DT-Web: DB01115

Identification

Name

Nifedipine

Accession Number

DB01115 (APRD00590)

Type

small molecule

Description

Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug's vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

346.3346

Groups

approved

Monoisotopic Weight

346.116486318

Pharmacology

Indication

For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

Mechanism of action

Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in an overall decrease in blood pressure.

Absorption

Rapidly and fully absorbed following oral administration.

Protein binding

92-98%

Biotransformation

Hepatic metabolism via cytochrome P450 system. Predominantly metabolized by CYP3A4, but also by CYP1A2 and CYP2A6 isozymes.

Route of elimination

Nifedipine is extensively metabolized to highly water-soluble, inactive metabolites accounting for 60 to 80% of the dose excreted in the urine. The remainder is excreted in the feces in metabolized form, most likely as a result of biliary excretion.

Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amobarbital	The barbiturate, amobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Aprobarbital	The barbiturate, aprobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Butabarbital	The barbiturate, butabarbital, decreases the effect of the calcium channel blocker, nifedipine.
Butalbital	The barbiturate, butalbital, decreases the effect of the calcium channel blocker, nifedipine.
Butethal	The barbiturate, butethal, decreases the effect of the calcium channel blocker, nifedipine.
Cimetidine	Cimetidine may increase the effect of the calcium channel blocker, nifedipine.
Cisapride	Cisapride may increase the effect and toxicity of nifedipine.
Cyclosporine	Increased risk of gingivitis
Dihydroquinidine barbiturate	Decreased quinidine effect, increased nifedipine effect
Etravirine	Nifedipine, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to monitor nifedipine therapy for reduced effectiveness.
Ginseng	Ginseng increases the effect and toxicity of nifedipine
Heptabarbital	The barbiturate, heptabarbital, decreases the effect of the calcium channel blocker, nifedipine.
Hexobarbital	The barbiturate, hexobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Imatinib	Imatinib increases the effect and toxicity of nifedipine
Melatonin	Melatonin can possibly decrease the effect of nifedipine
Methohexital	The barbiturate, methohexital, decreases the effect of the calcium channel blocker, nifedipine.
Methylphenobarbital	The barbiturate, methylphenobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Pentobarbital	The barbiturate, pentobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Phenobarbital	The barbiturate, phenobarbital, may decrease the effect of the calcium channel blocker, nifedipine.
Primidone	The barbiturate, primidone, decreases the effect of the calcium channel blocker, nifedipine.
Quinidine	Decreased quinidine effect, increased nifedipine effect
Quinidine barbiturate	Decreased quinidine effect, increased nifedipine effect
Quinupristin	Synercid increases the effect of ziprasidone
Rifampin	Rifampin decreases the effect of the calcium channel blocker, nifedipine.
Secobarbital	The barbiturate, secobarbital, decreases the effect of the calcium channel blocker, nifedipine.
St. John's Wort	St. John's Wort decreases the effect of nifedipine
Tacrine	The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Nifedipine, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Nifedipine is initiated, discontinued or if the dose is changed.
Tacrolimus	The calcium channel blocker, Nifedipine, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Nifedipine therapy is initiated, discontinued or altered.
Talbutal	The barbiturate, talbutal, decreases the effect of the calcium channel blocker, nifedipine.
Telithromycin	Telithromycin may reduce clearance of Nifedipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nifedipine if Telithromycin is initiated, discontinued or dose changed.
Thiopental	The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nifedipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nifedipine if Thiopental is initiated, discontinued or dose changed.
Tipranavir	Tipranavir may decrease the metabolism and clearance of the calcium channel blocker, Nifedipine. Monitor for changes in Nifedipine therapeutic and adverse effects if Tipranavir is initiated, discontinued or dose changed.
Tizanidine	Nifedipine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of nifedipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nifedipine if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Take with low fat meal.
Grapefruit down-regulates post-translational expression of CYP3A4, the major metabolizing enzyme of nifedipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of nifedipine and may cause toxicity. Avoid grapefruit products while on this medication.
Avoid alcohol.
Avoid natural licorice.

