.0293
886 DNA topoisomerase 4 subunit A parC 0.0293
6226 DNA topoisomerase 4 subunit A parC 0.0293
474 Acetylcholinesterase ACHE 0.0288
404 DNA gyrase subunit A gyrA 0.0288
6224 DNA gyrase subunit A gyrA 0.0288
70 Type-1 angiotensin II receptor AGTR1 0.0285
432 D(4) dopamine receptor DRD4 0.0285
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0284
738 Monocarboxylate transporter 1 SLC16A1 0.0281
614 Progesterone receptor PGR 0.0279
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0279
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0278
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0274
4773 Deoxycytidine kinase DCK 0.0271
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0264
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0264
380 Cytochrome P450 17A1 CYP17A1 0.026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0258
6136 Multidrug resistance-associated protein 5 ABCC5 0.0253
146 Androgen receptor AR 0.0253
4604 Liver carboxylesterase 1 CES1 0.0253
122 P2Y purinoceptor 12 P2RY12 0.0249
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0247
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0245
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0241
373 Transthyretin TTR 0.024
436 5-hydroxytryptamine 2B receptor HTR2B 0.0239
811 Translocator protein TSPO 0.0233
1517 Beta-3 adrenergic receptor ADRB3 0.0232
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0232
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0231
869 Estrogen receptor beta ESR2 0.0227
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0226
1353 DNA topoisomerase 1 TOP1 0.0224
3552 DNA topoisomerase 1 topA 0.0224
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0223
4120 NADPH--cytochrome P450 reductase POR 0.022
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0219
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0219
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0217
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0216
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0213
737 Mineralocorticoid receptor NR3C2 0.0212
6220 Aryl hydrocarbon receptor AHR 0.0209
6085 Fatty acid-binding protein, intestinal FABP2 0.0209
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0208
163 D(1B) dopamine receptor DRD5 0.0208
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0207
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0204
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0204
183 Vascular endothelial growth factor A VEGFA 0.0204
7 Nitric oxide synthase, inducible NOS2 0.02
3947 Xanthine dehydrogenase/oxidase XDH 0.0199
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0199
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0199
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0197
777 Tumor necrosis factor TNF 0.0194
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0193
1656 CYP2B protein CYP2B 0.0191
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.019
716 5-hydroxytryptamine 7 receptor HTR7 0.0188
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0187
768 FK506-binding protein 1A FKBP1A 0.0185
161 Tubulin beta chain TUBB 0.0184
312 Tubulin beta chain TUB2 0.0184
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0184
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0184
6014 Cytochrome P450 2A13 CYP2A13 0.0184
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0181
6102 Arylamine N-acetyltransferase 2 NAT2 0.0179
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0178
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0178
33 Cystine/glutamate transporter SLC7A11 0.0177
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0177
29 Tubulin beta-1 chain TUBB1 0.0172
1389 Transforming growth factor beta-1 TGFB1 0.0169
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0169
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0168
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0168
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0168
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0168
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0167
232 Corticosteroid-binding globulin SERPINA6 0.0166
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0166
818 50S ribosomal protein L10 rplJ 0.0165
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0165
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0163
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0161
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.016
131 Synaptic vesicular amine transporter SLC18A2 0.016
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.016
4203 Histamine N-methyltransferase HNMT 0.016
6010 Thiamine transporter 1 SLC19A2 0.0159
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0159
