DT-Web

DB00316 - Acetaminophen


Identification
Name Acetaminophen
Accession Number DB00316 (APRD00252)
Type small molecule
Description Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 151.1626
Groups approved
Monoisotopic Weight 151.063328537
Pharmacology
Indication For temporary relief of fever, minor aches, and pains.
Mechanism of action Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
Absorption Rapid and almost complete
Protein binding 25%
Biotransformation Acetaminophen primarily undergoes glucuronidation (45-55% of the dose) in which this process is facilitated by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver or UGT1A10 in the gut. 30-35% of the dose undergoes sulfation. This biotransformation is facilitated by SULT1A1, SULT1A3, SULT1A4, SULT1E1 and SULT2A1. A small percentage of acetaminophen is oxidized by CYP2E1 to form N-acetyl-p-benzo-quinone imine (NAPQI), a toxic metabolite which is then conjugated to glutathione and excreted renally. Studies suggest that CYP3A4 and CYP2E1 are the primary cytochrome P450 isozymes responsible for the generation of toxic metabolites. Accumulation of NAPQI may occur if primary metabolic pathways are saturated.
Route of elimination Approximately 80% of acetaminophen is excreted in the urine after conjugation and about 3% is excreted unchanged.
Toxicity Oral, mouse: LD50 = 338 mg/kg; Oral, rat: LD50 = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with glucuronic acid and, to a lesser extent, sulfuric acid. Conjugates are then excreted by the kidneys. Only a small portion is excreted in unchanged in urine or oxidized via the hepatic cytochrome P450 enzyme system (CYP2E1). Metabolism via CYP2E1 produces a toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). The toxic effects of acetaminophen are due to NAPQI, not acetaminophen itself nor any of the major metabolites. At therapeutic doses, NAPQI reacts with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is excreted by the kidneys. High doses of acetaminophen may cause glutathione depletion, accumulation of NAPQI and hepatic necrosis. The maximum daily dose of acetaminophen is 4 g. Liver failure has been observed at doses as low as 6 g per day. As such, the maximum daily and single dose of acetaminophen is currently being reviewed in some countries. N-acetyl-cysteine, a precursor of glutathione, may be administered in the event of acetaminophen toxicity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Acetaminophen may increase the anticoagulant effect of acenocoumarol. Monitor for changes in the therapeutic and adverse effects of acenocoumarol if acetaminophen is initiated, discontinued or dose changed.
Anisindione Acetaminophen increases the anticoagulant effect of anisindione. Monitor for changes in the therapeutic and adverse effects of anisindione if acetaminophen is initiated, discontinued or dose changed.
Dicumarol Acetaminophen may increase the anticoagulant effect of dicumarol. Monitor for changes in the therapeutic and adverse effects of dicumarol if acetaminophen is initiated, discontinued or dose changed.
Eltrombopag Eltrombopag increases acetaminophen levels via decreasing metabolism. UDP-glucuronosyltransferase inhibition with unclear significance.
Imatinib Increased hepatic toxicity of both agents
Isoniazid Risk of hepatotoxicity
Liraglutide These agents may have decreased C max and a delayed T max during coadministration.
Warfarin Acetaminophen increases the anticoagulant effect of warfarin. Monitor for changes in the therapeutic and adverse effects of warfarin if acetaminophen is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol (may increase risk of hepatotoxicity).

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Lee YS, Kim H, Brahim JS, Rowan J, Lee G, Dionne RA: Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86. Epub 2006 Dec 18. - Pubmed
  • Hinz B, Cheremina O, Brune K: Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J. 2007 Sep 20;. - Pubmed
  • Weinheimer EM, Jemiolo B, Carroll CC, Harber MP, Haus JM, Burd NA, LeMoine JK, Trappe SW, Trappe TA: Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis. Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2241-8. Epub 2007 Feb 22. - Pubmed
DTHybrid score 0.6846
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8105

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
DTHybrid score 0.6837
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD: Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400. - Pubmed
DTHybrid score 0.4596
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD: Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400. - Pubmed
DTHybrid score 0.6644
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3985
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.46
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5928
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.839
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9574
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Bock KW, Forster A, Gschaidmeier H, Bruck M, Munzel P, Schareck W, Fournel-Gigleux S, Burchell B: Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Biochem Pharmacol. 1993 May 5;45(9):1809-14. - Pubmed
DTHybrid score 0.3408
UDP-glucuronosyltransferase 1-6
Name UDP-glucuronosyltransferase 1-6
Gene Name Not Available
Actions substrate
References
  • Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, Mackenzie PI: Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther. 2001 Dec;299(3):998-1006. - Pubmed
