DT-Web

DB00418 - Secobarbital


Identification
Name Secobarbital
Accession Number DB00418 (APRD00497)
Type small molecule
Description Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal(R) and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 238.2829
Groups approved
Monoisotopic Weight 238.131742452
Pharmacology
Indication For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
Mechanism of action Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and the metabolic products are excreted in the urine and, less commonly, in the feces.
Toxicity Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline The barbiturate, secobarbital, decreases the effect of aminophylline.
Bendamustine CYP1A2 metabolism may result in increased levels of active metabolites, decreases levels of bendamustine.
Betamethasone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, betamethasone.
Clomifene The enzyme inducer, secobarbital, decreases the effect of the hormone agent, clomifene.
Conjugated Estrogens The enzyme inducer, secobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Cyclosporine The barbiturate, secobarbital, increases the effect of cyclosporine.
Dexamethasone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Diethylstilbestrol The enzyme inducer, secobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Doxycycline The anticonvulsant , secobarbital, decreases the effect of doxycycline.
Estradiol The enzyme inducer, secobarbital, decreases the effect of the hormone agent, estradiol.
Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
Felodipine The barbiturate, secobarbital, decreases the effect of felodipine.
Fludrocortisone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Folic Acid Folic acid decreases the effect of anticonvulsant, secobarbital.
Gefitinib The CYP3A4 inducer, secobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Griseofulvin The barbiturate, secobarbital, decreases the effect of griseofulvin.
Hydrocortisone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Levonorgestrel Phenobarbital decreases the effect of levonorgestrel
Medroxyprogesterone The enzyme inducer, secobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Megestrol The enzyme inducer, secobarbital, decreases the effect of the hormone agent, megestrol.
Methadone The barbiturate, secobarbital, decreases the effect of methadone.
Metronidazole The barbiturate, secobarbital, decreases the effect of metronidazole.
Nifedipine The barbiturate, secobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Norethindrone This product may cause a slight decrease of contraceptive effect
Oxtriphylline The barbiturate, secobarbital, decreases the effect of oxtriphylline.
Prednisolone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisolone.
Prednisone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisone.
Quinidine The anticonvulsant, secobarbital, decreases the effect of quinidine.
Theophylline The barbiturate, secobarbital, decreases the effect of theophylline.
Tretinoin The strong CYP2C8 inducer, Secobarbital, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Secobarbital is initiated, discontinued or dose changed.
Triamcinolone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, triamcinolone.
Trimipramine The barbiturate, Secobarbital, may increase the metabolism and clearance of Trimipramine. Monitor for changes in the therapeutics and adverse effects of Trimipramine if Secobarbital is initiated, discontinued or dose changed. Dose adjustments of Trimipramine may be required.
Triprolidine The CNS depressants, Triprolidine and Secobarbital, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Verapamil Secobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Secobarbital is initiated, discontinued or dose changed.
Warfarin Secobarbital may decrease the serum concentration of warfarin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of warfarin if secobarbital is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
  • Peters JA, Kirkness EF, Callachan H, Lambert JJ, Turner AJ: Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids. Br J Pharmacol. 1988 Aug;94(4):1257-69. - Pubmed
  • Miller LG, Deutsch SI, Greenblatt DJ, Paul SM, Shader RI: Acute barbiturate administration increases benzodiazepine receptor binding in vivo. Psychopharmacology (Berl). 1988;96(3):385-90. - Pubmed
  • Kirkness EF, Turner AJ: The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum. Biochem J. 1986 Jan 1;233(1):265-70. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8526
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7961
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7841
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions potentiator
References
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7417
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7932
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions potentiator
References
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
DTHybrid score 0.742
Neuronal acetylcholine receptor subunit alpha-4
Name Neuronal acetylcholine receptor subunit alpha-4
Gene Name CHRNA4
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.6961
