DT-Web

DB00481 - Raloxifene


Identification
Name Raloxifene
Accession Number DB00481 (APRD00400)
Type small molecule
Description A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 473.583
Groups approved
Monoisotopic Weight 473.166079047
Pharmacology
Indication For the prevention and treatment of osteoporosis in post-menopausal women, as well as prevention and treatment of corticosteroid-induced bone loss. Also for the reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis or have a high risk for developing breast cancer.
Mechanism of action Raloxifene binds to estrogen receptors, resulting in differential expression of multiple estrogen-regulated genes in different tissues. Raloxifene produces estrogen-like effects on bone, reducing resorption of bone and increasing bone mineral density in postmenopausal women, thus slowing the rate of bone loss. The maintenance of bone mass by raloxifene and estrogens is, in part, through the regulation of the gene-encoding transforming growth factor-?3 (TGF-?3), which is a bone matrix protein with antiosteoclastic properties. Raloxifene activates TGF-?3 through pathways that are estrogen receptor-mediated but involve DNA sequences distinct from the estrogen response element. The drug also binds to the estrogen receptor and acts as an estrogen agonist in preosteoclastic cells, which results in the inhibtion of their proliferative capacity. This inhibition is thought to contribute to the drug's effect on bone resorption. Other mechanisms include the suppression of activity of the bone-resorbing cytokine interleukin-6 promoter activity. Raloxifene also antagonizes the effects of estrogen on mammary tissue and blocks uterotrophic responses to estrogen. By competing with estrogens for the estrogen receptors in reproductive tissue, raloxifene prevents the transcriptional activation of genes containing the estrogen response element. As well, raloxifene inhibits the estradiol-dependent proliferation of MCF-7 human mammary tumor cells in vitro. The mechansim of action of raloxifene has not been fully determined, but evidence suggests that the drug's tissue-specific estrogen agonist or antagonist activity is related to the structural differences between the raloxifene-estrogen receptor complex (specifically the surface topography of AF-2) and the estrogen-estrogen receptor complex. Also, the existence of at least 2 estrogen receptors (ER?, ER?) may contribute to the tissue specificity of raloxifene.
Absorption Approximately 60% of an oral dose is absorbed, but presystemic glucuronide conjugation is extensive. Absolute bioavailability of raloxifene is 2.0%
Protein binding 95%
Biotransformation Hepatic, raloxifene undergoes extensive first-pass metabolism to the glucuronide conjugates: raloxifene-4'-glucuronide, raloxifene-6-glucuronide, and raloxifene-6, 4'-diglucuronide. No other metabolites have been detected, providing strong evidence that raloxifene is not metabolized by cytochrome P450 pathways
Route of elimination Raloxifene is primarily excreted in feces, and less than 0.2% is excreted unchanged in urine.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Chlorotrianisene Association not recommended
Cholestyramine The resin decreases the effect of raloxifene
Clomifene Association not recommended
Colesevelam Bile Acid Sequestrants may decrease the absorption of Raloxifene. It would seem prudent to separate the doses of raloxifene and bile acid sequestrants by at least 2 hours. The manufacturer of raloxifene recommends against coadministration of these agents.1 The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Colestipol The resin decreases the effect of raloxifene
Conjugated Estrogens Association not recommended
Diethylstilbestrol Association not recommended
Estradiol Association not recommended
Estriol Association not recommended
Estropipate Association not recommended
Ethinyl Estradiol Association not recommended
Levothyroxine Raloxifene decreases absorption of levothyroxine
Mestranol Association not recommended
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions agonist
References
  • Khovidhunkit W, Shoback DM: Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999 Mar 2;130(5):431-9. - Pubmed
  • Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjarnason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC: The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA. 1999 Jun 16;281(23):2189-97. - Pubmed
  • Bryant HU, Glasebrook AL, Yang NN, Sato M: An estrogen receptor basis for raloxifene action in bone. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):37-44. - Pubmed
  • Figtree GA, Lu Y, Webb CM, Collins P: Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism. Circulation. 1999 Sep 7;100(10):1095-101. - Pubmed
