DT-Web

DB00255 - Diethylstilbestrol


Identification
Name Diethylstilbestrol
Accession Number DB00255 (APRD00920, EXPT01164)
Type small molecule
Description A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 268.3502
Groups approved
Monoisotopic Weight 268.146329884
Pharmacology
Indication Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
Mechanism of action Estrogens diffuse into their target cells and interact with a protein receptor, the estrogen receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. The effect of Estrogen binding their receptors causes downstream increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amobarbital The enzyme inducer, amobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Aprobarbital The enzyme inducer, aprobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Butabarbital The enzyme inducer, butabarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Butalbital The enzyme inducer, butalbital, decreases the effect of the hormone agent, diethylstilbestrol.
Butethal The enzyme inducer, butethal, decreases the effect of the hormone agent, diethylstilbestrol.
Ethotoin The enzyme inducer, ethotoin, decreases the effect of the hormone agent, diethylstilbestrol.
Fosphenytoin The enzyme inducer, fosphenytoin, may decrease the therapeutic effect of diethylstilbestrol.
Griseofulvin The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, diethylstilbestrol.
Heptabarbital The enzyme inducer, heptabarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Hexobarbital The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Mephenytoin The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, diethylstilbestrol.
Methohexital The enzyme inducer, methohexital, decreases the effect of the hormone agent, diethylstilbestrol.
Methylphenobarbital The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Pentobarbital The enzyme inducer, pentobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Phenobarbital The enzyme inducer, phenobarbital, may decrease the therapeutic effect of diethylstilbestrol.
Phenytoin The enzyme inducer, phenytoin, decreases the effect of the hormone agent, diethylstilbestrol.
Prednisolone The estrogenic agent, diethylstilbestrol, may increase the effect of the corticosteroid, prednisolone.
Prednisone The estrogenic agent, diethylstilbestrol, may increase the effect of corticosteroid, prednisone.
Primidone The enzyme inducer, primidone, may decrease the effect of the hormone agent, diethylstilbestrol.
Raloxifene Association not recommended
Secobarbital The enzyme inducer, secobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Talbutal The enzyme inducer, talbutal, decreases the effect of the hormone agent, diethylstilbestrol.
Tipranavir Diethylstilbestrol may increase the adverse dermatological effects (i.e. skin rash) of Tipranavir. Tipranavir may decrease the serum concentration Diethylstilbestrol. Monitor estrogen levels during concomitant therapy.
Ursodeoxycholic acid Estrogens decreases the effect of ursodiol
Food Interactions Not Available

Targets


Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions agonist
References
  • Munoz G, Ovilo C, Estelle J, Silio L, Fernandez A, Rodriguez C: Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line. Genet Sel Evol. 2007 Mar-Apr;39(2):195-206. Epub 2007 Feb 17. - Pubmed
  • Dixon A, Wells CC, Singh S, Babayan R, Maric C: Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy. Am J Nephrol. 2007;27(2):120-8. Epub 2007 Feb 15. - Pubmed
  • Hart SA, Snyder MA, Smejkalova T, Woolley CS: Estrogen mobilizes a subset of estrogen receptor-alpha-immunoreactive vesicles in inhibitory presynaptic boutons in hippocampal CA1. J Neurosci. 2007 Feb 21;27(8):2102-11. - Pubmed
  • Baron S, Escande A, Alberola G, Bystricky K, Balaguer P, Richard-Foy H: Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene. J Biol Chem. 2007 Apr 20;282(16):11732-41. Epub 2007 Feb 22. - Pubmed
  • Bains M, Cousins JC, Roberts JL: Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon. Exp Neurol. 2007 Apr;204(2):767-76. Epub 2007 Jan 25. - Pubmed
  • Kwok KC, Cheung NH: Measuring binding kinetics of ligands with tethered receptors by fluorescence polarization and total internal reflection fluorescence. Anal Chem. 2010 May 1;82(9):3819-25. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9017
Estrogen-related receptor gamma
Name Estrogen-related receptor gamma
Gene Name ESRRG
Pharmacological action yes
Actions agonist
References
  • Greschik H, Flaig R, Renaud JP, Moras D: Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. J Biol Chem. 2004 Aug 6;279(32):33639-46. Epub 2004 May 24. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9352
Estrogen receptor beta
Name Estrogen receptor beta
Gene Name ESR2
Pharmacological action yes
Actions agonist
References
  • Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82. - Pubmed
  • Geistlinger TR, McReynolds AC, Guy RK: Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Chem Biol. 2004 Feb;11(2):273-81. - Pubmed
DTHybrid score 0.9886

Enzymes


Catechol O-methyltransferase
Name Catechol O-methyltransferase