Neuronal acetylcholine receptor subunit alpha-7
Name Neuronal acetylcholine receptor subunit alpha-7
Gene Name CHRNA7
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.6963
Glutamate receptor 2
Name Glutamate receptor 2
Gene Name GRIA2
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 1.3104
Glutamate receptor, ionotropic kainate 2
Name Glutamate receptor, ionotropic kainate 2
Gene Name GRIK2
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.8404

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Visser LE, van Schaik RH, Jan Danser AH, Hofman A, Witteman JC, van Duijn CM, Uitterlinden AG, Pols HA, Stricker BH: The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. Pharmacogenet Genomics. 2007 Jul;17(7):473-9. - Pubmed
DTHybrid score 0.415
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inducer
References
  • -
  • Visser LE, van Schaik RH, Jan Danser AH, Hofman A, Witteman JC, van Duijn CM, Uitterlinden AG, Pols HA, Stricker BH: The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. Pharmacogenet Genomics. 2007 Jul;17(7):473-9. - Pubmed
DTHybrid score 0.2961
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inducer
References
  • Sakuma T, Ohtake M, Katsurayama Y, Jarukamjorn K, Nemoto N: Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. Drug Metab Dispos. 1999 Mar;27(3):379-84. - Pubmed
DTHybrid score 0.3554

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3563
6016 Cytochrome P450 2C19 CYP2C19 0.2924
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.193
6013 Cytochrome P450 2E1 CYP2E1 0.188
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.1864
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.1843
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1809
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1722
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1713
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1711
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1709
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1707
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1707
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1704
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1702
4119 Cytochrome P450 2D6 CYP2D6 0.1692
6030 Cytochrome P450 2B6 CYP2B6 0.1674
1588 Multidrug resistance protein 1 ABCB1 0.1353
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.1258
4118 Cytochrome P450 3A5 CYP3A5 0.1179
811 Translocator protein TSPO 0.1106
5718 Cytochrome P450 2A6 CYP2A6 0.1084
20 Prostaglandin G/H synthase 1 PTGS1 0.1069
6107 Cytochrome P450 3A7 CYP3A7 0.0985
6024 Cytochrome P450 1A1 CYP1A1 0.084
587 Serum albumin ALB 0.0649
6106 Cytochrome P450 2C18 CYP2C18 0.0611
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0577
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.051
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0423
3937 Fatty-acid amide hydrolase FAAH 0.0389
290 Prostaglandin G/H synthase 2 PTGS2 0.0384
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0372
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0362
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0349
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0347
1898 Cytochrome P450 1B1 CYP1B1 0.0338
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0325
862 Multidrug resistance-associated protein 1 ABCC1 0.0314
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0298
502 5-hydroxytryptamine 2A receptor HTR2A 0.0291
1729 Solute carrier family 22 member 6 SLC22A6 0.0271
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0269
468 Cytochrome P450 4A11 CYP4A11 0.0259
36 Insulin receptor INSR 0.0258
172 Potassium channel subfamily K member 1 KCNK1 0.0253
831 D(2) dopamine receptor DRD2 0.0252
492 Histamine H1 receptor HRH1 0.025
776 Bile salt export pump ABCB11 0.0247
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0246
6145 Solute carrier family 22 member 1 SLC22A1 0.0246
3811 Cytochrome P450 19A1 CYP19A1 0.0237
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.023
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.023
6144 Solute carrier family 22 member 2 SLC22A2 0.0227
824 Sodium-dependent serotonin transporter SLC6A4 0.0211
482 Glycine receptor subunit alpha-1 GLRA1 0.0208
3941 Amine oxidase [flavin-containing] A MAOA 0.0207
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0203
318 Alpha-2A adrenergic receptor ADRA2A 0.0202
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0192
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0189
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0189
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0189
136 Estrogen receptor ESR1 0.0179
23 D(1A) dopamine receptor DRD1 0.0178
556 Alpha-1A adrenergic receptor ADRA1A 0.0177
2164 Multidrug resistance-associated protein 4 ABCC4 0.0174
6031 Cytochrome P450 3A43 CYP3A43 0.0173
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0162
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0161
118 Organic cation/carnitine transporter 2 SLC22A5 0.0161
6102 Arylamine N-acetyltransferase 2 NAT2 0.016
923 Glutamate receptor 3 GRIA3 0.0159
3939 Amine oxidase [flavin-containing] B MAOB 0.0156
