DT-Web: DB00541

Identification

Name

Vincristine

Accession Number

DB00541 (APRD00495)

Type

small molecule

Description

Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

824.9576

Groups

approved

Monoisotopic Weight

824.399644032

Pharmacology

Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis.

Mechanism of action

The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca²⁺-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.

Absorption

Not Available

Protein binding

~75%

Biotransformation

Hepatic

Route of elimination

Not Available

Toxicity

IVN-RAT LD₅₀ 1300 mg/kg; IPR-MUS LD₅₀ 5.2 mg/kg. Marqibo(R) must only be administered IV because it is fatal if administered by other routes. Marqibo(R) also has different dosing than vincristine sulphate injection, so attention is needed to prevent overdoses.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amprenavir	Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Amprenavir is initiated, discontinued or dose changed.
Aprepitant	Aprepitant may change levels of the chemotherapy agent, vincristine.
Atazanavir	Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Atazanavir is initiated, discontinued or dose changed.
Clarithromycin	Clarithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Clarithromycin is initiated, discontinued or dose changed.
Conivaptan	Conivaptan, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Conivaptan is initiated, discontinued or dose changed.
Darunavir	Darunavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Darunavir is initiated, discontinued or dose changed.
Delavirdine	Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Delavirdine is initiated, discontinued or dose changed.
Digoxin	The antineoplasic agent decreases the effect of digoxin
Dirithromycin	Dirithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Dirithromycin is initiated, discontinued or dose changed.
Erythromycin	Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Erythromycin is initiated, discontinued or dose changed.
Etravirine	Vincristine, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Fluconazole	Increases the effect and toxicity of anticancer agent
Fosamprenavir	Fosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Fosamprenavir is initiated, discontinued or dose changed.
Imatinib	Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Imatinib is initiated, discontinued or dose changed.
Indinavir	Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Indinavir is initiated, discontinued or dose changed.
Isoniazid	Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Isoniazid is initiated, discontinued or dose changed.
Itraconazole	Itraconazole, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism and/or increasing efflux. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Itraconazole is initiated, discontinued or dose changed.
Ketoconazole	Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Ketoconazole is initiated, discontinued or dose changed.
Leflunomide	Vincristine may increase the adverse/toxic effects of Leflunomide. This may increase the risk of hematologic toxicities such as pancytopenia, agranulocytosis and thrombocytopenia. In patients receiving Vincristine, consider eliminating the loading dose of Leflunomide. Monitor for bone marrow suppression at least monthly during concomitant therapy.
Lopinavir	Lopinavir, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism and/or increasing its efflux. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Lopinavir is initiated, discontinued or dose changed.
Miconazole	Miconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Miconazole is initiated, discontinued or dose changed.
Mitomycin	Potentially severe lung toxicity
Natalizumab	Concomitant Vincristine and Natalizumab therapy may increase the risk of infection. Concurrent therapy should be avoided.
Nefazodone	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Nefazodone is initiated, discontinued or dose changed.
Nelfinavir	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Nelfinavir is initiated, discontinued or dose changed.
Nicardipine	Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Nicardipine is initiated, discontinued or dose changed.
Posaconazole	Posaconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Posaconazole is initiated, discontinued or dose changed.
Quinidine	Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Quinidine is initiated, discontinued or dose changed.
Quinupristin	This combination presents an increased risk of toxicity
Ritonavir	Ritonavir, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism and/or increasing efflux. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Ritonavir is initiated, discontinued or dose changed.
Saquinavir	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Saquinavir is initiated, discontinued or dose changed.
Spiramycin	Spiramycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Spiramycin is initiated, discontinued or dose changed.
Telithromycin	Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Telithromycin is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Voriconazole is initiated, discontinued or dose changed.