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0159
427 Substance-P receptor TACR1 0.0158
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0157
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0154
1050 Bile salt sulfotransferase SULT2A1 0.0153
6432 Transporter snf 0.0153
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0153
904 Glutathione S-transferase P GSTP1 0.0152
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0151
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0151
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0146
705 Glutamate receptor 1 GRIA1 0.0146
723 Cytosolic phospholipase A2 PLA2G4A 0.0146
94 5-hydroxytryptamine 4 receptor HTR4 0.0146
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0145
273 Apoptosis regulator Bcl-2 BCL2 0.0144
6146 High affinity copper uptake protein 1 SLC31A1 0.0144
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0144
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0142
2539 Tubulin alpha-1 chain TUBA4A 0.0142
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0142
1256 5-hydroxytryptamine 6 receptor HTR6 0.0139
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0139
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0137
528 5-hydroxytryptamine 1E receptor HTR1E 0.0137
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0135
908 Glutathione S-transferase theta-1 GSTT1 0.0134
117 Sterol O-acyltransferase 1 SOAT1 0.0134
1010 Cytochrome P450 51A1 CYP51A1 0.0133
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0132
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0131
952 Dipeptidyl peptidase 4 DPP4 0.0128
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0128
1192 Sulfotransferase 1A1 SULT1A1 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
1178 Adenosine A2a receptor ADORA2A 0.0124
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0123
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0122
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
482 Glycine receptor subunit alpha-1 GLRA1 0.0122
992 Protein tyrosine kinase 2 beta PTK2B 0.0121
3810 Catechol O-methyltransferase COMT 0.0121
16 Adenosine A1 receptor ADORA1 0.012
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0118
603 DNA polymerase alpha catalytic subunit POLA1 0.0118
68 Cannabinoid receptor 1 CNR1 0.0117
511 5-hydroxytryptamine 1F receptor HTR1F 0.0116
1507 Cytochrome c CYCS 0.0115
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0115
1629 Transcription factor AP-1 JUN 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0114
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0113
6070 Nischarin NISCH 0.0113
1852 Microtubule-associated protein 2 MAP2 0.0112
6149 Solute carrier family 22 member 10 SLC22A10 0.0112
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0111
6020 Aldehyde oxidase AOX1 0.011
6043 Putative G-protein coupled receptor 44 GPR44 0.011
976 Platelet glycoprotein IX GP9 0.011
509 Thymidine kinase TK 0.0109
570 Thymidine kinase TK 0.0109
2559 Thymidine kinase TK 0.0109
3430 Thymidine kinase tdk 0.0109
3518 Thymidine kinase TK 0.0109
5301 Thymidine kinase tdk 0.0109
5771 Thymidine kinase ORF36 0.0109
7009 Thymidine kinase ORF36 0.0109
558 Solute carrier family 12 member 1 SLC12A1 0.0107
185 Vasopressin V1a receptor AVPR1A 0.0106
4237 50S ribosomal protein L22 rplV 0.0106
2853 14 kDa fatty acid-binding protein Not Available 0.0105
2211 Fatty acid-binding protein, heart FABP3 0.0105
365 Dihydrofolate reductase DHFR 0.0104
2381 Dihydrofolate reductase DFR1 0.0104
2833 Dihydrofolate reductase Not Available 0.0104
2931 Dihydrofolate reductase folA 0.0104
3544 Dihydrofolate reductase folA 0.0104
3682 Dihydrofolate reductase folA 0.0104
6642 Dihydrofolate reductase folA 0.0104
6756 Dihydrofolate reductase dfrA 0.0104
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0104
322 Vasopressin V2 receptor AVPR2 0.0104
3312 Fatty acid-binding protein, brain FABP7 0.0104
6163 Copper-transporting ATPase 2 ATP7B 0.0104
6165 Copper-transporting ATPase 1 ATP7A 0.0104
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0103
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0103
2240 Cell division protein kinase 2 CDK2 0.0102
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0102
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0102
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0101
1770 Phospholipase C PLCL1 0.0101
2841 Phospholipase C plc 0.0101
295 Carbonic anhydrase 1 CA1 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
1830 5'-nucleotidase NT5E 0.01
469 Annexin A1 ANXA1 0.01
239 Coagulation factor X F10 0.0099
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0099
694 Matrix protein 2 M 0.0098