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0156
705 Glutamate receptor 1 GRIA1 0.0155
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0155
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0149
6142 Solute carrier family 22 member 8 SLC22A8 0.0148
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0148
537 ATP synthase delta chain, mitochondrial ATP5D 0.0147
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0143
6143 Solute carrier family 22 member 7 SLC22A7 0.014
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.014
590 5-hydroxytryptamine 2C receptor HTR2C 0.0138
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0138
341 5-hydroxytryptamine 3 receptor HTR3A 0.0136
891 Dihydropteroate synthase folP 0.0133
5359 Dihydropteroate synthase folP 0.0133
7175 Dihydropteroate synthase sulI 0.0133
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0129
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0127
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
817 DNA topoisomerase 2-alpha TOP2A 0.0127
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0125
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0124
465 Calmodulin CALM1 0.0124
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0121
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0118
70 Type-1 angiotensin II receptor AGTR1 0.0118
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0117
6147 Solute carrier family 22 member 3 SLC22A3 0.0117
122 P2Y purinoceptor 12 P2RY12 0.0116
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0115
885 5-hydroxytryptamine 1B receptor HTR1B 0.0114
6014 Cytochrome P450 2A13 CYP2A13 0.011
629 Alpha-2B adrenergic receptor ADRA2B 0.011
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0109
833 Organic cation/carnitine transporter 1 SLC22A4 0.0109
713 Sodium-dependent dopamine transporter SLC6A3 0.0109
3923 Cholinesterase BCHE 0.0108
632 Alpha-1B adrenergic receptor ADRA1B 0.0105
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0104
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0104
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0104
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0103
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0102
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0101
1024 Solute carrier family 22 member 11 SLC22A11 0.0099
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0099
3426 Glutamine synthetase glnA 0.0099
3987 Glutamine synthetase GLUL 0.0099
731 HIV-1 protease HIV-1 protease 0.0097
725 5-hydroxytryptamine 1D receptor HTR1D 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0096
696 Kappa-type opioid receptor OPRK1 0.0096
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0095
766 Beta-2 adrenergic receptor ADRB2 0.0094
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0093
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0093
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0091
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0091
320 5-hydroxytryptamine 1A receptor HTR1A 0.009
467 Delta-type opioid receptor OPRD1 0.009
847 Mu-type opioid receptor OPRM1 0.009
16 Adenosine A1 receptor ADORA1 0.0089
4116 Dihydropteroate synthetase Not Available 0.0087
474 Acetylcholinesterase ACHE 0.0085
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0084
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0084
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0083
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0082
193 Beta-1 adrenergic receptor ADRB1 0.0081
260 Cytochrome P450 51 ERG11 0.0081
761 Cytochrome P450 51 ERG11 0.0081
3163 Cytochrome P450 51 cyp51 0.0081
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0081
146 Androgen receptor AR 0.0081
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.008
6182 Cytochrome P450 2J2 CYP2J2 0.0079
1757 Myeloperoxidase MPO 0.0078
571 Melatonin receptor type 1A MTNR1A 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
777 Tumor necrosis factor TNF 0.0077
1178 Adenosine A2a receptor ADORA2A 0.0076
820 Glycine receptor subunit alpha-2 GLRA2 0.0076
789 Alpha-1D adrenergic receptor ADRA1D 0.0076
365 Dihydrofolate reductase DHFR 0.0075
2381 Dihydrofolate reductase DFR1 0.0075
2833 Dihydrofolate reductase Not Available 0.0075
2931 Dihydrofolate reductase folA 0.0075
3544 Dihydrofolate reductase folA 0.0075
3682 Dihydrofolate reductase folA 0.0075
6642 Dihydrofolate reductase folA 0.0075
6756 Dihydrofolate reductase dfrA 0.0075
638 D(3) dopamine receptor DRD3 0.0074
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0074
871 Glucocorticoid receptor NR3C1 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0072
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0071
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0071
6020 Aldehyde oxidase AOX1 0.0071
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
6220 Aryl hydrocarbon receptor AHR 0.0071
6136 Multidrug resistance-associated protein 5 ABCC5 0.007
94 5-hydroxytryptamine 4 receptor HTR4 0.007
504 Mast/stem cell growth factor receptor KIT 0.007
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.007