Food Interactions

Not Available

Tubulin beta chain
Name	Tubulin beta chain
Gene Name	TUBB
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kurtzberg LS, Roth SD, Bagley RG, Rouleau C, Yao M, Crawford JL, Krumbholz RD, Schmid SM, Teicher BA: Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents. Cancer Chemother Pharmacol. 2009 Oct;64(5):1029-38. Epub 2009 Mar 10. - Pubmed Gan PP, McCarroll JA, Po'uha ST, Kamath K, Jordan MA, Kavallaris M: Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin. Mol Cancer Ther. 2010 May;9(5):1339-48. Epub 2010 May 4. - Pubmed
DTHybrid score	0.3391
Tubulin alpha-1 chain
Name	Tubulin alpha-1 chain
Gene Name	TUBA4A
Pharmacological action	unknown
Actions	inhibitor
References	Yasui M, Koyama N, Koizumi T, Senda-Murata K, Takashima Y, Hayashi M, Sugimoto K, Honma M: Live cell imaging of micronucleus formation and development. Mutat Res. 2010 Oct 13;692(1-2):12-8. Epub 2010 Aug 5. - Pubmed Gan PP, McCarroll JA, Po'uha ST, Kamath K, Jordan MA, Kavallaris M: Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin. Mol Cancer Ther. 2010 May;9(5):1339-48. Epub 2010 May 4. - Pubmed Vilpo JA, Koski T, Vilpo LM: Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. Eur J Haematol. 2000 Dec;65(6):370-8. - Pubmed
DTHybrid score	0.301

Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4878
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3748
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7569

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Arora A, Shukla Y: Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. Cancer Lett. 2003 Jan 28;189(2):167-73. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed Doppenschmitt S, Langguth P, Regardh CG, Andersson TB, Hilgendorf C, Spahn-Langguth H: Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay. J Pharmacol Exp Ther. 1999 Jan;288(1):348-57. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Li D, Jang SH, Kim J, Wientjes MG, Au JL: Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res. 2003 Jan;20(1):45-50. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY: BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res. 2004 Jul 1;64(13):4621-8. - Pubmed Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ: MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. Epub 2009 Jan 4. - Pubmed Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
DTHybrid score	0.6412
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed
DTHybrid score	0.2202
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Shnitsar V, Eckardt R, Gupta S, Grottker J, Muller GA, Koepsell H, Burckhardt G, Hagos Y: Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine. Cancer Res. 2009 Feb 15;69(4):1494-501. Epub 2009 Feb 3. - Pubmed
DTHybrid score	0.2094
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor
References	Loe DW, Almquist KC, Cole SP, Deeley RG: ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem. 1996 Apr 19;271(16):9683-9. - Pubmed Godinot N, Iversen PW, Tabas L, Xia X, Williams DC, Dantzig AH, Perry WL 3rd: Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. Mol Cancer Ther. 2003 Mar;2(3):307-16. - Pubmed Nunoya K, Grant CE, Zhang D, Cole SP, Deeley RG: Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab Dispos. 2003 Aug;31(8):1016-26. - Pubmed Sumizawa T, Chen ZS, Chuman Y, Seto K, Furukawa T, Haraguchi M, Tani A, Shudo N, Akiyama SI: Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. Mol Pharmacol. 1997 Mar;51(3):399-405. - Pubmed Renes J, de Vries EG, Nienhuis EF, Jansen PL, Muller M: ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br J Pharmacol. 1999 Feb;126(3):681-8. - Pubmed Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. - Pubmed
DTHybrid score	0.3664
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	substrate,inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. - Pubmed
DTHybrid score	0.1931
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003 Oct 10;310(1):222-7. - Pubmed Ishikawa T, Muller M, Klunemann C, Schaub T, Keppler D: ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem. 1990 Nov 5;265(31):19279-86. - Pubmed Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama SI: Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol. 1999 Dec;56(6):1219-28. - Pubmed
DTHybrid score	0.4024
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate
References	Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score	0.2729
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Allen JD, Van Dort SC, Buitelaar M, van Tellingen O, Schinkel AH: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer Res. 2003 Mar 15;63(6):1339-44. - Pubmed
DTHybrid score	0.4006

