DT-Web: DB01065

Identification

Name

Melatonin

Accession Number

DB01065 (APRD00742, DB08189)

Type

small molecule

Description

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus) but outside the blood-brain barrier. The secretion of melatonin increases in darkness and decreases during exposure to light, thereby regulating the circadian rhythms of several biological functions, including the sleep-wake cycle. In particular, melatonin regulates the sleep-wake cycle by chemically causing drowsiness and lowering the body temperature. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors. Individuals with autism spectrum disorders (ASD) may have lower than normal levels of melatonin. A 2008 study found that unaffected parents of individuals with ASD also have lower melatonin levels, and that the deficits were associated with low activity of the ASMT gene, which encodes the last enzyme of melatonin synthesis. Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

232.2783

Groups

approved

Monoisotopic Weight

232.121177766

Pharmacology

Indication

Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for this use. A number of studies have shown that melatonin may be effective for treating sleep-wake cycle disturbances in children and adolescents with mental retardation, autism, and other central nervous system disorders. It appears to decrease the time to fall asleep in children with developmental disabilities, such as cerebral palsy, autism, and mental retardation. It may also improve secondary insomnia associated with various sleep-wake cycle disturbances. Other possible uses for which there is some evidence for include: benzodiazepine withdrawal, cluster headache, delayed sleep phase syndrome (DSPS), primary insomnia, jet lag, nicotine withdrawal, preoperative anxiety and sedation, prostate cancer, solid tumors (when combined with IL-2 therapy in certain cancers), sunburn prevention (topical use), tardive dyskinesia, thrombocytopenia associated with cancer, chemotherapy and other disorders.

Mechanism of action

Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate. By binding to melatonin receptors 1 and 2, the downstream signallling cascades have various effects in the body. The melatonin receptors are G protein-coupled receptors and are expressed in various tissues of the body. There are two subtypes of the receptor in humans, melatonin receptor 1 (MT1) and melatonin receptor 2 (MT2). Melatonin and melatonin receptor agonists, on market or in clinical trials, all bind to and activate both receptor types.The binding of the agonists to the receptors has been investigated for over two decades or since 1986. It is somewhat known, but still not fully understood. When melatonin receptor agonists bind to and activate their receptors it causes numerous physiological processes. MT1 receptors are expressed in many regions of the central nervous system (CNS): suprachiasmatic nucleus of the hypothalamus (SNC), hippocampus, substantia nigra, cerebellum, central dopaminergic pathways, ventral tegmental area and nucleus accumbens. MT1 is also expressed in the retina, ovary, testis, mammary gland, coronary circulation and aorta, gallbladder, liver, kidney, skin and the immune system. MT2 receptors are expressed mainly in the CNS, also in the lung, cardiac, coronary and aortic tissue, myometrium and granulosa cells, immune cells, duodenum and adipocytes. The binding of melatonin to melatonin receptors activates a few signaling pathways. MT1 receptor activation inhibits the adenylyl cyclase and its inhibition causes a rippling effect of non activation; starting with decreasing formation of cyclic adenosine monophosphate (cAMP), and then progressing to less protein kinase A (PKA) activity, which in turn hinders the phosphorilation of cAMP responsive element-binding protein (CREB binding protein) into P-CREB. MT1 receptors also activate phospholipase C (PLC), affect ion channels and regulate ion flux inside the cell. The binding of melatonin to MT2 receptors inhibits adenylyl cyclase which decreases the formation of cAMP.[4] As well it hinders guanylyl cyclase and therefore the forming of cyclic guanosine monophosphate (cGMP). Binding to MT2 receptors probably affects PLC which increases protein kinase C (PKC) activity. Activation of the receptor can lead to ion flux inside the cell.

Absorption

The absorption and bioavailability of melatonin varies widely.

Protein binding

n/a

Biotransformation

Hepatically metabolized to at least 14 identified metabolites (identified in mouse urine): 6-hydroxymelatonin glucuronide, 6-hydroxymelatonin sulfate, N-acetylserotonin glucuronide, N-acetylserotonin sulfate, 6-hydroxymelatonin, 2-oxomelatonin, 3-hydroxymelatonin, melatonin glucuronide, cyclic melatonin, cyclic N-acetylserotonin glucuronide, cyclic 6-hydroxymelatonin, 5-hydroxyindole-3-acetaldehyde, di-hydroxymelatonin and its glucuronide conjugate. 6-Hydroxymelatonin glucuronide is the major metabolite found in mouse urine (65-88% of total melatonin metabolites in urine).

Route of elimination

Not Available

Toxicity

Generally well-tolerated when taken orally. The most common side effects, day-time drowsiness, headache and dizziness, appear to occur at the same frequency as with placebo. Other reported side effects include transient depressive symptoms, mild tremor, mild anxiety, abdominal cramps, irritability, reduced alertness, confusion, nausea, vomiting, and hypotension. Safety in Adults: Evidence indicates that it is likely safe to use in oral and parenteral forms for up to two months when used appropriately. Some evidence indicates that it can be safely used orally for up to 9 months in some patients. It is also likely safe to use topically when used appropriately. Safety in Children: Melatonin appeared to be used safely in small numbers of children enrolled in short-term clinical trials. However, concerns regarding safety in children have arisen based on their developmental state. Compared to adults over 20 years of age, people under 20 produce high levels of melatonin. Melatonin levels are inversely related to gonadal development and it is thought that exogenous administration of melatonin may adversely affect gonadal development. Safety during Pregnancy: High doses of melatonin administered orally or parenterally may inhibit ovulation. Not advised for use in individuals who are pregnant or trying to become pregnant. Safety during Lactation: Not recommended as safety has not be established.

Oral, rat: LD₅₀ ≥3200 mg/kg

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Nifedipine	Melatonin can possibly decrease the effect of nifedipine

