DT-Web

DB00254 - Doxycycline


Identification
Name Doxycycline
Accession Number DB00254 (APRD00597)
Type small molecule
Description A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 444.4346
Groups approved
Monoisotopic Weight 444.153265754
Pharmacology
Indication Doxycycline is indicated for use in respiratory tract infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, Legionella spp., or Klebsiella spp. It is also used for prophylaxis of malaria. Doxycycline is indicated for a variety of bacterial infections, from Mycobacterium fortuitum and M. marinum, to susceptible E. coli and Brucella spp. It can be used as an alternative to treating plague, tetanus, Campylobacter fetus
Mechanism of action Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis. Doxycycline prevents the normal function of the apicoplast of Plasmodium falciparum, a malaria causing organism.
Absorption Completely absorbed following oral administration.
Protein binding >90%
Biotransformation Hepatic
Route of elimination They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.
Toxicity Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The tetracycline, doxycycline, may increase the anticoagulant effect of acenocoumarol.
Acitretin Increased risk of intracranial hypertension
Aluminium Formation of non-absorbable complexes
Amobarbital The anticonvulsant, amobarbital, decreases the effect of doxycycline.
Amoxicillin Possible antagonism of action
Ampicillin Possible antagonism of action
Anisindione The tetracycline, doxycycline, may increase the anticoagulant effect of anisindione.
Aprobarbital The anticonvulsant, aprobarbital, decreases the effect of doxycycline.
Attapulgite Formation of non-absorbable complexes
Azlocillin Possible antagonism of action
Aztreonam Possible antagonism of action
Bacampicillin Possible antagonism of action
Bexarotene Tetracycline derivatives like doxycycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Butabarbital The anticonvulsant, butabarbital, decreases the effect of doxycycline.
Butalbital The anticonvulsant, butalbital, decreases the effect of doxycycline.
Butethal The anticonvulsant, butethal, decreases the effect of doxycycline.
Calcium Formation of non-absorbable complexes
Calcium Acetate Calcium salts such as calcium acetate may decrease the serum concentration of tetracycline derivatives such as doxycycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Calcium Chloride Calcium salts such as calcium chloride may decrease the serum concentration of tetracycline derivatives such as doxycycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Carbamazepine The anticonvulsant, carbamazepine, may decrease the therapeutic effect of doxycycline.
Carbenicillin Possible antagonism of action
Clavulanate Possible antagonism of action
Cloxacillin Possible antagonism of action
Colesevelam Bile acid sequestrants such as colesevelam may decrease the absorption of Tetracycline Derivatives. Monitor for decreased therapeutic effects of tetracycline derivatives if coadministered with a bile acid sequestrant. If these agents are used concomitantly, separate doses 2 or more hours to minimize the interaction. The manufacturer of colesevelam suggests that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclacillin Possible antagonism of action
Dicloxacillin Possible antagonism of action
Dicumarol The tetracycline, doxycycline, may increase the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate The anticonvulsant, dihydroquinidine barbiturate, decreases the effect of doxycycline.
Ethinyl Estradiol Doxycycline may decrease the contraceptive effect of ethinyl estradiol.
Ethotoin The anticonvulsant, ethotoin, decreases the effect of doxycycline.
Etretinate Increased risk of intracranial hypertension
Flucloxacillin Possible antagonism of action
Fosphenytoin The anticonvulsant, fosphenytoin, decreases the effect of doxycycline.
Heptabarbital The anticonvulsant, heptabarbital, decreases the effect of doxycycline.
Hetacillin Possible antagonism of action
Hexobarbital The anticonvulsant, hexobarbital, decreases the effect of doxycycline.
Iron Formation of non-absorbable complexes
Iron Dextran Formation of non-absorbable complexes
Isotretinoin Increased risk of intracranial hypertension
Magnesium Formation of non-absorbable complexes
Magnesium oxide Formation of non-absorbable complexes
Mephenytoin The anticonvulsant, mephenytoin, decreases the effect of doxycycline.
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methohexital The anticonvulsant, methohexital, decreases the effect of doxycycline.