Voltage-dependent L-type calcium channel subunit alpha-1C
Name	Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name	CACNA1C
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Morel N, Buryi V, Feron O, Gomez JP, Christen MO, Godfraind T: The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits. Br J Pharmacol. 1998 Nov;125(5):1005-12. - Pubmed Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score	0.6376
Voltage-dependent calcium channel subunit alpha-2/delta-1
Name	Voltage-dependent calcium channel subunit alpha-2/delta-1
Gene Name	CACNA2D1
Pharmacological action	yes
Actions	inhibitor
References	Li GR, Deng XL, Sun H, Chung SS, Tse HF, Lau CP: Ion channels in mesenchymal stem cells from rat bone marrow. Stem Cells. 2006 Jun;24(6):1519-28. Epub 2006 Feb 16. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5463
Voltage-dependent L-type calcium channel subunit beta-2
Name	Voltage-dependent L-type calcium channel subunit beta-2
Gene Name	CACNB2
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score	0.5215
Voltage-dependent L-type calcium channel subunit alpha-1D
Name	Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name	CACNA1D
Pharmacological action	yes
Actions	inhibitor
References	Bell DC, Butcher AJ, Berrow NS, Page KM, Brust PF, Nesterova A, Stauderman KA, Seabrook GR, Nurnberg B, Dolphin AC: Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. J Neurophysiol. 2001 Feb;85(2):816-27. - Pubmed Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. Epub 2008 Nov 24. - Pubmed
DTHybrid score	0.5229
Voltage-dependent L-type calcium channel subunit alpha-1S
Name	Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name	CACNA1S
Pharmacological action	yes
Actions	inhibitor
References	Peterson BZ, Catterall WA: Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug;70(2):667-75. Epub 2006 May 4. - Pubmed
DTHybrid score	0.5581
Calmodulin
Name	Calmodulin
Gene Name	CALM1
Pharmacological action	unknown
Actions	inhibitor
References	Lamers JM, Cysouw KJ, Verdouw PD: Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase. Biochem Pharmacol. 1985 Nov 1;34(21):3837-43. - Pubmed
DTHybrid score	0.5162
Potassium voltage-gated channel subfamily A member 1
Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	KCNA1
Pharmacological action	unknown
Actions	inhibitor
References	Bett GC, Rasmusson RL: Modification of K+ channel-drug interactions by ancillary subunits. J Physiol. 2008 Feb 15;586(4):929-50. Epub 2007 Dec 20. - Pubmed
DTHybrid score	0.2126
Voltage-dependent T-type calcium channel subunit alpha-1H
Name	Voltage-dependent T-type calcium channel subunit alpha-1H
Gene Name	CACNA1H
Pharmacological action	unknown
Actions	inhibitor
References	Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed
DTHybrid score	0.3471

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Bayer. Adalat® CC (nifedipine) extended-release tablets prescribing information. West Haven, CT; 2004 Oct. - Foti RS, Rock DA, Wienkers LC, Wahlstrom JL: Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation. Drug Metab Dispos. 2010 Jun;38(6):981-7. Epub 2010 Mar 4. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Lee SJ, Bell DA, Coulter SJ, Ghanayem B, Goldstein JA: Recombinant CYP3A417 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A417 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. J Pharmacol Exp Ther. 2005 Apr;313(1):302-9. Epub 2005 Jan 5. - Pubmed Pelkonen O, Maenpaa J, Taavitsainen P, Rautio A, Raunio H: Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica. 1998 Dec;28(12):1203-53. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. - Pubmed
DTHybrid score	1.2338
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7066
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5633
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Bayer. Adalat® CC (nifedipine) extended-release tablets prescribing information. West Haven, CT; 2004 Oct. - Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8103
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Bayer. Adalat® CC (nifedipine) extended-release tablets prescribing information. West Haven, CT; 2004 Oct. -
DTHybrid score	0.5182
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6264
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8535
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.565
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4576
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5758
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8186

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inducer
References	Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. - Pubmed
DTHybrid score	0.197
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. Eur J Pharm Sci. 2001 Feb;12(4):505-13. - Pubmed Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. - Pubmed Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. - Pubmed Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score	0.7904
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inducer
References	Payen L, Sparfel L, Courtois A, Vernhet L, Guillouzo A, Fardel O: The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds. Cell Biol Toxicol. 2002;18(4):221-33. - Pubmed
DTHybrid score	0.3267