153 Dopamine beta-hydroxylase DBH 0.0098
2449 Tubulin alpha-3 chain TUBA1A 0.0098
6599 HTH-type transcriptional regulator ttgR ttgR 0.0097
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
537 ATP synthase delta chain, mitochondrial ATP5D 0.0096
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0096
459 Retinoic acid receptor RXR-alpha RXRA 0.0096
4192 DNA topoisomerase 2-beta TOP2B 0.0096
49 Endothelin B receptor EDNRB 0.0096
164 Histamine H4 receptor HRH4 0.0095
3611 Cytidine deaminase cdd 0.0095
3707 Cytidine deaminase cdd 0.0095
4211 Cytidine deaminase CDA 0.0095
566 Serotransferrin TF 0.0094
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0094
4238 50S ribosomal protein L4 rplD 0.0094
5578 50S ribosomal protein L4 rplD 0.0094
6173 50S ribosomal protein L4 rplD 0.0094
6219 50S ribosomal protein L4 rplD 0.0094
6171 Solute carrier family 28 member 3 SLC28A3 0.0094
5923 Microtubule-associated protein tau MAPT 0.0094
5924 Microtubule-associated protein 4 MAP4 0.0094
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0093
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0093
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0093
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0093
244 Angiotensin-converting enzyme ACE 0.0092
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
4122 Histone deacetylase 2 HDAC2 0.0092
896 Glutathione S-transferase Mu 1 GSTM1 0.0092
106 Cannabinoid receptor 2 CNR2 0.0092
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0092
1650 Heme carrier protein 1 SLC46A1 0.0091
5300 Antigen peptide transporter 1 TAP1 0.009
578 Endothelin-1 receptor EDNRA 0.009
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0089
2183 Fatty acid-binding protein, adipocyte FABP4 0.0089
828 Phenylalanine-4-hydroxylase PAH 0.0089
3109 Phenylalanine-4-hydroxylase phhA 0.0089
208 DNA-directed RNA polymerase beta' chain rpoC 0.0088
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0088
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0088
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0087
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0086
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0086
24 Thymidylate synthase TMP1 0.0086
359 Thymidylate synthase TYMS 0.0086
2626 Thymidylate synthase thyA 0.0086
2729 Thymidylate synthase thyA 0.0086
5352 Thymidylate synthase THYA 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0085
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0084
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0084
1341 Histamine H3 receptor HRH3 0.0083
780 Retinoic acid receptor RXR-gamma RXRG 0.0082
527 Prostacyclin receptor PTGIR 0.0082
2616 Ganglioside GM2 activator GM2A 0.0082
357 Carbonic anhydrase 2 CA2 0.0082
702 UMP-CMP kinase CMPK1 0.0082
6167 Organic solute transporter subunit beta OSTB 0.0082
921 Glutamate receptor 2 GRIA2 0.0081
6166 Organic solute transporter subunit alpha OSTA 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0081
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0081
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0081
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0081
814 Ryanodine receptor 1 RYR1 0.0081
125 DNA polymerase beta POLB 0.0081
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
2112 Toll-like receptor 9 TLR9 0.008
6111 DNA polymerase epsilon subunit 4 POLE4 0.008
6112 DNA polymerase epsilon subunit 3 POLE3 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.008
6110 DNA polymerase epsilon subunit 2 POLE2 0.008
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.008
6109 DNA polymerase epsilon catalytic subunit A POLE 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
751 Potassium channel subfamily K member 6 KCNK6 0.0079
3932 Glutathione S-transferase A2 GSTA2 0.0079
173 Toll-like receptor 7 TLR7 0.0079
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
4217 Telomerase reverse transcriptase TERT 0.0078
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0077
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
319 Opioid receptor, sigma 1 OPRS1 0.0077
1648 Elastin ELN 0.0076
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0076
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0075
88 Retinoic acid receptor RXR-beta RXRB 0.0075
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0075
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0074
54 Prothrombin F2 0.0074
6044 Serum paraoxonase/lactonase 3 PON3 0.0074
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0073
489 Monocarboxylate transporter 2 SLC16A7 0.0073
172 Potassium channel subfamily K member 1 KCNK1 0.0073
4103 Proteasome subunit beta type 2 PSMB2 0.0073
4102 Proteasome subunit beta type 5 PSMB5 0.0073
4101 Proteasome subunit beta type 1 PSMB1 0.0073