Methotrexate The tetracycline, doxycycline, may increase methotrexate toxicity.
Methylphenobarbital The anticonvulsant, methylphenobarbital, decreases the effect of doxycycline.
Meticillin Possible antagonism of action
Mezlocillin Possible antagonism of action
Nafcillin Possible antagonism of action
Oxacillin Possible antagonism of action
Penicillin G Possible antagonism of action
Penicillin V Possible antagonism of action
Pentobarbital The anticonvulsant, pentobarbital, decreases the effect of doxycycline.
Phenobarbital The anticonvulsant, phenobarbital, may decrease the therapeutic effect of doxycycline.
Phenytoin The anticonvulsant, phenytoin, may decrease the effect of doxycycline.
Piperacillin Possible antagonism of action
Pivampicillin Possible antagonism of action
Pivmecillinam Possible antagonism of action
Primidone The anticonvulsant, primidone, decreases the effect of doxycycline.
Quinidine barbiturate The anticonvulsant, quinidine barbiturate, decreases the effect of doxycycline.
Rifabutin The rifamycin decreases the effect of doxycycline
Rifampin The rifamycin decreases the effect of doxycycline
Secobarbital The anticonvulsant , secobarbital, decreases the effect of doxycycline.
Talbutal The anticonvulsant, talbutal, decreases the effect of doxycycline.
Tamsulosin Doxycycline, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Doxycycline is initiated, discontinued, or dose changed.
Tazobactam Possible antagonism of action
Thiopental Thiopental may decrease the serum levels of Doxycycline. A reduction in antimicrobial effects may occur. An alternative antibiotic may be considered.
Ticarcillin Doxycycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Doxycycline.
Tolterodine Doxycycline may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tretinoin Doxycycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Warfarin The tetracycline, doxycycline, may increase the anticoagulant effect of warfarin.
Zinc Formation of non-absorbable complexes
Food Interactions
  • Avoid alcohol.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with a full glass of water Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Targets


30S ribosomal protein S9
Name 30S ribosomal protein S9
Gene Name rpsI
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. Epub 2010 Jun 30. - Pubmed
DTHybrid score 1.1158
30S ribosomal protein S4
Name 30S ribosomal protein S4
Gene Name rpsD
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. Epub 2010 Jun 30. - Pubmed
DTHybrid score 1.0365
16S rRNA
Name 16S rRNA
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Pringle M, Fellstrom C, Johansson KE: Decreased susceptibility to doxycycline associated with a 16S rRNA gene mutation in Brachyspira hyodysenteriae. Vet Microbiol. 2007 Jul 20;123(1-3):245-8. Epub 2007 Feb 25. - Pubmed
  • Kumar S, Kutlin A, Roblin P, Kohlhoff S, Bodetti T, Timms P, Hammerschlag MR: Isolation and antimicrobial susceptibilities of Chlamydial isolates from Western barred bandicoots. J Clin Microbiol. 2007 Feb;45(2):392-4. Epub 2006 Nov 22. - Pubmed
  • Ross JI, Eady EA, Cove JH, Cunliffe WJ: 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob Agents Chemother. 1998 Jul;42(7):1702-5. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Zhao XJ, Ishizaki T: A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):272-8. - Pubmed
DTHybrid score 0.3394

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.4649
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.3952
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.3324

Predictions


Id Partner name Gene Name Score
6719 30S ribosomal protein S9 rpsI 1.1158
6725 30S ribosomal protein S9 rpsI 1.1158
6714 30S ribosomal protein S4 rpsD 1.0365
6143 Solute carrier family 22 member 7 SLC22A7 0.1787
4757 Cytochrome P450 2C9 CYP2C9 0.0919
587 Serum albumin ALB 0.0897
1588 Multidrug resistance protein 1 ABCB1 0.0894
4119 Cytochrome P450 2D6 CYP2D6 0.0701
6016 Cytochrome P450 2C19 CYP2C19 0.0696
4924 Cytochrome P450 2C8 CYP2C8 0.0672
6209 30S ribosomal protein S19 rpsS 0.0638
6712 30S ribosomal protein S19 rpsS 0.0638
6726 30S ribosomal protein S19 rpsS 0.0638
6207 30S ribosomal protein S14 rpsN 0.0638
4200 Cytochrome P450 1A2 CYP1A2 0.0637
4118 Cytochrome P450 3A5 CYP3A5 0.0628
20 Prostaglandin G/H synthase 1 PTGS1 0.0614
290 Prostaglandin G/H synthase 2 PTGS2 0.0608
6208 30S ribosomal protein S13 rpsM 0.0567
6706 30S ribosomal protein S13 rpsM 0.0567
118 Organic cation/carnitine transporter 2 SLC22A5 0.0545
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0523
2164 Multidrug resistance-associated protein 4 ABCC4 0.0514
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0512
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.047