  • Schafer JI, Liu H, Tonetti DA, Jordan VC: The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor. Cancer Res. 1999 Sep 1;59(17):4308-13. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Scott JA, Da Camara CC, Early JE: Raloxifene: a selective estrogen receptor modulator. Am Fam Physician. 1999 Sep 15;60(4):1131-9. - Pubmed
  • Matsumoto T: [Selective estrogen receptor modulators (SERMs)] Clin Calcium. 2006 Sep;16(9):1520-25. - Pubmed
  • Moen MD, Keating GM: Raloxifene: a review of its use in the prevention of invasive breast cancer. Drugs. 2008;68(14):2059-83. - Pubmed
DTHybrid score 0.867
Estrogen receptor beta
Name Estrogen receptor beta
Gene Name ESR2
Pharmacological action yes
Actions agonist
References
  • Bryant HU, Glasebrook AL, Yang NN, Sato M: An estrogen receptor basis for raloxifene action in bone. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):37-44. - Pubmed
  • Iannone MA, Consler TG, Pearce KH, Stimmel JB, Parks DJ, Gray JG: Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres. Cytometry. 2001 Aug 1;44(4):326-37. - Pubmed
  • Zhou W, Koldzic-Zivanovic N, Clarke CH, de Beun R, Wassermann K, Bury PS, Cunningham KA, Thomas ML: Selective estrogen receptor modulator effects in the rat brain. Neuroendocrinology. 2002 Jan;75(1):24-33. - Pubmed
  • Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, Katzenellenbogen BS: Antagonists selective for estrogen receptor alpha. Endocrinology. 2002 Mar;143(3):941-7. - Pubmed
  • Kim IY, Seong DH, Kim BC, Lee DK, Remaley AT, Leach F, Morton RA, Kim SJ: Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway. Cancer Res. 2002 Jul 1;62(13):3649-53. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.964

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
DTHybrid score 0.2624
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2513
Aldehyde oxidase
Name Aldehyde oxidase
Gene Name AOX1
Actions inhibitor
References
  • -
  • Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. - Pubmed
  • Obach RS, Huynh P, Allen MC, Beedham C: Human liver aldehyde oxidase: inhibition by 239 drugs. J Clin Pharmacol. 2004 Jan;44(1):7-19. - Pubmed
  • Sahi J, Khan KK, Black CB: Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. Drug Metab Lett. 2008 Aug;2(3):176-83. - Pubmed
DTHybrid score 0.248
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3872
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5159

Predictions


Id Partner name Gene Name Score
6228 Nuclear receptor coactivator 1 NCOA1 0.2566
6241 Nuclear receptor coactivator 2 NCOA2 0.2355
4757 Cytochrome P450 2C9 CYP2C9 0.2158
1588 Multidrug resistance protein 1 ABCB1 0.1745
4200 Cytochrome P450 1A2 CYP1A2 0.1687
6016 Cytochrome P450 2C19 CYP2C19 0.1623
4119 Cytochrome P450 2D6 CYP2D6 0.1558
4118 Cytochrome P450 3A5 CYP3A5 0.1265
6013 Cytochrome P450 2E1 CYP2E1 0.1052
6107 Cytochrome P450 3A7 CYP3A7 0.0972
5718 Cytochrome P450 2A6 CYP2A6 0.0835
146 Androgen receptor AR 0.0835
756 Sex hormone-binding globulin SHBG 0.0817
614 Progesterone receptor PGR 0.0808
6024 Cytochrome P450 1A1 CYP1A1 0.07
587 Serum albumin ALB 0.061
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0587
3947 Xanthine dehydrogenase/oxidase XDH 0.0559
6560 Nuclear receptor coactivator 5 NCOA5 0.0526
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0523
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0464
6142 Solute carrier family 22 member 8 SLC22A8 0.0458
3437 Eosinophil lysophospholipase CLC 0.0424
20 Prostaglandin G/H synthase 1 PTGS1 0.0419
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0403
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0392
6106 Cytochrome P450 2C18 CYP2C18 0.0371
260 Cytochrome P450 51 ERG11 0.035
761 Cytochrome P450 51 ERG11 0.035
3163 Cytochrome P450 51 cyp51 0.035
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0345
2353 Apolipoprotein(a) LPA 0.0343
871 Glucocorticoid receptor NR3C1 0.0339
723 Cytosolic phospholipase A2 PLA2G4A 0.0331
862 Multidrug resistance-associated protein 1 ABCC1 0.0328
1757 Myeloperoxidase MPO 0.0327
1898 Cytochrome P450 1B1 CYP1B1 0.0319
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0314
6143 Solute carrier family 22 member 7 SLC22A7 0.0308
234 Plasminogen PLG 0.0306
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0304
318 Alpha-2A adrenergic receptor ADRA2A 0.0285
492 Histamine H1 receptor HRH1 0.0278
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0278
1792 Tissue-type plasminogen activator PLAT 0.0274
629 Alpha-2B adrenergic receptor ADRA2B 0.0268
776 Bile salt export pump ABCB11 0.0264
338 DNA polymerase UL30 0.0258
379 DNA polymerase UL54 0.0258
697 DNA polymerase ORF28 0.0258
2482 DNA polymerase 43 0.0258
4104 DNA polymerase BALF5 0.0258
847 Mu-type opioid receptor OPRM1 0.0248
