DT-Web: DB00783

Identification

Name

Estradiol

Accession Number

DB00783 (APRD00311)

Type

small molecule

Description

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

272.382

Groups

approved

Monoisotopic Weight

272.177630012

Pharmacology

Indication

For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Mechanism of action

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Absorption

43%

Protein binding

>95%

Biotransformation

Exogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450.

Route of elimination

Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates.

Toxicity

Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amobarbital	The enzyme inducer, amobarbital, decreases the effect of the hormone agent, estradiol.
Aprobarbital	The enzyme inducer, aprobarbital, decreases the effect of the hormone agent, estradiol.
Butabarbital	The enzyme inducer, butabarbital, decreases the effect of the hormone agent, estradiol.
Butalbital	The enzyme inducer, butalbital, decreases the effect of the hormone agent, estradiol.
Butethal	The enzyme inducer, butethal, decreases the effect of the hormone agent, estradiol.
Ethotoin	The enzyme inducer, ethotoin, decreases the effect of the hormone agent, estradiol.
Fosphenytoin	The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estradiol.
Griseofulvin	The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, estradiol.
Heptabarbital	The enzyme inducer, heptabarbital, decreases the effect of the hormone agent, estradiol.
Hexobarbital	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, estradiol.
Mephenytoin	The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, estradiol.
Methohexital	The enzyme inducer, methohexital, decreases the effect of the hormone agent, estradiol.
Methylphenobarbital	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, estradiol.
Pentobarbital	The enzyme inducer, pentobarbital, decreases the effect of the hormone agent, estradiol.
Phenobarbital	The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estradiol.
Phenytoin	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estradiol.
Prednisolone	The estrogenic agent, estradiol, may increase the effect of the corticosteroid, prednisolone.
Prednisone	The estrogenic agent, estradiol, may increase the effect of corticosteroid, prednisone.
Primidone	The enzyme inducer, primidone, decreases the effect of the hormone agent, estradiol.
Raloxifene	Association not recommended
Secobarbital	The enzyme inducer, secobarbital, decreases the effect of the hormone agent, estradiol.
Talbutal	The enzyme inducer, talbutal, decreases the effect of the hormone agent, estradiol.
Tipranavir	Estradiol may increase the adverse dermatological effects (i.e. skin rash) of Tipranavir. Tipranavir may decrease the serum concentration Estradiol. Use an alternate form of contraception or monitor for estrogen deficiency if Estradiol is used for hormone replacement therapy.
Ursodeoxycholic acid	Estrogens decreases the effect of ursodiol

Food Interactions

Take with food to decrease nausea.

Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	yes
Actions	agonist
References	Brama M, Gnessi L, Basciani S, Cerulli N, Politi L, Spera G, Mariani S, Cherubini S, d'Abusco AS, Scandurra R, Migliaccio S: Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):102-8. Epub 2006 Nov 27. - Pubmed Lehnes K, Winder AD, Alfonso C, Kasid N, Simoneaux M, Summe H, Morgan E, Iann MC, Duncan J, Eagan M, Tavaluc R, Evans CH Jr, Russell R, Wang A, Hu F, Stoica A: The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway. Endocrinology. 2007 Mar;148(3):1171-80. Epub 2006 Nov 30. - Pubmed Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.9648
Estrogen receptor beta
Name	Estrogen receptor beta
Gene Name	ESR2
Pharmacological action	yes
Actions	agonist
References	Vijayanathan V, Greenfield NJ, Thomas TJ, Ivanova MM, Tyulmenkov VV, Klinge CM, Gallo MA, Thomas T: Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta. Biochem Cell Biol. 2007 Feb;85(1):1-10. - Pubmed Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed
DTHybrid score	1.053
Nuclear receptor subfamily 1 group I member 2
Name	Nuclear receptor subfamily 1 group I member 2
Gene Name	NR1I2
Pharmacological action	unknown
Actions	Not Available
References	Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Mol Endocrinol. 2007 May;21(5):1028-38. Epub 2007 Feb 27. - Pubmed
DTHybrid score	0.3973

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. - Pubmed
DTHybrid score	1.3025
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. - Pubmed
DTHybrid score	0.7862
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.7196
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5287
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	Hanioka N, Tanabe N, Jinno H, Tanaka-Kagawa T, Nagaoka K, Naito S, Koeda A, Narimatsu S: Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8. Epub 2010 Jul 8. - Pubmed Guillemette C, Belanger A, Lepine J: Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res. 2004;6(6):246-54. Epub 2004 Sep 27. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.3233
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4819
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2985
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7362
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.7444
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8948

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.3861
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.5036
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.2795
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	inhibitor
References	Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A: Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res. 2001 Sep;18(9):1262-9. - Pubmed
DTHybrid score	0.4013
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. - Pubmed Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed Kullak-Ublick, G.A. et al. Organic anion-transporting polypeptide B (OATP- B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120, 525-533 (2001). - Pubmed
DTHybrid score	0.5542
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score	0.2121
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score	0.3396
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. - Pubmed Imai Y, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn J Cancer Res. 2002 Mar;93(3):231-5. - Pubmed
DTHybrid score	0.5665
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A: Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res. 2001 Sep;18(9):1262-9. - Pubmed Kullak-Ublick, G.A. et al. Organic anion-transporting polypeptide B (OATP- B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120, 525-533 (2001). - Pubmed
DTHybrid score	0.6514
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Rao US, Fine RL, Scarborough GA: Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. - Pubmed Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. - Pubmed
DTHybrid score	1.04
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	Not Available
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score	0.5509
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	Not Available
References	Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.4551
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	Not Available
References	Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score	0.2909
Solute carrier organic anion transporter family member 4A1
Name	Solute carrier organic anion transporter family member 4A1
Gene Name	SLCO4A1
Actions	Not Available
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score	0.2566