Id	Partner name	Gene Name	Score
312	Tubulin beta chain	TUB2	0.3391
4119	Cytochrome P450 2D6	CYP2D6	0.2881
4757	Cytochrome P450 2C9	CYP2C9	0.2691
6016	Cytochrome P450 2C19	CYP2C19	0.2644
4924	Cytochrome P450 2C8	CYP2C8	0.2516
4200	Cytochrome P450 1A2	CYP1A2	0.2235
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1647
6030	Cytochrome P450 2B6	CYP2B6	0.1594
29	Tubulin beta-1 chain	TUBB1	0.1558
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1467
817	DNA topoisomerase 2-alpha	TOP2A	0.1342
6144	Solute carrier family 22 member 2	SLC22A2	0.1337
6013	Cytochrome P450 2E1	CYP2E1	0.1336
6145	Solute carrier family 22 member 1	SLC22A1	0.1335
6024	Cytochrome P450 1A1	CYP1A1	0.1264
2164	Multidrug resistance-associated protein 4	ABCC4	0.1261
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1203
1729	Solute carrier family 22 member 6	SLC22A6	0.1056
2601	Tubulin alpha-2 chain	TUBA3C	0.1056
2449	Tubulin alpha-3 chain	TUBA1A	0.1053
587	Serum albumin	ALB	0.105
2480	Tubulin alpha-8 chain	TUBA8	0.1043
2565	Tubulin beta-4 chain	TUBB4	0.1038
2444	Tubulin beta-4q chain	TUBB4Q	0.1012
2342	Tubulin alpha-ubiquitous chain	TUBA1B	0.0998
2536	Tubulin alpha-6 chain	TUBA1C	0.0997
2578	Tubulin beta-3 chain	TUBB3	0.0979
1898	Cytochrome P450 1B1	CYP1B1	0.0956
6137	Multidrug resistance-associated protein 6	ABCC6	0.0876
2499	Tubulin beta-2C chain	TUBB2C	0.0867
6142	Solute carrier family 22 member 8	SLC22A8	0.0863
6141	Sodium/bile acid cotransporter	SLC10A1	0.0831
118	Organic cation/carnitine transporter 2	SLC22A5	0.0816
5718	Cytochrome P450 2A6	CYP2A6	0.0805
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.071
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0703
6143	Solute carrier family 22 member 7	SLC22A7	0.0663
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.065
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0556
833	Organic cation/carnitine transporter 1	SLC22A4	0.0514
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0496
136	Estrogen receptor	ESR1	0.0493
6106	Cytochrome P450 2C18	CYP2C18	0.0492
3811	Cytochrome P450 19A1	CYP19A1	0.0476
20	Prostaglandin G/H synthase 1	PTGS1	0.0459
1024	Solute carrier family 22 member 11	SLC22A11	0.0457
6136	Multidrug resistance-associated protein 5	ABCC5	0.0455
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0455
731	HIV-1 protease	HIV-1 protease	0.043
871	Glucocorticoid receptor	NR3C1	0.0427
824	Sodium-dependent serotonin transporter	SLC6A4	0.0408
556	Alpha-1A adrenergic receptor	ADRA1A	0.0403
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0403
492	Histamine H1 receptor	HRH1	0.0396
6031	Cytochrome P450 3A43	CYP3A43	0.0394
4773	Deoxycytidine kinase	DCK	0.039
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0387
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0386
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.038
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0373
24	Thymidylate synthase	TMP1	0.0357
359	Thymidylate synthase	TYMS	0.0357
2626	Thymidylate synthase	thyA	0.0357
2729	Thymidylate synthase	thyA	0.0357
5352	Thymidylate synthase	THYA	0.0357
847	Mu-type opioid receptor	OPRM1	0.0356
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0355
5626	Nucleoside diphosphate kinase B	NME2	0.0351
6138	Multidrug resistance protein 3	ABCB4	0.0344
614	Progesterone receptor	PGR	0.0343
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0335
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0332
4120	NADPH--cytochrome P450 reductase	POR	0.0328
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0327
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0327
1852	Microtubule-associated protein 2	MAP2	0.0318
5923	Microtubule-associated protein tau	MAPT	0.0318
5924	Microtubule-associated protein 4	MAP4	0.0318
6211	Tubulin epsilon chain	TUBE1	0.0313
738	Monocarboxylate transporter 1	SLC16A1	0.0313
6210	Tubulin delta chain	TUBD1	0.0313
6212	Tubulin gamma-1 chain	TUBG1	0.0313
831	D(2) dopamine receptor	DRD2	0.0311
468	Cytochrome P450 4A11	CYP4A11	0.0308
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0303
318	Alpha-2A adrenergic receptor	ADRA2A	0.0301
290	Prostaglandin G/H synthase 2	PTGS2	0.03
320	5-hydroxytryptamine 1A receptor	HTR1A	0.03
844	Epidermal growth factor receptor	EGFR	0.0294
273	Apoptosis regulator Bcl-2	BCL2	0.0294
3923	Cholinesterase	BCHE	0.0294
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0292
4604	Liver carboxylesterase 1	CES1	0.0292
378	Alpha-2C adrenergic receptor	ADRA2C	0.029
908	Glutathione S-transferase theta-1	GSTT1	0.0288
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0282
5294	Nucleoside diphosphate kinase A	NME1	0.0281
4192	DNA topoisomerase 2-beta	TOP2B	0.028
477	DNA topoisomerase 4 subunit A	parC	0.028
886	DNA topoisomerase 4 subunit A	parC	0.028
6226	DNA topoisomerase 4 subunit A	parC	0.028
3947	Xanthine dehydrogenase/oxidase	XDH	0.0279
