DT-Web

DB01060 - Amoxicillin


Identification
Name Amoxicillin
Accession Number DB01060 (APRD00248)
Type small molecule
Description A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 365.404
Groups approved
Monoisotopic Weight 365.104541423
Pharmacology
Indication For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Mechanism of action Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.
Absorption Rapidly absorbed after oral administration.
Protein binding In blood serum, amoxicillin is approximately 20% protein-bound
Biotransformation Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins
Route of elimination Most of the amoxicillin is excreted unchanged in the urine; its excretion can be delayed by concurrent administration of probenecid.
Toxicity Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline Possible antagonism of action
Methotrexate The penicillin increases the effect and toxicity of methotrexate
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Food Interactions
  • Take without regard to meals.

Targets


Penicillin-binding proteins 1A/1B
Name Penicillin-binding proteins 1A/1B
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Okamoto T, Yoshiyama H, Nakazawa T, Park ID, Chang MW, Yanai H, Okita K, Shirai M: A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori. J Antimicrob Chemother. 2002 Dec;50(6):849-56. - Pubmed
DTHybrid score 0.8579

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1998

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Wenzel U, Gebert I, Weintraut H, Weber WM, Clauss W, Daniel H: Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J Pharmacol Exp Ther. 1996 May;277(2):831-9. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. Epub 2006 Jan 24. - Pubmed
DTHybrid score 0.5909
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
  • Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. Epub 2006 Jan 24. - Pubmed
DTHybrid score 0.5813
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.3499

Predictions


Id Partner name Gene Name Score
244 Angiotensin-converting enzyme ACE 0.1783
4512 Cytochrome P450 3A4 CYP3A4 0.1248
118 Organic cation/carnitine transporter 2 SLC22A5 0.1186
4757 Cytochrome P450 2C9 CYP2C9 0.113
6142 Solute carrier family 22 member 8 SLC22A8 0.1079
587 Serum albumin ALB 0.0823
1 Peptidoglycan synthetase ftsI ftsI 0.0811
4155 Peptidoglycan synthetase ftsI ftsI 0.0811
1588 Multidrug resistance protein 1 ABCB1 0.0767
1024 Solute carrier family 22 member 11 SLC22A11 0.0755
4119 Cytochrome P450 2D6 CYP2D6 0.0741
4200 Cytochrome P450 1A2 CYP1A2 0.0606
4924 Cytochrome P450 2C8 CYP2C8 0.059
645 Penicillin-binding protein 1A mrcA 0.0513
5805 Penicillin-binding protein 1A ponA 0.0513
6185 Penicillin-binding protein 1A mrcA 0.0513
6799 Penicillin-binding protein 1A pbpA 0.0513
20 Prostaglandin G/H synthase 1 PTGS1 0.0496
6143 Solute carrier family 22 member 7 SLC22A7 0.0494
1757 Myeloperoxidase MPO 0.0428
4118 Cytochrome P450 3A5 CYP3A5 0.0418
543 Penicillin-binding protein 1B mrcB 0.0385
6186 Penicillin-binding protein 1B ponB 0.0385
6822 Penicillin-binding protein 1b pbp1b 0.0385
6844 Penicillin-binding protein 1b pbp1b 0.0385
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0384
6067 Penicillin binding protein 2a mecA 0.0376
6030 Cytochrome P450 2B6 CYP2B6 0.0353
1385 Angiotensin-converting enzyme 2 ACE2 0.035
6013 Cytochrome P450 2E1 CYP2E1 0.0346
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.034
290 Prostaglandin G/H synthase 2 PTGS2 0.0311
6107 Cytochrome P450 3A7 CYP3A7 0.0299
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0294
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0286
159 Penicillin-binding protein 2B penA 0.0277
6121 Penicillin-binding protein 2B penA 0.0277
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0264
4252 Penicillin-binding protein 5 dacA 0.0263
6106 Cytochrome P450 2C18 CYP2C18 0.025
234 Plasminogen PLG 0.0246
2164 Multidrug resistance-associated protein 4 ABCC4 0.0237
115 Penicillin-binding protein 2 mrdA 0.0235
6069 Penicillin-binding protein 2 mrdA 0.0235
6118 Penicillin-binding protein 2 penA 0.0235
6187 Penicillin-binding protein 2 pbpA 0.0235
6686 Penicillin-binding protein 2 pbp2 0.0235
6939 Penicillin-binding protein 2 mrdA 0.0235
7163 Penicillin-binding protein 2 pbpA 0.0235
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0234
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
6024 Cytochrome P450 1A1 CYP1A1 0.0227
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0227
5718 Cytochrome P450 2A6 CYP2A6 0.0225