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions
References	Not Available
DTHybrid score	0.3861
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.5036
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions
References	Not Available
DTHybrid score	0.2795
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions
References	Not Available
DTHybrid score	0.4013
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.5542
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions
References	Not Available
DTHybrid score	0.2121
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.3396
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.5665
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.6514
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	1.04
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.5509
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions
References	Not Available
DTHybrid score	0.4551
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions
References	Not Available
DTHybrid score	0.2909
Solute carrier organic anion transporter family member 4A1
Name	Solute carrier organic anion transporter family member 4A1
Gene Name	SLCO4A1
Actions
References	Not Available
DTHybrid score	0.2566

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.6077
1729	Solute carrier family 22 member 6	SLC22A6	0.4007
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.3904
6030	Cytochrome P450 2B6	CYP2B6	0.3795
862	Multidrug resistance-associated protein 1	ABCC1	0.3076
6013	Cytochrome P450 2E1	CYP2E1	0.2961
6228	Nuclear receptor coactivator 1	NCOA1	0.2811
20	Prostaglandin G/H synthase 1	PTGS1	0.2586
6241	Nuclear receptor coactivator 2	NCOA2	0.2557
776	Bile salt export pump	ABCB11	0.2337
6143	Solute carrier family 22 member 7	SLC22A7	0.2272
2164	Multidrug resistance-associated protein 4	ABCC4	0.22
5718	Cytochrome P450 2A6	CYP2A6	0.2057
3811	Cytochrome P450 19A1	CYP19A1	0.1979
118	Organic cation/carnitine transporter 2	SLC22A5	0.1919
6141	Sodium/bile acid cotransporter	SLC10A1	0.1761
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.174
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1709
290	Prostaglandin G/H synthase 2	PTGS2	0.1621
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1596
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1588
146	Androgen receptor	AR	0.1444
833	Organic cation/carnitine transporter 1	SLC22A4	0.1376
6106	Cytochrome P450 2C18	CYP2C18	0.1313
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1269
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.1236
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.123
614	Progesterone receptor	PGR	0.1201
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1152
758	Thyroid hormone receptor alpha	THRA	0.1109
738	Monocarboxylate transporter 1	SLC16A1	0.1082
492	Histamine H1 receptor	HRH1	0.1042
6136	Multidrug resistance-associated protein 5	ABCC5	0.102
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.1017
6167	Organic solute transporter subunit beta	OSTB	0.0962
6166	Organic solute transporter subunit alpha	OSTA	0.0962
346	Thyroid hormone receptor beta-1	THRB	0.0946
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.09
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.09
871	Glucocorticoid receptor	NR3C1	0.09
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0885
556	Alpha-1A adrenergic receptor	ADRA1A	0.0879
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0876
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0874
373	Transthyretin	TTR	0.0845
594	Thyroxine-binding globulin	SERPINA7	0.0834
824	Sodium-dependent serotonin transporter	SLC6A4	0.0814
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0808
6137	Multidrug resistance-associated protein 6	ABCC6	0.0776
831	D(2) dopamine receptor	DRD2	0.0769
766	Beta-2 adrenergic receptor	ADRB2	0.0762
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0753
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0753
817	DNA topoisomerase 2-alpha	TOP2A	0.075
318	Alpha-2A adrenergic receptor	ADRA2A	0.0727
468	Cytochrome P450 4A11	CYP4A11	0.0716
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0711
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0698
275	Arachidonate 5-lipoxygenase	ALOX5	0.0694
6031	Cytochrome P450 3A43	CYP3A43	0.0679
3587	Gastrotropin	FABP6	0.066
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0656
284	DNA-directed RNA polymerase beta chain	rpoB	0.0654
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0654
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0643
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0632
33	Cystine/glutamate transporter	SLC7A11	0.0623
847	Mu-type opioid receptor	OPRM1	0.0618
70	Type-1 angiotensin II receptor	AGTR1	0.0617
731	HIV-1 protease	HIV-1 protease	0.061
29	Tubulin beta-1 chain	TUBB1	0.0608
273	Apoptosis regulator Bcl-2	BCL2	0.0603
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0602
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0597
3947	Xanthine dehydrogenase/oxidase	XDH	0.0592
1852	Microtubule-associated protein 2	MAP2	0.0586
632	Alpha-1B adrenergic receptor	ADRA1B	0.0586
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0586
193	Beta-1 adrenergic receptor	ADRB1	0.0582
23	D(1A) dopamine receptor	DRD1	0.0574
844	Epidermal growth factor receptor	EGFR	0.0573
3941	Amine oxidase [flavin-containing] A	MAOA	0.0571
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0562
378	Alpha-2C adrenergic receptor	ADRA2C	0.0548
4604	Liver carboxylesterase 1	CES1	0.0546
2183	Fatty acid-binding protein, adipocyte	FABP4	0.054
6560	Nuclear receptor coactivator 5	NCOA5	0.0526
103	Muscarinic acetylcholine receptor M1	CHRM1	0.052
380	Cytochrome P450 17A1	CYP17A1	0.0514
467	Delta-type opioid receptor	OPRD1	0.0512
3923	Cholinesterase	BCHE	0.0508
6149	Solute carrier family 22 member 10	SLC22A10	0.0503
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0502
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0502
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.05
629	Alpha-2B adrenergic receptor	ADRA2B	0.0497
696	Kappa-type opioid receptor	OPRK1	0.0496
713	Sodium-dependent dopamine transporter	SLC6A3	0.0492
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.049
3810	Catechol O-methyltransferase	COMT	0.0489
504	Mast/stem cell growth factor receptor	KIT	0.0482
2853	14 kDa fatty acid-binding protein	Not Available	0.0477