1353	DNA topoisomerase 1	TOP1	0.0278
3552	DNA topoisomerase 1	topA	0.0278
404	DNA gyrase subunit A	gyrA	0.0275
6224	DNA gyrase subunit A	gyrA	0.0275
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0273
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0272
33	Cystine/glutamate transporter	SLC7A11	0.0269
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0267
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0267
1629	Transcription factor AP-1	JUN	0.0266
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0263
632	Alpha-1B adrenergic receptor	ADRA1B	0.0257
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0257
504	Mast/stem cell growth factor receptor	KIT	0.0256
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0256
467	Delta-type opioid receptor	OPRD1	0.0252
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0251
260	Cytochrome P450 51	ERG11	0.025
761	Cytochrome P450 51	ERG11	0.025
3163	Cytochrome P450 51	cyp51	0.025
737	Mineralocorticoid receptor	NR3C2	0.025
70	Type-1 angiotensin II receptor	AGTR1	0.0248
904	Glutathione S-transferase P	GSTP1	0.0247
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0245
713	Sodium-dependent dopamine transporter	SLC6A3	0.0244
702	UMP-CMP kinase	CMPK1	0.0241
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0241
766	Beta-2 adrenergic receptor	ADRB2	0.0241
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.024
629	Alpha-2B adrenergic receptor	ADRA2B	0.0238
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0233
3611	Cytidine deaminase	cdd	0.0223
3707	Cytidine deaminase	cdd	0.0223
4211	Cytidine deaminase	CDA	0.0223
131	Synaptic vesicular amine transporter	SLC18A2	0.022
696	Kappa-type opioid receptor	OPRK1	0.0219
756	Sex hormone-binding globulin	SHBG	0.0218
6167	Organic solute transporter subunit beta	OSTB	0.0217
6166	Organic solute transporter subunit alpha	OSTA	0.0217
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0216
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0213
1650	Heme carrier protein 1	SLC46A1	0.0213
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0211
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0211
6182	Cytochrome P450 2J2	CYP2J2	0.0211
380	Cytochrome P450 17A1	CYP17A1	0.021
2808	Chloramphenicol acetyltransferase 3	cat3	0.021
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0208
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0207
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0207
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0206
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0204
683	Potassium transporter	GK0582	0.0203
789	Alpha-1D adrenergic receptor	ADRA1D	0.0201
869	Estrogen receptor beta	ESR2	0.02
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0199
23	D(1A) dopamine receptor	DRD1	0.0199
638	D(3) dopamine receptor	DRD3	0.0197
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0197
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0196
6085	Fatty acid-binding protein, intestinal	FABP2	0.0194
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0193
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0192
3868	Calcineurin subunit B isoform 2	PPP3R2	0.019
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.019
193	Beta-1 adrenergic receptor	ADRB1	0.0189
407	Vascular endothelial growth factor receptor 2	KDR	0.0189
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0188
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0187
117	Sterol O-acyltransferase 1	SOAT1	0.0185
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0184
3587	Gastrotropin	FABP6	0.0184
26	Vascular endothelial growth factor receptor 3	FLT4	0.0182
3270	Elongation factor G	fusA	0.0181
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0181
465	Calmodulin	CALM1	0.018
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.018
3941	Amine oxidase [flavin-containing] A	MAOA	0.0178
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0176
293	Gamma-glutamyl hydrolase	GGH	0.0175
32	Vascular endothelial growth factor receptor 1	FLT1	0.0174
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0174
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0172
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0164
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0163
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0163
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0162
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0162
165	FL cytokine receptor	FLT3	0.016
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0158
124	Histamine H2 receptor	HRH2	0.0157
887	DNA gyrase subunit B	gyrB	0.0156
4150	DNA gyrase subunit B	gyrB	0.0156
6225	DNA gyrase subunit B	gyrB	0.0156
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0154
232	Corticosteroid-binding globulin	SERPINA6	0.0154
952	Dipeptidyl peptidase 4	DPP4	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0153