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.575
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.2398
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.2123
587	Serum albumin	ALB	0.2024
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.1828
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.1705
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.159
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1512
862	Multidrug resistance-associated protein 1	ABCC1	0.1494
20	Prostaglandin G/H synthase 1	PTGS1	0.1457
492	Histamine H1 receptor	HRH1	0.1416
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1287
6106	Cytochrome P450 2C18	CYP2C18	0.1259
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.1209
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.1135
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.1135
831	D(2) dopamine receptor	DRD2	0.1116
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.1107
776	Bile salt export pump	ABCB11	0.1102
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.1101
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1097
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.1096
1898	Cytochrome P450 1B1	CYP1B1	0.1096
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.108
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.1077
2164	Multidrug resistance-associated protein 4	ABCC4	0.1073
556	Alpha-1A adrenergic receptor	ADRA1A	0.1061
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.1057
705	Glutamate receptor 1	GRIA1	0.1045
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.1031
824	Sodium-dependent serotonin transporter	SLC6A4	0.1028
537	ATP synthase delta chain, mitochondrial	ATP5D	0.1008
6145	Solute carrier family 22 member 1	SLC22A1	0.0997
1729	Solute carrier family 22 member 6	SLC22A6	0.0991
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0963
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0943
482	Glycine receptor subunit alpha-1	GLRA1	0.0942
3811	Cytochrome P450 19A1	CYP19A1	0.0939
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0927
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0897
6144	Solute carrier family 22 member 2	SLC22A2	0.0855
737	Mineralocorticoid receptor	NR3C2	0.0818
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0817
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0807
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0804
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0798
6048	Troponin C, skeletal muscle	TNNC2	0.0788
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0777
290	Prostaglandin G/H synthase 2	PTGS2	0.0771
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0768
118	Organic cation/carnitine transporter 2	SLC22A5	0.0754
318	Alpha-2A adrenergic receptor	ADRA2A	0.0744
4604	Liver carboxylesterase 1	CES1	0.0726
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0707
136	Estrogen receptor	ESR1	0.0703
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0696
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0691
632	Alpha-1B adrenergic receptor	ADRA1B	0.068
193	Beta-1 adrenergic receptor	ADRB1	0.0665
847	Mu-type opioid receptor	OPRM1	0.0654
766	Beta-2 adrenergic receptor	ADRB2	0.063
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0629
6148	Multidrug resistance-associated protein 7	ABCC10	0.0625
468	Cytochrome P450 4A11	CYP4A11	0.0608
6143	Solute carrier family 22 member 7	SLC22A7	0.0596
6220	Aryl hydrocarbon receptor	AHR	0.0595
6142	Solute carrier family 22 member 8	SLC22A8	0.0595
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0594
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0593
3923	Cholinesterase	BCHE	0.0585
789	Alpha-1D adrenergic receptor	ADRA1D	0.0584
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0579
6147	Solute carrier family 22 member 3	SLC22A3	0.0577
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0569
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0568
23	D(1A) dopamine receptor	DRD1	0.0566
871	Glucocorticoid receptor	NR3C1	0.0556
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0555
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0555
817	DNA topoisomerase 2-alpha	TOP2A	0.0553
6031	Cytochrome P450 3A43	CYP3A43	0.0553
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0542
467	Delta-type opioid receptor	OPRD1	0.0536
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0531
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.052
713	Sodium-dependent dopamine transporter	SLC6A3	0.0508
696	Kappa-type opioid receptor	OPRK1	0.0508
260	Cytochrome P450 51	ERG11	0.0495
761	Cytochrome P450 51	ERG11	0.0495
3163	Cytochrome P450 51	cyp51	0.0495
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0495
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0494
3941	Amine oxidase [flavin-containing] A	MAOA	0.0473
833	Organic cation/carnitine transporter 1	SLC22A4	0.0468
731	HIV-1 protease	HIV-1 protease	0.0467
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0448
629	Alpha-2B adrenergic receptor	ADRA2B	0.0448
378	Alpha-2C adrenergic receptor	ADRA2C	0.0434
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0432
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.043
6137	Multidrug resistance-associated protein 6	ABCC6	0.0429
638	D(3) dopamine receptor	DRD3	0.0424
6141	Sodium/bile acid cotransporter	SLC10A1	0.0418
16	Adenosine A1 receptor	ADORA1	0.0417
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0416
6136	Multidrug resistance-associated protein 5	ABCC5	0.0415
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.041
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0396
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0391
477	DNA topoisomerase 4 subunit A	parC	0.0386
886	DNA topoisomerase 4 subunit A	parC	0.0386
6226	DNA topoisomerase 4 subunit A	parC	0.0386
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0381
404	DNA gyrase subunit A	gyrA	0.038
6224	DNA gyrase subunit A	gyrA	0.038
1089	Cartilage oligomeric matrix protein	COMP	0.0378
1108	Calpastatin	CAST	0.0378
3939	Amine oxidase [flavin-containing] B	MAOB	0.0367
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0364
1507	Cytochrome c	CYCS	0.0364
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0358
295	Carbonic anhydrase 1	CA1	0.0353
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.035
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.035
722	Troponin I, cardiac muscle	TNNI3	0.0347