6141 Sodium/bile acid cotransporter SLC10A1 0.0068
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0067
869 Estrogen receptor beta ESR2 0.0066
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0065
592 Carbonic anhydrase 4 CA4 0.0065
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0065
380 Cytochrome P450 17A1 CYP17A1 0.0063
133 Dihydropterate synthase sulI 0.0063
3810 Catechol O-methyltransferase COMT 0.0061
275 Arachidonate 5-lipoxygenase ALOX5 0.006
1541 Metalloproteinase mmp20 0.006
6148 Multidrug resistance-associated protein 7 ABCC10 0.0059
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0059
407 Vascular endothelial growth factor receptor 2 KDR 0.0058
5880 Thrombopoietin receptor MPL 0.0058
378 Alpha-2C adrenergic receptor ADRA2C 0.0058
844 Epidermal growth factor receptor EGFR 0.0058
427 Substance-P receptor TACR1 0.0057
6085 Fatty acid-binding protein, intestinal FABP2 0.0057
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0056
4122 Histone deacetylase 2 HDAC2 0.0056
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0056
2981 Phospholipase A2, membrane associated PLA2G2A 0.0056
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0056
273 Apoptosis regulator Bcl-2 BCL2 0.0055
88 Retinoic acid receptor RXR-beta RXRB 0.0054
1648 Elastin ELN 0.0054
6137 Multidrug resistance-associated protein 6 ABCC6 0.0054
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0054
432 D(4) dopamine receptor DRD4 0.0053
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0053
24 Thymidylate synthase TMP1 0.0053
359 Thymidylate synthase TYMS 0.0053
2626 Thymidylate synthase thyA 0.0053
2729 Thymidylate synthase thyA 0.0053
5352 Thymidylate synthase THYA 0.0053
4604 Liver carboxylesterase 1 CES1 0.0052
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0052
436 5-hydroxytryptamine 2B receptor HTR2B 0.0052
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0051
1010 Cytochrome P450 51A1 CYP51A1 0.0051
26 Vascular endothelial growth factor receptor 3 FLT4 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
738 Monocarboxylate transporter 1 SLC16A1 0.0049
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0049
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0049
228 Beta platelet-derived growth factor receptor PDGFRB 0.0048
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0048
1275 Estrogen sulfotransferase SULT1E1 0.0048
357 Carbonic anhydrase 2 CA2 0.0047
32 Vascular endothelial growth factor receptor 1 FLT1 0.0047
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
461 Glycine receptor subunit alpha-3 GLRA3 0.0045
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0045
295 Carbonic anhydrase 1 CA1 0.0045
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0044
49 Endothelin B receptor EDNRB 0.0044
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
511 5-hydroxytryptamine 1F receptor HTR1F 0.0043
373 Transthyretin TTR 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
4120 NADPH--cytochrome P450 reductase POR 0.0042
6044 Serum paraoxonase/lactonase 3 PON3 0.0041
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0041
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0041
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
29 Tubulin beta-1 chain TUBB1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
4203 Histamine N-methyltransferase HNMT 0.0041
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0041
3947 Xanthine dehydrogenase/oxidase XDH 0.004
518 Peroxidase/catalase T katG 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0039
33 Cystine/glutamate transporter SLC7A11 0.0038
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0038
162 Retinoic acid receptor gamma-1 RARG 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0038
614 Progesterone receptor PGR 0.0038
1629 Transcription factor AP-1 JUN 0.0037
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
130 Prostacyclin synthase PTGIS 0.0037
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0036
780 Retinoic acid receptor RXR-gamma RXRG 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
737 Mineralocorticoid receptor NR3C2 0.0036
208 DNA-directed RNA polymerase beta' chain rpoC 0.0036
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0035
124 Histamine H2 receptor HRH2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0034
823 Fibroblast growth factor receptor 2 FGFR2 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0032
730 Retinoic acid receptor alpha RARA 0.0032
3957 Adenosine deaminase ADA 0.0032
1656 CYP2B protein CYP2B 0.0032
1050 Bile salt sulfotransferase SULT2A1 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0032
251 Alcohol dehydrogenase 1A ADH1A 0.0032
6146 High affinity copper uptake protein 1 SLC31A1 0.0032
1192 Sulfotransferase 1A1 SULT1A1 0.0031
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0031
716 5-hydroxytryptamine 7 receptor HTR7 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
818 50S ribosomal protein L10 rplJ 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
183 Vascular endothelial growth factor A VEGFA 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
173 Toll-like receptor 7 TLR7 0.003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0029
