DT-Web: DB01393

Identification

Name

Bezafibrate

Accession Number

DB01393 (DB08380)

Type

small molecule

Description

Antilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antilipemic Agents

Molecular Weight

361.819

Groups

approved

Monoisotopic Weight

361.10808584

Pharmacology

Indication

For the treatment of primary hyperlipidaemia types IIa, IIb, III, IV and V (Fredrickson classification) corresponding to groups I, II and III of the European Atherosclerosis Society guidelines - when diet alone or improvements in lifestyle such as increased exercise or weight reduction do not lead to an adequate response. Also for the treatment of secondary hyperlipidaemias, e.g. severe hypertriglyceridemias, when sufficient improvement does not occur after correction of the underlying disorder (e.g. diabetes mellitus).

Mechanism of action

Like the other fibrates, bezafibrate is an agonist of PPARα; some studies suggest it may have some activity on PPARγ and PPARδ as well.

Absorption

Bezafibrate is almost completely absorbed after oral administration. The relative bioavailability of bezafibrate retard compared to the standard form is about 70%.

Protein binding

94-96% of bezafibrate is bound to protein in human serum.

Biotransformation

Hepatic.

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atorvastatin	Increased risk of myopathy/rhabdomyolysis
Cerivastatin	Increased risk of myopathy/rhabdomyolysis
Cholestyramine	Bile acid sequestrants like cholestyramine may decrease the absorption of fibric acid derivatives like bezafibrate. Therapy modification should be considered. If concomitant therapy is used, separate doses by at least 2 hours to minimize this interaction. Fenofibric acid labeling recommends administration one hour prior to or 4-6 hours after a bile acid sequestrant.
Conivaptan	Conivaptan may increase the serum concentration of CYP3A4 substrates like bezafibrates. Consider therapy modification. Conivaptan may increase the serum concentration of CYP3A4 substrates.
Cyclosporine	Cyclosporine may enhance the nephrotoxic effect of fibric acid derivatives like bezafibrate. Fibric acid derivatives may decrease the serum concentration of cyclosporine. Extra monitoring of renal function and cyclosporine concentrations will likely be required. Adjustment of cyclosporine dose may be necessary.
Fluvastatin	Increased risk of myopathy/rhabdomyolysis
Isocarboxazid	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like isocarboxazid.
Linezolid	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like linezolid.
Lovastatin	Increased risk of myopathy/rhabdomyolysis
Moclobemide	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like moclobemide.
Phenelzine	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like phenelzine.
Pravastatin	Increased risk of myopathy/rhabdomyolysis
Procarbazine	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like procarbazine.
Rasagiline	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) rasagiline.
Selegiline	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like selegiline.
Tranylcypromine	MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) like tranylcypromine.
Warfarin	Bezafibrate may increase the anticoagulant effect of warfarin. Monitor prothrombin time and therapeutic and adverse effects of warfarin if bezafibrate is initiated, discontinued or dose changed.