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0471
124	Histamine H2 receptor	HRH2	0.0469
4773	Deoxycytidine kinase	DCK	0.0461
199	Monocarboxylate transporter 8	SLC16A2	0.0457
465	Calmodulin	CALM1	0.0448
5923	Microtubule-associated protein tau	MAPT	0.0442
5924	Microtubule-associated protein 4	MAP4	0.0441
381	Prolactin receptor	PRLR	0.044
789	Alpha-1D adrenergic receptor	ADRA1D	0.0436
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0433
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0425
3437	Eosinophil lysophospholipase	CLC	0.0424
232	Corticosteroid-binding globulin	SERPINA6	0.0423
904	Glutathione S-transferase P	GSTP1	0.0417
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0415
260	Cytochrome P450 51	ERG11	0.0409
761	Cytochrome P450 51	ERG11	0.0409
3163	Cytochrome P450 51	cyp51	0.0409
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0409
6020	Aldehyde oxidase	AOX1	0.0404
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0404
26	Vascular endothelial growth factor receptor 3	FLT4	0.0404
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0401
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0397
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0396
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0394
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0392
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0391
6220	Aryl hydrocarbon receptor	AHR	0.039
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0387
32	Vascular endothelial growth factor receptor 1	FLT1	0.0386
3939	Amine oxidase [flavin-containing] B	MAOB	0.0386
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0384
6014	Cytochrome P450 2A13	CYP2A13	0.0379
672	Prostaglandin F2-alpha receptor	PTGFR	0.0376
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0374
891	Dihydropteroate synthase	folP	0.037
5359	Dihydropteroate synthase	folP	0.037
7175	Dihydropteroate synthase	sulI	0.037
638	D(3) dopamine receptor	DRD3	0.0369
737	Mineralocorticoid receptor	NR3C2	0.0368
2539	Tubulin alpha-1 chain	TUBA4A	0.0368
6151	Monocarboxylate transporter 10	SLC16A10	0.0366
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0364
5626	Nucleoside diphosphate kinase B	NME2	0.0363
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0362
407	Vascular endothelial growth factor receptor 2	KDR	0.0361
563	Thyroid peroxidase	TPO	0.0358
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0357
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0354
4120	NADPH--cytochrome P450 reductase	POR	0.0354
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0351
269	Adrenodoxin, mitochondrial	FDX1	0.0348
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0347
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0345
1757	Myeloperoxidase	MPO	0.0344
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0343
6182	Cytochrome P450 2J2	CYP2J2	0.0337
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0335
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0335
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0334
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0333
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0332
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.033
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0326
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0325
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0325
36	Insulin receptor	INSR	0.0325
161	Tubulin beta chain	TUBB	0.0321
312	Tubulin beta chain	TUB2	0.0321
4203	Histamine N-methyltransferase	HNMT	0.0316
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0311
477	DNA topoisomerase 4 subunit A	parC	0.0309
886	DNA topoisomerase 4 subunit A	parC	0.0309
6226	DNA topoisomerase 4 subunit A	parC	0.0309
404	DNA gyrase subunit A	gyrA	0.0304
6224	DNA gyrase subunit A	gyrA	0.0304
3611	Cytidine deaminase	cdd	0.0302
3707	Cytidine deaminase	cdd	0.0302
4211	Cytidine deaminase	CDA	0.0302
140	30S ribosomal protein S9	rpsI	0.03
6719	30S ribosomal protein S9	rpsI	0.03
6725	30S ribosomal protein S9	rpsI	0.03
1353	DNA topoisomerase 1	TOP1	0.0299
3552	DNA topoisomerase 1	topA	0.0299
469	Annexin A1	ANXA1	0.0297
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0297
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0295
22	30S ribosomal protein S4	rpsD	0.0293
6714	30S ribosomal protein S4	rpsD	0.0293
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0293
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0292
5294	Nucleoside diphosphate kinase A	NME1	0.0291
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0291
2211	Fatty acid-binding protein, heart	FABP3	0.029
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.029
88	Retinoic acid receptor RXR-beta	RXRB	0.0287
122	P2Y purinoceptor 12	P2RY12	0.0284
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0282
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0281
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.028
24	Thymidylate synthase	TMP1	0.028
359	Thymidylate synthase	TYMS	0.028
2626	Thymidylate synthase	thyA	0.028
2729	Thymidylate synthase	thyA	0.028
5352	Thymidylate synthase	THYA	0.028
283	SEC14-like protein 2	SEC14L2	0.0279
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0279
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0279
2021	Thrombomodulin	THBD	0.0278
1517	Beta-3 adrenergic receptor	ADRB3	0.0276
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0273
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0272
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.027
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0268
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0268
908	Glutathione S-transferase theta-1	GSTT1	0.0267
6026	Alcohol dehydrogenase 6	ADH6	0.0266
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0266
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0263
4192	DNA topoisomerase 2-beta	TOP2B	0.0261
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.026
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0259
5880	Thrombopoietin receptor	MPL	0.0259
777	Tumor necrosis factor	TNF	0.0258
3616	Fatty acid-binding protein, epidermal	FABP5	0.0255
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0255
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0255
5431	Lipid binding protein	Not Available	0.0255
5433	UPF0230 protein TM_1468	TM_1468	0.0255
432	D(4) dopamine receptor	DRD4	0.0253
1792	Tissue-type plasminogen activator	PLAT	0.0252
