DT-Web: DB00175

Identification

Name

Pravastatin

Accession Number

DB00175 (APRD00328)

Type

small molecule

Description

Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. It was derived from microbial transformation of mevastatin, the first statin discovered. It is a ring-opened dihydroxyacid with a 6'-hydroxyl group that does not require in vivo activation. Pravastatin is one of the lower potency statins; however, its increased hydrophilicity is thought to confer advantages such as minimal penetration through lipophilic membranes of peripheral cells, increased selectivity for hepatic tissues, and a reduction in side effects compared with lovastatin and simvastatin.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

424.5277

Groups

approved

Monoisotopic Weight

424.246103506

Pharmacology

Indication

For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease.

Mechanism of action

Pravastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Unlike its parent compound, mevastatin, and statins such as lovastatin and simvastatin, pravastatin does not need to be activated in vivo. Its hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with a much greater affinity than its natural substrate. The bicyclic portion of pravastatin binds to the coenzyme A portion of the active site. Pravastatin sodium produces its lipid-lowering effect in two ways. First, as a consequence of its reversible inhibition of HMG-CoA reductase activity, it effects modest reductions in intracellular pools of cholesterol. This results in an increase in the number of LDL-receptors on cell surfaces and enhanced receptor-mediated catabolism and clearance of circulating LDL. Second, pravastatin inhibits LDL production by inhibiting hepatic synthesis of VLDL, the LDL precursor.

Absorption

Pravastatin is rapidly absorbed with peak plasma levels of the parent compound achieved 1 to 1.5 hours after administration. The average oral absorption of pravastatin is 34% and absolute bioavailability is 17%. These values however, are variable. Food decreases the systemic bioavailability but the lipid-lowering effect is not impacted. When 20 mg of pravastatin is given orally, the pharmacokinetic parameters are as follows: Cmax = 23.3-26.3 ng/mL; AUC = 54.7 to 62.2 ngohr/mL.

Protein binding

50% bound to human plasma proteins.

Biotransformation

Hepatic, there is a small amount of metabolism by P450 enzymes, but this effect is so minimal that inhibitory pharmacokinetic drug interactions have no real effect on its overall activity and elimination. An in vitro study which found moderate affinity for P450 2C9 (major), 2D6 and 3A4. Furthermore, the major degradation product is the 3?-hydroxy isomeric metabolite, which has one-tenth to one-fortieth the HMG-CoA reductase inhibitory activity of the parent compound.

Route of elimination

Approximately 20% of a radiolabeled oral dose is excreted in urine and 70% in the feces. After intravenous administration, 47% of total body clearance was via renal excretion, while 53% was eliminated by non-renal routes.

Toxicity

Side effects include diarrhea, nausea, constipation, gas abdominal pain, myopathy, myositis, rhabdomyolysis, and hepatotoxicity. LD₅₀= 12,000 mg/kg (orally in rat)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Bezafibrate	Increased risk of myopathy/rhabdomyolysis
Boceprevir	Boceprevir increases pravastatin AUC by 60% with boceprevir. Concomitant therapy should be closely monitored.
Colchicine	Increased risk of rhabdomyolysis with this combination
Colesevelam	Bile Acid Sequestrants may decrease the serum concentration of Pravastatin. Administer pravastatin at least 1 hour before or 4 hours after administration of bile-acid resins (eg, cholestyramine, colestipol, colesevelam) to minimize the risk for any significant interaction.
Cyclosporine	Possible myopathy and rhabdomyolysis
Fenofibrate	Increased risk of myopathy/rhabdomyolysis
Gemfibrozil	Increased risk of myopathy/rhabdomyolysis
Repaglinide	Substrates of organic anion transporters may increase levels of repaglinide. Monitor concomitant therapy closely.
Tipranavir	Tipranavir may increase the plasma concentration of Pravastatin. Consider alternate therapy.

Food Interactions

Avoid drastic changes in dietary habit.
Take without regard to meals.
Avoid alcohol.

3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name	HMGCR
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.4286

Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5443
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.653
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5651
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9065
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4956

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate,inhibitor
References	Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA: Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46. Epub 2004 Dec 22. - Pubmed Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. - Pubmed Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B15, SLCO1B115 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. - Pubmed Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. - Pubmed
DTHybrid score	0.5278
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate,inhibitor
References	Mougey EB, Feng H, Castro M, Irvin CG, Lima JJ: Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenet Genomics. 2009 Feb;19(2):129-38. - Pubmed Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. - Pubmed Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. - Pubmed
DTHybrid score	0.3975
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA: Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46. Epub 2004 Dec 22. - Pubmed Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score	0.7584
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. - Pubmed
DTHybrid score	0.4578
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther. 2002 Mar;300(3):746-53. - Pubmed
DTHybrid score	0.6018
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate,inhibitor
References	Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther. 2002 Mar;300(3):746-53. - Pubmed
DTHybrid score	0.5284
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA: Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46. Epub 2004 Dec 22. - Pubmed Yamazaki M, Akiyama S, Ni'inuma K, Nishigaki R, Sugiyama Y: Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter. Drug Metab Dispos. 1997 Oct;25(10):1123-9. - Pubmed Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y: Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). J Biol Chem. 2002 Feb 22;277(8):6497-503. Epub 2001 Dec 17. - Pubmed Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score	0.431
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
DTHybrid score	0.3696
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate,inhibitor
References	Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y: ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. Epub 2003 Apr 7. - Pubmed Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score	0.436
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. - Pubmed
DTHybrid score	0.337
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	Not Available
References	Tamai I, Takanaga H, Maeda H, Ogihara T, Yoneda M, Tsuji A: Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm Res. 1995 Nov;12(11):1727-32. - Pubmed
DTHybrid score	0.3177
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate
References	Morisawa Y, Takikawa H: Effect of bile acids on the biliary excretion of pravastatin in rats. Hepatol Res. 2009 Jun;39(6):595-600. doi: 10.1111/j.1872-034X.2009.00493.x. Epub 2009 Feb 24. - Pubmed
DTHybrid score	0.2871
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	http://www.pharmgkb.org/pathway/PA145011110 -
DTHybrid score	0.3738