DTHybrid score Not Available
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, Mackenzie PI: Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther. 2001 Dec;299(3):998-1006. - Pubmed
DTHybrid score 0.4284
UDP-glucuronosyltransferase 2B15
Name UDP-glucuronosyltransferase 2B15
Gene Name Not Available
Actions substrate
References
  • Navarro SL, Chen Y, Li L, Li SS, Chang JL, Schwarz Y, King IB, Potter JD, Bigler J, Lampe JW: UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables. Drug Metab Dispos. 2011 Sep;39(9):1650-7. doi: 10.1124/dmd.111.039149. Epub 2011 Jun 10. - Pubmed
DTHybrid score Not Available
UDP-glucuronosyltransferase 1-10
Name UDP-glucuronosyltransferase 1-10
Gene Name UGT1A10
Actions substrate
References
  • Kiang TK, Ensom MH, Chang TK: UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther. 2005 Apr;106(1):97-132. Epub 2005 Jan 12. - Pubmed
DTHybrid score 0.1895
Sulfotransferase 1A1
Name Sulfotransferase 1A1
Gene Name SULT1A1
Actions substrate
References
  • Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS: Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65. doi: 10.1002/bdra.20535. - Pubmed
DTHybrid score 0.4031
Sulfotransferase 1A3/1A4
Name Sulfotransferase 1A3/1A4
Gene Name Not Available
Actions substrate
References
  • Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS: Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65. doi: 10.1002/bdra.20535. - Pubmed
DTHybrid score Not Available
Estrogen sulfotransferase
Name Estrogen sulfotransferase
Gene Name SULT1E1
Actions substrate
References
  • Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS: Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65. doi: 10.1002/bdra.20535. - Pubmed
DTHybrid score 0.7684
Bile salt sulfotransferase
Name Bile salt sulfotransferase
Gene Name SULT2A1
Actions substrate
References
  • Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS: Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65. doi: 10.1002/bdra.20535. - Pubmed
DTHybrid score 0.6231
Arylamine N-acetyltransferase 2
Name Arylamine N-acetyltransferase 2
Gene Name NAT2
Actions inhibitor
References
  • Rothen JP, Haefeli WE, Meyer UA, Todesco L, Wenk M: Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9. - Pubmed
DTHybrid score 0.2151

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. - Pubmed
  • Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score 0.6424
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.4259

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.4977
4118 Cytochrome P450 3A5 CYP3A5 0.3318
6030 Cytochrome P450 2B6 CYP2B6 0.2882
587 Serum albumin ALB 0.275
6107 Cytochrome P450 3A7 CYP3A7 0.2415
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1883
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1699
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.1665
492 Histamine H1 receptor HRH1 0.1371
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1311
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1277
373 Transthyretin TTR 0.1275
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.1269
6142 Solute carrier family 22 member 8 SLC22A8 0.1243
6106 Cytochrome P450 2C18 CYP2C18 0.1144
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.1117
3317 Holo-[acyl-carrier-protein] synthase acpS 0.1108
4381 Holo-[acyl-carrier-protein] synthase acpS 0.1108
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.1106
862 Multidrug resistance-associated protein 1 ABCC1 0.1069
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1023
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1
4824 Dehydrogenase/reductase SDR family member 8 HSD17B11 0.0948
2390 Nonsecretory ribonuclease RNASE2 0.0943
1898 Cytochrome P450 1B1 CYP1B1 0.0941
3811 Cytochrome P450 19A1 CYP19A1 0.0887
1024 Solute carrier family 22 member 11 SLC22A11 0.0874
2164 Multidrug resistance-associated protein 4 ABCC4 0.0864
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0854
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0854
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0818
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0802
6143 Solute carrier family 22 member 7 SLC22A7 0.0801
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.078
824 Sodium-dependent serotonin transporter SLC6A4 0.0747
776 Bile salt export pump ABCB11 0.0726
275 Arachidonate 5-lipoxygenase ALOX5 0.0692
118 Organic cation/carnitine transporter 2 SLC22A5 0.0682
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0677
6145 Solute carrier family 22 member 1 SLC22A1 0.0663
1757 Myeloperoxidase MPO 0.065
831 D(2) dopamine receptor DRD2 0.0641
502 5-hydroxytryptamine 2A receptor HTR2A 0.0631
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0617
766 Beta-2 adrenergic receptor ADRB2 0.0613
6144 Solute carrier family 22 member 2 SLC22A2 0.0608
6307 Ig gamma-2 chain C region IGHG2 0.0608
556 Alpha-1A adrenergic receptor ADRA1A 0.0603
136 Estrogen receptor ESR1 0.0594
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0591
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0585
5682 Ribonuclease pancreatic RNASE1 0.0564
4604 Liver carboxylesterase 1 CES1 0.0559
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0557
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0551
847 Mu-type opioid receptor OPRM1 0.0549
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0544
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0544