2164 Multidrug resistance-associated protein 4 ABCC4 0.0247
226 Gonadotropin-releasing hormone receptor GNRHR 0.024
6145 Solute carrier family 22 member 1 SLC22A1 0.024
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0238
4116 Dihydropteroate synthetase Not Available 0.0234
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0232
563 Thyroid peroxidase TPO 0.0232
824 Sodium-dependent serotonin transporter SLC6A4 0.0228
811 Translocator protein TSPO 0.0224
290 Prostaglandin G/H synthase 2 PTGS2 0.0224
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0223
378 Alpha-2C adrenergic receptor ADRA2C 0.022
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0218
2107 Microtubule-associated protein 1A MAP1A 0.0216
1729 Solute carrier family 22 member 6 SLC22A6 0.0213
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0212
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0198
1852 Microtubule-associated protein 2 MAP2 0.0198
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0191
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0189
467 Delta-type opioid receptor OPRD1 0.0187
373 Transthyretin TTR 0.0182
3941 Amine oxidase [flavin-containing] A MAOA 0.0179
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0174
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0173
6136 Multidrug resistance-associated protein 5 ABCC5 0.0173
468 Cytochrome P450 4A11 CYP4A11 0.0172
502 5-hydroxytryptamine 2A receptor HTR2A 0.0172
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0171
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0169
3923 Cholinesterase BCHE 0.0168
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0163
731 HIV-1 protease HIV-1 protease 0.0161
6144 Solute carrier family 22 member 2 SLC22A2 0.0161
696 Kappa-type opioid receptor OPRK1 0.0159
556 Alpha-1A adrenergic receptor ADRA1A 0.0157
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0155
3809 Estrogen-related receptor gamma ESRRG 0.0153
831 D(2) dopamine receptor DRD2 0.015
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0149
465 Calmodulin CALM1 0.0148
3939 Amine oxidase [flavin-containing] B MAOB 0.0146
380 Cytochrome P450 17A1 CYP17A1 0.0146
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0146
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0142
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0138
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0137
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0136
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0134
713 Sodium-dependent dopamine transporter SLC6A3 0.0132
1024 Solute carrier family 22 member 11 SLC22A11 0.0132
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0131
158 Sodium channel protein type 1 subunit alpha SCN1A 0.013
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.013
6044 Serum paraoxonase/lactonase 3 PON3 0.0129
6141 Sodium/bile acid cotransporter SLC10A1 0.0129
6031 Cytochrome P450 3A43 CYP3A43 0.0129
6147 Solute carrier family 22 member 3 SLC22A3 0.0128
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0124
1656 CYP2B protein CYP2B 0.0123
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0121
6148 Multidrug resistance-associated protein 7 ABCC10 0.0119
122 P2Y purinoceptor 12 P2RY12 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
1649 Small inducible cytokine A2 CCL2 0.0116
4604 Liver carboxylesterase 1 CES1 0.011
1405 Thiopurine S-methyltransferase TPMT 0.0108
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0108
6171 Solute carrier family 28 member 3 SLC28A3 0.0107
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0107
3810 Catechol O-methyltransferase COMT 0.0107
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0106
1010 Cytochrome P450 51A1 CYP51A1 0.0106
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0105
590 5-hydroxytryptamine 2C receptor HTR2C 0.0105
29 Tubulin beta-1 chain TUBB1 0.0104
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0104
118 Organic cation/carnitine transporter 2 SLC22A5 0.0103
817 DNA topoisomerase 2-alpha TOP2A 0.0103
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0103
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0102
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0102
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0101
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0101
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0101
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0099
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0099
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0098
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0097
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0097
6182 Cytochrome P450 2J2 CYP2J2 0.0096