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.4365
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.4286
4200	Cytochrome P450 1A2	CYP1A2	0.347
6107	Cytochrome P450 3A7	CYP3A7	0.3193
587	Serum albumin	ALB	0.2976
862	Multidrug resistance-associated protein 1	ABCC1	0.2496
6030	Cytochrome P450 2B6	CYP2B6	0.2409
2164	Multidrug resistance-associated protein 4	ABCC4	0.1926
20	Prostaglandin G/H synthase 1	PTGS1	0.1843
6024	Cytochrome P450 1A1	CYP1A1	0.1784
6013	Cytochrome P450 2E1	CYP2E1	0.1746
6145	Solute carrier family 22 member 1	SLC22A1	0.1598
6141	Sodium/bile acid cotransporter	SLC10A1	0.1519
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1387
118	Organic cation/carnitine transporter 2	SLC22A5	0.1384
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1361
290	Prostaglandin G/H synthase 2	PTGS2	0.1327
489	Monocarboxylate transporter 2	SLC16A7	0.1308
5718	Cytochrome P450 2A6	CYP2A6	0.1273
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1244
6144	Solute carrier family 22 member 2	SLC22A2	0.1203
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.1188
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1121
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1041
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0995
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0992
500	Monocarboxylate transporter 4	SLC16A3	0.0975
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.097
1898	Cytochrome P450 1B1	CYP1B1	0.0957
6148	Multidrug resistance-associated protein 7	ABCC10	0.0878
492	Histamine H1 receptor	HRH1	0.0857
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0848
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.081
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0807
4604	Liver carboxylesterase 1	CES1	0.0801
6136	Multidrug resistance-associated protein 5	ABCC5	0.0776
6106	Cytochrome P450 2C18	CYP2C18	0.077
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0769
136	Estrogen receptor	ESR1	0.0754
833	Organic cation/carnitine transporter 1	SLC22A4	0.07
70	Type-1 angiotensin II receptor	AGTR1	0.0694
3811	Cytochrome P450 19A1	CYP19A1	0.0674
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0665
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0661
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.066
3587	Gastrotropin	FABP6	0.0626
824	Sodium-dependent serotonin transporter	SLC6A4	0.0617
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0614
33	Cystine/glutamate transporter	SLC7A11	0.0602
6167	Organic solute transporter subunit beta	OSTB	0.057
6166	Organic solute transporter subunit alpha	OSTA	0.057
6147	Solute carrier family 22 member 3	SLC22A3	0.0567
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0558
556	Alpha-1A adrenergic receptor	ADRA1A	0.0539
6137	Multidrug resistance-associated protein 6	ABCC6	0.0526
731	HIV-1 protease	HIV-1 protease	0.0518
871	Glucocorticoid receptor	NR3C1	0.0517
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0516
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0512
831	D(2) dopamine receptor	DRD2	0.0491
6149	Solute carrier family 22 member 10	SLC22A10	0.049
6031	Cytochrome P450 3A43	CYP3A43	0.0489
817	DNA topoisomerase 2-alpha	TOP2A	0.0485
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0482
502	5-hydroxytryptamine 2A receptor	HTR2A	0.048
320	5-hydroxytryptamine 1A receptor	HTR1A	0.048
22	30S ribosomal protein S4	rpsD	0.047
6714	30S ribosomal protein S4	rpsD	0.047
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0469
140	30S ribosomal protein S9	rpsI	0.0466
6719	30S ribosomal protein S9	rpsI	0.0466
6725	30S ribosomal protein S9	rpsI	0.0466
338	DNA polymerase	UL30	0.0446
379	DNA polymerase	UL54	0.0446
697	DNA polymerase	ORF28	0.0446
2482	DNA polymerase	43	0.0446
4104	DNA polymerase	BALF5	0.0446
468	Cytochrome P450 4A11	CYP4A11	0.0434
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0432
847	Mu-type opioid receptor	OPRM1	0.0427
4589	3-hydroxy-3-methylglutaryl CoA synthase	mvaS	0.0417
29	Tubulin beta-1 chain	TUBB1	0.0408
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0401
275	Arachidonate 5-lipoxygenase	ALOX5	0.0388
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0384
318	Alpha-2A adrenergic receptor	ADRA2A	0.0369
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0368
766	Beta-2 adrenergic receptor	ADRB2	0.0368
3947	Xanthine dehydrogenase/oxidase	XDH	0.0364
467	Delta-type opioid receptor	OPRD1	0.0359
887	DNA gyrase subunit B	gyrB	0.0357
4150	DNA gyrase subunit B	gyrB	0.0357
6225	DNA gyrase subunit B	gyrB	0.0357
373	Transthyretin	TTR	0.0343
696	Kappa-type opioid receptor	OPRK1	0.0335
6020	Aldehyde oxidase	AOX1	0.0334
504	Mast/stem cell growth factor receptor	KIT	0.0332
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0332
756	Sex hormone-binding globulin	SHBG	0.0332
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0331
6599	HTH-type transcriptional regulator ttgR	ttgR	0.033
404	DNA gyrase subunit A	gyrA	0.0328
6224	DNA gyrase subunit A	gyrA	0.0328
193	Beta-1 adrenergic receptor	ADRB1	0.0325
758	Thyroid hormone receptor alpha	THRA	0.0322
146	Androgen receptor	AR	0.0322
632	Alpha-1B adrenergic receptor	ADRA1B	0.0321
633	Penicillin-binding proteins 1A/1B	pbpA	0.032
3941	Amine oxidase [flavin-containing] A	MAOA	0.032
672	Prostaglandin F2-alpha receptor	PTGFR	0.0319
844	Epidermal growth factor receptor	EGFR	0.0315
713	Sodium-dependent dopamine transporter	SLC6A3	0.0315
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0314
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0312
594	Thyroxine-binding globulin	SERPINA7	0.0306
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0304
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0302
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0301
869	Estrogen receptor beta	ESR2	0.0298
273	Apoptosis regulator Bcl-2	BCL2	0.0297
23	D(1A) dopamine receptor	DRD1	0.0295
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0288
346	Thyroid hormone receptor beta-1	THRB	0.0288
244	Angiotensin-converting enzyme	ACE	0.0288
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0286
24	Thymidylate synthase	TMP1	0.0283
359	Thymidylate synthase	TYMS	0.0283
2626	Thymidylate synthase	thyA	0.0283
2729	Thymidylate synthase	thyA	0.0283
5352	Thymidylate synthase	THYA	0.0283
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0282
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0282
6182	Cytochrome P450 2J2	CYP2J2	0.0278
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0277
2539	Tubulin alpha-1 chain	TUBA4A	0.0277
6151	Monocarboxylate transporter 10	SLC16A10	0.0275
645	Penicillin-binding protein 1A	mrcA	0.0274
5805	Penicillin-binding protein 1A	ponA	0.0274
6185	Penicillin-binding protein 1A	mrcA	0.0274
6799	Penicillin-binding protein 1A	pbpA	0.0274
558	Solute carrier family 12 member 1	SLC12A1	0.0273
3923	Cholinesterase	BCHE	0.0272
614	Progesterone receptor	PGR	0.027
5353	Glutamate decarboxylase alpha	gadA	0.027
737	Mineralocorticoid receptor	NR3C2	0.0269
407	Vascular endothelial growth factor receptor 2	KDR	0.0268
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0266
6220	Aryl hydrocarbon receptor	AHR	0.0266
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0265
380	Cytochrome P450 17A1	CYP17A1	0.0265
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0264
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0261
124	Histamine H2 receptor	HRH2	0.026
952	Dipeptidyl peptidase 4	DPP4	0.0259
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0258
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0258
6085	Fatty acid-binding protein, intestinal	FABP2	0.0257
260	Cytochrome P450 51	ERG11	0.0256
761	Cytochrome P450 51	ERG11	0.0256
3163	Cytochrome P450 51	cyp51	0.0256
477	DNA topoisomerase 4 subunit A	parC	0.0255
886	DNA topoisomerase 4 subunit A	parC	0.0255
6226	DNA topoisomerase 4 subunit A	parC	0.0255
