DT-Web: DB04574

Identification

Name

Estropipate

Accession Number

DB04574

Type

small molecule

Description

Estropipate is a form of estrogen. It has several uses such as: Alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics,treatment of vaginal atrophy,treatment of some types of breast cancer (particularly in men and postmenopausal women), treatment of prostate cancer and prevention of osteoporosis.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

350.429

Groups

approved

Monoisotopic Weight

350.118794504

Pharmacology

Indication

Estropipate is used for the treatment of moderate to severe vasomotor symptoms associated with the monopause, and moderate to severe symptoms of vulval and vaginal atrophy associated with the menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and prevent postmenopausal osteoporosis.

Mechanism of action

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Absorption

Estropipate is well absorbed through the skin and gastrointestinal tract. When applied for a local action, absorption is usually sufficient to cause systemic effects.

Protein binding

Not Available

Biotransformation

Exogenous estrogens are metabolized in the same manner as endogenous estrogens. Circulating estrogens exist in a dynamic equilibrium of metabolic interconversions. These transformations take place mainly in the liver. Estradiol is converted reversibly to estrone, and both can be converted to estriol, which is the major urinary metabolite. Estrogens also undergo enterohepatic recirculation via sulfate and glucuronide conjugation in the liver, biliary secretion of conjugates into the intestine, and hydrolysis in the gut followed by reabsorption. In postmenopausal women, a significant proportion of the circulating estrogens exist as sulfate conjugates, especially estrone sulfate, which serves as a circulating reservoir for the formation of more active estrogens.

Route of elimination

Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Fosphenytoin	The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estropipate.
Griseofulvin	The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, estropipate.
Phenobarbital	The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estropipate.
Phenytoin	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estropipate.
Prednisolone	The estrogenic agent, estropipate, may increase the effect of the corticosteroid, prednisolone.
Prednisone	The estrogenic agent, estropipate, may increase the effect of corticosteroid, prednisone.
Primidone	The enzyme inducer, primidone, decreases the effect of the hormone agent, estropipate.
Raloxifene	Association not recommended

Food Interactions

Take with food to decrease nausea

Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	yes
Actions	agonist
References	Brama M, Gnessi L, Basciani S, Cerulli N, Politi L, Spera G, Mariani S, Cherubini S, d'Abusco AS, Scandurra R, Migliaccio S: Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):102-8. Epub 2006 Nov 27. - Pubmed Lehnes K, Winder AD, Alfonso C, Kasid N, Simoneaux M, Summe H, Morgan E, Iann MC, Duncan J, Eagan M, Tavaluc R, Evans CH Jr, Russell R, Wang A, Hu F, Stoica A: The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway. Endocrinology. 2007 Mar;148(3):1171-80. Epub 2006 Nov 30. - Pubmed Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.8695
Estrogen receptor beta
Name	Estrogen receptor beta
Gene Name	ESR2
Pharmacological action	unknown
Actions	agonist
References	Vijayanathan V, Greenfield NJ, Thomas TJ, Ivanova MM, Tyulmenkov VV, Klinge CM, Gallo MA, Thomas T: Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta. Biochem Cell Biol. 2007 Feb;85(1):1-10. - Pubmed Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed
DTHybrid score	1.005

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. - Pubmed Williams ET, Leyk M, Wrighton SA, Davies PJ, Loose DS, Shipley GL, Strobel HW: Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther. 2004 Nov;311(2):728-35. Epub 2004 Jul 28. - Pubmed
DTHybrid score	0.5081
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. - Pubmed
DTHybrid score	0.3521
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inducer
References	Egnell AC, Eriksson C, Albertson N, Houston B, Boyer S: Generation and evaluation of a CYP2C9 heteroactivation pharmacophore. J Pharmacol Exp Ther. 2003 Dec;307(3):878-87. Epub 2003 Oct 13. - Pubmed
DTHybrid score	0.355

Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.2308

Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.2308

Id	Partner name	Gene Name	Score
6228	Nuclear receptor coactivator 1	NCOA1	0.2576
6241	Nuclear receptor coactivator 2	NCOA2	0.2362
1588	Multidrug resistance protein 1	ABCB1	0.2155
6016	Cytochrome P450 2C19	CYP2C19	0.2077
4119	Cytochrome P450 2D6	CYP2D6	0.1986
4924	Cytochrome P450 2C8	CYP2C8	0.1756
4118	Cytochrome P450 3A5	CYP3A5	0.1457
6030	Cytochrome P450 2B6	CYP2B6	0.1232
3811	Cytochrome P450 19A1	CYP19A1	0.1214
6107	Cytochrome P450 3A7	CYP3A7	0.1068
6013	Cytochrome P450 2E1	CYP2E1	0.1024
146	Androgen receptor	AR	0.1008
614	Progesterone receptor	PGR	0.0972
6024	Cytochrome P450 1A1	CYP1A1	0.096
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0834
6144	Solute carrier family 22 member 2	SLC22A2	0.0831
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0828
20	Prostaglandin G/H synthase 1	PTGS1	0.0786
5718	Cytochrome P450 2A6	CYP2A6	0.0658
1729	Solute carrier family 22 member 6	SLC22A6	0.0611
1181	Alpha-1-acid glycoprotein 1	ORM1	0.061
6142	Solute carrier family 22 member 8	SLC22A8	0.0579
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0526
6560	Nuclear receptor coactivator 5	NCOA5	0.0526
290	Prostaglandin G/H synthase 2	PTGS2	0.052
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0508
6147	Solute carrier family 22 member 3	SLC22A3	0.0471
871	Glucocorticoid receptor	NR3C1	0.0465
118	Organic cation/carnitine transporter 2	SLC22A5	0.0453
381	Prolactin receptor	PRLR	0.044
862	Multidrug resistance-associated protein 1	ABCC1	0.0432
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0428
3437	Eosinophil lysophospholipase	CLC	0.0424
492	Histamine H1 receptor	HRH1	0.0404
831	D(2) dopamine receptor	DRD2	0.0399
1898	Cytochrome P450 1B1	CYP1B1	0.0394
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0375
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0366
556	Alpha-1A adrenergic receptor	ADRA1A	0.0364
833	Organic cation/carnitine transporter 1	SLC22A4	0.0349
269	Adrenodoxin, mitochondrial	FDX1	0.0348
23	D(1A) dopamine receptor	DRD1	0.0348
6106	Cytochrome P450 2C18	CYP2C18	0.0332
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.033
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0329
36	Insulin receptor	INSR	0.0325
891	Dihydropteroate synthase	folP	0.0323
5359	Dihydropteroate synthase	folP	0.0323
7175	Dihydropteroate synthase	sulI	0.0323
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.032
232	Corticosteroid-binding globulin	SERPINA6	0.0309
6143	Solute carrier family 22 member 7	SLC22A7	0.0307
824	Sodium-dependent serotonin transporter	SLC6A4	0.03
318	Alpha-2A adrenergic receptor	ADRA2A	0.0298
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0297
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0295
1024	Solute carrier family 22 member 11	SLC22A11	0.0291
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.029
776	Bile salt export pump	ABCB11	0.0287
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0284
632	Alpha-1B adrenergic receptor	ADRA1B	0.0283
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0275
2164	Multidrug resistance-associated protein 4	ABCC4	0.0264
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0257
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0257
380	Cytochrome P450 17A1	CYP17A1	0.0241
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0232
617	Muscarinic acetylcholine receptor M2	CHRM2	0.023
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0225
3941	Amine oxidase [flavin-containing] A	MAOA	0.0221
1649	Small inducible cytokine A2	CCL2	0.022
2107	Microtubule-associated protein 1A	MAP1A	0.0216
731	HIV-1 protease	HIV-1 protease	0.0215
817	DNA topoisomerase 2-alpha	TOP2A	0.0215
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0213
766	Beta-2 adrenergic receptor	ADRB2	0.0207
6141	Sodium/bile acid cotransporter	SLC10A1	0.0204
373	Transthyretin	TTR	0.0203
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0202
629	Alpha-2B adrenergic receptor	ADRA2B	0.0199
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0195
847	Mu-type opioid receptor	OPRM1	0.0192
3923	Cholinesterase	BCHE	0.019
378	Alpha-2C adrenergic receptor	ADRA2C	0.0186
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0183
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0182
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.018
103	Muscarinic acetylcholine receptor M1	CHRM1	0.018
193	Beta-1 adrenergic receptor	ADRB1	0.0179
789	Alpha-1D adrenergic receptor	ADRA1D	0.0178
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0177
1852	Microtubule-associated protein 2	MAP2	0.0173
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.017
713	Sodium-dependent dopamine transporter	SLC6A3	0.017
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.017