Gene Name COMT
Actions substrate
References
  • Engel LL, Weidenfield J, Merriam GR: Metabolism of diethylstilbestrol by rat liver: a preliminary report. J Toxicol Environ Health Suppl. 1976;1:37-44. - Pubmed
DTHybrid score 0.8109
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4271
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Qu YQ, Fang ZZ, Yang L, Gao ZM, Liang R, Zhu LL, Dong PP, Zhang YY, Ge GB, Wang LM: Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21. - Pubmed
DTHybrid score 0.3503
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Qu YQ, Fang ZZ, Yang L, Gao ZM, Liang R, Zhu LL, Dong PP, Zhang YY, Ge GB, Wang LM: Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21. - Pubmed
DTHybrid score 0.7254
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Qu YQ, Fang ZZ, Yang L, Gao ZM, Liang R, Zhu LL, Dong PP, Zhang YY, Ge GB, Wang LM: Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21. - Pubmed
DTHybrid score 0.3955
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Qu YQ, Fang ZZ, Yang L, Gao ZM, Liang R, Zhu LL, Dong PP, Zhang YY, Ge GB, Wang LM: Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21. - Pubmed
DTHybrid score 0.5302
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Qu YQ, Fang ZZ, Yang L, Gao ZM, Liang R, Zhu LL, Dong PP, Zhang YY, Ge GB, Wang LM: Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21. - Pubmed
DTHybrid score 0.3403

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T: Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther. 2003 Jan;2(1):105-12. - Pubmed
DTHybrid score 0.2738
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Rao US, Fine RL, Scarborough GA: Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. - Pubmed
DTHybrid score 0.4907

Carriers


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.2738
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.4907

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.326
4200 Cytochrome P450 1A2 CYP1A2 0.3032
4119 Cytochrome P450 2D6 CYP2D6 0.2949
6228 Nuclear receptor coactivator 1 NCOA1 0.2627
6241 Nuclear receptor coactivator 2 NCOA2 0.2415
4118 Cytochrome P450 3A5 CYP3A5 0.2142
6030 Cytochrome P450 2B6 CYP2B6 0.2111
6243 Nuclear receptor-interacting protein 1 NRIP1 0.1619
6107 Cytochrome P450 3A7 CYP3A7 0.1544
6024 Cytochrome P450 1A1 CYP1A1 0.1536
587 Serum albumin ALB 0.1193
146 Androgen receptor AR 0.1129
20 Prostaglandin G/H synthase 1 PTGS1 0.1083
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1034
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0991
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0941
862 Multidrug resistance-associated protein 1 ABCC1 0.0904
614 Progesterone receptor PGR 0.0872
756 Sex hormone-binding globulin SHBG 0.0868
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.082
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0757
1898 Cytochrome P450 1B1 CYP1B1 0.069
290 Prostaglandin G/H synthase 2 PTGS2 0.067
776 Bile salt export pump ABCB11 0.0661
1729 Solute carrier family 22 member 6 SLC22A6 0.0653
6106 Cytochrome P450 2C18 CYP2C18 0.0627
3941 Amine oxidase [flavin-containing] A MAOA 0.0561
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.056
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0559
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0557
6560 Nuclear receptor coactivator 5 NCOA5 0.0526
6145 Solute carrier family 22 member 1 SLC22A1 0.0518
5455 Arylsulfatase A ARSA 0.0518
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0514
6142 Solute carrier family 22 member 8 SLC22A8 0.0506
260 Cytochrome P450 51 ERG11 0.0505
761 Cytochrome P450 51 ERG11 0.0505
3163 Cytochrome P450 51 cyp51 0.0505
3939 Amine oxidase [flavin-containing] B MAOB 0.05
871 Glucocorticoid receptor NR3C1 0.0491
492 Histamine H1 receptor HRH1 0.0468
2164 Multidrug resistance-associated protein 4 ABCC4 0.0445
766 Beta-2 adrenergic receptor ADRB2 0.0445
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0434
6144 Solute carrier family 22 member 2 SLC22A2 0.0432
3437 Eosinophil lysophospholipase CLC 0.0424
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0419
824 Sodium-dependent serotonin transporter SLC6A4 0.0404
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0399
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.039
318 Alpha-2A adrenergic receptor ADRA2A 0.0386
6141 Sodium/bile acid cotransporter SLC10A1 0.0369
193 Beta-1 adrenergic receptor ADRB1 0.0361
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0354
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0354
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0351
817 DNA topoisomerase 2-alpha TOP2A 0.0345
6143 Solute carrier family 22 member 7 SLC22A7 0.0345
6147 Solute carrier family 22 member 3 SLC22A3 0.0333
4116 Dihydropteroate synthetase Not Available 0.033
831 D(2) dopamine receptor DRD2 0.0326
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0325
556 Alpha-1A adrenergic receptor ADRA1A 0.0322
1275 Estrogen sulfotransferase SULT1E1 0.0317
502 5-hydroxytryptamine 2A receptor HTR2A 0.0313
847 Mu-type opioid receptor OPRM1 0.0312
468 Cytochrome P450 4A11 CYP4A11 0.031