Food Interactions

Not Available

Melatonin receptor type 1A
Name	Melatonin receptor type 1A
Gene Name	MTNR1A
Pharmacological action	yes
Actions	agonist
References	Radogna F, Paternoster L, De Nicola M, Cerella C, Ammendola S, Bedini A, Tarzia G, Aquilano K, Ciriolo M, Ghibelli L: Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):37-45. Epub 2009 May 19. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Boutin JA, Audinot V, Ferry G, Delagrange P: Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci. 2005 Aug;26(8):412-9. - Pubmed Hardeland R: Melatonin: signaling mechanisms of a pleiotropic agent. Biofactors. 2009 Mar-Apr;35(2):183-92. - Pubmed Srinivasan V, Singh J, Pandi-Perumal SR, Brown GM, Spence DW, Cardinali DP: Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Adv Ther. 2010 Nov;27(11):796-813. Epub 2010 Sep 6. - Pubmed Carocci A, Catalano A, Lovece A, Lentini G, Duranti A, Lucini V, Pannacci M, Scaglione F, Franchini C: Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem. 2010 Sep 1;18(17):6496-511. Epub 2010 Jul 3. - Pubmed Prendergast BJ: MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus). Endocrinology. 2010 Feb;151(2):714-21. Epub 2009 Dec 4. - Pubmed
DTHybrid score	0.7787
Melatonin receptor type 1B
Name	Melatonin receptor type 1B
Gene Name	MTNR1B
Pharmacological action	yes
Actions	agonist
References	Radogna F, Paternoster L, De Nicola M, Cerella C, Ammendola S, Bedini A, Tarzia G, Aquilano K, Ciriolo M, Ghibelli L: Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):37-45. Epub 2009 May 19. - Pubmed Boutin JA, Audinot V, Ferry G, Delagrange P: Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci. 2005 Aug;26(8):412-9. - Pubmed Hardeland R: Melatonin: signaling mechanisms of a pleiotropic agent. Biofactors. 2009 Mar-Apr;35(2):183-92. - Pubmed Srinivasan V, Singh J, Pandi-Perumal SR, Brown GM, Spence DW, Cardinali DP: Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Adv Ther. 2010 Nov;27(11):796-813. Epub 2010 Sep 6. - Pubmed Carocci A, Catalano A, Lovece A, Lentini G, Duranti A, Lucini V, Pannacci M, Scaglione F, Franchini C: Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem. 2010 Sep 1;18(17):6496-511. Epub 2010 Jul 3. - Pubmed Prendergast BJ: MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus). Endocrinology. 2010 Feb;151(2):714-21. Epub 2009 Dec 4. - Pubmed
DTHybrid score	0.7787
Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	unknown
Actions	antagonist
References	del Rio B, Garcia Pedrero JM, Martinez-Campa C, Zuazua P, Lazo PS, Ramos S: Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin. J Biol Chem. 2004 Sep 10;279(37):38294-302. Epub 2004 Jun 30. - Pubmed Yoo YM, Jeung EB: Melatonin-induced estrogen receptor alpha-mediated calbindin-D9k expression plays a role in H2O2-mediated cell death in rat pituitary GH3 cells. J Pineal Res. 2009 Nov;47(4):301-7. Epub 2009 Oct 1. - Pubmed
DTHybrid score	0.8948
Nuclear receptor ROR-beta
Name	Nuclear receptor ROR-beta
Gene Name	RORB
Pharmacological action	unknown
Actions	agonist
References	Becker-Andre M, Wiesenberg I, Schaeren-Wiemers N, Andre E, Missbach M, Saurat JH, Carlberg C: Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem. 1994 Nov 18;269(46):28531-4. - Pubmed
DTHybrid score	0.4909
Calmodulin
Name	Calmodulin
Gene Name	CALM1
Pharmacological action	unknown
Actions	Not Available
References	del Rio B, Garcia Pedrero JM, Martinez-Campa C, Zuazua P, Lazo PS, Ramos S: Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin. J Biol Chem. 2004 Sep 10;279(37):38294-302. Epub 2004 Jun 30. - Pubmed Radogna F, Paternoster L, De Nicola M, Cerella C, Ammendola S, Bedini A, Tarzia G, Aquilano K, Ciriolo M, Ghibelli L: Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):37-45. Epub 2009 May 19. - Pubmed
DTHybrid score	0.5644
Myeloperoxidase
Name	Myeloperoxidase
Gene Name	MPO
Pharmacological action	unknown
Actions	inhibitor
References	Galijasevic S, Abdulhamid I, Abu-Soud HM: Melatonin is a potent inhibitor for myeloperoxidase. Biochemistry. 2008 Feb 26;47(8):2668-77. Epub 2008 Feb 1. - Pubmed
DTHybrid score	0.5072
Eosinophil peroxidase
Name	Eosinophil peroxidase
Gene Name	EPX
Pharmacological action	unknown
Actions	inhibitor
References	Lu T, Galijasevic S, Abdulhamid I, Abu-Soud HM: Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase. Br J Pharmacol. 2008 Jul;154(6):1308-17. Epub 2008 Jun 2. - Pubmed
DTHybrid score	0.4912
Calreticulin
Name	Calreticulin
Gene Name	CALR
Pharmacological action	unknown
Actions	Not Available
References	Hardeland R: Melatonin: signaling mechanisms of a pleiotropic agent. Biofactors. 2009 Mar-Apr;35(2):183-92. - Pubmed Macias M, Escames G, Leon J, Coto A, Sbihi Y, Osuna A, Acuna-Castroviejo D: Calreticulin-melatonin. An unexpected relationship. Eur J Biochem. 2003 Mar;270(5):832-40. - Pubmed
DTHybrid score	0.5158
Hydroxyindole O-methyltransferase
Name	Hydroxyindole O-methyltransferase
Gene Name	ASMT
Pharmacological action	unknown
Actions	Not Available
References	Minneman KP, Wurtman RJ: The pharmacology of the pineal gland. Annu Rev Pharmacol Toxicol. 1976;16:33-51. - Pubmed
DTHybrid score	0.491
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name	Ribosyldihydronicotinamide dehydrogenase [quinone]
Gene Name	NQO2
Pharmacological action	unknown
Actions	Not Available
References	Radogna F, Paternoster L, De Nicola M, Cerella C, Ammendola S, Bedini A, Tarzia G, Aquilano K, Ciriolo M, Ghibelli L: Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):37-45. Epub 2009 May 19. - Pubmed
DTHybrid score	0.9255

Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate,inhibitor
References	Chang TK, Chen J, Yang G, Yeung EY: Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. J Pineal Res. 2010 Jan;48(1):55-64. Epub 2009 Nov 16. - Pubmed Ma X, Idle JR, Krausz KW, Gonzalez FJ: Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94. Epub 2004 Dec 22. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4527
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Chang TK, Chen J, Yang G, Yeung EY: Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. J Pineal Res. 2010 Jan;48(1):55-64. Epub 2009 Nov 16. - Pubmed Ma X, Idle JR, Krausz KW, Gonzalez FJ: Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94. Epub 2004 Dec 22. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Turpeinen M, Uusitalo J, Jalonen J, Pelkonen O: Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. Eur J Pharm Sci. 2005 Jan;24(1):123-32. - Pubmed
DTHybrid score	0.7242
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate,inhibitor
References	Chang TK, Chen J, Yang G, Yeung EY: Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. J Pineal Res. 2010 Jan;48(1):55-64. Epub 2009 Nov 16. - Pubmed Ma X, Idle JR, Krausz KW, Gonzalez FJ: Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94. Epub 2004 Dec 22. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3601
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Huuhka K, Riutta A, Haataja R, Ylitalo P, Leinonen E: The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study. Methods Find Exp Clin Pharmacol. 2006 Sep;28(7):447-50. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5432
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. - Pubmed
DTHybrid score	0.6076
Hydroxyindole O-methyltransferase
Name	Hydroxyindole O-methyltransferase
Gene Name	ASMT
Actions	substrate
References	Minneman KP, Wurtman RJ: The pharmacology of the pineal gland. Annu Rev Pharmacol Toxicol. 1976;16:33-51. - Pubmed
DTHybrid score	0.491
Indoleamine 2,3-dioxygenase
Name	Indoleamine 2,3-dioxygenase
Gene Name	IDO1
Actions	substrate
References	Ferry G, Ubeaud C, Lambert PH, Bertin S, Coge F, Chomarat P, Delagrange P, Serkiz B, Bouchet JP, Truscott RJ, Boutin JA: Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochem J. 2005 May 15;388(Pt 1):205-15. - Pubmed
DTHybrid score	0.4896
Myeloperoxidase
Name	Myeloperoxidase
Gene Name	MPO
Actions	substrate,inhibitor
References	Ferry G, Ubeaud C, Lambert PH, Bertin S, Coge F, Chomarat P, Delagrange P, Serkiz B, Bouchet JP, Truscott RJ, Boutin JA: Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochem J. 2005 May 15;388(Pt 1):205-15. - Pubmed
DTHybrid score	0.5072
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.535

Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score	0.3349

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.4802
4119	Cytochrome P450 2D6	CYP2D6	0.2641
1588	Multidrug resistance protein 1	ABCB1	0.2314
6241	Nuclear receptor coactivator 2	NCOA2	0.2313
4924	Cytochrome P450 2C8	CYP2C8	0.2294
6013	Cytochrome P450 2E1	CYP2E1	0.1807
6030	Cytochrome P450 2B6	CYP2B6	0.1686
4118	Cytochrome P450 3A5	CYP3A5	0.1576
20	Prostaglandin G/H synthase 1	PTGS1	0.1208
5718	Cytochrome P450 2A6	CYP2A6	0.1179
1729	Solute carrier family 22 member 6	SLC22A6	0.1142
590	5-hydroxytryptamine 2C receptor	HTR2C	0.1133
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1092
6107	Cytochrome P450 3A7	CYP3A7	0.109
290	Prostaglandin G/H synthase 2	PTGS2	0.1063
1516	Calnexin	CANX	0.1037
869	Estrogen receptor beta	ESR2	0.0973
3831	Low-density lipoprotein receptor-related protein 1	LRP1	0.0952
587	Serum albumin	ALB	0.095
146	Androgen receptor	AR	0.0929
90	Tryptophan 5-hydroxylase 2	TPH2	0.0897
4063	Tryptophanyl-tRNA synthetase, mitochondrial	WARS2	0.0897
614	Progesterone receptor	PGR	0.0783
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0745
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0737
1024	Solute carrier family 22 member 11	SLC22A11	0.0713
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.068
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.068
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0673
252	Tryptophanyl-tRNA synthetase, cytoplasmic	WARS	0.0653
3825	Tetranectin	CLEC3B	0.0643
2111	Annexin A2	ANXA2	0.0643
3826	Keratin, type II cytoskeletal 8	KRT8	0.0643
3947	Xanthine dehydrogenase/oxidase	XDH	0.063
6143	Solute carrier family 22 member 7	SLC22A7	0.0628
6106	Cytochrome P450 2C18	CYP2C18	0.0605
54	Prothrombin	F2	0.0602
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0593
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0587
2452	Tryptophanyl-tRNA synthetase	trpS	0.0577
134	Tryptophan 5-hydroxylase 1	TPH1	0.0575
6145	Solute carrier family 22 member 1	SLC22A1	0.0569
1349	Plasminogen activator inhibitor 2	SERPINB2	0.056
400	Coagulation factor IX	F9	0.0553
5461	Coagulation factor IX	F9	0.0553
6144	Solute carrier family 22 member 2	SLC22A2	0.055
756	Sex hormone-binding globulin	SHBG	0.0545
3842	Multiple coagulation factor deficiency protein 2	MCFD2	0.0544
1847	78 kDa glucose-regulated protein	HSPA5	0.0544
3840	Asialoglycoprotein receptor 2	ASGR2	0.0544
3841	ERGIC-53 protein	LMAN1	0.0544
1635	von Willebrand factor	VWF	0.0543
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0519
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0507
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0506
199	Monocarboxylate transporter 8	SLC16A2	0.0505
862	Multidrug resistance-associated protein 1	ABCC1	0.0504
422	Vitamin K-dependent protein C	PROC	0.0489
776	Bile salt export pump	ABCB11	0.0485
563	Thyroid peroxidase	TPO	0.0479
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0478
239	Coagulation factor X	F10	0.0478
267	Plasminogen activator inhibitor 1	SERPINE1	0.0475
791	Urokinase plasminogen activator surface receptor	PLAUR	0.0466
118	Organic cation/carnitine transporter 2	SLC22A5	0.0458
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0455
3839	Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	0.0441
595	Fibrinogen alpha chain	FGA	0.0439
6020	Aldehyde oxidase	AOX1	0.0432
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.041
3941	Amine oxidase [flavin-containing] A	MAOA	0.0407
831	D(2) dopamine receptor	DRD2	0.0406
492	Histamine H1 receptor	HRH1	0.0398
260	Cytochrome P450 51	ERG11	0.0395
761	Cytochrome P450 51	ERG11	0.0395
3163	Cytochrome P450 51	cyp51	0.0395
234	Plasminogen	PLG	0.0389
1507	Cytochrome c	CYCS	0.0381
4228	Keratin, type II cytoskeletal 7	KRT7	0.038
6147	Solute carrier family 22 member 3	SLC22A3	0.0379
468	Cytochrome P450 4A11	CYP4A11	0.0372
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0369
2164	Multidrug resistance-associated protein 4	ABCC4	0.0363
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0362
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0354
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0352
6151	Monocarboxylate transporter 10	SLC16A10	0.035
722	Troponin I, cardiac muscle	TNNI3	0.0347
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0332
4604	Liver carboxylesterase 1	CES1	0.033
3939	Amine oxidase [flavin-containing] B	MAOB	0.0321
556	Alpha-1A adrenergic receptor	ADRA1A	0.0319
1736	Somatostatin	SST	0.0311
4186	Neuropeptide Y receptor type 2	NPY2R	0.0311
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0302
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0294
275	Arachidonate 5-lipoxygenase	ALOX5	0.0291
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0288
373	Transthyretin	TTR	0.0288
817	DNA topoisomerase 2-alpha	TOP2A	0.0286
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0283
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0277
23	D(1A) dopamine receptor	DRD1	0.0276
824	Sodium-dependent serotonin transporter	SLC6A4	0.0273
833	Organic cation/carnitine transporter 1	SLC22A4	0.0273
153	Dopamine beta-hydroxylase	DBH	0.0269
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0269
318	Alpha-2A adrenergic receptor	ADRA2A	0.0263
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0262
4116	Dihydropteroate synthetase	Not Available	0.0261
36	Insulin receptor	INSR	0.0258
3923	Cholinesterase	BCHE	0.0256
6148	Multidrug resistance-associated protein 7	ABCC10	0.0252
309	Antithrombin-III	SERPINC1	0.0251
6141	Sodium/bile acid cotransporter	SLC10A1	0.0248
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0245
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0245
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0239
713	Sodium-dependent dopamine transporter	SLC6A3	0.0238
3866	Serum amyloid A protein	SAA1	0.0236
1932	Apolipoprotein E	APOE	0.0236
1200	AMBP protein	AMBP	0.0236
766	Beta-2 adrenergic receptor	ADRB2	0.0235
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0235
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0233
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0232
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0224
871	Glucocorticoid receptor	NR3C1	0.0221
24	Thymidylate synthase	TMP1	0.0219
359	Thymidylate synthase	TYMS	0.0219
2626	Thymidylate synthase	thyA	0.0219
2729	Thymidylate synthase	thyA	0.0219
5352	Thymidylate synthase	THYA	0.0219
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0217
856	Vitamin D3 receptor	VDR	0.0214
503	Somatostatin receptor type 1	SSTR1	0.0214
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0214
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0213
122	P2Y purinoceptor 12	P2RY12	0.0212
6146	High affinity copper uptake protein 1	SLC31A1	0.0212
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0212
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0211
723	Cytosolic phospholipase A2	PLA2G4A	0.021
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0207
629	Alpha-2B adrenergic receptor	ADRA2B	0.0207
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0206
6136	Multidrug resistance-associated protein 5	ABCC5	0.0203
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0202
6014	Cytochrome P450 2A13	CYP2A13	0.0201
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0201
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0201
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0201
3872	Somatostatin receptor type 5	SSTR5	0.02
6008	Somatostatin receptor type 2	SSTR2	0.02
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0196
633	Penicillin-binding proteins 1A/1B	pbpA	0.0194
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0194
380	Cytochrome P450 17A1	CYP17A1	0.0193
2236	Casein kinase II subunit alpha	CSNK2A1	0.0193
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0191
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0187
1178	Adenosine A2a receptor	ADORA2A	0.0187
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0186
6165	Copper-transporting ATPase 1	ATP7A	0.0184
6163	Copper-transporting ATPase 2	ATP7B	0.0184
6220	Aryl hydrocarbon receptor	AHR	0.0181
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0181
193	Beta-1 adrenergic receptor	ADRB1	0.0179
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0177
632	Alpha-1B adrenergic receptor	ADRA1B	0.0177
847	Mu-type opioid receptor	OPRM1	0.0176
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0174
908	Glutathione S-transferase theta-1	GSTT1	0.0172
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0172