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
6148	Multidrug resistance-associated protein 7	ABCC10	0.0166
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0164
467	Delta-type opioid receptor	OPRD1	0.0163
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0162
3939	Amine oxidase [flavin-containing] B	MAOB	0.0162
696	Kappa-type opioid receptor	OPRK1	0.0162
6085	Fatty acid-binding protein, intestinal	FABP2	0.0161
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0161
6020	Aldehyde oxidase	AOX1	0.0155
122	P2Y purinoceptor 12	P2RY12	0.0155
474	Acetylcholinesterase	ACHE	0.0147
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0147
477	DNA topoisomerase 4 subunit A	parC	0.0146
886	DNA topoisomerase 4 subunit A	parC	0.0146
6226	DNA topoisomerase 4 subunit A	parC	0.0146
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0144
404	DNA gyrase subunit A	gyrA	0.0144
6224	DNA gyrase subunit A	gyrA	0.0144
6014	Cytochrome P450 2A13	CYP2A13	0.0143
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0143
465	Calmodulin	CALM1	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0141
70	Type-1 angiotensin II receptor	AGTR1	0.014
992	Protein tyrosine kinase 2 beta	PTK2B	0.014
6031	Cytochrome P450 3A43	CYP3A43	0.0139
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0139
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0138
3810	Catechol O-methyltransferase	COMT	0.0138
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0135
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0135
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0135
638	D(3) dopamine receptor	DRD3	0.0129
260	Cytochrome P450 51	ERG11	0.0127
761	Cytochrome P450 51	ERG11	0.0127
3163	Cytochrome P450 51	cyp51	0.0127
4604	Liver carboxylesterase 1	CES1	0.0126
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0125
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0123
469	Annexin A1	ANXA1	0.0122
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0122
468	Cytochrome P450 4A11	CYP4A11	0.0121
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0119
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0118
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0117
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0115
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0114
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0114
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0113
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0112
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0112
571	Melatonin receptor type 1A	MTNR1A	0.0111
362	Melatonin receptor type 1B	MTNR1B	0.0111
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0108
432	D(4) dopamine receptor	DRD4	0.0108
482	Glycine receptor subunit alpha-1	GLRA1	0.0108
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0102
124	Histamine H2 receptor	HRH2	0.0102
811	Translocator protein	TSPO	0.0098
2211	Fatty acid-binding protein, heart	FABP3	0.0098
705	Glutamate receptor 1	GRIA1	0.0098
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
738	Monocarboxylate transporter 1	SLC16A1	0.0096
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0096
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0095
566	Serotransferrin	TF	0.0094
1757	Myeloperoxidase	MPO	0.0094
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0094
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0093
3809	Estrogen-related receptor gamma	ESRRG	0.0093
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0093
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0092
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0091
183	Vascular endothelial growth factor A	VEGFA	0.0091
844	Epidermal growth factor receptor	EGFR	0.0091
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.009
3947	Xanthine dehydrogenase/oxidase	XDH	0.009
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.009
672	Prostaglandin F2-alpha receptor	PTGFR	0.009
818	50S ribosomal protein L10	rplJ	0.0089
6136	Multidrug resistance-associated protein 5	ABCC5	0.0088
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0088
16	Adenosine A1 receptor	ADORA1	0.0088
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0088
6220	Aryl hydrocarbon receptor	AHR	0.0087
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0085
777	Tumor necrosis factor	TNF	0.0085
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0085
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0085
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0085
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0085
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0085
163	D(1B) dopamine receptor	DRD5	0.0082
6102	Arylamine N-acetyltransferase 2	NAT2	0.0082
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0082
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0078