3923 Cholinesterase BCHE 0.0217
3917 Methylenetetrahydrofolate reductase MTHFR 0.021
338 DNA polymerase UL30 0.0203
379 DNA polymerase UL54 0.0203
697 DNA polymerase ORF28 0.0203
2482 DNA polymerase 43 0.0203
4104 DNA polymerase BALF5 0.0203
738 Monocarboxylate transporter 1 SLC16A1 0.02
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
4604 Liver carboxylesterase 1 CES1 0.0194
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0187
862 Multidrug resistance-associated protein 1 ABCC1 0.0173
2385 Penicillin acylase Not Available 0.0166
332 Beta-lactamase blaZ 0.0166
2478 Beta-lactamase ampC 0.0166
2613 Beta-lactamase ampC 0.0166
2635 Beta-lactamase ampC 0.0166
2700 Beta-lactamase penP 0.0166
5445 Beta-lactamase blaB 0.0166
6019 Beta-lactamase SHV-7 0.0166
6701 Beta-lactamase cphA 0.0166
592 Carbonic anhydrase 4 CA4 0.0165
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0164
819 Penicillin-binding protein 4 dacB 0.0161
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0155
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
6144 Solute carrier family 22 member 2 SLC22A2 0.0147
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0144
295 Carbonic anhydrase 1 CA1 0.0144
6145 Solute carrier family 22 member 1 SLC22A1 0.0143
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
357 Carbonic anhydrase 2 CA2 0.0133
776 Bile salt export pump ABCB11 0.013
492 Histamine H1 receptor HRH1 0.0129
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0129
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0127
509 Thymidine kinase TK 0.0126
570 Thymidine kinase TK 0.0126
2559 Thymidine kinase TK 0.0126
3430 Thymidine kinase tdk 0.0126
3518 Thymidine kinase TK 0.0126
5301 Thymidine kinase tdk 0.0126
5771 Thymidine kinase ORF36 0.0126
7009 Thymidine kinase ORF36 0.0126
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0124
3426 Glutamine synthetase glnA 0.0123
3987 Glutamine synthetase GLUL 0.0123
833 Organic cation/carnitine transporter 1 SLC22A4 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0118
4790 Glycosyltransferase GtfA gtfA 0.011
824 Sodium-dependent serotonin transporter SLC6A4 0.0108
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0107
3760 Penicillin-binding protein 5 precursor dacA 0.0105
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0105
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0103
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0103
867 Penicillin-binding protein 3 pbpC 0.0102
6119 Penicillin-binding protein 3 pbp3 0.0102
7154 Penicillin-binding protein 3 pbp3 0.0102
7157 Penicillin-binding protein 3 LMHCC_2184 0.0102
7162 Penicillin-binding protein 3 pbpB 0.0102
7172 Penicillin-binding protein 3 pbp3 0.0102
3810 Catechol O-methyltransferase COMT 0.0102
556 Alpha-1A adrenergic receptor ADRA1A 0.0101
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0101
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.01
632 Alpha-1B adrenergic receptor ADRA1B 0.0099
318 Alpha-2A adrenergic receptor ADRA2A 0.0098
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0096
6126 Carbonic anhydrase 7 CA7 0.0095
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
260 Cytochrome P450 51 ERG11 0.0092
761 Cytochrome P450 51 ERG11 0.0092
3163 Cytochrome P450 51 cyp51 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
65 Matrix metalloproteinase-9 Not Available 0.0086
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0085
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0081
3941 Amine oxidase [flavin-containing] A MAOA 0.008
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
558 Solute carrier family 12 member 1 SLC12A1 0.0077
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0076
3811 Cytochrome P450 19A1 CYP19A1 0.0074
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0074
707 72 kDa type IV collagenase MMP2 0.0073
6136 Multidrug resistance-associated protein 5 ABCC5 0.0073
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0072
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0072
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
817 DNA topoisomerase 2-alpha TOP2A 0.0071
731 HIV-1 protease HIV-1 protease 0.007
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0069
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0069
146 Androgen receptor AR 0.0068
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
373 Transthyretin TTR 0.0067
2320 Thymidine kinase, cytosolic TK1 0.0066
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0065
831 D(2) dopamine receptor DRD2 0.0065