Food Interactions

Not Available

Peroxisome proliferator-activated receptor alpha
Name	Peroxisome proliferator-activated receptor alpha
Gene Name	PPARA
Pharmacological action	yes
Actions	agonist
References	Pedraza N, Solanes G, Carmona MC, Iglesias R, Vinas O, Mampel T, Vazquez M, Giralt M, Villarroya F: Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene. Diabetes. 2000 Jul;49(7):1224-30. - Pubmed Cabrero A, Alegret M, Sanchez R, Adzet T, Laguna JC, Vazquez M: Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes. Arch Biochem Biophys. 2000 Aug 15;380(2):353-9. - Pubmed Inoue I, Goto S, Matsunaga T, Nakajima T, Awata T, Hokari S, Komoda T, Katayama S: The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001 Jan;50(1):3-11. - Pubmed Guan Y, Breyer MD: Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int. 2001 Jul;60(1):14-30. - Pubmed Bonilla S, Redonnet A, Noel-Suberville C, Groubet R, Pallet V, Higueret P: Effect of a pharmacological activation of PPAR on the expression of RAR and TR in rat liver. J Physiol Biochem. 2001 Mar;57(1):1-8. - Pubmed Goldenberg I, Benderly M, Goldbourt U: Update on the use of fibrates: focus on bezafibrate. Vasc Health Risk Manag. 2008;4(1):131-41. - Pubmed Fruchart JC, Duriez P: Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. Drugs Today (Barc). 2006 Jan;42(1):39-64. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5555
Peroxisome proliferator-activated receptor delta
Name	Peroxisome proliferator-activated receptor delta
Gene Name	PPARD
Pharmacological action	yes
Actions	agonist
References	Tenenbaum A, Motro M, Fisman EZ: Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Cardiovasc Diabetol. 2005 Sep 16;4:14. - Pubmed
DTHybrid score	0.9662
Peroxisome proliferator-activated receptor gamma
Name	Peroxisome proliferator-activated receptor gamma
Gene Name	PPARG
Pharmacological action	yes
Actions	agonist
References	Tenenbaum A, Motro M, Fisman EZ: Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Cardiovasc Diabetol. 2005 Sep 16;4:14. - Pubmed
DTHybrid score	1.0859

Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2388
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2876
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4447

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. - Pubmed
DTHybrid score	0.2482