70	Type-1 angiotensin II receptor	AGTR1	0.0342
1024	Solute carrier family 22 member 11	SLC22A11	0.034
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0337
6014	Cytochrome P450 2A13	CYP2A13	0.0336
614	Progesterone receptor	PGR	0.033
6182	Cytochrome P450 2J2	CYP2J2	0.0329
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0327
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0322
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0322
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0318
777	Tumor necrosis factor	TNF	0.031
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.031
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0309
751	Potassium channel subfamily K member 6	KCNK6	0.0307
3947	Xanthine dehydrogenase/oxidase	XDH	0.0302
122	P2Y purinoceptor 12	P2RY12	0.0302
24	Thymidylate synthase	TMP1	0.0295
359	Thymidylate synthase	TYMS	0.0295
2626	Thymidylate synthase	thyA	0.0295
2729	Thymidylate synthase	thyA	0.0295
5352	Thymidylate synthase	THYA	0.0295
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0295
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0294
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.029
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0288
172	Potassium channel subfamily K member 1	KCNK1	0.028
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0277
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0277
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0277
504	Mast/stem cell growth factor receptor	KIT	0.027
1757	Myeloperoxidase	MPO	0.0268
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0266
844	Epidermal growth factor receptor	EGFR	0.0265
891	Dihydropteroate synthase	folP	0.026
5359	Dihydropteroate synthase	folP	0.026
7175	Dihydropteroate synthase	sulI	0.026
36	Insulin receptor	INSR	0.0258
146	Androgen receptor	AR	0.0258
811	Translocator protein	TSPO	0.0255
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0253
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0249
6102	Arylamine N-acetyltransferase 2	NAT2	0.0249
4120	NADPH--cytochrome P450 reductase	POR	0.0248
1010	Cytochrome P450 51A1	CYP51A1	0.0243
233	Potassium channel subfamily K member 2	KCNK2	0.0242
161	Tubulin beta chain	TUBB	0.0241
312	Tubulin beta chain	TUB2	0.0241
380	Cytochrome P450 17A1	CYP17A1	0.0237
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0236
432	D(4) dopamine receptor	DRD4	0.0235
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0233
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0233
869	Estrogen receptor beta	ESR2	0.0227
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0226
2132	Protein S100-B	S100B	0.0222
94	5-hydroxytryptamine 4 receptor	HTR4	0.0222
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0213
738	Monocarboxylate transporter 1	SLC16A1	0.0212
6020	Aldehyde oxidase	AOX1	0.021
1178	Adenosine A2a receptor	ADORA2A	0.021
756	Sex hormone-binding globulin	SHBG	0.021
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.021
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0208
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0208
29	Tubulin beta-1 chain	TUBB1	0.0208
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0205
26	Vascular endothelial growth factor receptor 3	FLT4	0.0203
716	5-hydroxytryptamine 7 receptor	HTR7	0.0202
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0202
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0202
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0201
407	Vascular endothelial growth factor receptor 2	KDR	0.0199
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0199
232	Corticosteroid-binding globulin	SERPINA6	0.0198
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0197
908	Glutathione S-transferase theta-1	GSTT1	0.0196
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0196
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0196
1192	Sulfotransferase 1A1	SULT1A1	0.0196
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0196
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0195
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0195
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0195
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0194
3932	Glutathione S-transferase A2	GSTA2	0.0194
275	Arachidonate 5-lipoxygenase	ALOX5	0.0193
32	Vascular endothelial growth factor receptor 1	FLT1	0.0193
6085	Fatty acid-binding protein, intestinal	FABP2	0.0193
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0192
904	Glutathione S-transferase P	GSTP1	0.019
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.019
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0188
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0186
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0185
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0185
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0185
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0185
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0185
818	50S ribosomal protein L10	rplJ	0.0184
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.018
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0179
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0179
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0174
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0171
124	Histamine H2 receptor	HRH2	0.0168
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0168
131	Synaptic vesicular amine transporter	SLC18A2	0.0167
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0167
2449	Tubulin alpha-3 chain	TUBA1A	0.0166
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0163
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0161
952	Dipeptidyl peptidase 4	DPP4	0.016
4237	50S ribosomal protein L22	rplV	0.016
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0159
1656	CYP2B protein	CYP2B	0.0158
4122	Histone deacetylase 2	HDAC2	0.0158
6146	High affinity copper uptake protein 1	SLC31A1	0.0157
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0156
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
365	Dihydrofolate reductase	DHFR	0.0153
2381	Dihydrofolate reductase	DFR1	0.0153
2833	Dihydrofolate reductase	Not Available	0.0153
2931	Dihydrofolate reductase	folA	0.0153
3544	Dihydrofolate reductase	folA	0.0153
3682	Dihydrofolate reductase	folA	0.0153
6642	Dihydrofolate reductase	folA	0.0153
6756	Dihydrofolate reductase	dfrA	0.0153
2539	Tubulin alpha-1 chain	TUBA4A	0.0153