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0096
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0096
992 Protein tyrosine kinase 2 beta PTK2B 0.0095
341 5-hydroxytryptamine 3 receptor HTR3A 0.0095
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0093
381 Prolactin receptor PRLR 0.0093
844 Epidermal growth factor receptor EGFR 0.0093
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0093
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0092
818 50S ribosomal protein L10 rplJ 0.009
4120 NADPH--cytochrome P450 reductase POR 0.009
632 Alpha-1B adrenergic receptor ADRA1B 0.0088
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0088
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0087
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0086
3957 Adenosine deaminase ADA 0.0086
833 Organic cation/carnitine transporter 1 SLC22A4 0.0086
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0086
88 Retinoic acid receptor RXR-beta RXRB 0.0085
504 Mast/stem cell growth factor receptor KIT 0.0085
1192 Sulfotransferase 1A1 SULT1A1 0.0085
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0084
320 5-hydroxytryptamine 1A receptor HTR1A 0.0083
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0083
23 D(1A) dopamine receptor DRD1 0.0083
174 Sigma 1-type opioid receptor SIGMAR1 0.0082
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0082
3917 Methylenetetrahydrofolate reductase MTHFR 0.0082
232 Corticosteroid-binding globulin SERPINA6 0.008
6085 Fatty acid-binding protein, intestinal FABP2 0.0079
400 Coagulation factor IX F9 0.0079
5461 Coagulation factor IX F9 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0078
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0078
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0078
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0077
365 Dihydrofolate reductase DHFR 0.0075
2381 Dihydrofolate reductase DFR1 0.0075
2833 Dihydrofolate reductase Not Available 0.0075
2931 Dihydrofolate reductase folA 0.0075
3544 Dihydrofolate reductase folA 0.0075
3682 Dihydrofolate reductase folA 0.0075
6642 Dihydrofolate reductase folA 0.0075
6756 Dihydrofolate reductase dfrA 0.0075
162 Retinoic acid receptor gamma-1 RARG 0.0075
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0073
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0073
604 Vitamin K-dependent protein Z PROZ 0.0073
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0072
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0072
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0071
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0071
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0071
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0071
1178 Adenosine A2a receptor ADORA2A 0.007
952 Dipeptidyl peptidase 4 DPP4 0.007
780 Retinoic acid receptor RXR-gamma RXRG 0.0069
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0069
766 Beta-2 adrenergic receptor ADRB2 0.0068
891 Dihydropteroate synthase folP 0.0068
5359 Dihydropteroate synthase folP 0.0068
7175 Dihydropteroate synthase sulI 0.0068
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0068
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0068
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0068
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0068
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0068
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0067
789 Alpha-1D adrenergic receptor ADRA1D 0.0067
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0067
229 Retinoic acid receptor beta RARB 0.0067
474 Acetylcholinesterase ACHE 0.0066
422 Vitamin K-dependent protein C PROC 0.0066
1245 Vitamin K-dependent protein S PROS1 0.0066
730 Retinoic acid receptor alpha RARA 0.0066
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
5934 Cytochrome P450 26A1 CYP26A1 0.0065
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0064
705 Glutamate receptor 1 GRIA1 0.0064
638 D(3) dopamine receptor DRD3 0.0064
6137 Multidrug resistance-associated protein 6 ABCC6 0.0063
482 Glycine receptor subunit alpha-1 GLRA1 0.0063
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0062
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0062
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0062
634 Squalene monooxygenase SQLE 0.0062
7196 Squalene monooxygenase ERG1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
6220 Aryl hydrocarbon receptor AHR 0.0061
6014 Cytochrome P450 2A13 CYP2A13 0.006
737 Mineralocorticoid receptor NR3C2 0.006
295 Carbonic anhydrase 1 CA1 0.006
70 Type-1 angiotensin II receptor AGTR1 0.0059
3830 Calreticulin CALR 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
161 Tubulin beta chain TUBB 0.0059
312 Tubulin beta chain TUB2 0.0059
571 Melatonin receptor type 1A MTNR1A 0.0059