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0253
26	Vascular endothelial growth factor receptor 3	FLT4	0.0253
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0252
1852	Microtubule-associated protein 2	MAP2	0.0251
527	Prostacyclin receptor	PTGIR	0.0249
4120	NADPH--cytochrome P450 reductase	POR	0.0249
438	Taste receptor type 1 member 2	TAS1R2	0.0248
2929	(S)-2-haloacid dehalogenase	dhlB	0.0248
2995	(S)-2-haloacid dehalogenase	Not Available	0.0248
904	Glutathione S-transferase P	GSTP1	0.0248
543	Penicillin-binding protein 1B	mrcB	0.0246
6186	Penicillin-binding protein 1B	ponB	0.0246
6822	Penicillin-binding protein 1b	pbp1b	0.0246
6844	Penicillin-binding protein 1b	pbp1b	0.0246
5923	Microtubule-associated protein tau	MAPT	0.0244
5924	Microtubule-associated protein 4	MAP4	0.0244
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0244
32	Vascular endothelial growth factor receptor 1	FLT1	0.0242
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0242
4122	Histone deacetylase 2	HDAC2	0.0241
161	Tubulin beta chain	TUBB	0.024
312	Tubulin beta chain	TUB2	0.024
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.024
5650	NimA-related protein	DR_0842	0.024
357	Carbonic anhydrase 2	CA2	0.0239
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0238
1353	DNA topoisomerase 1	TOP1	0.0237
3552	DNA topoisomerase 1	topA	0.0237
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0236
295	Carbonic anhydrase 1	CA1	0.0234
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0233
2808	Chloramphenicol acetyltransferase 3	cat3	0.0233
465	Calmodulin	CALM1	0.0233
592	Carbonic anhydrase 4	CA4	0.0232
450	Muscarinic acetylcholine receptor M4	CHRM4	0.023
723	Cytosolic phospholipase A2	PLA2G4A	0.0227
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0226
1650	Heme carrier protein 1	SLC46A1	0.0226
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0226
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0225
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
638	D(3) dopamine receptor	DRD3	0.0221
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.022
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.022
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0218
365	Dihydrofolate reductase	DHFR	0.0217
2381	Dihydrofolate reductase	DFR1	0.0217
2833	Dihydrofolate reductase	Not Available	0.0217
2931	Dihydrofolate reductase	folA	0.0217
3544	Dihydrofolate reductase	folA	0.0217
3682	Dihydrofolate reductase	folA	0.0217
6642	Dihydrofolate reductase	folA	0.0217
6756	Dihydrofolate reductase	dfrA	0.0217
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0216
1867	Major prion protein	PRNP	0.0216
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0215
199	Monocarboxylate transporter 8	SLC16A2	0.0214
6033	High affinity interleukin-8 receptor A	CXCR1	0.0214
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.021
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0207
4773	Deoxycytidine kinase	DCK	0.0206
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0205
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0204
683	Potassium transporter	GK0582	0.0203
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0202
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0201
1757	Myeloperoxidase	MPO	0.0201
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.02
2016	Dipeptidase 1	DPEP1	0.0197
860	Nicotinamide N-methyltransferase	NNMT	0.0196
928	Nicotinic acid receptor 2	GPR109B	0.0196
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0196
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0196
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0196
699	Nicotinic acid receptor 1	GPR109A	0.0196
5626	Nucleoside diphosphate kinase B	NME2	0.0195
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0194
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0194
789	Alpha-1D adrenergic receptor	ADRA1D	0.0193
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0193
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0193
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0192
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0191
122	P2Y purinoceptor 12	P2RY12	0.019
232	Corticosteroid-binding globulin	SERPINA6	0.0189
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0189
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0189
1630	Integrin beta-2	ITGB2	0.0189
293	Gamma-glutamyl hydrolase	GGH	0.0187
6207	30S ribosomal protein S14	rpsN	0.0186
6209	30S ribosomal protein S19	rpsS	0.0186
6712	30S ribosomal protein S19	rpsS	0.0186
6726	30S ribosomal protein S19	rpsS	0.0186
3810	Catechol O-methyltransferase	COMT	0.0183
49	Endothelin B receptor	EDNRB	0.0182
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0181
3270	Elongation factor G	fusA	0.0181
183	Vascular endothelial growth factor A	VEGFA	0.0177
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0177
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0177
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0177
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0177
629	Alpha-2B adrenergic receptor	ADRA2B	0.0175
131	Synaptic vesicular amine transporter	SLC18A2	0.0174
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0173
578	Endothelin-1 receptor	EDNRA	0.0172
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0171
891	Dihydropteroate synthase	folP	0.0171
5359	Dihydropteroate synthase	folP	0.0171
7175	Dihydropteroate synthase	sulI	0.0171
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.017
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.017
3809	Estrogen-related receptor gamma	ESRRG	0.0169
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
5818	Folate receptor alpha	FOLR1	0.0168
130	Prostacyclin synthase	PTGIS	0.0168
5294	Nucleoside diphosphate kinase A	NME1	0.0167
2249	Aspartate aminotransferase	aspC	0.0167
2671	Aspartate aminotransferase	aspC	0.0167
5490	Aspartate aminotransferase	Not Available	0.0167
115	Penicillin-binding protein 2	mrdA	0.0166
6069	Penicillin-binding protein 2	mrdA	0.0166
6118	Penicillin-binding protein 2	penA	0.0166
6187	Penicillin-binding protein 2	pbpA	0.0166
6686	Penicillin-binding protein 2	pbp2	0.0166
6939	Penicillin-binding protein 2	mrdA	0.0166
7163	Penicillin-binding protein 2	pbpA	0.0166
165	FL cytokine receptor	FLT3	0.0164
3639	Thymidine phosphorylase	deoA	0.0164
3936	Thymidine phosphorylase	TYMP	0.0164
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0163
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0163
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0163
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0161
13	Aminomethyltransferase, mitochondrial	AMT	0.0161
2320	Thymidine kinase, cytosolic	TK1	0.016
469	Annexin A1	ANXA1	0.016
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.016
3939	Amine oxidase [flavin-containing] B	MAOB	0.016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.016
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3179	2-isopropylmalate synthase	leuA	0.0159
117	Sterol O-acyltransferase 1	SOAT1	0.0159
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0159
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0159
6500	Phospholipase A2	PLA2G1B	0.0157
284	DNA-directed RNA polymerase beta chain	rpoB	0.0156
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0156
378	Alpha-2C adrenergic receptor	ADRA2C	0.0156
53	Solute carrier family 12 member 5	SLC12A5	0.0156
663	Solute carrier family 12 member 4	SLC12A4	0.0156
4237	50S ribosomal protein L22	rplV	0.0156
1	Peptidoglycan synthetase ftsI	ftsI	0.0155
4155	Peptidoglycan synthetase ftsI	ftsI	0.0155
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0154
818	50S ribosomal protein L10	rplJ	0.0154
6837	Serine/threonine-protein kinase 17B	STK17B	0.0153
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0153
1178	Adenosine A2a receptor	ADORA2A	0.0153
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