54 Prothrombin F2 0.0029
1618 High affinity nerve growth factor receptor NTRK1 0.0029
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0029
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0029
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0028
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0028
444 Alcohol dehydrogenase 1B ADH1B 0.0028
4311 tRNA TRDMT1 0.0028
4325 tRNA trmD 0.0028
4328 tRNA trmD 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
284 DNA-directed RNA polymerase beta chain rpoB 0.0027
5773 DNA-directed RNA polymerase beta chain rpoB 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
952 Dipeptidyl peptidase 4 DPP4 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0026
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
239 Coagulation factor X F10 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
6174 50S ribosomal protein L32 rpmF 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
1196 Complement decay-accelerating factor CD55 0.0025
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0025
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0025
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0025
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0025
153 Dopamine beta-hydroxylase DBH 0.0025
3809 Estrogen-related receptor gamma ESRRG 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
1517 Beta-3 adrenergic receptor ADRB3 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
976 Platelet glycoprotein IX GP9 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0024
4102 Proteasome subunit beta type 5 PSMB5 0.0024
4101 Proteasome subunit beta type 1 PSMB1 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0024
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0024
517 Alcohol dehydrogenase 1C ADH1C 0.0024
6070 Nischarin NISCH 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0023
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0023
814 Ryanodine receptor 1 RYR1 0.0023
922 Glutamate receptor 4 GRIA4 0.0023
528 5-hydroxytryptamine 1E receptor HTR1E 0.0022
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0022
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0022
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
4027 Glutamate receptor delta-1 subunit GRID1 0.0022
4018 Glutamate receptor delta-2 subunit GRID2 0.0022
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0022
2808 Chloramphenicol acetyltransferase 3 cat3 0.0022
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0022
1912 Excitatory amino acid transporter 1 SLC1A3 0.0022
664 Glutamate decarboxylase 2 GAD2 0.0022
3890 Glutamate decarboxylase 2 GAD2 0.0022
4016 Excitatory amino acid transporter 5 SLC1A7 0.0022
4019 Excitatory amino acid transporter 4 SLC1A6 0.0022
1047 Excitatory amino acid transporter 2 SLC1A2 0.0022
4026 Aspartyl aminopeptidase DNPEP 0.0022
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0022
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0022
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0022
925 Metabotropic glutamate receptor 4 GRM4 0.0022
926 Metabotropic glutamate receptor 7 GRM7 0.0022
927 Metabotropic glutamate receptor 8 GRM8 0.0022
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0022
4020 Glutamyl aminopeptidase ENPEP 0.0022
4017 5-oxoprolinase OPLAH 0.0022
3086 Plasmepsin-2 Not Available 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0022
904 Glutathione S-transferase P GSTP1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4225 Uridine phosphorylase 1 UPP1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
563 Thyroid peroxidase TPO 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
165 FL cytokine receptor FLT3 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.002
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
2207 Rhodopsin RHO 0.002
268 Adenosine A2b receptor ADORA2B 0.002
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.002
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.002
1268 Neuropeptide S receptor NPSR1 0.002
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.002
3808 Dihydropteroate synthase 2 folP2 0.002
3601 Dihydropteroate synthase 1 folP1 0.002
3807 Dihydropteroate synthase 1 folP1 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
625 Glutamate carboxypeptidase 2 FOLH1 0.002
908 Glutathione S-transferase theta-1 GSTT1 0.002
2417 Chloramphenicol acetyltransferase cat 0.002
3278 Chloramphenicol acetyltransferase cat 0.002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
469 Annexin A1 ANXA1 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
1820 Beta-nerve growth factor NGF 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0019
5 Glutaminase liver isoform, mitochondrial GLS2 0.0019
917 Glutaminase kidney isoform, mitochondrial GLS 0.0019
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0019
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0019
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0019
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0019
5261 Phosphoribosylformylglycinamidine synthase purL 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