362 Melatonin receptor type 1B MTNR1B 0.0059
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0059
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0058
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0058
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0057
407 Vascular endothelial growth factor receptor 2 KDR 0.0057
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0057
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0057
6102 Arylamine N-acetyltransferase 2 NAT2 0.0057
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0056
239 Coagulation factor X F10 0.0056
144 Hemoglobin subunit alpha HBA1 0.0056
592 Carbonic anhydrase 4 CA4 0.0055
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6036 Eosinophil peroxidase EPX 0.0055
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0055
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
4210 Toll-like receptor 4 TLR4 0.0054
84 Nuclear receptor 0B1 NR0B1 0.0054
885 5-hydroxytryptamine 1B receptor HTR1B 0.0054
856 Vitamin D3 receptor VDR 0.0054
738 Monocarboxylate transporter 1 SLC16A1 0.0054
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0053
537 ATP synthase delta chain, mitochondrial ATP5D 0.0053
26 Vascular endothelial growth factor receptor 3 FLT4 0.0053
798 Osteocalcin BGLAP 0.0053
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0053
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0052
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0052
1291 cAMP response element-binding protein CREB1 0.0052
427 Substance-P receptor TACR1 0.0052
725 5-hydroxytryptamine 1D receptor HTR1D 0.0052
3932 Glutathione S-transferase A2 GSTA2 0.0051
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0051
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0051
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0051
32 Vascular endothelial growth factor receptor 1 FLT1 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.005
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.005
1541 Metalloproteinase mmp20 0.0049
5818 Folate receptor alpha FOLR1 0.0049
459 Retinoic acid receptor RXR-alpha RXRA 0.0049
6138 Multidrug resistance protein 3 ABCB4 0.0048
469 Annexin A1 ANXA1 0.0048
765 Indoleamine 2,3-dioxygenase IDO1 0.0048
369 Coagulation factor VII F7 0.0048
228 Beta platelet-derived growth factor receptor PDGFRB 0.0048
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0046
921 Glutamate receptor 2 GRIA2 0.0046
6134 Sodium channel subunit beta-3 SCN3B 0.0046
6128 Carbonic anhydrase-related protein 10 CA10 0.0046
6132 Sodium channel subunit beta-1 SCN1B 0.0046
6135 Sodium channel subunit beta-4 SCN4B 0.0046
6133 Sodium channel subunit beta-2 SCN2B 0.0046
6129 Carbonic anhydrase-related protein 11 CA11 0.0046
6127 Carbonic anhydrase-related protein CA8 0.0046
716 5-hydroxytryptamine 7 receptor HTR7 0.0046
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0046
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0046
6131 Carbonic anhydrase 14 CA14 0.0046
7 Nitric oxide synthase, inducible NOS2 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
193 Beta-1 adrenergic receptor ADRB1 0.0044
267 Plasminogen activator inhibitor 1 SERPINE1 0.0043
6122 Carbonic anhydrase 3 CA3 0.0043
293 Gamma-glutamyl hydrolase GGH 0.0043
94 5-hydroxytryptamine 4 receptor HTR4 0.0042
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0042
814 Ryanodine receptor 1 RYR1 0.0042
6126 Carbonic anhydrase 7 CA7 0.0042
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0041
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0041
357 Carbonic anhydrase 2 CA2 0.0041
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
284 DNA-directed RNA polymerase beta chain rpoB 0.004
5773 DNA-directed RNA polymerase beta chain rpoB 0.004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.004
6130 Carbonic anhydrase 13 CA13 0.004
54 Prothrombin F2 0.004
273 Apoptosis regulator Bcl-2 BCL2 0.0039
6221 Steroid hormone receptor ERR1 ESRRA 0.0039
275 Arachidonate 5-lipoxygenase ALOX5 0.0039
1050 Bile salt sulfotransferase SULT2A1 0.0039
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0039
5923 Microtubule-associated protein tau MAPT 0.0038
5924 Microtubule-associated protein 4 MAP4 0.0038
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0038
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0038
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
777 Tumor necrosis factor TNF 0.0037
436 5-hydroxytryptamine 2B receptor HTR2B 0.0037
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0037
1650 Heme carrier protein 1 SLC46A1 0.0037
2782 Complement C1s subcomponent C1S 0.0037
124 Histamine H2 receptor HRH2 0.0037
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0036
1262 Corticotropin-lipotropin POMC 0.0035