6044	Serum paraoxonase/lactonase 3	PON3	0.0151
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0149
4238	50S ribosomal protein L4	rplD	0.0149
5578	50S ribosomal protein L4	rplD	0.0149
6173	50S ribosomal protein L4	rplD	0.0149
6219	50S ribosomal protein L4	rplD	0.0149
6126	Carbonic anhydrase 7	CA7	0.0149
777	Tumor necrosis factor	TNF	0.0148
6218	Pannexin-1	PANX1	0.0148
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0148
1192	Sulfotransferase 1A1	SULT1A1	0.0147
1629	Transcription factor AP-1	JUN	0.0146
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0146
3856	Fibroblast growth factor receptor 3	FGFR3	0.0146
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0146
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0146
310	Solute carrier family 12 member 2	SLC12A2	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
4217	Telomerase reverse transcriptase	TERT	0.0144
432	D(4) dopamine receptor	DRD4	0.0143
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0141
811	Translocator protein	TSPO	0.0141
1792	Tissue-type plasminogen activator	PLAT	0.0141
572	Integrin alpha-L	ITGAL	0.014
867	Penicillin-binding protein 3	pbpC	0.014
6119	Penicillin-binding protein 3	pbp3	0.014
7154	Penicillin-binding protein 3	pbp3	0.014
7157	Penicillin-binding protein 3	LMHCC_2184	0.014
7162	Penicillin-binding protein 3	pbpB	0.014
7172	Penicillin-binding protein 3	pbp3	0.014
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0139
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0139
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0139
1654	Interleukin-1 beta	IL1B	0.0137
474	Acetylcholinesterase	ACHE	0.0137
16	Adenosine A1 receptor	ADORA1	0.0137
908	Glutathione S-transferase theta-1	GSTT1	0.0136
6043	Putative G-protein coupled receptor 44	GPR44	0.0136
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0136
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0136
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0135
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0134
2599	Tyrosine-protein kinase HCK	HCK	0.0134
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0134
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0134
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0133
6014	Cytochrome P450 2A13	CYP2A13	0.0133
3014	Ribonuclease UK114	HRSP12	0.0132
5428	Replication protein	repA	0.0132
3617	Non-heme chloroperoxidase	cpo	0.0132
5426	Non-heme chloroperoxidase	cpo	0.0132
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0132
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0132
1010	Cytochrome P450 51A1	CYP51A1	0.0132
3018	HTH-type transcriptional regulator malT	malT	0.0132
65	Matrix metalloproteinase-9	Not Available	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0131
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.013
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.013
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
3685	Catabolite gene activator	crp	0.0127
4655	Adenylate cyclase	cyaC	0.0127
4759	Adenylate cyclase	cyaB2	0.0127
3334	Deacetoxycephalosporin C synthetase	cefE	0.0127
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0126
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0126
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0123
2021	Thrombomodulin	THBD	0.0123
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
5787	Angiopoietin-1 receptor	TEK	0.0121
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0118
6102	Arylamine N-acetyltransferase 2	NAT2	0.0118
4192	DNA topoisomerase 2-beta	TOP2B	0.0118
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0117
2391	Ferrochelatase	hemH	0.0116
6502	Ferrochelatase	DKFZp686P18130	0.0116
1591	Ferrochelatase, mitochondrial	FECH	0.0116
6146	High affinity copper uptake protein 1	SLC31A1	0.0116
5880	Thrombopoietin receptor	MPL	0.0114
2958	Probable tautomerase ydcE	pptA	0.0113
2573	Cocaine esterase	cocE	0.0113
7263	Cocaine esterase	Not Available	0.0113
2449	Tubulin alpha-3 chain	TUBA1A	0.0112
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
1507	Cytochrome c	CYCS	0.0112
3115	Ras-related protein Rab-9	RAB9A	0.0111
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0111
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0111
494	Caspase-1	CASP1	0.0111
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0111
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0111
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0111
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0111
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.011
716	5-hydroxytryptamine 7 receptor	HTR7	0.0109
4760	Mll3241 protein	mll3241	0.0109
823	Fibroblast growth factor receptor 2	FGFR2	0.0108
2443	Azurin	azu	0.0108
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0108
94	5-hydroxytryptamine 4 receptor	HTR4	0.0107
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0107
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0107
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0106
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0106
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0106
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0106
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0105
84	Nuclear receptor 0B1	NR0B1	0.0104
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0103
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0102
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0102
1198	Serum paraoxonase/arylesterase 1	PON1	0.0102
6223	Penicillin-binding protein 1C	pbpC	0.0102
1039	Histone deacetylase 9	HDAC9	0.0101
3932	Glutathione S-transferase A2	GSTA2	0.0101
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0101
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0101
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0101
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0101
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.01
3760	Penicillin-binding protein 5 precursor	dacA	0.01
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.01
6493	Cytochrome c oxidase subunit 6C	COX6C	0.01
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.01
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.01
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.01
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.01
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.01
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.01
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.01
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.01
6559	Cytochrome c oxidase subunit 2	ctaC	0.01
6669	Cytochrome c oxidase subunit 2	ctaC	0.01
371	Cytochrome c oxidase subunit 1	MT-CO1	0.01
6558	Cytochrome c oxidase subunit 1	ctaD	0.01
751	Potassium channel subfamily K member 6	KCNK6	0.01
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0099
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0099
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0098
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
6168	Solute carrier family 22 member 16	SLC22A16	0.0097
1405	Thiopurine S-methyltransferase	TPMT	0.0097
4203	Histamine N-methyltransferase	HNMT	0.0096
1656	CYP2B protein	CYP2B	0.0096
768	FK506-binding protein 1A	FKBP1A	0.0096
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0096
6163	Copper-transporting ATPase 2	ATP7B	0.0095
6165	Copper-transporting ATPase 1	ATP7A	0.0095
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0095
1760	Aminopeptidase N	ANPEP	0.0095
6843	Aminopeptidase N	pepN	0.0095
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0094
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6042	Prostaglandin reductase 2	PTGR2	0.0093
2077	Caspase-3	CASP3	0.0093
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0093
992	Protein tyrosine kinase 2 beta	PTK2B	0.0092
2540	Choloylglycine hydrolase	cbh	0.0092