6031	Cytochrome P450 3A43	CYP3A43	0.0171
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0169
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0169
1089	Cartilage oligomeric matrix protein	COMP	0.0168
1108	Calpastatin	CAST	0.0168
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0167
777	Tumor necrosis factor	TNF	0.0166
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0164
6048	Troponin C, skeletal muscle	TNNC2	0.0163
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0161
6044	Serum paraoxonase/lactonase 3	PON3	0.0158
16	Adenosine A1 receptor	ADORA1	0.0157
124	Histamine H2 receptor	HRH2	0.0157
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0154
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0153
1010	Cytochrome P450 51A1	CYP51A1	0.0153
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0152
6137	Multidrug resistance-associated protein 6	ABCC6	0.0151
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
1852	Microtubule-associated protein 2	MAP2	0.0149
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0148
904	Glutathione S-transferase P	GSTP1	0.0147
638	D(3) dopamine receptor	DRD3	0.0147
896	Glutathione S-transferase Mu 1	GSTM1	0.0147
844	Epidermal growth factor receptor	EGFR	0.0147
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0147
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0146
2392	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0146
3032	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0146
731	HIV-1 protease	HIV-1 protease	0.0144
477	DNA topoisomerase 4 subunit A	parC	0.0144
886	DNA topoisomerase 4 subunit A	parC	0.0144
6226	DNA topoisomerase 4 subunit A	parC	0.0144
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0142
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0142
404	DNA gyrase subunit A	gyrA	0.0141
6224	DNA gyrase subunit A	gyrA	0.0141
6228	Nuclear receptor coactivator 1	NCOA1	0.0141
273	Apoptosis regulator Bcl-2	BCL2	0.0141
467	Delta-type opioid receptor	OPRD1	0.0139
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0139
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0137
378	Alpha-2C adrenergic receptor	ADRA2C	0.0136
3957	Adenosine deaminase	ADA	0.0136
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0136
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0135
4203	Histamine N-methyltransferase	HNMT	0.0135
789	Alpha-1D adrenergic receptor	ADRA1D	0.0131
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0129
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0128
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0127
696	Kappa-type opioid receptor	OPRK1	0.0126
2314	Triosephosphate isomerase	TPI	0.0123
3417	Triosephosphate isomerase	tpiA	0.0123
3443	Triosephosphate isomerase	tpiA	0.0123
6346	Triosephosphate isomerase	TPI1	0.0123
3810	Catechol O-methyltransferase	COMT	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0121
5682	Ribonuclease pancreatic	RNASE1	0.0121
725	5-hydroxytryptamine 1D receptor	HTR1D	0.012
891	Dihydropteroate synthase	folP	0.012
5359	Dihydropteroate synthase	folP	0.012
7175	Dihydropteroate synthase	sulI	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0119
1656	CYP2B protein	CYP2B	0.0119
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
2795	Methionine aminopeptidase 2	METAP2	0.0117
48	Pyridoxal kinase	PDXK	0.0116
2016	Dipeptidase 1	DPEP1	0.0115
6102	Arylamine N-acetyltransferase 2	NAT2	0.0115
159	Penicillin-binding protein 2B	penA	0.0115
6121	Penicillin-binding protein 2B	penA	0.0115
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0114
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0113
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0111
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.011
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.011
5934	Cytochrome P450 26A1	CYP26A1	0.011
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0109
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0108
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0108
1649	Small inducible cytokine A2	CCL2	0.0108
6859	Protein S100-A4	S100A4	0.0108
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0106
3809	Estrogen-related receptor gamma	ESRRG	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0105
6085	Fatty acid-binding protein, intestinal	FABP2	0.0105
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0104
482	Glycine receptor subunit alpha-1	GLRA1	0.0104
4120	NADPH--cytochrome P450 reductase	POR	0.0104
738	Monocarboxylate transporter 1	SLC16A1	0.0103
70	Type-1 angiotensin II receptor	AGTR1	0.0103
6168	Solute carrier family 22 member 16	SLC22A16	0.0102
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0102
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0102
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0102
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0102
22	30S ribosomal protein S4	rpsD	0.0101
6714	30S ribosomal protein S4	rpsD	0.0101
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0101
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0101
338	DNA polymerase	UL30	0.01
379	DNA polymerase	UL54	0.01
697	DNA polymerase	ORF28	0.01
2482	DNA polymerase	43	0.01
4104	DNA polymerase	BALF5	0.01
5923	Microtubule-associated protein tau	MAPT	0.01
5924	Microtubule-associated protein 4	MAP4	0.01
1192	Sulfotransferase 1A1	SULT1A1	0.01
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0099
1517	Beta-3 adrenergic receptor	ADRB3	0.0098
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0097
604	Vitamin K-dependent protein Z	PROZ	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
1714	Mitogen-activated protein kinase 3	MAPK3	0.0096
2132	Protein S100-B	S100B	0.0096
140	30S ribosomal protein S9	rpsI	0.0095
6719	30S ribosomal protein S9	rpsI	0.0095
6725	30S ribosomal protein S9	rpsI	0.0095
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0095
2499	Tubulin beta-2C chain	TUBB2C	0.0094
381	Prolactin receptor	PRLR	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0092
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0092
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0092
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0091
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.009
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.009
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.009
6167	Organic solute transporter subunit beta	OSTB	0.009
6166	Organic solute transporter subunit alpha	OSTA	0.009
4122	Histone deacetylase 2	HDAC2	0.0089
1629	Transcription factor AP-1	JUN	0.0088
183	Vascular endothelial growth factor A	VEGFA	0.0087
1245	Vitamin K-dependent protein S	PROS1	0.0087
504	Mast/stem cell growth factor receptor	KIT	0.0086
2449	Tubulin alpha-3 chain	TUBA1A	0.0086
634	Squalene monooxygenase	SQLE	0.0086
7196	Squalene monooxygenase	ERG1	0.0086
543	Penicillin-binding protein 1B	mrcB	0.0086
6186	Penicillin-binding protein 1B	ponB	0.0086
6822	Penicillin-binding protein 1b	pbp1b	0.0086
6844	Penicillin-binding protein 1b	pbp1b	0.0086
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0086
29	Tubulin beta-1 chain	TUBB1	0.0085
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0085
645	Penicillin-binding protein 1A	mrcA	0.0084
5805	Penicillin-binding protein 1A	ponA	0.0084
6185	Penicillin-binding protein 1A	mrcA	0.0084
6799	Penicillin-binding protein 1A	pbpA	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
780	Retinoic acid receptor RXR-gamma	RXRG	0.0084
3601	Dihydropteroate synthase 1	folP1	0.0084
3807	Dihydropteroate synthase 1	folP1	0.0084
3808	Dihydropteroate synthase 2	folP2	0.0084
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0083
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0083
737	Mineralocorticoid receptor	NR3C2	0.0083
432	D(4) dopamine receptor	DRD4	0.008
798	Osteocalcin	BGLAP	0.008
1569	G1/S-specific cyclin-D1	CCND1	0.0079
33	Cystine/glutamate transporter	SLC7A11	0.0079
6182	Cytochrome P450 2J2	CYP2J2	0.0079
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0079
5626	Nucleoside diphosphate kinase B	NME2	0.0079
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0079
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0079
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0079
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0079
992	Protein tyrosine kinase 2 beta	PTK2B	0.0079
84	Nuclear receptor 0B1	NR0B1	0.0078
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0078
6149	Solute carrier family 22 member 10	SLC22A10	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0078