467 Delta-type opioid receptor OPRD1 0.0509
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0503
696 Kappa-type opioid receptor OPRK1 0.0493
220 Sodium channel protein type 5 subunit alpha SCN5A 0.049
891 Dihydropteroate synthase folP 0.049
5359 Dihydropteroate synthase folP 0.049
7175 Dihydropteroate synthase sulI 0.049
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0485
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0483
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0483
2268 Cholesterol oxidase choB 0.0481
2822 Cholesterol oxidase choA 0.0481
6103 Arylamine N-acetyltransferase 1 NAT1 0.048
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.048
871 Glucocorticoid receptor NR3C1 0.0476
3810 Catechol O-methyltransferase COMT 0.0475
193 Beta-1 adrenergic receptor ADRB1 0.0466
318 Alpha-2A adrenergic receptor ADRA2A 0.0462
380 Cytochrome P450 17A1 CYP17A1 0.0452
2283 Steroid Delta-isomerase ksi 0.0446
2920 Steroid Delta-isomerase ksi 0.0446
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0442
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0442
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0441
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.044
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0439
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0434
3923 Cholinesterase BCHE 0.0434
590 5-hydroxytryptamine 2C receptor HTR2C 0.043
51 Muscarinic acetylcholine receptor M3 CHRM3 0.043
341 5-hydroxytryptamine 3 receptor HTR3A 0.0427
23 D(1A) dopamine receptor DRD1 0.0421
468 Cytochrome P450 4A11 CYP4A11 0.0417
3941 Amine oxidase [flavin-containing] A MAOA 0.0416
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0412
320 5-hydroxytryptamine 1A receptor HTR1A 0.0412
738 Monocarboxylate transporter 1 SLC16A1 0.041
817 DNA topoisomerase 2-alpha TOP2A 0.0406
6147 Solute carrier family 22 member 3 SLC22A3 0.0405
146 Androgen receptor AR 0.0389
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0384
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0379
713 Sodium-dependent dopamine transporter SLC6A3 0.0374
70 Type-1 angiotensin II receptor AGTR1 0.0372
777 Tumor necrosis factor TNF 0.0371
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0362
632 Alpha-1B adrenergic receptor ADRA1B 0.0362
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0358
404 DNA gyrase subunit A gyrA 0.0353
6224 DNA gyrase subunit A gyrA 0.0353
260 Cytochrome P450 51 ERG11 0.035
761 Cytochrome P450 51 ERG11 0.035
3163 Cytochrome P450 51 cyp51 0.035
518 Peroxidase/catalase T katG 0.0348
6014 Cytochrome P450 2A13 CYP2A13 0.0347
465 Calmodulin CALM1 0.0346
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0341
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.033
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0329
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0327
833 Organic cation/carnitine transporter 1 SLC22A4 0.0326
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0322
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0321
885 5-hydroxytryptamine 1B receptor HTR1B 0.032
6031 Cytochrome P450 3A43 CYP3A43 0.032
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0319
504 Mast/stem cell growth factor receptor KIT 0.0316
459 Retinoic acid receptor RXR-alpha RXRA 0.0314
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0313
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0308
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0307
3939 Amine oxidase [flavin-containing] B MAOB 0.0302
811 Translocator protein TSPO 0.0301
731 HIV-1 protease HIV-1 protease 0.0294
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0293
638 D(3) dopamine receptor DRD3 0.0292
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0289
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0287
3601 Dihydropteroate synthase 1 folP1 0.0284
3807 Dihydropteroate synthase 1 folP1 0.0284
3808 Dihydropteroate synthase 2 folP2 0.0284
723 Cytosolic phospholipase A2 PLA2G4A 0.0284
869 Estrogen receptor beta ESR2 0.0283
6220 Aryl hydrocarbon receptor AHR 0.0281
477 DNA topoisomerase 4 subunit A parC 0.0281
886 DNA topoisomerase 4 subunit A parC 0.0281
6226 DNA topoisomerase 4 subunit A parC 0.0281
26 Vascular endothelial growth factor receptor 3 FLT4 0.028
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0279
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0279
6141 Sodium/bile acid cotransporter SLC10A1 0.0273
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0269
32 Vascular endothelial growth factor receptor 1 FLT1 0.0268
6148 Multidrug resistance-associated protein 7 ABCC10 0.0268
6026 Alcohol dehydrogenase 6 ADH6 0.0266
6136 Multidrug resistance-associated protein 5 ABCC5 0.0266
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0265
725 5-hydroxytryptamine 1D receptor HTR1D 0.0264
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0261
295 Carbonic anhydrase 1 CA1 0.0261
789 Alpha-1D adrenergic receptor ADRA1D 0.026
36 Insulin receptor INSR 0.0258
6137 Multidrug resistance-associated protein 6 ABCC6 0.0255
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0255
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0255
407 Vascular endothelial growth factor receptor 2 KDR 0.0254
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0254
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0254
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0245
592 Carbonic anhydrase 4 CA4 0.0242