172	Potassium channel subfamily K member 1	KCNK1	0.0092
163	D(1B) dopamine receptor	DRD5	0.0091
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0091
6211	Tubulin epsilon chain	TUBE1	0.0091
6210	Tubulin delta chain	TUBD1	0.0091
6212	Tubulin gamma-1 chain	TUBG1	0.0091
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0091
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0091
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0091
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0091
896	Glutathione S-transferase Mu 1	GSTM1	0.009
239	Coagulation factor X	F10	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
7	Nitric oxide synthase, inducible	NOS2	0.009
819	Penicillin-binding protein 4	dacB	0.009
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0089
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0089
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0088
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0088
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0088
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0088
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0088
427	Substance-P receptor	TACR1	0.0088
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0087
5300	Antigen peptide transporter 1	TAP1	0.0087
2216	Fibroblast growth factor receptor 4	FGFR4	0.0087
705	Glutamate receptor 1	GRIA1	0.0087
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0087
6501	Fatty acid-binding protein, liver	FABP1	0.0086
2693	Heat-labile enterotoxin B chain	eltB	0.0086
461	Glycine receptor subunit alpha-3	GLRA3	0.0086
6824	Tyrosine-protein kinase Lyn	LYN	0.0084
6645	D-amino-acid oxidase	DAO	0.0084
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0084
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0083
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0083
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0082
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0082
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0082
1517	Beta-3 adrenergic receptor	ADRB3	0.0082
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0081
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0081
68	Cannabinoid receptor 1	CNR1	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.008
208	DNA-directed RNA polymerase beta' chain	rpoC	0.008
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.008
2636	Shikimate dehydrogenase	aroE	0.0079
3515	Shikimate dehydrogenase	aroE	0.0079
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0079
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0077
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0077
1618	High affinity nerve growth factor receptor	NTRK1	0.0077
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0077
1313	Lactoylglutathione lyase	GLO1	0.0077
517	Alcohol dehydrogenase 1C	ADH1C	0.0076
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0076
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
1541	Metalloproteinase	mmp20	0.0074
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0074
551	Carnitine O-acetyltransferase	CRAT	0.0073
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0073
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0073
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0073
611	Retinal dehydrogenase 1	ALDH1A1	0.0072
1050	Bile salt sulfotransferase	SULT2A1	0.0072
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0072
54	Prothrombin	F2	0.0071
6131	Carbonic anhydrase 14	CA14	0.0071
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
88	Retinoic acid receptor RXR-beta	RXRB	0.007
814	Ryanodine receptor 1	RYR1	0.007
634	Squalene monooxygenase	SQLE	0.007
7196	Squalene monooxygenase	ERG1	0.007
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.007
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0069
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0068
1196	Complement decay-accelerating factor	CD55	0.0068
3086	Plasmepsin-2	Not Available	0.0068
5934	Cytochrome P450 26A1	CYP26A1	0.0068
976	Platelet glycoprotein IX	GP9	0.0067
921	Glutamate receptor 2	GRIA2	0.0067
267	Plasminogen activator inhibitor 1	SERPINE1	0.0067
702	UMP-CMP kinase	CMPK1	0.0067
6138	Multidrug resistance protein 3	ABCB4	0.0067
4226	Uridine phosphorylase 2	UPP2	0.0066
6122	Carbonic anhydrase 3	CA3	0.0066
5669	50S ribosomal protein L27	rpmA	0.0066
5675	Chaperone protein torD	torD	0.0065
5670	Organic hydroperoxide resistance protein	ohr	0.0065
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0065
5410	Unsaturated glucuronyl hydrolase	ugl	0.0065
5676	Axin-1	AXIN1	0.0065
5673	C protein alpha-antigen	bca	0.0065
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0065
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0065
1275	Estrogen sulfotransferase	SULT1E1	0.0064
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0064
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0064
563	Thyroid peroxidase	TPO	0.0064
319	Opioid receptor, sigma 1	OPRS1	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
1525	Heparin-binding growth factor 2	FGF2	0.0062
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0061
6221	Steroid hormone receptor ERR1	ESRRA	0.0061
1291	cAMP response element-binding protein	CREB1	0.0061
4225	Uridine phosphorylase 1	UPP1	0.0061
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0059
2232	Interleukin-5	IL5	0.0059
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0059
1593	Mucin-2	MUC2	0.0059
4210	Toll-like receptor 4	TLR4	0.0059
2285	Streptogramin A acetyltransferase	vatD	0.0059
936	Ephrin type-A receptor 2	EPHA2	0.0059
397	Monocarboxylate transporter 3	SLC16A8	0.0059
195	Monocarboxylate transporter 7	SLC16A6	0.0058
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0058
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0058
218	Monocarboxylate transporter 5	SLC16A4	0.0058
909	Maleylacetoacetate isomerase	GSTZ1	0.0058
429	Monocarboxylate transporter 6	SLC16A5	0.0058
1123	Eosinophil cationic protein	RNASE3	0.0058
6174	50S ribosomal protein L32	rpmF	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0057
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0057
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0057
413	Amidophosphoribosyltransferase	PPAT	0.0057
2515	Amidophosphoribosyltransferase	purF	0.0057
3714	Amidophosphoribosyltransferase	purF	0.0057
3191	Histidinol dehydrogenase	hisD	0.0057
3007	Carbonic anhydrase 12	CA12	0.0057
4205	Carbonic anhydrase 9	CA9	0.0057
484	Tyrosine-protein kinase ABL2	ABL2	0.0057
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0056
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0056
459	Retinoic acid receptor RXR-alpha	RXRA	0.0056
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0055
153	Dopamine beta-hydroxylase	DBH	0.0055
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0055
6506	Stathmin-4	STMN4	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
571	Melatonin receptor type 1A	MTNR1A	0.0055
362	Melatonin receptor type 1B	MTNR1B	0.0055
106	Cannabinoid receptor 2	CNR2	0.0054
2417	Chloramphenicol acetyltransferase	cat	0.0054
3278	Chloramphenicol acetyltransferase	cat	0.0054
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0054
780	Retinoic acid receptor RXR-gamma	RXRG	0.0054
2810	Dr hemagglutinin structural subunit	draA	0.0054
856	Vitamin D3 receptor	VDR	0.0054
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0053
1714	Mitogen-activated protein kinase 3	MAPK3	0.0053
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0053
174	Sigma 1-type opioid receptor	SIGMAR1	0.0053
4311	tRNA	TRDMT1	0.0053
4325	tRNA	trmD	0.0053
4328	tRNA	trmD	0.0053
4811	Amylosucrase	ams	0.0053
2280	Listeriolysin regulatory protein	prfA	0.0052
408	Riboflavin kinase	RFK	0.0052
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0052
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0052
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0052