Id	Partner name	Gene Name	Score
6228	Nuclear receptor coactivator 1	NCOA1	0.2316
4757	Cytochrome P450 2C9	CYP2C9	0.2279
4200	Cytochrome P450 1A2	CYP1A2	0.1782
1588	Multidrug resistance protein 1	ABCB1	0.1609
4119	Cytochrome P450 2D6	CYP2D6	0.1578
6016	Cytochrome P450 2C19	CYP2C19	0.1576
4118	Cytochrome P450 3A5	CYP3A5	0.1308
5841	Insulin-like growth factor IB	IGF1	0.1126
6030	Cytochrome P450 2B6	CYP2B6	0.1001
6013	Cytochrome P450 2E1	CYP2E1	0.0914
6107	Cytochrome P450 3A7	CYP3A7	0.0863
20	Prostaglandin G/H synthase 1	PTGS1	0.0845
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0832
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0766
587	Serum albumin	ALB	0.0749
5718	Cytochrome P450 2A6	CYP2A6	0.0695
768	FK506-binding protein 1A	FKBP1A	0.0682
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0635
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0627
290	Prostaglandin G/H synthase 2	PTGS2	0.0539
1729	Solute carrier family 22 member 6	SLC22A6	0.0531
1541	Metalloproteinase	mmp20	0.0517
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0441
122	P2Y purinoceptor 12	P2RY12	0.0414
1898	Cytochrome P450 1B1	CYP1B1	0.0403
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0386
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0369
862	Multidrug resistance-associated protein 1	ABCC1	0.0366
468	Cytochrome P450 4A11	CYP4A11	0.0365
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0356
6142	Solute carrier family 22 member 8	SLC22A8	0.0336
527	Prostacyclin receptor	PTGIR	0.0331
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0311
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.031
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0303
776	Bile salt export pump	ABCB11	0.0303
6106	Cytochrome P450 2C18	CYP2C18	0.0292
459	Retinoic acid receptor RXR-alpha	RXRA	0.0291
6241	Nuclear receptor coactivator 2	NCOA2	0.028
3811	Cytochrome P450 19A1	CYP19A1	0.0271
2164	Multidrug resistance-associated protein 4	ABCC4	0.0267
871	Glucocorticoid receptor	NR3C1	0.0265
275	Arachidonate 5-lipoxygenase	ALOX5	0.0261
6145	Solute carrier family 22 member 1	SLC22A1	0.0261
136	Estrogen receptor	ESR1	0.026
3932	Glutathione S-transferase A2	GSTA2	0.0256
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0248
70	Type-1 angiotensin II receptor	AGTR1	0.0239
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0231
6043	Putative G-protein coupled receptor 44	GPR44	0.0231
492	Histamine H1 receptor	HRH1	0.0229
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0224
759	Free fatty acid receptor 1	FFAR1	0.0216
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0215
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0202
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.02
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.02
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0199
1714	Mitogen-activated protein kinase 3	MAPK3	0.0197
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0196
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0191
1053	BC269730_2	FADS1	0.0186
1395	Sodium/calcium exchanger 1	SLC8A1	0.0186
6144	Solute carrier family 22 member 2	SLC22A2	0.0181
1024	Solute carrier family 22 member 11	SLC22A11	0.018
731	HIV-1 protease	HIV-1 protease	0.0179
3312	Fatty acid-binding protein, brain	FABP7	0.0175
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0172
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.017
6141	Sodium/bile acid cotransporter	SLC10A1	0.017
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0168
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0167
118	Organic cation/carnitine transporter 2	SLC22A5	0.0165
6143	Solute carrier family 22 member 7	SLC22A7	0.0161
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0155
833	Organic cation/carnitine transporter 1	SLC22A4	0.0151
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0147
824	Sodium-dependent serotonin transporter	SLC6A4	0.0146
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0141
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0137
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0136
318	Alpha-2A adrenergic receptor	ADRA2A	0.0132
822	Aldose reductase	AKR1B1	0.0131
502	5-hydroxytryptamine 2A receptor	HTR2A	0.013
1757	Myeloperoxidase	MPO	0.013
847	Mu-type opioid receptor	OPRM1	0.0127
6147	Solute carrier family 22 member 3	SLC22A3	0.0127
831	D(2) dopamine receptor	DRD2	0.0126
556	Alpha-1A adrenergic receptor	ADRA1A	0.0125
703	NADPH azoreductase	azr	0.0122
766	Beta-2 adrenergic receptor	ADRB2	0.012
467	Delta-type opioid receptor	OPRD1	0.0118
3587	Gastrotropin	FABP6	0.0118
6148	Multidrug resistance-associated protein 7	ABCC10	0.0117
758	Thyroid hormone receptor alpha	THRA	0.0116
48	Pyridoxal kinase	PDXK	0.0116
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0115
777	Tumor necrosis factor	TNF	0.0115
4604	Liver carboxylesterase 1	CES1	0.0115
6014	Cytochrome P450 2A13	CYP2A13	0.0114
5880	Thrombopoietin receptor	MPL	0.0114
33	Cystine/glutamate transporter	SLC7A11	0.0113
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0112
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0111
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0111
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.011
6031	Cytochrome P450 3A43	CYP3A43	0.0109
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0109
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0109
193	Beta-1 adrenergic receptor	ADRB1	0.0107