4238	50S ribosomal protein L4	rplD	0.0153
5578	50S ribosomal protein L4	rplD	0.0153
6173	50S ribosomal protein L4	rplD	0.0153
6219	50S ribosomal protein L4	rplD	0.0153
474	Acetylcholinesterase	ACHE	0.0153
427	Substance-P receptor	TACR1	0.0152
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0151
373	Transthyretin	TTR	0.0151
84	Nuclear receptor 0B1	NR0B1	0.015
1517	Beta-3 adrenergic receptor	ADRB3	0.0149
921	Glutamate receptor 2	GRIA2	0.0148
3810	Catechol O-methyltransferase	COMT	0.0147
174	Sigma 1-type opioid receptor	SIGMAR1	0.0147
571	Melatonin receptor type 1A	MTNR1A	0.0146
362	Melatonin receptor type 1B	MTNR1B	0.0146
2392	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0146
3032	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0146
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0146
2499	Tubulin beta-2C chain	TUBB2C	0.0144
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0143
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0143
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0143
1629	Transcription factor AP-1	JUN	0.0142
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0142
1618	High affinity nerve growth factor receptor	NTRK1	0.0142
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.014
273	Apoptosis regulator Bcl-2	BCL2	0.0139
33	Cystine/glutamate transporter	SLC7A11	0.0139
163	D(1B) dopamine receptor	DRD5	0.0139
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0137
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0135
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0135
1650	Heme carrier protein 1	SLC46A1	0.0134
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0133
165	FL cytokine receptor	FLT3	0.0133
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
592	Carbonic anhydrase 4	CA4	0.0131
4116	Dihydropteroate synthetase	Not Available	0.0131
4203	Histamine N-methyltransferase	HNMT	0.013
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.013
2298	Cytochrome P450-cam	camC	0.0129
251	Alcohol dehydrogenase 1A	ADH1A	0.0129
790	DNA polymerase subunit alpha B	POLA2	0.0129
322	Vasopressin V2 receptor	AVPR2	0.0128
284	DNA-directed RNA polymerase beta chain	rpoB	0.0127
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0127
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0127
4192	DNA topoisomerase 2-beta	TOP2B	0.0126
2112	Toll-like receptor 9	TLR9	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0126
469	Annexin A1	ANXA1	0.0126
1050	Bile salt sulfotransferase	SULT2A1	0.0125
444	Alcohol dehydrogenase 1B	ADH1B	0.0125
117	Sterol O-acyltransferase 1	SOAT1	0.0125
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0124
3809	Estrogen-related receptor gamma	ESRRG	0.0124
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0124
2314	Triosephosphate isomerase	TPI	0.0123
3417	Triosephosphate isomerase	tpiA	0.0123
3443	Triosephosphate isomerase	tpiA	0.0123
6346	Triosephosphate isomerase	TPI1	0.0123
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0122
1852	Microtubule-associated protein 2	MAP2	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
517	Alcohol dehydrogenase 1C	ADH1C	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.012
6859	Protein S100-A4	S100A4	0.0119
2808	Chloramphenicol acetyltransferase 3	cat3	0.0119
814	Ryanodine receptor 1	RYR1	0.0118
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0118
6126	Carbonic anhydrase 7	CA7	0.0117
823	Fibroblast growth factor receptor 2	FGFR2	0.0117
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0117
2795	Methionine aminopeptidase 2	METAP2	0.0117
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0117
1262	Corticotropin-lipotropin	POMC	0.0117
896	Glutathione S-transferase Mu 1	GSTM1	0.0116
48	Pyridoxal kinase	PDXK	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
6165	Copper-transporting ATPase 1	ATP7A	0.0115
6163	Copper-transporting ATPase 2	ATP7B	0.0115
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0114
88	Retinoic acid receptor RXR-beta	RXRB	0.0114
2230	Catalase	CAT	0.0114
3249	Catalase	katA	0.0114
3625	Catalase	katA	0.0114
4539	Catalase	katA	0.0114
4941	Catalase	katB	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
768	FK506-binding protein 1A	FKBP1A	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
357	Carbonic anhydrase 2	CA2	0.0112
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0112
293	Gamma-glutamyl hydrolase	GGH	0.0111
6149	Solute carrier family 22 member 10	SLC22A10	0.011
890	Niemann-Pick C1-like protein 1	NPC1L1	0.011
7	Nitric oxide synthase, inducible	NOS2	0.011
68	Cannabinoid receptor 1	CNR1	0.0109
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
518	Peroxidase/catalase T	katG	0.0109
2443	Azurin	azu	0.0108
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0108
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0108
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0107
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0107
239	Coagulation factor X	F10	0.0107
6043	Putative G-protein coupled receptor 44	GPR44	0.0106
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0106
723	Cytosolic phospholipase A2	PLA2G4A	0.0106
6766	O-GlcNAcase BT_4395	BT_4395	0.0105
4773	Deoxycytidine kinase	DCK	0.0105
319	Opioid receptor, sigma 1	OPRS1	0.0105
6138	Multidrug resistance protein 3	ABCB4	0.0105
5682	Ribonuclease pancreatic	RNASE1	0.0104
5923	Microtubule-associated protein tau	MAPT	0.0104
5924	Microtubule-associated protein 4	MAP4	0.0104
1353	DNA topoisomerase 1	TOP1	0.0104
3552	DNA topoisomerase 1	topA	0.0104
563	Thyroid peroxidase	TPO	0.0103
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0103
5626	Nucleoside diphosphate kinase B	NME2	0.0102
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0102
780	Retinoic acid receptor RXR-gamma	RXRG	0.0102
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
4311	tRNA	TRDMT1	0.01
4325	tRNA	trmD	0.01
4328	tRNA	trmD	0.01
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.01
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0099
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
1760	Aminopeptidase N	ANPEP	0.0097
6843	Aminopeptidase N	pepN	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
976	Platelet glycoprotein IX	GP9	0.0095
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0095
1275	Estrogen sulfotransferase	SULT1E1	0.0095
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0094
54	Prothrombin	F2	0.0093
6167	Organic solute transporter subunit beta	OSTB	0.0093