191	Peptide methionine sulfoxide reductase	MSRA	0.0052
52	Pyruvate kinase isozymes R/L	PKLR	0.0052
654	Flavin reductase	BLVRB	0.0052
268	Adenosine A2b receptor	ADORA2B	0.0052
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
4103	Proteasome subunit beta type 2	PSMB2	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.005
6171	Solute carrier family 28 member 3	SLC28A3	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
771	Pyruvate carboxylase, mitochondrial	PC	0.0049
173	Toll-like receptor 7	TLR7	0.0049
76	Nitric-oxide synthase, brain	NOS1	0.0048
760	Fibroblast growth factor 1	FGF1	0.0048
340	Apoptotic protease-activating factor 1	APAF1	0.0048
707	72 kDa type IV collagenase	MMP2	0.0047
718	Folate receptor gamma	FOLR3	0.0047
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0047
299	Folate receptor beta	FOLR2	0.0047
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0047
2159	Quinone oxidoreductase	CRYZ	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1648	Elastin	ELN	0.0046
162	Retinoic acid receptor gamma-1	RARG	0.0045
1483	Membrane copper amine oxidase	AOC3	0.0045
518	Peroxidase/catalase T	katG	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0044
482	Glycine receptor subunit alpha-1	GLRA1	0.0044
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0044
3957	Adenosine deaminase	ADA	0.0043
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0043
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
3729	Citrate synthase	gltA	0.0042
4575	Citrate synthase	cit	0.0042
4580	Citrate synthase	gltA	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0041
581	Cytochrome P450 2R1	CYP2R1	0.0041
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0041
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2314	Triosephosphate isomerase	TPI	0.004
3417	Triosephosphate isomerase	tpiA	0.004
3443	Triosephosphate isomerase	tpiA	0.004
6346	Triosephosphate isomerase	TPI1	0.004
2371	Pantothenate kinase	coaA	0.0039
291	Nitric-oxide synthase, endothelial	NOS3	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
5482	Sialidase-2	NEU2	0.0039
2408	Tyrosine-protein kinase SYK	SYK	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
1864	RET proto-oncogene	RET	0.0038
6048	Troponin C, skeletal muscle	TNNC2	0.0038
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0038
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0038
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0038
2300	Lysozyme	E	0.0037
3633	Lysozyme	R	0.0037
5597	Lysozyme	17	0.0037
822	Aldose reductase	AKR1B1	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
3601	Dihydropteroate synthase 1	folP1	0.0037
3807	Dihydropteroate synthase 1	folP1	0.0037
3808	Dihydropteroate synthase 2	folP2	0.0037
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
4564	YvbK protein	yvbK	0.0036
4567	Putative acyl-CoA thioester hydrolase HI0827	HI_0827	0.0036
4566	Acyl-CoA hydrolase	BC_2038	0.0036
4572	Acyl-CoA hydrolase	BH0798	0.0036
4576	Aac(6')-Ii protein	aac(6')-Ii	0.0036
4577	4'-phosphopantetheinyl transferase sfp	sfp	0.0036
2528	Fatty acid metabolism regulator protein	fadR	0.0036
6740	Fatty acid metabolism regulator protein	fadR	0.0036
4579	Serine acetyltransferase	cysE	0.0036
6807	Serine acetyltransferase	cysE	0.0036
997	Protein kinase C beta type	PRKCB	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
164	Histamine H4 receptor	HRH4	0.0035
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
5798	Mitogen-activated protein kinase 11	MAPK11	0.0035
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
444	Alcohol dehydrogenase 1B	ADH1B	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
6432	Transporter	snf	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
5328	Prostaglandin F synthase	Tb11.02.2310	0.0033
735	Alanine aminotransferase 1	GPT	0.0032
3904	Alanine aminotransferase 2	GPT2	0.0032
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0032
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
3489	Acetyl-coenzyme A synthetase	acs	0.0031
2396	Formyl-coenzyme A transferase	frc	0.0031
3457	Formyl-coenzyme A transferase	frc	0.0031
4574	PROBABLE NAPHTHOATE SYNTHASE MENB	menB	0.0031
3024	Crotonobetainyl-CoA:carnitine CoA-transferase	caiB	0.0031
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0031
4563	Acetyl transferase	rimL	0.0031
4565	Aminoglycoside 6'-N-acetyltransferase	aac(6')-Iy	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0031
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
569	Retinal dehydrogenase 2	ALDH1A2	0.003
5682	Ribonuclease pancreatic	RNASE1	0.003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
3830	Calreticulin	CALR	0.0029
1992	Vitamin D-binding protein	GC	0.0029
2236	Casein kinase II subunit alpha	CSNK2A1	0.0029
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0029
292	Activin receptor type-1	ACVR1	0.0029
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0029
4573	Histone acetyltransferase PCAF	KAT2B	0.0029
2377	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Not Available	0.0029
2560	Galactoside O-acetyltransferase	lacA	0.0029
3199	Phosphopantetheine adenylyltransferase	coaD	0.0029
3543	Phosphopantetheine adenylyltransferase	coaD	0.0029
3567	Phosphopantetheine adenylyltransferase	coaD	0.0029
5289	Phosphopantetheine adenylyltransferase	coaD	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
849	Activated CDC42 kinase 1	TNK2	0.0028
2248	Malate synthase G	glcB	0.0028
3190	Malate synthase G	glcB	0.0028
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0028
3178	Formate acetyltransferase 1	pflB	0.0028
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0028
666	NADP-dependent malic enzyme	ME1	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0028
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
5126	Arginase	rocF	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3913	Glutamic acid decarboxylase	GAD65	0.0027
4404	FcbC1 protein	fcbC	0.0027
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0027
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0027
6034	Hydroxyindole O-methyltransferase	ASMT	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
6035	Nuclear receptor ROR-beta	RORB	0.0027
6036	Eosinophil peroxidase	EPX	0.0027
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0026
719	Retinoic acid receptor responder protein 1	RARRES1	0.0026
770	Retinoic acid-induced protein 3	GPRC5A	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
473	L-lactate dehydrogenase A chain	LDHA	0.0026
2376	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0026
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0026
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0026
5322	Oxidoreductase ydhF	ydhF	0.0025
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0025
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0025
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0025
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0025
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0025
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0025
5332	MtdA bifunctional protein	mtdA	0.0025
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
4403	Protein iolS	iolS	0.0025
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0025
5330	General stress protein 69	yhdN	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0024
615	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
3138	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
4568	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
6370	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.0024
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
2596	Acetyl-CoA acetyltransferase	phbA	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
6228	Nuclear receptor coactivator 1	NCOA1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
765	Indoleamine 2,3-dioxygenase	IDO1	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0022