474	Acetylcholinesterase	ACHE	0.0252
811	Translocator protein	TSPO	0.0249
2907	Oxysterols receptor LXR-beta	NR1H2	0.0242
6102	Arylamine N-acetyltransferase 2	NAT2	0.0242
6283	Oxysterols receptor LXR-alpha	NR1H3	0.0242
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0239
2107	Microtubule-associated protein 1A	MAP1A	0.0236
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0235
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0235
3809	Estrogen-related receptor gamma	ESRRG	0.0233
1192	Sulfotransferase 1A1	SULT1A1	0.0231
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.023
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0226
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0225
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0224
952	Dipeptidyl peptidase 4	DPP4	0.0224
7	Nitric oxide synthase, inducible	NOS2	0.0223
558	Solute carrier family 12 member 1	SLC12A1	0.0222
1830	5'-nucleotidase	NT5E	0.0222
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0222
1649	Small inducible cytokine A2	CCL2	0.022
645	Penicillin-binding protein 1A	mrcA	0.022
5805	Penicillin-binding protein 1A	ponA	0.022
6185	Penicillin-binding protein 1A	mrcA	0.022
6799	Penicillin-binding protein 1A	pbpA	0.022
6146	High affinity copper uptake protein 1	SLC31A1	0.022
244	Angiotensin-converting enzyme	ACE	0.0217
6171	Solute carrier family 28 member 3	SLC28A3	0.0216
543	Penicillin-binding protein 1B	mrcB	0.0216
6186	Penicillin-binding protein 1B	ponB	0.0216
6822	Penicillin-binding protein 1b	pbp1b	0.0216
6844	Penicillin-binding protein 1b	pbp1b	0.0216
992	Protein tyrosine kinase 2 beta	PTK2B	0.0216
1010	Cytochrome P450 51A1	CYP51A1	0.0215
183	Vascular endothelial growth factor A	VEGFA	0.0215
527	Prostacyclin receptor	PTGIR	0.0214
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0214
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0214
6677	Myelin P2 protein	PMP2	0.0213
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0213
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0211
887	DNA gyrase subunit B	gyrB	0.0211
4150	DNA gyrase subunit B	gyrB	0.0211
6225	DNA gyrase subunit B	gyrB	0.0211
117	Sterol O-acyltransferase 1	SOAT1	0.0211
6459	Glycodelin	PAEP	0.0208
365	Dihydrofolate reductase	DHFR	0.0208
2381	Dihydrofolate reductase	DFR1	0.0208
2833	Dihydrofolate reductase	Not Available	0.0208
2931	Dihydrofolate reductase	folA	0.0208
3544	Dihydrofolate reductase	folA	0.0208
3682	Dihydrofolate reductase	folA	0.0208
6642	Dihydrofolate reductase	folA	0.0208
6756	Dihydrofolate reductase	dfrA	0.0208
489	Monocarboxylate transporter 2	SLC16A7	0.0207
571	Melatonin receptor type 1A	MTNR1A	0.0206
16	Adenosine A1 receptor	ADORA1	0.0206
362	Melatonin receptor type 1B	MTNR1B	0.0206
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0206
702	UMP-CMP kinase	CMPK1	0.0206
131	Synaptic vesicular amine transporter	SLC18A2	0.0206
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0206
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0204
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0203
1650	Heme carrier protein 1	SLC46A1	0.0201
1178	Adenosine A2a receptor	ADORA2A	0.02
438	Taste receptor type 1 member 2	TAS1R2	0.0197
125	DNA polymerase beta	POLB	0.0197
6070	Nischarin	NISCH	0.0196
4122	Histone deacetylase 2	HDAC2	0.0195
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0195
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0194
2472	Voltage-gated potassium channel	kcsA	0.0193
6366	Voltage-gated potassium channel	kcsA	0.0193
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0193
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0193
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0193
5818	Folate receptor alpha	FOLR1	0.019
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0188
768	FK506-binding protein 1A	FKBP1A	0.0188
293	Gamma-glutamyl hydrolase	GGH	0.0188
633	Penicillin-binding proteins 1A/1B	pbpA	0.0188
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0187
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0186
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0186
3932	Glutathione S-transferase A2	GSTA2	0.0186
338	DNA polymerase	UL30	0.0185
379	DNA polymerase	UL54	0.0185
697	DNA polymerase	ORF28	0.0185
2482	DNA polymerase	43	0.0185
4104	DNA polymerase	BALF5	0.0185
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0185
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0184
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0184
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0183
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0183
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0182
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0181
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0179
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0178
6163	Copper-transporting ATPase 2	ATP7B	0.0178
6165	Copper-transporting ATPase 1	ATP7A	0.0178
4228	Keratin, type II cytoskeletal 7	KRT7	0.0177
3686	Acyl-CoA thioesterase I precursor	tesA	0.0177
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0175
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0175
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0175
319	Opioid receptor, sigma 1	OPRS1	0.0174
163	D(1B) dopamine receptor	DRD5	0.0174
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0172
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0172
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0172
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.017
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.017
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.017
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.017
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
4210	Toll-like receptor 4	TLR4	0.0169
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0168
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0167
818	50S ribosomal protein L10	rplJ	0.0165
164	Histamine H4 receptor	HRH4	0.0165
2449	Tubulin alpha-3 chain	TUBA1A	0.0164
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0164
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0164
6043	Putative G-protein coupled receptor 44	GPR44	0.0163
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0163
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0163
2207	Rhodopsin	RHO	0.0162
1	Peptidoglycan synthetase ftsI	ftsI	0.0162
4155	Peptidoglycan synthetase ftsI	ftsI	0.0162