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0242
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.024
3947 Xanthine dehydrogenase/oxidase XDH 0.024
629 Alpha-2B adrenergic receptor ADRA2B 0.0239
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0237
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0237
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0233
228 Beta platelet-derived growth factor receptor PDGFRB 0.0232
844 Epidermal growth factor receptor EGFR 0.0231
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.023
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.023
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.023
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.023
122 P2Y purinoceptor 12 P2RY12 0.0229
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0227
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0227
6043 Putative G-protein coupled receptor 44 GPR44 0.0218
6182 Cytochrome P450 2J2 CYP2J2 0.0216
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0214
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0213
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0212
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0212
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0212
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0212
436 5-hydroxytryptamine 2B receptor HTR2B 0.0212
378 Alpha-2C adrenergic receptor ADRA2C 0.021
16 Adenosine A1 receptor ADORA1 0.0209
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0209
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0207
614 Progesterone receptor PGR 0.0207
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0207
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0205
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0203
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0203
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0203
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0203
6085 Fatty acid-binding protein, intestinal FABP2 0.0199
3312 Fatty acid-binding protein, brain FABP7 0.0199
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0198
3809 Estrogen-related receptor gamma ESRRG 0.0198
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0197
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0195
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0195
4132 Chloride channel protein ClC-Ka CLCNKA 0.0194
267 Plasminogen activator inhibitor 1 SERPINE1 0.0194
1178 Adenosine A2a receptor ADORA2A 0.0192
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0192
357 Carbonic anhydrase 2 CA2 0.0191
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0188
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0188
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0187
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0186
1159 Interleukin-6 IL6 0.0185
1039 Histone deacetylase 9 HDAC9 0.0184
432 D(4) dopamine receptor DRD4 0.0182
823 Fibroblast growth factor receptor 2 FGFR2 0.0181
613 Atrial natriuretic peptide receptor A NPR1 0.0179
3932 Glutathione S-transferase A2 GSTA2 0.0178
5880 Thrombopoietin receptor MPL 0.0178
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0176
482 Glycine receptor subunit alpha-1 GLRA1 0.0176
6221 Steroid hormone receptor ERR1 ESRRA 0.0176
232 Corticosteroid-binding globulin SERPINA6 0.0175
1010 Cytochrome P450 51A1 CYP51A1 0.0171
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0171
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0171
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.017
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0169
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0169
633 Penicillin-binding proteins 1A/1B pbpA 0.0169
185 Vasopressin V1a receptor AVPR1A 0.0167
322 Vasopressin V2 receptor AVPR2 0.0163
6126 Carbonic anhydrase 7 CA7 0.0162
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0162
94 5-hydroxytryptamine 4 receptor HTR4 0.0162
319 Opioid receptor, sigma 1 OPRS1 0.0161
716 5-hydroxytryptamine 7 receptor HTR7 0.016
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0158
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0158
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0157
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0157
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0157
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0157
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0155
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0155
672 Prostaglandin F2-alpha receptor PTGFR 0.0155
737 Mineralocorticoid receptor NR3C2 0.0154
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0154
4122 Histone deacetylase 2 HDAC2 0.0153
474 Acetylcholinesterase ACHE 0.0153
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0151
2449 Tubulin alpha-3 chain TUBA1A 0.0148
558 Solute carrier family 12 member 1 SLC12A1 0.0148
3639 Thymidine phosphorylase deoA 0.0147
3936 Thymidine phosphorylase TYMP 0.0147
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0146
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0145
1648 Elastin ELN 0.0145
2499 Tubulin beta-2C chain TUBB2C 0.0144
273 Apoptosis regulator Bcl-2 BCL2 0.0143
489 Monocarboxylate transporter 2 SLC16A7 0.0142
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0142
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0141
952 Dipeptidyl peptidase 4 DPP4 0.014
365 Dihydrofolate reductase DHFR 0.0138
2381 Dihydrofolate reductase DFR1 0.0138