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0072
4116 Dihydropteroate synthetase Not Available 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
130 Prostacyclin synthase PTGIS 0.0072
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
2300 Lysozyme E 0.0071
3633 Lysozyme R 0.0071
5597 Lysozyme 17 0.0071
284 DNA-directed RNA polymerase beta chain rpoB 0.0071
5773 DNA-directed RNA polymerase beta chain rpoB 0.0071
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0071
5626 Nucleoside diphosphate kinase B NME2 0.0071
3601 Dihydropteroate synthase 1 folP1 0.007
3807 Dihydropteroate synthase 1 folP1 0.007
3808 Dihydropteroate synthase 2 folP2 0.007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.007
6103 Arylamine N-acetyltransferase 1 NAT1 0.007
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.007
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.007
5294 Nucleoside diphosphate kinase A NME1 0.0069
1360 Sphingomyelin phosphodiesterase SMPD1 0.0069
1525 Heparin-binding growth factor 2 FGF2 0.0069
84 Nuclear receptor 0B1 NR0B1 0.0068
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0068
634 Squalene monooxygenase SQLE 0.0067
7196 Squalene monooxygenase ERG1 0.0067
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
342 P protein [Includes: DNA-directed DNA polymerase P 0.0067
612 P protein [Includes: DNA-directed DNA polymerase P 0.0067
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0067
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0066
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
340 Apoptotic protease-activating factor 1 APAF1 0.0065
2499 Tubulin beta-2C chain TUBB2C 0.0065
1196 Complement decay-accelerating factor CD55 0.0065
4210 Toll-like receptor 4 TLR4 0.0065
5126 Arginase rocF 0.0064
1275 Estrogen sulfotransferase SULT1E1 0.0064
174 Sigma 1-type opioid receptor SIGMAR1 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4311 tRNA TRDMT1 0.0063
4325 tRNA trmD 0.0063
4328 tRNA trmD 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0063
133 Dihydropterate synthase sulI 0.0063
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0062
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
3917 Methylenetetrahydrofolate reductase MTHFR 0.0062
1714 Mitogen-activated protein kinase 3 MAPK3 0.0061
2320 Thymidine kinase, cytosolic TK1 0.0061
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0061
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0061
5934 Cytochrome P450 26A1 CYP26A1 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
3809 Estrogen-related receptor gamma ESRRG 0.006
6126 Carbonic anhydrase 7 CA7 0.006
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
2981 Phospholipase A2, membrane associated PLA2G2A 0.0058
1483 Membrane copper amine oxidase AOC3 0.0057
518 Peroxidase/catalase T katG 0.0057
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
1630 Integrin beta-2 ITGB2 0.0057
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0056
2808 Chloramphenicol acetyltransferase 3 cat3 0.0056
703 NADPH azoreductase azr 0.0056
6174 50S ribosomal protein L32 rpmF 0.0056
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0056
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0056
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0056
6218 Pannexin-1 PANX1 0.0056
6755 Poliovirus receptor PVR 0.0055
6228 Nuclear receptor coactivator 1 NCOA1 0.0055
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0055
6506 Stathmin-4 STMN4 0.0055
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0054
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0054
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0054
6033 High affinity interleukin-8 receptor A CXCR1 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
594 Thyroxine-binding globulin SERPINA7 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6138 Multidrug resistance protein 3 ABCB4 0.0053
856 Vitamin D3 receptor VDR 0.0053
712 Tubulin alpha chain TUB1 0.0052
6211 Tubulin epsilon chain TUBE1 0.0052
6212 Tubulin gamma-1 chain TUBG1 0.0052
6210 Tubulin delta chain TUBD1 0.0052
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
65 Matrix metalloproteinase-9 Not Available 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
2810 Dr hemagglutinin structural subunit draA 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
162 Retinoic acid receptor gamma-1 RARG 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0049
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0049
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0049
758 Thyroid hormone receptor alpha THRA 0.0049
563 Thyroid peroxidase TPO 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
1992 Vitamin D-binding protein GC 0.0047