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0034
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0034
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0034
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0034
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0034
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0034
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
432 D(4) dopamine receptor DRD4 0.0034
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0034
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0033
5880 Thrombopoietin receptor MPL 0.0033
3007 Carbonic anhydrase 12 CA12 0.0032
4205 Carbonic anhydrase 9 CA9 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0031
3086 Plasmepsin-2 Not Available 0.0031
5787 Angiopoietin-1 receptor TEK 0.0031
1648 Elastin ELN 0.0031
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.003
4203 Histamine N-methyltransferase HNMT 0.003
1618 High affinity nerve growth factor receptor NTRK1 0.003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.003
1629 Transcription factor AP-1 JUN 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
208 DNA-directed RNA polymerase beta' chain rpoC 0.003
5774 DNA-directed RNA polymerase beta' chain rpoC 0.003
1992 Vitamin D-binding protein GC 0.0029
165 FL cytokine receptor FLT3 0.0029
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0028
319 Opioid receptor, sigma 1 OPRS1 0.0028
131 Synaptic vesicular amine transporter SLC18A2 0.0028
569 Retinal dehydrogenase 2 ALDH1A2 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1630 Integrin beta-2 ITGB2 0.0027
4122 Histone deacetylase 2 HDAC2 0.0027
611 Retinal dehydrogenase 1 ALDH1A1 0.0026
16 Adenosine A1 receptor ADORA1 0.0026
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0026
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0026
49 Endothelin B receptor EDNRB 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0025
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0025
518 Peroxidase/catalase T katG 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
823 Fibroblast growth factor receptor 2 FGFR2 0.0024
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0024
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0024
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0024
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
719 Retinoic acid receptor responder protein 1 RARRES1 0.0023
770 Retinoic acid-induced protein 3 GPRC5A 0.0023
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0023
251 Alcohol dehydrogenase 1A ADH1A 0.0023
904 Glutathione S-transferase P GSTP1 0.0023
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6174 50S ribosomal protein L32 rpmF 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
163 D(1B) dopamine receptor DRD5 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
5798 Mitogen-activated protein kinase 11 MAPK11 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
6146 High affinity copper uptake protein 1 SLC31A1 0.002
6432 Transporter snf 0.002
1256 5-hydroxytryptamine 6 receptor HTR6 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
936 Ephrin type-A receptor 2 EPHA2 0.0019
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0019
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0019
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0019
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0018
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0018
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0017
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0017
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0017
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0016
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
908 Glutathione S-transferase theta-1 GSTT1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
2207 Rhodopsin RHO 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
473 L-lactate dehydrogenase A chain LDHA 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
528 5-hydroxytryptamine 1E receptor HTR1E 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
976 Platelet glycoprotein IX GP9 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
4217 Telomerase reverse transcriptase TERT 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
605 Fumarate reductase flavoprotein subunit frdA 0.0013
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0013
3673 Fumarate reductase flavoprotein subunit fccA 0.0013
4912 Fumarate reductase flavoprotein subunit ifcA 0.0013
6549 Fumarate reductase flavoprotein subunit frdA 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4192 DNA topoisomerase 2-beta TOP2B 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6048 Troponin C, skeletal muscle TNNC2 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