6166	Organic solute transporter subunit alpha	OSTA	0.0093
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0092
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0092
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0092
6044	Serum paraoxonase/lactonase 3	PON3	0.0091
1630	Integrin beta-2	ITGB2	0.0091
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
461	Glycine receptor subunit alpha-3	GLRA3	0.009
153	Dopamine beta-hydroxylase	DBH	0.0089
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0089
6174	50S ribosomal protein L32	rpmF	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
162	Retinoic acid receptor gamma-1	RARG	0.0088
3830	Calreticulin	CALR	0.0087
820	Glycine receptor subunit alpha-2	GLRA2	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0087
5934	Cytochrome P450 26A1	CYP26A1	0.0087
6432	Transporter	snf	0.0086
299	Folate receptor beta	FOLR2	0.0086
718	Folate receptor gamma	FOLR3	0.0086
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0086
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0086
1714	Mitogen-activated protein kinase 3	MAPK3	0.0086
4226	Uridine phosphorylase 2	UPP2	0.0085
106	Cannabinoid receptor 2	CNR2	0.0085
5294	Nucleoside diphosphate kinase A	NME1	0.0083
6035	Nuclear receptor ROR-beta	RORB	0.0082
6034	Hydroxyindole O-methyltransferase	ASMT	0.0082
6036	Eosinophil peroxidase	EPX	0.0082
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0082
569	Retinal dehydrogenase 2	ALDH1A2	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
719	Retinoic acid receptor responder protein 1	RARRES1	0.008
770	Retinoic acid-induced protein 3	GPRC5A	0.008
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0079
173	Toll-like receptor 7	TLR7	0.0079
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0078
4225	Uridine phosphorylase 1	UPP1	0.0078
6131	Carbonic anhydrase 14	CA14	0.0078
856	Vitamin D3 receptor	VDR	0.0077
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
611	Retinal dehydrogenase 1	ALDH1A1	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
3937	Fatty-acid amide hydrolase	FAAH	0.0076
5300	Antigen peptide transporter 1	TAP1	0.0075
581	Cytochrome P450 2R1	CYP2R1	0.0075
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0075
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0074
4103	Proteasome subunit beta type 2	PSMB2	0.0074
4102	Proteasome subunit beta type 5	PSMB5	0.0074
4101	Proteasome subunit beta type 1	PSMB1	0.0074
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0074
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0074
1541	Metalloproteinase	mmp20	0.0074
3639	Thymidine phosphorylase	deoA	0.0074
3936	Thymidine phosphorylase	TYMP	0.0074
413	Amidophosphoribosyltransferase	PPAT	0.0073
2515	Amidophosphoribosyltransferase	purF	0.0073
3714	Amidophosphoribosyltransferase	purF	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
6122	Carbonic anhydrase 3	CA3	0.0072
1483	Membrane copper amine oxidase	AOC3	0.0072
765	Indoleamine 2,3-dioxygenase	IDO1	0.0072
183	Vascular endothelial growth factor A	VEGFA	0.0072
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0071
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0071
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0071
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0071
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0071
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.007
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.007
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.007
3587	Gastrotropin	FABP6	0.007
49	Endothelin B receptor	EDNRB	0.0069
3601	Dihydropteroate synthase 1	folP1	0.0069
3807	Dihydropteroate synthase 1	folP1	0.0069
3808	Dihydropteroate synthase 2	folP2	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
634	Squalene monooxygenase	SQLE	0.0068
7196	Squalene monooxygenase	ERG1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
1636	Trace amine-associated receptor 1	TAAR1	0.0067
702	UMP-CMP kinase	CMPK1	0.0067
1196	Complement decay-accelerating factor	CD55	0.0067
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0067
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0066
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0066
3856	Fibroblast growth factor receptor 3	FGFR3	0.0066
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0065
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
1176	Mitogen-activated protein kinase 1	MAPK1	0.0065
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0065
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0064
1569	G1/S-specific cyclin-D1	CCND1	0.0064
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0064
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0064
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0064
3957	Adenosine deaminase	ADA	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
2616	Ganglioside GM2 activator	GM2A	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
3270	Elongation factor G	fusA	0.0062
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0061
1992	Vitamin D-binding protein	GC	0.0061
1374	Natriuretic peptides B	NPPB	0.0061
1827	Gap junction alpha-1 protein	GJA1	0.0061
1908	Vascular cell adhesion protein 1	VCAM1	0.0061
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.006
936	Ephrin type-A receptor 2	EPHA2	0.006
3007	Carbonic anhydrase 12	CA12	0.006
4205	Carbonic anhydrase 9	CA9	0.006
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.006
6218	Pannexin-1	PANX1	0.006
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0059
291	Nitric-oxide synthase, endothelial	NOS3	0.0059
489	Monocarboxylate transporter 2	SLC16A7	0.0059
2232	Interleukin-5	IL5	0.0059
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0059
1593	Mucin-2	MUC2	0.0059
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0059
6134	Sodium channel subunit beta-3	SCN3B	0.0058
6132	Sodium channel subunit beta-1	SCN1B	0.0058
6135	Sodium channel subunit beta-4	SCN4B	0.0058
6129	Carbonic anhydrase-related protein 11	CA11	0.0058
6133	Sodium channel subunit beta-2	SCN2B	0.0058
6127	Carbonic anhydrase-related protein	CA8	0.0058
6128	Carbonic anhydrase-related protein 10	CA10	0.0058
572	Integrin alpha-L	ITGAL	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
714	Glutathione reductase, mitochondrial	GSR	0.0058
164	Histamine H4 receptor	HRH4	0.0057
400	Coagulation factor IX	F9	0.0057
5461	Coagulation factor IX	F9	0.0057
3913	Glutamic acid decarboxylase	GAD65	0.0057