696	Kappa-type opioid receptor	OPRK1	0.0106
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0105
346	Thyroid hormone receptor beta-1	THRB	0.0103
29	Tubulin beta-1 chain	TUBB1	0.0102
260	Cytochrome P450 51	ERG11	0.0101
761	Cytochrome P450 51	ERG11	0.0101
3163	Cytochrome P450 51	cyp51	0.0101
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0101
373	Transthyretin	TTR	0.01
6182	Cytochrome P450 2J2	CYP2J2	0.0099
2499	Tubulin beta-2C chain	TUBB2C	0.0098
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0096
146	Androgen receptor	AR	0.0095
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0094
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0094
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0094
2449	Tubulin alpha-3 chain	TUBA1A	0.0094
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0094
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0094
26	Vascular endothelial growth factor receptor 3	FLT4	0.0093
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0092
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0091
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0091
738	Monocarboxylate transporter 1	SLC16A1	0.0091
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0091
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.009
613	Atrial natriuretic peptide receptor A	NPR1	0.009
614	Progesterone receptor	PGR	0.009
844	Epidermal growth factor receptor	EGFR	0.0089
32	Vascular endothelial growth factor receptor 1	FLT1	0.0089
407	Vascular endothelial growth factor receptor 2	KDR	0.0088
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0088
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0087
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0086
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0085
6136	Multidrug resistance-associated protein 5	ABCC5	0.0085
23	D(1A) dopamine receptor	DRD1	0.0085
632	Alpha-1B adrenergic receptor	ADRA1B	0.0085
504	Mast/stem cell growth factor receptor	KIT	0.0084
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0084
3941	Amine oxidase [flavin-containing] A	MAOA	0.0083
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
594	Thyroxine-binding globulin	SERPINA7	0.0083
465	Calmodulin	CALM1	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.008
725	5-hydroxytryptamine 1D receptor	HTR1D	0.008
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0078
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0078
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0078
1517	Beta-3 adrenergic receptor	ADRB3	0.0076
952	Dipeptidyl peptidase 4	DPP4	0.0074
3809	Estrogen-related receptor gamma	ESRRG	0.0072
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0072
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.007
2539	Tubulin alpha-1 chain	TUBA4A	0.007
6085	Fatty acid-binding protein, intestinal	FABP2	0.007
6220	Aryl hydrocarbon receptor	AHR	0.007
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0069
869	Estrogen receptor beta	ESR2	0.0069
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0069
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0069
811	Translocator protein	TSPO	0.0068
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0068
3947	Xanthine dehydrogenase/oxidase	XDH	0.0068
6102	Arylamine N-acetyltransferase 2	NAT2	0.0068
380	Cytochrome P450 17A1	CYP17A1	0.0067
1010	Cytochrome P450 51A1	CYP51A1	0.0067
756	Sex hormone-binding globulin	SHBG	0.0066
817	DNA topoisomerase 2-alpha	TOP2A	0.0066
6167	Organic solute transporter subunit beta	OSTB	0.0066
6166	Organic solute transporter subunit alpha	OSTA	0.0066
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0066
789	Alpha-1D adrenergic receptor	ADRA1D	0.0066
638	D(3) dopamine receptor	DRD3	0.0066
6020	Aldehyde oxidase	AOX1	0.0065
267	Plasminogen activator inhibitor 1	SERPINE1	0.0065
6137	Multidrug resistance-associated protein 6	ABCC6	0.0064
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0064
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0064
4203	Histamine N-methyltransferase	HNMT	0.0064
629	Alpha-2B adrenergic receptor	ADRA2B	0.0063
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0062
3923	Cholinesterase	BCHE	0.0062
6221	Steroid hormone receptor ERR1	ESRRA	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0061
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0061
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0061
68	Cannabinoid receptor 1	CNR1	0.006
378	Alpha-2C adrenergic receptor	ADRA2C	0.006
713	Sodium-dependent dopamine transporter	SLC6A3	0.006
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0059
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
818	50S ribosomal protein L10	rplJ	0.0058
790	DNA polymerase subunit alpha B	POLA2	0.0058
814	Ryanodine receptor 1	RYR1	0.0058
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0057
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0057
856	Vitamin D3 receptor	VDR	0.0056
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0056
737	Mineralocorticoid receptor	NR3C2	0.0056
4122	Histone deacetylase 2	HDAC2	0.0055
1650	Heme carrier protein 1	SLC46A1	0.0055
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0055
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0055
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0054
4228	Keratin, type II cytoskeletal 7	KRT7	0.0054
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0054
199	Monocarboxylate transporter 8	SLC16A2	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