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0078
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0078
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0077
504	Mast/stem cell growth factor receptor	KIT	0.0076
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0075
6137	Multidrug resistance-associated protein 6	ABCC6	0.0075
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0074
1178	Adenosine A2a receptor	ADORA2A	0.0074
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0074
4773	Deoxycytidine kinase	DCK	0.0074
6010	Thiamine transporter 1	SLC19A2	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
459	Retinoic acid receptor RXR-alpha	RXRA	0.0071
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.007
6043	Putative G-protein coupled receptor 44	GPR44	0.007
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0069
49	Endothelin B receptor	EDNRB	0.0069
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0069
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
6182	Cytochrome P450 2J2	CYP2J2	0.0068
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0068
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0068
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0068
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0068
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0068
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0067
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0067
1517	Beta-3 adrenergic receptor	ADRB3	0.0067
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
592	Carbonic anhydrase 4	CA4	0.0067
295	Carbonic anhydrase 1	CA1	0.0067
1656	CYP2B protein	CYP2B	0.0066
6149	Solute carrier family 22 member 10	SLC22A10	0.0066
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
1192	Sulfotransferase 1A1	SULT1A1	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0065
6070	Nischarin	NISCH	0.0065
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0065
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0063
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
407	Vascular endothelial growth factor receptor 2	KDR	0.0063
275	Arachidonate 5-lipoxygenase	ALOX5	0.0063
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
4210	Toll-like receptor 4	TLR4	0.0062
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0062
716	5-hydroxytryptamine 7 receptor	HTR7	0.0062
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0062
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0061
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0061
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0061
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.006
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.006
357	Carbonic anhydrase 2	CA2	0.006
780	Retinoic acid receptor RXR-gamma	RXRG	0.0059
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0059
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0059
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0059
1830	5'-nucleotidase	NT5E	0.0059
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0058
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0058
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0058
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0057
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0057
94	5-hydroxytryptamine 4 receptor	HTR4	0.0057
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0057
365	Dihydrofolate reductase	DHFR	0.0056
2381	Dihydrofolate reductase	DFR1	0.0056
2833	Dihydrofolate reductase	Not Available	0.0056
2931	Dihydrofolate reductase	folA	0.0056
3544	Dihydrofolate reductase	folA	0.0056
3682	Dihydrofolate reductase	folA	0.0056
6642	Dihydrofolate reductase	folA	0.0056
6756	Dihydrofolate reductase	dfrA	0.0056
427	Substance-P receptor	TACR1	0.0056
737	Mineralocorticoid receptor	NR3C2	0.0056
4122	Histone deacetylase 2	HDAC2	0.0056
1291	cAMP response element-binding protein	CREB1	0.0056
273	Apoptosis regulator Bcl-2	BCL2	0.0055
558	Solute carrier family 12 member 1	SLC12A1	0.0055
88	Retinoic acid receptor RXR-beta	RXRB	0.0054
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0054
6432	Transporter	snf	0.0054
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0054
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0053
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0053
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
4203	Histamine N-methyltransferase	HNMT	0.0053
565	Extracellular calcium-sensing receptor	CASR	0.0052
828	Phenylalanine-4-hydroxylase	PAH	0.0052
3109	Phenylalanine-4-hydroxylase	phhA	0.0052
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0052
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0052
712	Tubulin alpha chain	TUB1	0.0052
29	Tubulin beta-1 chain	TUBB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
1618	High affinity nerve growth factor receptor	NTRK1	0.0052