1654 Interleukin-1 beta IL1B 0.0466
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0451
6107 Cytochrome P450 3A7 CYP3A7 0.0412
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0381
494 Caspase-1 CASP1 0.0372
308 30S ribosomal protein S12 rpsL 0.037
6704 30S ribosomal protein S12 rpsL 0.037
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0369
183 Vascular endothelial growth factor A VEGFA 0.0367
6144 Solute carrier family 22 member 2 SLC22A2 0.0365
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0357
6013 Cytochrome P450 2E1 CYP2E1 0.0352
862 Multidrug resistance-associated protein 1 ABCC1 0.0351
275 Arachidonate 5-lipoxygenase ALOX5 0.0349
1507 Cytochrome c CYCS 0.0344
6145 Solute carrier family 22 member 1 SLC22A1 0.0341
6030 Cytochrome P450 2B6 CYP2B6 0.034
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0321
65 Matrix metalloproteinase-9 Not Available 0.0318
2077 Caspase-3 CASP3 0.0298
6024 Cytochrome P450 1A1 CYP1A1 0.0298
633 Penicillin-binding proteins 1A/1B pbpA 0.0297
776 Bile salt export pump ABCB11 0.0282
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0266
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0264
738 Monocarboxylate transporter 1 SLC16A1 0.0264
645 Penicillin-binding protein 1A mrcA 0.0249
5805 Penicillin-binding protein 1A ponA 0.0249
6185 Penicillin-binding protein 1A mrcA 0.0249
6799 Penicillin-binding protein 1A pbpA 0.0249
438 Taste receptor type 1 member 2 TAS1R2 0.0248
833 Organic cation/carnitine transporter 1 SLC22A4 0.0246
338 DNA polymerase UL30 0.0228
379 DNA polymerase UL54 0.0228
697 DNA polymerase ORF28 0.0228
2482 DNA polymerase 43 0.0228
4104 DNA polymerase BALF5 0.0228
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
543 Penicillin-binding protein 1B mrcB 0.0221
6186 Penicillin-binding protein 1B ponB 0.0221
6822 Penicillin-binding protein 1b pbp1b 0.0221
6844 Penicillin-binding protein 1b pbp1b 0.0221
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.022
5718 Cytochrome P450 2A6 CYP2A6 0.0216
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0212
6141 Sodium/bile acid cotransporter SLC10A1 0.0212
6136 Multidrug resistance-associated protein 5 ABCC5 0.0206
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.02
2016 Dipeptidase 1 DPEP1 0.0197
357 Carbonic anhydrase 2 CA2 0.0194
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
3811 Cytochrome P450 19A1 CYP19A1 0.0192
592 Carbonic anhydrase 4 CA4 0.0191
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0188
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0187
5353 Glutamate decarboxylase alpha gadA 0.0183
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0181
295 Carbonic anhydrase 1 CA1 0.0176
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0173
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
558 Solute carrier family 12 member 1 SLC12A1 0.0166
871 Glucocorticoid receptor NR3C1 0.0163
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
6149 Solute carrier family 22 member 10 SLC22A10 0.0159
6147 Solute carrier family 22 member 3 SLC22A3 0.0159
492 Histamine H1 receptor HRH1 0.0158
404 DNA gyrase subunit A gyrA 0.0158
6224 DNA gyrase subunit A gyrA 0.0158
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0154
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0151
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
136 Estrogen receptor ESR1 0.0148
1867 Major prion protein PRNP 0.0147
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6106 Cytochrome P450 2C18 CYP2C18 0.014
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
115 Penicillin-binding protein 2 mrdA 0.0138
6069 Penicillin-binding protein 2 mrdA 0.0138
6118 Penicillin-binding protein 2 penA 0.0138
6187 Penicillin-binding protein 2 pbpA 0.0138
6686 Penicillin-binding protein 2 pbp2 0.0138
6939 Penicillin-binding protein 2 mrdA 0.0138
7163 Penicillin-binding protein 2 pbpA 0.0138
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0137
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0133
6020 Aldehyde oxidase AOX1 0.0132
130 Prostacyclin synthase PTGIS 0.0131
6148 Multidrug resistance-associated protein 7 ABCC10 0.013
1 Peptidoglycan synthetase ftsI ftsI 0.0129
4155 Peptidoglycan synthetase ftsI ftsI 0.0129
5626 Nucleoside diphosphate kinase B NME2 0.0127
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0127
124 Histamine H2 receptor HRH2 0.0125
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6167 Organic solute transporter subunit beta OSTB 0.0117
6166 Organic solute transporter subunit alpha OSTA 0.0117
6126 Carbonic anhydrase 7 CA7 0.0115
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
723 Cytosolic phospholipase A2 PLA2G4A 0.0111
3426 Glutamine synthetase glnA 0.011