820	Glycine receptor subunit alpha-2	GLRA2	0.0053
365	Dihydrofolate reductase	DHFR	0.0053
2381	Dihydrofolate reductase	DFR1	0.0053
2833	Dihydrofolate reductase	Not Available	0.0053
2931	Dihydrofolate reductase	folA	0.0053
3544	Dihydrofolate reductase	folA	0.0053
3682	Dihydrofolate reductase	folA	0.0053
6642	Dihydrofolate reductase	folA	0.0053
6756	Dihydrofolate reductase	dfrA	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0052
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0052
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0051
4120	NADPH--cytochrome P450 reductase	POR	0.005
3856	Fibroblast growth factor receptor 3	FGFR3	0.005
1050	Bile salt sulfotransferase	SULT2A1	0.005
16	Adenosine A1 receptor	ADORA1	0.005
1629	Transcription factor AP-1	JUN	0.0049
4311	tRNA	TRDMT1	0.0049
4325	tRNA	trmD	0.0049
4328	tRNA	trmD	0.0049
1178	Adenosine A2a receptor	ADORA2A	0.0049
88	Retinoic acid receptor RXR-beta	RXRB	0.0048
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0048
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0047
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0047
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
295	Carbonic anhydrase 1	CA1	0.0047
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0046
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0046
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0046
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0046
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0046
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0046
284	DNA-directed RNA polymerase beta chain	rpoB	0.0046
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0046
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0045
581	Cytochrome P450 2R1	CYP2R1	0.0045
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0045
161	Tubulin beta chain	TUBB	0.0044
312	Tubulin beta chain	TUB2	0.0044
563	Thyroid peroxidase	TPO	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0043
891	Dihydropteroate synthase	folP	0.0043
5359	Dihydropteroate synthase	folP	0.0043
7175	Dihydropteroate synthase	sulI	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0043
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0042
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0042
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0042
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0042
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0041
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0041
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
592	Carbonic anhydrase 4	CA4	0.004
84	Nuclear receptor 0B1	NR0B1	0.004
6146	High affinity copper uptake protein 1	SLC31A1	0.004
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.004
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.004
6766	O-GlcNAcase BT_4395	BT_4395	0.004
1192	Sulfotransferase 1A1	SULT1A1	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0039
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1525	Heparin-binding growth factor 2	FGF2	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1630	Integrin beta-2	ITGB2	0.0038
823	Fibroblast growth factor receptor 2	FGFR2	0.0038
162	Retinoic acid receptor gamma-1	RARG	0.0038
432	D(4) dopamine receptor	DRD4	0.0038
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0038
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0037
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0037
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0037
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0037
1760	Aminopeptidase N	ANPEP	0.0037
6843	Aminopeptidase N	pepN	0.0037
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0037
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0037
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0037
716	5-hydroxytryptamine 7 receptor	HTR7	0.0037
3939	Amine oxidase [flavin-containing] B	MAOB	0.0037
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0037
24	Thymidylate synthase	TMP1	0.0036
359	Thymidylate synthase	TYMS	0.0036
2626	Thymidylate synthase	thyA	0.0036
2729	Thymidylate synthase	thyA	0.0036
5352	Thymidylate synthase	THYA	0.0036
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0036
273	Apoptosis regulator Bcl-2	BCL2	0.0036
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0036
117	Sterol O-acyltransferase 1	SOAT1	0.0036
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0035
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0035
751	Potassium channel subfamily K member 6	KCNK6	0.0035
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
4116	Dihydropteroate synthetase	Not Available	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
477	DNA topoisomerase 4 subunit A	parC	0.0035
886	DNA topoisomerase 4 subunit A	parC	0.0035
6226	DNA topoisomerase 4 subunit A	parC	0.0035
2021	Thrombomodulin	THBD	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0035
404	DNA gyrase subunit A	gyrA	0.0035
6224	DNA gyrase subunit A	gyrA	0.0035
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0034
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0034
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
569	Retinal dehydrogenase 2	ALDH1A2	0.0034
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0033
474	Acetylcholinesterase	ACHE	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0033
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0033
106	Cannabinoid receptor 2	CNR2	0.0033