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0162
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0162
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0162
1618	High affinity nerve growth factor receptor	NTRK1	0.0161
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0161
6218	Pannexin-1	PANX1	0.0161
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0161
6033	High affinity interleukin-8 receptor A	CXCR1	0.016
6010	Thiamine transporter 1	SLC19A2	0.0159
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0159
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0159
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0156
1629	Transcription factor AP-1	JUN	0.0156
716	5-hydroxytryptamine 7 receptor	HTR7	0.0156
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0154
976	Platelet glycoprotein IX	GP9	0.0154
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0154
165	FL cytokine receptor	FLT3	0.0153
3426	Glutamine synthetase	glnA	0.0153
3987	Glutamine synthetase	GLUL	0.0153
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0153
5126	Arginase	rocF	0.0152
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0152
896	Glutathione S-transferase Mu 1	GSTM1	0.0151
3868	Calcineurin subunit B isoform 2	PPP3R2	0.015
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.015
6432	Transporter	snf	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
3856	Fibroblast growth factor receptor 3	FGFR3	0.0149
427	Substance-P receptor	TACR1	0.0149
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0148
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0148
823	Fibroblast growth factor receptor 2	FGFR2	0.0146
6044	Serum paraoxonase/lactonase 3	PON3	0.0145
5353	Glutamate decarboxylase alpha	gadA	0.0145
1630	Integrin beta-2	ITGB2	0.0145
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
1867	Major prion protein	PRNP	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
175	Thiamin pyrophosphokinase 1	TPK1	0.0142
130	Prostacyclin synthase	PTGIS	0.0142
115	Penicillin-binding protein 2	mrdA	0.0141
6069	Penicillin-binding protein 2	mrdA	0.0141
6118	Penicillin-binding protein 2	penA	0.0141
6187	Penicillin-binding protein 2	pbpA	0.0141
6686	Penicillin-binding protein 2	pbp2	0.0141
6939	Penicillin-binding protein 2	mrdA	0.0141
7163	Penicillin-binding protein 2	pbpA	0.0141
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0141
705	Glutamate receptor 1	GRIA1	0.014
4217	Telomerase reverse transcriptase	TERT	0.014
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0139
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0138
4237	50S ribosomal protein L22	rplV	0.0138
814	Ryanodine receptor 1	RYR1	0.0137
357	Carbonic anhydrase 2	CA2	0.0137
1656	CYP2B protein	CYP2B	0.0137
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0137
84	Nuclear receptor 0B1	NR0B1	0.0137
5787	Angiopoietin-1 receptor	TEK	0.0136
936	Ephrin type-A receptor 2	EPHA2	0.0136
3830	Calreticulin	CALR	0.0135
94	5-hydroxytryptamine 4 receptor	HTR4	0.0134
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0134
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0134
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0134
1050	Bile salt sulfotransferase	SULT2A1	0.0133
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0132
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0132
1341	Histamine H3 receptor	HRH3	0.0131
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.013
890	Niemann-Pick C1-like protein 1	NPC1L1	0.013
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0129
4238	50S ribosomal protein L4	rplD	0.0129
5578	50S ribosomal protein L4	rplD	0.0129
6173	50S ribosomal protein L4	rplD	0.0129
6219	50S ribosomal protein L4	rplD	0.0129
295	Carbonic anhydrase 1	CA1	0.0129
6138	Multidrug resistance protein 3	ABCB4	0.0128
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0127
332	Beta-lactamase	blaZ	0.0127
2478	Beta-lactamase	ampC	0.0127
2613	Beta-lactamase	ampC	0.0127
2635	Beta-lactamase	ampC	0.0127
2700	Beta-lactamase	penP	0.0127
5445	Beta-lactamase	blaB	0.0127
6019	Beta-lactamase	SHV-7	0.0127
6701	Beta-lactamase	cphA	0.0127
482	Glycine receptor subunit alpha-1	GLRA1	0.0126
5934	Cytochrome P450 26A1	CYP26A1	0.0126
1714	Mitogen-activated protein kinase 3	MAPK3	0.0126
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0125
6168	Solute carrier family 22 member 16	SLC22A16	0.0125
6034	Hydroxyindole O-methyltransferase	ASMT	0.0125
6035	Nuclear receptor ROR-beta	RORB	0.0125
6036	Eosinophil peroxidase	EPX	0.0125
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0125
6209	30S ribosomal protein S19	rpsS	0.0124
6712	30S ribosomal protein S19	rpsS	0.0124
6726	30S ribosomal protein S19	rpsS	0.0124
6207	30S ribosomal protein S14	rpsN	0.0124
153	Dopamine beta-hydroxylase	DBH	0.0123
723	Cytosolic phospholipase A2	PLA2G4A	0.0123
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
1636	Trace amine-associated receptor 1	TAAR1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0121
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0121
624	Guanidinoacetate N-methyltransferase	GAMT	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0119
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
68	Cannabinoid receptor 1	CNR1	0.0118
603	DNA polymerase alpha catalytic subunit	POLA1	0.0118
828	Phenylalanine-4-hydroxylase	PAH	0.0118
3109	Phenylalanine-4-hydroxylase	phhA	0.0118
1760	Aminopeptidase N	ANPEP	0.0117
6843	Aminopeptidase N	pepN	0.0117
592	Carbonic anhydrase 4	CA4	0.0116
239	Coagulation factor X	F10	0.0116
48	Pyridoxal kinase	PDXK	0.0116
751	Potassium channel subfamily K member 6	KCNK6	0.0115
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0114
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0114
997	Protein kinase C beta type	PRKCB	0.0114
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0113
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0113
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0112
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0112
2300	Lysozyme	E	0.0111
3633	Lysozyme	R	0.0111
5597	Lysozyme	17	0.0111
500	Monocarboxylate transporter 4	SLC16A3	0.0111
1291	cAMP response element-binding protein	CREB1	0.0111
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.011
2320	Thymidine kinase, cytosolic	TK1	0.0109
572	Integrin alpha-L	ITGAL	0.0109
765	Indoleamine 2,3-dioxygenase	IDO1	0.0108
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0108