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0153
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0153
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0152
450	Muscarinic acetylcholine receptor M4	CHRM4	0.015
896	Glutathione S-transferase Mu 1	GSTM1	0.015
590	5-hydroxytryptamine 2C receptor	HTR2C	0.015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0149
6163	Copper-transporting ATPase 2	ATP7B	0.0148
6165	Copper-transporting ATPase 1	ATP7A	0.0148
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0148
723	Cytosolic phospholipase A2	PLA2G4A	0.0147
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
6146	High affinity copper uptake protein 1	SLC31A1	0.0146
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0144
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0144
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0142
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0142
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.014
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0139
49	Endothelin B receptor	EDNRB	0.0139
6020	Aldehyde oxidase	AOX1	0.0138
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0138
5787	Angiopoietin-1 receptor	TEK	0.0137
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0136
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0136
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0136
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0135
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0135
6220	Aryl hydrocarbon receptor	AHR	0.0134
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0132
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0132
1757	Myeloperoxidase	MPO	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
578	Endothelin-1 receptor	EDNRA	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
4237	50S ribosomal protein L22	rplV	0.013
1830	5'-nucleotidase	NT5E	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
146	Androgen receptor	AR	0.0128
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0127
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0127
6149	Solute carrier family 22 member 10	SLC22A10	0.0127
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0126
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0126
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0126
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6168	Solute carrier family 22 member 16	SLC22A16	0.0125
3939	Amine oxidase [flavin-containing] B	MAOB	0.0124
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0124
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0123
125	DNA polymerase beta	POLB	0.0123
1636	Trace amine-associated receptor 1	TAAR1	0.0122
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
818	50S ribosomal protein L10	rplJ	0.0122
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0121
1760	Aminopeptidase N	ANPEP	0.012
6843	Aminopeptidase N	pepN	0.012
4238	50S ribosomal protein L4	rplD	0.012
5578	50S ribosomal protein L4	rplD	0.012
6173	50S ribosomal protein L4	rplD	0.012
6219	50S ribosomal protein L4	rplD	0.012
6171	Solute carrier family 28 member 3	SLC28A3	0.012
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.012
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0119
469	Annexin A1	ANXA1	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0118
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0117
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0117
432	D(4) dopamine receptor	DRD4	0.0117
7	Nitric oxide synthase, inducible	NOS2	0.0116
811	Translocator protein	TSPO	0.0116
275	Arachidonate 5-lipoxygenase	ALOX5	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0115
1192	Sulfotransferase 1A1	SULT1A1	0.0114
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0111
3809	Estrogen-related receptor gamma	ESRRG	0.011
5818	Folate receptor alpha	FOLR1	0.0109
992	Protein tyrosine kinase 2 beta	PTK2B	0.0109
2443	Azurin	azu	0.0108
284	DNA-directed RNA polymerase beta chain	rpoB	0.0108
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0108
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0106
777	Tumor necrosis factor	TNF	0.0106
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0105
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0104
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0103
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0102
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0101
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0099
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0099
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0098
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0098
373	Transthyretin	TTR	0.0098
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0097
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0097
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0096