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0064
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0063
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0063
713 Sodium-dependent dopamine transporter SLC6A3 0.0063
23 D(1A) dopamine receptor DRD1 0.0062
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0061
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0061
766 Beta-2 adrenergic receptor ADRB2 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
6141 Sodium/bile acid cotransporter SLC10A1 0.0058
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0057
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0057
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0057
6031 Cytochrome P450 3A43 CYP3A43 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0053
6147 Solute carrier family 22 member 3 SLC22A3 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
5482 Sialidase-2 NEU2 0.0052
1898 Cytochrome P450 1B1 CYP1B1 0.0052
502 5-hydroxytryptamine 2A receptor HTR2A 0.0052
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6148 Multidrug resistance-associated protein 7 ABCC10 0.005
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.005
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
3939 Amine oxidase [flavin-containing] B MAOB 0.0048
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0047
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0046
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0046
124 Histamine H2 receptor HRH2 0.0046
468 Cytochrome P450 4A11 CYP4A11 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0045
638 D(3) dopamine receptor DRD3 0.0044
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
275 Arachidonate 5-lipoxygenase ALOX5 0.0043
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0042
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0042
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0041
408 Riboflavin kinase RFK 0.0041
24 Thymidylate synthase TMP1 0.0041
359 Thymidylate synthase TYMS 0.0041
2626 Thymidylate synthase thyA 0.0041
2729 Thymidylate synthase thyA 0.0041
5352 Thymidylate synthase THYA 0.0041
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0039
6131 Carbonic anhydrase 14 CA14 0.0039
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0039
432 D(4) dopamine receptor DRD4 0.0039
183 Vascular endothelial growth factor A VEGFA 0.0038
122 P2Y purinoceptor 12 P2RY12 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0037
590 5-hydroxytryptamine 2C receptor HTR2C 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
6122 Carbonic anhydrase 3 CA3 0.0037
6149 Solute carrier family 22 member 10 SLC22A10 0.0036
3007 Carbonic anhydrase 12 CA12 0.0036
4205 Carbonic anhydrase 9 CA9 0.0036
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0036
320 5-hydroxytryptamine 1A receptor HTR1A 0.0035
380 Cytochrome P450 17A1 CYP17A1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1196 Complement decay-accelerating factor CD55 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
70 Type-1 angiotensin II receptor AGTR1 0.0032
6137 Multidrug resistance-associated protein 6 ABCC6 0.0032
6182 Cytochrome P450 2J2 CYP2J2 0.0032
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
341 5-hydroxytryptamine 3 receptor HTR3A 0.003
789 Alpha-1D adrenergic receptor ADRA1D 0.003
136 Estrogen receptor ESR1 0.003
2808 Chloramphenicol acetyltransferase 3 cat3 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
654 Flavin reductase BLVRB 0.0029
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0029
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0029
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0029
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
1867 Major prion protein PRNP 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
2417 Chloramphenicol acetyltransferase cat 0.0027
3278 Chloramphenicol acetyltransferase cat 0.0027
1025 Aquaporin-1 AQP1 0.0027
2810 Dr hemagglutinin structural subunit draA 0.0027
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0027
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
49 Endothelin B receptor EDNRB 0.0027
6102 Arylamine N-acetyltransferase 2 NAT2 0.0026
777 Tumor necrosis factor TNF 0.0026
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0026
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0026
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0026
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0026
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0026
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0026