118 Organic cation/carnitine transporter 2 SLC22A5 0.0302
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0302
103 Muscarinic acetylcholine receptor M1 CHRM1 0.03
844 Epidermal growth factor receptor EGFR 0.0296
1024 Solute carrier family 22 member 11 SLC22A11 0.0295
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0284
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0277
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0273
563 Thyroid peroxidase TPO 0.0271
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0268
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0267
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0265
4604 Liver carboxylesterase 1 CES1 0.0264
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0264
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0259
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0258
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0257
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0257
731 HIV-1 protease HIV-1 protease 0.0257
1852 Microtubule-associated protein 2 MAP2 0.0256
6031 Cytochrome P450 3A43 CYP3A43 0.0256
467 Delta-type opioid receptor OPRD1 0.0254
6148 Multidrug resistance-associated protein 7 ABCC10 0.0251
3923 Cholinesterase BCHE 0.0247
578 Endothelin-1 receptor EDNRA 0.0247
226 Gonadotropin-releasing hormone receptor GNRHR 0.024
2107 Microtubule-associated protein 1A MAP1A 0.0236
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0236
465 Calmodulin CALM1 0.0235
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0233
992 Protein tyrosine kinase 2 beta PTK2B 0.0232
713 Sodium-dependent dopamine transporter SLC6A3 0.0231
23 D(1A) dopamine receptor DRD1 0.0226
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0225
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0225
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0223
696 Kappa-type opioid receptor OPRK1 0.0222
590 5-hydroxytryptamine 2C receptor HTR2C 0.0222
6137 Multidrug resistance-associated protein 6 ABCC6 0.0221
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.022
6020 Aldehyde oxidase AOX1 0.0218
320 5-hydroxytryptamine 1A receptor HTR1A 0.0218
341 5-hydroxytryptamine 3 receptor HTR3A 0.0216
380 Cytochrome P450 17A1 CYP17A1 0.0212
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0212
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.021
891 Dihydropteroate synthase folP 0.021
5359 Dihydropteroate synthase folP 0.021
7175 Dihydropteroate synthase sulI 0.021
504 Mast/stem cell growth factor receptor KIT 0.0209
6014 Cytochrome P450 2A13 CYP2A13 0.0208
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0206
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0206
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0205
632 Alpha-1B adrenergic receptor ADRA1B 0.0203
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0202
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0198
1353 DNA topoisomerase 1 TOP1 0.0198
3552 DNA topoisomerase 1 topA 0.0198
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0198
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0197
1192 Sulfotransferase 1A1 SULT1A1 0.0194
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0194
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0193
6102 Arylamine N-acetyltransferase 2 NAT2 0.0192
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0192
2183 Fatty acid-binding protein, adipocyte FABP4 0.0191
6258 Protein S100-A7 S100A7 0.0191
29 Tubulin beta-1 chain TUBB1 0.0189
6136 Multidrug resistance-associated protein 5 ABCC5 0.0187
70 Type-1 angiotensin II receptor AGTR1 0.0187
122 P2Y purinoceptor 12 P2RY12 0.0185
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0184
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0182
6182 Cytochrome P450 2J2 CYP2J2 0.018
330 Spermidine synthase SRM 0.0177
3038 Spermidine synthase speE 0.0177
3947 Xanthine dehydrogenase/oxidase XDH 0.0175
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0175
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0175
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0171
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0169
885 5-hydroxytryptamine 1B receptor HTR1B 0.0166
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0166
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0165
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0163
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.016
789 Alpha-1D adrenergic receptor ADRA1D 0.0159
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0159
833 Organic cation/carnitine transporter 1 SLC22A4 0.0158
638 D(3) dopamine receptor DRD3 0.0157
811 Translocator protein TSPO 0.0157
1010 Cytochrome P450 51A1 CYP51A1 0.0156
4120 NADPH--cytochrome P450 reductase POR 0.0156
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0156
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.015
629 Alpha-2B adrenergic receptor ADRA2B 0.015
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.015
725 5-hydroxytryptamine 1D receptor HTR1D 0.0149
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0149
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0146