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0096
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0096
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0096
1010	Cytochrome P450 51A1	CYP51A1	0.0096
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0095
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0095
3810	Catechol O-methyltransferase	COMT	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0094
299	Folate receptor beta	FOLR2	0.0093
718	Folate receptor gamma	FOLR3	0.0092
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0092
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
3856	Fibroblast growth factor receptor 3	FGFR3	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0091
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0091
716	5-hydroxytryptamine 7 receptor	HTR7	0.0091
474	Acetylcholinesterase	ACHE	0.0089
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0088
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0088
6014	Cytochrome P450 2A13	CYP2A13	0.0088
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0088
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0088
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0088
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0088
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0087
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0087
1050	Bile salt sulfotransferase	SULT2A1	0.0087
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0086
122	P2Y purinoceptor 12	P2RY12	0.0084
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0084
489	Monocarboxylate transporter 2	SLC16A7	0.0084
6070	Nischarin	NISCH	0.0083
84	Nuclear receptor 0B1	NR0B1	0.0083
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0082
76	Nitric-oxide synthase, brain	NOS1	0.0082
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
6043	Putative G-protein coupled receptor 44	GPR44	0.0081
365	Dihydrofolate reductase	DHFR	0.0079
2381	Dihydrofolate reductase	DFR1	0.0079
2833	Dihydrofolate reductase	Not Available	0.0079
2931	Dihydrofolate reductase	folA	0.0079
3544	Dihydrofolate reductase	folA	0.0079
3682	Dihydrofolate reductase	folA	0.0079
6642	Dihydrofolate reductase	folA	0.0079
6756	Dihydrofolate reductase	dfrA	0.0079
823	Fibroblast growth factor receptor 2	FGFR2	0.0079
4203	Histamine N-methyltransferase	HNMT	0.0079
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0079
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0079
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0079
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0078
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0078
291	Nitric-oxide synthase, endothelial	NOS3	0.0076
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0076
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0076
2472	Voltage-gated potassium channel	kcsA	0.0075
6366	Voltage-gated potassium channel	kcsA	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
239	Coagulation factor X	F10	0.0075
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0075
2298	Cytochrome P450-cam	camC	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
427	Substance-P receptor	TACR1	0.0074
163	D(1B) dopamine receptor	DRD5	0.0074
183	Vascular endothelial growth factor A	VEGFA	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
1517	Beta-3 adrenergic receptor	ADRB3	0.0073
1656	CYP2B protein	CYP2B	0.0073
6824	Tyrosine-protein kinase Lyn	LYN	0.0073
2391	Ferrochelatase	hemH	0.0072
6502	Ferrochelatase	DKFZp686P18130	0.0072
1591	Ferrochelatase, mitochondrial	FECH	0.0072
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0072
2216	Fibroblast growth factor receptor 4	FGFR4	0.0072
68	Cannabinoid receptor 1	CNR1	0.0071
2599	Tyrosine-protein kinase HCK	HCK	0.0071
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0071
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.007
6837	Serine/threonine-protein kinase 17B	STK17B	0.007
244	Angiotensin-converting enzyme	ACE	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0068
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0067
1313	Lactoylglutathione lyase	GLO1	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0066
6218	Pannexin-1	PANX1	0.0065
6432	Transporter	snf	0.0065
3932	Glutathione S-transferase A2	GSTA2	0.0064
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0064
164	Histamine H4 receptor	HRH4	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0063
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0063
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0063
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0063
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0063
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0063
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0063
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0062
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0062