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0026
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0026
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0026
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0026
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0026
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0026
293 Gamma-glutamyl hydrolase GGH 0.0026
4773 Deoxycytidine kinase DCK 0.0026
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0026
885 5-hydroxytryptamine 1B receptor HTR1B 0.0026
85 Growth hormone receptor GHR 0.0025
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0025
130 Prostacyclin synthase PTGIS 0.0025
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0024
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0024
921 Glutamate receptor 2 GRIA2 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
1650 Heme carrier protein 1 SLC46A1 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
465 Calmodulin CALM1 0.0022
4217 Telomerase reverse transcriptase TERT 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0022
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
634 Squalene monooxygenase SQLE 0.0021
7196 Squalene monooxygenase ERG1 0.0021
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0021
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
527 Prostacyclin receptor PTGIR 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
725 5-hydroxytryptamine 1D receptor HTR1D 0.0021
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0021
696 Kappa-type opioid receptor OPRK1 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
161 Tubulin beta chain TUBB 0.002
312 Tubulin beta chain TUB2 0.002
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
1654 Interleukin-1 beta IL1B 0.0019
1656 CYP2B protein CYP2B 0.0019
4120 NADPH--cytochrome P450 reductase POR 0.0019
2981 Phospholipase A2, membrane associated PLA2G2A 0.0019
1253 Interferon gamma IFNG 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
2021 Thrombomodulin THBD 0.0018
1010 Cytochrome P450 51A1 CYP51A1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
756 Sex hormone-binding globulin SHBG 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
427 Substance-P receptor TACR1 0.0018
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0017
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0017
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0017
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
528 5-hydroxytryptamine 1E receptor HTR1E 0.0017
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0017
891 Dihydropteroate synthase folP 0.0017
5359 Dihydropteroate synthase folP 0.0017
7175 Dihydropteroate synthase sulI 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
6432 Transporter snf 0.0016
847 Mu-type opioid receptor OPRM1 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
436 5-hydroxytryptamine 2B receptor HTR2B 0.0016
823 Fibroblast growth factor receptor 2 FGFR2 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0015
494 Caspase-1 CASP1 0.0015
6218 Pannexin-1 PANX1 0.0015
1192 Sulfotransferase 1A1 SULT1A1 0.0015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0015
1039 Histone deacetylase 9 HDAC9 0.0015
6085 Fatty acid-binding protein, intestinal FABP2 0.0015
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0015
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0015
1507 Cytochrome c CYCS 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
365 Dihydrofolate reductase DHFR 0.0014
2381 Dihydrofolate reductase DFR1 0.0014
2833 Dihydrofolate reductase Not Available 0.0014
2931 Dihydrofolate reductase folA 0.0014
3544 Dihydrofolate reductase folA 0.0014
3682 Dihydrofolate reductase folA 0.0014
6642 Dihydrofolate reductase folA 0.0014
6756 Dihydrofolate reductase dfrA 0.0014
716 5-hydroxytryptamine 7 receptor HTR7 0.0014
629 Alpha-2B adrenergic receptor ADRA2B 0.0014
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0014
614 Progesterone receptor PGR 0.0014
1618 High affinity nerve growth factor receptor NTRK1 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
822 Aldose reductase AKR1B1 0.0014
4311 tRNA TRDMT1 0.0013
4325 tRNA trmD 0.0013
4328 tRNA trmD 0.0013
228 Beta platelet-derived growth factor receptor PDGFRB 0.0013
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
33 Cystine/glutamate transporter SLC7A11 0.0013
106 Cannabinoid receptor 2 CNR2 0.0013
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0013
518 Peroxidase/catalase T katG 0.0013
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0013