5682 Ribonuclease pancreatic RNASE1 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
1374 Natriuretic peptides B NPPB 0.0047
683 Potassium transporter GK0582 0.0047
1827 Gap junction alpha-1 protein GJA1 0.0046
1908 Vascular cell adhesion protein 1 VCAM1 0.0046
277 Purine nucleoside phosphorylase PNP 0.0046
2870 Purine nucleoside phosphorylase punA 0.0046
2945 Purine nucleoside phosphorylase punA 0.0046
4659 Purine nucleoside phosphorylase TM_1596 0.0046
4825 Purine nucleoside phosphorylase TTHA1435 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
394 Calcineurin subunit B isoform 1 PPP3R1 0.0046
6753 Apolipoprotein M APOM 0.0046
6743 Non-fluorescent flavoprotein luxF 0.0046
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0046
6742 Recoverin RCVRN 0.0046
6747 Chalcone/stilbene synthase family protein MT1417 0.0046
2528 Fatty acid metabolism regulator protein fadR 0.0046
6740 Fatty acid metabolism regulator protein fadR 0.0046
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0046
6751 Gag polyprotein gag 0.0046
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0046
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0046
6749 Polyprotein Not Available 0.0046
3086 Plasmepsin-2 Not Available 0.0046
2207 Rhodopsin RHO 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
292 Activin receptor type-1 ACVR1 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
849 Activated CDC42 kinase 1 TNK2 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
707 72 kDa type IV collagenase MMP2 0.0044
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0043
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0043
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
572 Integrin alpha-L ITGAL 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0042
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0042
395 ALK tyrosine kinase receptor Not Available 0.0042
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0042
733 Activin receptor type 1B ACVR1B 0.0042
825 Arsenical pump-driving ATPase ASNA1 0.0042
3435 Arsenical pump-driving ATPase arsA 0.0042
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0042
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0042
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0042
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0042
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0042
154 AFG3-like protein 2 AFG3L2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0042
3957 Adenosine deaminase ADA 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
6048 Troponin C, skeletal muscle TNNC2 0.0041
293 Gamma-glutamyl hydrolase GGH 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0041
5961 Insulin INS 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
6527 Lymphocyte antigen 96 LY96 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
4161 Furin FURIN 0.004
4225 Uridine phosphorylase 1 UPP1 0.004
2021 Thrombomodulin THBD 0.004
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0039
581 Cytochrome P450 2R1 CYP2R1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
1541 Metalloproteinase mmp20 0.0039
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0038
6677 Myelin P2 protein PMP2 0.0038
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
233 Potassium channel subfamily K member 2 KCNK2 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
6750 ADP-ribosylation factor 6 ARF6 0.0038
85 Growth hormone receptor GHR 0.0038
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0037
661 ADP/ATP translocase 1 SLC25A4 0.0037
6524 Protein tonB tonB 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0037
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0037
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0037
297 Adenylate cyclase type 1 ADCY1 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
595 Fibrinogen alpha chain FGA 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
2091 Endoplasmin HSP90B1 0.0035
6316 ADP-ribosylation factor 1 ARF1 0.0035
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0035
822 Aldose reductase AKR1B1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
1039 Histone deacetylase 9 HDAC9 0.0035
229 Retinoic acid receptor beta RARB 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0034
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0034
730 Retinoic acid receptor alpha RARA 0.0033
6021 Adenosine kinase ADK 0.0033
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
1867 Major prion protein PRNP 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
3937 Fatty-acid amide hydrolase FAAH 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
6131 Carbonic anhydrase 14 CA14 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