1992	Vitamin D-binding protein	GC	0.0033
172	Potassium channel subfamily K member 1	KCNK1	0.0032
469	Annexin A1	ANXA1	0.0032
611	Retinal dehydrogenase 1	ALDH1A1	0.0032
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0031
2236	Casein kinase II subunit alpha	CSNK2A1	0.0031
1353	DNA topoisomerase 1	TOP1	0.0031
3552	DNA topoisomerase 1	topA	0.0031
6044	Serum paraoxonase/lactonase 3	PON3	0.0031
976	Platelet glycoprotein IX	GP9	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1648	Elastin	ELN	0.0031
427	Substance-P receptor	TACR1	0.0031
5934	Cytochrome P450 26A1	CYP26A1	0.0031
6151	Monocarboxylate transporter 10	SLC16A10	0.0031
921	Glutamate receptor 2	GRIA2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
634	Squalene monooxygenase	SQLE	0.003
7196	Squalene monooxygenase	ERG1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
357	Carbonic anhydrase 2	CA2	0.003
4103	Proteasome subunit beta type 2	PSMB2	0.003
4102	Proteasome subunit beta type 5	PSMB5	0.003
4101	Proteasome subunit beta type 1	PSMB1	0.003
94	5-hydroxytryptamine 4 receptor	HTR4	0.003
208	DNA-directed RNA polymerase beta' chain	rpoC	0.003
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0029
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0029
6138	Multidrug resistance protein 3	ABCB4	0.0029
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0029
572	Integrin alpha-L	ITGAL	0.0029
1569	G1/S-specific cyclin-D1	CCND1	0.0029
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0029
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0029
780	Retinoic acid receptor RXR-gamma	RXRG	0.0029
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0028
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0028
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0028
239	Coagulation factor X	F10	0.0028
6168	Solute carrier family 22 member 16	SLC22A16	0.0028
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
760	Fibroblast growth factor 1	FGF1	0.0026
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0026
571	Melatonin receptor type 1A	MTNR1A	0.0026
719	Retinoic acid receptor responder protein 1	RARRES1	0.0026
770	Retinoic acid-induced protein 3	GPRC5A	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
904	Glutathione S-transferase P	GSTP1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
268	Adenosine A2b receptor	ADORA2B	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
1792	Tissue-type plasminogen activator	PLAT	0.0025
551	Carnitine O-acetyltransferase	CRAT	0.0025
4192	DNA topoisomerase 2-beta	TOP2B	0.0025
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0025
936	Ephrin type-A receptor 2	EPHA2	0.0025
6103	Arylamine N-acetyltransferase 1	NAT1	0.0025
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0024
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
482	Glycine receptor subunit alpha-1	GLRA1	0.0024
229	Retinoic acid receptor beta	RARB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6149	Solute carrier family 22 member 10	SLC22A10	0.0023
730	Retinoic acid receptor alpha	RARA	0.0023
518	Peroxidase/catalase T	katG	0.0023
5787	Angiopoietin-1 receptor	TEK	0.0023
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0023
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0023
3810	Catechol O-methyltransferase	COMT	0.0023
1852	Microtubule-associated protein 2	MAP2	0.0023
6126	Carbonic anhydrase 7	CA7	0.0023
6042	Prostaglandin reductase 2	PTGR2	0.0023
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0022
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0022
3937	Fatty-acid amide hydrolase	FAAH	0.0022
124	Histamine H2 receptor	HRH2	0.0022
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0022
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0022
6131	Carbonic anhydrase 14	CA14	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0022
183	Vascular endothelial growth factor A	VEGFA	0.0022
517	Alcohol dehydrogenase 1C	ADH1C	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0021
1275	Estrogen sulfotransferase	SULT1E1	0.0021
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0021
165	FL cytokine receptor	FLT3	0.0021
6174	50S ribosomal protein L32	rpmF	0.0021
1656	CYP2B protein	CYP2B	0.0021
558	Solute carrier family 12 member 1	SLC12A1	0.0021
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0021
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0021
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0021
163	D(1B) dopamine receptor	DRD5	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
1374	Natriuretic peptides B	NPPB	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
1827	Gap junction alpha-1 protein	GJA1	0.0021
1908	Vascular cell adhesion protein 1	VCAM1	0.0021
564	Cellular retinoic acid-binding protein 1	CRABP1	0.002
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
908	Glutathione S-transferase theta-1	GSTT1	0.002
6122	Carbonic anhydrase 3	CA3	0.002
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.002
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.002
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.002
528	5-hydroxytryptamine 1E receptor	HTR1E	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0019
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0019
251	Alcohol dehydrogenase 1A	ADH1A	0.0019
3830	Calreticulin	CALR	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
2808	Chloramphenicol acetyltransferase 3	cat3	0.0018