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
551	Carnitine O-acetyltransferase	CRAT	0.0078
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0077
88	Retinoic acid receptor RXR-beta	RXRB	0.0076
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0076
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0076
3426	Glutamine synthetase	glnA	0.0076
3987	Glutamine synthetase	GLUL	0.0076
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0076
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0075
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0075
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0075
2107	Microtubule-associated protein 1A	MAP1A	0.0075
527	Prostacyclin receptor	PTGIR	0.0074
369	Coagulation factor VII	F7	0.0074
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0074
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0073
1176	Mitogen-activated protein kinase 1	MAPK1	0.0073
130	Prostacyclin synthase	PTGIS	0.0072
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0072
558	Solute carrier family 12 member 1	SLC12A1	0.0072
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0072
459	Retinoic acid receptor RXR-alpha	RXRA	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.007
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
49	Endothelin B receptor	EDNRB	0.007
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.007
921	Glutamate receptor 2	GRIA2	0.0069
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0069
820	Glycine receptor subunit alpha-2	GLRA2	0.0069
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0069
705	Glutamate receptor 1	GRIA1	0.0068
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0068
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0068
7	Nitric oxide synthase, inducible	NOS2	0.0068
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
814	Ryanodine receptor 1	RYR1	0.0067
592	Carbonic anhydrase 4	CA4	0.0067
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0067
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0067
295	Carbonic anhydrase 1	CA1	0.0066
578	Endothelin-1 receptor	EDNRA	0.0066
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0065
5294	Nucleoside diphosphate kinase A	NME1	0.0065
1262	Corticotropin-lipotropin	POMC	0.0064
357	Carbonic anhydrase 2	CA2	0.0064
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
365	Dihydrofolate reductase	DHFR	0.0063
2381	Dihydrofolate reductase	DFR1	0.0063
2833	Dihydrofolate reductase	Not Available	0.0063
2931	Dihydrofolate reductase	folA	0.0063
3544	Dihydrofolate reductase	folA	0.0063
3682	Dihydrofolate reductase	folA	0.0063
6642	Dihydrofolate reductase	folA	0.0063
6756	Dihydrofolate reductase	dfrA	0.0063
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0063
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0063
714	Glutathione reductase, mitochondrial	GSR	0.0063
133	Dihydropterate synthase	sulI	0.0063
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0062
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0062
474	Acetylcholinesterase	ACHE	0.006
268	Adenosine A2b receptor	ADORA2B	0.006
936	Ephrin type-A receptor 2	EPHA2	0.006
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
162	Retinoic acid receptor gamma-1	RARG	0.006
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0059
823	Fibroblast growth factor receptor 2	FGFR2	0.0059
427	Substance-P receptor	TACR1	0.0059
716	5-hydroxytryptamine 7 receptor	HTR7	0.0058
6766	O-GlcNAcase BT_4395	BT_4395	0.0058
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0058
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
469	Annexin A1	ANXA1	0.0057
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0057
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0057
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0057
94	5-hydroxytryptamine 4 receptor	HTR4	0.0056
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0056
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
407	Vascular endothelial growth factor receptor 2	KDR	0.0055
6043	Putative G-protein coupled receptor 44	GPR44	0.0055
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0054
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0054
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0054
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0054
5353	Glutamate decarboxylase alpha	gadA	0.0054
4192	DNA topoisomerase 2-beta	TOP2B	0.0053
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0053
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0053
4210	Toll-like receptor 4	TLR4	0.0053
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0053
1275	Estrogen sulfotransferase	SULT1E1	0.0053
229	Retinoic acid receptor beta	RARB	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
4311	tRNA	TRDMT1	0.0052
4325	tRNA	trmD	0.0052
4328	tRNA	trmD	0.0052
26	Vascular endothelial growth factor receptor 3	FLT4	0.0052
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0052
811	Translocator protein	TSPO	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
730	Retinoic acid receptor alpha	RARA	0.0051
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0051
484	Tyrosine-protein kinase ABL2	ABL2	0.0051
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0051
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0051
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0051
106	Cannabinoid receptor 2	CNR2	0.005
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.005
6126	Carbonic anhydrase 7	CA7	0.005
2981	Phospholipase A2, membrane associated	PLA2G2A	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
32	Vascular endothelial growth factor receptor 1	FLT1	0.005
144	Hemoglobin subunit alpha	HBA1	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0048
3937	Fatty-acid amide hydrolase	FAAH	0.0047
3932	Glutathione S-transferase A2	GSTA2	0.0047
68	Cannabinoid receptor 1	CNR1	0.0047
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0047
1405	Thiopurine S-methyltransferase	TPMT	0.0047
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0046
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0046
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0046
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0046
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0045
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0045
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0045
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0044
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0044
163	D(1B) dopamine receptor	DRD5	0.0044
818	50S ribosomal protein L10	rplJ	0.0043
251	Alcohol dehydrogenase 1A	ADH1A	0.0043
6221	Steroid hormone receptor ERR1	ESRRA	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0041
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.004
976	Platelet glycoprotein IX	GP9	0.004
164	Histamine H4 receptor	HRH4	0.004
517	Alcohol dehydrogenase 1C	ADH1C	0.004
6033	High affinity interleukin-8 receptor A	CXCR1	0.004
1867	Major prion protein	PRNP	0.0039
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0039
4103	Proteasome subunit beta type 2	PSMB2	0.0039
4102	Proteasome subunit beta type 5	PSMB5	0.0039
4101	Proteasome subunit beta type 1	PSMB1	0.0039
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0039
444	Alcohol dehydrogenase 1B	ADH1B	0.0039
5482	Sialidase-2	NEU2	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0039
3685	Catabolite gene activator	crp	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0038
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0038
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0038
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0038
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0038
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0038
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0038
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0037
569	Retinal dehydrogenase 2	ALDH1A2	0.0037
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
581	Cytochrome P450 2R1	CYP2R1	0.0037
518	Peroxidase/catalase T	katG	0.0036
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0036
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
611	Retinal dehydrogenase 1	ALDH1A1	0.0035
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0035
115	Penicillin-binding protein 2	mrdA	0.0035
6069	Penicillin-binding protein 2	mrdA	0.0035
6118	Penicillin-binding protein 2	penA	0.0035
6187	Penicillin-binding protein 2	pbpA	0.0035
6686	Penicillin-binding protein 2	pbp2	0.0035
6939	Penicillin-binding protein 2	mrdA	0.0035