199 Monocarboxylate transporter 8 SLC16A2 0.0031
2236 Casein kinase II subunit alpha CSNK2A1 0.0031
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
740 Argininosuccinate synthase ASS1 0.0031
865 Argininosuccinate synthase ASS1 0.0031
2680 Argininosuccinate synthase argG 0.0031
3194 Argininosuccinate synthase argG 0.0031
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
864 Gag-Pol polyprotein gag-pol 0.003
2237 Gag-Pol polyprotein gag-pol 0.003
2326 Gag-Pol polyprotein gag-pol 0.003
2451 Gag-Pol polyprotein gag-pol 0.003
2901 Gag-Pol polyprotein gag-pol 0.003
3165 Gag-Pol polyprotein gag-pol 0.003
3722 Gag-Pol polyprotein gag-pol 0.003
6306 Gag-Pol polyprotein gag-pol 0.003
6624 Gag-Pol polyprotein gag-pol 0.003
6042 Prostaglandin reductase 2 PTGR2 0.003
719 Retinoic acid receptor responder protein 1 RARRES1 0.003
770 Retinoic acid-induced protein 3 GPRC5A 0.003
3587 Gastrotropin FABP6 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
6500 Phospholipase A2 PLA2G1B 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
291 Nitric-oxide synthase, endothelial NOS3 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
2427 Ferrichrome-iron receptor fhuA 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1792 Tissue-type plasminogen activator PLAT 0.0028
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0027
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0027
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0027
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0027
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0027
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6837 Serine/threonine-protein kinase 17B STK17B 0.0025
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0025
6151 Monocarboxylate transporter 10 SLC16A10 0.0025
3830 Calreticulin CALR 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
444 Alcohol dehydrogenase 1B ADH1B 0.0025
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0025
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
3616 Fatty acid-binding protein, epidermal FABP5 0.0024
5431 Lipid binding protein Not Available 0.0024
5433 UPF0230 protein TM_1468 TM_1468 0.0024
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0024
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0024
6459 Glycodelin PAEP 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
1313 Lactoylglutathione lyase GLO1 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
3404 Exotoxin A eta 0.0022
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
5818 Folate receptor alpha FOLR1 0.0021
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
268 Adenosine A2b receptor ADORA2B 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
517 Alcohol dehydrogenase 1C ADH1C 0.002
5189 Trimethylamine dehydrogenase tmd 0.002
1268 Neuropeptide S receptor NPSR1 0.002
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.002
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
4837 Cag-alfa cag-alfa 0.002
5646 Galactokinase GALK1 0.002
3390 Aminoglycoside 3'-phosphotransferase aphA 0.002
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.002
5302 TrwB trwB 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
5265 FtsH ftsH 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
2270 Dephospho-CoA kinase coaE 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
283 SEC14-like protein 2 SEC14L2 0.002
1881 Hexokinase-1 HK1 0.002
1820 Beta-nerve growth factor NGF 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
1058 Cell division protein kinase 5 CDK5 0.002
1243 Cathepsin D CTSD 0.0019
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0019
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0019
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6168 Solute carrier family 22 member 16 SLC22A16 0.0019
76 Nitric-oxide synthase, brain NOS1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
5312 Kinesin-like protein KIF1A KIF1A 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
2922 Glycerol kinase glpK 0.0018
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0018
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0018
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1721 Glycogen synthase kinase-3 beta GSK3B 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0017
2615 Chemotaxis protein cheA cheA 0.0017
2371 Pantothenate kinase coaA 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
2892 Acetylglutamate kinase argB 0.0017
3550 Acetylglutamate kinase argB 0.0017
3669 Ribokinase rbsK 0.0017
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0016
788 Creatine kinase M-type CKM 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
2697 Uridine-cytidine kinase 2 UCK2 0.0015
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0015