5073	Ferredoxin--NADP reductase	petH	0.0022
5076	Ferredoxin--NADP reductase	fpr	0.0022
5119	Ferredoxin--NADP reductase	petH	0.0022
5121	Ferredoxin--NADP reductase	fpr	0.0022
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0022
3446	NADP-dependent alcohol dehydrogenase	adh	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
2286	Isocitrate dehydrogenase [NADP]	icd	0.0022
2302	Isocitrate dehydrogenase [NADP]	icd	0.0022
2771	Isocitrate dehydrogenase [NADP]	icd	0.0022
4582	Putative pteridine reductase 2	ptr2	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0022
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0022
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0022
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
989	L-xylulose reductase	DCXR	0.0022
3404	Exotoxin A	eta	0.0022
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0022
298	Renin	REN	0.0021
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
2207	Rhodopsin	RHO	0.0021
3937	Fatty-acid amide hydrolase	FAAH	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
6297	Prostaglandin reductase 1	PTGR1	0.002
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.002
4531	Putative ketoacyl reductase	actIII	0.002
3062	Aspartate-semialdehyde dehydrogenase	asd	0.002
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.002
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
2675	Pteridine reductase 1	PTR1	0.0019
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0019
2697	Uridine-cytidine kinase 2	UCK2	0.0019
1124	Sepiapterin reductase	SPR	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
857	Malate dehydrogenase, mitochondrial	MDH2	0.0018
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
5288	Shikimate kinase	aroK	0.0017
5287	Signaling protein	Not Available	0.0017
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0017
5293	Shikimate kinase 2	aroL	0.0017
5304	UPF0166 protein TM_0021	TM_0021	0.0017
4346	Polynucleotide kinase	pseT	0.0017
5292	Putative partitioning protein	TT_C1605	0.0017
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0017
5266	Activator of	hgdC	0.0017
5259	Transcriptional regulator	ntrC1	0.0017
6699	Transcriptional regulator	Cgl2612	0.0017
2874	Nitrogenase iron protein 1	nifH1	0.0017
5283	D-alanine--D-alanine ligase B	ddlB	0.0017
5281	Plasmid segregation protein parM	parM	0.0017
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0017
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0017
5299	D-alanine--D-alanine ligase	ddl	0.0017
6598	D-alanine--D-alanine ligase	ddl	0.0017
5315	Chaperone protein htpG	htpG	0.0017
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0017
5291	Glycogen synthase 1	glgA1	0.0017
5264	DNA replication protein	REP	0.0017
5277	Preprotein translocase subunit secA	secA	0.0017
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0017
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0017
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0017
5284	Large T antigen	Not Available	0.0017
5308	Preprotein translocase secA 1 subunit	secA1	0.0017
5285	Kinesin heavy chain	KIF5B	0.0017
2091	Endoplasmin	HSP90B1	0.0017
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0016
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0016
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0016
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0016
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0016
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0016
251	Alcohol dehydrogenase 1A	ADH1A	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
4041	Microsomal glutathione S-transferase 2	MGST2	0.0016
4992	Cytochrome c peroxidase	Not Available	0.0016
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
207	Glutathione synthetase	GSS	0.0015
5269	Glutathione synthetase	gshB	0.0015
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4106	Guanylate kinase	GUK1	0.0013
4516	Guanylate kinase	gmk	0.0013
4837	Cag-alfa	cag-alfa	0.0013
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0013
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0013
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0013
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0013
5646	Galactokinase	GALK1	0.0013
1912	Excitatory amino acid transporter 1	SLC1A3	0.0013
4838	PMS1 protein homolog 2	PMS2	0.0013
4019	Excitatory amino acid transporter 4	SLC1A6	0.0013
4839	DNA polymerase III subunit tau	dnaX	0.0013
922	Glutamate receptor 4	GRIA4	0.0013
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0013
5302	TrwB	trwB	0.0013
4026	Aspartyl aminopeptidase	DNPEP	0.0013
5265	FtsH	ftsH	0.0013
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0013
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0013
4016	Excitatory amino acid transporter 5	SLC1A7	0.0013
1047	Excitatory amino acid transporter 2	SLC1A2	0.0013
927	Metabotropic glutamate receptor 8	GRM8	0.0013
664	Glutamate decarboxylase 2	GAD2	0.0013
3890	Glutamate decarboxylase 2	GAD2	0.0013
4020	Glutamyl aminopeptidase	ENPEP	0.0013
4018	Glutamate receptor delta-2 subunit	GRID2	0.0013
5189	Trimethylamine dehydrogenase	tmd	0.0013
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0013
925	Metabotropic glutamate receptor 4	GRM4	0.0013
926	Metabotropic glutamate receptor 7	GRM7	0.0013
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0013
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0013
4027	Glutamate receptor delta-1 subunit	GRID1	0.0013
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0013
4017	5-oxoprolinase	OPLAH	0.0013
4774	NTPase P4	Not Available	0.0013
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0013
2270	Dephospho-CoA kinase	coaE	0.0013
2284	Adenylate kinase	adk	0.0013
2296	Adenylate kinase	adk	0.0013
2311	Adenylate kinase	adk	0.0013
2312	Adenylate kinase	Not Available	0.0013
3470	Hypothetical protein MG245 homolog	MPN_348	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
3175	Glutamate--cysteine ligase	gshA	0.0013
3426	Glutamine synthetase	glnA	0.0013
3987	Glutamine synthetase	GLUL	0.0013
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0013
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0013
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
2683	Mono-ADP-ribosyltransferase C3	C3	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
625	Glutamate carboxypeptidase 2	FOLH1	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
3221	Cytochrome c4	cc4	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
2390	Nonsecretory ribonuclease	RNASE2	0.0012
5312	Kinesin-like protein KIF1A	KIF1A	0.0012
2922	Glycerol kinase	glpK	0.0012
5271	Focal adhesion kinase 1	PTK2	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6859	Protein S100-A4	S100A4	0.0012
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0012
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0011
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0011
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0011
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0011
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0011
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0011
2282	Protein recA	recA	0.0011
2315	Protein recA	recA	0.0011
2332	Protein recA	recA	0.0011
5263	Protein recA	recA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
916	Metabotropic glutamate receptor 1	GRM1	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
665	Phosphoserine aminotransferase	PSAT1	0.0011
4652	Phosphoserine aminotransferase	serC	0.0011
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0011
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0011
420	Glutamate decarboxylase 1	GAD1	0.0011
3900	Glutamate decarboxylase 1	GAD1	0.0011
2615	Chemotaxis protein cheA	cheA	0.0011
1881	Hexokinase-1	HK1	0.0011
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
2892	Acetylglutamate kinase	argB	0.0011