7163	Penicillin-binding protein 2	pbpA	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
952	Dipeptidyl peptidase 4	DPP4	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
1992	Vitamin D-binding protein	GC	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0034
6209	30S ribosomal protein S19	rpsS	0.0034
6712	30S ribosomal protein S19	rpsS	0.0034
6726	30S ribosomal protein S19	rpsS	0.0034
6207	30S ribosomal protein S14	rpsN	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
712	Tubulin alpha chain	TUB1	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
3814	Complement C1r subcomponent	C1R	0.0034
4217	Telomerase reverse transcriptase	TERT	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0033
751	Potassium channel subfamily K member 6	KCNK6	0.0033
1618	High affinity nerve growth factor receptor	NTRK1	0.0033
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
1291	cAMP response element-binding protein	CREB1	0.0033
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0033
4760	Mll3241 protein	mll3241	0.0032
1648	Elastin	ELN	0.0032
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0032
1	Peptidoglycan synthetase ftsI	ftsI	0.0032
4155	Peptidoglycan synthetase ftsI	ftsI	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
65	Matrix metalloproteinase-9	Not Available	0.0032
291	Nitric-oxide synthase, endothelial	NOS3	0.0031
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0031
758	Thyroid hormone receptor alpha	THRA	0.0031
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0031
1374	Natriuretic peptides B	NPPB	0.0031
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0031
1827	Gap junction alpha-1 protein	GJA1	0.0031
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0031
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0031
1908	Vascular cell adhesion protein 1	VCAM1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6432	Transporter	snf	0.0031
172	Potassium channel subfamily K member 1	KCNK1	0.003
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
6645	D-amino-acid oxidase	DAO	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.003
173	Toll-like receptor 7	TLR7	0.003
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.003
2300	Lysozyme	E	0.003
3633	Lysozyme	R	0.003
5597	Lysozyme	17	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
2112	Toll-like receptor 9	TLR9	0.0029
822	Aldose reductase	AKR1B1	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0029
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0029
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0029
672	Prostaglandin F2-alpha receptor	PTGFR	0.0028
1039	Histone deacetylase 9	HDAC9	0.0028
2021	Thrombomodulin	THBD	0.0028
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0028
161	Tubulin beta chain	TUBB	0.0028
312	Tubulin beta chain	TUB2	0.0028
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0028
5126	Arginase	rocF	0.0027
76	Nitric-oxide synthase, brain	NOS1	0.0027
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0027
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0027
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0027
284	DNA-directed RNA polymerase beta chain	rpoB	0.0027
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1654	Interleukin-1 beta	IL1B	0.0026
2320	Thymidine kinase, cytosolic	TK1	0.0026
6171	Solute carrier family 28 member 3	SLC28A3	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
85	Growth hormone receptor	GHR	0.0025
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0025
740	Argininosuccinate synthase	ASS1	0.0025
865	Argininosuccinate synthase	ASS1	0.0025
2680	Argininosuccinate synthase	argG	0.0025
3194	Argininosuccinate synthase	argG	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
244	Angiotensin-converting enzyme	ACE	0.0025
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0025
1541	Metalloproteinase	mmp20	0.0025
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0025
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0025
5095	Putidaredoxin reductase	camA	0.0025
526	Thioredoxin reductase	trxB	0.0025
3767	Thioredoxin reductase	trxB	0.0025
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0025
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0025
5122	Mersacidin decarboxylase	mrsD	0.0025
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0025
5115	FkbI	fkbI	0.0025
3133	UDP-galactopyranose mutase	glf	0.0025
5099	UDP-galactopyranose mutase	glf	0.0025
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0025
5083	Cryptochrome DASH	cry	0.0025
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0025
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0025
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0025
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0025
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0025
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0025
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0025
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0025
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0025
5081	L-aspartate oxidase	nadB	0.0025
5111	Phenylacetone monooxygenase	pamO	0.0025
5109	Outer membrane protein p64k or PM-6	m-6	0.0025
663	Solute carrier family 12 member 4	SLC12A4	0.0024
53	Solute carrier family 12 member 5	SLC12A5	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
6070	Nischarin	NISCH	0.0024
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0024
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0024
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0024
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0024
6174	50S ribosomal protein L32	rpmF	0.0024
1196	Complement decay-accelerating factor	CD55	0.0023
6218	Pannexin-1	PANX1	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0023
310	Solute carrier family 12 member 2	SLC12A2	0.0023
4486	Phenol 2-hydroxylase component B	pheA2	0.0023
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0023
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0023
5117	Dihydrolipoyl dehydrogenase	lpd	0.0023
4439	Ferredoxin reductase	bphA4	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
394	Calcineurin subunit B isoform 1	PPP3R1	0.0022
6742	Recoverin	RCVRN	0.0022
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
2528	Fatty acid metabolism regulator protein	fadR	0.0022
6740	Fatty acid metabolism regulator protein	fadR	0.0022
6753	Apolipoprotein M	APOM	0.0022
6747	Chalcone/stilbene synthase family protein	MT1417	0.0022
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0022
6743	Non-fluorescent flavoprotein	luxF	0.0022
6751	Gag polyprotein	gag	0.0022
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0022
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0022
2539	Tubulin alpha-1 chain	TUBA4A	0.0022
6749	Polyprotein	Not Available	0.0022
494	Caspase-1	CASP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0022
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0022
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0021
5073	Ferredoxin--NADP reductase	petH	0.0021
5076	Ferredoxin--NADP reductase	fpr	0.0021
5119	Ferredoxin--NADP reductase	petH	0.0021
5121	Ferredoxin--NADP reductase	fpr	0.0021
2526	NADPH-ferredoxin reductase fprA	fprA	0.0021
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0021
3102	Flavohemoprotein	hmp	0.0021
4969	Flavohemoprotein	hmp	0.0021
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0021
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0021
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0021
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0021
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0021
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0021
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0021
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0021
5072	N,N-dimethylglycine oxidase	dmg	0.0021
2470	Pyruvate oxidase	pox5	0.0021
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0021
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0021
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0021
2268	Cholesterol oxidase	choB	0.0021
2822	Cholesterol oxidase	choA	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
5300	Antigen peptide transporter 1	TAP1	0.0021
1050	Bile salt sulfotransferase	SULT2A1	0.0021
6042	Prostaglandin reductase 2	PTGR2	0.0021
3587	Gastrotropin	FABP6	0.002
4440	NADH peroxidase	npr	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
2808	Chloramphenicol acetyltransferase 3	cat3	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.002