284	DNA-directed RNA polymerase beta chain	rpoB	0.0051
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0051
3611	Cytidine deaminase	cdd	0.005
3707	Cytidine deaminase	cdd	0.005
4211	Cytidine deaminase	CDA	0.005
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
6167	Organic solute transporter subunit beta	OSTB	0.005
6166	Organic solute transporter subunit alpha	OSTA	0.005
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.005
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.005
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.005
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.005
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
904	Glutathione S-transferase P	GSTP1	0.0049
6171	Solute carrier family 28 member 3	SLC28A3	0.0049
24	Thymidylate synthase	TMP1	0.0049
359	Thymidylate synthase	TYMS	0.0049
2626	Thymidylate synthase	thyA	0.0049
2729	Thymidylate synthase	thyA	0.0049
5352	Thymidylate synthase	THYA	0.0049
3932	Glutathione S-transferase A2	GSTA2	0.0048
153	Dopamine beta-hydroxylase	DBH	0.0048
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
26	Vascular endothelial growth factor receptor 3	FLT4	0.0048
164	Histamine H4 receptor	HRH4	0.0048
1050	Bile salt sulfotransferase	SULT2A1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0047
814	Ryanodine receptor 1	RYR1	0.0046
33	Cystine/glutamate transporter	SLC7A11	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0046
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
32	Vascular endothelial growth factor receptor 1	FLT1	0.0046
173	Toll-like receptor 7	TLR7	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
768	FK506-binding protein 1A	FKBP1A	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0044
1010	Cytochrome P450 51A1	CYP51A1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
1275	Estrogen sulfotransferase	SULT1E1	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0043
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0043
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0043
952	Dipeptidyl peptidase 4	DPP4	0.0043
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0043
1341	Histamine H3 receptor	HRH3	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0042
6103	Arylamine N-acetyltransferase 1	NAT1	0.0042
1648	Elastin	ELN	0.0041
161	Tubulin beta chain	TUBB	0.0041
312	Tubulin beta chain	TUB2	0.0041
6146	High affinity copper uptake protein 1	SLC31A1	0.0041
3830	Calreticulin	CALR	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
125	DNA polymerase beta	POLB	0.0041
856	Vitamin D3 receptor	VDR	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
921	Glutamate receptor 2	GRIA2	0.0041
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
131	Synaptic vesicular amine transporter	SLC18A2	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
54	Prothrombin	F2	0.004
976	Platelet glycoprotein IX	GP9	0.0039
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0039
1541	Metalloproteinase	mmp20	0.0039
694	Matrix protein 2	M	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
6035	Nuclear receptor ROR-beta	RORB	0.0038
6034	Hydroxyindole O-methyltransferase	ASMT	0.0038
6036	Eosinophil peroxidase	EPX	0.0038
4120	NADPH--cytochrome P450 reductase	POR	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
2472	Voltage-gated potassium channel	kcsA	0.0038
6366	Voltage-gated potassium channel	kcsA	0.0038
1864	RET proto-oncogene	RET	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0038
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0038
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0038
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0037
1629	Transcription factor AP-1	JUN	0.0037
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0037
6044	Serum paraoxonase/lactonase 3	PON3	0.0037
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0036
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0036
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0034
5787	Angiopoietin-1 receptor	TEK	0.0033
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
765	Indoleamine 2,3-dioxygenase	IDO1	0.0033
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0033
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
3639	Thymidine phosphorylase	deoA	0.0032
3936	Thymidine phosphorylase	TYMP	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1867	Major prion protein	PRNP	0.0032
1714	Mitogen-activated protein kinase 3	MAPK3	0.0032
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0032
518	Peroxidase/catalase T	katG	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
1992	Vitamin D-binding protein	GC	0.0031
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0031
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0031
908	Glutathione S-transferase theta-1	GSTT1	0.0031
5934	Cytochrome P450 26A1	CYP26A1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