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0062
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0062
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0062
6559	Cytochrome c oxidase subunit 2	ctaC	0.0062
6669	Cytochrome c oxidase subunit 2	ctaC	0.0062
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0062
6558	Cytochrome c oxidase subunit 1	ctaD	0.0062
1341	Histamine H3 receptor	HRH3	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0062
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0062
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0061
814	Ryanodine receptor 1	RYR1	0.0061
153	Dopamine beta-hydroxylase	DBH	0.0061
5126	Arginase	rocF	0.0061
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
4226	Uridine phosphorylase 2	UPP2	0.0059
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0059
2540	Choloylglycine hydrolase	cbh	0.0057
1618	High affinity nerve growth factor receptor	NTRK1	0.0057
484	Tyrosine-protein kinase ABL2	ABL2	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
94	5-hydroxytryptamine 4 receptor	HTR4	0.0056
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0056
921	Glutamate receptor 2	GRIA2	0.0056
6042	Prostaglandin reductase 2	PTGR2	0.0056
1630	Integrin beta-2	ITGB2	0.0055
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0055
4225	Uridine phosphorylase 1	UPP1	0.0055
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0054
6501	Fatty acid-binding protein, liver	FABP1	0.0054
319	Opioid receptor, sigma 1	OPRS1	0.0054
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0053
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0053
5300	Antigen peptide transporter 1	TAP1	0.0051
413	Amidophosphoribosyltransferase	PPAT	0.0051
2515	Amidophosphoribosyltransferase	purF	0.0051
3714	Amidophosphoribosyltransferase	purF	0.0051
751	Potassium channel subfamily K member 6	KCNK6	0.0051
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.005
936	Ephrin type-A receptor 2	EPHA2	0.0049
1483	Membrane copper amine oxidase	AOC3	0.0048
4122	Histone deacetylase 2	HDAC2	0.0048
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0048
6228	Nuclear receptor coactivator 1	NCOA1	0.0047
267	Plasminogen activator inhibitor 1	SERPINE1	0.0047
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0047
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0047
624	Guanidinoacetate N-methyltransferase	GAMT	0.0047
172	Potassium channel subfamily K member 1	KCNK1	0.0047
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
5934	Cytochrome P450 26A1	CYP26A1	0.0046
2232	Interleukin-5	IL5	0.0045
1593	Mucin-2	MUC2	0.0045
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0045
6500	Phospholipase A2	PLA2G1B	0.0045
2300	Lysozyme	E	0.0045
3633	Lysozyme	R	0.0045
5597	Lysozyme	17	0.0045
54	Prothrombin	F2	0.0045
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0044
6044	Serum paraoxonase/lactonase 3	PON3	0.0044
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0044
1178	Adenosine A2a receptor	ADORA2A	0.0044
106	Cannabinoid receptor 2	CNR2	0.0044
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0043
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0043
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0043
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0043
517	Alcohol dehydrogenase 1C	ADH1C	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
6102	Arylamine N-acetyltransferase 2	NAT2	0.0042
6221	Steroid hormone receptor ERR1	ESRRA	0.0042
3639	Thymidine phosphorylase	deoA	0.0042
3936	Thymidine phosphorylase	TYMP	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
295	Carbonic anhydrase 1	CA1	0.0041
572	Integrin alpha-L	ITGAL	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0041
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0039
4041	Microsomal glutathione S-transferase 2	MGST2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
357	Carbonic anhydrase 2	CA2	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
1864	RET proto-oncogene	RET	0.0038
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0038
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0038
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0037
2112	Toll-like receptor 9	TLR9	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
340	Apoptotic protease-activating factor 1	APAF1	0.0035
856	Vitamin D3 receptor	VDR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
939	50S ribosomal protein L3	rplC	0.0035
976	Platelet glycoprotein IX	GP9	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
1714	Mitogen-activated protein kinase 3	MAPK3	0.0034
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0034
3927	Choline transporter-like protein 3	SLC44A3	0.0034
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0034
769	High-affinity choline transporter 1	SLC5A7	0.0034
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0034