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0107
172	Potassium channel subfamily K member 1	KCNK1	0.0106
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0105
1970	Protein kinase C alpha type	PRKCA	0.0104
2616	Ganglioside GM2 activator	GM2A	0.0104
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0104
921	Glutamate receptor 2	GRIA2	0.0104
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0103
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0103
1525	Heparin-binding growth factor 2	FGF2	0.0102
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0101
1770	Phospholipase C	PLCL1	0.0101
2841	Phospholipase C	plc	0.0101
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0101
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0101
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0101
2236	Casein kinase II subunit alpha	CSNK2A1	0.01
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0099
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0099
1198	Serum paraoxonase/arylesterase 1	PON1	0.0099
6223	Penicillin-binding protein 1C	pbpC	0.0099
780	Retinoic acid receptor RXR-gamma	RXRG	0.0098
694	Matrix protein 2	M	0.0098
5650	NimA-related protein	DR_0842	0.0098
1864	RET proto-oncogene	RET	0.0098
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0097
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0097
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0097
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
663	Solute carrier family 12 member 4	SLC12A4	0.0096
53	Solute carrier family 12 member 5	SLC12A5	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
49	Endothelin B receptor	EDNRB	0.0096
267	Plasminogen activator inhibitor 1	SERPINE1	0.0095
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0095
4311	tRNA	TRDMT1	0.0095
4325	tRNA	trmD	0.0095
4328	tRNA	trmD	0.0095
1405	Thiopurine S-methyltransferase	TPMT	0.0095
566	Serotransferrin	TF	0.0094
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0094
106	Cannabinoid receptor 2	CNR2	0.0094
1569	G1/S-specific cyclin-D1	CCND1	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0093
1275	Estrogen sulfotransferase	SULT1E1	0.0092
5682	Ribonuclease pancreatic	RNASE1	0.0092
775	Acetyl-CoA carboxylase 2	ACACB	0.0091
65	Matrix metalloproteinase-9	Not Available	0.0091
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
310	Solute carrier family 12 member 2	SLC12A2	0.009
3937	Fatty-acid amide hydrolase	FAAH	0.0089
2249	Aspartate aminotransferase	aspC	0.0089
2671	Aspartate aminotransferase	aspC	0.0089
5490	Aspartate aminotransferase	Not Available	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0088
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0087
86	SEC14-like protein 4	SEC14L4	0.0087
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0087
375	SEC14-like protein 3	SEC14L3	0.0087
4076	Diacylglycerol kinase alpha	DGKA	0.0087
6042	Prostaglandin reductase 2	PTGR2	0.0087
6221	Steroid hormone receptor ERR1	ESRRA	0.0086
461	Glycine receptor subunit alpha-3	GLRA3	0.0086
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0086
634	Squalene monooxygenase	SQLE	0.0085
7196	Squalene monooxygenase	ERG1	0.0085
162	Retinoic acid receptor gamma-1	RARG	0.0085
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0085
3760	Penicillin-binding protein 5 precursor	dacA	0.0085
484	Tyrosine-protein kinase ABL2	ABL2	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
819	Penicillin-binding protein 4	dacB	0.0084
6126	Carbonic anhydrase 7	CA7	0.0084
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0084
1176	Mitogen-activated protein kinase 1	MAPK1	0.0083
2112	Toll-like receptor 9	TLR9	0.0082
708	Alpha-tocopherol transfer protein	TTPA	0.0082
6755	Poliovirus receptor	PVR	0.0082
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0081
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0081
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0081
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0081
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0081
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0081
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0081
54	Prothrombin	F2	0.008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.008
6111	DNA polymerase epsilon subunit 4	POLE4	0.008
1196	Complement decay-accelerating factor	CD55	0.008
6112	DNA polymerase epsilon subunit 3	POLE3	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.008
6110	DNA polymerase epsilon subunit 2	POLE2	0.008
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.008
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.008
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0079
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
459	Retinoic acid receptor RXR-alpha	RXRA	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0078
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0077
6837	Serine/threonine-protein kinase 17B	STK17B	0.0077
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
394	Calcineurin subunit B isoform 1	PPP3R1	0.0077
6753	Apolipoprotein M	APOM	0.0077
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0077
6742	Recoverin	RCVRN	0.0077
6743	Non-fluorescent flavoprotein	luxF	0.0077
2528	Fatty acid metabolism regulator protein	fadR	0.0077
6740	Fatty acid metabolism regulator protein	fadR	0.0077
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0077
6751	Gag polyprotein	gag	0.0077
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0077
6747	Chalcone/stilbene synthase family protein	MT1417	0.0077
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0077
6749	Polyprotein	Not Available	0.0076
4103	Proteasome subunit beta type 2	PSMB2	0.0076
4102	Proteasome subunit beta type 5	PSMB5	0.0076
4101	Proteasome subunit beta type 1	PSMB1	0.0076
2599	Tyrosine-protein kinase HCK	HCK	0.0076
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0075
867	Penicillin-binding protein 3	pbpC	0.0075
6119	Penicillin-binding protein 3	pbp3	0.0075
7154	Penicillin-binding protein 3	pbp3	0.0075
7157	Penicillin-binding protein 3	LMHCC_2184	0.0075
7162	Penicillin-binding protein 3	pbpB	0.0075
7172	Penicillin-binding protein 3	pbp3	0.0075
3957	Adenosine deaminase	ADA	0.0074
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0074
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0074
1541	Metalloproteinase	mmp20	0.0074
760	Fibroblast growth factor 1	FGF1	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0074