5626	Nucleoside diphosphate kinase B	NME2	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.003
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.003
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.003
162	Retinoic acid receptor gamma-1	RARG	0.003
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
6218	Pannexin-1	PANX1	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
5126	Arginase	rocF	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
3957	Adenosine deaminase	ADA	0.0029
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0028
233	Potassium channel subfamily K member 2	KCNK2	0.0028
239	Coagulation factor X	F10	0.0028
896	Glutathione S-transferase Mu 1	GSTM1	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
823	Fibroblast growth factor receptor 2	FGFR2	0.0027
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0027
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
563	Thyroid peroxidase	TPO	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6111	DNA polymerase epsilon subunit 4	POLE4	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
740	Argininosuccinate synthase	ASS1	0.0027
865	Argininosuccinate synthase	ASS1	0.0027
2680	Argininosuccinate synthase	argG	0.0027
3194	Argininosuccinate synthase	argG	0.0027
6112	DNA polymerase epsilon subunit 3	POLE3	0.0027
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0026
6110	DNA polymerase epsilon subunit 2	POLE2	0.0026
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
229	Retinoic acid receptor beta	RARB	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
4226	Uridine phosphorylase 2	UPP2	0.0026
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0026
730	Retinoic acid receptor alpha	RARA	0.0026
751	Potassium channel subfamily K member 6	KCNK6	0.0026
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0026
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0026
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0026
634	Squalene monooxygenase	SQLE	0.0025
7196	Squalene monooxygenase	ERG1	0.0025
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0025
6165	Copper-transporting ATPase 1	ATP7A	0.0025
6163	Copper-transporting ATPase 2	ATP7B	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
5294	Nucleoside diphosphate kinase A	NME1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4225	Uridine phosphorylase 1	UPP1	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0024
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0024
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0024
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0024
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
172	Potassium channel subfamily K member 1	KCNK1	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0023
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0023
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0023
3937	Fatty-acid amide hydrolase	FAAH	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
581	Cytochrome P450 2R1	CYP2R1	0.0023
4217	Telomerase reverse transcriptase	TERT	0.0022
413	Amidophosphoribosyltransferase	PPAT	0.0022
2515	Amidophosphoribosyltransferase	purF	0.0022
3714	Amidophosphoribosyltransferase	purF	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
707	72 kDa type IV collagenase	MMP2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2207	Rhodopsin	RHO	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
244	Angiotensin-converting enzyme	ACE	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
6501	Fatty acid-binding protein, liver	FABP1	0.002
1360	Sphingomyelin phosphodiesterase	SMPD1	0.002
342	P protein [Includes: DNA-directed DNA polymerase	P	0.002
612	P protein [Includes: DNA-directed DNA polymerase	P	0.002
603	DNA polymerase alpha catalytic subunit	POLA1	0.002
1820	Beta-nerve growth factor	NGF	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
822	Aldose reductase	AKR1B1	0.002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0019
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0019
489	Monocarboxylate transporter 2	SLC16A7	0.0019
4311	tRNA	TRDMT1	0.0019
4325	tRNA	trmD	0.0019
4328	tRNA	trmD	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0018
4103	Proteasome subunit beta type 2	PSMB2	0.0018
4102	Proteasome subunit beta type 5	PSMB5	0.0018
4101	Proteasome subunit beta type 1	PSMB1	0.0018
1374	Natriuretic peptides B	NPPB	0.0018
1827	Gap junction alpha-1 protein	GJA1	0.0018
1908	Vascular cell adhesion protein 1	VCAM1	0.0018
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0018
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0017
165	FL cytokine receptor	FLT3	0.0017
702	UMP-CMP kinase	CMPK1	0.0017
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0017
2300	Lysozyme	E	0.0017
3633	Lysozyme	R	0.0017
5597	Lysozyme	17	0.0017