3987 Glutamine synthetase GLUL 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0109
3947 Xanthine dehydrogenase/oxidase XDH 0.0107
6033 High affinity interleukin-8 receptor A CXCR1 0.0104
373 Transthyretin TTR 0.0104
2320 Thymidine kinase, cytosolic TK1 0.0103
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0103
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0102
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
527 Prostacyclin receptor PTGIR 0.0102
540 Sodium-dependent noradrenaline transporter SLC6A2 0.01
672 Prostaglandin F2-alpha receptor PTGFR 0.0099
1405 Thiopurine S-methyltransferase TPMT 0.0097
4604 Liver carboxylesterase 1 CES1 0.0096
867 Penicillin-binding protein 3 pbpC 0.0094
6119 Penicillin-binding protein 3 pbp3 0.0094
7154 Penicillin-binding protein 3 pbp3 0.0094
7157 Penicillin-binding protein 3 LMHCC_2184 0.0094
7162 Penicillin-binding protein 3 pbpB 0.0094
7172 Penicillin-binding protein 3 pbp3 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0092
1898 Cytochrome P450 1B1 CYP1B1 0.0091
556 Alpha-1A adrenergic receptor ADRA1A 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
824 Sodium-dependent serotonin transporter SLC6A4 0.0088
6043 Putative G-protein coupled receptor 44 GPR44 0.0088
731 HIV-1 protease HIV-1 protease 0.0087
53 Solute carrier family 12 member 5 SLC12A5 0.0085
663 Solute carrier family 12 member 4 SLC12A4 0.0085
847 Mu-type opioid receptor OPRM1 0.0084
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
756 Sex hormone-binding globulin SHBG 0.0083
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0083
477 DNA topoisomerase 4 subunit A parC 0.0083
886 DNA topoisomerase 4 subunit A parC 0.0083
6226 DNA topoisomerase 4 subunit A parC 0.0083
502 5-hydroxytryptamine 2A receptor HTR2A 0.0082
232 Corticosteroid-binding globulin SERPINA6 0.008
817 DNA topoisomerase 2-alpha TOP2A 0.008
310 Solute carrier family 12 member 2 SLC12A2 0.008
318 Alpha-2A adrenergic receptor ADRA2A 0.008
146 Androgen receptor AR 0.008
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0078
6137 Multidrug resistance-associated protein 6 ABCC6 0.0077
320 5-hydroxytryptamine 1A receptor HTR1A 0.0075
831 D(2) dopamine receptor DRD2 0.0075
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0072
6131 Carbonic anhydrase 14 CA14 0.0071
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0071
4217 Telomerase reverse transcriptase TERT 0.0071
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.007
467 Delta-type opioid receptor OPRD1 0.007
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0069
260 Cytochrome P450 51 ERG11 0.0069
761 Cytochrome P450 51 ERG11 0.0069
3163 Cytochrome P450 51 cyp51 0.0069
952 Dipeptidyl peptidase 4 DPP4 0.0069
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0068
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0068
3760 Penicillin-binding protein 5 precursor dacA 0.0068
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0068
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0067
3917 Methylenetetrahydrofolate reductase MTHFR 0.0066
6031 Cytochrome P450 3A43 CYP3A43 0.0066
6122 Carbonic anhydrase 3 CA3 0.0066
244 Angiotensin-converting enzyme ACE 0.0066
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0066
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0066
24 Thymidylate synthase TMP1 0.0066
359 Thymidylate synthase TYMS 0.0066
2626 Thymidylate synthase thyA 0.0066
2729 Thymidylate synthase thyA 0.0066
5352 Thymidylate synthase THYA 0.0066
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0065
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
6085 Fatty acid-binding protein, intestinal FABP2 0.0064
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0064
614 Progesterone receptor PGR 0.0062
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0061
819 Penicillin-binding protein 4 dacB 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
1757 Myeloperoxidase MPO 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0059
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0059
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0059
2981 Phospholipase A2, membrane associated PLA2G2A 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0058
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0058
632 Alpha-1B adrenergic receptor ADRA1B 0.0057
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0057
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0057
3007 Carbonic anhydrase 12 CA12 0.0057
4205 Carbonic anhydrase 9 CA9 0.0057
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0057
23 D(1A) dopamine receptor DRD1 0.0057
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0056
2021 Thrombomodulin THBD 0.0055