558	Solute carrier family 12 member 1	SLC12A1	0.0056
267	Plasminogen activator inhibitor 1	SERPINE1	0.0055
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0055
6506	Stathmin-4	STMN4	0.0055
5787	Angiopoietin-1 receptor	TEK	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
268	Adenosine A2b receptor	ADORA2B	0.0054
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0053
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0053
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0053
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0053
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0053
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0053
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0053
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0053
2417	Chloramphenicol acetyltransferase	cat	0.0053
3278	Chloramphenicol acetyltransferase	cat	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0052
604	Vitamin K-dependent protein Z	PROZ	0.0052
2810	Dr hemagglutinin structural subunit	draA	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0052
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0052
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0052
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
6168	Solute carrier family 22 member 16	SLC22A16	0.0052
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
1313	Lactoylglutathione lyase	GLO1	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0051
6130	Carbonic anhydrase 13	CA13	0.0051
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.005
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.005
6221	Steroid hormone receptor ERR1	ESRRA	0.0049
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0049
1123	Eosinophil cationic protein	RNASE3	0.0049
3404	Exotoxin A	eta	0.0049
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
422	Vitamin K-dependent protein C	PROC	0.0048
1245	Vitamin K-dependent protein S	PROS1	0.0048
3904	Alanine aminotransferase 2	GPT2	0.0048
735	Alanine aminotransferase 1	GPT	0.0048
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0047
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0047
484	Tyrosine-protein kinase ABL2	ABL2	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
1039	Histone deacetylase 9	HDAC9	0.0046
2236	Casein kinase II subunit alpha	CSNK2A1	0.0046
4217	Telomerase reverse transcriptase	TERT	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6211	Tubulin epsilon chain	TUBE1	0.0045
6210	Tubulin delta chain	TUBD1	0.0045
6212	Tubulin gamma-1 chain	TUBG1	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
6042	Prostaglandin reductase 2	PTGR2	0.0045
2599	Tyrosine-protein kinase HCK	HCK	0.0044
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0044
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0044
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0044
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0044
1268	Neuropeptide S receptor	NPSR1	0.0044
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0044
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0044
4210	Toll-like receptor 4	TLR4	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0043
2207	Rhodopsin	RHO	0.0043
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0042
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0042
5818	Folate receptor alpha	FOLR1	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0042
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1864	RET proto-oncogene	RET	0.0041
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.004
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.004
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
65	Matrix metalloproteinase-9	Not Available	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
730	Retinoic acid receptor alpha	RARA	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6073	Potassium channel subfamily K member 9	KCNK9	0.004
6072	Potassium channel subfamily K member 3	KCNK3	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
798	Osteocalcin	BGLAP	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
2391	Ferrochelatase	hemH	0.0038
6502	Ferrochelatase	DKFZp686P18130	0.0038
1591	Ferrochelatase, mitochondrial	FECH	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
76	Nitric-oxide synthase, brain	NOS1	0.0037
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0036
6837	Serine/threonine-protein kinase 17B	STK17B	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
2320	Thymidine kinase, cytosolic	TK1	0.0035
369	Coagulation factor VII	F7	0.0035
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
758	Thyroid hormone receptor alpha	THRA	0.0034
6755	Poliovirus receptor	PVR	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0034
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0033
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0033
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0033
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0033
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0033
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0033
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0033
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0033
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0033
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0033
6559	Cytochrome c oxidase subunit 2	ctaC	0.0033
6669	Cytochrome c oxidase subunit 2	ctaC	0.0033
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0033
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0033
6558	Cytochrome c oxidase subunit 1	ctaD	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
5798	Mitogen-activated protein kinase 11	MAPK11	0.0031
4041	Microsomal glutathione S-transferase 2	MGST2	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2540	Choloylglycine hydrolase	cbh	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
6459	Glycodelin	PAEP	0.0028
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
6501	Fatty acid-binding protein, liver	FABP1	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0027
2297	Genome polyprotein	Not Available	0.0027
2322	Genome polyprotein	Not Available	0.0027
2694	Genome polyprotein	Not Available	0.0027
2719	Genome polyprotein	Not Available	0.0027
2860	Genome polyprotein	Not Available	0.0027
2928	Genome polyprotein	Not Available	0.0027
3160	Genome polyprotein	Not Available	0.0027
3260	Genome polyprotein	Not Available	0.0027
4783	Genome polyprotein	Not Available	0.0027