816 Biliverdin reductase A BLVRA 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
572 Integrin alpha-L ITGAL 0.0011
164 Histamine H4 receptor HRH4 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2320 Thymidine kinase, cytosolic TK1 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.001
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.001
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.001
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.001
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.001
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.001
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.001
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.001
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.001
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.001
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.001
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.001
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.001
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.001
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.001
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.001
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.001
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.001
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.001
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.001
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.001
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.001
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
760 Fibroblast growth factor 1 FGF1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
4773 Deoxycytidine kinase DCK 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
810 Heme oxygenase 1 HMOX1 0.0009
3391 Heme oxygenase 1 pbsA1 0.0009
646 Malate dehydrogenase, cytoplasmic MDH1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0009
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0009
6218 Pannexin-1 PANX1 0.0009
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0009
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0009
328 Sorbitol dehydrogenase SORD 0.0009
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0009
1048 Protein S100-A13 S100A13 0.0009
597 Dihydropteridine reductase QDPR 0.0009
2226 Protein S100-A12 S100A12 0.0009
396 Alcohol dehydrogenase 4 ADH4 0.0009
2298 Cytochrome P450-cam camC 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
183 Vascular endothelial growth factor A VEGFA 0.0009
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
6026 Alcohol dehydrogenase 6 ADH6 0.0008
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0008
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0008
626 Cysteine dioxygenase type 1 CDO1 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
627 11-cis retinol dehydrogenase RDH5 0.0008
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
2021 Thrombomodulin THBD 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0007
279 Tyrosinase TYR 0.0007
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
654 Flavin reductase BLVRB 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4984 Neuroglobin NGB 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4909 CooA protein cooA 0.0006
4910 Cytoglobin CYGB 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
5000 HemO hemO 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4961 Hemophore HasA hasA 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
822 Aldose reductase AKR1B1 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
4920 Peroxidase/catalase katG 0.0005
4948 Cytochrome c-553 Not Available 0.0005
4923 Cytochrome c3 DvMF_2499 0.0005
4945 Cytochrome c3 Not Available 0.0005
4949 Cytochrome c3 DVU_3171 0.0005
4968 Cytochrome c3 cytc3 0.0005
4997 Cytochrome c3 SO_2727 0.0005
5219 Cytochrome c3 cyd 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4902 Nine-heme cytochrome c Ddes_2038 0.0005
3189 High-molecular-weight cytochrome c hmcA 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
2230 Catalase CAT 0.0005
3249 Catalase katA 0.0005
3625 Catalase katA 0.0005
4539 Catalase katA 0.0005
4941 Catalase katB 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3127 Nitrite reductase nirS 0.0004
3284 Nitrite reductase nirS 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
3221 Cytochrome c4 cc4 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
358 Cystathionine beta-synthase CBS 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
1507 Cytochrome c CYCS 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
693 Hemoglobin subunit beta HBB 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
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