6174	50S ribosomal protein L32	rpmF	0.0017
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
4192	DNA topoisomerase 2-beta	TOP2B	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0017
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0016
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
3924	Phospholipase D1	PLD1	0.0016
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0016
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
1243	Cathepsin D	CTSD	0.0016
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
936	Ephrin type-A receptor 2	EPHA2	0.0016
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
268	Adenosine A2b receptor	ADORA2B	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2021	Thrombomodulin	THBD	0.0015
277	Purine nucleoside phosphorylase	PNP	0.0015
2870	Purine nucleoside phosphorylase	punA	0.0015
2945	Purine nucleoside phosphorylase	punA	0.0015
4659	Purine nucleoside phosphorylase	TM_1596	0.0015
4825	Purine nucleoside phosphorylase	TTHA1435	0.0015
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0015
3856	Fibroblast growth factor receptor 3	FGFR3	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
444	Alcohol dehydrogenase 1B	ADH1B	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
84	Nuclear receptor 0B1	NR0B1	0.0014
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0014
6859	Protein S100-A4	S100A4	0.0014
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0014
7	Nitric oxide synthase, inducible	NOS2	0.0014
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
6151	Monocarboxylate transporter 10	SLC16A10	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
3808	Dihydropteroate synthase 2	folP2	0.0013
3601	Dihydropteroate synthase 1	folP1	0.0013
3807	Dihydropteroate synthase 1	folP1	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0013
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0013
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0013
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0013
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0013
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0013
6459	Glycodelin	PAEP	0.0013
517	Alcohol dehydrogenase 1C	ADH1C	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0012
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
1039	Histone deacetylase 9	HDAC9	0.0012
3587	Gastrotropin	FABP6	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
319	Opioid receptor, sigma 1	OPRS1	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0011
6042	Prostaglandin reductase 2	PTGR2	0.0011
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1630	Integrin beta-2	ITGB2	0.0011
1792	Tissue-type plasminogen activator	PLAT	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.001
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
4948	Cytochrome c-553	Not Available	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
174	Sigma 1-type opioid receptor	SIGMAR1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
291	Nitric-oxide synthase, endothelial	NOS3	0.0009
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
1313	Lactoylglutathione lyase	GLO1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2298	Cytochrome P450-cam	camC	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
572	Integrin alpha-L	ITGAL	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
267	Plasminogen activator inhibitor 1	SERPINE1	0.0008
760	Fibroblast growth factor 1	FGF1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
3221	Cytochrome c4	cc4	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
6221	Steroid hormone receptor ERR1	ESRRA	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
1507	Cytochrome c	CYCS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
293	Gamma-glutamyl hydrolase	GGH	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
1650	Heme carrier protein 1	SLC46A1	0.0006
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4943	Cytochrome c6	petJ	0.0006
4916	Cyanoglobin	glbN	0.0006
5000	HemO	hemO	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4984	Neuroglobin	NGB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
3116	Bacterioferritin	bfr	0.0006
4906	Bacterioferritin	bfr	0.0006
4965	Bacterioferritin	bfr	0.0006
4909	CooA protein	cooA	0.0006
4961	Hemophore HasA	hasA	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4972	P450cin	cinA	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
798	Osteocalcin	BGLAP	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
5961	Insulin	INS	0.0005
369	Coagulation factor VII	F7	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
6755	Poliovirus receptor	PVR	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4920	Peroxidase/catalase	katG	0.0004
6524	Protein tonB	tonB	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB04574 - Estropipate

Targets

Enzymes

Transporters

Carriers

Predictions