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0034
1686	Choline transporter-like protein 1	SLC44A1	0.0034
3926	Choline transporter-like protein 2	SLC44A2	0.0034
861	Choline kinase alpha	CHKA	0.0034
700	Choline dehydrogenase, mitochondrial	CHDH	0.0034
3925	Choline transporter-like protein 4	SLC44A4	0.0034
576	Choline O-acetyltransferase	CHAT	0.0034
3922	Phospholipase D2	PLD2	0.0034
1928	Leukotriene C4 synthase	LTC4S	0.0034
3924	Phospholipase D1	PLD1	0.0034
4034	Glutaredoxin-1	GLRX	0.0034
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0034
4037	Hypothetical protein	GPX1	0.0034
4297	Hypothetical protein	SP_1951	0.0034
4521	Hypothetical protein	BC_2969	0.0034
4540	Hypothetical protein	TM_1070	0.0034
4555	Hypothetical protein	MT1739	0.0034
4569	Hypothetical protein	mshD	0.0034
4578	Hypothetical protein	PA3270	0.0034
4747	Hypothetical protein	PA3967	0.0034
5177	Hypothetical protein	TM_0096	0.0034
5194	Hypothetical protein	PA1204	0.0034
5240	Hypothetical protein	Rv2991	0.0034
5370	Hypothetical protein	TM_1158	0.0034
5710	Hypothetical protein	Tb927.5.1360	0.0034
907	Glutathione peroxidase 2	GPX2	0.0034
4029	Microsomal glutathione S-transferase 3	MGST3	0.0034
4032	Microsomal glutathione S-transferase 1	MGST1	0.0034
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0034
910	Epididymal secretory glutathione peroxidase	GPX5	0.0034
4040	Glutathione peroxidase 7	GPX7	0.0034
4036	Glutathione peroxidase 6	GPX6	0.0034
903	Glutathione S-transferase A5	GSTA5	0.0034
906	Glutathione peroxidase 1	GPX1	0.0034
900	Glutathione S-transferase A4	GSTA4	0.0034
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0034
911	Glutathione peroxidase 3	GPX3	0.0034
4035	Glutathione S-transferase Mu 5	GSTM5	0.0034
4033	S-formylglutathione hydrolase	ESD	0.0034
4038	Glutathione peroxidase 4	GPX4	0.0034
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0034
4042	Glutathione transferase omega-2	GSTO2	0.0034
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0034
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0033
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
5682	Ribonuclease pancreatic	RNASE1	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
828	Phenylalanine-4-hydroxylase	PAH	0.0032
3109	Phenylalanine-4-hydroxylase	phhA	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
3086	Plasmepsin-2	Not Available	0.0032
88	Retinoic acid receptor RXR-beta	RXRB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0031
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
4031	Glutathione S-transferase A1	GSTA1	0.0031
898	Glutathione S-transferase A3	GSTA3	0.0031
897	Glutathione S-transferase kappa 1	GSTK1	0.0031
174	Sigma 1-type opioid receptor	SIGMAR1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
909	Maleylacetoacetate isomerase	GSTZ1	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
905	Glutathione transferase omega-1	GSTO1	0.003
899	Glutathione S-transferase Mu 3	GSTM3	0.003
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
292	Activin receptor type-1	ACVR1	0.0029
849	Activated CDC42 kinase 1	TNK2	0.0028
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
2165	Glutathione S-transferase Mu 2	GSTM2	0.0027
4311	tRNA	TRDMT1	0.0027
4325	tRNA	trmD	0.0027
4328	tRNA	trmD	0.0027
4217	Telomerase reverse transcriptase	TERT	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
207	Glutathione synthetase	GSS	0.0026
5269	Glutathione synthetase	gshB	0.0026
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
901	Glutathione S-transferase Mu 4	GSTM4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0025
2021	Thrombomodulin	THBD	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
162	Retinoic acid receptor gamma-1	RARG	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
714	Glutathione reductase, mitochondrial	GSR	0.0022
5798	Mitogen-activated protein kinase 11	MAPK11	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2320	Thymidine kinase, cytosolic	TK1	0.0022
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
558	Solute carrier family 12 member 1	SLC12A1	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
760	Fibroblast growth factor 1	FGF1	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
1792	Tissue-type plasminogen activator	PLAT	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6755	Poliovirus receptor	PVR	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
3957	Adenosine deaminase	ADA	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
1039	Histone deacetylase 9	HDAC9	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
2207	Rhodopsin	RHO	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3937	Fatty-acid amide hydrolase	FAAH	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
563	Thyroid peroxidase	TPO	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00541 - Vincristine

Targets

Enzymes

Transporters

Predictions