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0145
482 Glycine receptor subunit alpha-1 GLRA1 0.0145
407 Vascular endothelial growth factor receptor 2 KDR 0.0144
411 Glycine N-methyltransferase GNMT 0.0144
1757 Myeloperoxidase MPO 0.0142
358 Cystathionine beta-synthase CBS 0.0142
6221 Steroid hormone receptor ERR1 ESRRA 0.0142
1178 Adenosine A2a receptor ADORA2A 0.0142
228 Beta platelet-derived growth factor receptor PDGFRB 0.0141
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0141
6044 Serum paraoxonase/lactonase 3 PON3 0.014
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0139
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0137
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0135
267 Plasminogen activator inhibitor 1 SERPINE1 0.0135
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0131
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0131
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.013
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.013
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0129
26 Vascular endothelial growth factor receptor 3 FLT4 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0128
517 Alcohol dehydrogenase 1C ADH1C 0.0125
705 Glutamate receptor 1 GRIA1 0.0124
1656 CYP2B protein CYP2B 0.0124
777 Tumor necrosis factor TNF 0.0124
232 Corticosteroid-binding globulin SERPINA6 0.0123
537 ATP synthase delta chain, mitochondrial ATP5D 0.0123
32 Vascular endothelial growth factor receptor 1 FLT1 0.0123
275 Arachidonate 5-lipoxygenase ALOX5 0.0122
161 Tubulin beta chain TUBB 0.0122
312 Tubulin beta chain TUB2 0.0122
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
594 Thyroxine-binding globulin SERPINA7 0.012
436 5-hydroxytryptamine 2B receptor HTR2B 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0118
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0118
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0118
6085 Fatty acid-binding protein, intestinal FABP2 0.0118
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0118
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0118
474 Acetylcholinesterase ACHE 0.0117
4237 50S ribosomal protein L22 rplV 0.0117
6220 Aryl hydrocarbon receptor AHR 0.0116
1649 Small inducible cytokine A2 CCL2 0.0116
88 Retinoic acid receptor RXR-beta RXRB 0.0115
758 Thyroid hormone receptor alpha THRA 0.0115
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0114
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0114
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0111
2230 Catalase CAT 0.0111
3249 Catalase katA 0.0111
3625 Catalase katA 0.0111
4539 Catalase katA 0.0111
4941 Catalase katB 0.0111
432 D(4) dopamine receptor DRD4 0.0111
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0111
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0111
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0111
365 Dihydrofolate reductase DHFR 0.0111
2381 Dihydrofolate reductase DFR1 0.0111
2833 Dihydrofolate reductase Not Available 0.0111
2931 Dihydrofolate reductase folA 0.0111
3544 Dihydrofolate reductase folA 0.0111
3682 Dihydrofolate reductase folA 0.0111
6642 Dihydrofolate reductase folA 0.0111
6756 Dihydrofolate reductase dfrA 0.0111
16 Adenosine A1 receptor ADORA1 0.0111
68 Cannabinoid receptor 1 CNR1 0.0111
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0109
346 Thyroid hormone receptor beta-1 THRB 0.0109
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0109
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0108
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0108
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0108
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0107
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0107
3957 Adenosine deaminase ADA 0.0107
4238 50S ribosomal protein L4 rplD 0.0106
5578 50S ribosomal protein L4 rplD 0.0106
6173 50S ribosomal protein L4 rplD 0.0106
6219 50S ribosomal protein L4 rplD 0.0106
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0106
6167 Organic solute transporter subunit beta OSTB 0.0106
6166 Organic solute transporter subunit alpha OSTA 0.0106
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
737 Mineralocorticoid receptor NR3C2 0.0104
117 Sterol O-acyltransferase 1 SOAT1 0.0104
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0104
952 Dipeptidyl peptidase 4 DPP4 0.0104
153 Dopamine beta-hydroxylase DBH 0.0104
4773 Deoxycytidine kinase DCK 0.0104
94 5-hydroxytryptamine 4 receptor HTR4 0.0103
24 Thymidylate synthase TMP1 0.0103
359 Thymidylate synthase TYMS 0.0103
2626 Thymidylate synthase thyA 0.0103
2729 Thymidylate synthase thyA 0.0103
5352 Thymidylate synthase THYA 0.0103
469 Annexin A1 ANXA1 0.0103
780 Retinoic acid receptor RXR-gamma RXRG 0.0103
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0102
738 Monocarboxylate transporter 1 SLC16A1 0.0102
6149 Solute carrier family 22 member 10 SLC22A10 0.0099
295 Carbonic anhydrase 1 CA1 0.0099
2391 Ferrochelatase hemH 0.0097
6502 Ferrochelatase DKFZp686P18130 0.0097
1591 Ferrochelatase, mitochondrial FECH 0.0097
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0097