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.002
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.002
5961	Insulin	INS	0.002
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.002
2893	Glycine oxidase	thiO	0.0019
627	11-cis retinol dehydrogenase	RDH5	0.0019
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0019
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0019
1792	Tissue-type plasminogen activator	PLAT	0.0019
6755	Poliovirus receptor	PVR	0.0019
6527	Lymphocyte antigen 96	LY96	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0019
2567	Thymidylate synthase thyX	thyX	0.0019
327	Glutathione reductase	gor	0.0019
5110	Glutathione reductase	GR2	0.0019
2417	Chloramphenicol acetyltransferase	cat	0.0018
3278	Chloramphenicol acetyltransferase	cat	0.0018
2823	Trypanothione reductase	TPR	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
126	D-lactate dehydrogenase	dld	0.0018
3545	D-lactate dehydrogenase	Not Available	0.0018
4510	D-lactate dehydrogenase	ldhA	0.0018
2077	Caspase-3	CASP3	0.0018
1253	Interferon gamma	IFNG	0.0018
2810	Dr hemagglutinin structural subunit	draA	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0018
2769	P-hydroxybenzoate hydroxylase	pobA	0.0018
2809	P-hydroxybenzoate hydroxylase	pobA	0.0018
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
6750	ADP-ribosylation factor 6	ARF6	0.0018
6524	Protein tonB	tonB	0.0018
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0018
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0018
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0018
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0018
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
819	Penicillin-binding protein 4	dacB	0.0017
828	Phenylalanine-4-hydroxylase	PAH	0.0017
3109	Phenylalanine-4-hydroxylase	phhA	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
1864	RET proto-oncogene	RET	0.0017
6131	Carbonic anhydrase 14	CA14	0.0017
2380	Monomeric sarcosine oxidase	soxA	0.0017
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0017
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0017
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0017
2616	Ganglioside GM2 activator	GM2A	0.0017
1830	5'-nucleotidase	NT5E	0.0016
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
319	Opioid receptor, sigma 1	OPRS1	0.0016
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0016
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0016
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0016
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0016
1243	Cathepsin D	CTSD	0.0016
1313	Lactoylglutathione lyase	GLO1	0.0016
6122	Carbonic anhydrase 3	CA3	0.0016
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0016
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
1630	Integrin beta-2	ITGB2	0.0015
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0015
2297	Genome polyprotein	Not Available	0.0015
2322	Genome polyprotein	Not Available	0.0015
2694	Genome polyprotein	Not Available	0.0015
2719	Genome polyprotein	Not Available	0.0015
2860	Genome polyprotein	Not Available	0.0015
2928	Genome polyprotein	Not Available	0.0015
3160	Genome polyprotein	Not Available	0.0015
3260	Genome polyprotein	Not Available	0.0015
4783	Genome polyprotein	Not Available	0.0015
5726	Genome polyprotein	Not Available	0.0015
5779	Genome polyprotein	Not Available	0.0015
5867	Genome polyprotein	Not Available	0.0015
6253	Genome polyprotein	Not Available	0.0015
6301	Genome polyprotein	Not Available	0.0015
6380	Genome polyprotein	Not Available	0.0015
6381	Genome polyprotein	Not Available	0.0015
6437	Genome polyprotein	Not Available	0.0015
6520	Genome polyprotein	Not Available	0.0015
6521	Genome polyprotein	Not Available	0.0015
6652	Genome polyprotein	Not Available	0.0015
6734	Genome polyprotein	Not Available	0.0015
6735	Genome polyprotein	Not Available	0.0015
6736	Genome polyprotein	Not Available	0.0015
6737	Genome polyprotein	Not Available	0.0015
6738	Genome polyprotein	Not Available	0.0015
6739	Genome polyprotein	Not Available	0.0015
6744	Genome polyprotein	Not Available	0.0015
6748	Genome polyprotein	Not Available	0.0015
6894	Genome polyprotein	Not Available	0.0015
6898	Genome polyprotein	Not Available	0.0015
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0015
6316	ADP-ribosylation factor 1	ARF1	0.0015
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
864	Gag-Pol polyprotein	gag-pol	0.0014
2237	Gag-Pol polyprotein	gag-pol	0.0014
2326	Gag-Pol polyprotein	gag-pol	0.0014
2451	Gag-Pol polyprotein	gag-pol	0.0014
2901	Gag-Pol polyprotein	gag-pol	0.0014
3165	Gag-Pol polyprotein	gag-pol	0.0014
3722	Gag-Pol polyprotein	gag-pol	0.0014
6306	Gag-Pol polyprotein	gag-pol	0.0014
6624	Gag-Pol polyprotein	gag-pol	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
2091	Endoplasmin	HSP90B1	0.0014
174	Sigma 1-type opioid receptor	SIGMAR1	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
165	FL cytokine receptor	FLT3	0.0013
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0013
6103	Arylamine N-acetyltransferase 1	NAT1	0.0013
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
768	FK506-binding protein 1A	FKBP1A	0.0012
2427	Ferrichrome-iron receptor	fhuA	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0012
5818	Folate receptor alpha	FOLR1	0.0012
572	Integrin alpha-L	ITGAL	0.0012
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0011
5798	Mitogen-activated protein kinase 11	MAPK11	0.0011
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
2391	Ferrochelatase	hemH	0.0011
6502	Ferrochelatase	DKFZp686P18130	0.0011
1591	Ferrochelatase, mitochondrial	FECH	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0011
2408	Tyrosine-protein kinase SYK	SYK	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
816	Biliverdin reductase A	BLVRA	0.0011
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0011
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0011
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0011
4237	50S ribosomal protein L22	rplV	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
646	Malate dehydrogenase, cytoplasmic	MDH1	0.001
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.001
1360	Sphingomyelin phosphodiesterase	SMPD1	0.001
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.001
328	Sorbitol dehydrogenase	SORD	0.001
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.001
666	NADP-dependent malic enzyme	ME1	0.001
597	Dihydropteridine reductase	QDPR	0.001
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.001
396	Alcohol dehydrogenase 4	ADH4	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
345	Plasma retinol-binding protein	RBP4	0.001
6138	Multidrug resistance protein 3	ABCB4	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.001
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.001
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.001
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.001
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.001
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.001
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.001
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.001
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.001
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.001
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.001
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.001
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.001
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.001
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.001
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.001
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.001
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.001
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.001
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.001
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.001
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.001
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.001
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.001
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.001
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.001
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.001
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.001
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.001
107	C-4 methylsterol oxidase	SC4MOL	0.001
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.001
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.001