1654	Interleukin-1 beta	IL1B	0.0073
899	Glutathione S-transferase Mu 3	GSTM3	0.0072
820	Glycine receptor subunit alpha-2	GLRA2	0.0072
905	Glutathione transferase omega-1	GSTO1	0.0072
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0072
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0072
268	Adenosine A2b receptor	ADORA2B	0.0072
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
6501	Fatty acid-binding protein, liver	FABP1	0.007
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.007
3927	Choline transporter-like protein 3	SLC44A3	0.007
3926	Choline transporter-like protein 2	SLC44A2	0.007
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.007
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.007
1686	Choline transporter-like protein 1	SLC44A1	0.007
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.007
861	Choline kinase alpha	CHKA	0.007
769	High-affinity choline transporter 1	SLC5A7	0.007
3925	Choline transporter-like protein 4	SLC44A4	0.007
700	Choline dehydrogenase, mitochondrial	CHDH	0.007
576	Choline O-acetyltransferase	CHAT	0.007
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.007
3922	Phospholipase D2	PLD2	0.007
3924	Phospholipase D1	PLD1	0.007
2808	Chloramphenicol acetyltransferase 3	cat3	0.0069
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0069
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0069
5961	Insulin	INS	0.0069
1992	Vitamin D-binding protein	GC	0.0069
5798	Mitogen-activated protein kinase 11	MAPK11	0.0069
856	Vitamin D3 receptor	VDR	0.0069
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0068
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0068
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0068
3014	Ribonuclease UK114	HRSP12	0.0068
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0067
5428	Replication protein	repA	0.0067
3617	Non-heme chloroperoxidase	cpo	0.0067
5426	Non-heme chloroperoxidase	cpo	0.0067
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0067
3018	HTH-type transcriptional regulator malT	malT	0.0067
1483	Membrane copper amine oxidase	AOC3	0.0067
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0067
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
1313	Lactoylglutathione lyase	GLO1	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0067
2391	Ferrochelatase	hemH	0.0067
6502	Ferrochelatase	DKFZp686P18130	0.0067
1591	Ferrochelatase, mitochondrial	FECH	0.0067
6527	Lymphocyte antigen 96	LY96	0.0067
810	Heme oxygenase 1	HMOX1	0.0066
3391	Heme oxygenase 1	pbsA1	0.0066
517	Alcohol dehydrogenase 1C	ADH1C	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0066
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0065
1507	Cytochrome c	CYCS	0.0064
2297	Genome polyprotein	Not Available	0.0064
2322	Genome polyprotein	Not Available	0.0064
2694	Genome polyprotein	Not Available	0.0064
2719	Genome polyprotein	Not Available	0.0064
2860	Genome polyprotein	Not Available	0.0064
2928	Genome polyprotein	Not Available	0.0064
3160	Genome polyprotein	Not Available	0.0064
3260	Genome polyprotein	Not Available	0.0064
4783	Genome polyprotein	Not Available	0.0064
5726	Genome polyprotein	Not Available	0.0064
5779	Genome polyprotein	Not Available	0.0064
5867	Genome polyprotein	Not Available	0.0064
6253	Genome polyprotein	Not Available	0.0064
6301	Genome polyprotein	Not Available	0.0064
6380	Genome polyprotein	Not Available	0.0064
6381	Genome polyprotein	Not Available	0.0064
6437	Genome polyprotein	Not Available	0.0064
6520	Genome polyprotein	Not Available	0.0064
6521	Genome polyprotein	Not Available	0.0064
6652	Genome polyprotein	Not Available	0.0064
6734	Genome polyprotein	Not Available	0.0064
6735	Genome polyprotein	Not Available	0.0064
6736	Genome polyprotein	Not Available	0.0064
6737	Genome polyprotein	Not Available	0.0064
6738	Genome polyprotein	Not Available	0.0064
6739	Genome polyprotein	Not Available	0.0064
6744	Genome polyprotein	Not Available	0.0064
6748	Genome polyprotein	Not Available	0.0064
6894	Genome polyprotein	Not Available	0.0064
6898	Genome polyprotein	Not Available	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
581	Cytochrome P450 2R1	CYP2R1	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
518	Peroxidase/catalase T	katG	0.0061
6750	ADP-ribosylation factor 6	ARF6	0.0061
6524	Protein tonB	tonB	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
564	Cellular retinoic acid-binding protein 1	CRABP1	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
494	Caspase-1	CASP1	0.006
6103	Arylamine N-acetyltransferase 1	NAT1	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0059
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0058
3382	Glycolipid transfer protein	GLTP	0.0058
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0058
2958	Probable tautomerase ydcE	pptA	0.0058
2573	Cocaine esterase	cocE	0.0058
7263	Cocaine esterase	Not Available	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
291	Nitric-oxide synthase, endothelial	NOS3	0.0058
229	Retinoic acid receptor beta	RARB	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0058
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0058
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0058
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0058
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0058
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0058
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0058
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0058
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0058
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0058
6559	Cytochrome c oxidase subunit 2	ctaC	0.0058
6669	Cytochrome c oxidase subunit 2	ctaC	0.0058
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0058
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0058
6558	Cytochrome c oxidase subunit 1	ctaD	0.0058
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0058
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0058
3115	Ras-related protein Rab-9	RAB9A	0.0057
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0057
569	Retinal dehydrogenase 2	ALDH1A2	0.0057
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0057
730	Retinoic acid receptor alpha	RARA	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0056
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0055
6316	ADP-ribosylation factor 1	ARF1	0.0055
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0055