2539 Tubulin alpha-1 chain TUBA4A 0.0096
33 Cystine/glutamate transporter SLC7A11 0.0096
251 Alcohol dehydrogenase 1A ADH1A 0.0095
444 Alcohol dehydrogenase 1B ADH1B 0.0095
716 5-hydroxytryptamine 7 receptor HTR7 0.0095
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0095
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0094
904 Glutathione S-transferase P GSTP1 0.0094
381 Prolactin receptor PRLR 0.0093
84 Nuclear receptor 0B1 NR0B1 0.0093
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0093
3587 Gastrotropin FABP6 0.0093
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0092
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0091
378 Alpha-2C adrenergic receptor ADRA2C 0.0091
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.009
3917 Methylenetetrahydrofolate reductase MTHFR 0.009
3932 Glutathione S-transferase A2 GSTA2 0.0089
162 Retinoic acid receptor gamma-1 RARG 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
273 Apoptosis regulator Bcl-2 BCL2 0.0088
908 Glutathione S-transferase theta-1 GSTT1 0.0087
592 Carbonic anhydrase 4 CA4 0.0086
518 Peroxidase/catalase T katG 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
106 Cannabinoid receptor 2 CNR2 0.0086
571 Melatonin receptor type 1A MTNR1A 0.0085
362 Melatonin receptor type 1B MTNR1B 0.0085
5787 Angiopoietin-1 receptor TEK 0.0085
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
5923 Microtubule-associated protein tau MAPT 0.0085
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0085
5924 Microtubule-associated protein 4 MAP4 0.0085
6493 Cytochrome c oxidase subunit 6C COX6C 0.0085
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0085
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0085
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0085
6559 Cytochrome c oxidase subunit 2 ctaC 0.0085
6669 Cytochrome c oxidase subunit 2 ctaC 0.0085
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0085
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0085
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0085
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0085
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0085
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0084
6558 Cytochrome c oxidase subunit 1 ctaD 0.0084
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0084
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0084
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0084
124 Histamine H2 receptor HRH2 0.0084
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0083
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
921 Glutamate receptor 2 GRIA2 0.0083
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0082
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0082
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0081
634 Squalene monooxygenase SQLE 0.008
7196 Squalene monooxygenase ERG1 0.008
165 FL cytokine receptor FLT3 0.008
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.008
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.008
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
459 Retinoic acid receptor RXR-alpha RXRA 0.0079
7 Nitric oxide synthase, inducible NOS2 0.0079
5934 Cytochrome P450 26A1 CYP26A1 0.0078
2540 Choloylglycine hydrolase cbh 0.0078
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0078
239 Coagulation factor X F10 0.0077
823 Fibroblast growth factor receptor 2 FGFR2 0.0077
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0076
163 D(1B) dopamine receptor DRD5 0.0076
6146 High affinity copper uptake protein 1 SLC31A1 0.0075
229 Retinoic acid receptor beta RARB 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4122 Histone deacetylase 2 HDAC2 0.0074
1541 Metalloproteinase mmp20 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
477 DNA topoisomerase 4 subunit A parC 0.0074
886 DNA topoisomerase 4 subunit A parC 0.0074
6226 DNA topoisomerase 4 subunit A parC 0.0074
6501 Fatty acid-binding protein, liver FABP1 0.0074
730 Retinoic acid receptor alpha RARA 0.0073
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0073
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0073
183 Vascular endothelial growth factor A VEGFA 0.0073
6174 50S ribosomal protein L32 rpmF 0.0073
199 Monocarboxylate transporter 8 SLC16A2 0.0073
404 DNA gyrase subunit A gyrA 0.0072
6224 DNA gyrase subunit A gyrA 0.0072
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0072
3856 Fibroblast growth factor receptor 3 FGFR3 0.0071
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1050 Bile salt sulfotransferase SULT2A1 0.0071
49 Endothelin B receptor EDNRB 0.0069
511 5-hydroxytryptamine 1F receptor HTR1F 0.0069
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0069
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0069
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0068
1650 Heme carrier protein 1 SLC46A1 0.0068
814 Ryanodine receptor 1 RYR1 0.0067
3830 Calreticulin CALR 0.0067
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0067
427 Substance-P receptor TACR1 0.0067
528 5-hydroxytryptamine 1E receptor HTR1E 0.0066
144 Hemoglobin subunit alpha HBA1 0.0066