2833 Dihydrofolate reductase Not Available 0.0138
2931 Dihydrofolate reductase folA 0.0138
3544 Dihydrofolate reductase folA 0.0138
3682 Dihydrofolate reductase folA 0.0138
6642 Dihydrofolate reductase folA 0.0138
6756 Dihydrofolate reductase dfrA 0.0138
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0138
537 ATP synthase delta chain, mitochondrial ATP5D 0.0138
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0138
124 Histamine H2 receptor HRH2 0.0138
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0138
1656 CYP2B protein CYP2B 0.0138
705 Glutamate receptor 1 GRIA1 0.0137
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0136
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0135
130 Prostacyclin synthase PTGIS 0.0134
1714 Mitogen-activated protein kinase 3 MAPK3 0.0133
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0133
2981 Phospholipase A2, membrane associated PLA2G2A 0.0133
68 Cannabinoid receptor 1 CNR1 0.0132
1507 Cytochrome c CYCS 0.0132
703 NADPH azoreductase azr 0.0132
24 Thymidylate synthase TMP1 0.0132
359 Thymidylate synthase TYMS 0.0132
2626 Thymidylate synthase thyA 0.0132
2729 Thymidylate synthase thyA 0.0132
5352 Thymidylate synthase THYA 0.0132
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
1517 Beta-3 adrenergic receptor ADRB3 0.013
161 Tubulin beta chain TUBB 0.013
312 Tubulin beta chain TUB2 0.013
790 DNA polymerase subunit alpha B POLA2 0.0129
4120 NADPH--cytochrome P450 reductase POR 0.0128
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0128
338 DNA polymerase UL30 0.0128
379 DNA polymerase UL54 0.0128
697 DNA polymerase ORF28 0.0128
2482 DNA polymerase 43 0.0128
4104 DNA polymerase BALF5 0.0128
756 Sex hormone-binding globulin SHBG 0.0128
904 Glutathione S-transferase P GSTP1 0.0127
4237 50S ribosomal protein L22 rplV 0.0127
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0126
1629 Transcription factor AP-1 JUN 0.0125
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0124
54 Prothrombin F2 0.0123
6500 Phospholipase A2 PLA2G1B 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
1353 DNA topoisomerase 1 TOP1 0.0121
3552 DNA topoisomerase 1 topA 0.0121
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0121
29 Tubulin beta-1 chain TUBB1 0.0121
3917 Methylenetetrahydrofolate reductase MTHFR 0.012
2021 Thrombomodulin THBD 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0118
2230 Catalase CAT 0.0117
3249 Catalase katA 0.0117
3625 Catalase katA 0.0117
4539 Catalase katA 0.0117
4941 Catalase katB 0.0117
4238 50S ribosomal protein L4 rplD 0.0117
5578 50S ribosomal protein L4 rplD 0.0117
6173 50S ribosomal protein L4 rplD 0.0117
6219 50S ribosomal protein L4 rplD 0.0117
251 Alcohol dehydrogenase 1A ADH1A 0.0117
33 Cystine/glutamate transporter SLC7A11 0.0116
908 Glutathione S-transferase theta-1 GSTT1 0.0116
3937 Fatty-acid amide hydrolase FAAH 0.0116
48 Pyridoxal kinase PDXK 0.0116
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0115
818 50S ribosomal protein L10 rplJ 0.0115
163 D(1B) dopamine receptor DRD5 0.0115
4203 Histamine N-methyltransferase HNMT 0.0114
444 Alcohol dehydrogenase 1B ADH1B 0.0114
1618 High affinity nerve growth factor receptor NTRK1 0.0114
6149 Solute carrier family 22 member 10 SLC22A10 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
244 Angiotensin-converting enzyme ACE 0.0112
3823 Cytokine receptor common gamma chain IL2RG 0.0112
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0112
528 5-hydroxytryptamine 1E receptor HTR1E 0.0112
921 Glutamate receptor 2 GRIA2 0.0111
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
106 Cannabinoid receptor 2 CNR2 0.0109
2112 Toll-like receptor 9 TLR9 0.0108
427 Substance-P receptor TACR1 0.0108
645 Penicillin-binding protein 1A mrcA 0.0107
5805 Penicillin-binding protein 1A ponA 0.0107
6185 Penicillin-binding protein 1A mrcA 0.0107
6799 Penicillin-binding protein 1A pbpA 0.0107
6146 High affinity copper uptake protein 1 SLC31A1 0.0107
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0107
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0106
6766 O-GlcNAcase BT_4395 BT_4395 0.0105
571 Melatonin receptor type 1A MTNR1A 0.0104
362 Melatonin receptor type 1B MTNR1B 0.0104
2183 Fatty acid-binding protein, adipocyte FABP4 0.0103
4192 DNA topoisomerase 2-beta TOP2B 0.0103
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0103
6033 High affinity interleukin-8 receptor A CXCR1 0.0102
6020 Aldehyde oxidase AOX1 0.0101
511 5-hydroxytryptamine 1F receptor HTR1F 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
634 Squalene monooxygenase SQLE 0.0099
7196 Squalene monooxygenase ERG1 0.0099
4221 Vascular endothelial growth factor VEGF 0.0099
183 Vascular endothelial growth factor A VEGFA 0.0099
5816 Cadherin-5 CDH5 0.0099
1256 5-hydroxytryptamine 6 receptor HTR6 0.0099
7 Nitric oxide synthase, inducible NOS2 0.0099
131 Synaptic vesicular amine transporter SLC18A2 0.0098
1439 Lactotransferrin LTF 0.0098
165 FL cytokine receptor FLT3 0.0098
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0098
724 Interleukin-2 receptor alpha chain IL2RA 0.0097
717 Interleukin-2 receptor subunit beta IL2RB 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0097
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0097
814 Ryanodine receptor 1 RYR1 0.0096
2236 Casein kinase II subunit alpha CSNK2A1 0.0095
2320 Thymidine kinase, cytosolic TK1 0.0095
284 DNA-directed RNA polymerase beta chain rpoB 0.0095