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0055
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0055
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0054
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0054
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
6824	Tyrosine-protein kinase Lyn	LYN	0.0054
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0054
3086	Plasmepsin-2	Not Available	0.0053
611	Retinal dehydrogenase 1	ALDH1A1	0.0053
2540	Choloylglycine hydrolase	cbh	0.0053
76	Nitric-oxide synthase, brain	NOS1	0.0053
174	Sigma 1-type opioid receptor	SIGMAR1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0052
6131	Carbonic anhydrase 14	CA14	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0052
719	Retinoic acid receptor responder protein 1	RARRES1	0.0052
770	Retinoic acid-induced protein 3	GPRC5A	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
4226	Uridine phosphorylase 2	UPP2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
3639	Thymidine phosphorylase	deoA	0.0051
3936	Thymidine phosphorylase	TYMP	0.0051
2077	Caspase-3	CASP3	0.005
864	Gag-Pol polyprotein	gag-pol	0.005
2237	Gag-Pol polyprotein	gag-pol	0.005
2326	Gag-Pol polyprotein	gag-pol	0.005
2451	Gag-Pol polyprotein	gag-pol	0.005
2901	Gag-Pol polyprotein	gag-pol	0.005
3165	Gag-Pol polyprotein	gag-pol	0.005
3722	Gag-Pol polyprotein	gag-pol	0.005
6306	Gag-Pol polyprotein	gag-pol	0.005
6624	Gag-Pol polyprotein	gag-pol	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
6122	Carbonic anhydrase 3	CA3	0.0049
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0049
4225	Uridine phosphorylase 1	UPP1	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0047
4692	A/G-specific adenine glycosylase	mutY	0.0047
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0047
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0047
2216	Fibroblast growth factor receptor 4	FGFR4	0.0047
683	Potassium transporter	GK0582	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
128	Adenine phosphoribosyltransferase	APRT	0.0046
277	Purine nucleoside phosphorylase	PNP	0.0046
2870	Purine nucleoside phosphorylase	punA	0.0046
2945	Purine nucleoside phosphorylase	punA	0.0046
4659	Purine nucleoside phosphorylase	TM_1596	0.0046
4825	Purine nucleoside phosphorylase	TTHA1435	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
173	Toll-like receptor 7	TLR7	0.0046
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
413	Amidophosphoribosyltransferase	PPAT	0.0045
2515	Amidophosphoribosyltransferase	purF	0.0045
3714	Amidophosphoribosyltransferase	purF	0.0045
2693	Heat-labile enterotoxin B chain	eltB	0.0044
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0044
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0044
6048	Troponin C, skeletal muscle	TNNC2	0.0044
6211	Tubulin epsilon chain	TUBE1	0.0044
6212	Tubulin gamma-1 chain	TUBG1	0.0044
6210	Tubulin delta chain	TUBD1	0.0044
1039	Histone deacetylase 9	HDAC9	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
6645	D-amino-acid oxidase	DAO	0.0043
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
2427	Ferrichrome-iron receptor	fhuA	0.0043
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0043
714	Glutathione reductase, mitochondrial	GSR	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
1374	Natriuretic peptides B	NPPB	0.0042
1827	Gap junction alpha-1 protein	GJA1	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
1908	Vascular cell adhesion protein 1	VCAM1	0.0042
822	Aldose reductase	AKR1B1	0.0041
6500	Phospholipase A2	PLA2G1B	0.0041
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0041
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
2408	Tyrosine-protein kinase SYK	SYK	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
251	Alcohol dehydrogenase 1A	ADH1A	0.0039
5482	Sialidase-2	NEU2	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3007	Carbonic anhydrase 12	CA12	0.0039
4205	Carbonic anhydrase 9	CA9	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0038
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0038
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0038
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0038
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0038
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0038
444	Alcohol dehydrogenase 1B	ADH1B	0.0038
3685	Catabolite gene activator	crp	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
85	Growth hormone receptor	GHR	0.0038
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
4760	Mll3241 protein	mll3241	0.0032
331	Retinol-binding protein I, cellular	RBP1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
1123	Eosinophil cationic protein	RNASE3	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
6859	Protein S100-A4	S100A4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0023
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0023
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0023
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0023
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0023
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
422	Vitamin K-dependent protein C	PROC	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
4992	Cytochrome c peroxidase	Not Available	0.0018
1253	Interferon gamma	IFNG	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
798	Osteocalcin	BGLAP	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
1243	Cathepsin D	CTSD	0.0016
3233	Bile acid receptor	NR1H4	0.0015
369	Coagulation factor VII	F7	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
2129	Sucrase-isomaltase, intestinal	SI	0.0014
3221	Cytochrome c4	cc4	0.0014
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
1295	Fatty acid synthase	FASN	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
3583	6-phosphogluconolactonase	pgl	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
2298	Cytochrome P450-cam	camC	0.001
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4943	Cytochrome c6	petJ	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
5000	HemO	hemO	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4984	Neuroglobin	NGB	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4909	CooA protein	cooA	0.0008
4910	Cytoglobin	CYGB	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4972	P450cin	cinA	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00783 - Estradiol

Targets

Enzymes

Transporters

Carriers

Predictions