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0066
1618 High affinity nerve growth factor receptor NTRK1 0.0065
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
357 Carbonic anhydrase 2 CA2 0.0065
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0064
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4210 Toll-like receptor 4 TLR4 0.0063
133 Dihydropterate synthase sulI 0.0063
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0063
4217 Telomerase reverse transcriptase TERT 0.0062
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0062
6126 Carbonic anhydrase 7 CA7 0.0062
6035 Nuclear receptor ROR-beta RORB 0.0062
6034 Hydroxyindole O-methyltransferase ASMT 0.0062
6036 Eosinophil peroxidase EPX 0.0062
4203 Histamine N-methyltransferase HNMT 0.0061
1291 cAMP response element-binding protein CREB1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
6500 Phospholipase A2 PLA2G1B 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
2298 Cytochrome P450-cam camC 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
319 Opioid receptor, sigma 1 OPRS1 0.0059
6163 Copper-transporting ATPase 2 ATP7B 0.0059
6165 Copper-transporting ATPase 1 ATP7A 0.0059
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
54 Prothrombin F2 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
284 DNA-directed RNA polymerase beta chain rpoB 0.0057
5773 DNA-directed RNA polymerase beta chain rpoB 0.0057
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0057
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0057
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0057
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0057
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0057
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0057
4192 DNA topoisomerase 2-beta TOP2B 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
896 Glutathione S-transferase Mu 1 GSTM1 0.0056
723 Cytosolic phospholipase A2 PLA2G4A 0.0056
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0056
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0056
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0056
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0056
2236 Casein kinase II subunit alpha CSNK2A1 0.0056
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0056
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0055
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0055
1629 Transcription factor AP-1 JUN 0.0054
765 Indoleamine 2,3-dioxygenase IDO1 0.0054
4226 Uridine phosphorylase 2 UPP2 0.0052
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
293 Gamma-glutamyl hydrolase GGH 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0051
3639 Thymidine phosphorylase deoA 0.0051
3936 Thymidine phosphorylase TYMP 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
936 Ephrin type-A receptor 2 EPHA2 0.005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.005
1256 5-hydroxytryptamine 6 receptor HTR6 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
3937 Fatty-acid amide hydrolase FAAH 0.0049
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0049
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0049
2320 Thymidine kinase, cytosolic TK1 0.0049
856 Vitamin D3 receptor VDR 0.0049
2981 Phospholipase A2, membrane associated PLA2G2A 0.0049
4225 Uridine phosphorylase 1 UPP1 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
6766 O-GlcNAcase BT_4395 BT_4395 0.0048
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0047
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
6151 Monocarboxylate transporter 10 SLC16A10 0.0046
6824 Tyrosine-protein kinase Lyn LYN 0.0046
1648 Elastin ELN 0.0046
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0046
131 Synaptic vesicular amine transporter SLC18A2 0.0046
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
718 Folate receptor gamma FOLR3 0.0045
804 Mitochondrial folate transporter/carrier SLC25A32 0.0045
299 Folate receptor beta FOLR2 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
413 Amidophosphoribosyltransferase PPAT 0.0045
2515 Amidophosphoribosyltransferase purF 0.0045
3714 Amidophosphoribosyltransferase purF 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0044
130 Prostacyclin synthase PTGIS 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0042
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
6432 Transporter snf 0.0041
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3808 Dihydropteroate synthase 2 folP2 0.0041
3601 Dihydropteroate synthase 1 folP1 0.0041
3807 Dihydropteroate synthase 1 folP1 0.0041
976 Platelet glycoprotein IX GP9 0.004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0039
291 Nitric-oxide synthase, endothelial NOS3 0.0039
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0039
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0038
164 Histamine H4 receptor HRH4 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6043 Putative G-protein coupled receptor 44 GPR44 0.0037
2216 Fibroblast growth factor receptor 4 FGFR4 0.0037
2782 Complement C1s subcomponent C1S 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