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.001
711	UDP-glucose 6-dehydrogenase	UGDH	0.001
3672	UDP-glucose 6-dehydrogenase	hasB	0.001
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.001
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.001
167	L-lactate dehydrogenase C chain	LDHC	0.001
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.001
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.001
206	3-keto-steroid reductase	HSD17B7	0.001
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.001
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.001
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.001
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.001
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.001
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.001
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.001
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.001
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.001
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.001
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.001
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.001
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.001
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.001
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.001
34	7-dehydrocholesterol reductase	DHCR7	0.001
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.001
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.001
3726	D-3-phosphoglycerate dehydrogenase	serA	0.001
4291	D-3-phosphoglycerate dehydrogenase	serA	0.001
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.001
644	Heme oxygenase 2	HMOX2	0.001
4982	Heme oxygenase 2	pbsA2	0.001
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.001
729	GDP-L-fucose synthetase	TSTA3	0.001
3463	GDP-L-fucose synthetase	fcl	0.001
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.001
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.001
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.001
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.001
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.001
643	Peroxisomal bifunctional enzyme	EHHADH	0.001
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.001
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.001
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.001
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.001
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.001
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.001
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.001
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.001
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.001
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.001
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.001
6493	Cytochrome c oxidase subunit 6C	COX6C	0.001
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.001
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.001
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.001
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.001
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.001
6559	Cytochrome c oxidase subunit 2	ctaC	0.001
6669	Cytochrome c oxidase subunit 2	ctaC	0.001
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.001
371	Cytochrome c oxidase subunit 1	MT-CO1	0.001
6558	Cytochrome c oxidase subunit 1	ctaD	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
77	L-lactate dehydrogenase B chain	LDHB	0.001
12	Alcohol dehydrogenase class 3	ADH5	0.001
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0009
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0009
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0009
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0009
473	L-lactate dehydrogenase A chain	LDHA	0.0009
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0009
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
1650	Heme carrier protein 1	SLC46A1	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0009
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0009
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0009
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
2540	Choloylglycine hydrolase	cbh	0.0009
13	Aminomethyltransferase, mitochondrial	AMT	0.0009
5787	Angiopoietin-1 receptor	TEK	0.0009
810	Heme oxygenase 1	HMOX1	0.0009
3391	Heme oxygenase 1	pbsA1	0.0009
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0009
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0009
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0009
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0008
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0008
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0008
6501	Fatty acid-binding protein, liver	FABP1	0.0008
6026	Alcohol dehydrogenase 6	ADH6	0.0008
654	Flavin reductase	BLVRB	0.0008
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0008
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0008
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0008
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0008
626	Cysteine dioxygenase type 1	CDO1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
735	Alanine aminotransferase 1	GPT	0.0008
3904	Alanine aminotransferase 2	GPT2	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
4773	Deoxycytidine kinase	DCK	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
4948	Cytochrome c-553	Not Available	0.0007
4923	Cytochrome c3	DvMF_2499	0.0007
4945	Cytochrome c3	Not Available	0.0007
4949	Cytochrome c3	DVU_3171	0.0007
4968	Cytochrome c3	cytc3	0.0007
4997	Cytochrome c3	SO_2727	0.0007
5219	Cytochrome c3	cyd	0.0007
4902	Nine-heme cytochrome c	Ddes_2038	0.0007
3189	High-molecular-weight cytochrome c	hmcA	0.0007
279	Tyrosinase	TYR	0.0007
6500	Phospholipase A2	PLA2G1B	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0006
3221	Cytochrome c4	cc4	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
760	Fibroblast growth factor 1	FGF1	0.0005
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0005
1268	Neuropeptide S receptor	NPSR1	0.0005
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0005
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0004
2207	Rhodopsin	RHO	0.0003
4954	Soluble cytochrome b558	Not Available	0.0002
4916	Cyanoglobin	glbN	0.0002
4934	Cytochrome c-551	nirM	0.0002
5218	Cytochrome c-551	nirM	0.0002
4947	Bacterial hemoglobin	vhb	0.0002
4915	Cytochrome c-550	psbV	0.0002
4959	Cytochrome c-550	psbV	0.0002
5216	Cytochrome c-550	psbV	0.0002
4925	Cytochrome c-type protein SHP	shp	0.0002
4998	Hemoglobin-like protein yjbI	yjbI	0.0002
4905	Cytochrome c2	Not Available	0.0002
4939	Cytochrome c2	cycA	0.0002
4964	Cytochrome c2	cycA	0.0002
4979	Cytochrome c2	cycA	0.0002
6673	Cytochrome c2	cycA	0.0002
5000	HemO	hemO	0.0002
4975	Cytochrome c-556	RPA3973	0.0002
4984	Neuroglobin	NGB	0.0002
4943	Cytochrome c6	petJ	0.0002
4910	Cytoglobin	CYGB	0.0002
4907	Cytochrome c-L	moxG	0.0002
6865	Cytochrome c-L	moxG	0.0002
4981	Iron-starvation protein PigA	pigA	0.0002
4971	Nonaheme cytochrome c	hmcA	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0002
4909	CooA protein	cooA	0.0002
4994	Hemoglobin-like protein HbO	glbO	0.0002
4935	Cytochrome c-554	cycA1	0.0002
4942	Diheme cytochrome c napB	napB	0.0002
3116	Bacterioferritin	bfr	0.0002
4906	Bacterioferritin	bfr	0.0002
4965	Bacterioferritin	bfr	0.0002
4922	Cytochrome c, putative	SO_4144	0.0002
4764	Cytochrome P450 165C4	CYP165C4	0.0002
4937	Cytochrome oxidase subunit II	rcoxA	0.0002
4989	Cytochrome c551 peroxidase	ccp	0.0002
5222	Cytochrome c551 peroxidase	ccpA	0.0002
4961	Hemophore HasA	hasA	0.0002
4976	Apocytochrome f	petA	0.0002
6407	Apocytochrome f	petA	0.0002
4904	Cytochrome c family protein	GSU1996	0.0002
4903	Methyl-accepting chemotaxis protein	Tar4	0.0002
4999	Cytochrome P450 165B3	CYP165B3	0.0002
4960	Putative cytochrome P450-family protein	SCO7417	0.0002
4931	Cytochrome P450 167A1	CYP167A1	0.0002
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0002
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0002
4993	Hydroxylamine oxidoreductase	hao1	0.0002
4972	P450cin	cinA	0.0002
3093	Catalase HPII	katE	0.0002
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0002
4952	Catalase/peroxidase	katA	0.0002
4920	Peroxidase/catalase	katG	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
4990	PpcA	ppcA	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01065 - Melatonin

Targets

Enzymes

Transporters

Predictions