696 Kappa-type opioid receptor OPRK1 0.0055
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0055
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0055
4760 Mll3241 protein mll3241 0.0055
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
293 Gamma-glutamyl hydrolase GGH 0.0054
3932 Glutathione S-transferase A2 GSTA2 0.0053
590 5-hydroxytryptamine 2C receptor HTR2C 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
341 5-hydroxytryptamine 3 receptor HTR3A 0.0053
3923 Cholinesterase BCHE 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.005
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
6218 Pannexin-1 PANX1 0.0048
6014 Cytochrome P450 2A13 CYP2A13 0.0048
766 Beta-2 adrenergic receptor ADRB2 0.0048
3941 Amine oxidase [flavin-containing] A MAOA 0.0048
1650 Heme carrier protein 1 SLC46A1 0.0048
789 Alpha-1D adrenergic receptor ADRA1D 0.0047
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0047
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0046
713 Sodium-dependent dopamine transporter SLC6A3 0.0046
629 Alpha-2B adrenergic receptor ADRA2B 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0043
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0043
273 Apoptosis regulator Bcl-2 BCL2 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0042
885 5-hydroxytryptamine 1B receptor HTR1B 0.0042
378 Alpha-2C adrenergic receptor ADRA2C 0.0042
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
408 Riboflavin kinase RFK 0.0041
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0041
5818 Folate receptor alpha FOLR1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6042 Prostaglandin reductase 2 PTGR2 0.0041
638 D(3) dopamine receptor DRD3 0.0041
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.004
29 Tubulin beta-1 chain TUBB1 0.004
725 5-hydroxytryptamine 1D receptor HTR1D 0.004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.004
869 Estrogen receptor beta ESR2 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.004
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0039
5482 Sialidase-2 NEU2 0.0039
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0039
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0039
634 Squalene monooxygenase SQLE 0.0039
7196 Squalene monooxygenase ERG1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
1792 Tissue-type plasminogen activator PLAT 0.0038
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0038
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0036
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0036
6182 Cytochrome P450 2J2 CYP2J2 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0035
856 Vitamin D3 receptor VDR 0.0035
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0035
997 Protein kinase C beta type PRKCB 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4773 Deoxycytidine kinase DCK 0.0035
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0035
811 Translocator protein TSPO 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
193 Beta-1 adrenergic receptor ADRB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
3810 Catechol O-methyltransferase COMT 0.0034
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
474 Acetylcholinesterase ACHE 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
70 Type-1 angiotensin II receptor AGTR1 0.0033
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0033
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0033
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0033
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0032
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0032
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0032
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0032
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0032
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0032
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0032
380 Cytochrome P450 17A1 CYP17A1 0.0032
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0031
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0031
432 D(4) dopamine receptor DRD4 0.0031
1313 Lactoylglutathione lyase GLO1 0.0031
489 Monocarboxylate transporter 2 SLC16A7 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
465 Calmodulin CALM1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.003
716 5-hydroxytryptamine 7 receptor HTR7 0.003
654 Flavin reductase BLVRB 0.0029
2236 Casein kinase II subunit alpha CSNK2A1 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0029
3587 Gastrotropin FABP6 0.0028
571 Melatonin receptor type 1A MTNR1A 0.0028
362 Melatonin receptor type 1B MTNR1B 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
6102 Arylamine N-acetyltransferase 2 NAT2 0.0028