3233 Bile acid receptor NR1H4 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1152 Glycogen phosphorylase, muscle form PYGM 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
48 Pyridoxal kinase PDXK 0.0015
3221 Cytochrome c4 cc4 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
207 Glutathione synthetase GSS 0.0014
5269 Glutathione synthetase gshB 0.0014
3379 Kinesin-like protein KIF11 KIF11 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
4948 Cytochrome c-553 Not Available 0.0013
4923 Cytochrome c3 DvMF_2499 0.0013
4945 Cytochrome c3 Not Available 0.0013
4949 Cytochrome c3 DVU_3171 0.0013
4968 Cytochrome c3 cytc3 0.0013
4997 Cytochrome c3 SO_2727 0.0013
5219 Cytochrome c3 cyd 0.0013
4902 Nine-heme cytochrome c Ddes_2038 0.0013
3189 High-molecular-weight cytochrome c hmcA 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4386 Hemoglobin-like protein HbN glbN 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
2298 Cytochrome P450-cam camC 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4943 Cytochrome c6 petJ 0.0009
4954 Soluble cytochrome b558 Not Available 0.0009
4916 Cyanoglobin glbN 0.0009
4934 Cytochrome c-551 nirM 0.0009
5218 Cytochrome c-551 nirM 0.0009
4905 Cytochrome c2 Not Available 0.0009
4939 Cytochrome c2 cycA 0.0009
4964 Cytochrome c2 cycA 0.0009
4979 Cytochrome c2 cycA 0.0009
6673 Cytochrome c2 cycA 0.0009
4947 Bacterial hemoglobin vhb 0.0009
4994 Hemoglobin-like protein HbO glbO 0.0009
4942 Diheme cytochrome c napB napB 0.0009
4915 Cytochrome c-550 psbV 0.0009
4959 Cytochrome c-550 psbV 0.0009
5216 Cytochrome c-550 psbV 0.0009
4925 Cytochrome c-type protein SHP shp 0.0009
4984 Neuroglobin NGB 0.0009
4975 Cytochrome c-556 RPA3973 0.0009
4981 Iron-starvation protein PigA pigA 0.0009
5000 HemO hemO 0.0009
4936 Cytochrome c2 iso-2 Not Available 0.0009
4998 Hemoglobin-like protein yjbI yjbI 0.0009
4961 Hemophore HasA hasA 0.0009
4909 CooA protein cooA 0.0009
4910 Cytoglobin CYGB 0.0009
4935 Cytochrome c-554 cycA1 0.0009
644 Heme oxygenase 2 HMOX2 0.0009
4982 Heme oxygenase 2 pbsA2 0.0009
4907 Cytochrome c-L moxG 0.0009
6865 Cytochrome c-L moxG 0.0009
4976 Apocytochrome f petA 0.0009
6407 Apocytochrome f petA 0.0009
4971 Nonaheme cytochrome c hmcA 0.0009
4937 Cytochrome oxidase subunit II rcoxA 0.0009
4904 Cytochrome c family protein GSU1996 0.0009
4989 Cytochrome c551 peroxidase ccp 0.0009
5222 Cytochrome c551 peroxidase ccpA 0.0009
4931 Cytochrome P450 167A1 CYP167A1 0.0009
4926 Heme-based aerotactic transducer hemAT hemAT 0.0009
4764 Cytochrome P450 165C4 CYP165C4 0.0009
4960 Putative cytochrome P450-family protein SCO7417 0.0009
4903 Methyl-accepting chemotaxis protein Tar4 0.0009
4999 Cytochrome P450 165B3 CYP165B3 0.0009
4972 P450cin cinA 0.0009
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0009
4952 Catalase/peroxidase katA 0.0009
4993 Hydroxylamine oxidoreductase hao1 0.0009
4922 Cytochrome c, putative SO_4144 0.0009
3093 Catalase HPII katE 0.0009
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2132 Protein S100-B S100B 0.0009
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4920 Peroxidase/catalase katG 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
4692 A/G-specific adenine glycosylase mutY 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2119 Cytochrome b5 CYB5A 0.0007
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0007
4990 PpcA ppcA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
2230 Catalase CAT 0.0007
3249 Catalase katA 0.0007
3625 Catalase katA 0.0007
4539 Catalase katA 0.0007
4941 Catalase katB 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
2802 Endoglucanase G celCCG 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
3670 Soluble cytochrome b562 precursor cybC 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
2617 Nitric oxide synthase oxygenase nos 0.0006
2701 Nitric oxide synthase oxygenase nos 0.0006
3291 Cytochrome c-552 cycA 0.0006
4927 Cytochrome c-552 nrfA 0.0006
4938 Cytochrome c-552 cycA 0.0006
4953 Cytochrome c-552 nrfA 0.0006
5217 Cytochrome c-552 cycM 0.0006
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
798 Osteocalcin BGLAP 0.0005
4608 Putative cytochrome P450 SCO1207 0.0005
4963 Putative cytochrome P450 SCO2884 0.0005
6254 Putative cytochrome P450 SCO6998 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
358 Cystathionine beta-synthase CBS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
369 Coagulation factor VII F7 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
693 Hemoglobin subunit beta HBB 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
2581 Chondroitinase AC cslA 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
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