174 Sigma 1-type opioid receptor SIGMAR1 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
3404 Exotoxin A eta 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
4311 tRNA TRDMT1 0.0035
4325 tRNA trmD 0.0035
4328 tRNA trmD 0.0035
939 50S ribosomal protein L3 rplC 0.0035
5798 Mitogen-activated protein kinase 11 MAPK11 0.0035
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
719 Retinoic acid receptor responder protein 1 RARRES1 0.0034
770 Retinoic acid-induced protein 3 GPRC5A 0.0034
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0034
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0034
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0034
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0033
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0033
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0033
2207 Rhodopsin RHO 0.0033
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
400 Coagulation factor IX F9 0.0033
5461 Coagulation factor IX F9 0.0033
5880 Thrombopoietin receptor MPL 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0032
489 Monocarboxylate transporter 2 SLC16A7 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
3086 Plasmepsin-2 Not Available 0.0031
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0031
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0031
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0031
1268 Neuropeptide S receptor NPSR1 0.0031
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0031
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.003
1374 Natriuretic peptides B NPPB 0.003
604 Vitamin K-dependent protein Z PROZ 0.003
702 UMP-CMP kinase CMPK1 0.003
569 Retinal dehydrogenase 2 ALDH1A2 0.003
1827 Gap junction alpha-1 protein GJA1 0.003
1908 Vascular cell adhesion protein 1 VCAM1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0029
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0029
6459 Glycodelin PAEP 0.0028
2290 ADP-ribosyl cyclase 2 BST1 0.0028
611 Retinal dehydrogenase 1 ALDH1A1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
268 Adenosine A2b receptor ADORA2B 0.0028
1253 Interferon gamma IFNG 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
422 Vitamin K-dependent protein C PROC 0.0028
1245 Vitamin K-dependent protein S PROS1 0.0028
6073 Potassium channel subfamily K member 9 KCNK9 0.0028
6072 Potassium channel subfamily K member 3 KCNK3 0.0028
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
1630 Integrin beta-2 ITGB2 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
1063 Signal transducer and activator of transcription 5B STAT5B 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
1360 Sphingomyelin phosphodiesterase SMPD1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0027
760 Fibroblast growth factor 1 FGF1 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0027
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0027
605 Fumarate reductase flavoprotein subunit frdA 0.0027
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0027
3673 Fumarate reductase flavoprotein subunit fccA 0.0027
4912 Fumarate reductase flavoprotein subunit ifcA 0.0027
6549 Fumarate reductase flavoprotein subunit frdA 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0026
1039 Histone deacetylase 9 HDAC9 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1864 RET proto-oncogene RET 0.0026
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0026
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0026
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0026
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
798 Osteocalcin BGLAP 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1992 Vitamin D-binding protein GC 0.0022
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
572 Integrin alpha-L ITGAL 0.0021
3221 Cytochrome c4 cc4 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
369 Coagulation factor VII F7 0.002
5626 Nucleoside diphosphate kinase B NME2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
820 Glycine receptor subunit alpha-2 GLRA2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
1058 Cell division protein kinase 5 CDK5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
2021 Thrombomodulin THBD 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6218 Pannexin-1 PANX1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
5294 Nucleoside diphosphate kinase A NME1 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0016
173 Toll-like receptor 7 TLR7 0.0016
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0016
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6168 Solute carrier family 22 member 16 SLC22A16 0.0016
3233 Bile acid receptor NR1H4 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
5818 Folate receptor alpha FOLR1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1867 Major prion protein PRNP 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
1507 Cytochrome c CYCS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
693 Hemoglobin subunit beta HBB 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
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