6174 50S ribosomal protein L32 rpmF 0.0013
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0013
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0013
4238 50S ribosomal protein L4 rplD 0.0013
5578 50S ribosomal protein L4 rplD 0.0013
6173 50S ribosomal protein L4 rplD 0.0013
6219 50S ribosomal protein L4 rplD 0.0013
2077 Caspase-3 CASP3 0.0013
871 Glucocorticoid receptor NR3C1 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
1792 Tissue-type plasminogen activator PLAT 0.0012
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0012
504 Mast/stem cell growth factor receptor KIT 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
68 Cannabinoid receptor 1 CNR1 0.0012
563 Thyroid peroxidase TPO 0.0012
811 Translocator protein TSPO 0.0012
273 Apoptosis regulator Bcl-2 BCL2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0011
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0011
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0011
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0011
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0011
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.001
3601 Dihydropteroate synthase 1 folP1 0.001
3807 Dihydropteroate synthase 1 folP1 0.001
3808 Dihydropteroate synthase 2 folP2 0.001
997 Protein kinase C beta type PRKCB 0.001
1313 Lactoylglutathione lyase GLO1 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
581 Cytochrome P450 2R1 CYP2R1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
378 Alpha-2C adrenergic receptor ADRA2C 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0009
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3830 Calreticulin CALR 0.0009
1992 Vitamin D-binding protein GC 0.0009
319 Opioid receptor, sigma 1 OPRS1 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0009
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0009
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
1256 5-hydroxytryptamine 6 receptor HTR6 0.0009
976 Platelet glycoprotein IX GP9 0.0009
1630 Integrin beta-2 ITGB2 0.0008
5818 Folate receptor alpha FOLR1 0.0008
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0008
4102 Proteasome subunit beta type 5 PSMB5 0.0008
4101 Proteasome subunit beta type 1 PSMB1 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
3587 Gastrotropin FABP6 0.0008
511 5-hydroxytryptamine 1F receptor HTR1F 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
6146 High affinity copper uptake protein 1 SLC31A1 0.0008
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0008
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0008
239 Coagulation factor X F10 0.0008
6020 Aldehyde oxidase AOX1 0.0008
174 Sigma 1-type opioid receptor SIGMAR1 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6044 Serum paraoxonase/lactonase 3 PON3 0.0007
1517 Beta-3 adrenergic receptor ADRB3 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
856 Vitamin D3 receptor VDR 0.0007
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
572 Integrin alpha-L ITGAL 0.0006
904 Glutathione S-transferase P GSTP1 0.0006
5798 Mitogen-activated protein kinase 11 MAPK11 0.0006
267 Plasminogen activator inhibitor 1 SERPINE1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
482 Glycine receptor subunit alpha-1 GLRA1 0.0006
4122 Histone deacetylase 2 HDAC2 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0006
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0006
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0006
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0006
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0006
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0006
153 Dopamine beta-hydroxylase DBH 0.0006
869 Estrogen receptor beta ESR2 0.0006
7 Nitric oxide synthase, inducible NOS2 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
5934 Cytochrome P450 26A1 CYP26A1 0.0006
6221 Steroid hormone receptor ERR1 ESRRA 0.0006
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
936 Ephrin type-A receptor 2 EPHA2 0.0005
165 FL cytokine receptor FLT3 0.0005
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
5787 Angiopoietin-1 receptor TEK 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
469 Annexin A1 ANXA1 0.0004
3809 Estrogen-related receptor gamma ESRRG 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0004
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0003
164 Histamine H4 receptor HRH4 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0003
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0003
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