1313	Lactoylglutathione lyase	GLO1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
1262	Corticotropin-lipotropin	POMC	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
683	Potassium transporter	GK0582	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0018
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0018
896	Glutathione S-transferase Mu 1	GSTM1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
6034	Hydroxyindole O-methyltransferase	ASMT	0.0017
6035	Nuclear receptor ROR-beta	RORB	0.0017
6036	Eosinophil peroxidase	EPX	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0017
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0017
164	Histamine H4 receptor	HRH4	0.0017
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
400	Coagulation factor IX	F9	0.0017
5461	Coagulation factor IX	F9	0.0017
3957	Adenosine deaminase	ADA	0.0017
54	Prothrombin	F2	0.0017
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
1618	High affinity nerve growth factor receptor	NTRK1	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0016
484	Tyrosine-protein kinase ABL2	ABL2	0.0016
444	Alcohol dehydrogenase 1B	ADH1B	0.0016
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0016
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0016
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0016
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3233	Bile acid receptor	NR1H4	0.0015
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0015
604	Vitamin K-dependent protein Z	PROZ	0.0015
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
765	Indoleamine 2,3-dioxygenase	IDO1	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
6033	High affinity interleukin-8 receptor A	CXCR1	0.0015
319	Opioid receptor, sigma 1	OPRS1	0.0015
7	Nitric oxide synthase, inducible	NOS2	0.0014
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
5923	Microtubule-associated protein tau	MAPT	0.0014
5924	Microtubule-associated protein 4	MAP4	0.0014
422	Vitamin K-dependent protein C	PROC	0.0014
1245	Vitamin K-dependent protein S	PROS1	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0014
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0013
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0013
2216	Fibroblast growth factor receptor 4	FGFR4	0.0013
4217	Telomerase reverse transcriptase	TERT	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
3007	Carbonic anhydrase 12	CA12	0.0013
4205	Carbonic anhydrase 9	CA9	0.0013
6163	Copper-transporting ATPase 2	ATP7B	0.0013
6165	Copper-transporting ATPase 1	ATP7A	0.0013
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
174	Sigma 1-type opioid receptor	SIGMAR1	0.0012
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0012
293	Gamma-glutamyl hydrolase	GGH	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
1295	Fatty acid synthase	FASN	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
489	Monocarboxylate transporter 2	SLC16A7	0.0012
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0011
798	Osteocalcin	BGLAP	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
2408	Tyrosine-protein kinase SYK	SYK	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
5798	Mitogen-activated protein kinase 11	MAPK11	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2320	Thymidine kinase, cytosolic	TK1	0.001
6501	Fatty acid-binding protein, liver	FABP1	0.001
369	Coagulation factor VII	F7	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
345	Plasma retinol-binding protein	RBP4	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
4226	Uridine phosphorylase 2	UPP2	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
2207	Rhodopsin	RHO	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6218	Pannexin-1	PANX1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
6677	Myelin P2 protein	PMP2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
4225	Uridine phosphorylase 1	UPP1	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
6500	Phospholipase A2	PLA2G1B	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
413	Amidophosphoribosyltransferase	PPAT	0.0008
2515	Amidophosphoribosyltransferase	purF	0.0008
3714	Amidophosphoribosyltransferase	purF	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
6432	Transporter	snf	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2298	Cytochrome P450-cam	camC	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
125	DNA polymerase beta	POLB	0.0007
3639	Thymidine phosphorylase	deoA	0.0007
3936	Thymidine phosphorylase	TYMP	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1341	Histamine H3 receptor	HRH3	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
291	Nitric-oxide synthase, endothelial	NOS3	0.0004
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4943	Cytochrome c6	petJ	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4961	Hemophore HasA	hasA	0.0003
4909	CooA protein	cooA	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4984	Neuroglobin	NGB	0.0003
5000	HemO	hemO	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4910	Cytoglobin	CYGB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4972	P450cin	cinA	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0002
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
4920	Peroxidase/catalase	katG	0.0002
4948	Cytochrome c-553	Not Available	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
3221	Cytochrome c4	cc4	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01393 - Bezafibrate

Targets

Enzymes

Transporters

Predictions