5773 DNA-directed RNA polymerase beta chain rpoB 0.0095
3856 Fibroblast growth factor receptor 3 FGFR3 0.0094
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0094
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0094
88 Retinoic acid receptor RXR-beta RXRB 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0092
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0092
517 Alcohol dehydrogenase 1C ADH1C 0.0092
936 Ephrin type-A receptor 2 EPHA2 0.0091
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0091
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0091
4103 Proteasome subunit beta type 2 PSMB2 0.009
4102 Proteasome subunit beta type 5 PSMB5 0.009
4101 Proteasome subunit beta type 1 PSMB1 0.009
84 Nuclear receptor 0B1 NR0B1 0.009
117 Sterol O-acyltransferase 1 SOAT1 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
1650 Heme carrier protein 1 SLC46A1 0.0086
6131 Carbonic anhydrase 14 CA14 0.0086
5787 Angiopoietin-1 receptor TEK 0.0086
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0085
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0085
6044 Serum paraoxonase/lactonase 3 PON3 0.0085
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0085
563 Thyroid peroxidase TPO 0.0084
6042 Prostaglandin reductase 2 PTGR2 0.0084
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0084
4311 tRNA TRDMT1 0.0084
4325 tRNA trmD 0.0084
4328 tRNA trmD 0.0084
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0083
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0083
1792 Tissue-type plasminogen activator PLAT 0.0083
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0083
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0083
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
5798 Mitogen-activated protein kinase 11 MAPK11 0.0082
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
780 Retinoic acid receptor RXR-gamma RXRG 0.0079
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0079
173 Toll-like receptor 7 TLR7 0.0079
239 Coagulation factor X F10 0.0079
5626 Nucleoside diphosphate kinase B NME2 0.0078
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0077
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
1374 Natriuretic peptides B NPPB 0.0076
820 Glycine receptor subunit alpha-2 GLRA2 0.0076
1827 Gap junction alpha-1 protein GJA1 0.0076
1908 Vascular cell adhesion protein 1 VCAM1 0.0076
1541 Metalloproteinase mmp20 0.0074
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0074
65 Matrix metalloproteinase-9 Not Available 0.0074
6174 50S ribosomal protein L32 rpmF 0.0073
822 Aldose reductase AKR1B1 0.0072
976 Platelet glycoprotein IX GP9 0.0072
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0071
1630 Integrin beta-2 ITGB2 0.007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.007
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0069
828 Phenylalanine-4-hydroxylase PAH 0.0069
3109 Phenylalanine-4-hydroxylase phhA 0.0069
49 Endothelin B receptor EDNRB 0.0069
291 Nitric-oxide synthase, endothelial NOS3 0.0069
6432 Transporter snf 0.0068
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0068
162 Retinoic acid receptor gamma-1 RARG 0.0068
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0068
469 Annexin A1 ANXA1 0.0068
1636 Trace amine-associated receptor 1 TAAR1 0.0067
856 Vitamin D3 receptor VDR 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
661 ADP/ATP translocase 1 SLC25A4 0.0067
527 Prostacyclin receptor PTGIR 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0065
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0065
1313 Lactoylglutathione lyase GLO1 0.0065
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0065
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0064
3957 Adenosine deaminase ADA 0.0064
1820 Beta-nerve growth factor NGF 0.0064
2298 Cytochrome P450-cam camC 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
5294 Nucleoside diphosphate kinase A NME1 0.0063
133 Dihydropterate synthase sulI 0.0063
6122 Carbonic anhydrase 3 CA3 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
5934 Cytochrome P450 26A1 CYP26A1 0.0062
4773 Deoxycytidine kinase DCK 0.0062
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0062
1760 Aminopeptidase N ANPEP 0.0061
6843 Aminopeptidase N pepN 0.0061
3426 Glutamine synthetase glnA 0.0061
3987 Glutamine synthetase GLUL 0.0061
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.006
581 Cytochrome P450 2R1 CYP2R1 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
4217 Telomerase reverse transcriptase TERT 0.0059
4692 A/G-specific adenine glycosylase mutY 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0058
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0058
164 Histamine H4 receptor HRH4 0.0057
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0057
400 Coagulation factor IX F9 0.0057
5461 Coagulation factor IX F9 0.0057
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0057
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0057
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0056
174 Sigma 1-type opioid receptor SIGMAR1 0.0056
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0055
6506 Stathmin-4 STMN4 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0054
569 Retinal dehydrogenase 2 ALDH1A2 0.0054
268 Adenosine A2b receptor ADORA2B 0.0054
3007 Carbonic anhydrase 12 CA12 0.0054
4205 Carbonic anhydrase 9 CA9 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
1852 Microtubule-associated protein 2 MAP2 0.0053