1196 Complement decay-accelerating factor CD55 0.0027
436 5-hydroxytryptamine 2B receptor HTR2B 0.0027
5126 Arginase rocF 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1050 Bile salt sulfotransferase SULT2A1 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
49 Endothelin B receptor EDNRB 0.0026
1039 Histone deacetylase 9 HDAC9 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2808 Chloramphenicol acetyltransferase 3 cat3 0.0024
1714 Mitogen-activated protein kinase 3 MAPK3 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0024
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6168 Solute carrier family 22 member 16 SLC22A16 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0023
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
777 Tumor necrosis factor TNF 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
737 Mineralocorticoid receptor NR3C2 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0022
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0022
2417 Chloramphenicol acetyltransferase cat 0.0022
3278 Chloramphenicol acetyltransferase cat 0.0022
2810 Dr hemagglutinin structural subunit draA 0.0022
6220 Aryl hydrocarbon receptor AHR 0.0022
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1656 CYP2B protein CYP2B 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
163 D(1B) dopamine receptor DRD5 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
33 Cystine/glutamate transporter SLC7A11 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
4120 NADPH--cytochrome P450 reductase POR 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
613 Atrial natriuretic peptide receptor A NPR1 0.0017
199 Monocarboxylate transporter 8 SLC16A2 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0016
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
228 Beta platelet-derived growth factor receptor PDGFRB 0.0016
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
1192 Sulfotransferase 1A1 SULT1A1 0.0016
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
3233 Bile acid receptor NR1H4 0.0015
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
3939 Amine oxidase [flavin-containing] B MAOB 0.0015
427 Substance-P receptor TACR1 0.0015
1629 Transcription factor AP-1 JUN 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1541 Metalloproteinase mmp20 0.0014
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
6645 D-amino-acid oxidase DAO 0.0014
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0014
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
822 Aldose reductase AKR1B1 0.0014
3809 Estrogen-related receptor gamma ESRRG 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
4122 Histone deacetylase 2 HDAC2 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
16 Adenosine A1 receptor ADORA1 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
1295 Fatty acid synthase FASN 0.0012
904 Glutathione S-transferase P GSTP1 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
1178 Adenosine A2a receptor ADORA2A 0.0011
239 Coagulation factor X F10 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
921 Glutamate receptor 2 GRIA2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
54 Prothrombin F2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0009
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
517 Alcohol dehydrogenase 1C ADH1C 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
2232 Interleukin-5 IL5 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6432 Transporter snf 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
469 Annexin A1 ANXA1 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
164 Histamine H4 receptor HRH4 0.0007
125 DNA polymerase beta POLB 0.0007
1618 High affinity nerve growth factor receptor NTRK1 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3937 Fatty-acid amide hydrolase FAAH 0.0006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1341 Histamine H3 receptor HRH3 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
823 Fibroblast growth factor receptor 2 FGFR2 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
7 Nitric oxide synthase, inducible NOS2 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
319 Opioid receptor, sigma 1 OPRS1 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
976 Platelet glycoprotein IX GP9 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
174 Sigma 1-type opioid receptor SIGMAR1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
5934 Cytochrome P450 26A1 CYP26A1 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
3957 Adenosine deaminase ADA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
2207 Rhodopsin RHO 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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