665 Phosphoserine aminotransferase PSAT1 0.0019
4652 Phosphoserine aminotransferase serC 0.0019
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0019
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0019
420 Glutamate decarboxylase 1 GAD1 0.0019
3900 Glutamate decarboxylase 1 GAD1 0.0019
164 Histamine H4 receptor HRH4 0.0018
161 Tubulin beta chain TUBB 0.0018
312 Tubulin beta chain TUB2 0.0018
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
6073 Potassium channel subfamily K member 9 KCNK9 0.0018
6072 Potassium channel subfamily K member 3 KCNK3 0.0018
916 Metabotropic glutamate receptor 1 GRM1 0.0018
1992 Vitamin D-binding protein GC 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0017
4192 DNA topoisomerase 2-beta TOP2B 0.0017
1671 Excitatory amino acid transporter 3 SLC1A1 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0017
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0017
828 Phenylalanine-4-hydroxylase PAH 0.0017
3109 Phenylalanine-4-hydroxylase phhA 0.0017
3877 Growth-inhibiting protein 18 GIG18 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0017
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0017
426 Aspartate aminotransferase, mitochondrial GOT2 0.0017
1630 Integrin beta-2 ITGB2 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
1830 5'-nucleotidase NT5E 0.0016
763 Tyrosine aminotransferase TAT 0.0016
5493 Tyrosine aminotransferase Not Available 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
5934 Cytochrome P450 26A1 CYP26A1 0.0016
5787 Angiopoietin-1 receptor TEK 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0016
1243 Cathepsin D CTSD 0.0016
4217 Telomerase reverse transcriptase TERT 0.0016
6151 Monocarboxylate transporter 10 SLC16A10 0.0016
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0016
751 Potassium channel subfamily K member 6 KCNK6 0.0016
936 Ephrin type-A receptor 2 EPHA2 0.0016
3830 Calreticulin CALR 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0016
758 Thyroid hormone receptor alpha THRA 0.0015
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0015
6043 Putative G-protein coupled receptor 44 GPR44 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0015
6036 Eosinophil peroxidase EPX 0.0015
6432 Transporter snf 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
1374 Natriuretic peptides B NPPB 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
1827 Gap junction alpha-1 protein GJA1 0.0014
1908 Vascular cell adhesion protein 1 VCAM1 0.0014
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0014
2539 Tubulin alpha-1 chain TUBA4A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0014
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0014
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
2021 Thrombomodulin THBD 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0013
856 Vitamin D3 receptor VDR 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
3932 Glutathione S-transferase A2 GSTA2 0.0013
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
489 Monocarboxylate transporter 2 SLC16A7 0.0013
572 Integrin alpha-L ITGAL 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
2320 Thymidine kinase, cytosolic TK1 0.0012
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
7 Nitric oxide synthase, inducible NOS2 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6218 Pannexin-1 PANX1 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
106 Cannabinoid receptor 2 CNR2 0.0011
1864 RET proto-oncogene RET 0.0011
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0011
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0011
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0011
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
1483 Membrane copper amine oxidase AOC3 0.001
68 Cannabinoid receptor 1 CNR1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
1341 Histamine H3 receptor HRH3 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
6677 Myelin P2 protein PMP2 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4773 Deoxycytidine kinase DCK 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0007
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0007
822 Aldose reductase AKR1B1 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
3221 Cytochrome c4 cc4 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
1507 Cytochrome c CYCS 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
798 Osteocalcin BGLAP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4916 Cyanoglobin glbN 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4943 Cytochrome c6 petJ 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4984 Neuroglobin NGB 0.0004
4909 CooA protein cooA 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4961 Hemophore HasA hasA 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4910 Cytoglobin CYGB 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4972 P450cin cinA 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4952 Catalase/peroxidase katA 0.0004
1313 Lactoylglutathione lyase GLO1 0.0003
4920 Peroxidase/catalase katG 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0001
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