2207 Rhodopsin RHO 0.0053
572 Integrin alpha-L ITGAL 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
1196 Complement decay-accelerating factor CD55 0.0053
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0052
604 Vitamin K-dependent protein Z PROZ 0.0052
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0052
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0052
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0052
712 Tubulin alpha chain TUB1 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2539 Tubulin alpha-1 chain TUBA4A 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
611 Retinal dehydrogenase 1 ALDH1A1 0.0051
5300 Antigen peptide transporter 1 TAP1 0.005
6167 Organic solute transporter subunit beta OSTB 0.0049
6166 Organic solute transporter subunit alpha OSTA 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
3404 Exotoxin A eta 0.0049
760 Fibroblast growth factor 1 FGF1 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
422 Vitamin K-dependent protein C PROC 0.0048
1245 Vitamin K-dependent protein S PROS1 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
6163 Copper-transporting ATPase 2 ATP7B 0.0048
6165 Copper-transporting ATPase 1 ATP7A 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0047
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
707 72 kDa type IV collagenase MMP2 0.0047
1992 Vitamin D-binding protein GC 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
751 Potassium channel subfamily K member 6 KCNK6 0.0046
896 Glutathione S-transferase Mu 1 GSTM1 0.0046
2808 Chloramphenicol acetyltransferase 3 cat3 0.0046
293 Gamma-glutamyl hydrolase GGH 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
3086 Plasmepsin-2 Not Available 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0044
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0044
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0044
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0044
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0044
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0044
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0044
663 Solute carrier family 12 member 4 SLC12A4 0.0044
53 Solute carrier family 12 member 5 SLC12A5 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
172 Potassium channel subfamily K member 1 KCNK1 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
2417 Chloramphenicol acetyltransferase cat 0.0042
3278 Chloramphenicol acetyltransferase cat 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0042
2810 Dr hemagglutinin structural subunit draA 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0041
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
408 Riboflavin kinase RFK 0.0041
229 Retinoic acid receptor beta RARB 0.0041
310 Solute carrier family 12 member 2 SLC12A2 0.0041
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
718 Folate receptor gamma FOLR3 0.004
299 Folate receptor beta FOLR2 0.004
3679 MTA/SAH nucleosidase mtnN 0.004
804 Mitochondrial folate transporter/carrier SLC25A32 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
4225 Uridine phosphorylase 1 UPP1 0.0039
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0039
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
798 Osteocalcin BGLAP 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
128 Adenine phosphoribosyltransferase APRT 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0037
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0036
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0036
1867 Major prion protein PRNP 0.0036
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
2408 Tyrosine-protein kinase SYK SYK 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
369 Coagulation factor VII F7 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1864 RET proto-oncogene RET 0.0035
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0034
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0034
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0034
3830 Calreticulin CALR 0.0034
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0034
1063 Signal transducer and activator of transcription 5B STAT5B 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
6034 Hydroxyindole O-methyltransferase ASMT 0.0032
6035 Nuclear receptor ROR-beta RORB 0.0032
6036 Eosinophil peroxidase EPX 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
997 Protein kinase C beta type PRKCB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0031
6072 Potassium channel subfamily K member 3 KCNK3 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
6207 30S ribosomal protein S14 rpsN 0.0031
6209 30S ribosomal protein S19 rpsS 0.0031
6712 30S ribosomal protein S19 rpsS 0.0031
6726 30S ribosomal protein S19 rpsS 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
484 Tyrosine-protein kinase ABL2 ABL2 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
215 Sodium channel protein type 11 subunit alpha SCN11A 0.003
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
6100 BDNF/NT-3 growth factors receptor NTRK2 0.003
358 Cystathionine beta-synthase CBS 0.003
1970 Protein kinase C alpha type PRKCA 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
654 Flavin reductase BLVRB 0.0029
6048 Troponin C, skeletal muscle TNNC2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
6459 Glycodelin PAEP 0.0028
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