3550	Acetylglutamate kinase	argB	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
3669	Ribokinase	rbsK	0.0011
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
923	Glutamate receptor 3	GRIA3	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
5006	RNASE4 protein	RNASE4	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
1671	Excitatory amino acid transporter 3	SLC1A1	0.001
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.001
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.001
714	Glutathione reductase, mitochondrial	GSR	0.001
788	Creatine kinase M-type	CKM	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2727	S-adenosylmethionine synthetase	metK	0.001
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.001
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.001
3877	Growth-inhibiting protein 18	GIG18	0.001
426	Aspartate aminotransferase, mitochondrial	GOT2	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2334	Dethiobiotin synthetase	bioD	0.001
6555	Dethiobiotin synthetase	bioD	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2603	Beta-lactamase II	blm	0.001
763	Tyrosine aminotransferase	TAT	0.001
5493	Tyrosine aminotransferase	Not Available	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.001
3583	6-phosphogluconolactonase	pgl	0.001
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
48	Pyridoxal kinase	PDXK	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0009
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6395	Myosin-14	MYH14	0.0009
2251	Thymidylate kinase	tmk	0.0009
2254	Thymidylate kinase	DTYMK	0.0009
3522	Thymidylate kinase	tmk	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
816	Biliverdin reductase A	BLVRA	0.0009
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0009
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
1422	Serine/threonine-protein kinase 6	AURKA	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
2132	Protein S100-B	S100B	0.0009
3379	Kinesin-like protein KIF11	KIF11	0.0008
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0008
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0008
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0008
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0008
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0008
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0008
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0008
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0008
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0008
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0008
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0008
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0008
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0008
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0008
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0008
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0008
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0008
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0008
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0008
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0008
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0008
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0008
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0008
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0008
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0008
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0008
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0008
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0008
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0008
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0008
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0008
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0008
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0008
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0008
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0008
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0008
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0008
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0008
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0008
107	C-4 methylsterol oxidase	SC4MOL	0.0008
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0008
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0008
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0008
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0008
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0008
729	GDP-L-fucose synthetase	TSTA3	0.0008
3463	GDP-L-fucose synthetase	fcl	0.0008
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0008
167	L-lactate dehydrogenase C chain	LDHC	0.0008
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0008
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0008
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0008
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0008
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0008
206	3-keto-steroid reductase	HSD17B7	0.0008
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0008
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0008
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0008
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0008
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0008
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0008
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0008
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0008
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0008
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0008
34	7-dehydrocholesterol reductase	DHCR7	0.0008
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0008
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0008
711	UDP-glucose 6-dehydrogenase	UGDH	0.0008
3672	UDP-glucose 6-dehydrogenase	hasB	0.0008
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0008
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0008
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0008
643	Peroxisomal bifunctional enzyme	EHHADH	0.0008
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0008
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0008
810	Heme oxygenase 1	HMOX1	0.0008
3391	Heme oxygenase 1	pbsA1	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
3822	Actin, alpha skeletal muscle	ACTA1	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0008
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0008
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0008
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0008
396	Alcohol dehydrogenase 4	ADH4	0.0008
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0008
328	Sorbitol dehydrogenase	SORD	0.0008
597	Dihydropteridine reductase	QDPR	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0008
12	Alcohol dehydrogenase class 3	ADH5	0.0008
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0008
77	L-lactate dehydrogenase B chain	LDHB	0.0008
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0007
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0007
6026	Alcohol dehydrogenase 6	ADH6	0.0007
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0007
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0007
626	Cysteine dioxygenase type 1	CDO1	0.0007
627	11-cis retinol dehydrogenase	RDH5	0.0007
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0007
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
125	DNA polymerase beta	POLB	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
279	Tyrosinase	TYR	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
4920	Peroxidase/catalase	katG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00175 - Pravastatin

Targets

Enzymes

Transporters

Predictions