5726	Genome polyprotein	Not Available	0.0027
5779	Genome polyprotein	Not Available	0.0027
5867	Genome polyprotein	Not Available	0.0027
6253	Genome polyprotein	Not Available	0.0027
6301	Genome polyprotein	Not Available	0.0027
6380	Genome polyprotein	Not Available	0.0027
6381	Genome polyprotein	Not Available	0.0027
6437	Genome polyprotein	Not Available	0.0027
6520	Genome polyprotein	Not Available	0.0027
6521	Genome polyprotein	Not Available	0.0027
6652	Genome polyprotein	Not Available	0.0027
6734	Genome polyprotein	Not Available	0.0027
6735	Genome polyprotein	Not Available	0.0027
6736	Genome polyprotein	Not Available	0.0027
6737	Genome polyprotein	Not Available	0.0027
6738	Genome polyprotein	Not Available	0.0027
6739	Genome polyprotein	Not Available	0.0027
6744	Genome polyprotein	Not Available	0.0027
6748	Genome polyprotein	Not Available	0.0027
6894	Genome polyprotein	Not Available	0.0027
6898	Genome polyprotein	Not Available	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2408	Tyrosine-protein kinase SYK	SYK	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0026
6316	ADP-ribosylation factor 1	ARF1	0.0026
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0026
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
6228	Nuclear receptor coactivator 1	NCOA1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
4034	Glutaredoxin-1	GLRX	0.0024
1928	Leukotriene C4 synthase	LTC4S	0.0024
907	Glutathione peroxidase 2	GPX2	0.0024
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0024
4037	Hypothetical protein	GPX1	0.0024
4297	Hypothetical protein	SP_1951	0.0024
4521	Hypothetical protein	BC_2969	0.0024
4540	Hypothetical protein	TM_1070	0.0024
4555	Hypothetical protein	MT1739	0.0024
4569	Hypothetical protein	mshD	0.0024
4578	Hypothetical protein	PA3270	0.0024
4747	Hypothetical protein	PA3967	0.0024
5177	Hypothetical protein	TM_0096	0.0024
5194	Hypothetical protein	PA1204	0.0024
5240	Hypothetical protein	Rv2991	0.0024
5370	Hypothetical protein	TM_1158	0.0024
5710	Hypothetical protein	Tb927.5.1360	0.0024
4029	Microsomal glutathione S-transferase 3	MGST3	0.0024
4032	Microsomal glutathione S-transferase 1	MGST1	0.0024
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0024
4040	Glutathione peroxidase 7	GPX7	0.0024
910	Epididymal secretory glutathione peroxidase	GPX5	0.0024
903	Glutathione S-transferase A5	GSTA5	0.0024
4038	Glutathione peroxidase 4	GPX4	0.0024
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0024
906	Glutathione peroxidase 1	GPX1	0.0024
4033	S-formylglutathione hydrolase	ESD	0.0024
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0024
4035	Glutathione S-transferase Mu 5	GSTM5	0.0024
4036	Glutathione peroxidase 6	GPX6	0.0024
900	Glutathione S-transferase A4	GSTA4	0.0024
911	Glutathione peroxidase 3	GPX3	0.0024
4042	Glutathione transferase omega-2	GSTO2	0.0024
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
4031	Glutathione S-transferase A1	GSTA1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6500	Phospholipase A2	PLA2G1B	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
760	Fibroblast growth factor 1	FGF1	0.0024
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0024
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
822	Aldose reductase	AKR1B1	0.0023
3221	Cytochrome c4	cc4	0.0023
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0022
394	Calcineurin subunit B isoform 1	PPP3R1	0.0022
6742	Recoverin	RCVRN	0.0022
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0022
2528	Fatty acid metabolism regulator protein	fadR	0.0022
6740	Fatty acid metabolism regulator protein	fadR	0.0022
6753	Apolipoprotein M	APOM	0.0022
6747	Chalcone/stilbene synthase family protein	MT1417	0.0022
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0022
6743	Non-fluorescent flavoprotein	luxF	0.0022
6751	Gag polyprotein	gag	0.0022
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0022
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0022
6749	Polyprotein	Not Available	0.0022
898	Glutathione S-transferase A3	GSTA3	0.0022
897	Glutathione S-transferase kappa 1	GSTK1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
909	Maleylacetoacetate isomerase	GSTZ1	0.0021
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
2091	Endoplasmin	HSP90B1	0.0021
905	Glutathione transferase omega-1	GSTO1	0.0021
899	Glutathione S-transferase Mu 3	GSTM3	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
1970	Protein kinase C alpha type	PRKCA	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
5961	Insulin	INS	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
2165	Glutathione S-transferase Mu 2	GSTM2	0.0019
6527	Lymphocyte antigen 96	LY96	0.0019
207	Glutathione synthetase	GSS	0.0019
5269	Glutathione synthetase	gshB	0.0019
2021	Thrombomodulin	THBD	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
901	Glutathione S-transferase Mu 4	GSTM4	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
6750	ADP-ribosylation factor 6	ARF6	0.0018
6524	Protein tonB	tonB	0.0018
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6151	Monocarboxylate transporter 10	SLC16A10	0.0017
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0016
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0016
1243	Cathepsin D	CTSD	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6677	Myelin P2 protein	PMP2	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
864	Gag-Pol polyprotein	gag-pol	0.0014
2237	Gag-Pol polyprotein	gag-pol	0.0014
2326	Gag-Pol polyprotein	gag-pol	0.0014
2451	Gag-Pol polyprotein	gag-pol	0.0014
2901	Gag-Pol polyprotein	gag-pol	0.0014
3165	Gag-Pol polyprotein	gag-pol	0.0014
3722	Gag-Pol polyprotein	gag-pol	0.0014
6306	Gag-Pol polyprotein	gag-pol	0.0014
6624	Gag-Pol polyprotein	gag-pol	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
1792	Tissue-type plasminogen activator	PLAT	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2427	Ferrichrome-iron receptor	fhuA	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
85	Growth hormone receptor	GHR	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
292	Activin receptor type-1	ACVR1	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0011
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2802	Endoglucanase G	celCCG	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
345	Plasma retinol-binding protein	RBP4	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01115 - Nifedipine

Targets

Enzymes

Transporters

Predictions