1253 Interferon gamma IFNG 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0028
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
765 Indoleamine 2,3-dioxygenase IDO1 0.0028
6218 Pannexin-1 PANX1 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
702 UMP-CMP kinase CMPK1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
3221 Cytochrome c4 cc4 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6859 Protein S100-A4 S100A4 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
3814 Complement C1r subcomponent C1R 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1341 Histamine H3 receptor HRH3 0.0023
4760 Mll3241 protein mll3241 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
2782 Complement C1s subcomponent C1S 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1243 Cathepsin D CTSD 0.0019
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0019
1654 Interleukin-1 beta IL1B 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
4948 Cytochrome c-553 Not Available 0.0016
4923 Cytochrome c3 DvMF_2499 0.0016
4945 Cytochrome c3 Not Available 0.0016
4949 Cytochrome c3 DVU_3171 0.0016
4968 Cytochrome c3 cytc3 0.0016
4997 Cytochrome c3 SO_2727 0.0016
5219 Cytochrome c3 cyd 0.0016
3189 High-molecular-weight cytochrome c hmcA 0.0016
4902 Nine-heme cytochrome c Ddes_2038 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
494 Caspase-1 CASP1 0.0015
6755 Poliovirus receptor PVR 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
6677 Myelin P2 protein PMP2 0.0015
3587 Gastrotropin FABP6 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
4943 Cytochrome c6 petJ 0.0013
4954 Soluble cytochrome b558 Not Available 0.0013
4934 Cytochrome c-551 nirM 0.0013
5218 Cytochrome c-551 nirM 0.0013
4905 Cytochrome c2 Not Available 0.0013
4939 Cytochrome c2 cycA 0.0013
4964 Cytochrome c2 cycA 0.0013
4979 Cytochrome c2 cycA 0.0013
6673 Cytochrome c2 cycA 0.0013
4925 Cytochrome c-type protein SHP shp 0.0013
4947 Bacterial hemoglobin vhb 0.0013
4916 Cyanoglobin glbN 0.0013
4984 Neuroglobin NGB 0.0013
4994 Hemoglobin-like protein HbO glbO 0.0013
4915 Cytochrome c-550 psbV 0.0013
4959 Cytochrome c-550 psbV 0.0013
5216 Cytochrome c-550 psbV 0.0013
4998 Hemoglobin-like protein yjbI yjbI 0.0013
4936 Cytochrome c2 iso-2 Not Available 0.0013
4942 Diheme cytochrome c napB napB 0.0013
4975 Cytochrome c-556 RPA3973 0.0013
4961 Hemophore HasA hasA 0.0013
4910 Cytoglobin CYGB 0.0013
4904 Cytochrome c family protein GSU1996 0.0013
5000 HemO hemO 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
4981 Iron-starvation protein PigA pigA 0.0013
4909 CooA protein cooA 0.0013
4907 Cytochrome c-L moxG 0.0013
6865 Cytochrome c-L moxG 0.0013
4976 Apocytochrome f petA 0.0013
6407 Apocytochrome f petA 0.0013
4971 Nonaheme cytochrome c hmcA 0.0013
4764 Cytochrome P450 165C4 CYP165C4 0.0013
4989 Cytochrome c551 peroxidase ccp 0.0013
5222 Cytochrome c551 peroxidase ccpA 0.0013
4935 Cytochrome c-554 cycA1 0.0013
4937 Cytochrome oxidase subunit II rcoxA 0.0013
4999 Cytochrome P450 165B3 CYP165B3 0.0013
4926 Heme-based aerotactic transducer hemAT hemAT 0.0013
4960 Putative cytochrome P450-family protein SCO7417 0.0013
4931 Cytochrome P450 167A1 CYP167A1 0.0013
4972 P450cin cinA 0.0013
4993 Hydroxylamine oxidoreductase hao1 0.0013
4922 Cytochrome c, putative SO_4144 0.0013
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0013
4952 Catalase/peroxidase katA 0.0013
4903 Methyl-accepting chemotaxis protein Tar4 0.0013
3093 Catalase HPII katE 0.0013
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
2802 Endoglucanase G celCCG 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
2077 Caspase-3 CASP3 0.0013
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
5818 Folate receptor alpha FOLR1 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
85 Growth hormone receptor GHR 0.0012
1295 Fatty acid synthase FASN 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4920 Peroxidase/catalase katG 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
345 Plasma retinol-binding protein RBP4 0.001
2119 Cytochrome b5 CYB5A 0.001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
4990 PpcA ppcA 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
4992 Cytochrome c peroxidase Not Available 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
3375 Acidic cytochrome c3 Not Available 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2617 Nitric oxide synthase oxygenase nos 0.0009
2701 Nitric oxide synthase oxygenase nos 0.0009
3291 Cytochrome c-552 cycA 0.0009
4927 Cytochrome c-552 nrfA 0.0009
4938 Cytochrome c-552 cycA 0.0009
4953 Cytochrome c-552 nrfA 0.0009
5217 Cytochrome c-552 cycM 0.0009
2132 Protein S100-B S100B 0.0009
3102 Flavohemoprotein hmp 0.0009
4969 Flavohemoprotein hmp 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
1184 Interferon beta IFNB1 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4608 Putative cytochrome P450 SCO1207 0.0007
4963 Putative cytochrome P450 SCO2884 0.0007
6254 Putative cytochrome P450 SCO6998 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
693 Hemoglobin subunit beta HBB 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
6268 Hydroxyacid oxidase 1 HAO1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2430 Chondroitinase B cslB 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6021 Adenosine kinase ADK 0.0002
2440 Endoglucanase F celCCF 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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